HECTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.32794904
2L-phenylalanine catabolic process (GO:0006559)6.32794904
3aromatic amino acid family catabolic process (GO:0009074)6.02041882
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.80305659
5L-phenylalanine metabolic process (GO:0006558)5.80305659
6indole-containing compound catabolic process (GO:0042436)5.68330386
7indolalkylamine catabolic process (GO:0046218)5.68330386
8tryptophan catabolic process (GO:0006569)5.68330386
9tryptophan metabolic process (GO:0006568)5.33988788
10bile acid biosynthetic process (GO:0006699)5.16038281
11kynurenine metabolic process (GO:0070189)5.15611937
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.09552513
13urea metabolic process (GO:0019627)4.92276647
14urea cycle (GO:0000050)4.92276647
15high-density lipoprotein particle remodeling (GO:0034375)4.80986942
16dicarboxylic acid biosynthetic process (GO:0043650)4.72149195
17nitrogen cycle metabolic process (GO:0071941)4.48913368
18complement activation, alternative pathway (GO:0006957)4.48381500
19homocysteine metabolic process (GO:0050667)4.47048361
20glyoxylate metabolic process (GO:0046487)4.42969180
21bile acid metabolic process (GO:0008206)4.35169118
22regulation of protein activation cascade (GO:2000257)4.33275330
23regulation of fibrinolysis (GO:0051917)4.29633648
24peptidyl-glutamic acid carboxylation (GO:0017187)4.25027973
25protein carboxylation (GO:0018214)4.25027973
26cellular biogenic amine catabolic process (GO:0042402)4.23099037
27amine catabolic process (GO:0009310)4.23099037
28aromatic amino acid family metabolic process (GO:0009072)4.22050899
29tyrosine metabolic process (GO:0006570)4.19416609
30presynaptic membrane assembly (GO:0097105)4.17741789
31cysteine metabolic process (GO:0006534)4.14563514
32negative regulation of fibrinolysis (GO:0051918)4.10954288
33reverse cholesterol transport (GO:0043691)4.10357447
34indolalkylamine metabolic process (GO:0006586)4.06208708
35alpha-linolenic acid metabolic process (GO:0036109)4.05751073
36plasma lipoprotein particle remodeling (GO:0034369)4.03612950
37protein-lipid complex remodeling (GO:0034368)4.03612950
38macromolecular complex remodeling (GO:0034367)4.03612950
39regulation of complement activation (GO:0030449)4.02362727
40serine family amino acid catabolic process (GO:0009071)4.00826112
41alpha-amino acid catabolic process (GO:1901606)3.98053237
42sulfur amino acid catabolic process (GO:0000098)3.92775048
43triglyceride homeostasis (GO:0070328)3.91026754
44acylglycerol homeostasis (GO:0055090)3.91026754
45glutamate metabolic process (GO:0006536)3.90787163
46coenzyme catabolic process (GO:0009109)3.89512298
47cellular glucuronidation (GO:0052695)3.88581999
48amino-acid betaine metabolic process (GO:0006577)3.78009014
49negative regulation of lipase activity (GO:0060192)3.75568336
50presynaptic membrane organization (GO:0097090)3.71292448
51epoxygenase P450 pathway (GO:0019373)3.70094692
52regulation of triglyceride catabolic process (GO:0010896)3.68071681
53regulation of cholesterol esterification (GO:0010872)3.66174661
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66101942
55bile acid and bile salt transport (GO:0015721)3.65860992
56regulation of bile acid biosynthetic process (GO:0070857)3.64633068
57cholesterol efflux (GO:0033344)3.64071456
58low-density lipoprotein particle remodeling (GO:0034374)3.62584347
59phospholipid efflux (GO:0033700)3.62342438
60drug catabolic process (GO:0042737)3.61633675
61exogenous drug catabolic process (GO:0042738)3.57449667
62negative regulation of sterol transport (GO:0032372)3.57017128
63negative regulation of cholesterol transport (GO:0032375)3.57017128
64imidazole-containing compound metabolic process (GO:0052803)3.54194379
65cellular amino acid catabolic process (GO:0009063)3.53755022
66very-low-density lipoprotein particle assembly (GO:0034379)3.51938947
67nucleobase catabolic process (GO:0046113)3.51869364
68plasma lipoprotein particle clearance (GO:0034381)3.51290025
69cellular ketone body metabolic process (GO:0046950)3.51266356
70postsynaptic membrane organization (GO:0001941)3.51031414
71axonal fasciculation (GO:0007413)3.44621033
72cerebral cortex radially oriented cell migration (GO:0021799)3.43102712
73indole-containing compound metabolic process (GO:0042430)3.38079939
74glucuronate metabolic process (GO:0019585)3.36504637
75uronic acid metabolic process (GO:0006063)3.36504637
76blood coagulation, intrinsic pathway (GO:0007597)3.27562329
77retinal ganglion cell axon guidance (GO:0031290)3.27028294
78arginine metabolic process (GO:0006525)3.26180217
79pyrimidine nucleobase catabolic process (GO:0006208)3.21641964
80flavonoid metabolic process (GO:0009812)3.20594893
81neuronal action potential propagation (GO:0019227)3.19622520
82NAD biosynthetic process (GO:0009435)3.18468330
83neuron cell-cell adhesion (GO:0007158)3.16522649
84benzene-containing compound metabolic process (GO:0042537)3.16243969
85cytolysis (GO:0019835)3.16115050
86opsonization (GO:0008228)3.15375491
87cellular modified amino acid catabolic process (GO:0042219)3.15099538
88short-chain fatty acid metabolic process (GO:0046459)3.11925427
89protein activation cascade (GO:0072376)3.10034007
90plasma lipoprotein particle assembly (GO:0034377)3.10028148
91negative regulation of protein activation cascade (GO:2000258)3.07313826
92omega-hydroxylase P450 pathway (GO:0097267)3.05853952
93lysine catabolic process (GO:0006554)3.04805123
94lysine metabolic process (GO:0006553)3.04805123
95neuron recognition (GO:0008038)3.03660795
96fibrinolysis (GO:0042730)3.03387024
97plasma lipoprotein particle organization (GO:0071827)3.02873375
98gamma-aminobutyric acid transport (GO:0015812)3.01902255
99complement activation, classical pathway (GO:0006958)3.01073356
100complement activation (GO:0006956)2.99530484
101ketone body metabolic process (GO:1902224)2.98693813
