HECW2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphangiogenesis (GO:0001946)4.78864094
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.78749780
3locomotory exploration behavior (GO:0035641)4.75875938
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75721474
5synaptic vesicle maturation (GO:0016188)4.70655528
6vocalization behavior (GO:0071625)4.69055153
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46315411
8neuron cell-cell adhesion (GO:0007158)4.43213124
9blood vessel maturation (GO:0001955)4.39492848
10glutamate secretion (GO:0014047)4.34731281
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.33157052
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30703402
13synaptic vesicle exocytosis (GO:0016079)4.23896898
14regulation of glutamate receptor signaling pathway (GO:1900449)4.06149848
15regulation of synaptic vesicle exocytosis (GO:2000300)4.02846087
16neuronal action potential propagation (GO:0019227)3.93025550
17protein localization to synapse (GO:0035418)3.91305779
18endothelium development (GO:0003158)3.90697422
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.90171268
20neurotransmitter-gated ion channel clustering (GO:0072578)3.80247083
21layer formation in cerebral cortex (GO:0021819)3.75481763
22neuron recognition (GO:0008038)3.69964552
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69889950
24synaptic transmission, glutamatergic (GO:0035249)3.63005267
25exploration behavior (GO:0035640)3.62583770
26neuron-neuron synaptic transmission (GO:0007270)3.59831314
27glutamate receptor signaling pathway (GO:0007215)3.59443769
28cerebellar granule cell differentiation (GO:0021707)3.56887904
29axonal fasciculation (GO:0007413)3.55710892
30artery development (GO:0060840)3.54205896
31dendritic spine morphogenesis (GO:0060997)3.53997155
32regulation of synapse structural plasticity (GO:0051823)3.52521235
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51963237
34regulation of synaptic vesicle transport (GO:1902803)3.51708270
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.49873014
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49690862
37presynaptic membrane assembly (GO:0097105)3.47562252
38neurotransmitter secretion (GO:0007269)3.43387366
39regulation of neuronal synaptic plasticity (GO:0048168)3.43303936
40positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.43123552
41gamma-aminobutyric acid transport (GO:0015812)3.39419646
42presynaptic membrane organization (GO:0097090)3.39312212
43retina vasculature morphogenesis in camera-type eye (GO:0061299)3.35508284
44regulation of dendritic spine morphogenesis (GO:0061001)3.34994748
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34241398
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31415392
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.25921470
48regulation of postsynaptic membrane potential (GO:0060078)3.22881960
49long-term memory (GO:0007616)3.19396450
50dendrite morphogenesis (GO:0048813)3.15196585
51regulation of sarcomere organization (GO:0060297)3.14743228
52auditory behavior (GO:0031223)3.13176455
53regulation of voltage-gated calcium channel activity (GO:1901385)3.12714200
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08656778
55positive regulation of membrane potential (GO:0045838)3.07378317
56long-term synaptic potentiation (GO:0060291)3.05722704
57cellular potassium ion homeostasis (GO:0030007)3.05701356
58transmission of nerve impulse (GO:0019226)3.05262792
59cerebellar Purkinje cell differentiation (GO:0021702)3.04309552
60long term synaptic depression (GO:0060292)3.03749601
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02169344
62positive regulation of synapse maturation (GO:0090129)3.02092410
63regulation of synaptic plasticity (GO:0048167)3.00313234
64activation of protein kinase A activity (GO:0034199)2.99325742
65regulation of neurotransmitter secretion (GO:0046928)2.94693899
66regulation of synaptic transmission, glutamatergic (GO:0051966)2.93235554
67regulation of dendritic spine development (GO:0060998)2.92713711
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91020535
69postsynaptic membrane organization (GO:0001941)2.89216143
70regulation of axon guidance (GO:1902667)2.88133818
71neuromuscular process controlling balance (GO:0050885)2.86991089
72regulation of axon extension involved in axon guidance (GO:0048841)2.86399771
73proline transport (GO:0015824)2.86007923
74regulation of endothelial cell differentiation (GO:0045601)2.82449053
75central nervous system projection neuron axonogenesis (GO:0021952)2.81746122
76membrane depolarization (GO:0051899)2.81015324
77regulation of synapse maturation (GO:0090128)2.80940632
78neuromuscular process controlling posture (GO:0050884)2.80777769
79positive regulation of cardiac muscle cell differentiation (GO:2000727)2.79937793
