HEG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)5.21199304
2blood vessel maturation (GO:0001955)5.00085413
3retina vasculature morphogenesis in camera-type eye (GO:0061299)4.86815337
4cell adhesion mediated by integrin (GO:0033627)4.83413703
5skin morphogenesis (GO:0043589)4.76871832
6endodermal cell differentiation (GO:0035987)4.55630764
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.26165024
8protein heterotrimerization (GO:0070208)4.26052181
9glomerular filtration (GO:0003094)4.09749730
10* lymph vessel development (GO:0001945)4.06760026
11cardiac myofibril assembly (GO:0055003)4.03996380
12lymphangiogenesis (GO:0001946)4.00015134
13renal filtration (GO:0097205)3.97615240
14heart trabecula formation (GO:0060347)3.89761095
15type B pancreatic cell proliferation (GO:0044342)3.83145675
16chondrocyte proliferation (GO:0035988)3.78489436
17positive regulation of vasculogenesis (GO:2001214)3.74743848
18surfactant homeostasis (GO:0043129)3.72633444
19bone trabecula formation (GO:0060346)3.71541275
20kidney mesenchyme development (GO:0072074)3.69659314
21endothelium development (GO:0003158)3.62061312
22glomerular basement membrane development (GO:0032836)3.57422315
23metanephric mesenchyme development (GO:0072075)3.57289765
24sarcomere organization (GO:0045214)3.52855713
25cell-substrate junction assembly (GO:0007044)3.49805760
26wound healing, spreading of epidermal cells (GO:0035313)3.46790059
27basement membrane organization (GO:0071711)3.46551864
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.44175756
29mesenchymal-epithelial cell signaling (GO:0060638)3.40631232
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.39793474
31negative regulation of chondrocyte differentiation (GO:0032331)3.39123847
32collagen fibril organization (GO:0030199)3.37387794
33* venous blood vessel morphogenesis (GO:0048845)3.36131237
34collagen catabolic process (GO:0030574)3.35798641
35negative regulation of smooth muscle cell migration (GO:0014912)3.35185507
36extracellular fibril organization (GO:0043206)3.34437818
37myofibril assembly (GO:0030239)3.34246352
38plasma membrane repair (GO:0001778)3.33285026
39regulation of vasculogenesis (GO:2001212)3.32936497
40regulation of endothelial cell differentiation (GO:0045601)3.32810789
41multicellular organismal macromolecule metabolic process (GO:0044259)3.29825898
42patterning of blood vessels (GO:0001569)3.27697515
43trabecula formation (GO:0060343)3.24544126
44virion attachment to host cell (GO:0019062)3.23821881
45adhesion of symbiont to host cell (GO:0044650)3.23821881
46morphogenesis of an endothelium (GO:0003159)3.16598685
47endothelial tube morphogenesis (GO:0061154)3.16598685
48endocardial cushion development (GO:0003197)3.15537332
49peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15411777
50stress fiber assembly (GO:0043149)3.14151128
51multicellular organismal metabolic process (GO:0044236)3.11551967
52hemidesmosome assembly (GO:0031581)3.11529705
53coronary vasculature morphogenesis (GO:0060977)3.11284038
54extracellular matrix disassembly (GO:0022617)3.10038362
55fibril organization (GO:0097435)3.09972327
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.09584385
57cell migration involved in sprouting angiogenesis (GO:0002042)3.08767639
58ovulation from ovarian follicle (GO:0001542)3.07063830
59multicellular organismal catabolic process (GO:0044243)3.04418657
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02830484
61glomerulus development (GO:0032835)3.02779227
62substrate-dependent cell migration (GO:0006929)3.02462259
63barbed-end actin filament capping (GO:0051016)3.01883005
64apoptotic cell clearance (GO:0043277)3.01736750
65cellular response to vitamin (GO:0071295)3.00686789
66neuron projection extension involved in neuron projection guidance (GO:1902284)2.99483435
67axon extension involved in axon guidance (GO:0048846)2.99483435
68definitive hemopoiesis (GO:0060216)2.99243163
69Golgi transport vesicle coating (GO:0048200)2.98426071
70COPI coating of Golgi vesicle (GO:0048205)2.98426071
71wound healing, spreading of cells (GO:0044319)2.98342855
72atrioventricular valve morphogenesis (GO:0003181)2.96806753
73positive regulation of receptor recycling (GO:0001921)2.95776160
74chondrocyte development (GO:0002063)2.94560890
75fibroblast migration (GO:0010761)2.93945011
76adherens junction assembly (GO:0034333)2.93641987
77negative regulation of heart growth (GO:0061117)2.92997212
78negative regulation of cardiac muscle tissue growth (GO:0055022)2.92997212
79positive regulation of extracellular matrix organization (GO:1903055)2.91130533
80sprouting angiogenesis (GO:0002040)2.90619801
81regulation of relaxation of muscle (GO:1901077)2.90036609
82substrate adhesion-dependent cell spreading (GO:0034446)2.89835474
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.89100929
84protein localization to endosome (GO:0036010)2.88714755
85extracellular matrix organization (GO:0030198)2.88294064
86positive regulation of osteoblast proliferation (GO:0033690)2.87757807
87focal adhesion assembly (GO:0048041)2.87431198
88cell-substrate adherens junction assembly (GO:0007045)2.87431198
89extracellular structure organization (GO:0043062)2.87108956
