HEATR9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)6.55283259
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.67802236
3actin nucleation (GO:0045010)5.56216893
4regulation of activation of Janus kinase activity (GO:0010533)5.54767102
5NIK/NF-kappaB signaling (GO:0038061)5.32705359
6regulation of chronic inflammatory response (GO:0002676)5.22057313
7cytidine metabolic process (GO:0046087)5.04165510
8cytidine catabolic process (GO:0006216)5.04165510
9cytidine deamination (GO:0009972)5.04165510
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96204363
11sperm motility (GO:0030317)4.96076357
12natural killer cell mediated cytotoxicity (GO:0042267)4.89316686
13natural killer cell mediated immunity (GO:0002228)4.89316686
14T cell migration (GO:0072678)4.79544127
15positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.73478792
16DNA deamination (GO:0045006)4.57925262
17negative regulation of T cell apoptotic process (GO:0070233)4.55208559
18regulation of B cell receptor signaling pathway (GO:0050855)4.55098073
19positive regulation of natural killer cell differentiation (GO:0032825)4.53203887
20cell wall macromolecule catabolic process (GO:0016998)4.52695184
21cell wall macromolecule metabolic process (GO:0044036)4.52695184
22negative regulation of cell killing (GO:0031342)4.52397351
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52397351
24sexual reproduction (GO:0019953)4.46202231
25neutrophil activation involved in immune response (GO:0002283)4.45190594
26pyrimidine ribonucleoside catabolic process (GO:0046133)4.42679740
27regulation of leukocyte mediated cytotoxicity (GO:0001910)4.39978514
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.35784558
29cellular response to type I interferon (GO:0071357)4.33644870
30type I interferon signaling pathway (GO:0060337)4.33644870
31antigen processing and presentation of endogenous antigen (GO:0019883)4.30215992
32response to type I interferon (GO:0034340)4.29452744
33fusion of sperm to egg plasma membrane (GO:0007342)4.29179561
34regulation of T-helper 1 cell differentiation (GO:0045625)4.24393027
35negative thymic T cell selection (GO:0045060)4.24208004
36T-helper 1 type immune response (GO:0042088)4.23805829
37neutrophil activation (GO:0042119)4.22574525
38granulocyte activation (GO:0036230)4.20780973
39positive regulation of cell killing (GO:0031343)4.20133458
40regulation of alpha-beta T cell proliferation (GO:0046640)4.18045143
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17993444
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17993444
43positive regulation of B cell differentiation (GO:0045579)4.15845906
44negative T cell selection (GO:0043383)4.14884847
45regulation of regulatory T cell differentiation (GO:0045589)4.14462464
46reproduction (GO:0000003)4.11353540
47cellular response to interleukin-15 (GO:0071350)4.10127443
48regulation of hypersensitivity (GO:0002883)4.06914156
49multicellular organism reproduction (GO:0032504)4.01396771
50positive regulation of interleukin-17 production (GO:0032740)4.01152209
51regulation of dendritic cell antigen processing and presentation (GO:0002604)4.00256351
52regulation of memory T cell differentiation (GO:0043380)3.97453373
53regulation of cell killing (GO:0031341)3.95604551
54lymphocyte migration (GO:0072676)3.93019305
55positive regulation of gamma-delta T cell activation (GO:0046645)3.89944567
56positive regulation of T-helper cell differentiation (GO:0045624)3.84625320
57regulation of T cell tolerance induction (GO:0002664)3.84617734
58natural killer cell activation (GO:0030101)3.84000924
59regulation of RIG-I signaling pathway (GO:0039535)3.81002034
60T-helper cell differentiation (GO:0042093)3.78098931
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.78098931
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.77540016
63positive regulation of T cell cytokine production (GO:0002726)3.77407998
64negative regulation by host of viral transcription (GO:0043922)3.77364117
65cytolysis (GO:0019835)3.76279215
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74866375
67eosinophil chemotaxis (GO:0048245)3.74396707
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73052056
69dendritic cell chemotaxis (GO:0002407)3.71663546
70positive regulation of type 2 immune response (GO:0002830)3.70065348
71positive regulation of interleukin-12 production (GO:0032735)3.69634861
72positive regulation of immune response to tumor cell (GO:0002839)3.66784850
73regulation of immune response to tumor cell (GO:0002837)3.66784850
74regulation of response to tumor cell (GO:0002834)3.66784850
75positive regulation of response to tumor cell (GO:0002836)3.66784850
76megakaryocyte development (GO:0035855)3.66528613
77positive regulation of interferon-alpha production (GO:0032727)3.65782604
78positive regulation of antigen processing and presentation (GO:0002579)3.64536889
79T cell costimulation (GO:0031295)3.64167738
80defense response to protozoan (GO:0042832)3.61458500
81antigen processing and presentation via MHC class Ib (GO:0002475)3.60609499
82response to interleukin-15 (GO:0070672)3.60576603
83T cell differentiation involved in immune response (GO:0002292)3.59987818
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.59987818