80atrial cardiac muscle cell action potential (GO:0086014)2.79934128
81prepulse inhibition (GO:0060134)2.79431321
82negative regulation of neurotransmitter transport (GO:0051589)2.78798576
83neurotransmitter transport (GO:0006836)2.77900198
84establishment of nucleus localization (GO:0040023)2.77823557
85synapse assembly (GO:0007416)2.77151083
86mechanosensory behavior (GO:0007638)2.76929427
87negative regulation of axon guidance (GO:1902668)2.76872140
88positive regulation of neurotransmitter secretion (GO:0001956)2.76706025
89membrane hyperpolarization (GO:0060081)2.76160289
90regulation of neurotransmitter transport (GO:0051588)2.76109725
91sprouting angiogenesis (GO:0002040)2.75622597
92positive regulation of endothelial cell differentiation (GO:0045603)2.75561372
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74837110
94behavioral response to cocaine (GO:0048148)2.74092389
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73862758
96neuronal ion channel clustering (GO:0045161)2.73743071
97central nervous system neuron axonogenesis (GO:0021955)2.73300367
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.71479466
99dendritic spine organization (GO:0097061)2.70073317
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69188805
101synaptic vesicle endocytosis (GO:0048488)2.66149333
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65473506
103membrane depolarization during action potential (GO:0086010)2.64792502
104response to auditory stimulus (GO:0010996)2.64052703
105vesicle transport along microtubule (GO:0047496)2.64041797
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63819889
107positive regulation of neurotransmitter transport (GO:0051590)2.62981396
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62572043
109cell migration in hindbrain (GO:0021535)2.61630935
110neuromuscular process (GO:0050905)2.60321681
111cell communication by electrical coupling (GO:0010644)2.59858067
112central nervous system myelination (GO:0022010)2.59715535
113axon ensheathment in central nervous system (GO:0032291)2.59715535
114regulation of respiratory system process (GO:0044065)2.58360575
115response to histamine (GO:0034776)2.58270092
116membrane assembly (GO:0071709)2.57038887
117learning (GO:0007612)2.56582484
118regulation of neurotransmitter levels (GO:0001505)2.56337943
119synapse organization (GO:0050808)2.56232886
120adult walking behavior (GO:0007628)2.55901477
121endothelial cell differentiation (GO:0045446)2.55830964
122organelle transport along microtubule (GO:0072384)2.55170454
123glycine transport (GO:0015816)2.54495155
124positive regulation of cardiac muscle hypertrophy (GO:0010613)2.54400721
125positive regulation of muscle hypertrophy (GO:0014742)2.54400721
126positive regulation of synaptic transmission (GO:0050806)2.53663982
127cAMP catabolic process (GO:0006198)2.53554945
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48286382
129potassium ion import (GO:0010107)2.45177171
130regulation of synaptic transmission, GABAergic (GO:0032228)2.45142665
131renal tubule morphogenesis (GO:0061333)2.44028984
132Notch signaling involved in heart development (GO:0061314)2.37660324
133nerve growth factor signaling pathway (GO:0038180)2.36387879
134negative regulation of dendrite development (GO:2000171)2.33326753
135cochlea development (GO:0090102)2.31634682
136positive regulation of fibroblast migration (GO:0010763)2.31357492
137vascular endothelial growth factor signaling pathway (GO:0038084)2.29684326
138neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29129904
139regulation of vasculogenesis (GO:2001212)2.29122753
140negative regulation of blood vessel endothelial cell migration (GO:0043537)2.25074531
141regulation of cell communication by electrical coupling (GO:0010649)2.24859680
142lymph vessel development (GO:0001945)2.24712776
143detection of calcium ion (GO:0005513)2.24223244
144retinal cone cell development (GO:0046549)2.24019503
145wound healing, spreading of epidermal cells (GO:0035313)2.23129893
146cyclic nucleotide catabolic process (GO:0009214)2.22977560
147serotonin metabolic process (GO:0042428)2.21995040
148neuron remodeling (GO:0016322)2.21107901
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.20766827
150neuron maturation (GO:0042551)2.18586599
151C4-dicarboxylate transport (GO:0015740)2.18563075
152regulation of cardiac muscle cell contraction (GO:0086004)2.17396656
153positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.17118035
154nucleus localization (GO:0051647)2.16177866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11766552
2GBX2_23144817_ChIP-Seq_PC3_Human3.60677017
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86244116
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84438181
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70974462