90adhesion of symbiont to host (GO:0044406)2.86627642
91regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.86430982
92cell migration involved in heart development (GO:0060973)2.85700581
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85560045
94regulation of integrin-mediated signaling pathway (GO:2001044)2.83527750
95regulation of transforming growth factor beta2 production (GO:0032909)2.83344572
96regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.82664816
97hyaluronan catabolic process (GO:0030214)2.81471787
98peptidyl-tyrosine autophosphorylation (GO:0038083)2.81117016
99hypotonic response (GO:0006971)2.80467453
100ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.80175644
101heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78435352
102regulation of extracellular matrix disassembly (GO:0010715)2.76950380
103chemical homeostasis within a tissue (GO:0048875)2.75169490
104cardiac muscle tissue morphogenesis (GO:0055008)2.73256126
105regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.72971904
106maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72905670
107positive regulation of glycogen biosynthetic process (GO:0045725)2.72614984
108regulation of actin filament-based movement (GO:1903115)2.71175957
109smooth muscle tissue development (GO:0048745)2.70930540
110blood vessel endothelial cell migration (GO:0043534)2.70085114
111positive regulation of fatty acid oxidation (GO:0046321)2.69723316
112actomyosin structure organization (GO:0031032)2.69395275
113mesodermal cell differentiation (GO:0048333)2.69237439
114protein retention in ER lumen (GO:0006621)2.68871164
115regulation of skeletal muscle contraction (GO:0014819)2.68738184
116angiogenesis involved in wound healing (GO:0060055)2.68653785
117extracellular matrix assembly (GO:0085029)2.68010335
118negative regulation of nitric-oxide synthase activity (GO:0051001)2.67791250
119establishment of endothelial barrier (GO:0061028)2.67635847
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67159412
121positive regulation of fibroblast migration (GO:0010763)2.67133989
122endothelial cell differentiation (GO:0045446)2.65852677
123atrial septum morphogenesis (GO:0060413)2.64229127
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63822990
125cell proliferation involved in metanephros development (GO:0072203)2.63467808
126sequestering of extracellular ligand from receptor (GO:0035581)2.63230740
127cardiac muscle cell proliferation (GO:0060038)2.62548765
128cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62078541
129heart morphogenesis (GO:0003007)2.62042092
130negative regulation of osteoblast proliferation (GO:0033689)2.60767232
131regulation of plasminogen activation (GO:0010755)2.59982004
132muscle filament sliding (GO:0030049)2.59633327
133actin-myosin filament sliding (GO:0033275)2.59633327
134keratan sulfate catabolic process (GO:0042340)2.59557070
135negative regulation of Rho protein signal transduction (GO:0035024)2.59339664
136* vasculogenesis (GO:0001570)2.59109918
137regulation of osteoblast proliferation (GO:0033688)2.58102203
138positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57613632
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57204128
140response to fluid shear stress (GO:0034405)2.56955781
141paraxial mesoderm development (GO:0048339)2.56780827
142dermatan sulfate biosynthetic process (GO:0030208)2.56471971
143regulation of sarcomere organization (GO:0060297)2.56289702
144regulation of cardioblast differentiation (GO:0051890)2.56214408
145blood vessel remodeling (GO:0001974)2.55832159
146peptidyl-proline hydroxylation (GO:0019511)2.55651261
147cellular response to vitamin D (GO:0071305)2.54127984
148negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.54079228
149membrane raft organization (GO:0031579)2.53711532
150regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.53202055
151epithelial cell-cell adhesion (GO:0090136)2.52915392
152endocardial cushion morphogenesis (GO:0003203)2.52685572
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52584407
154negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.52029056
155cortical actin cytoskeleton organization (GO:0030866)2.51221754
156negative regulation of cartilage development (GO:0061037)2.51074515
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50859003
158regulation of p38MAPK cascade (GO:1900744)2.50007376
159muscle tissue morphogenesis (GO:0060415)2.48477104
160glomerular visceral epithelial cell development (GO:0072015)2.47763043
161actin-mediated cell contraction (GO:0070252)2.45009929
162positive regulation of endothelial cell differentiation (GO:0045603)2.43812574
163carnitine shuttle (GO:0006853)2.43133900
164fatty acid transmembrane transport (GO:1902001)2.42381753
165response to follicle-stimulating hormone (GO:0032354)2.41633700
166lung vasculature development (GO:0060426)2.40493361
167mRNA transcription (GO:0009299)2.37585567
168negative regulation of fatty acid transport (GO:2000192)2.36939377
169collagen metabolic process (GO:0032963)2.36434503
170* endothelial cell morphogenesis (GO:0001886)2.35923797
171negative regulation of potassium ion transmembrane transport (GO:1901380)2.35918170
172artery development (GO:0060840)2.35879218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.72032640
