HEBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.05153321
2regulation of water loss via skin (GO:0033561)8.43035403
3keratinization (GO:0031424)7.73404371
4intermediate filament organization (GO:0045109)6.79864694
5sphingoid metabolic process (GO:0046519)6.76504216
6keratinocyte proliferation (GO:0043616)6.12055697
7keratinocyte differentiation (GO:0030216)6.07124318
8multicellular organismal water homeostasis (GO:0050891)5.64803497
9sphingosine metabolic process (GO:0006670)5.51610618
10neurofilament cytoskeleton organization (GO:0060052)5.39465800
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.19410531
12regulation of sequestering of triglyceride (GO:0010889)5.15663753
13hemidesmosome assembly (GO:0031581)5.04954278
14diol metabolic process (GO:0034311)5.04050695
15regulation of ruffle assembly (GO:1900027)5.03246162
16glucosamine-containing compound catabolic process (GO:1901072)4.82158476
17long-chain fatty acid biosynthetic process (GO:0042759)4.80316192
18epidermal cell differentiation (GO:0009913)4.78456644
19water homeostasis (GO:0030104)4.76812265
20viral transcription (GO:0019083)4.73419933
21molting cycle (GO:0042303)4.70757478
22hair cycle (GO:0042633)4.70757478
23peptide cross-linking (GO:0018149)4.70256034
24regulation of cell proliferation involved in kidney development (GO:1901722)4.65079833
25intermediate filament cytoskeleton organization (GO:0045104)4.48607982
26translational termination (GO:0006415)4.47454427
27intermediate filament-based process (GO:0045103)4.43155712
28positive regulation of glomerulus development (GO:0090193)4.40077679
29epidermis development (GO:0008544)4.39223617
30regulation of phospholipase A2 activity (GO:0032429)4.26270445
31positive regulation of interleukin-8 secretion (GO:2000484)4.19981739
32membrane budding (GO:0006900)4.00371844
33low-density lipoprotein particle clearance (GO:0034383)3.95084764
34regulation of transforming growth factor beta1 production (GO:0032908)3.91163311
35skin morphogenesis (GO:0043589)3.89021063
36fatty acid elongation (GO:0030497)3.80684928
37interferon-gamma secretion (GO:0072643)3.77205227
38translational elongation (GO:0006414)3.76790853
39viral life cycle (GO:0019058)3.74425257
40regulation of chemokine secretion (GO:0090196)3.72389444
41ectoderm development (GO:0007398)3.68007544
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67568442
43ethanol oxidation (GO:0006069)3.67359210
44ribosomal small subunit biogenesis (GO:0042274)3.65166552
45protein targeting to ER (GO:0045047)3.63056888
46cellular protein complex disassembly (GO:0043624)3.61765122
47cotranslational protein targeting to membrane (GO:0006613)3.61147837
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.55952410
49ethanol metabolic process (GO:0006067)3.53045496
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51577508
51cyclooxygenase pathway (GO:0019371)3.50643936
52regulation of interleukin-8 secretion (GO:2000482)3.48877460
53keratinocyte development (GO:0003334)3.45550780
54G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.43242613
55protein localization to endoplasmic reticulum (GO:0070972)3.42331368
56regulation of glomerulus development (GO:0090192)3.39754280
57cardiac right ventricle morphogenesis (GO:0003215)3.38265808
58negative regulation of erythrocyte differentiation (GO:0045647)3.35264856
59brown fat cell differentiation (GO:0050873)3.35147471
60white fat cell differentiation (GO:0050872)3.33436342
61triglyceride catabolic process (GO:0019433)3.31847087
62positive regulation of chemokine secretion (GO:0090197)3.31447707
63carnitine shuttle (GO:0006853)3.29503809
64positive regulation of vesicle fusion (GO:0031340)3.28873481
65eyelid development in camera-type eye (GO:0061029)3.25702079
66positive regulation of fatty acid oxidation (GO:0046321)3.25316182
67phospholipid scrambling (GO:0017121)3.25179675
68primary alcohol catabolic process (GO:0034310)3.24808776
69atrioventricular valve morphogenesis (GO:0003181)3.24305170
70planar cell polarity pathway involved in neural tube closure (GO:0090179)3.24054064
71fatty acid transmembrane transport (GO:1902001)3.16722079
72hypotonic response (GO:0006971)3.14110400
73plasma membrane repair (GO:0001778)3.13593602
74neural crest cell development (GO:0014032)3.09999767
75negative regulation of kidney development (GO:0090185)3.09526422
76lipoxygenase pathway (GO:0019372)3.07485730
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06646766
78carnitine transmembrane transport (GO:1902603)3.01743657
79primary alcohol metabolic process (GO:0034308)3.01514322
80regulation of fatty acid beta-oxidation (GO:0031998)3.00054897
81diacylglycerol metabolic process (GO:0046339)2.99205364
82valine metabolic process (GO:0006573)2.98894144
83positive regulation of hair follicle development (GO:0051798)2.98846967
84positive regulation of hair cycle (GO:0042635)2.98846967
85cellular response to interferon-alpha (GO:0035457)2.96597853
86long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.95465927
87establishment of tissue polarity (GO:0007164)2.92929009
88establishment of planar polarity (GO:0001736)2.92929009
89prostanoid biosynthetic process (GO:0046457)2.91789597
90prostaglandin biosynthetic process (GO:0001516)2.91789597
91protein complex disassembly (GO:0043241)2.91784401
92regulation of triglyceride catabolic process (GO:0010896)2.91139513
93negative regulation of homotypic cell-cell adhesion (GO:0034111)2.91000002
94translational initiation (GO:0006413)2.89725930
95positive regulation of actin filament depolymerization (GO:0030836)2.89322791
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.88810498
97detection of bacterium (GO:0016045)2.88705656
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88564028
99positive regulation of lipid catabolic process (GO:0050996)2.87604995
100regulation of fatty acid oxidation (GO:0046320)2.86393342
101negative regulation of interferon-gamma production (GO:0032689)2.86369246
102limb bud formation (GO:0060174)2.85449591
103protein targeting to membrane (GO:0006612)2.83406139
104axonemal dynein complex assembly (GO:0070286)2.81967135
105retinol metabolic process (GO:0042572)2.79850985
106negative regulation of dendrite morphogenesis (GO:0050774)2.79679668