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52286755
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52286755
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41432041
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35130208
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.34392515
11DROSHA_22980978_ChIP-Seq_HELA_Human2.33049495
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29234483
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28024591
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27295007
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.20944131
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19860341
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.02491742
18REST_21632747_ChIP-Seq_MESCs_Mouse2.01350016
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00715690
20TAF15_26573619_Chip-Seq_HEK293_Human1.99018620
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96413215
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.95595669
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.92431135
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91464565
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.87173865
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85365694
27AR_21572438_ChIP-Seq_LNCaP_Human1.82565339
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74298123
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.73278876
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72207331
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70682937
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.65760140
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64272127
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62446801
35P300_19829295_ChIP-Seq_ESCs_Human1.53232563
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50255246
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.49818905
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49635649
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48125351
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47520962
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.47375392
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45999732
43VDR_22108803_ChIP-Seq_LS180_Human1.44164866
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43366299
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.40272063
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40142941
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39769336
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38230255
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36684580
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36438941
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36293924
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35446954
53* STAT3_23295773_ChIP-Seq_U87_Human1.33815739
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.32666597
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31496317
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31234473
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30898776
58* AHR_22903824_ChIP-Seq_MCF-7_Human1.29966719
59* ARNT_22903824_ChIP-Seq_MCF-7_Human1.28553183
60* FLI1_27457419_Chip-Seq_LIVER_Mouse1.28488749
61AR_25329375_ChIP-Seq_VCAP_Human1.28047201
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27850127
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.27766460
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26380363
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25935070
66TP53_16413492_ChIP-PET_HCT116_Human1.25399466
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24230324
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.23758932
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22542524
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21327490
71* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20750951
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20447966
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19554358
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19554358
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18628733
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18547150
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.17857178
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16717800
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16011255
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16011255
81AR_19668381_ChIP-Seq_PC3_Human1.15803672
82* TCF4_23295773_ChIP-Seq_U87_Human1.15394058
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15198899
84EWS_26573619_Chip-Seq_HEK293_Human1.14805449
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14103370
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.13438512
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12682614