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40116185
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.14116162
4* EP300_21415370_ChIP-Seq_HL-1_Mouse3.11580129
5CLOCK_20551151_ChIP-Seq_293T_Human3.00546500
6GATA2_21666600_ChIP-Seq_HMVEC_Human2.98838015
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89873171
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.80331194
9* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61245403
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41807149
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.41675520
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21310370
13CJUN_26792858_Chip-Seq_BT549_Human2.20181285
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.16266841
15GATA1_22025678_ChIP-Seq_K562_Human2.15092263
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.13655735
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.13655735
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12581513
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08685212
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07277020
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03905113
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.00911694
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.99494161
24* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84126625
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76091290
26* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75795312
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75748669
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74038756
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.71366498
30RUNX_20019798_ChIP-Seq_JUKART_Human1.69895035
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68888108
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67896938
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66979851
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.65246036
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62802286
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61752321
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61436814
38* BRD4_25478319_ChIP-Seq_HGPS_Human1.58984710
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57040528
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.51186927
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49895461
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47556516
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45177351
44SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43609789
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42695286
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42193929
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41347506
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.39832034
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38218007
50AHR_22903824_ChIP-Seq_MCF-7_Human1.38040200
51TP53_16413492_ChIP-PET_HCT116_Human1.37840148
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37306154
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35389250
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35389250
55* ESR2_21235772_ChIP-Seq_MCF-7_Human1.35336384
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.33057494
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.32460802
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.31163973
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.30749637
60TP53_22127205_ChIP-Seq_IMR90_Human1.27023443
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25443035
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25327515
63SCL_19346495_ChIP-Seq_HPC-7_Human1.23487450
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22420758
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21713754
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.21614272
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21000415
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20728335
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19447945
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19447945
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17339050
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16081170
73SA1_22415368_ChIP-Seq_MEFs_Mouse1.15644374
74* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15544626
75GATA1_19941826_ChIP-Seq_K562_Human1.14094193
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13840262
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13666611
78AR_21572438_ChIP-Seq_LNCaP_Human1.11735866
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11056525
80SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10064465
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10001427
82VDR_24787735_ChIP-Seq_THP-1_Human1.09954268
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08713100
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08699539
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08041001
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07611982
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07384900
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07291624