85alpha-beta T cell activation involved in immune response (GO:0002287)3.59987818
86lymphocyte costimulation (GO:0031294)3.58892610
87positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.58148345
88positive regulation of humoral immune response (GO:0002922)3.57846238
89immunoglobulin mediated immune response (GO:0016064)3.57729407
90regulation of interleukin-2 biosynthetic process (GO:0045076)3.54208324
91acrosome reaction (GO:0007340)3.53467365
92positive regulation of tolerance induction (GO:0002645)3.53335750
93positive regulation of interleukin-8 secretion (GO:2000484)3.52387916
94leukocyte mediated cytotoxicity (GO:0001909)3.50468962
95myeloid dendritic cell differentiation (GO:0043011)3.49802002
96sequestering of actin monomers (GO:0042989)3.46999913
97acrosome assembly (GO:0001675)3.46097159
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.44796187
99lymphocyte chemotaxis (GO:0048247)3.43417907
100regulation of interferon-alpha production (GO:0032647)3.42266487
101negative regulation of viral genome replication (GO:0045071)3.41768788
102sperm-egg recognition (GO:0035036)3.39006491
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.37153855
104negative regulation of interleukin-17 production (GO:0032700)3.36191002
105interferon-gamma-mediated signaling pathway (GO:0060333)3.35515109
106regulation of B cell differentiation (GO:0045577)3.35451113
107eosinophil migration (GO:0072677)3.34785626
108T cell activation involved in immune response (GO:0002286)3.34710132
109regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.33094010
110regulation of natural killer cell mediated immunity (GO:0002715)3.32615732
111regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.32615732
112myeloid dendritic cell activation (GO:0001773)3.31313420
113regulation of interleukin-12 biosynthetic process (GO:0045075)3.30903147
114regulation of mononuclear cell migration (GO:0071675)3.28688768
115positive regulation of natural killer cell mediated immunity (GO:0002717)3.27880980
116positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.27880980
117negative regulation of stress fiber assembly (GO:0051497)3.27481698
118regulation of T-helper cell differentiation (GO:0045622)3.27395539
119regulation of interleukin-17 production (GO:0032660)3.26960159
120cellular response to interferon-beta (GO:0035458)3.26661796
121positive regulation of lymphocyte mediated immunity (GO:0002708)3.26591768
122regulation of tolerance induction (GO:0002643)3.24676764
123positive regulation of defense response to virus by host (GO:0002230)3.24672998
124response to protozoan (GO:0001562)3.24444644
125natural killer cell activation involved in immune response (GO:0002323)3.23842055
126positive thymic T cell selection (GO:0045059)3.23644324
127positive regulation of interleukin-2 production (GO:0032743)3.23634965
128cell-cell recognition (GO:0009988)3.23501082
129thrombin receptor signaling pathway (GO:0070493)3.23293912
130regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23041446
131positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22548264
132dendritic cell migration (GO:0036336)3.22259892
133regulation of necroptotic process (GO:0060544)3.21282104
134thymic T cell selection (GO:0045061)3.20395369
135regulation of T-helper 2 cell differentiation (GO:0045628)3.18678690
136regulation of gamma-delta T cell differentiation (GO:0045586)3.18604811
137regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.15670369
138regulation of antigen processing and presentation (GO:0002577)3.15215036
139regulation of gamma-delta T cell activation (GO:0046643)3.14969768
140positive regulation of monocyte chemotaxis (GO:0090026)3.11666416
141regulation of T cell cytokine production (GO:0002724)3.11654019
142positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.11508279
143B cell mediated immunity (GO:0019724)3.11113494
144response to interferon-alpha (GO:0035455)3.10806620
145T cell receptor signaling pathway (GO:0050852)3.10290195
146alpha-beta T cell activation (GO:0046631)3.10101162
147interferon-gamma production (GO:0032609)3.07505886
148positive regulation of calcium-mediated signaling (GO:0050850)3.07334238
149positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.07039017
150regulation of T-helper 1 type immune response (GO:0002825)3.06771709
151macrophage chemotaxis (GO:0048246)3.04218786
152antigen receptor-mediated signaling pathway (GO:0050851)3.02200205
153positive T cell selection (GO:0043368)3.01331209
154pyrimidine nucleoside catabolic process (GO:0046135)3.00146391
155regulation of T cell mediated cytotoxicity (GO:0001914)2.98329734
156regulation of lymphocyte chemotaxis (GO:1901623)2.96963646
157mast cell activation (GO:0045576)2.96577337
158regulation of platelet aggregation (GO:0090330)2.95689641
159positive regulation of interleukin-1 beta secretion (GO:0050718)2.95185395
160positive regulation of leukocyte mediated immunity (GO:0002705)2.93994476
161mitochondrial calcium ion transport (GO:0006851)2.93876694
162T cell selection (GO:0045058)2.92745407
163regulation of interleukin-8 secretion (GO:2000482)2.92464220
164leukocyte degranulation (GO:0043299)2.86757249
165regulation of T cell apoptotic process (GO:0070232)2.86369301
166B cell receptor signaling pathway (GO:0050853)2.85436483