88FUS_26573619_Chip-Seq_HEK293_Human1.12456885
89CJUN_26792858_Chip-Seq_BT549_Human1.11870953
90* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11611922
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10987983
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10643147
93KDM2B_26808549_Chip-Seq_REH_Human1.10064838
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09921349
95ZNF274_21170338_ChIP-Seq_K562_Hela1.09765112
96* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09455158
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09016409
98* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08310483
99CBP_20019798_ChIP-Seq_JUKART_Human1.08234785
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08234785
101* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07441254
102IGF1R_20145208_ChIP-Seq_DFB_Human1.06623033
103TP53_18474530_ChIP-ChIP_U2OS_Human1.05267720
104RNF2_27304074_Chip-Seq_NSC_Mouse1.04011598
105* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03907840
106* BCAT_22108803_ChIP-Seq_LS180_Human1.02961413
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.02804816
108* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02700901
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01457709
110* RXR_22108803_ChIP-Seq_LS180_Human1.01369220
111ER_23166858_ChIP-Seq_MCF-7_Human1.01016197
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.99687030
113* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99127277
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95992972
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92719696
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91203015
117* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90790127
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87975962
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87499841
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.87270284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53497080
2MP0003880_abnormal_central_pattern4.63295140
3MP0003635_abnormal_synaptic_transmissio3.69861087
4MP0004270_analgesia3.64082036
5MP0009745_abnormal_behavioral_response3.11773877
6MP0002063_abnormal_learning/memory/cond3.02825535
7MP0009046_muscle_twitch3.01830586
8MP0002064_seizures2.78928526
9MP0001486_abnormal_startle_reflex2.67406206
10MP0002572_abnormal_emotion/affect_behav2.52640742
11MP0002734_abnormal_mechanical_nocicepti2.47263204
12MP0001968_abnormal_touch/_nociception2.42553525
13MP0002272_abnormal_nervous_system2.33687493
14MP0005423_abnormal_somatic_nervous2.28735560
15MP0009780_abnormal_chondrocyte_physiolo2.28649675
16MP0002822_catalepsy2.13757042
17MP0003787_abnormal_imprinting1.98883554
18MP0000778_abnormal_nervous_system1.96619786
19MP0001440_abnormal_grooming_behavior1.90008813
20MP0002067_abnormal_sensory_capabilities1.80827247
21MP0000751_myopathy1.78462000
22MP0000569_abnormal_digit_pigmentation1.78078288
23MP0001501_abnormal_sleep_pattern1.77322863
24MP0010368_abnormal_lymphatic_system1.75355251
25MP0002735_abnormal_chemical_nociception1.74884981
26MP0001970_abnormal_pain_threshold1.68418687
27MP0004272_abnormal_basement_membrane1.68005582
28MP0002557_abnormal_social/conspecific_i1.66610528
29MP0002736_abnormal_nociception_after1.66102309
30MP0002184_abnormal_innervation1.60372892
31MP0004924_abnormal_behavior1.60220493
32MP0005386_behavior/neurological_phenoty1.60220493
33MP0002733_abnormal_thermal_nociception1.57412639
34MP0008569_lethality_at_weaning1.55966526
35MP0005167_abnormal_blood-brain_barrier1.47094704
36MP0004885_abnormal_endolymph1.46864144
37MP0003279_aneurysm1.45987537
38MP0005623_abnormal_meninges_morphology1.44248919
39MP0004811_abnormal_neuron_physiology1.43010881
40MP0004215_abnormal_myocardial_fiber1.42504308
41MP0004145_abnormal_muscle_electrophysio1.41805625
42MP0001188_hyperpigmentation1.40557290
43MP0000767_abnormal_smooth_muscle1.39275382
44MP0006276_abnormal_autonomic_nervous1.37882968
45MP0005645_abnormal_hypothalamus_physiol1.37773315
46MP0003633_abnormal_nervous_system1.35153951
47MP0005646_abnormal_pituitary_gland1.34926125
48MP0002638_abnormal_pupillary_reflex1.33933336
49MP0000955_abnormal_spinal_cord1.33817140
50MP0005171_absent_coat_pigmentation1.33460193
51MP0002138_abnormal_hepatobiliary_system1.32686297
52MP0002066_abnormal_motor_capabilities/c1.27819314
53MP0001879_abnormal_lymphatic_vessel1.26923927
54MP0004085_abnormal_heartbeat1.23591252
55MP0003329_amyloid_beta_deposits1.23343887
56MP0004484_altered_response_of1.23176168
57MP0002127_abnormal_cardiovascular_syste1.22862281
58MP0002882_abnormal_neuron_morphology1.21395622
59MP0001984_abnormal_olfaction1.20154842
60MP0004858_abnormal_nervous_system1.18749128
61MP0000920_abnormal_myelination1.16163362
62MP0003631_nervous_system_phenotype1.14821928
63MP0001529_abnormal_vocalization1.13926181