107uterus development (GO:0060065)2.79276141
108macromolecular complex disassembly (GO:0032984)2.78366359
109sympathetic nervous system development (GO:0048485)2.78101716
110fatty acid homeostasis (GO:0055089)2.77374660
111regulation of glomerular filtration (GO:0003093)2.77111747
112gland morphogenesis (GO:0022612)2.76739395
113amino-acid betaine transport (GO:0015838)2.76524713
114carnitine transport (GO:0015879)2.76524713
115heart valve morphogenesis (GO:0003179)2.74810394
116regulation of hair follicle development (GO:0051797)2.74756734
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74583984
118calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74271742
119regulation of necroptotic process (GO:0060544)2.74194760
120neutral lipid catabolic process (GO:0046461)2.73093122
121acylglycerol catabolic process (GO:0046464)2.73093122
122NADH metabolic process (GO:0006734)2.70635069
123positive regulation of epidermis development (GO:0045684)2.68807015
124negative regulation of fatty acid transport (GO:2000192)2.68691359
125cilium or flagellum-dependent cell motility (GO:0001539)2.67387022
126regulation of axon regeneration (GO:0048679)2.66874022
127regulation of neuron projection regeneration (GO:0070570)2.66874022
128cardiolipin metabolic process (GO:0032048)2.66869661
129negative regulation of granulocyte differentiation (GO:0030853)2.66611812
130positive regulation of fatty acid metabolic process (GO:0045923)2.64835647
131detection of other organism (GO:0098543)2.64752047
132ribosomal small subunit assembly (GO:0000028)2.64000076
133ribosomal large subunit biogenesis (GO:0042273)2.59606903
134fatty acid beta-oxidation (GO:0006635)2.57579385
135positive regulation by symbiont of host defense response (GO:0052509)2.57195371
136modulation by symbiont of host defense response (GO:0052031)2.57195371
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57195371
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57195371
139positive regulation by organism of defense response of other organism involved in symbiotic interact2.57195371
140modulation by symbiont of host immune response (GO:0052553)2.57195371
141maturation of SSU-rRNA (GO:0030490)2.57066386
142negative regulation of keratinocyte proliferation (GO:0010839)2.55067768
143negative regulation of cell fate specification (GO:0009996)2.54964455
144pyrimidine nucleotide catabolic process (GO:0006244)2.54742643
145epithelial cell-cell adhesion (GO:0090136)2.51112013
146CDP-diacylglycerol metabolic process (GO:0046341)2.50364119
147response to peptidoglycan (GO:0032494)2.46916305
148fatty acid oxidation (GO:0019395)2.40458885
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.38021806
150biotin metabolic process (GO:0006768)2.36194015
151oxaloacetate metabolic process (GO:0006107)2.35734165
152* regulation of necrotic cell death (GO:0010939)2.33949605
153lipid storage (GO:0019915)2.33833490
154lipid oxidation (GO:0034440)2.32404060
155creatine metabolic process (GO:0006600)2.31789000
156alpha-linolenic acid metabolic process (GO:0036109)2.31326081
157fatty acid catabolic process (GO:0009062)2.30223901
158detection of external biotic stimulus (GO:0098581)2.26508796
159reactive oxygen species biosynthetic process (GO:1903409)2.26136335
160detection of molecule of bacterial origin (GO:0032490)2.24535693
161lymph vessel development (GO:0001945)2.24494979
162hydrogen peroxide biosynthetic process (GO:0050665)2.24377249
163galactose catabolic process (GO:0019388)2.22825605
164mature B cell differentiation involved in immune response (GO:0002313)2.21971312
165leukocyte aggregation (GO:0070486)2.21029091
166pyrimidine-containing compound transmembrane transport (GO:0072531)2.19820460
167tooth mineralization (GO:0034505)2.19570710
168calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.17637508
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.17014242
170positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.13710380
171desmosome organization (GO:0002934)12.7753327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.74807612
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.42410356
3VDR_21846776_ChIP-Seq_THP-1_Human2.94853981
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.70721437
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65577956
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.65490591
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.64441007
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.47536359
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.40890099
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40877080
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40752462
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.35892531
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.29785457
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21438349
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20580461
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.17444980
17VDR_24763502_ChIP-Seq_THP-1_Human2.12197017
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06607040
19ZNF263_19887448_ChIP-Seq_K562_Human2.05716832
20LXR_22292898_ChIP-Seq_THP-1_Human2.05264821
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.00112725
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.00112725
23TP63_17297297_ChIP-ChIP_HaCaT_Human14.4313233
24SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84191962
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84000518
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.83484736
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77505460
28CJUN_26792858_Chip-Seq_BT549_Human1.77499394
29SOX2_20726797_ChIP-Seq_SW620_Human1.73592112
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69402699
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66467742
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65965694
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63592926
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62463951
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.62274153
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59663106
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.57061916