167regulation of homotypic cell-cell adhesion (GO:0034110)2.85330391
168negative regulation of lymphocyte apoptotic process (GO:0070229)2.85020590
169regulation of lymphocyte mediated immunity (GO:0002706)2.83396315
170activated T cell proliferation (GO:0050798)2.81547488
171protein neddylation (GO:0045116)2.79244721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.14575898
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.07476522
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.73672816
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.11422703
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.08534930
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.71419419
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64749521
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.51122095
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40397054
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.18157483
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66468446
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65326494
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62738195
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48793984
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43736576
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.35810086
17EZH2_22144423_ChIP-Seq_EOC_Human2.21252377
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20634163
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20553355
20MYB_26560356_Chip-Seq_TH2_Human2.14044812
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.09742279
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06655443
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04659141
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04087799
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87625800
26RUNX_20019798_ChIP-Seq_JUKART_Human1.84122352
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81596931
28MYB_26560356_Chip-Seq_TH1_Human1.71706631
29MAF_26560356_Chip-Seq_TH1_Human1.71570474
30VDR_24787735_ChIP-Seq_THP-1_Human1.66537376
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66102440
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60902549
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.54482314
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.54443805
35GATA3_27048872_Chip-Seq_THYMUS_Human1.53402342
36HTT_18923047_ChIP-ChIP_STHdh_Human1.51729713
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45062595
38PU_27001747_Chip-Seq_BMDM_Mouse1.42401979
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41922567
40SPI1_23547873_ChIP-Seq_NB4_Human1.40407341
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36795042
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35962481
43GATA3_26560356_Chip-Seq_TH2_Human1.35003026
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.34333600
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32982087
46VDR_22108803_ChIP-Seq_LS180_Human1.27591750
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23966876
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23334875
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23023775
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.21865420
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21511505
52BCL6_27268052_Chip-Seq_Bcells_Human1.20237627
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17207444
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16102114
55BCOR_27268052_Chip-Seq_Bcells_Human1.15948965
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15841430
57GATA1_19941826_ChIP-Seq_K562_Human1.15526086
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14037938
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13256845
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13161656
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12439295
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11177462
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07751710
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.06791427
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06641257
66RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06528441
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05473381
68SMRT_27268052_Chip-Seq_Bcells_Human1.04646480
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04323549
70P68_20966046_ChIP-Seq_HELA_Human1.03920801
71VDR_24763502_ChIP-Seq_THP-1_Human1.03688339
72UTX_26944678_Chip-Seq_JUKART_Human1.02799780
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01635193
74SPI1_23127762_ChIP-Seq_K562_Human1.01557278
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00214347
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98746958
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97701944
78CIITA_25753668_ChIP-Seq_RAJI_Human0.97204398
79MAF_26560356_Chip-Seq_TH2_Human0.96172283
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96141309
81VDR_21846776_ChIP-Seq_THP-1_Human0.95472501
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95267921
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95232465
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93386837
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92623634
