HECTD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.85606037
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.85606037
3L-phenylalanine metabolic process (GO:0006558)5.63168927
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.63168927
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55387981
6aromatic amino acid family catabolic process (GO:0009074)5.10072663
7alpha-linolenic acid metabolic process (GO:0036109)5.05156215
8kynurenine metabolic process (GO:0070189)4.69755103
9urea metabolic process (GO:0019627)4.67848872
10urea cycle (GO:0000050)4.67848872
11cysteine metabolic process (GO:0006534)4.54722117
12indolalkylamine catabolic process (GO:0046218)4.51940716
13tryptophan catabolic process (GO:0006569)4.51940716
14indole-containing compound catabolic process (GO:0042436)4.51940716
15lysine metabolic process (GO:0006553)4.50712061
16lysine catabolic process (GO:0006554)4.50712061
17high-density lipoprotein particle remodeling (GO:0034375)4.50091162
18bile acid biosynthetic process (GO:0006699)4.43145933
19sulfur amino acid catabolic process (GO:0000098)4.41458328
20glyoxylate metabolic process (GO:0046487)4.38967870
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35701937
22regulation of triglyceride catabolic process (GO:0010896)4.35391816
23negative regulation of cholesterol transport (GO:0032375)4.32020700
24negative regulation of sterol transport (GO:0032372)4.32020700
25nitrogen cycle metabolic process (GO:0071941)4.26177665
26tryptophan metabolic process (GO:0006568)4.23417902
27phospholipid efflux (GO:0033700)4.20578254
28complement activation, alternative pathway (GO:0006957)4.19942080
29Golgi transport vesicle coating (GO:0048200)4.17631528
30COPI coating of Golgi vesicle (GO:0048205)4.17631528
31reverse cholesterol transport (GO:0043691)4.11035474
32negative regulation of fibrinolysis (GO:0051918)4.10197655
33peptidyl-glutamic acid carboxylation (GO:0017187)4.07603535
34protein carboxylation (GO:0018214)4.07603535
35regulation of cholesterol esterification (GO:0010872)4.04220537
36NADH metabolic process (GO:0006734)4.00165995
37regulation of cholesterol homeostasis (GO:2000188)3.99816499
38bile acid metabolic process (GO:0008206)3.99276794
39homocysteine metabolic process (GO:0050667)3.99269917
40regulation of protein activation cascade (GO:2000257)3.98764330
41negative regulation of erythrocyte differentiation (GO:0045647)3.96129604
42serine family amino acid catabolic process (GO:0009071)3.92233836
43cellular ketone body metabolic process (GO:0046950)3.90140913
44barbed-end actin filament capping (GO:0051016)3.84191606
45dicarboxylic acid biosynthetic process (GO:0043650)3.83916189
46regulation of fibrinolysis (GO:0051917)3.81531165
47protein-lipid complex remodeling (GO:0034368)3.80931150
48macromolecular complex remodeling (GO:0034367)3.80931150
49plasma lipoprotein particle remodeling (GO:0034369)3.80931150
50glutamate metabolic process (GO:0006536)3.80603718
51drug catabolic process (GO:0042737)3.79636461
52regulation of complement activation (GO:0030449)3.75956368
53plasma lipoprotein particle clearance (GO:0034381)3.75048884
54cholesterol efflux (GO:0033344)3.73941320
55amino-acid betaine metabolic process (GO:0006577)3.72307581
56mannose metabolic process (GO:0006013)3.71172577
57triglyceride homeostasis (GO:0070328)3.69463181
58acylglycerol homeostasis (GO:0055090)3.69463181
59cellular modified amino acid catabolic process (GO:0042219)3.69263091
60plasma lipoprotein particle assembly (GO:0034377)3.64105354
61intestinal cholesterol absorption (GO:0030299)3.63700784
62phospholipid homeostasis (GO:0055091)3.63199674
63alpha-amino acid catabolic process (GO:1901606)3.62736742
64positive regulation of lipid catabolic process (GO:0050996)3.61400788
65aromatic amino acid family metabolic process (GO:0009072)3.59584915
66bile acid and bile salt transport (GO:0015721)3.55679389
672-oxoglutarate metabolic process (GO:0006103)3.50070328
68angiotensin maturation (GO:0002003)3.48830746
69protein localization to endosome (GO:0036010)3.48036939
70short-chain fatty acid metabolic process (GO:0046459)3.46915409
71protein-lipid complex assembly (GO:0065005)3.45759668
72cellular amino acid catabolic process (GO:0009063)3.44846834
73tyrosine metabolic process (GO:0006570)3.42629162
74coenzyme catabolic process (GO:0009109)3.42537231
75positive regulation of fatty acid beta-oxidation (GO:0032000)3.41866164
76aspartate family amino acid catabolic process (GO:0009068)3.36277889
77acetyl-CoA metabolic process (GO:0006084)3.33841836
78ethanol oxidation (GO:0006069)3.33322570
79regulation of early endosome to late endosome transport (GO:2000641)3.31709120
80ketone body metabolic process (GO:1902224)3.31308765
81positive regulation of lipoprotein lipase activity (GO:0051006)3.31004932
82positive regulation of triglyceride lipase activity (GO:0061365)3.31004932
83flavonoid metabolic process (GO:0009812)3.29390559
84regulation of bile acid biosynthetic process (GO:0070857)3.27629254
85cholesterol homeostasis (GO:0042632)3.25181543
86glucose 6-phosphate metabolic process (GO:0051156)3.25180090
87positive regulation of Cdc42 GTPase activity (GO:0043089)3.25132458
88sterol homeostasis (GO:0055092)3.21073535
89regulation of fatty acid beta-oxidation (GO:0031998)3.19462497
90glycosphingolipid catabolic process (GO:0046479)3.18771050
91positive regulation of triglyceride metabolic process (GO:0090208)3.18292315
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.17783121
93fatty acid beta-oxidation (GO:0006635)3.17157141
94benzene-containing compound metabolic process (GO:0042537)3.16586992
95exogenous drug catabolic process (GO:0042738)3.15357995
96regulation of extracellular matrix disassembly (GO:0010715)3.13952633
97fatty acid oxidation (GO:0019395)3.12625159
98indolalkylamine metabolic process (GO:0006586)3.12126590
99cellular glucuronidation (GO:0052695)3.10274107
100carboxylic acid catabolic process (GO:0046395)3.08093138