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07064781
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.07025196
91* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05583798
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05439622
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05070438
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.04986609
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04330829
96* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03853330
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02876421
98TP53_18474530_ChIP-ChIP_U2OS_Human1.02814617
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01288362
100* SOX2_20726797_ChIP-Seq_SW620_Human1.00776771
101* KDM2B_26808549_Chip-Seq_K562_Human0.98646855
102* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96692458
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96243066
104* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96135958
105* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95430127
106* KDM2B_26808549_Chip-Seq_DND41_Human0.95029755
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94890454
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.94880228
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.94694687
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92296940
111SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91065250
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90959197
113* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90763002
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90587630
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89900764
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89707447
117RACK7_27058665_Chip-Seq_MCF-7_Human0.89602761
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89264073
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89201034
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88530787
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88311275
122* BCAT_22108803_ChIP-Seq_LS180_Human0.88235841
123TP63_23658742_ChIP-Seq_EP156T_Human0.88167208
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88137729
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87357532
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87357532
127DROSHA_22980978_ChIP-Seq_HELA_Human0.87229920
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87201603
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87195702
130GATA2_19941826_ChIP-Seq_K562_Human0.87026682
131MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85150700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.47382191
2MP0005503_abnormal_tendon_morphology3.74771769
3MP0005275_abnormal_skin_tensile3.58517397
4* MP0010368_abnormal_lymphatic_system3.47197177
5MP0004272_abnormal_basement_membrane3.46614886
6MP0005257_abnormal_intraocular_pressure3.33844419
7* MP0001879_abnormal_lymphatic_vessel3.28873054
8MP0004084_abnormal_cardiac_muscle3.18611122
9MP0003279_aneurysm3.03396525
10MP0001958_emphysema2.99847474
11MP0000751_myopathy2.51677239
12MP0002837_dystrophic_cardiac_calcinosis2.47503783
13MP0003828_pulmonary_edema2.47071632
14MP0003705_abnormal_hypodermis_morpholog2.31922648
15MP0004215_abnormal_myocardial_fiber2.29253117
16MP0005330_cardiomyopathy2.15791214
17MP0006054_spinal_hemorrhage2.05223496
18MP0004036_abnormal_muscle_relaxation2.01806345
19MP0006138_congestive_heart_failure2.01707388
20MP0001542_abnormal_bone_strength1.91483794
21MP0003950_abnormal_plasma_membrane1.88060408
22MP0003566_abnormal_cell_adhesion1.86295609
23MP0003724_increased_susceptibility_to1.80807584
24MP0001544_abnormal_cardiovascular_syste1.80433816
25MP0005385_cardiovascular_system_phenoty1.80433816
26MP0008775_abnormal_heart_ventricle1.80259008
27MP0005670_abnormal_white_adipose1.78811832
28MP0010630_abnormal_cardiac_muscle1.78450214
29MP0002108_abnormal_muscle_morphology1.76723326
30MP0000767_abnormal_smooth_muscle1.76705668
31MP0002972_abnormal_cardiac_muscle1.72223625
32MP0004484_altered_response_of1.70711180
33MP0005167_abnormal_blood-brain_barrier1.67414914
34MP0002877_abnormal_melanocyte_morpholog1.65423983
35MP0010352_gastrointestinal_tract_polyps1.60756408
36MP0010030_abnormal_orbit_morphology1.60407124
37MP0003941_abnormal_skin_development1.58086808
38MP0003300_gastrointestinal_ulcer1.57296532
39MP0005623_abnormal_meninges_morphology1.56540226
40MP0000749_muscle_degeneration1.55973168
41MP0009384_cardiac_valve_regurgitation1.55633233
42MP0000013_abnormal_adipose_tissue1.54632881
43MP0004087_abnormal_muscle_fiber1.54197139
44MP0005620_abnormal_muscle_contractility1.47770949
45MP0002166_altered_tumor_susceptibility1.47432649
46MP0004130_abnormal_muscle_cell1.44493094
47MP0001299_abnormal_eye_distance/1.38753176
48MP0000750_abnormal_muscle_regeneration1.38399274
49MP0003045_fibrosis1.37111571
50MP0000003_abnormal_adipose_tissue1.36017631
51* MP0002128_abnormal_blood_circulation1.32712060
52MP0001348_abnormal_lacrimal_gland1.32474700
53MP0005508_abnormal_skeleton_morphology1.32253826
54MP0000733_abnormal_muscle_development1.31244658
55MP0000534_abnormal_ureter_morphology1.30485985
56MP0000343_altered_response_to1.27292384
57MP0002127_abnormal_cardiovascular_syste1.25835551