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54421321
39* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53685121
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51892896
41TCF7_22412390_ChIP-Seq_EML_Mouse1.47388442
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43783261
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.43370465
44KDM2B_26808549_Chip-Seq_DND41_Human1.42621487
45* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41860050
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41395783
47CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40976650
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.40530469
49TP53_18474530_ChIP-ChIP_U2OS_Human1.40043472
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39270328
51P68_20966046_ChIP-Seq_HELA_Human1.38739777
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.37704370
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.34745037
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32918057
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30227191
56* TP63_23658742_ChIP-Seq_EP156T_Human1.29981706
57AR_21572438_ChIP-Seq_LNCaP_Human1.26837676
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26344171
59MAF_26560356_Chip-Seq_TH2_Human1.25975986
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.25881417
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.24816056
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24655334
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23364535
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21588277
65BCOR_27268052_Chip-Seq_Bcells_Human1.20556989
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20333834
67CREB1_26743006_Chip-Seq_LNCaP_Human1.20193686
68STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20024233
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20006254
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19787899
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19787899
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.19748738
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19193131
74ATF3_27146783_Chip-Seq_COLON_Human1.17971555
75KLF5_25053715_ChIP-Seq_YYC3_Human1.17963823
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16055637
77BCAT_22108803_ChIP-Seq_LS180_Human1.15594123
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15177882
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.15119987
80STAT1_20625510_ChIP-Seq_HELA_Human1.15042577
81BCL6_27268052_Chip-Seq_Bcells_Human1.15017870
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14372457
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14196527
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13562537
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13017815
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12092103
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11163912
88MAF_26560356_Chip-Seq_TH1_Human1.11144010
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10996538
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09565977
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08491828
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08100850
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07809860
94SCL_19346495_ChIP-Seq_HPC-7_Human1.07584126
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07445071
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07426046
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06286571
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.06067189
99GATA3_24758297_ChIP-Seq_MCF-7_Human1.05980521
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.05807462
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05308081
102MYC_22102868_ChIP-Seq_BL_Human1.04100703
103* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03486006
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03252750
105CHD1_26751641_Chip-Seq_LNCaP_Human1.02091718
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.01695678
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.00834672
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00805210
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00453498
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00183714
111TBX20_22328084_ChIP-Seq_HEART_Mouse1.00004075
112TBX20_22080862_ChIP-Seq_HEART_Mouse1.00004075
113AHR_22903824_ChIP-Seq_MCF-7_Human0.99871320
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99604372
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99327295
116SA1_27219007_Chip-Seq_Bcells_Human0.99184169
117SMC4_20622854_ChIP-Seq_HELA_Human0.99077724
118CTCF_21964334_Chip-Seq_Bcells_Human0.97764146
119TP63_22573176_ChIP-Seq_HFKS_Human0.95456423
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95129231
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94980913
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94686299
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94202592
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.93980624
125UTX_26944678_Chip-Seq_JUKART_Human0.93942929
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93741562
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93405485
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93149957
129RNF2_27304074_Chip-Seq_ESCs_Mouse0.92229895
130RACK7_27058665_Chip-Seq_MCF-7_Human0.91662273
131* EZH2_27294783_Chip-Seq_ESCs_Mouse0.88195062
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88158453
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87921279
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87921279
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.87183655
136* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86937719
137TCF4_22108803_ChIP-Seq_LS180_Human0.86777198
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86183204
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85545175
140* UBF1/2_26484160_Chip-Seq_HMECs_Human0.84788322
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.83834078
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83690405
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81426770
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80872013
145CLOCK_20551151_ChIP-Seq_293T_Human0.80756069
