HEBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97910475
2L-phenylalanine metabolic process (GO:0006558)6.97910475
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97698917
4L-phenylalanine catabolic process (GO:0006559)6.97698917
5sulfur amino acid catabolic process (GO:0000098)6.24556806
6aromatic amino acid family catabolic process (GO:0009074)6.18056526
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.79300589
8proline biosynthetic process (GO:0006561)5.73892640
9glyoxylate metabolic process (GO:0046487)5.67483649
10indole-containing compound catabolic process (GO:0042436)5.45960122
11indolalkylamine catabolic process (GO:0046218)5.45960122
12tryptophan catabolic process (GO:0006569)5.45960122
13kynurenine metabolic process (GO:0070189)5.43329347
14bile acid biosynthetic process (GO:0006699)5.36244556
15proline metabolic process (GO:0006560)5.25723088
16virion attachment to host cell (GO:0019062)5.23303590
17adhesion of symbiont to host cell (GO:0044650)5.23303590
18cysteine metabolic process (GO:0006534)5.17989014
19angiotensin maturation (GO:0002003)5.13614532
20alpha-linolenic acid metabolic process (GO:0036109)5.12878975
21tryptophan metabolic process (GO:0006568)5.10673735
22urea metabolic process (GO:0019627)5.08937991
23urea cycle (GO:0000050)5.08937991
24negative regulation of fibrinolysis (GO:0051918)5.02234413
25serine family amino acid catabolic process (GO:0009071)5.00446111
26high-density lipoprotein particle remodeling (GO:0034375)4.95511520
27bile acid metabolic process (GO:0008206)4.89230199
28triglyceride homeostasis (GO:0070328)4.87679091
29acylglycerol homeostasis (GO:0055090)4.87679091
30protein carboxylation (GO:0018214)4.83437804
31peptidyl-glutamic acid carboxylation (GO:0017187)4.83437804
32complement activation, alternative pathway (GO:0006957)4.81204933
33regulation of fibrinolysis (GO:0051917)4.78336397
34negative regulation of fatty acid biosynthetic process (GO:0045717)4.78007494
35nitrogen cycle metabolic process (GO:0071941)4.76250606
36very-low-density lipoprotein particle assembly (GO:0034379)4.75740918
37regulation of protein activation cascade (GO:2000257)4.72614633
38glutamine family amino acid biosynthetic process (GO:0009084)4.62528364
39adhesion of symbiont to host (GO:0044406)4.61842789
40aromatic amino acid family metabolic process (GO:0009072)4.52912921
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46203212
42regulation of complement activation (GO:0030449)4.42178996
43alpha-amino acid catabolic process (GO:1901606)4.34856318
44regulation of triglyceride catabolic process (GO:0010896)4.34488048
45fat-soluble vitamin biosynthetic process (GO:0042362)4.34120871
46cholesterol efflux (GO:0033344)4.33400192
47heme transport (GO:0015886)4.32523936
48regulation of cholesterol esterification (GO:0010872)4.32096472
49lysine metabolic process (GO:0006553)4.27705804
50lysine catabolic process (GO:0006554)4.27705804
51reverse cholesterol transport (GO:0043691)4.27341058
52plasma lipoprotein particle assembly (GO:0034377)4.25429286
53homocysteine metabolic process (GO:0050667)4.24400306
54tyrosine metabolic process (GO:0006570)4.23142706
55protein-lipid complex remodeling (GO:0034368)4.21042682
56macromolecular complex remodeling (GO:0034367)4.21042682
57plasma lipoprotein particle remodeling (GO:0034369)4.21042682
58plasma lipoprotein particle clearance (GO:0034381)4.18191043
59glycine metabolic process (GO:0006544)4.16908831
60cytolysis (GO:0019835)4.15551835
61cellular amino acid catabolic process (GO:0009063)4.11508894
62amino-acid betaine metabolic process (GO:0006577)4.11479898
63alkaloid metabolic process (GO:0009820)4.08149191
64serine family amino acid metabolic process (GO:0009069)4.06258324
65negative regulation of sterol transport (GO:0032372)4.05646779
66negative regulation of cholesterol transport (GO:0032375)4.05646779
67acetyl-CoA metabolic process (GO:0006084)4.03138261
68phospholipid efflux (GO:0033700)3.99441986
69NADH metabolic process (GO:0006734)3.99201690
70regulation of cholesterol homeostasis (GO:2000188)3.97436730
71imidazole-containing compound metabolic process (GO:0052803)3.94855121
72glycosphingolipid catabolic process (GO:0046479)3.87805281
73glutamate metabolic process (GO:0006536)3.83460828
74regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.82284524
75protein-lipid complex assembly (GO:0065005)3.81933879
76coenzyme catabolic process (GO:0009109)3.81877668
77ethanol oxidation (GO:0006069)3.80956320
78cellular ketone body metabolic process (GO:0046950)3.80531715
79epoxygenase P450 pathway (GO:0019373)3.80023668
80cellular biogenic amine catabolic process (GO:0042402)3.78396401
81amine catabolic process (GO:0009310)3.78396401
82indolalkylamine metabolic process (GO:0006586)3.75618865
83bile acid and bile salt transport (GO:0015721)3.75168923
84intestinal cholesterol absorption (GO:0030299)3.72208164
85serine family amino acid biosynthetic process (GO:0009070)3.71019415
86cholesterol homeostasis (GO:0042632)3.70664465
87transcription from mitochondrial promoter (GO:0006390)3.70031927
88barbed-end actin filament capping (GO:0051016)3.68712939
89glycolipid catabolic process (GO:0019377)3.68569483
90cellular glucuronidation (GO:0052695)3.64574162
91sterol homeostasis (GO:0055092)3.64093651
92arginine metabolic process (GO:0006525)3.64000611
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.62464795
94organic acid catabolic process (GO:0016054)3.61329313
95carboxylic acid catabolic process (GO:0046395)3.61329313
96cellular modified amino acid catabolic process (GO:0042219)3.61100356
97NAD biosynthetic process (GO:0009435)3.58723682
98aldehyde catabolic process (GO:0046185)3.57484342
99benzene-containing compound metabolic process (GO:0042537)3.57475692