64MP0008438_abnormal_cutaneous_collagen1.13382379
65MP0003879_abnormal_hair_cell1.13351546
66MP0002837_dystrophic_cardiac_calcinosis1.13180645
67MP0004742_abnormal_vestibular_system1.12919541
68MP0003122_maternal_imprinting1.12802546
69MP0005409_darkened_coat_color1.06025215
70MP0001502_abnormal_circadian_rhythm1.05945505
71MP0002152_abnormal_brain_morphology1.04798689
72MP0002295_abnormal_pulmonary_circulatio1.04227899
73MP0008775_abnormal_heart_ventricle1.04190733
74MP0004142_abnormal_muscle_tone1.03275771
75MP0002168_other_aberrant_phenotype1.03032777
76MP0004133_heterotaxia1.02590247
77MP0001905_abnormal_dopamine_level0.99287309
78MP0006138_congestive_heart_failure0.98411927
79MP0001299_abnormal_eye_distance/0.97466295
80MP0005503_abnormal_tendon_morphology0.96284378
81MP0005187_abnormal_penis_morphology0.96143561
82MP0005248_abnormal_Harderian_gland0.96087534
83MP0000013_abnormal_adipose_tissue0.96080430
84MP0001346_abnormal_lacrimal_gland0.95695673
85MP0010386_abnormal_urinary_bladder0.95656572
86MP0006072_abnormal_retinal_apoptosis0.94922843
87MP0004084_abnormal_cardiac_muscle0.93132613
88MP0003950_abnormal_plasma_membrane0.92709313
89MP0005253_abnormal_eye_physiology0.92343045
90MP0008874_decreased_physiological_sensi0.92330061
91MP0004036_abnormal_muscle_relaxation0.88517246
92MP0002909_abnormal_adrenal_gland0.88099630
93MP0003890_abnormal_embryonic-extraembry0.85845113
94MP0003045_fibrosis0.85517140
95MP0003828_pulmonary_edema0.84648255
96MP0001177_atelectasis0.84147406
97MP0003690_abnormal_glial_cell0.83645983
98MP0001485_abnormal_pinna_reflex0.83619778
99MP0003137_abnormal_impulse_conducting0.82682857
100MP0003935_abnormal_craniofacial_develop0.81434472
101MP0001958_emphysema0.80753932
102MP0000534_abnormal_ureter_morphology0.80133692
103MP0003632_abnormal_nervous_system0.80123230
104MP0002332_abnormal_exercise_endurance0.79046080
105MP0008872_abnormal_physiological_respon0.78944939
106MP0003385_abnormal_body_wall0.78771659
107MP0005620_abnormal_muscle_contractility0.78646632
108MP0003091_abnormal_cell_migration0.76658075
109MP0005379_endocrine/exocrine_gland_phen0.75740533
110MP0003634_abnormal_glial_cell0.75222631
111MP0001963_abnormal_hearing_physiology0.74902646
112MP0002928_abnormal_bile_duct0.74716427
113MP0008877_abnormal_DNA_methylation0.73811162
114MP0003283_abnormal_digestive_organ0.73349395
115MP0005195_abnormal_posterior_eye0.73116338
116MP0004510_myositis0.73011019
117MP0002229_neurodegeneration0.70781389
118MP0005551_abnormal_eye_electrophysiolog0.70186117
119MP0002069_abnormal_eating/drinking_beha0.69946406
120MP0000631_abnormal_neuroendocrine_gland0.69937177
121MP0002752_abnormal_somatic_nervous0.67852442
122MP0005535_abnormal_body_temperature0.66382952
123MP0005595_abnormal_vascular_smooth0.66069365
124MP0004883_abnormal_blood_vessel0.65003736
125MP0005165_increased_susceptibility_to0.63973440
126MP0002972_abnormal_cardiac_muscle0.63744056

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.70425168
2Myokymia (HP:0002411)5.68711468
3Focal seizures (HP:0007359)5.08120971
4Epileptic encephalopathy (HP:0200134)4.35381794
5Atonic seizures (HP:0010819)4.31848254
6Febrile seizures (HP:0002373)4.26660059
7Hyperventilation (HP:0002883)4.07996506
8Broad-based gait (HP:0002136)3.94797660
9Progressive cerebellar ataxia (HP:0002073)3.55390487
10Hematochezia (HP:0002573)3.43913071
11Visual hallucinations (HP:0002367)3.40438414
12Action tremor (HP:0002345)3.37815114
13Absence seizures (HP:0002121)3.33827567
14Gaze-evoked nystagmus (HP:0000640)3.27209920
15Poor eye contact (HP:0000817)3.16686142
16Generalized tonic-clonic seizures (HP:0002069)3.15721981
17Dysmetria (HP:0001310)3.08985324
18Dialeptic seizures (HP:0011146)3.04142059
19Ankle clonus (HP:0011448)2.95368315
20Limb dystonia (HP:0002451)2.94307865
21Dysdiadochokinesis (HP:0002075)2.93761321
22Overgrowth (HP:0001548)2.90063269
23Urinary urgency (HP:0000012)2.88989396
24Impaired vibration sensation in the lower limbs (HP:0002166)2.86195718
25Impaired social interactions (HP:0000735)2.82232013
26Abnormal social behavior (HP:0012433)2.82232013
27Abnormality of the corticospinal tract (HP:0002492)2.81052227
28Wrist flexion contracture (HP:0001239)2.77297208
29Scanning speech (HP:0002168)2.76498852
30Termporal pattern (HP:0011008)2.74213725
31Insidious onset (HP:0003587)2.74213725
32Drooling (HP:0002307)2.73283776
33Excessive salivation (HP:0003781)2.73283776
34Urinary bladder sphincter dysfunction (HP:0002839)2.68639371
35Absent speech (HP:0001344)2.68218596
36Supranuclear gaze palsy (HP:0000605)2.67388445
37Lower limb amyotrophy (HP:0007210)2.64893627
38Abnormality of the ischium (HP:0003174)2.61388049
39Supraventricular arrhythmia (HP:0005115)2.56591359
40Lower limb muscle weakness (HP:0007340)2.55845486
41Spastic gait (HP:0002064)2.55016180