58MP0001243_abnormal_dermal_layer1.23862200
59MP0003567_abnormal_fetal_cardiomyocyte1.22879203
60MP0005165_increased_susceptibility_to1.22310834
61MP0004858_abnormal_nervous_system1.20297964
62* MP0002925_abnormal_cardiovascular_devel1.19609888
63MP0009780_abnormal_chondrocyte_physiolo1.19041435
64MP0002060_abnormal_skin_morphology1.18715163
65MP0005375_adipose_tissue_phenotype1.18111403
66MP0005369_muscle_phenotype1.16991060
67MP0003091_abnormal_cell_migration1.14587287
68MP0005666_abnormal_adipose_tissue1.12191355
69* MP0000266_abnormal_heart_morphology1.12091384
70MP0005595_abnormal_vascular_smooth1.11904427
71MP0000428_abnormal_craniofacial_morphol1.11656002
72MP0009053_abnormal_anal_canal1.11321992
73MP0004085_abnormal_heartbeat1.10691474
74MP0002106_abnormal_muscle_physiology1.10062882
75MP0001614_abnormal_blood_vessel1.09730385
76MP0005023_abnormal_wound_healing1.06911073
77MP0004808_abnormal_hematopoietic_stem1.05235314
78MP0003942_abnormal_urinary_system1.04864241
79* MP0002295_abnormal_pulmonary_circulatio1.04109347
80MP0002133_abnormal_respiratory_system1.04078806
81MP0005388_respiratory_system_phenotype1.04078806
82MP0002009_preneoplasia1.02505046
83MP0005409_darkened_coat_color1.00740246
84MP0001849_ear_inflammation0.99992897
85MP0005197_abnormal_uvea_morphology0.98209469
86MP0000249_abnormal_blood_vessel0.97792178
87MP0000759_abnormal_skeletal_muscle0.95350196
88MP0003646_muscle_fatigue0.94798477
89MP0000762_abnormal_tongue_morphology0.94763740
90MP0009278_abnormal_bone_marrow0.92989853
91MP0002006_tumorigenesis0.92139813
92MP0002933_joint_inflammation0.91724021
93MP0003448_altered_tumor_morphology0.89297546
94MP0004147_increased_porphyrin_level0.86927053
95MP0003115_abnormal_respiratory_system0.86533314
96MP0002168_other_aberrant_phenotype0.86312827
97MP0000163_abnormal_cartilage_morphology0.86170871
98MP0002396_abnormal_hematopoietic_system0.83872928
99MP0004233_abnormal_muscle_weight0.82943958
100MP0002138_abnormal_hepatobiliary_system0.82299049
101MP0004883_abnormal_blood_vessel0.81118481
102MP0002896_abnormal_bone_mineralization0.79553827
103MP0005171_absent_coat_pigmentation0.78643578
104MP0005076_abnormal_cell_differentiation0.78185639
105MP0001175_abnormal_lung_morphology0.76720490
106MP0003137_abnormal_impulse_conducting0.76416060
107MP0003943_abnormal_hepatobiliary_system0.75566787
108MP0004134_abnormal_chest_morphology0.75031728
109MP0005164_abnormal_response_to0.74717283
110* MP0001784_abnormal_fluid_regulation0.74669128
111MP0002115_abnormal_skeleton_extremities0.74297101
112MP0000230_abnormal_systemic_arterial0.74261768
113MP0002113_abnormal_skeleton_development0.73599387
114MP0003935_abnormal_craniofacial_develop0.73233640
115MP0000432_abnormal_head_morphology0.72527203
116MP0009250_abnormal_appendicular_skeleto0.71805222
117MP0008004_abnormal_stomach_pH0.71357210
118MP0002998_abnormal_bone_remodeling0.71285994
119MP0005390_skeleton_phenotype0.70285056
120MP0003385_abnormal_body_wall0.69445424
121MP0004510_myositis0.68561013
122MP0005193_abnormal_anterior_eye0.68392701
123MP0001915_intracranial_hemorrhage0.68284267
124MP0010386_abnormal_urinary_bladder0.67361690
125MP0002932_abnormal_joint_morphology0.66613471
126MP0001661_extended_life_span0.63983556
127MP0003755_abnormal_palate_morphology0.63092684
128MP0000462_abnormal_digestive_system0.63045276
129MP0003191_abnormal_cellular_cholesterol0.62218096
130MP0002269_muscular_atrophy0.61824546
131MP0003795_abnormal_bone_structure0.61418626
132MP0009840_abnormal_foam_cell0.61084585
133MP0001533_abnormal_skeleton_physiology0.60723024
134MP0003283_abnormal_digestive_organ0.60443023
135MP0000049_abnormal_middle_ear0.59196908

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.29678055
2Broad metatarsal (HP:0001783)5.29674673
3Aortic aneurysm (HP:0004942)4.43194789
4Cerebral aneurysm (HP:0004944)4.25169164
5Premature rupture of membranes (HP:0001788)4.11148509
6Increased connective tissue (HP:0009025)4.00239249
7Aortic dissection (HP:0002647)3.93152791
8Sudden death (HP:0001699)3.81921405
9Muscle fiber splitting (HP:0003555)3.80994349
10Ventricular tachycardia (HP:0004756)3.59596400
11Lipoatrophy (HP:0100578)3.59083591
12Ankle contracture (HP:0006466)3.54699398
13Hematochezia (HP:0002573)3.47285613
14Atrial fibrillation (HP:0005110)3.45165786
15Pulmonary artery stenosis (HP:0004415)3.41816365
16Abnormality of dentin (HP:0010299)3.37239719
17Right ventricular cardiomyopathy (HP:0011663)3.33864026
18Shallow orbits (HP:0000586)3.33575012
19Neonatal short-limb short stature (HP:0008921)3.33203175
20Polycythemia (HP:0001901)3.22589637
21Aneurysm (HP:0002617)3.15036603
22Primary atrial arrhythmia (HP:0001692)3.11946232
23Vertebral compression fractures (HP:0002953)3.11490789
24Hyporeflexia of lower limbs (HP:0002600)3.10200105
25Spontaneous hematomas (HP:0007420)3.08890031
26Supraventricular arrhythmia (HP:0005115)3.08531069
27Peritonitis (HP:0002586)3.08470245
28Genu recurvatum (HP:0002816)3.03903929
29Supraventricular tachycardia (HP:0004755)2.96021727
30Spinal rigidity (HP:0003306)2.95589356
31Bladder diverticulum (HP:0000015)2.92859565
32Dilatation of the ascending aorta (HP:0005111)2.73505195
33Mitral valve prolapse (HP:0001634)2.71668838