100plasma lipoprotein particle organization (GO:0071827)3.56602196
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.56357392
102pyridine nucleotide biosynthetic process (GO:0019363)3.56357392
103dicarboxylic acid biosynthetic process (GO:0043650)3.54295778
104cyclooxygenase pathway (GO:0019371)3.53355165
105negative regulation of fatty acid metabolic process (GO:0045922)3.52604364
106drug catabolic process (GO:0042737)3.51570364
107fibrinolysis (GO:0042730)3.51230390
108cofactor catabolic process (GO:0051187)3.49537205
109fatty acid beta-oxidation (GO:0006635)3.49048743
110positive regulation of lipoprotein lipase activity (GO:0051006)3.48158666
111positive regulation of triglyceride lipase activity (GO:0061365)3.48158666
112positive regulation of lipid catabolic process (GO:0050996)3.46599987
113renal system process involved in regulation of blood volume (GO:0001977)3.41237358
114low-density lipoprotein particle remodeling (GO:0034374)3.40263735
115protein retention in ER lumen (GO:0006621)3.37583340
116L-ascorbic acid metabolic process (GO:0019852)3.35782239
117fructose metabolic process (GO:0006000)3.27316951
118ceramide catabolic process (GO:0046514)3.11321148
119regulation of mononuclear cell migration (GO:0071675)3.08385195
120maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05047668
121peptide catabolic process (GO:0043171)2.99711076
122glycoside metabolic process (GO:0016137)2.99304076
123xenobiotic catabolic process (GO:0042178)2.97488911
124heme metabolic process (GO:0042168)2.96394791
125protoporphyrinogen IX metabolic process (GO:0046501)2.91926837
126protoporphyrinogen IX biosynthetic process (GO:0006782)2.85836282
127positive regulation of triglyceride metabolic process (GO:0090208)2.82247270
128oligosaccharide catabolic process (GO:0009313)2.81652151
129hydrogen peroxide catabolic process (GO:0042744)2.80952138
130regulation of early endosome to late endosome transport (GO:2000641)2.75243328
131glutathione metabolic process (GO:0006749)2.75045339
132regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73944553
133membrane lipid catabolic process (GO:0046466)2.71695933
134heme biosynthetic process (GO:0006783)2.71411452
135sphingolipid catabolic process (GO:0030149)2.69974320
136nonribosomal peptide biosynthetic process (GO:0019184)2.69115546
137hemoglobin metabolic process (GO:0020027)2.67700476
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67492673
139cellular response to arsenic-containing substance (GO:0071243)2.65687479
140hormone catabolic process (GO:0042447)2.65538882
141regulation of vitamin metabolic process (GO:0030656)2.64954569
142positive regulation of cellular amine metabolic process (GO:0033240)2.64816897
143positive regulation of fatty acid biosynthetic process (GO:0045723)2.64149916
144response to nitrosative stress (GO:0051409)2.63359568
145cellular response to thyroid hormone stimulus (GO:0097067)2.62755662
146drug metabolic process (GO:0017144)2.62529100
147arachidonic acid metabolic process (GO:0019369)2.61720003
148negative regulation of smooth muscle cell migration (GO:0014912)2.57219129
149tooth mineralization (GO:0034505)2.56359645
150renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.53213409
151glutathione derivative metabolic process (GO:1901685)2.53155433
152glutathione derivative biosynthetic process (GO:1901687)2.53155433
153lipoprotein transport (GO:0042953)2.52092241
154porphyrin-containing compound metabolic process (GO:0006778)2.49140142
155fibril organization (GO:0097435)2.48316467
156extracellular fibril organization (GO:0043206)2.46812456
157pinocytosis (GO:0006907)2.46644709
158hyaluronan catabolic process (GO:0030214)2.46375215
159protein neddylation (GO:0045116)2.46060655
160positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.45835755
161glutathione biosynthetic process (GO:0006750)2.45477799
162intestinal absorption (GO:0050892)2.43830464
163regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40534546
164fat-soluble vitamin metabolic process (GO:0006775)2.40289518
165protein maturation by protein folding (GO:0022417)2.38430511
166omega-hydroxylase P450 pathway (GO:0097267)2.38197624
167regulation of cholesterol storage (GO:0010885)2.36237771
168regulation of response to osmotic stress (GO:0047484)2.34195818
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.33654830
170regulation of monocyte chemotaxis (GO:0090025)2.32823465
171vitamin biosynthetic process (GO:0009110)2.31996054
172low-density lipoprotein particle clearance (GO:0034383)2.31972838
173amyloid precursor protein catabolic process (GO:0042987)2.31809034
174regulation of guanylate cyclase activity (GO:0031282)2.31571563
175cellular response to cadmium ion (GO:0071276)2.31143464
176regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30892052
177ethanol metabolic process (GO:0006067)2.30851553
178response to thyroid hormone (GO:0097066)2.29567009
179porphyrin-containing compound biosynthetic process (GO:0006779)2.29522851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.56810052
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.35304277
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.22810054
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.54800035
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.23042109
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80507013
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64557735
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.37645805
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.60782909
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59613967
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94940064
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05589556