102positive regulation of lipid catabolic process (GO:0050996)2.98073989
103pyrimidine nucleoside catabolic process (GO:0046135)2.97665726
104cofactor catabolic process (GO:0051187)2.96192388
105carboxylic acid catabolic process (GO:0046395)2.96172561
106organic acid catabolic process (GO:0016054)2.96172561
107intraciliary transport (GO:0042073)2.96078292
108positive regulation of triglyceride lipase activity (GO:0061365)2.95524284
109positive regulation of lipoprotein lipase activity (GO:0051006)2.95524284
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95020835
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94932485
112glutamine family amino acid biosynthetic process (GO:0009084)2.93621573
113phospholipid homeostasis (GO:0055091)2.92818778
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91006451
115nicotinamide nucleotide biosynthetic process (GO:0019359)2.88155825
116cerebral cortex cell migration (GO:0021795)2.73779516
117nonmotile primary cilium assembly (GO:0035058)2.70355401
118vocalization behavior (GO:0071625)2.69832359
119regulation of respiratory system process (GO:0044065)2.68711067
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67237537
121limb bud formation (GO:0060174)2.65893689
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65158138
123olfactory bulb development (GO:0021772)2.63997584
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63298386
125protein localization to synapse (GO:0035418)2.61267635
126negative regulation of oligodendrocyte differentiation (GO:0048715)2.59161211
127central nervous system projection neuron axonogenesis (GO:0021952)2.57325146
128synapse assembly (GO:0007416)2.54911148
129auditory behavior (GO:0031223)2.54505405
130neurotransmitter-gated ion channel clustering (GO:0072578)2.53926034
131dendrite morphogenesis (GO:0048813)2.53715260
132limb development (GO:0060173)2.51093406
133appendage development (GO:0048736)2.51093406
134protein localization to cilium (GO:0061512)2.46152900
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45760555
136glycosphingolipid biosynthetic process (GO:0006688)2.42818768
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.40983285
138dendritic spine morphogenesis (GO:0060997)2.40644194
139somite development (GO:0061053)2.39407042
140negative regulation of axon guidance (GO:1902668)2.38699919
141central nervous system neuron axonogenesis (GO:0021955)2.36385777
142regulation of phospholipase A2 activity (GO:0032429)2.36203869
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35304121
144cilium assembly (GO:0042384)2.34408476
145cilium morphogenesis (GO:0060271)2.32891809
146magnesium ion transport (GO:0015693)2.32494763
147atrial cardiac muscle cell action potential (GO:0086014)2.32489222
148cilium organization (GO:0044782)2.31921642
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31205248
150hippocampus development (GO:0021766)2.27572621
151homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.26534008
152protein prenylation (GO:0018342)2.26457055
153prenylation (GO:0097354)2.26457055
154glutamate receptor signaling pathway (GO:0007215)2.26446852
155behavioral response to nicotine (GO:0035095)2.26414019
156regulation of axon guidance (GO:1902667)2.26030750
157forebrain neuron differentiation (GO:0021879)2.25834342
158inner ear receptor stereocilium organization (GO:0060122)2.24458846
159C4-dicarboxylate transport (GO:0015740)2.24282331
160inner ear receptor cell development (GO:0060119)2.23532303
161regulation of dendritic spine morphogenesis (GO:0061001)2.23172970
162neuron projection extension involved in neuron projection guidance (GO:1902284)2.22883047
163axon extension involved in axon guidance (GO:0048846)2.22883047
164regulation of respiratory gaseous exchange (GO:0043576)2.21319312
165axon extension (GO:0048675)2.21176566
166regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17196550
167membrane depolarization during action potential (GO:0086010)2.16477025
168regulation of synapse assembly (GO:0051963)2.16328591
169establishment of nucleus localization (GO:0040023)2.16281754
170positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.16040186
171synaptic transmission, glutamatergic (GO:0035249)2.15950071
172ionotropic glutamate receptor signaling pathway (GO:0035235)2.15322792
173mechanosensory behavior (GO:0007638)2.15035755
174behavioral response to ethanol (GO:0048149)2.15007290
175innervation (GO:0060384)2.14287512
176ganglion development (GO:0061548)2.14260517
177positive regulation of synapse assembly (GO:0051965)2.14171544
178cochlea development (GO:0090102)2.14117804
179regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.14049968
180microtubule anchoring (GO:0034453)2.13975532
181epithelial cilium movement (GO:0003351)2.13105290
182neuron fate determination (GO:0048664)2.12113330
183positive regulation of mitochondrial fission (GO:0090141)2.12012151
184neuron migration (GO:0001764)2.10936691
185smoothened signaling pathway (GO:0007224)2.09993497
186proline transport (GO:0015824)2.09670663
187positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09618980
188regulation of non-canonical Wnt signaling pathway (GO:2000050)2.09554207
189synapse organization (GO:0050808)2.09369751
190response to pheromone (GO:0019236)2.08519434
191substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.07888823
192substrate-independent telencephalic tangential migration (GO:0021826)2.07888823
193reflex (GO:0060004)2.07386508
194DNA double-strand break processing (GO:0000729)2.06809110
195head development (GO:0060322)2.06646555
196sympathetic nervous system development (GO:0048485)2.06577726
197positive regulation of dendritic spine morphogenesis (GO:0061003)2.05709140
198neuron-neuron synaptic transmission (GO:0007270)2.05171017
199neuronal stem cell maintenance (GO:0097150)2.04850044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.46417985
2EZH2_22144423_ChIP-Seq_EOC_Human3.69012913
3GBX2_23144817_ChIP-Seq_PC3_Human3.63889263