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92480875
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92237880
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92117692
89E2F1_20622854_ChIP-Seq_HELA_Human0.90416642
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.89951550
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88889203
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.88427683
93EGR1_19032775_ChIP-ChIP_M12_Human0.88054943
94TAF15_26573619_Chip-Seq_HEK293_Human0.88008510
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87680664
96GATA3_26560356_Chip-Seq_TH1_Human0.87134481
97P300_27268052_Chip-Seq_Bcells_Human0.86968787
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86401412
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85561337
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84446071
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83810998
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83809883
103CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83063637
104TCF7_22412390_ChIP-Seq_EML_Mouse0.82833034
105GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82672782
106GATA2_19941826_ChIP-Seq_K562_Human0.82228205
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.81633197
108SA1_27219007_Chip-Seq_Bcells_Human0.81202003
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81124902
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80932857
111SCL_19346495_ChIP-Seq_HPC-7_Human0.80797561
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79412209
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79033003
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78884452
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78759082
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.78570784
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78401565
118SPI1_20517297_ChIP-Seq_HL60_Human0.78155937
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77979668
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77584289
121PU1_27457419_Chip-Seq_LIVER_Mouse0.77038991
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77020617
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.76757975
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76428851
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75974810
126STAT1_20625510_ChIP-Seq_HELA_Human0.75654404
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.75451820
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75328357
129FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73457077
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.73218387
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.72354732
132P53_22387025_ChIP-Seq_ESCs_Mouse0.72248901
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71660860
134NMYC_18555785_Chip-Seq_ESCs_Mouse0.71423652
135SUZ12_18555785_Chip-Seq_ESCs_Mouse0.71090764
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.69871128
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.69737516
138GATA3_21867929_ChIP-Seq_TH1_Mouse0.68356092
139KDM2B_26808549_Chip-Seq_REH_Human0.68057562
140ESRRB_18555785_Chip-Seq_ESCs_Mouse0.68015246
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67802309
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67492830
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.66625695
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.66560200
145STAT1_17558387_ChIP-Seq_HELA_Human0.66240305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.15751639
2MP0005410_abnormal_fertilization4.38187252
3MP0009785_altered_susceptibility_to4.15026522
4MP0000685_abnormal_immune_system3.75225679
5MP0002148_abnormal_hypersensitivity_rea3.64799666
6MP0005671_abnormal_response_to3.55221827
7MP0003436_decreased_susceptibility_to3.41642779
8MP0006082_CNS_inflammation3.32160821
9MP0005000_abnormal_immune_tolerance3.21834335
10MP0005387_immune_system_phenotype3.16846460
11MP0001790_abnormal_immune_system3.16846460
12MP0004510_myositis3.01336189
13MP0005025_abnormal_response_to2.92991378
14MP0002138_abnormal_hepatobiliary_system2.81886629
15MP0001800_abnormal_humoral_immune2.81854328
16MP0002723_abnormal_immune_serum2.72233768
17MP0002452_abnormal_antigen_presenting2.62441024
18MP0002006_tumorigenesis2.61747776
19MP0002419_abnormal_innate_immunity2.56366164
20MP0001348_abnormal_lacrimal_gland2.53895051
21MP0001819_abnormal_immune_cell2.43463303
22MP0002163_abnormal_gland_morphology2.41986289
23MP0002420_abnormal_adaptive_immunity2.38691775
24MP0002166_altered_tumor_susceptibility2.34907190
25MP0002254_reproductive_system_inflammat2.16329763
26MP0003303_peritoneal_inflammation2.08469667
27MP0003724_increased_susceptibility_to2.04203003
28MP0008004_abnormal_stomach_pH2.04133497
29MP0005310_abnormal_salivary_gland1.97607960
30MP0002398_abnormal_bone_marrow1.91247041
31MP0003448_altered_tumor_morphology1.88247799
32MP0000716_abnormal_immune_system1.88023178
33MP0002405_respiratory_system_inflammati1.87628459
34MP0009333_abnormal_splenocyte_physiolog1.84460644
35MP0004947_skin_inflammation1.83027015
36MP0003763_abnormal_thymus_physiology1.72344101
37MP0010155_abnormal_intestine_physiology1.70838449
38MP0001845_abnormal_inflammatory_respons1.70067905
39MP0002132_abnormal_respiratory_system1.64530311
