HECW1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.72684846
2vocalization behavior (GO:0071625)5.54821718
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54105421
4synaptic vesicle exocytosis (GO:0016079)5.50773617
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38078746
6protein localization to synapse (GO:0035418)5.33440614
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15088693
8glutamate secretion (GO:0014047)5.13847972
9synaptic vesicle maturation (GO:0016188)4.87601676
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84908325
11regulation of synaptic vesicle exocytosis (GO:2000300)4.83975515
12regulation of glutamate receptor signaling pathway (GO:1900449)4.78591907
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.69080418
14locomotory exploration behavior (GO:0035641)4.51832060
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.51440085
16layer formation in cerebral cortex (GO:0021819)4.50189102
17neurotransmitter-gated ion channel clustering (GO:0072578)4.36417274
18postsynaptic membrane organization (GO:0001941)4.36325147
19neuron recognition (GO:0008038)4.26712997
20presynaptic membrane assembly (GO:0097105)4.25344125
21regulation of synaptic vesicle transport (GO:1902803)4.23347015
22positive regulation of synapse maturation (GO:0090129)4.23321089
23pyrimidine nucleobase catabolic process (GO:0006208)4.22853630
24neuronal action potential propagation (GO:0019227)4.22505210
25exploration behavior (GO:0035640)4.17246318
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.16479725
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.12048946
28neurotransmitter secretion (GO:0007269)4.10558332
29regulation of synapse structural plasticity (GO:0051823)4.09590946
30glutamate receptor signaling pathway (GO:0007215)4.08326967
31cell migration in hindbrain (GO:0021535)4.03222061
32axonal fasciculation (GO:0007413)3.94190227
33synaptic transmission, glutamatergic (GO:0035249)3.90192486
34presynaptic membrane organization (GO:0097090)3.89571451
35neuron-neuron synaptic transmission (GO:0007270)3.87056150
36regulation of neuronal synaptic plasticity (GO:0048168)3.71614297
37dendritic spine morphogenesis (GO:0060997)3.71588204
38behavioral response to nicotine (GO:0035095)3.70051111
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69669520
40response to pheromone (GO:0019236)3.67921443
41dendrite morphogenesis (GO:0048813)3.65737996
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.61457782
43cerebellar granule cell differentiation (GO:0021707)3.61135718
44cerebellar Purkinje cell differentiation (GO:0021702)3.58757687
45nucleobase catabolic process (GO:0046113)3.56891251
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.56304156
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54672893
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.54463798
49proline transport (GO:0015824)3.53874163
50regulation of postsynaptic membrane potential (GO:0060078)3.51725634
51synapse assembly (GO:0007416)3.51250914
52synaptic vesicle endocytosis (GO:0048488)3.49792369
53positive regulation of membrane potential (GO:0045838)3.47148754
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.46359224
55regulation of synapse maturation (GO:0090128)3.46303897
56regulation of neurotransmitter secretion (GO:0046928)3.42361077
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41353866
58neuronal ion channel clustering (GO:0045161)3.40812365
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40738488
60negative regulation of microtubule polymerization (GO:0031115)3.40329493
61central nervous system projection neuron axonogenesis (GO:0021952)3.38955136
62gamma-aminobutyric acid transport (GO:0015812)3.38254907
63auditory behavior (GO:0031223)3.33453493
64neurotransmitter transport (GO:0006836)3.33389828
65serotonin metabolic process (GO:0042428)3.30671658
66membrane depolarization during action potential (GO:0086010)3.28478808
67response to histamine (GO:0034776)3.27890988
68regulation of dendritic spine morphogenesis (GO:0061001)3.25232020
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24285466
70positive regulation of synapse assembly (GO:0051965)3.24263739
71response to auditory stimulus (GO:0010996)3.22587049
72innervation (GO:0060384)3.21923637
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21518672
74primary amino compound metabolic process (GO:1901160)3.21451694