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.38987813
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.29797783
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.83227347
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.64527582
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51815119
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48945629
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32761395
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25353709
12* TAF15_26573619_Chip-Seq_HEK293_Human2.23717952
13ZNF274_21170338_ChIP-Seq_K562_Hela2.15374430
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04846559
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93336992
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92596786
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89618465
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86336096
19EWS_26573619_Chip-Seq_HEK293_Human1.80915401
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78539472
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72800637
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72315379
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65330981
24* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63127328
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.62913143
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62003316
27P300_19829295_ChIP-Seq_ESCs_Human1.61574797
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59766888
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59642917
30SMAD4_21799915_ChIP-Seq_A2780_Human1.59258431
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58909075
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57589642
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.56363107
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55699255
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54951400
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54550157
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.54438118
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53926687
39RNF2_27304074_Chip-Seq_NSC_Mouse1.50726762
40* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49911950
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47867192
42HTT_18923047_ChIP-ChIP_STHdh_Human1.45652259
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45297532
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44184091
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43804887
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.42592626
47* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41354034
48CBP_20019798_ChIP-Seq_JUKART_Human1.41122380
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41122380
50DROSHA_22980978_ChIP-Seq_HELA_Human1.40211120
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38500980
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38500980
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38329107
54AR_21572438_ChIP-Seq_LNCaP_Human1.37118567
55* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36158164
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36049139
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35859701
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34246259
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33091563
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.32758101
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.32496264
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.31885038
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.30225716
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29340129
65STAT3_23295773_ChIP-Seq_U87_Human1.27984942
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.27775283
67P53_22387025_ChIP-Seq_ESCs_Mouse1.26503987
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.25733618
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23881100
70RUNX2_22187159_ChIP-Seq_PCA_Human1.23809025
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.23480659
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23163301
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22650946
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.22184475
75FUS_26573619_Chip-Seq_HEK293_Human1.21518911
76SOX9_26525672_Chip-Seq_HEART_Mouse1.19953326
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19046331
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18683753
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18085939
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17891859
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17822685
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17822685
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.17590519
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17541340
85REST_21632747_ChIP-Seq_MESCs_Mouse1.17306583
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16890832
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16833926
88IGF1R_20145208_ChIP-Seq_DFB_Human1.16712906
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.16623237
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16338858
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16154406
92AR_25329375_ChIP-Seq_VCAP_Human1.15905467
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15002512
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14660130
95TCF4_23295773_ChIP-Seq_U87_Human1.14243504
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14148991
97BCAT_22108803_ChIP-Seq_LS180_Human1.13945239
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13845938
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13812119
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13796401
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13406765
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13342780
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12755955