34Abnormality of the left ventricular outflow tract (HP:0011103)2.68761382
35Subaortic stenosis (HP:0001682)2.68761382
36Soft skin (HP:0000977)2.67141718
37Increased variability in muscle fiber diameter (HP:0003557)2.66641675
38Overgrowth (HP:0001548)2.66559353
39Vascular tortuosity (HP:0004948)2.65078000
40Calf muscle hypertrophy (HP:0008981)2.60476804
41Type 1 muscle fiber predominance (HP:0003803)2.60074219
42Lymphangioma (HP:0100764)2.59855304
43Wrist flexion contracture (HP:0001239)2.54880989
44Bowel diverticulosis (HP:0005222)2.52935652
45Wide anterior fontanel (HP:0000260)2.52412874
46Abnormality of the calf musculature (HP:0001430)2.49886604
47Fragile skin (HP:0001030)2.49229420
48Biconcave vertebral bodies (HP:0004586)2.48011858
49Rectal prolapse (HP:0002035)2.47903682
50Dilated cardiomyopathy (HP:0001644)2.46849633
51Exercise-induced muscle cramps (HP:0003710)2.43697159
52Abnormality of skeletal muscle fiber size (HP:0012084)2.43310305
53Short nail (HP:0001799)2.41027151
54Slender build (HP:0001533)2.40779856
55Prolonged QT interval (HP:0001657)2.34721620
56Atrophic scars (HP:0001075)2.34402759
57Abnormality of the acetabulum (HP:0003170)2.33810185
58Cervical subluxation (HP:0003308)2.32606825
59Hypoplasia of the iris (HP:0007676)2.28619053
60Follicular hyperkeratosis (HP:0007502)2.28399320
61Ulnar bowing (HP:0003031)2.25360180
62Mesangial abnormality (HP:0001966)2.24824308
63Elbow flexion contracture (HP:0002987)2.24458329
64Short 4th metacarpal (HP:0010044)2.23464929
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23464929
66Difficulty running (HP:0009046)2.20427971
67Camptodactyly of toe (HP:0001836)2.19398094
68Muscle hypertrophy of the lower extremities (HP:0008968)2.19226125
69Visceral angiomatosis (HP:0100761)2.17280650
70Subacute progressive viral hepatitis (HP:0006572)2.16872533
71Striae distensae (HP:0001065)2.16249983
72Abnormal delivery (HP:0001787)2.15731909
73Thin bony cortex (HP:0002753)2.15043782
74Mitral stenosis (HP:0001718)2.13501480
75Arterial tortuosity (HP:0005116)2.13270587
76Wormian bones (HP:0002645)2.13220835
77Joint stiffness (HP:0001387)2.12132348
78Joint laxity (HP:0001388)2.11623475
79Esophageal varix (HP:0002040)2.11010786
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.10088496
81Osteolytic defects of the hand bones (HP:0009699)2.10088496
82Ectopia lentis (HP:0001083)2.09322008
83Mitral regurgitation (HP:0001653)2.09131509
84Spondylolisthesis (HP:0003302)2.08184862
85Absent frontal sinuses (HP:0002688)2.06601926
86Pigmentary retinal degeneration (HP:0001146)2.04663936
87Mildly elevated creatine phosphokinase (HP:0008180)2.04301681
88Mild short stature (HP:0003502)2.01656529
89Cardiovascular calcification (HP:0011915)2.00817965
90Abnormality of the 4th metacarpal (HP:0010012)2.00519261
91Coronal craniosynostosis (HP:0004440)1.98562318
92Natal tooth (HP:0000695)1.98176656
93Hemangiomatosis (HP:0007461)1.97847671
94EMG: myopathic abnormalities (HP:0003458)1.95799973
95Blue sclerae (HP:0000592)1.95075970
96Ovoid vertebral bodies (HP:0003300)1.92436850
97Syncope (HP:0001279)1.91564155
98Asymmetry of the thorax (HP:0001555)1.89915108
99Reduced subcutaneous adipose tissue (HP:0003758)1.89738126
100Long eyelashes (HP:0000527)1.88438979
101Aortic regurgitation (HP:0001659)1.87950514
102Venous abnormality (HP:0002624)1.87451581
103Inguinal hernia (HP:0000023)1.87339342
104Enlarged penis (HP:0000040)1.87073669
105Myotonia (HP:0002486)1.86781073
106Hypoventilation (HP:0002791)1.86658478
107Venous insufficiency (HP:0005293)1.86090145
108Broad ribs (HP:0000885)1.84623475
109Cavernous hemangioma (HP:0001048)1.84584258
110Delayed cranial suture closure (HP:0000270)1.84112091
111Joint contractures involving the joints of the feet (HP:0100492)1.84041057
112Flexion contracture of toe (HP:0005830)1.84041057
113Hypoglycemic coma (HP:0001325)1.83692805
114Osteoarthritis (HP:0002758)1.83605986
115Disproportionate tall stature (HP:0001519)1.83371151
116Broad face (HP:0000283)1.81303772
117Hyperextensible skin (HP:0000974)1.81219141
118Abnormality of the nasal mucosa (HP:0000433)1.80399558
119Round ear (HP:0100830)1.80302981
120Coxa vara (HP:0002812)1.80133024
121Mesomelia (HP:0003027)1.79030835
122Delayed closure of the anterior fontanelle (HP:0001476)1.76349136
123Asymmetric septal hypertrophy (HP:0001670)1.76322631
124Aortic valve stenosis (HP:0001650)1.76270300
125Syringomyelia (HP:0003396)1.75860938
126Spinal cord lesions (HP:0100561)1.75860938
127Abnormality of the right ventricle (HP:0001707)1.74585073
128Protruding ear (HP:0000411)1.74180144
129Scapular winging (HP:0003691)1.73919705
130Thoracolumbar scoliosis (HP:0002944)1.73579124
131Narrow palate (HP:0000189)1.73331844
132Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72974079
133Flat cornea (HP:0007720)1.72759809
134Long toe (HP:0010511)1.72455430
135Knee flexion contracture (HP:0006380)1.72283336
136Abnormality of skull ossification (HP:0002703)1.70197431
137Persistence of primary teeth (HP:0006335)1.66169548
138Nonimmune hydrops fetalis (HP:0001790)1.65620389
139Tibial bowing (HP:0002982)1.62487868
140Upper limb amyotrophy (HP:0009129)1.60128065
141Distal upper limb amyotrophy (HP:0007149)1.60128065
142Flared iliac wings (HP:0002869)1.59789338