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80520755
147RXR_22108803_ChIP-Seq_LS180_Human0.79013466
148CTCF_27219007_Chip-Seq_Bcells_Human0.76720568
149GATA4_25053715_ChIP-Seq_YYC3_Human0.76591798
150PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.75631716
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.74349746
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73999474
153TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72972895
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72274978
155EGR1_19032775_ChIP-ChIP_M12_Human0.70728000
156GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70546371
157BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69673758
158GATA6_25053715_ChIP-Seq_YYC3_Human0.69525153
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66921965
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.65796912
161FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65424759
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64867257
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.63270702
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.61826887
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.61673547
166CSB_26484114_Chip-Seq_FIBROBLAST_Human0.61025110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.18585758
2MP0005275_abnormal_skin_tensile5.82564898
3MP0010234_abnormal_vibrissa_follicle5.62982538
4MP0003941_abnormal_skin_development5.06363153
5MP0005501_abnormal_skin_physiology4.38580049
6MP0004381_abnormal_hair_follicle4.07375543
7MP0005670_abnormal_white_adipose4.04590629
8MP0004130_abnormal_muscle_cell3.43185557
9MP0005666_abnormal_adipose_tissue3.39273011
10MP0002060_abnormal_skin_morphology3.15616420
11MP0010771_integument_phenotype2.90976745
12MP0001216_abnormal_epidermal_layer2.88362835
13MP0000579_abnormal_nail_morphology2.65905706
14MP0009379_abnormal_foot_pigmentation2.55508036
15MP0002098_abnormal_vibrissa_morphology2.52255426
16MP0005375_adipose_tissue_phenotype2.52153815
17MP0002132_abnormal_respiratory_system2.47705280
18MP0010678_abnormal_skin_adnexa2.47095947
19MP0003453_abnormal_keratinocyte_physiol2.46529765
20MP0002009_preneoplasia2.39009205
21MP0000383_abnormal_hair_follicle2.31459237
22MP0002971_abnormal_brown_adipose2.28207758
23MP0003724_increased_susceptibility_to2.26970060
24MP0005451_abnormal_body_composition2.22530489
25MP0002254_reproductive_system_inflammat2.14084553
26MP0000647_abnormal_sebaceous_gland2.12882033
27MP0003705_abnormal_hypodermis_morpholog2.12206368
28MP0003828_pulmonary_edema2.12149453
29MP0003566_abnormal_cell_adhesion2.06816367
30MP0000762_abnormal_tongue_morphology2.03301120
31MP0000377_abnormal_hair_follicle1.98967621
32MP0000427_abnormal_hair_cycle1.96266391
33MP0000566_synostosis1.95708799
34MP0003191_abnormal_cellular_cholesterol1.94887277
35MP0001346_abnormal_lacrimal_gland1.88494938
36MP0000467_abnormal_esophagus_morphology1.78149400
37MP0004947_skin_inflammation1.76274656
38MP0010030_abnormal_orbit_morphology1.73234802
39MP0003646_muscle_fatigue1.70314477
40MP0003868_abnormal_feces_composition1.56756309
41MP0005334_abnormal_fat_pad1.51842727
42MP0000678_abnormal_parathyroid_gland1.49793926
43MP0004858_abnormal_nervous_system1.46550141
44MP0008438_abnormal_cutaneous_collagen1.45021940
45MP0003186_abnormal_redox_activity1.44506282
46MP0006036_abnormal_mitochondrial_physio1.41910237
47MP0009384_cardiac_valve_regurgitation1.40929181
48MP0009115_abnormal_fat_cell1.37537040
49MP0002876_abnormal_thyroid_physiology1.36753058
50MP0003303_peritoneal_inflammation1.34500299
51MP0009931_abnormal_skin_appearance1.33471514
52MP0001243_abnormal_dermal_layer1.32737830
53MP0000003_abnormal_adipose_tissue1.32597842
54MP0010329_abnormal_lipoprotein_level1.31958626
55MP0003136_yellow_coat_color1.29439986
56MP0001191_abnormal_skin_condition1.23906998
57MP0001340_abnormal_eyelid_morphology1.22089350
58MP0006138_congestive_heart_failure1.21607958
59MP0002970_abnormal_white_adipose1.21128862
60MP0005503_abnormal_tendon_morphology1.20731521
61MP0009250_abnormal_appendicular_skeleto1.19329048
62MP0004145_abnormal_muscle_electrophysio1.17761465
63MP0005409_darkened_coat_color1.17165070
64MP0002282_abnormal_trachea_morphology1.16969472
65MP0002118_abnormal_lipid_homeostasis1.16655171
66MP0000858_altered_metastatic_potential1.16400469
67MP0003436_decreased_susceptibility_to1.16350004
68MP0000372_irregular_coat_pigmentation1.16031560
69MP0005508_abnormal_skeleton_morphology1.15622982
70MP0010352_gastrointestinal_tract_polyps1.14512671
71MP0000750_abnormal_muscle_regeneration1.14416313
72MP0005360_urolithiasis1.12228663
73MP0008260_abnormal_autophagy1.12027829
74MP0000516_abnormal_urinary_system1.11393037
75MP0005367_renal/urinary_system_phenotyp1.11393037
76MP0003866_abnormal_defecation1.11072668
77MP0002735_abnormal_chemical_nociception1.09727580
78MP0005023_abnormal_wound_healing1.09411281
79MP0009053_abnormal_anal_canal1.07546689
80MP0005623_abnormal_meninges_morphology1.06633387
81MP0001299_abnormal_eye_distance/1.05921875
82MP0000367_abnormal_coat/_hair1.01836772
83MP0000465_gastrointestinal_hemorrhage1.01412091
84MP0001542_abnormal_bone_strength1.00678132
85MP0005164_abnormal_response_to1.00329949
86MP0005397_hematopoietic_system_phenotyp0.99231830
87MP0001545_abnormal_hematopoietic_system0.99231830
88MP0008004_abnormal_stomach_pH0.98918581
89MP0001881_abnormal_mammary_gland0.98052200
90MP0001873_stomach_inflammation0.97903827
91MP0004264_abnormal_extraembryonic_tissu0.97818184
92MP0002751_abnormal_autonomic_nervous0.96809424
93MP0004185_abnormal_adipocyte_glucose0.96518592
94MP0000538_abnormal_urinary_bladder0.94308444
95MP0005535_abnormal_body_temperature0.93627244
96MP0004087_abnormal_muscle_fiber0.91239124
97MP0009643_abnormal_urine_homeostasis0.89978766
98MP0005319_abnormal_enzyme/_coenzyme0.87526574
99MP0002160_abnormal_reproductive_system0.87314456
100MP0000759_abnormal_skeletal_muscle0.87225264
101MP0004043_abnormal_pH_regulation0.86094316
102MP0000537_abnormal_urethra_morphology0.86048708
103MP0002736_abnormal_nociception_after0.85761480
104MP0002139_abnormal_hepatobiliary_system0.84773201
105MP0004272_abnormal_basement_membrane0.84565789
106MP0005365_abnormal_bile_salt0.83446849
107MP0001661_extended_life_span0.83434526