40MP0001873_stomach_inflammation1.62317055
41MP0001533_abnormal_skeleton_physiology1.57590744
42MP0008469_abnormal_protein_level1.56942949
43MP0002429_abnormal_blood_cell1.45120081
44MP0000569_abnormal_digit_pigmentation1.43031330
45MP0001853_heart_inflammation1.42140954
46MP0001346_abnormal_lacrimal_gland1.41914361
47MP0009764_decreased_sensitivity_to1.41777535
48MP0005464_abnormal_platelet_physiology1.39799471
49MP0003172_abnormal_lysosome_physiology1.33416677
50MP0002722_abnormal_immune_system1.32118640
51MP0005397_hematopoietic_system_phenotyp1.31763689
52MP0001545_abnormal_hematopoietic_system1.31763689
53MP0000689_abnormal_spleen_morphology1.29673036
54MP0002277_abnormal_respiratory_mucosa1.28773506
55MP0000858_altered_metastatic_potential1.26212632
56MP0004130_abnormal_muscle_cell1.23473330
57MP0003091_abnormal_cell_migration1.20397597
58MP0003698_abnormal_male_reproductive1.16771516
59MP0005379_endocrine/exocrine_gland_phen1.14034115
60MP0006054_spinal_hemorrhage1.12747181
61MP0002998_abnormal_bone_remodeling1.10982194
62MP0005058_abnormal_lysosome_morphology1.10207240
63MP0002009_preneoplasia1.10017779
64MP0009278_abnormal_bone_marrow1.04980368
65MP0001929_abnormal_gametogenesis1.04087033
66MP0000703_abnormal_thymus_morphology1.00534133
67MP0003045_fibrosis0.98665994
68MP0009763_increased_sensitivity_to0.97870829
69MP0010307_abnormal_tumor_latency0.94498699
70MP0003300_gastrointestinal_ulcer0.92653527
71MP0005451_abnormal_body_composition0.92601038
72MP0004381_abnormal_hair_follicle0.90384759
73MP0004808_abnormal_hematopoietic_stem0.89905114
74MP0003183_abnormal_peptide_metabolism0.87047587
75MP0010352_gastrointestinal_tract_polyps0.86277331
76MP0000465_gastrointestinal_hemorrhage0.86195640
77MP0003195_calcinosis0.81092347
78MP0000604_amyloidosis0.80034427
79MP0002933_joint_inflammation0.79082380
80MP0005167_abnormal_blood-brain_barrier0.74694739
81MP0005023_abnormal_wound_healing0.73797264
82MP0005083_abnormal_biliary_tract0.72545016
83MP0003075_altered_response_to0.72348874
84MP0001661_extended_life_span0.72223059
85MP0002736_abnormal_nociception_after0.70308897
86MP0003866_abnormal_defecation0.69149653
87MP0009765_abnormal_xenobiotic_induced0.68468285
88MP0005166_decreased_susceptibility_to0.67956949
89MP0001919_abnormal_reproductive_system0.67384955
90MP0000343_altered_response_to0.67377323
91MP0001881_abnormal_mammary_gland0.66760463
92MP0008057_abnormal_DNA_replication0.66114667
93MP0000230_abnormal_systemic_arterial0.65772954
94MP0000490_abnormal_crypts_of0.65534397
95MP0003566_abnormal_cell_adhesion0.64290187
96MP0001501_abnormal_sleep_pattern0.64096904
97MP0001986_abnormal_taste_sensitivity0.63984836
98MP0005174_abnormal_tail_pigmentation0.63460332
99MP0002653_abnormal_ependyma_morphology0.62926969
100MP0000249_abnormal_blood_vessel0.61535940
101MP0003453_abnormal_keratinocyte_physiol0.61326088
102MP0005084_abnormal_gallbladder_morpholo0.60293770
103MP0002136_abnormal_kidney_physiology0.59980887
104MP0008874_decreased_physiological_sensi0.59572380
105MP0005390_skeleton_phenotype0.58561706
106MP0001851_eye_inflammation0.57846987
107MP0002168_other_aberrant_phenotype0.55909841
108MP0009642_abnormal_blood_homeostasis0.55657894
109MP0001968_abnormal_touch/_nociception0.54926161
110MP0003646_muscle_fatigue0.54900341
111MP0005535_abnormal_body_temperature0.54255189
112MP0005076_abnormal_cell_differentiation0.52007823
113MP0005584_abnormal_enzyme/coenzyme_acti0.52007119
114MP0002693_abnormal_pancreas_physiology0.51973297
115MP0002877_abnormal_melanocyte_morpholog0.51825549
116MP0002161_abnormal_fertility/fecundity0.51242198
117MP0002019_abnormal_tumor_incidence0.49098586
118MP0005381_digestive/alimentary_phenotyp0.49065042
119MP0003638_abnormal_response/metabolism_0.48075858
120MP0009643_abnormal_urine_homeostasis0.47931416
121MP0003186_abnormal_redox_activity0.47462066
122MP0000627_abnormal_mammary_gland0.44512749
123MP0008877_abnormal_DNA_methylation0.44274120
124MP0001765_abnormal_ion_homeostasis0.43511068
125MP0005623_abnormal_meninges_morphology0.42723989
126MP0002928_abnormal_bile_duct0.41095837
127MP0001663_abnormal_digestive_system0.38845690
128MP0002210_abnormal_sex_determination0.38568922
129MP0002396_abnormal_hematopoietic_system0.38272184
130MP0000920_abnormal_myelination0.37848344
131MP0000613_abnormal_salivary_gland0.36329370

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.31028971
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.81299403
3Absent/shortened dynein arms (HP:0200106)5.81299403
4Abnormality of the nasal mucosa (HP:0000433)5.17152458
5Prolonged bleeding time (HP:0003010)5.02340663
6Recurrent abscess formation (HP:0002722)4.99068691
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.98663231
8Gastrointestinal infarctions (HP:0005244)4.94470608
9Recurrent bacterial skin infections (HP:0005406)4.87659187
10Eczematoid dermatitis (HP:0000976)4.87594914
11Optic neuritis (HP:0100653)4.67832847
12Retrobulbar optic neuritis (HP:0100654)4.67832847
13Increased IgM level (HP:0003496)4.59482310
14Orchitis (HP:0100796)4.44529423
15Myositis (HP:0100614)4.31371711
16Autoimmune thrombocytopenia (HP:0001973)4.25097494
17Epistaxis (HP:0000421)4.23704983
18Elevated erythrocyte sedimentation rate (HP:0003565)4.14431230