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.03788111
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98836738
15* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82755728
16* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76280936
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72446352
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.71485144
19RXRA_24833708_ChIP-Seq_LIVER_Mouse1.70089496
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66957400
21LXR_22292898_ChIP-Seq_THP-1_Human1.65786825
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65407906
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60316912
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58056855
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.57266370
26ZNF263_19887448_ChIP-Seq_K562_Human1.55913168
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48954820
28CTCF_18555785_ChIP-Seq_MESCs_Mouse1.41643062
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40332537
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39412666
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39412666
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39412666
33P68_20966046_ChIP-Seq_HELA_Human1.38702077
34* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38661271
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37929512
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.37682638
37VDR_24763502_ChIP-Seq_THP-1_Human1.34484441
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31867036
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31074663
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30639647
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29480616
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29401642
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29014724
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.28002573
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27310337
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23931435
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23349948
48CLOCK_20551151_ChIP-Seq_293T_Human1.23102833
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22718329
50SA1_27219007_Chip-Seq_Bcells_Human1.20402263
51RARA_24833708_ChIP-Seq_LIVER_Mouse1.20007114
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20005073
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19773922
54RARB_24833708_ChIP-Seq_LIVER_Mouse1.19371233
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18654970
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17243110
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16961334
58* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16455750
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15923416
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15348826
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.15097328
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.13722417
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12290246
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10870099
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.10460161
66SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10111749
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09738624
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08771899
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.08454364
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07471277
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.07447086
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07417292
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06825267
74RACK7_27058665_Chip-Seq_MCF-7_Human1.06533713
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06320016
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05127750
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04725678
78SOX2_20726797_ChIP-Seq_SW620_Human1.04540061
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04299334
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03858390
81CTCF_21964334_Chip-Seq_Bcells_Human1.03472523
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03471781
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.01867140
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01517234
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.01097038
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00108719
87* ATF3_27146783_Chip-Seq_COLON_Human0.99938598
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99846628
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.99744667
90CTCF_20526341_ChIP-Seq_ESCs_Human0.99377600
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99345823
92SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99047426
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98803879
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98276175
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97833743
96GATA1_22025678_ChIP-Seq_K562_Human0.97409177
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97250538
98VDR_21846776_ChIP-Seq_THP-1_Human0.95610845
99KDM2B_26808549_Chip-Seq_K562_Human0.94608442
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94171748
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93805689
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93344583
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93327991
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93173428
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91774438
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91692560
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91081293
108TP53_22127205_ChIP-Seq_IMR90_Human0.90273352