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53175419
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.53175419
44Torticollis (HP:0000473)2.50761004
45Amblyopia (HP:0000646)2.50718103
46Truncal ataxia (HP:0002078)2.50490838
47Limited hip movement (HP:0008800)2.44864074
48Blue irides (HP:0000635)2.43315257
49Neurofibrillary tangles (HP:0002185)2.42250078
50Intention tremor (HP:0002080)2.41636446
51Depression (HP:0000716)2.40049133
52Anxiety (HP:0000739)2.38170911
53Short chin (HP:0000331)2.33830052
54Abnormal eating behavior (HP:0100738)2.32161658
55Hemiplegia (HP:0002301)2.30760560
56Fetal akinesia sequence (HP:0001989)2.30263183
57Supraventricular tachycardia (HP:0004755)2.28236467
58Hemiparesis (HP:0001269)2.28145593
59Broad metatarsal (HP:0001783)2.27926116
60Genetic anticipation (HP:0003743)2.27862546
61Progressive inability to walk (HP:0002505)2.26909954
62Portal hypertension (HP:0001409)2.26030128
63Spontaneous hematomas (HP:0007420)2.25356104
64Hypoplastic ischia (HP:0003175)2.25167362
65Prolonged QT interval (HP:0001657)2.21067688
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20748548
67Short 4th metacarpal (HP:0010044)2.20748548
68Bundle branch block (HP:0011710)2.20132952
69Incomplete penetrance (HP:0003829)2.19349082
70Lymphangioma (HP:0100764)2.18999077
71Cerebral inclusion bodies (HP:0100314)2.17434655
72Focal dystonia (HP:0004373)2.16427258
73Mutism (HP:0002300)2.16408438
74Epileptiform EEG discharges (HP:0011182)2.13094657
75Bulbous nose (HP:0000414)2.12895548
76Postural instability (HP:0002172)2.12484577
77Stereotypic behavior (HP:0000733)2.11182442
78Adactyly (HP:0009776)2.09724072
79Impaired smooth pursuit (HP:0007772)2.09423515
80Papilledema (HP:0001085)2.09150634
81Prominent supraorbital ridges (HP:0000336)2.06778700
82Cutaneous finger syndactyly (HP:0010554)2.05963271
83Inability to walk (HP:0002540)2.04007917
84Abnormality of salivation (HP:0100755)2.02874303
85Hypoplasia of the iris (HP:0007676)2.00938200
86Sudden death (HP:0001699)2.00302621
87Keratoconus (HP:0000563)2.00093223
88Increased corneal curvature (HP:0100692)2.00093223
89Oligomenorrhea (HP:0000876)1.99433688
90EEG with generalized epileptiform discharges (HP:0011198)1.98751531
91Fair hair (HP:0002286)1.98295118
92Craniofacial dystonia (HP:0012179)1.96498244
93Pheochromocytoma (HP:0002666)1.96312412
94Dysmetric saccades (HP:0000641)1.96116464
95Syncope (HP:0001279)1.96080869
96Abnormality of the hepatic vasculature (HP:0006707)1.95716388
97Protruding tongue (HP:0010808)1.91458622
98Abnormality of binocular vision (HP:0011514)1.90633711
99Diplopia (HP:0000651)1.90633711
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.88557359
101Absent/shortened dynein arms (HP:0200106)1.88557359
102Intestinal atresia (HP:0011100)1.88088520
103Difficulty running (HP:0009046)1.87456462
104Hip contracture (HP:0003273)1.87311052
105Abnormal EKG (HP:0003115)1.86959621
106Onion bulb formation (HP:0003383)1.86903412
107Gait ataxia (HP:0002066)1.86596792
108Pancreatic cysts (HP:0001737)1.86542965
109Hypsarrhythmia (HP:0002521)1.85583356
110Thickened helices (HP:0000391)1.85112987
111Annular pancreas (HP:0001734)1.84036959
112Impaired vibratory sensation (HP:0002495)1.82477127
113Increased circulating renin level (HP:0000848)1.82255332
114Palpebral edema (HP:0100540)1.81119918
115Wide anterior fontanel (HP:0000260)1.81103471
116Visceral angiomatosis (HP:0100761)1.79875555
117Chronic hepatic failure (HP:0100626)1.79620236
118Pancreatic fibrosis (HP:0100732)1.79276150
119Widely spaced teeth (HP:0000687)1.79255817
120Scotoma (HP:0000575)1.78970742
121True hermaphroditism (HP:0010459)1.78871167
122Conjunctival telangiectasia (HP:0000524)1.78632057
123Atrial fibrillation (HP:0005110)1.78447635
124Exotropia (HP:0000577)1.78309945
125Cerebral aneurysm (HP:0004944)1.77696738
126Bradykinesia (HP:0002067)1.77465534
127Molar tooth sign on MRI (HP:0002419)1.76981585
128Abnormality of midbrain morphology (HP:0002418)1.76981585
129Generalized hypopigmentation of hair (HP:0011358)1.76334218
130Abnormality of the renal medulla (HP:0100957)1.76255427
131Primary atrial arrhythmia (HP:0001692)1.76128505
132Cerebral hemorrhage (HP:0001342)1.75383377
133Nephronophthisis (HP:0000090)1.75249445
134Horizontal nystagmus (HP:0000666)1.74524246
135Neuroendocrine neoplasm (HP:0100634)1.72915279
136Pachygyria (HP:0001302)1.72886643
137Esophageal varix (HP:0002040)1.72694394
138Striae distensae (HP:0001065)1.72652945
139Gait imbalance (HP:0002141)1.72359625
140Abnormality of the renal cortex (HP:0011035)1.71764286
141Abnormality of ocular smooth pursuit (HP:0000617)1.71618621
142Ventricular fibrillation (HP:0001663)1.70535961
143Status epilepticus (HP:0002133)1.70174516
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69703203
145Arterial tortuosity (HP:0005116)1.69685680
146Myotonia (HP:0002486)1.69577977