101organic acid catabolic process (GO:0016054)3.08093138
102lipid oxidation (GO:0034440)3.06720361
103monocarboxylic acid catabolic process (GO:0072329)3.06313142
104lipoprotein metabolic process (GO:0042157)3.05860094
105fatty acid transmembrane transport (GO:1902001)3.05169929
106protein retention in ER lumen (GO:0006621)3.04998020
107plasma lipoprotein particle organization (GO:0071827)3.04712472
108fatty acid catabolic process (GO:0009062)3.04657201
109glycolipid catabolic process (GO:0019377)3.03011591
110serine family amino acid metabolic process (GO:0009069)3.02144323
111stress fiber assembly (GO:0043149)3.01111401
112positive regulation of fatty acid biosynthetic process (GO:0045723)3.00975042
113negative regulation of lipase activity (GO:0060192)2.99002408
114intestinal absorption (GO:0050892)2.98749803
115regulation of cholesterol metabolic process (GO:0090181)2.97999839
116protein-lipid complex subunit organization (GO:0071825)2.97891936
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97771983
118arginine metabolic process (GO:0006525)2.97210856
119pinocytosis (GO:0006907)2.96659868
120response to laminar fluid shear stress (GO:0034616)2.93567681
121adhesion of symbiont to host (GO:0044406)2.92282878
122regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.91605100
123low-density lipoprotein particle clearance (GO:0034383)2.87756921
124proline biosynthetic process (GO:0006561)2.84988077
125fructose metabolic process (GO:0006000)2.83760834
126embryonic process involved in female pregnancy (GO:0060136)2.80685516
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.80683190
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.80064522
129virion attachment to host cell (GO:0019062)2.79669247
130adhesion of symbiont to host cell (GO:0044650)2.79669247
131peptide catabolic process (GO:0043171)2.76992401
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76679448
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68184361
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64895995
135positive regulation of pseudopodium assembly (GO:0031274)2.62973441
136pentose-phosphate shunt (GO:0006098)2.62647491
137negative regulation of protein localization to plasma membrane (GO:1903077)2.58096249
138basement membrane organization (GO:0071711)2.56473050
139fat-soluble vitamin biosynthetic process (GO:0042362)2.56163850
140antigen processing and presentation of endogenous antigen (GO:0019883)2.53938903
141adherens junction assembly (GO:0034333)2.52155634
142positive regulation of receptor recycling (GO:0001921)2.51368191
143skin morphogenesis (GO:0043589)2.50914050
144epithelial cell-cell adhesion (GO:0090136)2.46980968
145negative regulation of cell size (GO:0045792)2.44367596
146regulation of cholesterol storage (GO:0010885)2.43660144
147cell-substrate adherens junction assembly (GO:0007045)2.43106628
148focal adhesion assembly (GO:0048041)2.43106628
149regulation of pseudopodium assembly (GO:0031272)2.41218122
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40461546
151ceramide catabolic process (GO:0046514)2.39107840
152regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38257458
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37922334
154negative regulation of fatty acid biosynthetic process (GO:0045717)2.37129525
155very-low-density lipoprotein particle assembly (GO:0034379)2.37004346
156NADPH regeneration (GO:0006740)2.36961958
157sphingolipid catabolic process (GO:0030149)2.36360974
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36052462
159modulation by symbiont of host cellular process (GO:0044068)2.35674059
160maternal placenta development (GO:0001893)2.34374199
161cell-substrate junction assembly (GO:0007044)2.33322629
162semaphorin-plexin signaling pathway (GO:0071526)2.32785378
163tricarboxylic acid metabolic process (GO:0072350)2.31583305
164negative regulation of viral release from host cell (GO:1902187)2.30684695
165detection of bacterium (GO:0016045)2.30677647
166membrane lipid catabolic process (GO:0046466)2.30372059
167fibril organization (GO:0097435)2.28704574
168endocytic recycling (GO:0032456)2.28303087
169regulation of extracellular matrix organization (GO:1903053)2.26718791
170actin filament depolymerization (GO:0030042)2.26136654
171amyloid precursor protein catabolic process (GO:0042987)2.25075441
172regulation of cellular extravasation (GO:0002691)2.24447097
173oxaloacetate metabolic process (GO:0006107)2.23970075
174positive regulation of extracellular matrix organization (GO:1903055)2.23567204
175response to thyroid hormone (GO:0097066)2.23560284
176negative regulation of fatty acid transport (GO:2000192)2.23559072
177positive regulation of nuclease activity (GO:0032075)2.23449938
178cellular response to thyroid hormone stimulus (GO:0097067)2.23359828
179NIK/NF-kappaB signaling (GO:0038061)2.22927170
180detection of other organism (GO:0098543)2.22858336
181positive regulation by symbiont of host defense response (GO:0052509)2.22636742
182modulation by symbiont of host defense response (GO:0052031)2.22636742
183modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22636742
184modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22636742
185positive regulation by organism of defense response of other organism involved in symbiotic interact2.22636742
186modulation by symbiont of host immune response (GO:0052553)2.22636742
187hyaluronan catabolic process (GO:0030214)2.21309528
188apoptotic cell clearance (GO:0043277)2.20967911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.36235024
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.99699634
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.36780945
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.88098847
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.36200106
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.86189674
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.72129669