75positive regulation of dendritic spine development (GO:0060999)3.20715240
76cellular potassium ion homeostasis (GO:0030007)3.18799715
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18180943
78long-term memory (GO:0007616)3.18017631
79membrane depolarization (GO:0051899)3.17365218
80membrane hyperpolarization (GO:0060081)3.16833157
81regulation of synaptic plasticity (GO:0048167)3.12497123
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11099064
83long-term synaptic potentiation (GO:0060291)3.10980641
84positive regulation of neurotransmitter secretion (GO:0001956)3.08963242
85transmission of nerve impulse (GO:0019226)3.08453484
86negative regulation of dendrite development (GO:2000171)3.08052727
87regulation of neurotransmitter transport (GO:0051588)3.07371699
88activation of protein kinase A activity (GO:0034199)3.07186392
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06931453
90startle response (GO:0001964)3.06083785
91C4-dicarboxylate transport (GO:0015740)3.05514212
92negative regulation of dendrite morphogenesis (GO:0050774)3.05342865
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.04904449
94central nervous system neuron axonogenesis (GO:0021955)3.03551223
95regulation of vesicle fusion (GO:0031338)3.02822079
96mechanosensory behavior (GO:0007638)3.02551825
97cerebral cortex radially oriented cell migration (GO:0021799)3.02252975
98neuromuscular synaptic transmission (GO:0007274)3.00117195
99regulation of neurotransmitter levels (GO:0001505)2.99679389
100neuronal action potential (GO:0019228)2.98894253
101synapse organization (GO:0050808)2.98306372
102regulation of synapse assembly (GO:0051963)2.96903056
103regulation of respiratory system process (GO:0044065)2.96543904
104adult walking behavior (GO:0007628)2.95561706
105intraspecies interaction between organisms (GO:0051703)2.94875295
106social behavior (GO:0035176)2.94875295
107learning (GO:0007612)2.94499136
108regulation of dendritic spine development (GO:0060998)2.94416123
109organelle transport along microtubule (GO:0072384)2.93863518
110axon extension (GO:0048675)2.93796048
111synaptic transmission (GO:0007268)2.92574225
112establishment of mitochondrion localization (GO:0051654)2.91814110
113protein polyglutamylation (GO:0018095)2.90049288
114atrial cardiac muscle cell action potential (GO:0086014)2.83507791
115regulation of voltage-gated calcium channel activity (GO:1901385)2.81590032
116behavioral defense response (GO:0002209)2.81438477
117behavioral fear response (GO:0001662)2.81438477
118cochlea development (GO:0090102)2.79879645
119adult behavior (GO:0030534)2.72910219
120neurofilament cytoskeleton organization (GO:0060052)2.69726678
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69419336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95381657
2GBX2_23144817_ChIP-Seq_PC3_Human4.12812496
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01478914
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00028981
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84791581
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73575575
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68617414
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.58264433
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53619371
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53619371
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49902639
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46733652
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44956464
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35524440
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33791949
16TAF15_26573619_Chip-Seq_HEK293_Human2.33299858
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29790523
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29121904
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.24394993
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19084865
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18489385
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16654972
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16261907
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11546050
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.09788203
26DROSHA_22980978_ChIP-Seq_HELA_Human2.06513478
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00935235