147Akinesia (HP:0002304)1.68010222
148Clonus (HP:0002169)1.67483182
149Abnormality of the right ventricle (HP:0001707)1.66953518
150Left ventricular hypertrophy (HP:0001712)1.66931948
151Abnormality of the labia minora (HP:0012880)1.66831125
152Medial flaring of the eyebrow (HP:0010747)1.66608357
153Polyphagia (HP:0002591)1.66218519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.82776708
2EPHA43.79349934
3FRK3.77391115
4MARK13.04691283
5MAP3K42.86894387
6MAP3K92.85113150
7CASK2.71013972
8MAP2K72.44180251
9TIE12.25438871
10DAPK22.22651902
11OXSR12.06938742
12MINK12.05616874
13MAP2K41.87424222
14NTRK21.83476099
15STK391.78872472
16PAK61.64465555
17NTRK11.51079260
18PNCK1.49839643
19PRPF4B1.49430063
20KSR21.40889039
21CDK51.38745444
22TNIK1.37503473
23WNK41.34080459
24SGK2231.33754994
25SGK4941.33754994
26PINK11.30214884
27PLK21.30146307
28RIPK41.26816597
29MAPK131.26373101
30MAP4K21.26370804
31BMPR1B1.24136109
32PRKD31.22646869
33CDK191.22137615
34CAMKK11.19547257
35PHKG11.18615866
36PHKG21.18615866
37KSR11.15687340
38AKT31.13835568
39MAP3K121.13307016
40SGK21.13272189
41GRK51.12502502
42TGFBR21.12477110
43KDR1.11503235
44CAMKK21.10659449
45PTK2B1.10482208
46TRPM71.10014586
47RIPK11.08521397
48LATS21.04643809
49TYRO31.03294835
50MYLK1.02192059
51UHMK11.00629085
52ADRBK20.99714227
53CAMK2A0.99143501
54OBSCN0.98316167
55WNK10.95087718
56SIK20.94537242
57DAPK10.92864083
58PRKCG0.90671181
59STK380.90439234
60PAK30.88430160
61CAMK2B0.88327721
62BCR0.86962990
63EPHA30.86881636
64TGFBR10.85276287
65NEK90.83624384
66SGK30.83235225
67ROCK10.82582718
68NEK60.82570131
69CSNK1G20.82034070
70BMPR20.81628568
71INSRR0.81465135
72PRKCH0.80725084
73STK38L0.80667803
74MARK20.80429703
75FGFR20.79995249
76PDPK10.79965773
77STK110.77151896
78CAMK10.75848589
79FES0.75307337
80DMPK0.75168652
81MAP3K130.72406683
82PKN10.71886400
83EPHA20.70781703
84FER0.70662836
85SGK10.70511363
86PRKCE0.69792435
87ARAF0.67509899
88MAP3K20.67160756
89RET0.67140049
90CDK180.65299350
91PRKCZ0.65034649
92CDK140.64629905
93GRK10.64596944
94CDK150.63587057
95CCNB10.63430032
96PDK10.63310234
97MAPK120.63147126
98CAMK1G0.61641375
99CAMK2D0.61561831
100TEC0.61474656
101EPHB20.61177176
102CSNK1G10.61018739
103ADRBK10.60948403
104PIK3CA0.60040607
105WNK30.59761887
106MAP3K60.56622469
107PRKG10.56584185
108CSNK1A1L0.52701015
109MAP2K60.51368055
110CDK11A0.49224145
111DYRK1A0.48821664
112MAPK70.47312827
113DDR20.46337107
114CAMK2G0.46196037
115PDGFRB0.45590303
116CAMK40.44556962
117PRKD10.44519621
118PTK20.44289130
119ROCK20.43394001
120LATS10.42301152
121MAP2K10.41500095
122RPS6KA30.40877623
123FGR0.40709648
124NLK0.39383430
125PRKAA10.38511727
126CSNK1G30.38425730
127FYN0.38420389
128PDGFRA0.38386169
129PRKAA20.36547719

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39441213
2Synaptic vesicle cycle_Homo sapiens_hsa047212.57283419
3Circadian entrainment_Homo sapiens_hsa047132.54291253
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52259160
5Morphine addiction_Homo sapiens_hsa050322.50091812
6GABAergic synapse_Homo sapiens_hsa047272.48044863
7Olfactory transduction_Homo sapiens_hsa047402.45827812
8Glutamatergic synapse_Homo sapiens_hsa047242.41974009
9Long-term potentiation_Homo sapiens_hsa047202.33767764
10Salivary secretion_Homo sapiens_hsa049702.12979337
11Amphetamine addiction_Homo sapiens_hsa050312.12324753
12Dopaminergic synapse_Homo sapiens_hsa047281.92638939
13Taste transduction_Homo sapiens_hsa047421.86528457
14Renin secretion_Homo sapiens_hsa049241.86403053
15Gastric acid secretion_Homo sapiens_hsa049711.81846349
16Cholinergic synapse_Homo sapiens_hsa047251.78532358
17Insulin secretion_Homo sapiens_hsa049111.77353934
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75895787
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71056243
20Long-term depression_Homo sapiens_hsa047301.70351007
21Serotonergic synapse_Homo sapiens_hsa047261.63054644
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62280944
23Axon guidance_Homo sapiens_hsa043601.61911584
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58628855
25Calcium signaling pathway_Homo sapiens_hsa040201.54575679
26Cocaine addiction_Homo sapiens_hsa050301.53852452
27Gap junction_Homo sapiens_hsa045401.41066868
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34967194
29cAMP signaling pathway_Homo sapiens_hsa040241.34692080
30Dorso-ventral axis formation_Homo sapiens_hsa043201.33144658
31GnRH signaling pathway_Homo sapiens_hsa049121.28521621
32Dilated cardiomyopathy_Homo sapiens_hsa054141.21789071
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16675965
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16335797
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.15689542
36Collecting duct acid secretion_Homo sapiens_hsa049661.15560836
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14371183