108MP0000609_abnormal_liver_physiology0.83333685
109MP0003755_abnormal_palate_morphology0.83331369
110MP0005085_abnormal_gallbladder_physiolo0.83135526
111MP0003959_abnormal_lean_body0.83132049
112MP0010155_abnormal_intestine_physiology0.83000065
113MP0003011_delayed_dark_adaptation0.82295283
114MP0001968_abnormal_touch/_nociception0.81852530
115MP0005083_abnormal_biliary_tract0.81248745
116MP0003315_abnormal_perineum_morphology0.81048973
117MP0004484_altered_response_of0.80886908
118MP0002177_abnormal_outer_ear0.80725724
119MP0010386_abnormal_urinary_bladder0.80009845
120MP0004036_abnormal_muscle_relaxation0.79975407
121MP0005647_abnormal_sex_gland0.79808293
122MP0004019_abnormal_vitamin_homeostasis0.78757411
123MP0003806_abnormal_nucleotide_metabolis0.78467094
124MP0005330_cardiomyopathy0.78082152
125MP0004782_abnormal_surfactant_physiolog0.77926853
126MP0005025_abnormal_response_to0.77786590
127MP0010630_abnormal_cardiac_muscle0.77551262
128MP0002166_altered_tumor_susceptibility0.76858244
129MP0005076_abnormal_cell_differentiation0.76341729
130MP0001663_abnormal_digestive_system0.76230859
131MP0002419_abnormal_innate_immunity0.76174201
132MP0003942_abnormal_urinary_system0.76085608
133MP0001851_eye_inflammation0.75357226
134MP0002396_abnormal_hematopoietic_system0.74866280
135MP0005448_abnormal_energy_balance0.74787514
136MP0002078_abnormal_glucose_homeostasis0.74231595
137MP0001984_abnormal_olfaction0.73979523
138MP0000681_abnormal_thyroid_gland0.73053158
139MP0001664_abnormal_digestion0.72961352
140MP0001533_abnormal_skeleton_physiology0.72616109
141MP0000470_abnormal_stomach_morphology0.71873540
142MP0005636_abnormal_mineral_homeostasis0.71714883
143MP0002163_abnormal_gland_morphology0.71680961
144MP0000627_abnormal_mammary_gland0.71251251
145MP0003385_abnormal_body_wall0.71172639
146MP0001666_abnormal_nutrient_absorption0.70867847
147MP0005385_cardiovascular_system_phenoty0.70702943
148MP0001544_abnormal_cardiovascular_syste0.70702943
149MP0002233_abnormal_nose_morphology0.68770333
150MP0005390_skeleton_phenotype0.63804853
151MP0002249_abnormal_larynx_morphology0.63295830
152MP0000163_abnormal_cartilage_morphology0.62971357
153MP0002295_abnormal_pulmonary_circulatio0.62842161
154MP0006276_abnormal_autonomic_nervous0.60427655
155MP0002896_abnormal_bone_mineralization0.55793321
156MP0001270_distended_abdomen0.54529294
157MP0002111_abnormal_tail_morphology0.53647964
158MP0000049_abnormal_middle_ear0.53454698
159MP0002184_abnormal_innervation0.50530001
160MP0002109_abnormal_limb_morphology0.49497540
161MP0002277_abnormal_respiratory_mucosa0.48327453
162MP0002877_abnormal_melanocyte_morpholog0.48205252
163MP0002115_abnormal_skeleton_extremities0.47394178
164MP0005248_abnormal_Harderian_gland0.46973100
165MP0002733_abnormal_thermal_nociception0.44793893
166MP0002090_abnormal_vision0.44113566
167MP0001784_abnormal_fluid_regulation0.43267187
168MP0002697_abnormal_eye_size0.42337290
169MP0003279_aneurysm0.41589715
170MP0001849_ear_inflammation0.41124552
171MP0001348_abnormal_lacrimal_gland0.40353452
172MP0000534_abnormal_ureter_morphology0.40175733
173MP0003938_abnormal_ear_development0.40125988
174MP0002006_tumorigenesis0.38697361
175MP0004270_analgesia0.38094104
176MP0000613_abnormal_salivary_gland0.38053164
177MP0001919_abnormal_reproductive_system0.36144045
178MP0000432_abnormal_head_morphology0.35776318

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.42091986
2Congenital ichthyosiform erythroderma (HP:0007431)6.04414700
3Hypotrichosis (HP:0001006)5.71622997
4Right ventricular cardiomyopathy (HP:0011663)5.37919139
5Lip pit (HP:0100267)5.08794167
6Woolly hair (HP:0002224)4.98720754
7Ulnar claw (HP:0001178)4.78708296
8Parakeratosis (HP:0001036)4.75549793
9Increased IgE level (HP:0003212)4.45837355
10Plantar hyperkeratosis (HP:0007556)4.37833803
11Palmoplantar hyperkeratosis (HP:0000972)4.34904439
12Abnormality of nail color (HP:0100643)4.23812569
13Distal lower limb muscle weakness (HP:0009053)4.22659663
14Erythema (HP:0010783)4.20322851
15Fragile nails (HP:0001808)4.05970900
16Palmar hyperkeratosis (HP:0010765)4.00917168
17Natal tooth (HP:0000695)3.76435687
18Hyporeflexia of lower limbs (HP:0002600)3.66901046
19Onycholysis (HP:0001806)3.65351480
20Eczematoid dermatitis (HP:0000976)3.52491331
21Popliteal pterygium (HP:0009756)3.44743175
22Erythroderma (HP:0001019)3.40344155
23Conjunctival hamartoma (HP:0100780)3.33275101
24Concave nail (HP:0001598)3.17879068
25Curly hair (HP:0002212)3.15013606
26Sparse scalp hair (HP:0002209)3.09798888
27Advanced eruption of teeth (HP:0006288)3.09615278
28Corneal erosion (HP:0200020)3.06404194
29Hypohidrosis (HP:0000966)2.98710137
30Hypertriglyceridemia (HP:0002155)2.93013935
31Exercise-induced myalgia (HP:0003738)2.92334236
32Sparse eyelashes (HP:0000653)2.87816117
33Abnormal hemoglobin (HP:0011902)2.87403536
34Abnormality of the axillary hair (HP:0100134)2.85377950
35Abnormality of secondary sexual hair (HP:0009888)2.85377950
36Down-sloping shoulders (HP:0200021)2.84986458
37Increased muscle lipid content (HP:0009058)2.84464543
38Nail dystrophy (HP:0008404)2.82821093
39Areflexia of lower limbs (HP:0002522)2.77408987
40Abnormal respiratory motile cilium morphology (HP:0005938)2.76093783
41Abnormal respiratory epithelium morphology (HP:0012253)2.76093783
42Rhabdomyolysis (HP:0003201)2.71782114
43Abnormal blistering of the skin (HP:0008066)2.70649405
44Acanthosis nigricans (HP:0000956)2.66536958
45Pili torti (HP:0003777)2.66116527
46Premature rupture of membranes (HP:0001788)2.66027678
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59432957
48Rectal prolapse (HP:0002035)2.55546633
49Increased variability in muscle fiber diameter (HP:0003557)2.53731560
50Ventricular tachycardia (HP:0004756)2.49582103
51Recurrent bacterial skin infections (HP:0005406)2.47211542
52Palmoplantar keratoderma (HP:0000982)2.45357629
53Anhidrosis (HP:0000970)2.44733603
54Atrophic scars (HP:0001075)2.44183525
55Abnormality of skeletal muscle fiber size (HP:0012084)2.42613508
56Type 1 muscle fiber predominance (HP:0003803)2.41565562
57Protrusio acetabuli (HP:0003179)2.40587408
58Elevated erythrocyte sedimentation rate (HP:0003565)2.40234668
59Severe Myopia (HP:0011003)2.36884929