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90090390
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88190841
111BCOR_27268052_Chip-Seq_Bcells_Human0.86839612
112* SPI1_26923725_Chip-Seq_HPCs_Mouse0.84561402
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.83740848
114CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83034683
115ETS1_21867929_ChIP-Seq_TH2_Mouse0.82847158
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82726768
117* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81571178
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.79816245
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79614081
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78829368
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78602451
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76393629
123HTT_18923047_ChIP-ChIP_STHdh_Human0.75687143
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75346511
125POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.75247193
126GATA1_19941826_ChIP-Seq_K562_Human0.74205903
127BCL6_27268052_Chip-Seq_Bcells_Human0.71863514
128E2F1_20622854_ChIP-Seq_HELA_Human0.70390816
129SOX2_18692474_ChIP-Seq_MESCs_Mouse0.69973181
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69791494
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.69565036
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66780956
133NANOG_16518401_ChIP-PET_MESCs_Mouse0.66206761
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64424192
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64098302
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63743254
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63299958
138PHF8_20622854_ChIP-Seq_HELA_Human0.62958484
139CTCF_27219007_Chip-Seq_Bcells_Human0.62872768
140* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.62299664
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.61904044
142STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61635044
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.61457977
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.61288030
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61147254
146STAT1_20625510_ChIP-Seq_HELA_Human0.61067672
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.60590306
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60555658
149CREB1_26743006_Chip-Seq_LNCaP_Human0.60390468
150NANOG_18692474_ChIP-Seq_MESCs_Mouse0.59411915
151NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.59179697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.63151615
2MP0005360_urolithiasis6.95185288
3MP0005085_abnormal_gallbladder_physiolo6.48528551
4MP0005365_abnormal_bile_salt6.20061228
5MP0008875_abnormal_xenobiotic_pharmacok4.63336053
6MP0003806_abnormal_nucleotide_metabolis4.32652539
7MP0010329_abnormal_lipoprotein_level3.34392076
8MP0003252_abnormal_bile_duct3.33274263
9MP0009840_abnormal_foam_cell3.09915526
10MP0005083_abnormal_biliary_tract2.75486961
11MP0005332_abnormal_amino_acid2.67762788
12MP0009379_abnormal_foot_pigmentation2.54646372
13MP0003656_abnormal_erythrocyte_physiolo2.38057167
14MP0008438_abnormal_cutaneous_collagen2.35488222
15MP0003191_abnormal_cellular_cholesterol2.34047002
16MP0004858_abnormal_nervous_system2.30846211
17MP0003195_calcinosis2.29116639
18MP0001666_abnormal_nutrient_absorption2.25474975
19MP0004019_abnormal_vitamin_homeostasis2.25211789
20MP0000609_abnormal_liver_physiology2.17567951
21MP0002118_abnormal_lipid_homeostasis2.09286854
22MP0000343_altered_response_to2.02747851
23MP0005319_abnormal_enzyme/_coenzyme1.81058518
24MP0003183_abnormal_peptide_metabolism1.78219353
25MP0005257_abnormal_intraocular_pressure1.78000910
26MP0001542_abnormal_bone_strength1.76089477
27MP0003279_aneurysm1.74166233
28MP0001764_abnormal_homeostasis1.71468392
29MP0000681_abnormal_thyroid_gland1.66125565
30MP0000678_abnormal_parathyroid_gland1.64194027
31MP0003303_peritoneal_inflammation1.50042212
32MP0002138_abnormal_hepatobiliary_system1.42505789
33MP0005584_abnormal_enzyme/coenzyme_acti1.41805922
34MP0003186_abnormal_redox_activity1.38542953
35MP0008057_abnormal_DNA_replication1.38126059
36MP0003868_abnormal_feces_composition1.36518171
37MP0005647_abnormal_sex_gland1.29285678
38MP0003705_abnormal_hypodermis_morpholog1.29195257
39MP0006054_spinal_hemorrhage1.27344622
40MP0002877_abnormal_melanocyte_morpholog1.26727889
41MP0000598_abnormal_liver_morphology1.23332624
42MP0004272_abnormal_basement_membrane1.20639695
43MP0009278_abnormal_bone_marrow1.20226604
44MP0008004_abnormal_stomach_pH1.18445573
45MP0000858_altered_metastatic_potential1.17912349
46MP0001533_abnormal_skeleton_physiology1.14216529
47MP0002148_abnormal_hypersensitivity_rea1.11680111
48MP0002653_abnormal_ependyma_morphology1.11307675
49MP0001849_ear_inflammation1.11107974
50MP0001881_abnormal_mammary_gland1.10918096
51MP0005165_increased_susceptibility_to1.10574293
52MP0000639_abnormal_adrenal_gland1.09772555
53MP0005670_abnormal_white_adipose1.06564645
54MP0010155_abnormal_intestine_physiology1.06334966
55MP0004130_abnormal_muscle_cell1.03640417
56MP0002971_abnormal_brown_adipose1.03269612
57MP0005508_abnormal_skeleton_morphology1.02916406
58MP0005166_decreased_susceptibility_to1.01898054
59MP0005058_abnormal_lysosome_morphology1.01565686
60MP0003436_decreased_susceptibility_to1.01437413
61MP0005266_abnormal_metabolism1.01402900
62MP0005451_abnormal_body_composition1.01332696
63MP0009643_abnormal_urine_homeostasis1.01260187
64MP0001958_emphysema1.00642845
65MP0001663_abnormal_digestive_system1.00450717
66MP0005390_skeleton_phenotype1.00358983
67MP0002896_abnormal_bone_mineralization0.97854576
68MP0003879_abnormal_hair_cell0.97421826
69MP0005376_homeostasis/metabolism_phenot0.97172728