28AR_21572438_ChIP-Seq_LNCaP_Human2.00368216
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96835820
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.95680896
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95562432
32SMAD4_21799915_ChIP-Seq_A2780_Human1.75989274
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75293330
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75215235
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71374273
36P300_19829295_ChIP-Seq_ESCs_Human1.65537818
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.64860479
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59083361
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57114870
40RNF2_27304074_Chip-Seq_NSC_Mouse1.56549942
41IGF1R_20145208_ChIP-Seq_DFB_Human1.50649188
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48172568
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.46808318
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46537621
45ZNF274_21170338_ChIP-Seq_K562_Hela1.45535913
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45347410
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45320655
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44705203
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.39814250
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39544393
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37921721
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37345490
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.36991618
54AR_25329375_ChIP-Seq_VCAP_Human1.36837038
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36263809
56VDR_22108803_ChIP-Seq_LS180_Human1.34035536
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.32844391
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32831806
59* STAT3_23295773_ChIP-Seq_U87_Human1.30294659
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28215957
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26527374
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.25550629
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24202848
64FUS_26573619_Chip-Seq_HEK293_Human1.23953265
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.21646952
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.20926075
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20523843
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18772293
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.18387266
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18341560
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18144307
72CBP_20019798_ChIP-Seq_JUKART_Human1.18144307
73AHR_22903824_ChIP-Seq_MCF-7_Human1.17454662
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16603127
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16168680
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16168680
77EWS_26573619_Chip-Seq_HEK293_Human1.16075427
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.15076504
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14607710
80TCF4_23295773_ChIP-Seq_U87_Human1.14495446
81AR_19668381_ChIP-Seq_PC3_Human1.14191926
82* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12474943
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12107864
84ER_23166858_ChIP-Seq_MCF-7_Human1.11148167
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.09814319
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07867433
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07584541
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.06902013
89RUNX2_22187159_ChIP-Seq_PCA_Human1.06846668
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06231827
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05900027
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04442669
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03498608
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.03028923
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02870335
96TP53_22573176_ChIP-Seq_HFKS_Human1.02863465
97* JUN_21703547_ChIP-Seq_K562_Human1.02823977
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01563666
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.00929190
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99082783
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98966361
102FLI1_21867929_ChIP-Seq_TH2_Mouse0.97496994
103* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96095621