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33062432
61Steppage gait (HP:0003376)2.32807752
62Fasciculations (HP:0002380)2.30634182
63Pterygium (HP:0001059)2.29437431
64Myositis (HP:0100614)2.29374642
65Gastrointestinal infarctions (HP:0005244)2.29369549
66Aplasia involving bones of the extremities (HP:0009825)2.28339114
67Aplasia involving bones of the upper limbs (HP:0009823)2.28339114
68Aplasia of the phalanges of the hand (HP:0009802)2.28339114
69Recurrent abscess formation (HP:0002722)2.28250028
70Muscle fiber splitting (HP:0003555)2.26467638
71Ventricular fibrillation (HP:0001663)2.25904182
72Milia (HP:0001056)2.23969077
73Oligomenorrhea (HP:0000876)2.21912030
74Renal tubular acidosis (HP:0001947)2.19460924
75Chronic otitis media (HP:0000389)2.19390045
76Hoarse voice (HP:0001609)2.19229050
77Difficulty running (HP:0009046)2.18152100
78Muscle fiber inclusion bodies (HP:0100299)2.17109842
79Chronic sinusitis (HP:0011109)2.14565934
80Myopathic facies (HP:0002058)2.14313073
81Pruritus (HP:0000989)2.13832031
82Fragile skin (HP:0001030)2.13235774
83Upper limb muscle weakness (HP:0003484)2.12943549
84Recurrent gram-negative bacterial infections (HP:0005420)2.12586656
85Ectropion (HP:0000656)2.11407435
86Foot dorsiflexor weakness (HP:0009027)2.10192639
87Corneal dystrophy (HP:0001131)2.10086723
88Abnormality of cells of the erythroid lineage (HP:0012130)2.08216526
89Chronic bronchitis (HP:0004469)2.08105975
90Abnormality of the salivary glands (HP:0010286)2.07920779
91Muscle stiffness (HP:0003552)2.07055806
92Hyperthyroidism (HP:0000836)2.06608790
93Gingivitis (HP:0000230)2.06011731
94Pallor (HP:0000980)2.05296874
95Vertebral compression fractures (HP:0002953)2.03395155
96Abnormality of the distal phalanges of the toes (HP:0010182)2.02983534
97Bulbar palsy (HP:0001283)2.02908657
98Brittle hair (HP:0002299)2.02647181
99Achilles tendon contracture (HP:0001771)2.02526330
100Hypoplastic labia majora (HP:0000059)2.01569604
101Abnormality of the 2nd finger (HP:0004100)1.99078340
102Abnormal respiratory motile cilium physiology (HP:0012261)1.98711998
103Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98426342
104Nemaline bodies (HP:0003798)1.98107359
105Nasal polyposis (HP:0100582)1.97317241
106Neonatal hypoglycemia (HP:0001998)1.96558863
107Congenital, generalized hypertrichosis (HP:0004540)1.95331918
108Alopecia of scalp (HP:0002293)1.95275356
109Flat acetabular roof (HP:0003180)1.95253320
110Distal arthrogryposis (HP:0005684)1.95229575
111Increased connective tissue (HP:0009025)1.92267281
112Fatigue (HP:0012378)1.91377369
113Abnormality of the nasal mucosa (HP:0000433)1.91037957
114Gangrene (HP:0100758)1.90679898
115Myoglobinuria (HP:0002913)1.89525353
116Lack of skin elasticity (HP:0100679)1.89136292
117Pigmentary retinal degeneration (HP:0001146)1.88996548
118Atelectasis (HP:0100750)1.88737641
119Chronic obstructive pulmonary disease (HP:0006510)1.88121624
120Obstructive lung disease (HP:0006536)1.88121624
121Abnormality of the foot musculature (HP:0001436)1.87642440
122Increased intramyocellular lipid droplets (HP:0012240)1.86705332
123Abnormality of the labia majora (HP:0012881)1.85240820
124Orchitis (HP:0100796)1.85188131
125Radial bowing (HP:0002986)1.84633120
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84627497
127Nasolacrimal duct obstruction (HP:0000579)1.84311181
128Stenosis of the external auditory canal (HP:0000402)1.84048842
129Ileus (HP:0002595)1.83746017
130Hypercortisolism (HP:0001578)1.82349203
131Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79420517
132Seborrheic dermatitis (HP:0001051)1.78860880
133Thick nail (HP:0001805)1.78736367
134Dry skin (HP:0000958)1.78157795
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.77560278
136Malnutrition (HP:0004395)1.76757506
137Increased serum ferritin (HP:0003281)1.76223410
138Abnormality of the Achilles tendon (HP:0005109)1.75223669
139Amyloidosis (HP:0011034)1.73997301
140Prolonged bleeding time (HP:0003010)1.73970612
141Hyperlipoproteinemia (HP:0010980)1.72986448
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.72825734
143Absent/shortened dynein arms (HP:0200106)1.72825734
144Renal tubular dysfunction (HP:0000124)1.71831481
145Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71399190
146Vascular calcification (HP:0004934)1.71188122
147Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70825965
148Insulin-resistant diabetes mellitus (HP:0000831)1.70518568
149Abnormality of the phalanges of the hallux (HP:0010057)1.68097506
150Asymmetric septal hypertrophy (HP:0001670)1.67613036
151Bradycardia (HP:0001662)1.67429039
152Abnormal ciliary motility (HP:0012262)1.67353175
153Thoracolumbar scoliosis (HP:0002944)1.67238995
154Ulnar deviation of the wrist (HP:0003049)1.67209832
155Hypodontia (HP:0000668)1.66345028
156Hemorrhage of the eye (HP:0011885)1.66034522
157Metaphyseal dysplasia (HP:0100255)1.65727173
158Testicular atrophy (HP:0000029)1.65528176
159Absent phalangeal crease (HP:0006109)1.65468171
160Polygenic inheritance (HP:0010982)1.65155094
161Peritonitis (HP:0002586)1.64945670
162Neonatal short-limb short stature (HP:0008921)1.62217448
163Short nail (HP:0001799)1.61883014
164Spinal rigidity (HP:0003306)1.61260583
165Colitis (HP:0002583)1.59351365
166Acute hepatic failure (HP:0006554)1.59217104
167Soft skin (HP:0000977)1.58869628
168Hyperactive renin-angiotensin system (HP:0000841)1.58626201
169Hyperkalemia (HP:0002153)1.58461773
170Overgrowth (HP:0001548)1.58016792
171Rhinitis (HP:0012384)1.57875832
172Hypoparathyroidism (HP:0000829)1.57379375
173Septate vagina (HP:0001153)1.57082110
174Cutaneous finger syndactyly (HP:0010554)1.55613626
175Abnormality of the lacrimal duct (HP:0011481)1.55457623
176Macrocytic anemia (HP:0001972)1.54508551
177Hypothermia (HP:0002045)1.54490972
178Oligodontia (HP:0000677)1.54306463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.68659588
2MST43.99701683
3LIMK13.38412460
4FER3.37732530
5TESK13.16140818
6MAP3K33.13685104
7PIM23.03415208
8LATS22.91590512
9RIPK12.91367370
10MST1R2.80543660
11RIPK42.45943183
12RPS6KB22.38477602
13EPHB22.19043561
14BCKDK2.17516219
15SIK12.14056775
16MAP3K22.12665220
17TRPM72.08220591
18BCR1.96552719
19MINK11.81528893
20MAP3K91.78865928
21STK161.77146017