70MP0006036_abnormal_mitochondrial_physio0.96682848
71MP0000490_abnormal_crypts_of0.95870874
72MP0009697_abnormal_copulation0.95467172
73MP0005171_absent_coat_pigmentation0.94896691
74MP0003329_amyloid_beta_deposits0.94830986
75MP0002998_abnormal_bone_remodeling0.93980638
76MP0003453_abnormal_keratinocyte_physiol0.91883291
77MP0005501_abnormal_skin_physiology0.86808922
78MP0008260_abnormal_autophagy0.86632071
79MP0000579_abnormal_nail_morphology0.86503296
80MP0005023_abnormal_wound_healing0.85998211
81MP0004510_myositis0.85592864
82MP0003011_delayed_dark_adaptation0.84891212
83MP0002254_reproductive_system_inflammat0.83557905
84MP0009115_abnormal_fat_cell0.83358097
85MP0009053_abnormal_anal_canal0.80326506
86MP0005503_abnormal_tendon_morphology0.80198288
87MP0005381_digestive/alimentary_phenotyp0.79643864
88MP0005334_abnormal_fat_pad0.78986512
89MP0009763_increased_sensitivity_to0.78261458
90MP0000604_amyloidosis0.77853336
91MP0001756_abnormal_urination0.77685995
92MP0010030_abnormal_orbit_morphology0.76999327
93MP0005397_hematopoietic_system_phenotyp0.76355737
94MP0001545_abnormal_hematopoietic_system0.76355737
95MP0009764_decreased_sensitivity_to0.76274603
96MP0002796_impaired_skin_barrier0.75736908
97MP0009785_altered_susceptibility_to0.75159949
98MP0003724_increased_susceptibility_to0.74587871
99MP0002295_abnormal_pulmonary_circulatio0.74239831
100MP0009642_abnormal_blood_homeostasis0.73849361
101MP0000538_abnormal_urinary_bladder0.73691951
102MP0003448_altered_tumor_morphology0.73318866
103MP0004782_abnormal_surfactant_physiolog0.71667300
104MP0002009_preneoplasia0.71632562
105MP0002419_abnormal_innate_immunity0.71382364
106MP0009384_cardiac_valve_regurgitation0.70752516
107MP0008995_early_reproductive_senescence0.70576844
108MP0003718_maternal_effect0.70438272
109MP0003075_altered_response_to0.70370408
110MP0002249_abnormal_larynx_morphology0.69297138
111MP0005275_abnormal_skin_tensile0.69205847
112MP0002078_abnormal_glucose_homeostasis0.68077416
113MP0006082_CNS_inflammation0.68064116
114MP0010368_abnormal_lymphatic_system0.67692414
115MP0005595_abnormal_vascular_smooth0.67592943
116MP0009780_abnormal_chondrocyte_physiolo0.65614362
117MP0005636_abnormal_mineral_homeostasis0.65586632
118MP0008469_abnormal_protein_level0.65372670
119MP0003638_abnormal_response/metabolism_0.64583531
120MP0003172_abnormal_lysosome_physiology0.63546126
121MP0002269_muscular_atrophy0.63415323
122MP0002970_abnormal_white_adipose0.63121743
123MP0002282_abnormal_trachea_morphology0.62451999
124MP0005395_other_phenotype0.62337079
125MP0005666_abnormal_adipose_tissue0.61332031
126MP0004233_abnormal_muscle_weight0.60509828
127MP0001661_extended_life_span0.60392806
128MP0005220_abnormal_exocrine_pancreas0.58697739
129MP0003690_abnormal_glial_cell0.58180855
130MP0003890_abnormal_embryonic-extraembry0.56671552
131MP0002060_abnormal_skin_morphology0.56010227
132MP0005464_abnormal_platelet_physiology0.54837397
133MP0005535_abnormal_body_temperature0.54312102
134MP0005075_abnormal_melanosome_morpholog0.53952682
135MP0008874_decreased_physiological_sensi0.53821435
136MP0005448_abnormal_energy_balance0.52463976
137MP0004185_abnormal_adipocyte_glucose0.51726891
138MP0009765_abnormal_xenobiotic_induced0.50981340
139MP0004147_increased_porphyrin_level0.48335130
140MP0008873_increased_physiological_sensi0.47951838
141MP0005248_abnormal_Harderian_gland0.45982793
142MP0001324_abnormal_eye_pigmentation0.45696245
143MP0000371_diluted_coat_color0.45173941
144MP0004264_abnormal_extraembryonic_tissu0.45059365
145MP0002876_abnormal_thyroid_physiology0.44475309
146MP0004133_heterotaxia0.44174560
147MP0002332_abnormal_exercise_endurance0.44162653
148MP0002168_other_aberrant_phenotype0.38892945
149MP0003953_abnormal_hormone_level0.38774639
150MP0001340_abnormal_eyelid_morphology0.38696645
151MP0008872_abnormal_physiological_respon0.37156585
152MP0002132_abnormal_respiratory_system0.36020652
153MP0005330_cardiomyopathy0.35317782

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.97148073
2Intrahepatic cholestasis (HP:0001406)6.64175609
3Deep venous thrombosis (HP:0002625)6.48330219
4Hypobetalipoproteinemia (HP:0003563)6.18806266
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00372050
6Xanthomatosis (HP:0000991)5.64788664
7Prolonged partial thromboplastin time (HP:0003645)5.55178543
8Abnormality of glycolipid metabolism (HP:0010969)5.16569624
9Abnormality of liposaccharide metabolism (HP:0010968)5.16569624
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.16569624
11Hypochromic microcytic anemia (HP:0004840)5.13672581
12Hyperlipoproteinemia (HP:0010980)4.92270863
13Complement deficiency (HP:0004431)4.82540103
14Hypolipoproteinemia (HP:0010981)4.52136500
15Hyperammonemia (HP:0001987)4.42667083
16Joint hemorrhage (HP:0005261)4.14669762
17Dysostosis multiplex (HP:0000943)4.11241363
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10705784
19Vertebral compression fractures (HP:0002953)4.07987504
20Ketosis (HP:0001946)4.07448010
21Hyperglycinemia (HP:0002154)4.03443715
22Epidermoid cyst (HP:0200040)3.95257128
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.83941672
24Hyperglycinuria (HP:0003108)3.82548884
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80402339
26Vacuolated lymphocytes (HP:0001922)3.80181407
27Abnormality of methionine metabolism (HP:0010901)3.80118514
28Hypoalphalipoproteinemia (HP:0003233)3.78491963
29Fat malabsorption (HP:0002630)3.73711834
30Abnormality of serine family amino acid metabolism (HP:0010894)3.67819268
31Abnormality of glycine metabolism (HP:0010895)3.67819268
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67313840
33Abnormality of complement system (HP:0005339)3.65355067