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.34167314
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.86021525
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63063673
11VDR_21846776_ChIP-Seq_THP-1_Human2.28414841
12MYC_22102868_ChIP-Seq_BL_Human1.92468820
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90443833
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90077761
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.87772746
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85799313
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84621193
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80830513
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80354119
20GATA1_22025678_ChIP-Seq_K562_Human1.73314252
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.72223469
22CLOCK_20551151_ChIP-Seq_293T_Human1.68613527
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58582007
24* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52571745
25* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50884059
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49920848
27* LXR_22292898_ChIP-Seq_THP-1_Human1.49869691
28VDR_24763502_ChIP-Seq_THP-1_Human1.43779086
29NCOR1_26117541_ChIP-Seq_K562_Human1.39397359
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.38765545
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.37995226
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37912654
33* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37264858
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35460077
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34659162
36MAF_26560356_Chip-Seq_TH1_Human1.32211793
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32058278
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29243811
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29005941
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28456287
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27841656
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27811801
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25737296
44DROSHA_22980978_ChIP-Seq_HELA_Human1.23839064
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23373398
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.23303850
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.23251371
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.22054740
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21971123
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21716380
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21622229
52ATF3_27146783_Chip-Seq_COLON_Human1.21102660
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21070549
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20852268
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20729028
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20049135
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19848336
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19791672
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18359970
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16792736
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15863211
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15372932
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15368885
64SPI1_23127762_ChIP-Seq_K562_Human1.14071751
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13357729
66ZNF263_19887448_ChIP-Seq_K562_Human1.13337351
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.11999016
68GATA1_19941826_ChIP-Seq_K562_Human1.11830874
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.11600061
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11310020
71UTX_26944678_Chip-Seq_JUKART_Human1.10378567
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10074075
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08539640
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.08161124
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07682822
76MAF_26560356_Chip-Seq_TH2_Human1.07568080
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07541007
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07263271
79* KDM2B_26808549_Chip-Seq_K562_Human1.06460319
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.04799202
81* KDM2B_26808549_Chip-Seq_DND41_Human1.04130409
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.02567288
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02505691
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02456225
85BCL6_27268052_Chip-Seq_Bcells_Human1.01740769
86* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01382094
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01349256
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98566079
89RACK7_27058665_Chip-Seq_MCF-7_Human0.97318977
90GATA2_19941826_ChIP-Seq_K562_Human0.96871654
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.96695420
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96327271
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96111884
94* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94464838
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.94170160
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91965105
97CREB1_26743006_Chip-Seq_LNCaP_Human0.90987115
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89335891
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85906504
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85689171
101TCF7_22412390_ChIP-Seq_EML_Mouse0.84490341
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84104512
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82349717
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81765510
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80543018
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80017995
107* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79363426
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78682664