22IRAK41.66849323
23LMTK21.65790435
24NEK91.62259289
25EPHB11.62227563
26MAPKAPK51.61370788
27NME21.60890508
28LRRK21.55657180
29EPHA31.54447247
30MAP3K111.52665408
31MAP3K131.52339422
32TYK21.52043869
33DDR21.48620053
34MAP4K11.47324448
35GRK61.44667582
36STK241.43637119
37BMPR1B1.41020462
38DMPK1.40830267
39BLK1.40237787
40ERBB31.36982894
41CSK1.31073072
42PRKAA21.25708405
43PDPK11.24974550
44MAP3K61.21423286
45MET1.21150302
46GRK51.17306640
47PKN21.16407456
48LATS11.15407480
49EPHA21.14799892
50NTRK11.14592714
51MAP2K11.13988657
52EEF2K1.10943790
53STK38L1.10820796
54PRKD21.09598143
55MAPK151.06489273
56TAOK11.06260981
57AKT31.05732132
58PIK3CG1.05534366
59ABL21.05077730
60SIK31.04608531
61PIK3CA1.04181003
62IRAK11.03870412
63GRK71.03789049
64MAP3K121.03229505
65ADRBK11.03080934
66ZAP700.99853547
67CASK0.99444476
68PBK0.99316299
69PAK30.98486921
70IRAK30.97392568
71MAPK120.92506287
72MAP2K60.91982670
73WNK10.89605397
74MARK20.88676740
75TBK10.88612356
76JAK30.86056776
77ROCK10.86039358
78MAPKAPK20.84553023
79MOS0.83447755
80TGFBR20.81820713
81FES0.81187574
82HIPK20.80355624
83PTK20.80285332
84MARK30.79215923
85NLK0.77164046
86ICK0.75941032
87TIE10.75642568
88PTK60.75218141
89AURKA0.74742299
90PRPF4B0.74527085
91ERN10.74379421
92MAP3K70.74273826
93STK390.73456311
94IKBKB0.71676349
95RPS6KL10.70399178
96RPS6KC10.70399178
97MAP3K10.70242857
98MTOR0.69009048
99WNK40.67157748
100CAMK1D0.66411945
101CAMK10.64052047
102IKBKE0.62970598
103MAP2K20.62566179
104RPS6KA60.62104515
105DYRK1B0.60032422
106FRK0.59123176
107ILK0.58019481
108MAP2K40.57712134
109BTK0.57052777
110STK100.55418159
111TEC0.54353612
112MAP3K50.53148041
113RET0.52801215
114TGFBR10.52696530
115STK380.52316701
116PDK10.52090232
117IRAK20.51933913
118SGK30.51589347
119TRIB30.50324969
120TTN0.49980916
121SMG10.49066231
122RPS6KA20.48157316
123PRKCE0.47352810
124TLK10.46772377
125JAK20.45624950
126FGFR10.44869178
127GRK10.44734340
128ARAF0.44204186
129STK110.42899661
130PRKD10.42286073
131MAP3K140.41455133
132SCYL20.40858135
133HCK0.40719273
134STK40.40380396
135KSR20.40354441
136CDK60.38901859
137MAP2K30.37170274
138ROCK20.36726768
139CDK140.34987333
140FGFR30.34681068
141BRAF0.34210442
142OBSCN0.32409892
143PHKG20.32275234
144PHKG10.32275234
145MATK0.31482319
146RPS6KA40.31346410
147YES10.30491515
148PRKCI0.30368402
149MYLK0.29945104
150CSNK1E0.29727534
151ERBB40.28771757
152DAPK30.28713444
153SRC0.28532529
154FGFR20.26068459
155CDK190.25642411
156NME10.24866648
157NTRK30.24507860
158ERBB20.22847500
159PDGFRA0.18674495
160TNK20.16521785

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.37903417
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.41251123
3Sphingolipid metabolism_Homo sapiens_hsa006003.37784592
4Sulfur relay system_Homo sapiens_hsa041223.32089674
5Fatty acid degradation_Homo sapiens_hsa000712.74211239
6PPAR signaling pathway_Homo sapiens_hsa033202.50533198
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.28329404
8Arachidonic acid metabolism_Homo sapiens_hsa005902.13884974
9Fatty acid biosynthesis_Homo sapiens_hsa000612.11326315
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.11300347
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.11108490
12Oxidative phosphorylation_Homo sapiens_hsa001902.00841579
13Fatty acid elongation_Homo sapiens_hsa000621.97310915
14Glycerolipid metabolism_Homo sapiens_hsa005611.88282422
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.81322057
16Phenylalanine metabolism_Homo sapiens_hsa003601.78038306
17Acute myeloid leukemia_Homo sapiens_hsa052211.77087850
18Linoleic acid metabolism_Homo sapiens_hsa005911.68496459
19Fatty acid metabolism_Homo sapiens_hsa012121.62416591
20Basal cell carcinoma_Homo sapiens_hsa052171.59230938
21Hippo signaling pathway_Homo sapiens_hsa043901.58713433
22Insulin resistance_Homo sapiens_hsa049311.57799524
23ECM-receptor interaction_Homo sapiens_hsa045121.57397192
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56463230
25Collecting duct acid secretion_Homo sapiens_hsa049661.55870580
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49782050
27Tight junction_Homo sapiens_hsa045301.48407174
28Proteasome_Homo sapiens_hsa030501.47251677
29Bladder cancer_Homo sapiens_hsa052191.42138603
30beta-Alanine metabolism_Homo sapiens_hsa004101.41609686
31AMPK signaling pathway_Homo sapiens_hsa041521.40859554
32Vibrio cholerae infection_Homo sapiens_hsa051101.38350980
33Hedgehog signaling pathway_Homo sapiens_hsa043401.36188435
34Sulfur metabolism_Homo sapiens_hsa009201.34280176
35Parkinsons disease_Homo sapiens_hsa050121.32184188
36Synaptic vesicle cycle_Homo sapiens_hsa047211.27961943
37Alzheimers disease_Homo sapiens_hsa050101.27860470
38Adherens junction_Homo sapiens_hsa045201.27718951
39Thyroid cancer_Homo sapiens_hsa052161.27611656
40Fat digestion and absorption_Homo sapiens_hsa049751.27436630
41Tyrosine metabolism_Homo sapiens_hsa003501.25808166
42Axon guidance_Homo sapiens_hsa043601.25250629
43VEGF signaling pathway_Homo sapiens_hsa043701.24667527
44Sphingolipid signaling pathway_Homo sapiens_hsa040711.24589575
45Melanoma_Homo sapiens_hsa052181.23209344
46Melanogenesis_Homo sapiens_hsa049161.19680184
47Proteoglycans in cancer_Homo sapiens_hsa052051.18363070
48Ether lipid metabolism_Homo sapiens_hsa005651.18289538
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15975824
50TGF-beta signaling pathway_Homo sapiens_hsa043501.15693903
51Phagosome_Homo sapiens_hsa041451.14698736
52Insulin signaling pathway_Homo sapiens_hsa049101.14201390
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12959796
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12568540
55Starch and sucrose metabolism_Homo sapiens_hsa005001.10769605
56Pyruvate metabolism_Homo sapiens_hsa006201.09007385
57Cardiac muscle contraction_Homo sapiens_hsa042601.08819229
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08430747
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07513348
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06684023
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06350886
62Glycerophospholipid metabolism_Homo sapiens_hsa005641.05492771
63GnRH signaling pathway_Homo sapiens_hsa049121.05230997
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04824852