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.12517132
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11905985
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.11673421
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11449944
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10568796
109* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09593631
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.08628630
111VDR_22108803_ChIP-Seq_LS180_Human1.08397893
112* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08389651
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08087578
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07820469
115SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07319175
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07270967
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.07235389
118ER_23166858_ChIP-Seq_MCF-7_Human1.06556986
119* KDM2B_26808549_Chip-Seq_REH_Human1.06336463
120P300_18555785_Chip-Seq_ESCs_Mouse1.06274641
121JUN_21703547_ChIP-Seq_K562_Human1.06194559
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06136652
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.05797524
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04479568
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.03557032
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03104147
127PU1_27457419_Chip-Seq_LIVER_Mouse1.02816987
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02554831
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.02228326
130CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02024890
131TP53_18474530_ChIP-ChIP_U2OS_Human1.01772649
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.01557919
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01425076
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01425076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.11608375
2MP0005360_urolithiasis6.18428127
3MP0005085_abnormal_gallbladder_physiolo5.61708849
4MP0005365_abnormal_bile_salt5.33809679
5MP0008875_abnormal_xenobiotic_pharmacok4.57138071
6MP0003252_abnormal_bile_duct3.46485458
7MP0004859_abnormal_synaptic_plasticity2.75881933
8MP0010329_abnormal_lipoprotein_level2.74209647
9MP0003122_maternal_imprinting2.59932460
10MP0003806_abnormal_nucleotide_metabolis2.51926071
11MP0003195_calcinosis2.46008988
12MP0009697_abnormal_copulation2.19628702
13MP0003880_abnormal_central_pattern2.14704357
14MP0005248_abnormal_Harderian_gland2.14652292
15MP0003868_abnormal_feces_composition2.05003094
16MP0005332_abnormal_amino_acid1.93553956
17MP0002638_abnormal_pupillary_reflex1.88742918
18MP0003121_genomic_imprinting1.87988204
19MP0002736_abnormal_nociception_after1.86401807
20MP0005083_abnormal_biliary_tract1.84937011
21MP0005670_abnormal_white_adipose1.84478277
22MP0006072_abnormal_retinal_apoptosis1.74756582
23MP0001666_abnormal_nutrient_absorption1.74057470
24MP0002735_abnormal_chemical_nociception1.73138575
25MP0001529_abnormal_vocalization1.69926549
26MP0005187_abnormal_penis_morphology1.69071210
27MP0004019_abnormal_vitamin_homeostasis1.67460257
28MP0002876_abnormal_thyroid_physiology1.66909849
29MP0002118_abnormal_lipid_homeostasis1.64837038
30MP0009745_abnormal_behavioral_response1.64684870
31MP0005451_abnormal_body_composition1.64411667
32MP0001968_abnormal_touch/_nociception1.61360472
33MP0004133_heterotaxia1.59061902
34MP0000631_abnormal_neuroendocrine_gland1.57655391
35MP0003635_abnormal_synaptic_transmissio1.51844131
36MP0003937_abnormal_limbs/digits/tail_de1.49603178
37MP0005646_abnormal_pituitary_gland1.48690971
38MP0001299_abnormal_eye_distance/1.45461480
39MP0008789_abnormal_olfactory_epithelium1.45411959
40MP0002653_abnormal_ependyma_morphology1.45016855
41MP0004215_abnormal_myocardial_fiber1.44657363
42MP0002063_abnormal_learning/memory/cond1.42224038
43MP0002138_abnormal_hepatobiliary_system1.41765398
44MP0003787_abnormal_imprinting1.41534880
45MP0002572_abnormal_emotion/affect_behav1.40008651
46MP0009840_abnormal_foam_cell1.39490695
47MP0005253_abnormal_eye_physiology1.39065583
48MP0000609_abnormal_liver_physiology1.38665527
49MP0001984_abnormal_olfaction1.38549770
50MP0000049_abnormal_middle_ear1.33754403
51MP0002234_abnormal_pharynx_morphology1.33053443
52MP0002233_abnormal_nose_morphology1.32399985
53MP0001486_abnormal_startle_reflex1.29499388
54MP0001501_abnormal_sleep_pattern1.29454733
55MP0001440_abnormal_grooming_behavior1.29377209
56MP0002064_seizures1.29288852
57MP0000751_myopathy1.28821196
58MP0002938_white_spotting1.28667095
59MP0003890_abnormal_embryonic-extraembry1.25918147
60MP0005647_abnormal_sex_gland1.22932675
61MP0009780_abnormal_chondrocyte_physiolo1.21860069
62MP0005499_abnormal_olfactory_system1.21325033
63MP0005394_taste/olfaction_phenotype1.21325033
64MP0000566_synostosis1.20828278
65MP0000383_abnormal_hair_follicle1.20282884
66MP0005319_abnormal_enzyme/_coenzyme1.20192662
67MP0002697_abnormal_eye_size1.19377399
68MP0003755_abnormal_palate_morphology1.19329498
69MP0003191_abnormal_cellular_cholesterol1.14829974
70MP0005584_abnormal_enzyme/coenzyme_acti1.13969582
71MP0004145_abnormal_muscle_electrophysio1.12693747
72MP0002882_abnormal_neuron_morphology1.09031236
73MP0009046_muscle_twitch1.08966943
74MP0001764_abnormal_homeostasis1.08065007
75MP0003119_abnormal_digestive_system1.07386645
76MP0000013_abnormal_adipose_tissue1.07372735
77MP0003137_abnormal_impulse_conducting1.06671377
78MP0003011_delayed_dark_adaptation1.06388393
79MP0002751_abnormal_autonomic_nervous1.05294247
80MP0002272_abnormal_nervous_system1.05180199
81MP0003283_abnormal_digestive_organ1.04551426
82MP0001293_anophthalmia1.04508321
83MP0004811_abnormal_neuron_physiology1.03880497
84MP0003385_abnormal_body_wall1.03358724
85MP0002752_abnormal_somatic_nervous1.02908914
86MP0000647_abnormal_sebaceous_gland1.02164348
87MP0009764_decreased_sensitivity_to1.02067668
88MP0010678_abnormal_skin_adnexa1.01510320