109RARB_27405468_Chip-Seq_BRAIN_Mouse0.78271314
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78125620
111P68_20966046_ChIP-Seq_HELA_Human0.78027097
112CTCF_27219007_Chip-Seq_Bcells_Human0.76994261
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76902932
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.76650346
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.76650346
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76193343
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75955938
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.74659534
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74237220
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73434595
121SMC4_20622854_ChIP-Seq_HELA_Human0.73090975
122* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72838634
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71839439
124* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70858384
125RUNX_20019798_ChIP-Seq_JUKART_Human0.70808767
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70759705
127* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70516759
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70369060
129* GATA6_25053715_ChIP-Seq_YYC3_Human0.70354121
130GATA4_25053715_ChIP-Seq_YYC3_Human0.70263430
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70066836
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69906210
133BCOR_27268052_Chip-Seq_Bcells_Human0.68381508
134* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67579749
135MTF2_20144788_ChIP-Seq_MESCs_Mouse0.66481630
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.66031389
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.66010658
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65740239
139TP63_22573176_ChIP-Seq_HFKS_Human0.64913054
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64671358
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.64326106
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.63781595
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.63666232
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.62462716
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.62291099
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.62171388
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.62056097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.09870625
2MP0002139_abnormal_hepatobiliary_system6.89956805
3MP0005365_abnormal_bile_salt5.32115395
4MP0005085_abnormal_gallbladder_physiolo5.21613607
5MP0008875_abnormal_xenobiotic_pharmacok4.23832490
6MP0009840_abnormal_foam_cell3.71293283
7MP0003252_abnormal_bile_duct3.50479279
8MP0010329_abnormal_lipoprotein_level3.47076827
9MP0001666_abnormal_nutrient_absorption3.00827865
10MP0005083_abnormal_biliary_tract2.62178069
11MP0003806_abnormal_nucleotide_metabolis2.56551157
12MP0008260_abnormal_autophagy2.52564264
13MP0003191_abnormal_cellular_cholesterol2.50666260
14MP0005332_abnormal_amino_acid2.47407550
15MP0008438_abnormal_cutaneous_collagen2.34780569
16MP0002118_abnormal_lipid_homeostasis2.13183343
17MP0002877_abnormal_melanocyte_morpholog2.05859216
18MP0000609_abnormal_liver_physiology2.04375176
19MP0003566_abnormal_cell_adhesion2.04180580
20MP0005409_darkened_coat_color1.84386876
21MP0003195_calcinosis1.84095045
22MP0004019_abnormal_vitamin_homeostasis1.81792416
23MP0001849_ear_inflammation1.77563264
24MP0003868_abnormal_feces_composition1.75249600
25MP0003705_abnormal_hypodermis_morpholog1.75128587
26MP0000604_amyloidosis1.73386423
27MP0002796_impaired_skin_barrier1.64802152
28MP0003329_amyloid_beta_deposits1.61007294
29MP0004130_abnormal_muscle_cell1.58696298
30MP0003091_abnormal_cell_migration1.58030168
31MP0005058_abnormal_lysosome_morphology1.56905519
32MP0005319_abnormal_enzyme/_coenzyme1.56723761
33MP0009278_abnormal_bone_marrow1.56063671
34MP0002138_abnormal_hepatobiliary_system1.55287278
35MP0003453_abnormal_keratinocyte_physiol1.54970766
36MP0005584_abnormal_enzyme/coenzyme_acti1.54562818
37MP0000678_abnormal_parathyroid_gland1.47347793
38MP0008961_abnormal_basal_metabolism1.47020515
39MP0004272_abnormal_basement_membrane1.44773693
40MP0003656_abnormal_erythrocyte_physiolo1.41917816
41MP0009643_abnormal_urine_homeostasis1.37790859
42MP0000858_altered_metastatic_potential1.36168208
43MP0005257_abnormal_intraocular_pressure1.35740470
44MP0010352_gastrointestinal_tract_polyps1.35124238
45MP0002837_dystrophic_cardiac_calcinosis1.34770195
46MP0005451_abnormal_body_composition1.34195001
47MP0005076_abnormal_cell_differentiation1.33085592
48MP0010155_abnormal_intestine_physiology1.30266939
49MP0010234_abnormal_vibrissa_follicle1.28262155
50MP0003300_gastrointestinal_ulcer1.25779669
51MP0005670_abnormal_white_adipose1.22465377
52MP0003279_aneurysm1.21957394
53MP0005023_abnormal_wound_healing1.19337395
54MP0002822_catalepsy1.19060352
55MP0004233_abnormal_muscle_weight1.18137063
56MP0002998_abnormal_bone_remodeling1.17641589
57MP0001533_abnormal_skeleton_physiology1.16922242
58MP0005501_abnormal_skin_physiology1.15795579
59MP0009333_abnormal_splenocyte_physiolog1.10831191
60MP0005666_abnormal_adipose_tissue1.09980256
61MP0001958_emphysema1.09927497
62MP0002078_abnormal_glucose_homeostasis1.07824055
63MP0005275_abnormal_skin_tensile1.06830360
64MP0000343_altered_response_to1.06149000
65MP0005535_abnormal_body_temperature1.05659718
66MP0002419_abnormal_innate_immunity1.03183912
67MP0005397_hematopoietic_system_phenotyp1.02097791
68MP0001545_abnormal_hematopoietic_system1.02097791
69MP0004782_abnormal_surfactant_physiolog1.02014997
70MP0004185_abnormal_adipocyte_glucose1.00806139
71MP0000003_abnormal_adipose_tissue0.99909589
72MP0005025_abnormal_response_to0.99121520
73MP0006138_congestive_heart_failure0.98370345
74MP0000490_abnormal_crypts_of0.97370045
75MP0000598_abnormal_liver_morphology0.97342296
76MP0002971_abnormal_brown_adipose0.95447953
77MP0005448_abnormal_energy_balance0.95229836
78MP0003690_abnormal_glial_cell0.94704559