143Bowed forearm bones (HP:0003956)1.59759940
144Bowing of the arm (HP:0006488)1.59759940
145Cupped ribs (HP:0000887)1.58899084
146Arachnodactyly (HP:0001166)1.58809447
147Broad long bones (HP:0005622)1.58741566
148Generalized amyotrophy (HP:0003700)1.58717342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.35877471
2TGFBR23.58951739
3KDR3.20440392
4TTN3.19307704
5MYLK2.50361117
6NTRK12.47941513
7DMPK2.39695825
8TRIB32.34265211
9INSRR2.26867092
10LATS22.22903430
11EPHB22.20806066
12RIPK12.11626647
13CAMK1D2.01123505
14STK241.78095289
15PDGFRA1.75047408
16TGFBR11.73597900
17CAMK1G1.65928370
18SIK11.65230509
19PIK3CA1.59187460
20TESK11.56149843
21PKN21.55387987
22LIMK11.50132911
23MOS1.48477502
24FGFR21.44617649
25STK381.43863945
26FGFR31.40414859
27OBSCN1.40056869
28EPHB11.39010726
29ERBB41.32167744
30LMTK21.28193938
31ERN11.23340502
32PTK2B1.22321588
33LRRK21.20938441
34PTK61.18848960
35MST1R1.18573253
36ICK1.17442594
37PRKCH1.16484123
38TRPM71.14967998
39PRKD11.14631167
40PDK21.12696404
41GRK11.11999303
42PRPF4B1.11536785
43FGFR41.07101559
44LATS11.06082312
45NUAK11.06071322
46EPHA31.04819966
47RPS6KA21.03939315
48FER1.03434845
49MAP3K61.01265447
50TEC1.00490330
51PDGFRB1.00350302
52AKT30.99839115
53PIK3CG0.99418348
54MELK0.99051779
55ZAK0.95894028
56JAK10.95203425
57NLK0.94494390
58ILK0.92944591
59MAP3K30.92204365
60STK100.91701302
61JAK30.90546870
62PRKAA20.88169382
63MAP3K70.87960611
64PAK30.87902540
65STK30.87656125
66NEK90.87399887
67PAK20.86528901
68FRK0.86483583
69SMG10.85333492
70WNK10.80730789
71EEF2K0.80065900
72PDK40.77330427
73PDK30.77330427
74GRK70.76154906
75ROCK10.75642382
76MTOR0.74940045
77MAP2K30.73605096
78PAK40.71782714
79ABL20.70254214
80CDK60.69284543
81IRAK30.67185031
82EPHA20.65500568
83MAPK120.65113494
84ROCK20.63967982
85MAP3K100.63569572
86MAPK70.62748590
87BCKDK0.60005672
88CDC42BPA0.59555574
89PAK60.59486869
90PRKD30.59047050
91PHKG20.58578006
92PHKG10.58578006
93ITK0.58260454
94CDK80.57749505
95TYK20.57728567
96DDR20.56584745
97PRKG20.55798327
98CDK120.55610460
99PRKD20.55320775
100DAPK30.55047824
101PTK20.54079519
102ADRBK10.54008268
103MAP4K10.52390049
104HIPK20.50792677
105CSK0.50241596
106KIT0.50146812
107FGFR10.49354646
108STK38L0.49179045
109KSR20.48599326
110WNK40.46861320
111MAP3K130.46597625
112CAMK40.46356271
113MAP2K10.46322731
114IGF1R0.44431920
115ZAP700.43365715
116MARK20.43292085
117RPS6KL10.43103706
118RPS6KC10.43103706
119GRK50.43022992
120PIM20.42325598
121CLK10.42317783
122INSR0.42107467
123CAMK2G0.41868753
124CHUK0.41484513
125RET0.39985746
126GSK3A0.39260422
127PNCK0.39059203
128TAOK20.39017162
129FLT30.38770053
130PRKAA10.37257805
131CDK90.36681993
132MET0.36435156
133PDPK10.36292131
134PRKCE0.35512929
135SRC0.34848634
136SGK30.33308156
137MAPK40.33099638
138ARAF0.32921630
139CAMK10.32901563
140BMX0.32450915
141MAP3K80.31821399

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.28908842
2Dilated cardiomyopathy_Homo sapiens_hsa054143.02189786
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.98120715
4Focal adhesion_Homo sapiens_hsa045102.66420921
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.43899549
6Adherens junction_Homo sapiens_hsa045202.16813663
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.14101650
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.11173398
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.10600093
10Viral myocarditis_Homo sapiens_hsa054162.08727189
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.08670713
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98663430
13Small cell lung cancer_Homo sapiens_hsa052221.82313997
14Proteoglycans in cancer_Homo sapiens_hsa052051.69353928
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.58041749
16Amoebiasis_Homo sapiens_hsa051461.56378618
17Protein digestion and absorption_Homo sapiens_hsa049741.50860217
18Insulin resistance_Homo sapiens_hsa049311.48153544
19Bladder cancer_Homo sapiens_hsa052191.42639348
20Platelet activation_Homo sapiens_hsa046111.41729182
21Malaria_Homo sapiens_hsa051441.40713392
22Prion diseases_Homo sapiens_hsa050201.40390287
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39342240
24Ovarian steroidogenesis_Homo sapiens_hsa049131.37910014
25Complement and coagulation cascades_Homo sapiens_hsa046101.36848790
26Notch signaling pathway_Homo sapiens_hsa043301.33643441
27Chronic myeloid leukemia_Homo sapiens_hsa052201.29487236
28Other glycan degradation_Homo sapiens_hsa005111.29200222
29Toxoplasmosis_Homo sapiens_hsa051451.28718056
30TGF-beta signaling pathway_Homo sapiens_hsa043501.27719399
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22613016
32Lysine degradation_Homo sapiens_hsa003101.21512888
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20560239
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.19033647
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16323983
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15467583
37Propanoate metabolism_Homo sapiens_hsa006401.14011529
38Fatty acid degradation_Homo sapiens_hsa000711.12046981
39Dorso-ventral axis formation_Homo sapiens_hsa043201.11915310
40Pathways in cancer_Homo sapiens_hsa052001.11236907
41Rap1 signaling pathway_Homo sapiens_hsa040151.09669161