89MP0003690_abnormal_glial_cell1.00526824
90MP0002067_abnormal_sensory_capabilities0.98811210
91MP0004270_analgesia0.98622776
92MP0003938_abnormal_ear_development0.97884635
93MP0003861_abnormal_nervous_system0.96538860
94MP0006276_abnormal_autonomic_nervous0.96233787
95MP0002152_abnormal_brain_morphology0.95161978
96MP0004142_abnormal_muscle_tone0.92348380
97MP0004043_abnormal_pH_regulation0.92120686
98MP0005535_abnormal_body_temperature0.91091180
99MP0002822_catalepsy0.90844985
100MP0001661_extended_life_span0.90809140
101MP0003935_abnormal_craniofacial_develop0.90062791
102MP0005391_vision/eye_phenotype0.89317880
103MP0000778_abnormal_nervous_system0.88359046
104MP0001286_abnormal_eye_development0.87904211
105MP0003136_yellow_coat_color0.87821975
106MP0002909_abnormal_adrenal_gland0.87482869
107MP0005195_abnormal_posterior_eye0.87337543
108MP0008874_decreased_physiological_sensi0.87082950
109MP0005171_absent_coat_pigmentation0.86466560
110MP0004085_abnormal_heartbeat0.85046380
111MP0001970_abnormal_pain_threshold0.84681803
112MP0003942_abnormal_urinary_system0.83373369
113MP0003221_abnormal_cardiomyocyte_apopto0.82810444
114MP0002971_abnormal_brown_adipose0.82727801
115MP0009765_abnormal_xenobiotic_induced0.82387901
116MP0000462_abnormal_digestive_system0.82073451
117MP0010368_abnormal_lymphatic_system0.80754853
118MP0004130_abnormal_muscle_cell0.80672223
119MP0000579_abnormal_nail_morphology0.80484334
120MP0000604_amyloidosis0.79361796
121MP0005334_abnormal_fat_pad0.79332280
122MP0002733_abnormal_thermal_nociception0.79248409
123MP0005551_abnormal_eye_electrophysiolog0.78864290
124MP0005620_abnormal_muscle_contractility0.78738507
125MP0004381_abnormal_hair_follicle0.75720679
126MP0001502_abnormal_circadian_rhythm0.75567593
127MP0008877_abnormal_DNA_methylation0.73032978
128MP0006292_abnormal_olfactory_placode0.72714238
129MP0002557_abnormal_social/conspecific_i0.71320838
130MP0000569_abnormal_digit_pigmentation0.68987327
131MP0009763_increased_sensitivity_to0.68486303
132MP0002078_abnormal_glucose_homeostasis0.65162334
133MP0002184_abnormal_innervation0.64302254
134MP0000955_abnormal_spinal_cord0.63304088
135MP0004885_abnormal_endolymph0.63091183
136MP0002254_reproductive_system_inflammat0.63042583
137MP0005448_abnormal_energy_balance0.62923271
138MP0001188_hyperpigmentation0.61993075
139MP0001177_atelectasis0.61744820
140MP0003879_abnormal_hair_cell0.61076062
141MP0002837_dystrophic_cardiac_calcinosis0.60387419
142MP0003329_amyloid_beta_deposits0.59251198
143MP0002734_abnormal_mechanical_nocicepti0.58605513
144MP0005645_abnormal_hypothalamus_physiol0.57462386
145MP0004924_abnormal_behavior0.56787805
146MP0005386_behavior/neurological_phenoty0.56787805
147MP0009642_abnormal_blood_homeostasis0.56756553
148MP0002102_abnormal_ear_morphology0.53693835
149MP0003633_abnormal_nervous_system0.53009488
150MP0002069_abnormal_eating/drinking_beha0.51242897
151MP0005636_abnormal_mineral_homeostasis0.47887146
152MP0002066_abnormal_motor_capabilities/c0.47611168
153MP0001963_abnormal_hearing_physiology0.47122256
154MP0000026_abnormal_inner_ear0.46730056
155MP0000427_abnormal_hair_cycle0.46598107
156MP0003631_nervous_system_phenotype0.46116610
157MP0005423_abnormal_somatic_nervous0.45701175
158MP0005595_abnormal_vascular_smooth0.45512724

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.39707002
2Deep venous thrombosis (HP:0002625)6.32075974
3Prolonged partial thromboplastin time (HP:0003645)6.28033237
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.97763708
5Hypobetalipoproteinemia (HP:0003563)5.73546618
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11406886
7Xanthomatosis (HP:0000991)4.92275279
8Hyperlipoproteinemia (HP:0010980)4.74445476
9Complement deficiency (HP:0004431)4.58582990
10Epidermoid cyst (HP:0200040)4.45906032
11Joint hemorrhage (HP:0005261)4.45675458
12Abnormality of methionine metabolism (HP:0010901)4.37763632
13Hypolipoproteinemia (HP:0010981)4.21210709
14Conjugated hyperbilirubinemia (HP:0002908)4.14856516
15Focal motor seizures (HP:0011153)3.96127528
16Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89498961
17Hyperventilation (HP:0002883)3.88260967
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83599787
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.70108919
20Hyperammonemia (HP:0001987)3.67238142
21Hypoalphalipoproteinemia (HP:0003233)3.63181725
22Hyperglycinemia (HP:0002154)3.62100189
23Abnormality of the common coagulation pathway (HP:0010990)3.58918513
24Fat malabsorption (HP:0002630)3.43408495
25Ketosis (HP:0001946)3.39870596
26Fair hair (HP:0002286)3.35529810
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.27647457
28Abnormality of the intrinsic pathway (HP:0010989)3.18550738
29Type II lissencephaly (HP:0007260)3.15864823
30Abnormality of pyrimidine metabolism (HP:0004353)3.15037276
31Abnormality of complement system (HP:0005339)3.07583608
32Spontaneous abortion (HP:0005268)3.03749978
33Abnormality of serum amino acid levels (HP:0003112)3.03743421
34Gait imbalance (HP:0002141)2.95493662
35Medial flaring of the eyebrow (HP:0010747)2.95246302
36Hypercholesterolemia (HP:0003124)2.93128184
37Congenital primary aphakia (HP:0007707)2.80265083
38Abnormality of glycine metabolism (HP:0010895)2.79621638
39Abnormality of serine family amino acid metabolism (HP:0010894)2.79621638
40Febrile seizures (HP:0002373)2.79229436
41Pancreatic cysts (HP:0001737)2.77740717
42Hypochromic microcytic anemia (HP:0004840)2.74570927
43Atonic seizures (HP:0010819)2.72068449
44Pancreatic fibrosis (HP:0100732)2.70811003
45Retinal dysplasia (HP:0007973)2.66669258
46Abnormality of the labia minora (HP:0012880)2.66548433
47Delayed CNS myelination (HP:0002188)2.61787060
48Genital tract atresia (HP:0001827)2.61361262
49Nephrogenic diabetes insipidus (HP:0009806)2.61024531
50Cerebellar dysplasia (HP:0007033)2.59570850
51Hyperglycinuria (HP:0003108)2.57329138
52Blue irides (HP:0000635)2.56097137