79MP0001764_abnormal_homeostasis0.93742219
80MP0005334_abnormal_fat_pad0.93434901
81MP0005636_abnormal_mineral_homeostasis0.92455289
82MP0002909_abnormal_adrenal_gland0.92339616
83MP0001756_abnormal_urination0.89300202
84MP0009642_abnormal_blood_homeostasis0.88332250
85MP0009764_decreased_sensitivity_to0.87245071
86MP0003172_abnormal_lysosome_physiology0.87140843
87MP0002896_abnormal_bone_mineralization0.85302078
88MP0002060_abnormal_skin_morphology0.85293310
89MP0003075_altered_response_to0.85096294
90MP0006082_CNS_inflammation0.84911578
91MP0002254_reproductive_system_inflammat0.84114369
92MP0003828_pulmonary_edema0.82536675
93MP0001915_intracranial_hemorrhage0.82477609
94MP0000249_abnormal_blood_vessel0.82220853
95MP0000767_abnormal_smooth_muscle0.82182537
96MP0009780_abnormal_chondrocyte_physiolo0.81787209
97MP0005330_cardiomyopathy0.81246530
98MP0009931_abnormal_skin_appearance0.81208618
99MP0009785_altered_susceptibility_to0.79481567
100MP0008874_decreased_physiological_sensi0.78602498
101MP0004859_abnormal_synaptic_plasticity0.78581425
102MP0001216_abnormal_epidermal_layer0.77742011
103MP0003724_increased_susceptibility_to0.75438242
104MP0001790_abnormal_immune_system0.74850810
105MP0005387_immune_system_phenotype0.74850810
106MP0009763_increased_sensitivity_to0.73888462
107MP0008469_abnormal_protein_level0.72488542
108MP0001845_abnormal_inflammatory_respons0.71098434
109MP0005375_adipose_tissue_phenotype0.70998312
110MP0003448_altered_tumor_morphology0.69561634
111MP0005000_abnormal_immune_tolerance0.68937861
112MP0005166_decreased_susceptibility_to0.68807199
113MP0005464_abnormal_platelet_physiology0.68731544
114MP0000685_abnormal_immune_system0.68680773
115MP0001765_abnormal_ion_homeostasis0.68012575
116MP0005621_abnormal_cell_physiology0.67836920
117MP0000462_abnormal_digestive_system0.67112410
118MP0008872_abnormal_physiological_respon0.66421163
119MP0000747_muscle_weakness0.66005672
120MP0002136_abnormal_kidney_physiology0.65327429
121MP0003953_abnormal_hormone_level0.64178574
122MP0004510_myositis0.63564482
123MP0005167_abnormal_blood-brain_barrier0.63446422
124MP0004264_abnormal_extraembryonic_tissu0.63398771
125MP0004858_abnormal_nervous_system0.58458973
126MP0003303_peritoneal_inflammation0.58354890
127MP0003633_abnormal_nervous_system0.58060914
128MP0003436_decreased_susceptibility_to0.57150662
129MP0004043_abnormal_pH_regulation0.56873284
130MP0006036_abnormal_mitochondrial_physio0.56625713
131MP0005220_abnormal_exocrine_pancreas0.56596961
132MP0000230_abnormal_systemic_arterial0.54489334
133MP0003638_abnormal_response/metabolism_0.54412839
134MP0002876_abnormal_thyroid_physiology0.54295202
135MP0009765_abnormal_xenobiotic_induced0.54230758
136MP0005266_abnormal_metabolism0.52525437
137MP0005647_abnormal_sex_gland0.52068501
138MP0005376_homeostasis/metabolism_phenot0.51220072
139MP0003183_abnormal_peptide_metabolism0.49927743
140MP0004147_increased_porphyrin_level0.49835038
141MP0010368_abnormal_lymphatic_system0.49770170
142MP0002269_muscular_atrophy0.49542891
143MP0002090_abnormal_vision0.47915960
144MP0002069_abnormal_eating/drinking_beha0.47787500
145MP0000639_abnormal_adrenal_gland0.47568368
146MP0002970_abnormal_white_adipose0.47300123
147MP0009115_abnormal_fat_cell0.46115301
148MP0000538_abnormal_urinary_bladder0.45918593
149MP0004947_skin_inflammation0.45305242
150MP0001661_extended_life_span0.44872892
151MP0003011_delayed_dark_adaptation0.42391642
152MP0000751_myopathy0.40923804
153MP0001663_abnormal_digestive_system0.40140425
154MP0004270_analgesia0.39736186
155MP0003631_nervous_system_phenotype0.39612172

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.82493650
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47170717
3Xanthomatosis (HP:0000991)5.31064849
4Intrahepatic cholestasis (HP:0001406)5.27254330
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.87072138
6Hypobetalipoproteinemia (HP:0003563)4.67814398
7Complement deficiency (HP:0004431)4.41335663
8Hyperlipoproteinemia (HP:0010980)4.30759135
9Prolonged partial thromboplastin time (HP:0003645)4.07574147
10Ketosis (HP:0001946)4.02558092
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91117161
12Hyperammonemia (HP:0001987)3.88127811
13Hypolipoproteinemia (HP:0010981)3.70738847
14Hyperglycinuria (HP:0003108)3.69916850
15Hyperglycinemia (HP:0002154)3.56280088
16Epidermoid cyst (HP:0200040)3.54669319
17Abnormality of serine family amino acid metabolism (HP:0010894)3.51745492
18Abnormality of glycine metabolism (HP:0010895)3.51745492
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.47133327
20Hypoalphalipoproteinemia (HP:0003233)3.41713521
21Hypoglycemic coma (HP:0001325)3.41711590
22Abnormality of the common coagulation pathway (HP:0010990)3.41067301
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35982425
24Ketoacidosis (HP:0001993)3.30764988
25Fat malabsorption (HP:0002630)3.22362486
26Abnormality of complement system (HP:0005339)3.17268883
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17069666
28Joint hemorrhage (HP:0005261)3.15155658
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14428323
30Protrusio acetabuli (HP:0003179)3.04712718
31Conjugated hyperbilirubinemia (HP:0002908)3.02677235
32Hypercholesterolemia (HP:0003124)3.02145357
33Abnormality of fatty-acid metabolism (HP:0004359)2.93628542
34Premature rupture of membranes (HP:0001788)2.91234083
35Vertebral compression fractures (HP:0002953)2.90809310
36Increased connective tissue (HP:0009025)2.83125626
37Hyperbilirubinemia (HP:0002904)2.82225476
38Abnormality of methionine metabolism (HP:0010901)2.80021152
39Myocardial infarction (HP:0001658)2.74322223
40Gout (HP:0001997)2.71038181
41Abnormality of purine metabolism (HP:0004352)2.70698513
42Systemic lupus erythematosus (HP:0002725)2.68901901
43Abnormality of glycolipid metabolism (HP:0010969)2.68704810
44Abnormality of liposaccharide metabolism (HP:0010968)2.68704810
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.68704810