34Abnormality of the common coagulation pathway (HP:0010990)3.60999266
35Abnormality of proline metabolism (HP:0010907)3.54132013
36Abnormality of pyrimidine metabolism (HP:0004353)3.47667199
37Hypoglycemic coma (HP:0001325)3.31045718
38Myocardial infarction (HP:0001658)3.30725310
39Turricephaly (HP:0000262)3.28640459
40Hyperbilirubinemia (HP:0002904)3.21909577
41Ketoacidosis (HP:0001993)3.20292138
42Petechiae (HP:0000967)3.19414564
43Hypercholesterolemia (HP:0003124)3.18681489
44Abnormality of polysaccharide metabolism (HP:0011012)3.17410286
45Abnormality of glycosaminoglycan metabolism (HP:0004371)3.17410286
46Abnormality of mucopolysaccharide metabolism (HP:0011020)3.17410286
47Axonal loss (HP:0003447)3.15917919
48Ileus (HP:0002595)3.08505433
49Increased cerebral lipofuscin (HP:0011813)3.00938129
50Steatorrhea (HP:0002570)2.97095065
51Abnormality of the intrinsic pathway (HP:0010989)2.95683676
52Nausea (HP:0002018)2.92991691
53Abnormality of fatty-acid metabolism (HP:0004359)2.89192000
54Prolonged neonatal jaundice (HP:0006579)2.88516761
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87092280
56Delayed CNS myelination (HP:0002188)2.84459819
57Alopecia of scalp (HP:0002293)2.84090331
58Purpura (HP:0000979)2.84027786
59Protrusio acetabuli (HP:0003179)2.81581522
60Conjugated hyperbilirubinemia (HP:0002908)2.78249070
61Hepatocellular carcinoma (HP:0001402)2.72821567
62Polycythemia (HP:0001901)2.66687534
63Abnormality of nucleobase metabolism (HP:0010932)2.66220891
64Abnormality of serum amino acid levels (HP:0003112)2.65849635
65Loss of speech (HP:0002371)2.63542618
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.62250926
67Hyperparathyroidism (HP:0000843)2.59314498
68Poikilocytosis (HP:0004447)2.58996327
69Opisthotonus (HP:0002179)2.54653380
70Pustule (HP:0200039)2.53344682
71Acanthocytosis (HP:0001927)2.52919030
72Premature rupture of membranes (HP:0001788)2.52706428
73Cholelithiasis (HP:0001081)2.52008296
74Abnormal gallbladder morphology (HP:0012437)2.50870829
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48922309
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.48873766
77Lethargy (HP:0001254)2.47851933
78Abnormal hemoglobin (HP:0011902)2.46986774
79Spastic diplegia (HP:0001264)2.46578754
80Malnutrition (HP:0004395)2.40365487
81Cerebral palsy (HP:0100021)2.39495740
82Spontaneous abortion (HP:0005268)2.39005857
83Systemic lupus erythematosus (HP:0002725)2.37304489
84Pancreatic islet-cell hyperplasia (HP:0004510)2.36753179
85Metabolic acidosis (HP:0001942)2.36042818
86Hypochromic anemia (HP:0001931)2.33656121
87Irritability (HP:0000737)2.32913781
88Skin nodule (HP:0200036)2.31760078
89Nuclear cataract (HP:0100018)2.30997237
90Cervical subluxation (HP:0003308)2.27322154
91Abnormality of purine metabolism (HP:0004352)2.25497737
92Nonimmune hydrops fetalis (HP:0001790)2.25344332
93Abnormality of the fetal cardiovascular system (HP:0010948)2.25204372
94Abnormal umbilical cord blood vessels (HP:0011403)2.25204372
95Single umbilical artery (HP:0001195)2.25204372
96Lower limb hyperreflexia (HP:0002395)2.20896971
97J-shaped sella turcica (HP:0002680)2.20668232
98Abnormal gallbladder physiology (HP:0012438)2.18482156
99Cholecystitis (HP:0001082)2.18482156
100Increased serum ferritin (HP:0003281)2.16514732
101Menorrhagia (HP:0000132)2.15546004
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15282389
103Dicarboxylic aciduria (HP:0003215)2.15282389
104Coronal craniosynostosis (HP:0004440)2.14694758
105Progressive neurologic deterioration (HP:0002344)2.08724045
106Vascular calcification (HP:0004934)2.07460957
107Acute hepatic failure (HP:0006554)2.06248232
108Abnormal enzyme/coenzyme activity (HP:0012379)2.05930633
109Nephritis (HP:0000123)2.05694141
110Reticulocytosis (HP:0001923)2.05642472
111Neonatal onset (HP:0003623)2.03417542
112Cerebral edema (HP:0002181)2.00317918
113Abnormality of the pancreatic islet cells (HP:0006476)1.99838075
114Abnormality of endocrine pancreas physiology (HP:0012093)1.99838075
115Joint stiffness (HP:0001387)1.98504566
116Vomiting (HP:0002013)1.98129826
117Esophageal varix (HP:0002040)1.98121719
118Vaginal fistula (HP:0004320)1.97809405
119Mucopolysacchariduria (HP:0008155)1.97013930
120Urinary glycosaminoglycan excretion (HP:0003541)1.97013930
121Hypoglycemic seizures (HP:0002173)1.96561701
122Abnormality of macrophages (HP:0004311)1.96286807
123Abnormality of iron homeostasis (HP:0011031)1.96227659
124Protuberant abdomen (HP:0001538)1.95035764
125Gout (HP:0001997)1.94988155
126Hypophosphatemia (HP:0002148)1.94777591
127Hemorrhage of the eye (HP:0011885)1.93530902
128Abnormality of transition element cation homeostasis (HP:0011030)1.93382522
129Peritonitis (HP:0002586)1.92981233
130Rickets (HP:0002748)1.92701778
131Ulnar bowing (HP:0003031)1.92508489
132Recurrent gram-negative bacterial infections (HP:0005420)1.92204750
133Abnormality of the gallbladder (HP:0005264)1.90865972
134Abnormality of the umbilical cord (HP:0010881)1.90745405
135Glomerulonephritis (HP:0000099)1.90336785
136Status epilepticus (HP:0002133)1.89468834
137Pathologic fracture (HP:0002756)1.88456388
138Amyloidosis (HP:0011034)1.87617876
139Increased mean platelet volume (HP:0011877)1.87262498
140Increased IgM level (HP:0003496)1.86454762
141Brushfield spots (HP:0001088)1.86092047
142Abdominal distention (HP:0003270)1.85039754
143Hepatosplenomegaly (HP:0001433)1.84462772
144Abnormality of the Achilles tendon (HP:0005109)1.83759650
145Hydroxyprolinuria (HP:0003080)1.83196301
146Thin bony cortex (HP:0002753)1.83066696
147Confusion (HP:0001289)1.78818196
148Cardiomegaly (HP:0001640)1.78550118
149Abnormality of the phalanges of the hallux (HP:0010057)1.75871996
150Wide cranial sutures (HP:0010537)1.75452047
151Bone pain (HP:0002653)1.75093785