53Vaginal atresia (HP:0000148)2.54598406
54Polyphagia (HP:0002591)2.54367434
55True hermaphroditism (HP:0010459)2.53840230
56Hypoglycemic coma (HP:0001325)2.53574007
57Steatorrhea (HP:0002570)2.52117477
58Metabolic acidosis (HP:0001942)2.51885392
59Chronic hepatic failure (HP:0100626)2.51683438
60Ketoacidosis (HP:0001993)2.50341957
61Acanthocytosis (HP:0001927)2.50299933
62Nephronophthisis (HP:0000090)2.46608563
63Skin nodule (HP:0200036)2.44584245
64Generalized hypopigmentation of hair (HP:0011358)2.42812320
65Status epilepticus (HP:0002133)2.42782917
66Vascular calcification (HP:0004934)2.39660631
67Cutaneous finger syndactyly (HP:0010554)2.38627468
68Confusion (HP:0001289)2.34660478
69Lissencephaly (HP:0001339)2.34171941
70Methylmalonic acidemia (HP:0002912)2.33933776
71Hyperbilirubinemia (HP:0002904)2.31044524
72Opisthotonus (HP:0002179)2.27755245
73Potter facies (HP:0002009)2.25585033
74Facial shape deformation (HP:0011334)2.25585033
75Epileptic encephalopathy (HP:0200134)2.19966734
76Papillary thyroid carcinoma (HP:0002895)2.19220265
77Hypoglycemic seizures (HP:0002173)2.19214739
78Abnormality of nucleobase metabolism (HP:0010932)2.18292129
79Myocardial infarction (HP:0001658)2.18127193
80Broad-based gait (HP:0002136)2.17626359
81Optic nerve hypoplasia (HP:0000609)2.16073542
82Hepatoblastoma (HP:0002884)2.15547218
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.14805250
84Abnormality of the renal medulla (HP:0100957)2.14440647
85Enlarged kidneys (HP:0000105)2.14076619
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12545482
87Postaxial hand polydactyly (HP:0001162)2.12316003
88Hepatocellular carcinoma (HP:0001402)2.11814389
89Hyperinsulinemic hypoglycemia (HP:0000825)2.11316328
90Septo-optic dysplasia (HP:0100842)2.09211907
91Renal cortical cysts (HP:0000803)2.07046245
92Cardiovascular calcification (HP:0011915)2.05619537
93Colon cancer (HP:0003003)2.04519086
94Dialeptic seizures (HP:0011146)2.04207053
95Recurrent gram-negative bacterial infections (HP:0005420)2.03885829
96Gingival bleeding (HP:0000225)2.03030182
97Molar tooth sign on MRI (HP:0002419)2.02999405
98Abnormality of midbrain morphology (HP:0002418)2.02999405
99Progressive cerebellar ataxia (HP:0002073)2.00732561
100Abnormality of vitamin metabolism (HP:0100508)2.00227342
101Abnormality of the ischium (HP:0003174)1.99612200
102Postaxial foot polydactyly (HP:0001830)1.99597558
103Cutaneous syndactyly (HP:0012725)1.98785676
104Preaxial foot polydactyly (HP:0001841)1.95571097
105Sensorimotor neuropathy (HP:0007141)1.94917257
106Absence seizures (HP:0002121)1.94630700
107Short tibia (HP:0005736)1.94630631
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.94197622
109Poor coordination (HP:0002370)1.88053749
110Bile duct proliferation (HP:0001408)1.88040857
111Abnormal biliary tract physiology (HP:0012439)1.88040857
112Occipital encephalocele (HP:0002085)1.87282506
113Abnormality of fatty-acid metabolism (HP:0004359)1.86513576
114Hypophosphatemic rickets (HP:0004912)1.86056562
115Generalized tonic-clonic seizures (HP:0002069)1.84225025
116Menorrhagia (HP:0000132)1.82595701
117Symptomatic seizures (HP:0011145)1.82558026
118Broad foot (HP:0001769)1.82445985
119Dicarboxylic aciduria (HP:0003215)1.82417169
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82417169
121Short foot (HP:0001773)1.82405711
122Neonatal onset (HP:0003623)1.81828100
123Pachygyria (HP:0001302)1.81363245
124Cystic liver disease (HP:0006706)1.80298882
125Micropenis (HP:0000054)1.79446593
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79341910
127Tubulointerstitial nephritis (HP:0001970)1.79285748
128Mitral stenosis (HP:0001718)1.79191166
129Lethargy (HP:0001254)1.78422275
130Epileptiform EEG discharges (HP:0011182)1.78211628
131Hemiparesis (HP:0001269)1.77551926
132Toxemia of pregnancy (HP:0100603)1.77171208
133Aplasia/Hypoplasia of the lens (HP:0008063)1.77008701
134Supernumerary spleens (HP:0009799)1.76602778
135Focal seizures (HP:0007359)1.76217546
136Limb dystonia (HP:0002451)1.76137333
137Specific learning disability (HP:0001328)1.75316403
138Oligodactyly (hands) (HP:0001180)1.74621393
139Systemic lupus erythematosus (HP:0002725)1.74417081
140Narrow forehead (HP:0000341)1.74333425
141Cortical dysplasia (HP:0002539)1.73846253
142Drooling (HP:0002307)1.72709986
143Excessive salivation (HP:0003781)1.72709986
144Abnormal gallbladder morphology (HP:0012437)1.71003107
145Tubular atrophy (HP:0000092)1.70952797
146Synostosis involving the elbow (HP:0003938)1.70589901
147Humeroradial synostosis (HP:0003041)1.70589901
148EEG with generalized epileptiform discharges (HP:0011198)1.70476628
149Hypsarrhythmia (HP:0002521)1.70077081
150Abnormality of purine metabolism (HP:0004352)1.69919556
151Intestinal atresia (HP:0011100)1.69752150
152Neonatal respiratory distress (HP:0002643)1.69509838
153Renal dysplasia (HP:0000110)1.68630476
154Renal hypoplasia (HP:0000089)1.67381815
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66948416
156Abnormality of the renal cortex (HP:0011035)1.66373253
157Volvulus (HP:0002580)1.66195564
158Urinary urgency (HP:0000012)1.65853738
159Fibular aplasia (HP:0002990)1.65692930
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.65514432
161Absent/shortened dynein arms (HP:0200106)1.65514432
162Absent speech (HP:0001344)1.63799834
163Labial hypoplasia (HP:0000066)1.63073784
164Impaired vibration sensation in the lower limbs (HP:0002166)1.62763631
165Abnormality of homocysteine metabolism (HP:0010919)1.62404949
166Homocystinuria (HP:0002156)1.62404949
167Absent eyebrow (HP:0002223)1.62404043
168Sclerocornea (HP:0000647)1.62176577
169Amyloidosis (HP:0011034)1.61070477
170Abnormality of the musculature of the pelvis (HP:0001469)1.60722484
171Abnormality of the hip-girdle musculature (HP:0001445)1.60722484
172Protruding tongue (HP:0010808)1.60427153
173Inability to walk (HP:0002540)1.60136779
174Abnormality of the calf musculature (HP:0001430)1.59903390