46Eczematoid dermatitis (HP:0000976)2.68269940
47Skin nodule (HP:0200036)2.62347877
48Abnormality of the intrinsic pathway (HP:0010989)2.60988143
49Dysostosis multiplex (HP:0000943)2.60492503
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.57031066
51Upper limb amyotrophy (HP:0009129)2.55760824
52Distal upper limb amyotrophy (HP:0007149)2.55760824
53Loss of speech (HP:0002371)2.52965817
54Acanthocytosis (HP:0001927)2.52364094
55Thin bony cortex (HP:0002753)2.52314373
56Distal lower limb amyotrophy (HP:0008944)2.52266401
57Cholelithiasis (HP:0001081)2.47965989
58Abnormality of nucleobase metabolism (HP:0010932)2.46379338
59Late onset (HP:0003584)2.45812589
60Abnormal gallbladder morphology (HP:0012437)2.43011168
61Sensorimotor neuropathy (HP:0007141)2.42601409
62Hypoglycemic seizures (HP:0002173)2.40954531
63Cerebral aneurysm (HP:0004944)2.37171514
64Mitral stenosis (HP:0001718)2.33757718
65Delayed CNS myelination (HP:0002188)2.32532889
66Increased variability in muscle fiber diameter (HP:0003557)2.32247516
67Neonatal onset (HP:0003623)2.31053484
68Metabolic acidosis (HP:0001942)2.30652574
69Glomerulonephritis (HP:0000099)2.25013257
70Distal lower limb muscle weakness (HP:0009053)2.24966330
71Mucopolysacchariduria (HP:0008155)2.24154249
72Urinary glycosaminoglycan excretion (HP:0003541)2.24154249
73Hepatocellular carcinoma (HP:0001402)2.23052857
74Abnormality of skeletal muscle fiber size (HP:0012084)2.21933470
75Abnormality of proline metabolism (HP:0010907)2.21445766
76Hydroxyprolinuria (HP:0003080)2.21445766
77Global brain atrophy (HP:0002283)2.20679810
78Malnutrition (HP:0004395)2.19125692
79Neurofibrillary tangles (HP:0002185)2.17591803
80Cervical subluxation (HP:0003308)2.17050685
81Amyloidosis (HP:0011034)2.15445396
82Myopathic facies (HP:0002058)2.15080202
83Achilles tendon contracture (HP:0001771)2.14856950
84Steatorrhea (HP:0002570)2.13558149
85Abnormality of serum amino acid levels (HP:0003112)2.12961495
86Exercise-induced myalgia (HP:0003738)2.12833389
87Cerebral inclusion bodies (HP:0100314)2.10472440
88Abnormality of macrophages (HP:0004311)2.10165470
89Poikilocytosis (HP:0004447)2.08995677
90Hemorrhage of the eye (HP:0011885)2.08908282
91Hyperparathyroidism (HP:0000843)2.08672336
92Spinal rigidity (HP:0003306)2.08102398
93Mildly elevated creatine phosphokinase (HP:0008180)2.07795314
94Gingivitis (HP:0000230)2.07481872
95Spastic diplegia (HP:0001264)2.06959066
96Recurrent gram-negative bacterial infections (HP:0005420)2.05609540
97Irritability (HP:0000737)2.05305612
98Ileus (HP:0002595)2.04637710
99Status epilepticus (HP:0002133)2.04232582
100Segmental peripheral demyelination/remyelination (HP:0003481)2.04163905
101Flat acetabular roof (HP:0003180)2.03875239
102Esophageal varix (HP:0002040)2.03581736
103Dicarboxylic aciduria (HP:0003215)2.03257437
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03257437
105Abnormal gallbladder physiology (HP:0012438)1.99322939
106Cholecystitis (HP:0001082)1.99322939
107Nuclear cataract (HP:0100018)1.99158019
108Abnormality of pyrimidine metabolism (HP:0004353)1.97740988
109Hand muscle atrophy (HP:0009130)1.95715119
110Hyperinsulinemic hypoglycemia (HP:0000825)1.93755620
111Hyperacusis (HP:0010780)1.93385664
112Asymmetric septal hypertrophy (HP:0001670)1.93368964
113Increased IgE level (HP:0003212)1.92506878
114Atrophic scars (HP:0001075)1.92489201
115Spontaneous abortion (HP:0005268)1.91813998
116Increased cerebral lipofuscin (HP:0011813)1.89899829
117Reticulocytosis (HP:0001923)1.89189111
118Aneurysm (HP:0002617)1.89158899
119Hypertriglyceridemia (HP:0002155)1.87821211
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.87648074
121Osteolytic defects of the hand bones (HP:0009699)1.87648074
122Abnormality of the Achilles tendon (HP:0005109)1.87296466
123Abnormality of the gallbladder (HP:0005264)1.85351007
124Pancreatitis (HP:0001733)1.85019763
125Polycythemia (HP:0001901)1.84475618
126Increased purine levels (HP:0004368)1.84325670
127Hyperuricemia (HP:0002149)1.84325670
128Obstructive sleep apnea (HP:0002870)1.82868944
129Cellulitis (HP:0100658)1.81590309
130Fragile skin (HP:0001030)1.81124976
131Symptomatic seizures (HP:0011145)1.81013807
132Vascular calcification (HP:0004934)1.80601256
133Brushfield spots (HP:0001088)1.80270241
134Myoglobinuria (HP:0002913)1.80038598
135Hyperglycemia (HP:0003074)1.79291056
136Gingival bleeding (HP:0000225)1.79055386
137Axonal loss (HP:0003447)1.77714670
138Bone pain (HP:0002653)1.77629431
139Gastrointestinal dysmotility (HP:0002579)1.76815326
140Broad face (HP:0000283)1.76632515
141Alkalosis (HP:0001948)1.76418012
142J-shaped sella turcica (HP:0002680)1.76408498
143Blue sclerae (HP:0000592)1.75487415
144Dilatation of the ascending aorta (HP:0005111)1.74828795
145Back pain (HP:0003418)1.74247872
146Lethargy (HP:0001254)1.72291142
147Death in childhood (HP:0003819)1.71999014
148Disproportionate tall stature (HP:0001519)1.71712768
149Colitis (HP:0002583)1.70870788
150Lower limb amyotrophy (HP:0007210)1.69208682
151Nephritis (HP:0000123)1.69157578
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68631287
153Abnormality of polysaccharide metabolism (HP:0011012)1.68631287
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68631287
155Abdominal distention (HP:0003270)1.68353839
156Stroke (HP:0001297)1.68040287
157Wormian bones (HP:0002645)1.67471648
158Hypertensive crisis (HP:0100735)1.66783381
159Supranuclear gaze palsy (HP:0000605)1.66262249
160Atelectasis (HP:0100750)1.65606425
161Hypophosphatemia (HP:0002148)1.64734143
162Pathologic fracture (HP:0002756)1.63661192
163Vascular tortuosity (HP:0004948)1.62551952
164Neuronal loss in central nervous system (HP:0002529)1.61730406
165Emphysema (HP:0002097)1.60735178
166Type 1 muscle fiber predominance (HP:0003803)1.60247114
167Nonimmune hydrops fetalis (HP:0001790)1.59369810
168Slender build (HP:0001533)1.59200316
169Elevated alkaline phosphatase (HP:0003155)1.58876617