104TCF4_22108803_ChIP-Seq_LS180_Human0.95704116
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95686360
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95233562
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95197039
108TP53_18474530_ChIP-ChIP_U2OS_Human0.94697085
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94553134
110KDM2B_26808549_Chip-Seq_REH_Human0.93177185
111BCAT_22108803_ChIP-Seq_LS180_Human0.92682297
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91510367
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90974925
114SOX9_26525672_Chip-Seq_HEART_Mouse0.89526430
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.88646486
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88256878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.35087983
2MP0003880_abnormal_central_pattern4.96425153
3MP0004270_analgesia3.85285142
4MP0003635_abnormal_synaptic_transmissio3.81566243
5MP0001968_abnormal_touch/_nociception3.43040508
6MP0002063_abnormal_learning/memory/cond3.18676289
7MP0002734_abnormal_mechanical_nocicepti3.03240440
8MP0009745_abnormal_behavioral_response3.02785078
9MP0005423_abnormal_somatic_nervous3.00592328
10MP0002735_abnormal_chemical_nociception3.00511328
11MP0009046_muscle_twitch2.90741354
12MP0002064_seizures2.79367265
13MP0002736_abnormal_nociception_after2.72915578
14MP0002572_abnormal_emotion/affect_behav2.67907312
15MP0006276_abnormal_autonomic_nervous2.57418175
16MP0001984_abnormal_olfaction2.44334959
17MP0002272_abnormal_nervous_system2.42387071
18MP0000778_abnormal_nervous_system2.42018528
19MP0001486_abnormal_startle_reflex2.39764426
20MP0002184_abnormal_innervation2.28337931
21MP0002733_abnormal_thermal_nociception2.24933176
22MP0002067_abnormal_sensory_capabilities2.17719675
23MP0001440_abnormal_grooming_behavior2.09410545
24MP0001970_abnormal_pain_threshold2.08179489
25MP0002557_abnormal_social/conspecific_i1.90027605
26MP0005645_abnormal_hypothalamus_physiol1.83421205
27MP0003787_abnormal_imprinting1.82521308
28MP0004811_abnormal_neuron_physiology1.81690288
29MP0001501_abnormal_sleep_pattern1.80309311
30MP0004924_abnormal_behavior1.78732642
31MP0005386_behavior/neurological_phenoty1.78732642
32MP0008877_abnormal_DNA_methylation1.74233897
33MP0001188_hyperpigmentation1.70828208
34MP0003122_maternal_imprinting1.69021757
35MP0004858_abnormal_nervous_system1.67585456
36MP0000955_abnormal_spinal_cord1.66550197
37MP0009780_abnormal_chondrocyte_physiolo1.65494948
38MP0000569_abnormal_digit_pigmentation1.64816001
39MP0003879_abnormal_hair_cell1.62341641
40MP0003329_amyloid_beta_deposits1.58741625
41MP0002882_abnormal_neuron_morphology1.53721475
42MP0008569_lethality_at_weaning1.52941373
43MP0005646_abnormal_pituitary_gland1.52091155
44MP0002822_catalepsy1.41139843
45MP0001529_abnormal_vocalization1.41094649
46MP0001502_abnormal_circadian_rhythm1.40044156
47MP0002066_abnormal_motor_capabilities/c1.38180572
48MP0004147_increased_porphyrin_level1.36686933
49MP0002909_abnormal_adrenal_gland1.34663995
50MP0004742_abnormal_vestibular_system1.26189324
51MP0004142_abnormal_muscle_tone1.24823732
52MP0010386_abnormal_urinary_bladder1.24042214
53MP0001986_abnormal_taste_sensitivity1.20593748
54MP0002152_abnormal_brain_morphology1.20470797
55MP0005551_abnormal_eye_electrophysiolog1.20154188
56MP0001905_abnormal_dopamine_level1.18246431
57MP0005394_taste/olfaction_phenotype1.08229392
58MP0005499_abnormal_olfactory_system1.08229392
59MP0003633_abnormal_nervous_system1.04209770
60MP0004885_abnormal_endolymph1.02497852
61MP0000751_myopathy1.02060603
62MP0002752_abnormal_somatic_nervous1.01381789
63MP0002229_neurodegeneration1.00717822
64MP0000631_abnormal_neuroendocrine_gland1.00677312
65MP0004133_heterotaxia0.98742617
66MP0004043_abnormal_pH_regulation0.97752836
67MP0002234_abnormal_pharynx_morphology0.96310713
68MP0002653_abnormal_ependyma_morphology0.94371036
69MP0001963_abnormal_hearing_physiology0.92299321
70MP0003631_nervous_system_phenotype0.92070184
71MP0003121_genomic_imprinting0.89287994
72MP0002069_abnormal_eating/drinking_beha0.87233545
73MP0002876_abnormal_thyroid_physiology0.86465900
74MP0002102_abnormal_ear_morphology0.85255268
75MP0002638_abnormal_pupillary_reflex0.85132859
76MP0004145_abnormal_muscle_electrophysio0.84540987
77MP0004085_abnormal_heartbeat0.81255835
78MP0003861_abnormal_nervous_system0.79861575
79MP0008872_abnormal_physiological_respon0.78835638