175Tented upper lip vermilion (HP:0010804)1.58406889
176Abnormality of the astrocytes (HP:0100707)1.58188825
177Astrocytoma (HP:0009592)1.58188825
178Pheochromocytoma (HP:0002666)1.57618257
179Glioma (HP:0009733)1.56630472
180Congenital hepatic fibrosis (HP:0002612)1.56047253
181Esotropia (HP:0000565)1.55943309
182Keratoconus (HP:0000563)1.55876641
183Increased corneal curvature (HP:0100692)1.55876641
184Bifid tongue (HP:0010297)1.55856380
185Shoulder girdle muscle weakness (HP:0003547)1.54977194
186Hypoplastic ischia (HP:0003175)1.54803515
187Aplasia/Hypoplasia of the sternum (HP:0006714)1.54782894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.29027934
2NTRK33.94743911
3INSRR3.12886946
4CASK3.07745163
5WNK32.81834571
6FRK2.57320511
7MAP4K22.40647265
8ERBB42.34902739
9MAP2K72.33164962
10ERBB32.31720436
11BCR2.20406360
12SIK12.20063671
13MAP3K42.18814485
14MAP2K42.10996788
15TNIK1.95451277
16STK161.77719058
17PRPF4B1.72406584
18NTRK21.64143830
19LATS11.63949877
20PNCK1.63676849
21TAOK31.63052910
22SGK21.53639713
23MKNK21.49606053
24BMPR21.38148577
25DAPK21.38099179
26CSNK1G11.36216984
27MARK11.34035667
28MINK11.32536275
29BCKDK1.31561593
30MUSK1.30325294
31PINK11.30010427
32PRKAA21.29548542
33MAPK131.29296210
34MKNK11.26301204
35FGFR41.22408275
36NUAK11.21348042
37MAP3K71.18305939
38AKT31.18077163
39PKN11.17889319
40TAOK21.17476030
41CSNK1G31.17150909
42MAP3K141.14838987
43DYRK21.14344019
44MAP3K131.13625517
45DYRK31.13551242
46BMPR1B1.12417321
47SGK2231.11347933
48SGK4941.11347933
49SRPK11.11289922
50CAMKK21.07453265
51SGK31.06598977
52TXK1.05611041
53PRKCG1.05247705
54CAMK2A1.04961824
55SIK31.04792527
56CAMK1G1.01319113
57BRSK21.00394684
58BRD40.98165141
59PLK20.98037316
60PRKD30.98018161
61SGK10.97352640
62MAP3K60.95203054
63FGFR20.95103316
64CAMK1D0.94062967
65CSNK1G20.93333889
66CAMK2B0.93000471
67MARK20.90792620
68EPHA30.90080385
69OBSCN0.88769833
70TRIM280.87732286
71PHKG20.87276832
72PHKG10.87276832
73MAPK70.87020415
74MAPK110.86706829
75CCNB10.86701294
76SIK20.86436293
77IRAK10.86152247
78PIK3CG0.85750339
79CDK190.85365966
80PRKCQ0.83817721
81WEE10.81094008
82NEK10.80584703
83CDK30.77913325
84CAMK2G0.77491690
85EIF2AK30.76878137
86EIF2AK10.74558449
87EIF2AK20.74504157
88PRKCE0.74303303
89KSR10.74263443
90PRKAA10.74154167
91UHMK10.72169806
92EPHB20.72136800
93MAPK120.71259576
94ACVR1B0.70604872
95PRKG10.65915850
96JAK10.64399834
97NEK60.64211482
98PRKCZ0.63895177
99FES0.63645379
100CAMKK10.63555463
101ZAK0.61989725
102YES10.61871126
103STK390.61170700
104MAP3K50.61033632
105GRK10.60789124
106RPS6KA40.60655116
107ADRBK20.60467311
108MET0.58283149
109CDK50.57854206
110PLK30.57808449
111PLK40.57110189
112FER0.56674866
113STK30.54685987
114CAMK10.52956488
115PIK3CA0.52308211
116ABL20.51803460
117IGF1R0.51744094
118STK38L0.51025952
119CAMK40.50974982
120CAMK2D0.50872684
121MAPK150.50371195
122LATS20.49823006
123PRKACG0.48751986
124PRKACB0.47514128
125PAK60.46797060
126NEK90.46472494
127OXSR10.46078169
128STK380.45973129
129RPS6KA30.44985364
130PRKCA0.44611822
131PRKCB0.44223487
132MAP2K60.43427875
133PLK10.43398729
134PRKACA0.43340035
135ERBB20.41659525
136DYRK1A0.40768108
137CSNK1A10.40524289
138VRK10.39059832
139GRK70.38493100
140STK110.38375334
141CSNK1A1L0.38149218
142PAK30.38065069
143PTK2B0.37458944
144ATM0.36811809
145MAP3K90.36092208
146CDK180.35724668
147CDC70.34022958

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48840527
2Nitrogen metabolism_Homo sapiens_hsa009103.18186382
3Arginine biosynthesis_Homo sapiens_hsa002203.17074113
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96558997
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93970218
6Complement and coagulation cascades_Homo sapiens_hsa046102.62045523
7Tryptophan metabolism_Homo sapiens_hsa003802.50912937
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45237505
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.38033935
10Protein export_Homo sapiens_hsa030602.24699118
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07649500
12Fatty acid degradation_Homo sapiens_hsa000712.06534459
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02039416
14Retinol metabolism_Homo sapiens_hsa008301.95965748
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95755464
16Butanoate metabolism_Homo sapiens_hsa006501.94434440
17Histidine metabolism_Homo sapiens_hsa003401.93644746
18Peroxisome_Homo sapiens_hsa041461.88747990
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.83659276
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81357109
21Caffeine metabolism_Homo sapiens_hsa002321.78984050
22Chemical carcinogenesis_Homo sapiens_hsa052041.75979099
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75341355
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71283818
25PPAR signaling pathway_Homo sapiens_hsa033201.65540915
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64487362
27Nicotine addiction_Homo sapiens_hsa050331.62470637
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62004000
29Fatty acid metabolism_Homo sapiens_hsa012121.60768313
30Propanoate metabolism_Homo sapiens_hsa006401.59315121
31beta-Alanine metabolism_Homo sapiens_hsa004101.57532294
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55024518
33Staphylococcus aureus infection_Homo sapiens_hsa051501.54533936
34Bile secretion_Homo sapiens_hsa049761.54058930
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48210269
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46532081
37Fatty acid elongation_Homo sapiens_hsa000621.40297925
38Phototransduction_Homo sapiens_hsa047441.40162546
39Phenylalanine metabolism_Homo sapiens_hsa003601.36600545
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32103202
41Basal transcription factors_Homo sapiens_hsa030221.28944272
42ABC transporters_Homo sapiens_hsa020101.28686401
43Tyrosine metabolism_Homo sapiens_hsa003501.28252582
44Hippo signaling pathway_Homo sapiens_hsa043901.27327753