170Vacuolated lymphocytes (HP:0001922)1.58309632
171Arterial tortuosity (HP:0005116)1.57942082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.20014011
2ERN14.13739272
3PRPF4B3.59878945
4BCKDK3.36062054
5FGFR43.09993966
6MAP3K92.77962543
7PKN22.73745149
8SIK12.66633611
9SMG12.38175519
10RIPK12.09369086
11IRAK32.03057689
12KSR21.95456653
13TAOK31.73220290
14TESK11.72421818
15CDK121.71535106
16LMTK21.66772283
17TAOK21.62708331
18CAMKK11.62166813
19PTK61.61114976
20INSRR1.60418738
21MAP2K41.59287353
22MAP3K101.56800487
23EPHA21.53969688
24MAP3K31.50768709
25RET1.49222910
26GRK61.46567872
27NME21.45713463
28MAP3K71.45564553
29MAP3K111.41325338
30CAMK1D1.32907546
31DDR21.32627205
32MAP3K131.32116921
33DAPK21.30850083
34PRKG21.29913355
35EPHA41.29247691
36CDC42BPA1.28540616
37FRK1.27284388
38PAK41.21519840
39TESK21.21148899
40PDGFRA1.20288512
41NTRK11.20067943
42TAOK11.18096637
43PAK61.16961522
44FGFR21.16160927
45SIK31.14698961
46CAMK1G1.11824094
47SIK21.11168596
48EPHB11.08952071
49JAK21.07465226
50TTN1.05953135
51MAP3K21.05140174
52PRKD21.04459421
53JAK11.03778010
54SGK31.03196720
55MAP3K60.96415820
56STK380.95812549
57EEF2K0.95341158
58MST1R0.94261878
59MAPK110.92521815
60PDPK10.92407210
61MAP3K40.91976422
62PDK20.91437970
63PTK20.90898057
64TYK20.90573426
65BMX0.89154256
66PRKCH0.88663417
67ICK0.86393364
68MAP4K10.84764639
69EPHA30.84675391
70RPS6KA20.84254003
71ARAF0.84078971
72PHKG10.83422773
73PHKG20.83422773
74KSR10.83012039
75ZAP700.81207543
76FGFR30.80755887
77PDK10.79674061
78TYRO30.78396054
79PRKAA20.77842395
80MAP2K10.77205950
81MOS0.77082139
82EPHB20.77032560
83MET0.75357893
84PRKCZ0.73936857
85LATS10.73822430
86ERBB40.73342452
87MAP3K10.70824640
88TGFBR20.70265239
89TBK10.70116770
90MAP3K140.69527891
91MAP3K80.68780130
92PRKAA10.68479625
93NEK10.66299531
94PRKD30.64503592
95PAK30.64275398
96MINK10.64053730
97NTRK20.63414123
98BLK0.62582092
99MATK0.62544344
100PINK10.62300537
101MAPK120.61577640
102MAPKAPK30.58819229
103STK110.57752405
104PRKD10.56875567
105TRPM70.55942683
106PRKACG0.54121380
107ERBB20.53886910
108PDGFRB0.52580091
109NTRK30.52271138
110MAPK70.50020816
111FLT30.49552571
112MARK20.48981045
113FES0.48355518
114DYRK1B0.47598079
115MAPKAPK20.46696684
116RPS6KC10.46403488
117RPS6KL10.46403488
118LATS20.45091197
119HIPK20.44887389
120CSK0.44352633
121SGK4940.43411175
122SGK2230.43411175
123MAPK40.43230615
124CSF1R0.43011662
125ABL20.42812500
126ITK0.42508145
127CDK50.42309095
128JAK30.42207044
129MARK10.41928112
130MAP2K20.41596833
131DMPK0.40653214
132LRRK20.39828036
133SGK20.39540204
134RIPK40.38980697
135IRAK40.38919453
136PIK3CG0.38822191
137MTOR0.38435732
138PAK20.38018141
139FER0.38007218
140MAP2K30.37877596
141CDK90.36916311
142IRAK20.35501763
143CAMK40.35463574
144FGR0.35289271
145SCYL20.34786061

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.87882621
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.64191413
3Other glycan degradation_Homo sapiens_hsa005113.24722948
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16570900
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95647261
6Arginine biosynthesis_Homo sapiens_hsa002202.89754411
7Fatty acid degradation_Homo sapiens_hsa000712.48173578
8Tryptophan metabolism_Homo sapiens_hsa003802.47762353
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34717783
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25292274
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18866837
12Complement and coagulation cascades_Homo sapiens_hsa046102.10894263
13Butanoate metabolism_Homo sapiens_hsa006502.10538190
14PPAR signaling pathway_Homo sapiens_hsa033201.96264440
15Bile secretion_Homo sapiens_hsa049761.90617470
16Propanoate metabolism_Homo sapiens_hsa006401.86281656
17Fatty acid metabolism_Homo sapiens_hsa012121.81551423
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80433881
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79631677
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79041626
21Caffeine metabolism_Homo sapiens_hsa002321.74992788
22Peroxisome_Homo sapiens_hsa041461.64756934
23Fat digestion and absorption_Homo sapiens_hsa049751.64587081
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62625979
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54918291
26Acute myeloid leukemia_Homo sapiens_hsa052211.54475492
27Staphylococcus aureus infection_Homo sapiens_hsa051501.52173256
28Histidine metabolism_Homo sapiens_hsa003401.52089754
29beta-Alanine metabolism_Homo sapiens_hsa004101.50130837
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46199125
31Starch and sucrose metabolism_Homo sapiens_hsa005001.43156072
32ABC transporters_Homo sapiens_hsa020101.36163090
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30831579
34Pyruvate metabolism_Homo sapiens_hsa006201.30610767
35Chronic myeloid leukemia_Homo sapiens_hsa052201.30500622
36Selenocompound metabolism_Homo sapiens_hsa004501.29810361
37Chemical carcinogenesis_Homo sapiens_hsa052041.28647184
38Notch signaling pathway_Homo sapiens_hsa043301.27121056
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.20736675
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19527056
41Phenylalanine metabolism_Homo sapiens_hsa003601.16414426
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.14905653
43Sulfur metabolism_Homo sapiens_hsa009201.13417952
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12297616
45Bladder cancer_Homo sapiens_hsa052191.11544285
46Carbon metabolism_Homo sapiens_hsa012001.10161044
47VEGF signaling pathway_Homo sapiens_hsa043701.09666853
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09547921
49Osteoclast differentiation_Homo sapiens_hsa043801.08120692
50Hepatitis C_Homo sapiens_hsa051601.06177133
51Glycerolipid metabolism_Homo sapiens_hsa005611.03463216
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03140620
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02482641
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.02361097