152Asymmetric septal hypertrophy (HP:0001670)1.74250856
153Abnormality of the distal phalanges of the toes (HP:0010182)1.73139023
154Achilles tendon contracture (HP:0001771)1.72971734
155Bulbar palsy (HP:0001283)1.72114596
156Multiple lipomas (HP:0001012)1.71429535
157Blue sclerae (HP:0000592)1.70916451
158Diaphragmatic weakness (HP:0009113)1.68502907
159Widely patent fontanelles and sutures (HP:0004492)1.66977414
160Thoracic kyphosis (HP:0002942)1.65234680
161Nephrolithiasis (HP:0000787)1.63659150
162Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63482873
163Macrocytic anemia (HP:0001972)1.63345001
164Fragile skin (HP:0001030)1.62244990
165Metaphyseal irregularity (HP:0003025)1.60291036
166Genu recurvatum (HP:0002816)1.60150607
167Disinhibition (HP:0000734)1.59531945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.20617037
2MAPK154.90240552
3NME24.76914190
4BCKDK4.03860870
5DDR24.00836333
6MAP3K63.84460033
7PINK13.44086913
8MAP3K113.31185357
9TESK13.22216893
10MYLK2.87288020
11IRAK32.76269130
12TESK22.72256569
13SIK12.67196374
14FGR2.36347883
15MATK2.30507598
16LIMK12.20355050
17DYRK1B2.18289647
18EPHB22.16683145
19TYRO32.16238697
20CSK2.15175055
21BMX2.09335292
22ERN12.03875377
23MAPK111.99506168
24DAPK11.97400275
25FGFR41.95034643
26VRK21.92668196
27ARAF1.89999973
28CDK61.76501832
29PDGFRA1.72760496
30MAP3K121.70216734
31TGFBR21.67054051
32PRKD21.66394067
33UHMK11.59814808
34PIM21.55673596
35PAK41.54438025
36ACVR1B1.54183294
37TRIB31.45324606
38YES11.37497348
39PRKG21.33056413
40TBK11.32118129
41GSK3A1.30462988
42AKT31.24552764
43TAOK11.23784190
44ERBB41.23274398
45ILK1.21168018
46MAP3K101.15747789
47PIM11.12462108
48GRK71.12221696
49FLT31.07600834
50RPS6KL11.04750756
51RPS6KC11.04750756
52TRPM71.04572720
53LATS21.03188534
54PRKAA21.01296887
55MAP3K10.97552709
56PRKAA10.97497324
57DAPK30.96997279
58BRAF0.95931026
59CDK70.94650608
60CDK190.93511126
61MUSK0.93231931
62MOS0.92754403
63RPS6KA60.92697337
64PIK3CA0.88612258
65TAOK30.87905505
66RPS6KA20.87298435
67MAP2K20.83156021
68TAOK20.83051166
69EIF2AK10.81428753
70JAK20.81107786
71CAMK2G0.78392134
72ABL20.76385911
73LATS10.74450835
74INSRR0.74018542
75IKBKB0.73345071
76MAPK40.72459916
77PHKG20.71863041
78PHKG10.71863041
79DMPK0.71480718
80PDPK10.71388720
81MTOR0.71375256
82CDC42BPA0.70724181
83LRRK20.70221295
84PBK0.69775352
85DAPK20.67732864
86PAK10.67240924
87PRKCZ0.66887676
88MST1R0.65819372
89PDK20.65361822
90STK160.64571544
91MET0.60485843
92PKN20.58402533
93MAPKAPK30.57450221
94MAP2K40.56668198
95RPS6KA10.56278397
96GRK50.55741054
97EGFR0.55688532
98PRKACG0.55576095
99CSNK1G10.55332475
100MAP3K80.55028840
101SMG10.54841073
102MAPKAPK20.51922808
103AKT20.49535665
104PTK20.48306601
105TYK20.47774412
106CAMK1D0.47036995
107SCYL20.45558398
108PIK3CG0.45506234
109ADRBK20.45170170
110CAMK2D0.44799859
111RIPK10.44544475
112IRAK20.43686713
113CSNK1G30.41625396
114LYN0.39112305
115CDK11A0.38691728
116KDR0.38480533
117MAP3K50.38440968
118DYRK30.38096460
119ERBB20.37713049
120CDK140.37299779
121MAPK30.37148137
122CAMK2B0.35730106
123GRK60.35688729
124IKBKE0.35022775
125CDK40.34685347
126PAK20.34245105
127STK38L0.33123738
128CSNK1A1L0.32522140
129EPHB10.32177479
130HIPK20.31777437
131CHUK0.30456687
132CSNK2A10.30017505
133KIT0.29469860
134CDK150.29389709
135RPS6KB10.28966423
136MAPK10.28567401
137PRPF4B0.28420780
138MAP2K30.28159294
139MARK30.27994286
140MAP3K30.27923008
141MAPK70.27563607
142MAP2K60.27166763
143CDK180.25766122
144INSR0.25623923
145STK30.25595605
146ABL10.23984693
147PRKD10.23850454
148RAF10.23193867
149EPHA20.23016537
150FGFR20.22954721
151RPS6KA30.20911687
152MAPK120.20861927
153PTK60.20808613
154CAMK2A0.20419094
155MAP3K70.18684211
156CHEK20.18240413
157PRKCD0.16339198
158PDGFRB0.15724307
159CSNK2A20.15040592
160SGK10.14571344

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31736757
2Nitrogen metabolism_Homo sapiens_hsa009103.38981242
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22746215
4Arginine biosynthesis_Homo sapiens_hsa002203.22467017
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14770073
6Other glycan degradation_Homo sapiens_hsa005112.99262105
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58658905
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55137168
9Tryptophan metabolism_Homo sapiens_hsa003802.53798060
10Complement and coagulation cascades_Homo sapiens_hsa046102.53473119
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45304504
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39262474
13Fatty acid degradation_Homo sapiens_hsa000712.31226876
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30665105
15Renin-angiotensin system_Homo sapiens_hsa046142.30324384
16Fatty acid metabolism_Homo sapiens_hsa012122.19948701
17Fatty acid biosynthesis_Homo sapiens_hsa000612.08438446
18Peroxisome_Homo sapiens_hsa041461.95480779
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94433889
20Butanoate metabolism_Homo sapiens_hsa006501.92665847
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92043299
22Propanoate metabolism_Homo sapiens_hsa006401.91785531
23PPAR signaling pathway_Homo sapiens_hsa033201.85591221
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79072053
25Chemical carcinogenesis_Homo sapiens_hsa052041.77806527
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76001982
27Histidine metabolism_Homo sapiens_hsa003401.73108188
28Caffeine metabolism_Homo sapiens_hsa002321.72108222
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.67191682
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64226937
31beta-Alanine metabolism_Homo sapiens_hsa004101.62704818
32Staphylococcus aureus infection_Homo sapiens_hsa051501.62429391
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.61947297