19Purpura (HP:0000979)4.10065294
20Recurrent fungal infections (HP:0002841)4.07223379
21Vasculitis (HP:0002633)4.04383795
22Recurrent viral infections (HP:0004429)3.92475355
23Menorrhagia (HP:0000132)3.91958180
24Aplastic anemia (HP:0001915)3.89802207
25Chronic otitis media (HP:0000389)3.88447432
26Abnormality of T cell number (HP:0011839)3.87943521
27Petechiae (HP:0000967)3.83984399
28Mediastinal lymphadenopathy (HP:0100721)3.79117153
29Recurrent bronchitis (HP:0002837)3.76386170
30Abnormal respiratory epithelium morphology (HP:0012253)3.54750521
31Abnormal respiratory motile cilium morphology (HP:0005938)3.54750521
32Recurrent gram-negative bacterial infections (HP:0005420)3.51838452
33Abnormal platelet volume (HP:0011876)3.50921799
34Abnormal respiratory motile cilium physiology (HP:0012261)3.49421724
35T lymphocytopenia (HP:0005403)3.47353523
36Abnormality of macrophages (HP:0004311)3.46233533
37Spontaneous hematomas (HP:0007420)3.42938450
38Increased mean platelet volume (HP:0011877)3.40063463
39Hypoproteinemia (HP:0003075)3.34688825
40Hypergammaglobulinemia (HP:0010702)3.34154766
41Recurrent skin infections (HP:0001581)3.33551517
42Bronchitis (HP:0012387)3.30098881
43Generalized aminoaciduria (HP:0002909)3.18406237
44Fatigue (HP:0012378)3.14032898
45Gingivitis (HP:0000230)3.10987082
46Pustule (HP:0200039)3.10688913
47Tetraparesis (HP:0002273)3.07640561
48Recurrent cutaneous fungal infections (HP:0011370)3.05211653
49Chronic mucocutaneous candidiasis (HP:0002728)3.05211653
50Bronchiectasis (HP:0002110)3.04590329
51Acute hepatic failure (HP:0006554)3.03852175
52Arterial thrombosis (HP:0004420)2.96626351
53Pulmonary infiltrates (HP:0002113)2.91238339
54Leukocytosis (HP:0001974)2.90528715
55Rhinitis (HP:0012384)2.89325439
56Increased IgE level (HP:0003212)2.89032170
57Chronic sinusitis (HP:0011109)2.84656642
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.84428537
59Abnormality of the common coagulation pathway (HP:0010990)2.83873095
60Abnormal ciliary motility (HP:0012262)2.82597850
61Hemoptysis (HP:0002105)2.81558105
62Periodontitis (HP:0000704)2.80692304
63Keratoconjunctivitis sicca (HP:0001097)2.79069924
64Recurrent sinusitis (HP:0011108)2.70919150
65Basal ganglia calcification (HP:0002135)2.67858946
66Dyschromatopsia (HP:0007641)2.66857291
67Myocardial infarction (HP:0001658)2.65719002
68Eosinophilia (HP:0001880)2.64476542
69Joint swelling (HP:0001386)2.63886342
70Abnormality of the prostate (HP:0008775)2.61950370
71Stomatitis (HP:0010280)2.61795156
72Chronic bronchitis (HP:0004469)2.60667947
73Infertility (HP:0000789)2.59347468
74Porencephaly (HP:0002132)2.58835895
75Abnormality of the costochondral junction (HP:0000919)2.54360556
76Osteolytic defects of the hand bones (HP:0009699)2.53290732
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.53290732
78Keratoconjunctivitis (HP:0001096)2.53013448
79Thick nail (HP:0001805)2.52835031
80Pulmonary embolism (HP:0002204)2.51881702
81Abnormality of eosinophils (HP:0001879)2.51681323
82Hyperlipoproteinemia (HP:0010980)2.51583514
83Gingival bleeding (HP:0000225)2.48066043
84Increased serum ferritin (HP:0003281)2.47200882
85Abnormality of T cells (HP:0002843)2.46967583
86Chest pain (HP:0100749)2.44512265
87Autoimmune hemolytic anemia (HP:0001890)2.43266501
88Chronic diarrhea (HP:0002028)2.41256435
89Lymphoma (HP:0002665)2.36617060
90Hemiplegia (HP:0002301)2.34031251
91Polyneuropathy (HP:0001271)2.33927066
92Meningitis (HP:0001287)2.33548414
93Peritonitis (HP:0002586)2.32309071
94Loss of speech (HP:0002371)2.30431270
95Glomerulopathy (HP:0100820)2.29074168
96Abnormal platelet function (HP:0011869)2.25855912
97Impaired platelet aggregation (HP:0003540)2.25855912
98Encephalitis (HP:0002383)2.25846801
99Abnormality of binocular vision (HP:0011514)2.23946104
100Diplopia (HP:0000651)2.23946104
101Male infertility (HP:0003251)2.23798356
102Chronic obstructive pulmonary disease (HP:0006510)2.21248572
103Obstructive lung disease (HP:0006536)2.21248572
104Anorexia (HP:0002039)2.18430063
105Amaurosis fugax (HP:0100576)2.17234959
106Granulocytopenia (HP:0001913)2.17138144
107Abnormal albumin level (HP:0012116)2.16037719
108Hypoalbuminemia (HP:0003073)2.16037719
109Renal Fanconi syndrome (HP:0001994)2.14538929
110Abnormality of iron homeostasis (HP:0011031)2.14420125
111Severe combined immunodeficiency (HP:0004430)2.13072276
112Abnormality of the pericardium (HP:0001697)2.11991696
113Joint hemorrhage (HP:0005261)2.11751547
114Thyroiditis (HP:0100646)2.11263657
115Abnormality of cells of the lymphoid lineage (HP:0012140)2.10785896
116Hypophosphatemic rickets (HP:0004912)2.10736139
117Inflammation of the large intestine (HP:0002037)2.09399088
118Interstitial pulmonary disease (HP:0006530)2.09298588
119Thrombocytosis (HP:0001894)2.09158802
120Gangrene (HP:0100758)2.07119057
121Combined immunodeficiency (HP:0005387)2.05715202
122Cleft eyelid (HP:0000625)2.04224675
123Abnormal spermatogenesis (HP:0008669)2.02297869
124Ureteral stenosis (HP:0000071)2.00436632
125Abnormality of lateral ventricle (HP:0030047)1.98660059
126Agammaglobulinemia (HP:0004432)1.98462633
127Arthralgia (HP:0002829)1.96228018
128Lymphopenia (HP:0001888)1.95027094
129Cellulitis (HP:0100658)1.94219384
130Prostate neoplasm (HP:0100787)1.93999130