80MP0002751_abnormal_autonomic_nervous0.77755917
81MP0000427_abnormal_hair_cycle0.73765580
82MP0003634_abnormal_glial_cell0.72462154
83MP0005409_darkened_coat_color0.72011477
84MP0002837_dystrophic_cardiac_calcinosis0.71228861
85MP0005187_abnormal_penis_morphology0.71142707
86MP0000026_abnormal_inner_ear0.69849464
87MP0005195_abnormal_posterior_eye0.69277783
88MP0008789_abnormal_olfactory_epithelium0.66616715
89MP0003698_abnormal_male_reproductive0.66606639
90MP0003137_abnormal_impulse_conducting0.66076933
91MP0003119_abnormal_digestive_system0.66042432
92MP0004215_abnormal_myocardial_fiber0.66003850
93MP0003890_abnormal_embryonic-extraembry0.65617089
94MP0001348_abnormal_lacrimal_gland0.65532156
95MP0001299_abnormal_eye_distance/0.64688556
96MP0001177_atelectasis0.64057352
97MP0006072_abnormal_retinal_apoptosis0.63461204
98MP0002090_abnormal_vision0.63098928
99MP0000049_abnormal_middle_ear0.63000124
100MP0008874_decreased_physiological_sensi0.62972895
101MP0003938_abnormal_ear_development0.62501199
102MP0001485_abnormal_pinna_reflex0.61515298
103MP0004233_abnormal_muscle_weight0.61449865
104MP0003123_paternal_imprinting0.60336659
105MP0001664_abnormal_digestion0.60082669
106MP0003632_abnormal_nervous_system0.59799589
107MP0006292_abnormal_olfactory_placode0.59205782
108MP0002160_abnormal_reproductive_system0.59035417
109MP0000604_amyloidosis0.58948416
110MP0001943_abnormal_respiration0.58179250
111MP0005535_abnormal_body_temperature0.57837551
112MP0010770_preweaning_lethality0.57628227
113MP0002082_postnatal_lethality0.57628227
114MP0003646_muscle_fatigue0.57582645
115MP0010769_abnormal_survival0.55881885
116MP0004484_altered_response_of0.55180085
117MP0005253_abnormal_eye_physiology0.53039722

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22913181
2Myokymia (HP:0002411)5.81304668
3Focal seizures (HP:0007359)5.52108672
4Epileptic encephalopathy (HP:0200134)5.27995482
5Febrile seizures (HP:0002373)4.93596233
6Atonic seizures (HP:0010819)4.85296856
7Absence seizures (HP:0002121)4.42336339
8Visual hallucinations (HP:0002367)4.41872272
9Progressive cerebellar ataxia (HP:0002073)4.26983034
10Hyperventilation (HP:0002883)4.09622905
11Dialeptic seizures (HP:0011146)3.95683381
12Broad-based gait (HP:0002136)3.78144679
13Generalized tonic-clonic seizures (HP:0002069)3.75648777
14Polyphagia (HP:0002591)3.68956115
15Supranuclear gaze palsy (HP:0000605)3.51294197
16Action tremor (HP:0002345)3.37952134
17Mutism (HP:0002300)3.31820012
18Excessive salivation (HP:0003781)3.31256026
19Drooling (HP:0002307)3.31256026
20Poor eye contact (HP:0000817)3.22852437
21Abnormal eating behavior (HP:0100738)3.21057929
22Amblyopia (HP:0000646)3.16941788
23Ankle clonus (HP:0011448)3.12283315
24Truncal ataxia (HP:0002078)3.01563983
25Limb dystonia (HP:0002451)2.96837522
26Gaze-evoked nystagmus (HP:0000640)2.96790043
27Termporal pattern (HP:0011008)2.91477575
28Insidious onset (HP:0003587)2.91477575
29Failure to thrive in infancy (HP:0001531)2.89757520
30Inability to walk (HP:0002540)2.84668449
31Abnormal social behavior (HP:0012433)2.84451241
32Impaired social interactions (HP:0000735)2.84451241
33Impaired vibration sensation in the lower limbs (HP:0002166)2.80141105
34Progressive inability to walk (HP:0002505)2.78476451
35Epileptiform EEG discharges (HP:0011182)2.77356139
36Pancreatic cysts (HP:0001737)2.77011357
37Abnormality of the corticospinal tract (HP:0002492)2.76657205
38Nephronophthisis (HP:0000090)2.72089753
39Urinary bladder sphincter dysfunction (HP:0002839)2.70640251
40Protruding tongue (HP:0010808)2.68361169
41EEG with generalized epileptiform discharges (HP:0011198)2.67008948
42Pancreatic fibrosis (HP:0100732)2.66155070
43Gait imbalance (HP:0002141)2.64626934
44Depression (HP:0000716)2.62039978
45Abnormality of midbrain morphology (HP:0002418)2.59687180
46Molar tooth sign on MRI (HP:0002419)2.59687180
47True hermaphroditism (HP:0010459)2.58565882
48Hemiparesis (HP:0001269)2.56646526
49Absent speech (HP:0001344)2.55985716
50Urinary urgency (HP:0000012)2.55929618
51Dysdiadochokinesis (HP:0002075)2.53366379
52Fetal akinesia sequence (HP:0001989)2.52204381
53Amyotrophic lateral sclerosis (HP:0007354)2.49740421
54Pheochromocytoma (HP:0002666)2.46255205
55Genetic anticipation (HP:0003743)2.44872249
56Congenital stationary night blindness (HP:0007642)2.41642961
57Hypsarrhythmia (HP:0002521)2.40492128