34Biosynthesis of amino acids_Homo sapiens_hsa012301.55986402
35Folate biosynthesis_Homo sapiens_hsa007901.51884824
36Retinol metabolism_Homo sapiens_hsa008301.51178590
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50042102
38Arginine and proline metabolism_Homo sapiens_hsa003301.49244972
39Selenocompound metabolism_Homo sapiens_hsa004501.48871554
40Mineral absorption_Homo sapiens_hsa049781.48048252
41Phenylalanine metabolism_Homo sapiens_hsa003601.45074333
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42332344
43Fatty acid elongation_Homo sapiens_hsa000621.42026445
44Protein digestion and absorption_Homo sapiens_hsa049741.39655887
45Sulfur relay system_Homo sapiens_hsa041221.37018006
46Pyruvate metabolism_Homo sapiens_hsa006201.34534667
47Bile secretion_Homo sapiens_hsa049761.32768995
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31530054
49Steroid biosynthesis_Homo sapiens_hsa001001.29790073
50Tyrosine metabolism_Homo sapiens_hsa003501.29654242
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.28767063
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28620545
53Starch and sucrose metabolism_Homo sapiens_hsa005001.21455368
54ABC transporters_Homo sapiens_hsa020101.17288873
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17145719
56Oxidative phosphorylation_Homo sapiens_hsa001901.16403254
57Fat digestion and absorption_Homo sapiens_hsa049751.15161940
58Ribosome_Homo sapiens_hsa030101.13110369
59Carbon metabolism_Homo sapiens_hsa012001.09878394
60Sulfur metabolism_Homo sapiens_hsa009201.09645084
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.04614332
62Vitamin B6 metabolism_Homo sapiens_hsa007501.01377037
63Lysine degradation_Homo sapiens_hsa003101.00576616
64Pertussis_Homo sapiens_hsa051330.96509910
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96329338
66Vibrio cholerae infection_Homo sapiens_hsa051100.94155181
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89486087
68Collecting duct acid secretion_Homo sapiens_hsa049660.89309068
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.88676812
70Glutathione metabolism_Homo sapiens_hsa004800.82167758
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81239870
72One carbon pool by folate_Homo sapiens_hsa006700.78615612
73Sphingolipid metabolism_Homo sapiens_hsa006000.76779968
74Glycerolipid metabolism_Homo sapiens_hsa005610.73300694
75Parkinsons disease_Homo sapiens_hsa050120.72438006
76Vitamin digestion and absorption_Homo sapiens_hsa049770.65587468
77Rheumatoid arthritis_Homo sapiens_hsa053230.65423223
78Malaria_Homo sapiens_hsa051440.59853156
79Asthma_Homo sapiens_hsa053100.58035231
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55577332
81Phagosome_Homo sapiens_hsa041450.53253948
82Pentose phosphate pathway_Homo sapiens_hsa000300.49193210
83Alzheimers disease_Homo sapiens_hsa050100.48008754
84Fructose and mannose metabolism_Homo sapiens_hsa000510.47718104
85Metabolic pathways_Homo sapiens_hsa011000.47567910
86Huntingtons disease_Homo sapiens_hsa050160.44282138
87Salmonella infection_Homo sapiens_hsa051320.43115635
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41114040
89Amoebiasis_Homo sapiens_hsa051460.41007722
90Tuberculosis_Homo sapiens_hsa051520.39895366
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36934999
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34339220
93Prion diseases_Homo sapiens_hsa050200.33364465
94Galactose metabolism_Homo sapiens_hsa000520.32271966
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30546572
96Base excision repair_Homo sapiens_hsa034100.28585402
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27577802
98Linoleic acid metabolism_Homo sapiens_hsa005910.27500950
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26503023
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23937739
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23387522
102Osteoclast differentiation_Homo sapiens_hsa043800.23174053
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22031616
104AMPK signaling pathway_Homo sapiens_hsa041520.20507282
105N-Glycan biosynthesis_Homo sapiens_hsa005100.19064100
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18916126
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.18387048
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16431911
109Mismatch repair_Homo sapiens_hsa034300.16355295
110Leishmaniasis_Homo sapiens_hsa051400.16258110
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.14170725
112Circadian rhythm_Homo sapiens_hsa047100.13126587
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11825160
114Insulin resistance_Homo sapiens_hsa049310.11669723
115Bladder cancer_Homo sapiens_hsa052190.09608121
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.07759318
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06245964
118Glucagon signaling pathway_Homo sapiens_hsa049220.03660637
119mTOR signaling pathway_Homo sapiens_hsa041500.03415165
120Insulin signaling pathway_Homo sapiens_hsa049100.01236448
121Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1720463
122Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1667115
123Adherens junction_Homo sapiens_hsa04520-0.1663617
124DNA replication_Homo sapiens_hsa03030-0.1634439
125Lysosome_Homo sapiens_hsa04142-0.1583077
126TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1471318
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1303719
128Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0986563
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0856951
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0752309
131Notch signaling pathway_Homo sapiens_hsa04330-0.0594150

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