38Estrogen signaling pathway_Homo sapiens_hsa049151.14206643
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13661937
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12736253
41Melanogenesis_Homo sapiens_hsa049161.09068479
42Type II diabetes mellitus_Homo sapiens_hsa049301.04407266
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03648748
44Nitrogen metabolism_Homo sapiens_hsa009101.02858389
45ErbB signaling pathway_Homo sapiens_hsa040121.02615606
46TGF-beta signaling pathway_Homo sapiens_hsa043500.99986780
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99935406
48Glioma_Homo sapiens_hsa052140.96542382
49ABC transporters_Homo sapiens_hsa020100.95454512
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94896659
51Cardiac muscle contraction_Homo sapiens_hsa042600.94252996
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92792473
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.89082829
54Rap1 signaling pathway_Homo sapiens_hsa040150.86536067
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86325814
56Pancreatic secretion_Homo sapiens_hsa049720.85222899
57Ras signaling pathway_Homo sapiens_hsa040140.84658882
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79884591
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79017538
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.76933563
61MAPK signaling pathway_Homo sapiens_hsa040100.76544086
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76182440
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76128386
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74732460
65Choline metabolism in cancer_Homo sapiens_hsa052310.74570695
66Ovarian steroidogenesis_Homo sapiens_hsa049130.74305574
67Thyroid hormone synthesis_Homo sapiens_hsa049180.74095337
68Butanoate metabolism_Homo sapiens_hsa006500.72361979
69Protein digestion and absorption_Homo sapiens_hsa049740.71232716
70Selenocompound metabolism_Homo sapiens_hsa004500.69893255
71Basal cell carcinoma_Homo sapiens_hsa052170.69077221
72Phototransduction_Homo sapiens_hsa047440.66823790
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66368301
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64729905
75Vibrio cholerae infection_Homo sapiens_hsa051100.62179058
76Wnt signaling pathway_Homo sapiens_hsa043100.61940857
77Oocyte meiosis_Homo sapiens_hsa041140.61147914
78Adherens junction_Homo sapiens_hsa045200.61002167
79VEGF signaling pathway_Homo sapiens_hsa043700.60181469
80Renal cell carcinoma_Homo sapiens_hsa052110.60138529
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.59971951
82Bile secretion_Homo sapiens_hsa049760.59350147
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57568956
84Tight junction_Homo sapiens_hsa045300.56609601
85African trypanosomiasis_Homo sapiens_hsa051430.55576964
86Inositol phosphate metabolism_Homo sapiens_hsa005620.52117847
87Ether lipid metabolism_Homo sapiens_hsa005650.50199910
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48994937
89Proteoglycans in cancer_Homo sapiens_hsa052050.48975233
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48000741
91Endocytosis_Homo sapiens_hsa041440.47544241
92Focal adhesion_Homo sapiens_hsa045100.46593001
93Circadian rhythm_Homo sapiens_hsa047100.45077345
94Prion diseases_Homo sapiens_hsa050200.44438594
95Glucagon signaling pathway_Homo sapiens_hsa049220.42449058
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42166518
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39773936
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39704277
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39394063
100Amoebiasis_Homo sapiens_hsa051460.39233066
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38963121
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38821383
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38464743
104Pathways in cancer_Homo sapiens_hsa052000.36969521
105Mineral absorption_Homo sapiens_hsa049780.36858140
106Endometrial cancer_Homo sapiens_hsa052130.36850162
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.36052973
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.36017986
109mTOR signaling pathway_Homo sapiens_hsa041500.34135158
110Alcoholism_Homo sapiens_hsa050340.34079417
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33102133
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31812278
113Platelet activation_Homo sapiens_hsa046110.31416325
114Tryptophan metabolism_Homo sapiens_hsa003800.31043154
115Hedgehog signaling pathway_Homo sapiens_hsa043400.30025412
116Hippo signaling pathway_Homo sapiens_hsa043900.29133263
117ECM-receptor interaction_Homo sapiens_hsa045120.28600602
118Chemokine signaling pathway_Homo sapiens_hsa040620.28272092
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27892161

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