45Steroid biosynthesis_Homo sapiens_hsa001001.24735591
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.23761478
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21648713
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.18615066
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18310262
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18142298
51Basal cell carcinoma_Homo sapiens_hsa052171.15899712
52Regulation of autophagy_Homo sapiens_hsa041401.14720267
53Starch and sucrose metabolism_Homo sapiens_hsa005001.14193253
54Hedgehog signaling pathway_Homo sapiens_hsa043401.11872253
55Selenocompound metabolism_Homo sapiens_hsa004501.10539462
56TGF-beta signaling pathway_Homo sapiens_hsa043501.07512225
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07449316
58Vitamin digestion and absorption_Homo sapiens_hsa049771.06928481
59Synaptic vesicle cycle_Homo sapiens_hsa047211.06849490
60Sulfur metabolism_Homo sapiens_hsa009201.05785253
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04973245
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01467449
63Fanconi anemia pathway_Homo sapiens_hsa034600.99647983
64Pyruvate metabolism_Homo sapiens_hsa006200.97224768
65Oocyte meiosis_Homo sapiens_hsa041140.96698004
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93631904
67Dilated cardiomyopathy_Homo sapiens_hsa054140.92484727
68Glutamatergic synapse_Homo sapiens_hsa047240.92277411
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90031864
70Renin-angiotensin system_Homo sapiens_hsa046140.89702798
71Gap junction_Homo sapiens_hsa045400.89522827
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88594546
73Cardiac muscle contraction_Homo sapiens_hsa042600.87692285
74Lysine degradation_Homo sapiens_hsa003100.87669851
75Cholinergic synapse_Homo sapiens_hsa047250.80428558
76Fatty acid biosynthesis_Homo sapiens_hsa000610.78690895
77Wnt signaling pathway_Homo sapiens_hsa043100.78510066
78GABAergic synapse_Homo sapiens_hsa047270.77979931
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76480068
80Arginine and proline metabolism_Homo sapiens_hsa003300.76158927
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74095620
82Oxytocin signaling pathway_Homo sapiens_hsa049210.73173892
83Melanogenesis_Homo sapiens_hsa049160.73024589
84Tight junction_Homo sapiens_hsa045300.69501843
85Vitamin B6 metabolism_Homo sapiens_hsa007500.67308933
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.66866859
87Gastric acid secretion_Homo sapiens_hsa049710.65735478
88Non-homologous end-joining_Homo sapiens_hsa034500.64419466
89Fat digestion and absorption_Homo sapiens_hsa049750.64192880
90Morphine addiction_Homo sapiens_hsa050320.62725584
91Circadian entrainment_Homo sapiens_hsa047130.62688375
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58910987
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.58807165
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58318133
95Adherens junction_Homo sapiens_hsa045200.56769325
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56422666
97Glycerolipid metabolism_Homo sapiens_hsa005610.56059761
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54987738
99Homologous recombination_Homo sapiens_hsa034400.54908383
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53858531
101Collecting duct acid secretion_Homo sapiens_hsa049660.53178294
102Alcoholism_Homo sapiens_hsa050340.52642131
103Ovarian steroidogenesis_Homo sapiens_hsa049130.50469380
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48360550
105Amphetamine addiction_Homo sapiens_hsa050310.47873044
106AMPK signaling pathway_Homo sapiens_hsa041520.46677299
107Taste transduction_Homo sapiens_hsa047420.46292523
108Olfactory transduction_Homo sapiens_hsa047400.45742877
109Biosynthesis of amino acids_Homo sapiens_hsa012300.45418541
110mRNA surveillance pathway_Homo sapiens_hsa030150.41850062
111Thyroid hormone synthesis_Homo sapiens_hsa049180.41814351
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41664619
113RNA degradation_Homo sapiens_hsa030180.39993191
114Oxidative phosphorylation_Homo sapiens_hsa001900.39908287
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.36962760
116Carbon metabolism_Homo sapiens_hsa012000.36890931
117Calcium signaling pathway_Homo sapiens_hsa040200.36418003
118Long-term potentiation_Homo sapiens_hsa047200.34606696
119Prion diseases_Homo sapiens_hsa050200.33092494
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32064954
121Folate biosynthesis_Homo sapiens_hsa007900.31800650
122Metabolic pathways_Homo sapiens_hsa011000.31785054
123Glucagon signaling pathway_Homo sapiens_hsa049220.30708000
124Cocaine addiction_Homo sapiens_hsa050300.29865379
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.27624857
126Insulin secretion_Homo sapiens_hsa049110.27483329
127Circadian rhythm_Homo sapiens_hsa047100.25831882
128Type II diabetes mellitus_Homo sapiens_hsa049300.25608403
129Linoleic acid metabolism_Homo sapiens_hsa005910.25000241
130cAMP signaling pathway_Homo sapiens_hsa040240.22031601
131Long-term depression_Homo sapiens_hsa047300.21176700
132Salivary secretion_Homo sapiens_hsa049700.21116942
133Axon guidance_Homo sapiens_hsa043600.18987020
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.17809209
135Serotonergic synapse_Homo sapiens_hsa047260.17685119
136Dopaminergic synapse_Homo sapiens_hsa047280.15728175
137Renin secretion_Homo sapiens_hsa049240.14210291
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12755458
139Insulin resistance_Homo sapiens_hsa049310.11862577
140Ether lipid metabolism_Homo sapiens_hsa005650.10702961
141African trypanosomiasis_Homo sapiens_hsa051430.10523818
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10000379
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09317836
144Sulfur relay system_Homo sapiens_hsa041220.08627588
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08407191

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