42MicroRNAs in cancer_Homo sapiens_hsa052061.08650666
43Hedgehog signaling pathway_Homo sapiens_hsa043401.07806892
44Fatty acid metabolism_Homo sapiens_hsa012121.07416997
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05689162
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05305426
47HIF-1 signaling pathway_Homo sapiens_hsa040661.03195973
48PPAR signaling pathway_Homo sapiens_hsa033201.02141299
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01323041
50Prostate cancer_Homo sapiens_hsa052150.99948381
51Renal cell carcinoma_Homo sapiens_hsa052110.99706684
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.97849933
53Tight junction_Homo sapiens_hsa045300.96848814
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95646543
55AMPK signaling pathway_Homo sapiens_hsa041520.94689964
56Pertussis_Homo sapiens_hsa051330.92991961
57Gap junction_Homo sapiens_hsa045400.92740484
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92199370
59Fatty acid biosynthesis_Homo sapiens_hsa000610.92064457
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91041403
61Acute myeloid leukemia_Homo sapiens_hsa052210.86986363
62Renin secretion_Homo sapiens_hsa049240.86597905
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86033930
64Pancreatic cancer_Homo sapiens_hsa052120.85491638
65HTLV-I infection_Homo sapiens_hsa051660.84285318
66cAMP signaling pathway_Homo sapiens_hsa040240.82519635
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82432757
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79934453
69Shigellosis_Homo sapiens_hsa051310.78651400
70Hippo signaling pathway_Homo sapiens_hsa043900.76219504
71Melanoma_Homo sapiens_hsa052180.75476593
72Basal cell carcinoma_Homo sapiens_hsa052170.75444701
73Insulin signaling pathway_Homo sapiens_hsa049100.75317747
74Endocytosis_Homo sapiens_hsa041440.74883331
75TNF signaling pathway_Homo sapiens_hsa046680.74503198
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74434860
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74292358
78Thyroid hormone synthesis_Homo sapiens_hsa049180.71370465
79Glucagon signaling pathway_Homo sapiens_hsa049220.71324333
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70528236
81Hematopoietic cell lineage_Homo sapiens_hsa046400.70287088
82FoxO signaling pathway_Homo sapiens_hsa040680.70237390
83Lysosome_Homo sapiens_hsa041420.69633635
84Phototransduction_Homo sapiens_hsa047440.68512885
85B cell receptor signaling pathway_Homo sapiens_hsa046620.67738973
86Starch and sucrose metabolism_Homo sapiens_hsa005000.67717733
87GnRH signaling pathway_Homo sapiens_hsa049120.67491007
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65652441
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.65321686
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63749632
91Ras signaling pathway_Homo sapiens_hsa040140.62961203
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62637140
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.62243066
94Phagosome_Homo sapiens_hsa041450.61059555
95Cardiac muscle contraction_Homo sapiens_hsa042600.60254508
96Osteoclast differentiation_Homo sapiens_hsa043800.60065280
97Type II diabetes mellitus_Homo sapiens_hsa049300.59869716
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59747971
99Endometrial cancer_Homo sapiens_hsa052130.59225406
100mTOR signaling pathway_Homo sapiens_hsa041500.59025576
101N-Glycan biosynthesis_Homo sapiens_hsa005100.58705380
102Wnt signaling pathway_Homo sapiens_hsa043100.58617241
103Axon guidance_Homo sapiens_hsa043600.58513163
104Non-small cell lung cancer_Homo sapiens_hsa052230.58135212
105Estrogen signaling pathway_Homo sapiens_hsa049150.57371489
106Glioma_Homo sapiens_hsa052140.57312273
107VEGF signaling pathway_Homo sapiens_hsa043700.57079683
108Colorectal cancer_Homo sapiens_hsa052100.56285081
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55530194
110Melanogenesis_Homo sapiens_hsa049160.53632974
111Hepatitis B_Homo sapiens_hsa051610.52866502
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.52489228
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51204990
114Prolactin signaling pathway_Homo sapiens_hsa049170.51022524
115Oxytocin signaling pathway_Homo sapiens_hsa049210.50894329
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50534478
117Circadian rhythm_Homo sapiens_hsa047100.50301759
118Thyroid cancer_Homo sapiens_hsa052160.50186766
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49703745
120Vibrio cholerae infection_Homo sapiens_hsa051100.49388007
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.49080463
122ErbB signaling pathway_Homo sapiens_hsa040120.48763454
123Choline metabolism in cancer_Homo sapiens_hsa052310.47928235
124Apoptosis_Homo sapiens_hsa042100.47632862
125Galactose metabolism_Homo sapiens_hsa000520.47092822
126MAPK signaling pathway_Homo sapiens_hsa040100.46521103
127Salmonella infection_Homo sapiens_hsa051320.46411475
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45016015
129Hepatitis C_Homo sapiens_hsa051600.44376037
130Leishmaniasis_Homo sapiens_hsa051400.44042174
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.43917922
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.43681481

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