65Peroxisome_Homo sapiens_hsa041461.04440824
66Serotonergic synapse_Homo sapiens_hsa047261.03695704
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02287735
68Drug metabolism - other enzymes_Homo sapiens_hsa009831.01843126
69Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01792537
70Other glycan degradation_Homo sapiens_hsa005110.99316266
71Arginine biosynthesis_Homo sapiens_hsa002200.99047261
72p53 signaling pathway_Homo sapiens_hsa041150.98232918
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97968894
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97533996
75Propanoate metabolism_Homo sapiens_hsa006400.97313814
76Hepatitis C_Homo sapiens_hsa051600.97059462
77Renin-angiotensin system_Homo sapiens_hsa046140.95273347
78Osteoclast differentiation_Homo sapiens_hsa043800.94333900
79Protein digestion and absorption_Homo sapiens_hsa049740.94309672
80Galactose metabolism_Homo sapiens_hsa000520.92863125
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92468200
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92175637
83B cell receptor signaling pathway_Homo sapiens_hsa046620.91969091
84Histidine metabolism_Homo sapiens_hsa003400.91949733
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90196575
86mTOR signaling pathway_Homo sapiens_hsa041500.89213505
87Steroid biosynthesis_Homo sapiens_hsa001000.87476285
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86426416
89Caffeine metabolism_Homo sapiens_hsa002320.84966475
90Mineral absorption_Homo sapiens_hsa049780.84919814
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82535391
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81186462
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80913826
94Staphylococcus aureus infection_Homo sapiens_hsa051500.80276920
95Leishmaniasis_Homo sapiens_hsa051400.80198172
96Tryptophan metabolism_Homo sapiens_hsa003800.80145769
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80064672
98Ras signaling pathway_Homo sapiens_hsa040140.78997458
99Renin secretion_Homo sapiens_hsa049240.78525177
100Wnt signaling pathway_Homo sapiens_hsa043100.78057381
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77970304
102FoxO signaling pathway_Homo sapiens_hsa040680.77852754
103Amoebiasis_Homo sapiens_hsa051460.74828420
104Phototransduction_Homo sapiens_hsa047440.74364156
105Huntingtons disease_Homo sapiens_hsa050160.74358942
106ErbB signaling pathway_Homo sapiens_hsa040120.74304399
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74223184
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74196641
109Salmonella infection_Homo sapiens_hsa051320.73854043
110Arginine and proline metabolism_Homo sapiens_hsa003300.73441754
111Pancreatic cancer_Homo sapiens_hsa052120.72669759
112Olfactory transduction_Homo sapiens_hsa047400.72508103
113Complement and coagulation cascades_Homo sapiens_hsa046100.72142597
114Chemical carcinogenesis_Homo sapiens_hsa052040.71130172
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70046669
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70037260
117Malaria_Homo sapiens_hsa051440.69070396
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.68889702
119Non-small cell lung cancer_Homo sapiens_hsa052230.66670596
120Endocytosis_Homo sapiens_hsa041440.66307527
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65570722
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64340164
123Pancreatic secretion_Homo sapiens_hsa049720.64170971
124Rap1 signaling pathway_Homo sapiens_hsa040150.64032429
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63481507
126Glioma_Homo sapiens_hsa052140.63251332
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.62797072
128Focal adhesion_Homo sapiens_hsa045100.60666469
129Pertussis_Homo sapiens_hsa051330.58936868
130Gap junction_Homo sapiens_hsa045400.58548364
131Retinol metabolism_Homo sapiens_hsa008300.58148347
132Chronic myeloid leukemia_Homo sapiens_hsa052200.57211231
133Glucagon signaling pathway_Homo sapiens_hsa049220.57040296
134Glutathione metabolism_Homo sapiens_hsa004800.56704416
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54681946
136Taste transduction_Homo sapiens_hsa047420.54309746
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.53636046
138Dopaminergic synapse_Homo sapiens_hsa047280.53420603
139Endometrial cancer_Homo sapiens_hsa052130.52037178
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51627482
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51176064
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.50960028
143MicroRNAs in cancer_Homo sapiens_hsa052060.50499962
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50016291
145Gastric acid secretion_Homo sapiens_hsa049710.49182165
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48918308
147Long-term depression_Homo sapiens_hsa047300.48343828
148Vitamin digestion and absorption_Homo sapiens_hsa049770.48041684
149Dorso-ventral axis formation_Homo sapiens_hsa043200.47956652
150Notch signaling pathway_Homo sapiens_hsa043300.47758070
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47542471
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46903378
153Salivary secretion_Homo sapiens_hsa049700.46492415
154ABC transporters_Homo sapiens_hsa020100.45789363
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.44771249
156Estrogen signaling pathway_Homo sapiens_hsa049150.44281509
157TNF signaling pathway_Homo sapiens_hsa046680.43011082
158Oxytocin signaling pathway_Homo sapiens_hsa049210.42768509
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41779691
160PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41543828
161Platelet activation_Homo sapiens_hsa046110.41262338
162Metabolic pathways_Homo sapiens_hsa011000.41058781
163Rheumatoid arthritis_Homo sapiens_hsa053230.40988390
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.40215047
165Choline metabolism in cancer_Homo sapiens_hsa052310.39093280
166Pathways in cancer_Homo sapiens_hsa052000.38357778
167Toxoplasmosis_Homo sapiens_hsa051450.37799231
168Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37428555
169Renal cell carcinoma_Homo sapiens_hsa052110.36804631
170Maturity onset diabetes of the young_Homo sapiens_hsa049500.35989665

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