58Akinesia (HP:0002304)2.36470470
59Spastic gait (HP:0002064)2.36211863
60Abnormality of the lower motor neuron (HP:0002366)2.35086426
61Anxiety (HP:0000739)2.33617306
62Pachygyria (HP:0001302)2.33552607
63Inappropriate behavior (HP:0000719)2.31575637
64Stereotypic behavior (HP:0000733)2.30953464
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.29597842
66Hypoplasia of the brainstem (HP:0002365)2.29597842
67Abnormality of the renal medulla (HP:0100957)2.29128164
68Dysmetria (HP:0001310)2.28552659
69Abnormality of salivation (HP:0100755)2.25888464
70Torticollis (HP:0000473)2.25818798
71Impaired smooth pursuit (HP:0007772)2.23928315
72Sleep apnea (HP:0010535)2.21366555
73Papilledema (HP:0001085)2.20927226
74Specific learning disability (HP:0001328)2.20401802
75Scanning speech (HP:0002168)2.15553077
76Lissencephaly (HP:0001339)2.15070258
77Esotropia (HP:0000565)2.14832127
78Type II lissencephaly (HP:0007260)2.14675354
79Exotropia (HP:0000577)2.12343126
80Abnormality of binocular vision (HP:0011514)2.09956557
81Diplopia (HP:0000651)2.09956557
82Neuroendocrine neoplasm (HP:0100634)2.08979205
83Abnormal hair whorl (HP:0010721)2.08978599
84Lower limb muscle weakness (HP:0007340)2.08219998
85Spastic tetraplegia (HP:0002510)2.06275171
86Blue irides (HP:0000635)2.04707724
87Cerebral inclusion bodies (HP:0100314)2.03745320
88Focal dystonia (HP:0004373)2.02166109
89Bradykinesia (HP:0002067)2.01061481
90Neurofibrillary tangles (HP:0002185)2.00881821
91Hyperthyroidism (HP:0000836)1.99963975
92Postural instability (HP:0002172)1.99680877
93Agitation (HP:0000713)1.97489706
94Abnormality of ocular smooth pursuit (HP:0000617)1.96984258
95Cystic liver disease (HP:0006706)1.94644711
96Genital tract atresia (HP:0001827)1.93897101
97Ulnar claw (HP:0001178)1.93568466
98Medial flaring of the eyebrow (HP:0010747)1.92665754
99Aqueductal stenosis (HP:0002410)1.91829116
100Congenital primary aphakia (HP:0007707)1.91082671
101Retinal dysplasia (HP:0007973)1.90747117
102Chronic hepatic failure (HP:0100626)1.90190474
103Vaginal atresia (HP:0000148)1.89361015
104Pendular nystagmus (HP:0012043)1.88877914
105Craniofacial dystonia (HP:0012179)1.88646894
106Prolonged QT interval (HP:0001657)1.88350129
107Hypoventilation (HP:0002791)1.86469058
108Impaired vibratory sensation (HP:0002495)1.86422391
109Abnormal drinking behavior (HP:0030082)1.86273701
110Polydipsia (HP:0001959)1.86273701
111Generalized myoclonic seizures (HP:0002123)1.84786230
112Status epilepticus (HP:0002133)1.84538347
113Poor suck (HP:0002033)1.83761558
114Open mouth (HP:0000194)1.83712382
115Intellectual disability, severe (HP:0010864)1.83343324
116Hemiplegia (HP:0002301)1.82212989
117Abnormality of the labia minora (HP:0012880)1.81978532
118Nephrogenic diabetes insipidus (HP:0009806)1.81744052
119Attenuation of retinal blood vessels (HP:0007843)1.80516915
120Thyroid-stimulating hormone excess (HP:0002925)1.78714399
121Oligodactyly (hands) (HP:0001180)1.77618174
122Megalencephaly (HP:0001355)1.76976085
123Morphological abnormality of the pyramidal tract (HP:0002062)1.76691283
124Abnormality of the renal cortex (HP:0011035)1.76624531
125Generalized hypopigmentation of hair (HP:0011358)1.74878484
126Optic nerve hypoplasia (HP:0000609)1.74417274
127Incomplete penetrance (HP:0003829)1.73486105
128Widely spaced teeth (HP:0000687)1.71914585
129Cerebral hypomyelination (HP:0006808)1.71517896
130Abnormal rod and cone electroretinograms (HP:0008323)1.70151429
131Dyskinesia (HP:0100660)1.69093277
132Hypoplasia of the corpus callosum (HP:0002079)1.68441209
133Abnormal EKG (HP:0003115)1.64888369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.19400867
2CASK3.92700504
3NTRK33.77734926
4MAP3K93.62869852
5MAP3K43.14958688
6MAP2K73.01304164
7EPHA42.83242638
8MINK12.82394017
9MAP3K122.67677631
10FRK2.42819720
11DAPK22.37139055
12NTRK22.26241841
13MAP2K42.15996659
14MAP4K22.14970012
15MAPK132.13142254
16PAK62.04131221
17PINK11.74165550
18KSR11.69324399
19PLK21.59259565
20TNIK1.55399472
21CCNB11.53902641
22SIK21.53494597
23PHKG21.52262888
24PHKG11.52262888
25CDK191.49813487
26DAPK11.48278120
27PNCK1.41877742
28CDK51.39801664
29SIK31.36639475
30ADRBK21.33412330
31PRPF4B1.27178893
32DYRK21.25582267
33LATS21.25000953
34KSR21.22803200
35GRK51.21544563
36CAMKK11.20945697
37NTRK11.19435604
38RIPK41.17453457
39ERBB31.13605830
40CAMKK21.10038727
41PRKCG1.09144515
42WNK41.07017415
43INSRR1.06592826