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.02235090
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02156818
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01796920
58Lysine degradation_Homo sapiens_hsa003101.01605173
59Biosynthesis of amino acids_Homo sapiens_hsa012301.01170764
60Pancreatic cancer_Homo sapiens_hsa052121.00893941
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96155887
62Retinol metabolism_Homo sapiens_hsa008300.94288989
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92137450
64Amoebiasis_Homo sapiens_hsa051460.92073312
65Leishmaniasis_Homo sapiens_hsa051400.91338954
66Tyrosine metabolism_Homo sapiens_hsa003500.91132190
67Toxoplasmosis_Homo sapiens_hsa051450.88261490
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86872674
69Non-small cell lung cancer_Homo sapiens_hsa052230.86095782
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.85393132
71Renal cell carcinoma_Homo sapiens_hsa052110.85172815
72B cell receptor signaling pathway_Homo sapiens_hsa046620.84541061
73Pertussis_Homo sapiens_hsa051330.83416214
74Thyroid cancer_Homo sapiens_hsa052160.82752192
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.82719555
76Vibrio cholerae infection_Homo sapiens_hsa051100.81573488
77GnRH signaling pathway_Homo sapiens_hsa049120.79630453
78Folate biosynthesis_Homo sapiens_hsa007900.78105928
79Vitamin digestion and absorption_Homo sapiens_hsa049770.77908622
80Influenza A_Homo sapiens_hsa051640.77822107
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.77815717
82Tuberculosis_Homo sapiens_hsa051520.77181933
83Endometrial cancer_Homo sapiens_hsa052130.76216257
84Salmonella infection_Homo sapiens_hsa051320.75027420
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74921394
86TNF signaling pathway_Homo sapiens_hsa046680.74882254
87Arginine and proline metabolism_Homo sapiens_hsa003300.72865249
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71869034
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71822677
90Focal adhesion_Homo sapiens_hsa045100.71816692
91Fatty acid biosynthesis_Homo sapiens_hsa000610.71132851
92Shigellosis_Homo sapiens_hsa051310.68450164
93Insulin resistance_Homo sapiens_hsa049310.67670481
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67616368
95Endocytosis_Homo sapiens_hsa041440.66012030
96Sphingolipid metabolism_Homo sapiens_hsa006000.65186904
97Apoptosis_Homo sapiens_hsa042100.63931498
98Malaria_Homo sapiens_hsa051440.63791499
99Prolactin signaling pathway_Homo sapiens_hsa049170.63617744
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63347085
101Inositol phosphate metabolism_Homo sapiens_hsa005620.62215343
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61649245
103Hepatitis B_Homo sapiens_hsa051610.60893840
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.59880524
105Phagosome_Homo sapiens_hsa041450.58818327
106Fatty acid elongation_Homo sapiens_hsa000620.58630942
107HIF-1 signaling pathway_Homo sapiens_hsa040660.58549120
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58377489
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.57530702
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57090985
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.57008757
112Adherens junction_Homo sapiens_hsa045200.56412792
113Viral myocarditis_Homo sapiens_hsa054160.56181971
114Galactose metabolism_Homo sapiens_hsa000520.54997349
115Type II diabetes mellitus_Homo sapiens_hsa049300.53776375
116Proteoglycans in cancer_Homo sapiens_hsa052050.53634818
117ErbB signaling pathway_Homo sapiens_hsa040120.52196801
118Sulfur relay system_Homo sapiens_hsa041220.51661303
119Choline metabolism in cancer_Homo sapiens_hsa052310.50570369
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48675918
121Estrogen signaling pathway_Homo sapiens_hsa049150.47418145
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.46657570
123Prion diseases_Homo sapiens_hsa050200.45363305
124Steroid biosynthesis_Homo sapiens_hsa001000.44485862
125Pentose phosphate pathway_Homo sapiens_hsa000300.44339673
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42533178
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41977383
128Fructose and mannose metabolism_Homo sapiens_hsa000510.40374264
129Glucagon signaling pathway_Homo sapiens_hsa049220.40193195
130Vitamin B6 metabolism_Homo sapiens_hsa007500.39465183
131Insulin signaling pathway_Homo sapiens_hsa049100.38026648
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37260795
133AMPK signaling pathway_Homo sapiens_hsa041520.36239111
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36163447
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33705438
136Renin-angiotensin system_Homo sapiens_hsa046140.22369961
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21614225
138Thyroid hormone synthesis_Homo sapiens_hsa049180.20537647
139Insulin secretion_Homo sapiens_hsa049110.18617528
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18615157
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18354422
142Glutathione metabolism_Homo sapiens_hsa004800.17548898
143Mineral absorption_Homo sapiens_hsa049780.17103162
144Pancreatic secretion_Homo sapiens_hsa049720.16507463
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.15936225
146Lysosome_Homo sapiens_hsa041420.15795749
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.15532713
148Metabolic pathways_Homo sapiens_hsa011000.14472290
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14075361
150Salivary secretion_Homo sapiens_hsa049700.13680018
151mTOR signaling pathway_Homo sapiens_hsa041500.10672408
152Dorso-ventral axis formation_Homo sapiens_hsa043200.09803461
153Gastric acid secretion_Homo sapiens_hsa049710.09532304
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08604700
155Renin secretion_Homo sapiens_hsa049240.08553848
156Protein digestion and absorption_Homo sapiens_hsa049740.07324041

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