131Hypochromic microcytic anemia (HP:0004840)1.93831716
132Ureteral obstruction (HP:0006000)1.93180160
133Thin bony cortex (HP:0002753)1.92996665
134Hypochromic anemia (HP:0001931)1.92362307
135Recurrent otitis media (HP:0000403)1.92186671
136Abnormality of transition element cation homeostasis (HP:0011030)1.91896161
137Colitis (HP:0002583)1.88509514
138Gastrointestinal inflammation (HP:0004386)1.88081491
139IgG deficiency (HP:0004315)1.86101403
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84196966
141Absent frontal sinuses (HP:0002688)1.84122687
142Cerebral hemorrhage (HP:0001342)1.83932990
143Abnormality of the pleura (HP:0002103)1.83341186
144Hyponatremia (HP:0002902)1.81448151
145Skin rash (HP:0000988)1.80691335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.39166120
2TESK24.26443197
3MAP3K134.12115201
4TYK23.94039305
5JAK33.50082993
6KDR3.45989901
7TLK13.39431035
8JAK13.33465416
9TBK12.86387267
10PBK2.82144527
11ZAK2.79628291
12IKBKE2.64046319
13PDK42.60542090
14PDK32.60542090
15IKBKB2.56361117
16RIPK42.51165688
17TESK12.27361964
18TXK2.23200067
19IRAK42.17487779
20FGFR42.11364968
21EPHA32.06771191
22CHUK2.02970632
23MAP4K12.02326894
24TNK21.97006402
25CAMKK21.89304728
26IRAK11.87731885
27EPHB11.79678329
28SIK21.69668143
29ARAF1.65386025
30VRK11.64828501
31MST41.61221588
32CSK1.60779079
33PDK21.54403180
34RPS6KA41.39839780
35BLK1.36191709
36PIM21.32071430
37KIT1.31559782
38STK41.25625337
39FGFR31.25045464
40SYK1.17754780
41LCK1.13207099
42IRAK31.08011804
43PIM11.06932263
44NLK1.04707502
45HCK1.04304224
46JAK21.03149288
47NEK91.01718383
48ZAP701.00599395
49ITK0.99425370
50IRAK20.98701969
51PRKCQ0.98627478
52PIK3CG0.96678468
53PKN10.95947278
54CSF1R0.90285823
55NEK20.89764277
56BMPR20.89220228
57ICK0.88770919
58PAK10.88489021
59FYN0.86284774
60LIMK10.84729227
61FGR0.83204381
62EIF2AK20.80172525
63MARK30.79251188
64MAPK150.79106913
65PRKD30.77961410
66TEC0.76553004
67STK100.75397994
68MYLK0.75138541
69MAPKAPK30.74699601
70BTK0.68660547
71STK30.67059305
72GRK60.66933467
73MAP3K110.65636213
74MAPK110.65500359
75SIK30.64680918
76MAP3K90.63167478
77CAMKK10.62646401
78GRK50.62529481
79PTK2B0.60949441
80LYN0.58812563
81PDK10.58582230
82TAOK30.57112366
83TAOK20.56489190
84MATK0.51526371
85DYRK1B0.51167294
86NUAK10.50703312
87PRKCD0.50151505
88MAP3K30.49840451
89PDGFRB0.49276860
90ADRBK20.49175133
91CLK10.47980642
92MAP2K30.47082949
93MOS0.46074754
94TRPM70.43525316
95YES10.41913088
96BMX0.41522407
97KSR20.41194143
98TAOK10.40979218
99PRKAA20.39968923
100PRKCH0.39812500
101FES0.39536051
102EGFR0.39177254
103TYRO30.37617424
104GRK70.37332716
105ABL10.35888109
106ERN10.35493612
107WNK10.35364934
108GRK10.33699940
109MAPKAPK20.33182323
110PRKD10.32872961
111MAPK120.32699101
112INSR0.32334377
113RAF10.32094259
114ERBB20.31232171
115MAP3K50.31000861
116IGF1R0.29706040
117STK380.29280931
118TTN0.28899811
119MAPK130.28659736
120RPS6KA10.27909204
121CAMK2A0.27780532
122PTK60.26977751
123MAP3K10.26781967
124PRKCA0.26676243
125ROCK10.26262920
126MAP3K100.26088351
127PRKCB0.25427074
128OXSR10.25330984
129PRKACG0.24810928
130STK240.24058849
131ALK0.23886732
132ADRBK10.23377905
133MUSK0.21980989
134FLT30.21060949
135WNK40.20422174
136SRC0.20274499
137BUB10.19794469
138HIPK20.19266138
139CDK120.18900693
140RPS6KA50.18221616
141RET0.17939401
142MAP2K60.16065877

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.16634257
2Allograft rejection_Homo sapiens_hsa053303.89758578
3Leishmaniasis_Homo sapiens_hsa051402.92362533
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.90689662
5Measles_Homo sapiens_hsa051622.87818164
6Type I diabetes mellitus_Homo sapiens_hsa049402.74012195
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59540669
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.58288269
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51186315
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.50570801
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38127122
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34855853
13Antigen processing and presentation_Homo sapiens_hsa046122.32393779
14Influenza A_Homo sapiens_hsa051642.19847437
15TNF signaling pathway_Homo sapiens_hsa046682.15574199
16Legionellosis_Homo sapiens_hsa051342.09038321
17Osteoclast differentiation_Homo sapiens_hsa043802.08069045
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06651347
19Herpes simplex infection_Homo sapiens_hsa051681.98742758
20Primary immunodeficiency_Homo sapiens_hsa053401.91330600
21African trypanosomiasis_Homo sapiens_hsa051431.90958925
22Autoimmune thyroid disease_Homo sapiens_hsa053201.90889771
23Toxoplasmosis_Homo sapiens_hsa051451.89006459
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.86038981
25Rheumatoid arthritis_Homo sapiens_hsa053231.65691178
26Chemokine signaling pathway_Homo sapiens_hsa040621.64723970
27Malaria_Homo sapiens_hsa051441.59610388
28Pertussis_Homo sapiens_hsa051331.55771401
29Viral myocarditis_Homo sapiens_hsa054161.55594813
30Tuberculosis_Homo sapiens_hsa051521.53489939
31T cell receptor signaling pathway_Homo sapiens_hsa046601.52406398
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45983595
33B cell receptor signaling pathway_Homo sapiens_hsa046621.42167569
34Apoptosis_Homo sapiens_hsa042101.39345034