44UHMK11.03139742
45BMPR1B0.95598325
46BCR0.93930910
47SGK2230.92082821
48SGK4940.92082821
49CDK180.91133708
50CAMK2A0.90426029
51CSNK1G20.89615256
52AKT30.86955038
53TRIM280.86943991
54CDK140.85007852
55CAMK40.83607166
56SGK20.83602392
57CDK150.82867341
58DYRK1A0.82748639
59OXSR10.76455511
60CSNK1G10.76201387
61MARK20.75969427
62WNK30.75966965
63RET0.75745155
64GRK10.74699048
65CDK11A0.70580994
66ZAK0.70056556
67PAK30.69628530
68MAP3K20.69333025
69CAMK2B0.67873825
70STK380.67846352
71MAP3K60.67814261
72BMPR20.66979383
73STK110.64446597
74TYRO30.64284058
75NUAK10.64204666
76PRKCH0.62773605
77PRKCZ0.60465364
78STK390.60313854
79PRKD30.60078558
80FES0.59827630
81PRKCE0.57230439
82ARAF0.56608851
83FGFR20.55233019
84MAPK120.54646092
85LMTK20.54592048
86NME10.54385901
87SGK10.53567293
88EPHB20.53394065
89CAMK10.51340602
90SGK30.49099531
91RPS6KA20.49058720
92CSNK1D0.48229533
93PKN10.48181038
94ACVR1B0.47036338
95FER0.46544429
96PRKACA0.44542506
97CSNK1G30.43811185
98TAOK10.43754370
99CSNK1A10.43522289
100TAOK30.42216908
101CSNK1E0.40994367
102MKNK20.40043664
103WNK10.39865102
104ADRBK10.39852321
105LIMK10.39814703
106CAMK1G0.39398013
107BRAF0.38690910
108MAP2K10.37521825
109MAP2K60.36324697
110CDK30.35645377
111PTK2B0.35047484
112GRK70.34884503
113FYN0.34712944
114TLK10.34415919
115PRKCA0.34209383
116RPS6KA30.33819053
117CSNK1A1L0.33248978
118CAMK2D0.32725101
119RAF10.31156062
120PRKAA10.31106395
121CAMK1D0.30428856
122PRKCB0.29589114
123PDK10.29074574
124CAMK2G0.28762428
125MAPK100.28679972
126PRKG10.28102040
127TNK20.27639351
128FGR0.27564174

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02916613
2Synaptic vesicle cycle_Homo sapiens_hsa047213.64479671
3Olfactory transduction_Homo sapiens_hsa047402.81439107
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78099582
5GABAergic synapse_Homo sapiens_hsa047272.62594209
6Circadian entrainment_Homo sapiens_hsa047132.58054409
7Morphine addiction_Homo sapiens_hsa050322.49446058
8Glutamatergic synapse_Homo sapiens_hsa047242.46278773
9Long-term potentiation_Homo sapiens_hsa047202.41645404
10Dopaminergic synapse_Homo sapiens_hsa047282.22909795
11Amphetamine addiction_Homo sapiens_hsa050312.16789301
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08660509
13Taste transduction_Homo sapiens_hsa047421.99126021
14Salivary secretion_Homo sapiens_hsa049701.96669245
15Insulin secretion_Homo sapiens_hsa049111.93013593
16Cholinergic synapse_Homo sapiens_hsa047251.92135375
17Collecting duct acid secretion_Homo sapiens_hsa049661.89445623
18Serotonergic synapse_Homo sapiens_hsa047261.84543860
19Renin secretion_Homo sapiens_hsa049241.73277786
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65875297
21Long-term depression_Homo sapiens_hsa047301.63812679
22Axon guidance_Homo sapiens_hsa043601.62810097
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60778902
24Oxytocin signaling pathway_Homo sapiens_hsa049211.59209116
25Gastric acid secretion_Homo sapiens_hsa049711.59142433
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58256006
27Calcium signaling pathway_Homo sapiens_hsa040201.43849104
28Gap junction_Homo sapiens_hsa045401.40874830
29Cocaine addiction_Homo sapiens_hsa050301.38986492
30GnRH signaling pathway_Homo sapiens_hsa049121.37302914
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36936208
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35301444
33Phototransduction_Homo sapiens_hsa047441.35031836
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28293691
35Butanoate metabolism_Homo sapiens_hsa006501.21726115
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18919323
37ErbB signaling pathway_Homo sapiens_hsa040121.18751426
38Vibrio cholerae infection_Homo sapiens_hsa051101.15882648
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14971926
40Cardiac muscle contraction_Homo sapiens_hsa042601.10218818
41cAMP signaling pathway_Homo sapiens_hsa040241.09413232
42Glioma_Homo sapiens_hsa052141.07314655
43Estrogen signaling pathway_Homo sapiens_hsa049151.06864657
44Type II diabetes mellitus_Homo sapiens_hsa049301.05227617
45Linoleic acid metabolism_Homo sapiens_hsa005911.00236865
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99778600
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99502091
48Melanogenesis_Homo sapiens_hsa049160.97731631
49Ether lipid metabolism_Homo sapiens_hsa005650.96432375
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95838531