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28730346
36Staphylococcus aureus infection_Homo sapiens_hsa051501.28019053
37Salmonella infection_Homo sapiens_hsa051321.27209006
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22212292
39Hematopoietic cell lineage_Homo sapiens_hsa046401.20196077
40Nitrogen metabolism_Homo sapiens_hsa009101.13274901
41Shigellosis_Homo sapiens_hsa051311.11130747
42Hepatitis C_Homo sapiens_hsa051601.04632265
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00086177
44Hepatitis B_Homo sapiens_hsa051610.97479773
45Asthma_Homo sapiens_hsa053100.95862744
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88517443
47Prolactin signaling pathway_Homo sapiens_hsa049170.81726661
48Acute myeloid leukemia_Homo sapiens_hsa052210.77372910
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.77218028
50Epstein-Barr virus infection_Homo sapiens_hsa051690.76923431
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67079626
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67015227
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65089225
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.60416605
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.60276508
56ABC transporters_Homo sapiens_hsa020100.59328646
57Dorso-ventral axis formation_Homo sapiens_hsa043200.57715471
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56050214
59Amoebiasis_Homo sapiens_hsa051460.49840267
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49742029
61Phagosome_Homo sapiens_hsa041450.48859999
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48659114
63Small cell lung cancer_Homo sapiens_hsa052220.47528678
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47489570
65Viral carcinogenesis_Homo sapiens_hsa052030.47314651
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46313446
67Prion diseases_Homo sapiens_hsa050200.43881437
68Lysosome_Homo sapiens_hsa041420.43645622
69Linoleic acid metabolism_Homo sapiens_hsa005910.43291487
70Platelet activation_Homo sapiens_hsa046110.43258892
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.43038629
72Chronic myeloid leukemia_Homo sapiens_hsa052200.42723828
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40612190
74Pancreatic cancer_Homo sapiens_hsa052120.39604265
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39052855
76HTLV-I infection_Homo sapiens_hsa051660.38688597
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36277536
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33630777
79VEGF signaling pathway_Homo sapiens_hsa043700.33342496
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33196582
81Type II diabetes mellitus_Homo sapiens_hsa049300.33134762
82Arachidonic acid metabolism_Homo sapiens_hsa005900.32095977
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.30138119
84Oxidative phosphorylation_Homo sapiens_hsa001900.29646451
85MAPK signaling pathway_Homo sapiens_hsa040100.28300643
86HIF-1 signaling pathway_Homo sapiens_hsa040660.27414652
87Protein export_Homo sapiens_hsa030600.26715721
88Ras signaling pathway_Homo sapiens_hsa040140.25778614
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25056890
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24543598
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23795565
92Phototransduction_Homo sapiens_hsa047440.23774226
93Rap1 signaling pathway_Homo sapiens_hsa040150.23748704
94Other glycan degradation_Homo sapiens_hsa005110.23434281
95Inositol phosphate metabolism_Homo sapiens_hsa005620.20929098
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20396368
97Regulation of autophagy_Homo sapiens_hsa041400.20265096
98p53 signaling pathway_Homo sapiens_hsa041150.19796923
99Endocytosis_Homo sapiens_hsa041440.19765425
100FoxO signaling pathway_Homo sapiens_hsa040680.19403156
101Olfactory transduction_Homo sapiens_hsa047400.19005438
102Insulin resistance_Homo sapiens_hsa049310.18962744
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.18824469
104Glycerolipid metabolism_Homo sapiens_hsa005610.18483963
105RNA polymerase_Homo sapiens_hsa030200.17529295
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17008607
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15895404
108Calcium signaling pathway_Homo sapiens_hsa040200.14818270
109Fatty acid biosynthesis_Homo sapiens_hsa000610.14517905
110Renin-angiotensin system_Homo sapiens_hsa046140.14231960
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14231955
112Serotonergic synapse_Homo sapiens_hsa047260.13692633
113Alcoholism_Homo sapiens_hsa050340.13483074
114Notch signaling pathway_Homo sapiens_hsa043300.11823305
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11783273
116Mineral absorption_Homo sapiens_hsa049780.10177432
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.09971652
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09930014
119Systemic lupus erythematosus_Homo sapiens_hsa053220.07517804
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06922603
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06836049
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06273782
123Proteasome_Homo sapiens_hsa030500.05767361
124Collecting duct acid secretion_Homo sapiens_hsa04966-0.0084841

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