51Nitrogen metabolism_Homo sapiens_hsa009100.95663022
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95476845
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93577121
54Oocyte meiosis_Homo sapiens_hsa041140.91368857
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85195306
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.82322273
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79408179
58MAPK signaling pathway_Homo sapiens_hsa040100.78155434
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75202846
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73132655
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.71881915
62Endometrial cancer_Homo sapiens_hsa052130.69332137
63Dorso-ventral axis formation_Homo sapiens_hsa043200.67625498
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.67091711
65Alzheimers disease_Homo sapiens_hsa050100.66997958
66Choline metabolism in cancer_Homo sapiens_hsa052310.66119861
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65495379
68Dilated cardiomyopathy_Homo sapiens_hsa054140.65358594
69Ras signaling pathway_Homo sapiens_hsa040140.65133227
70Ovarian steroidogenesis_Homo sapiens_hsa049130.62987941
71VEGF signaling pathway_Homo sapiens_hsa043700.61770543
72Colorectal cancer_Homo sapiens_hsa052100.61309708
73Oxidative phosphorylation_Homo sapiens_hsa001900.60545253
74Pancreatic secretion_Homo sapiens_hsa049720.60192672
75Alcoholism_Homo sapiens_hsa050340.58582307
76Regulation of autophagy_Homo sapiens_hsa041400.57912313
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57425132
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56045338
79Circadian rhythm_Homo sapiens_hsa047100.55724807
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.55310642
81Renal cell carcinoma_Homo sapiens_hsa052110.54418862
82Wnt signaling pathway_Homo sapiens_hsa043100.53998619
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53754901
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51154145
85Thyroid hormone synthesis_Homo sapiens_hsa049180.50035108
86Glucagon signaling pathway_Homo sapiens_hsa049220.49737454
87Selenocompound metabolism_Homo sapiens_hsa004500.49704062
88Rap1 signaling pathway_Homo sapiens_hsa040150.49563088
89Bile secretion_Homo sapiens_hsa049760.49337059
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48780636
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48278392
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48142776
93ABC transporters_Homo sapiens_hsa020100.48013724
94mTOR signaling pathway_Homo sapiens_hsa041500.46581538
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45563797
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44442506
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44407791
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44151985
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44115782
100Insulin signaling pathway_Homo sapiens_hsa049100.43999612
101Fatty acid biosynthesis_Homo sapiens_hsa000610.43914708
102Inositol phosphate metabolism_Homo sapiens_hsa005620.43873409
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42837740
104Parkinsons disease_Homo sapiens_hsa050120.41851448
105Phagosome_Homo sapiens_hsa041450.41823408
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41689292
107Hedgehog signaling pathway_Homo sapiens_hsa043400.39311225
108beta-Alanine metabolism_Homo sapiens_hsa004100.39257886
109Tryptophan metabolism_Homo sapiens_hsa003800.39116055
110Endocytosis_Homo sapiens_hsa041440.39066451
111Prion diseases_Homo sapiens_hsa050200.38448230
112Basal transcription factors_Homo sapiens_hsa030220.38318393
113Hippo signaling pathway_Homo sapiens_hsa043900.37595179
114Steroid biosynthesis_Homo sapiens_hsa001000.37001763
115Melanoma_Homo sapiens_hsa052180.33749151
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33446791
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33324571
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32371513
119Huntingtons disease_Homo sapiens_hsa050160.31837549
120Non-small cell lung cancer_Homo sapiens_hsa052230.31630611
121Rheumatoid arthritis_Homo sapiens_hsa053230.31137062
122Protein export_Homo sapiens_hsa030600.30146545
123Vitamin B6 metabolism_Homo sapiens_hsa007500.29187996
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.24797998

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