HELB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.72688707
2nuclear pore organization (GO:0006999)4.64324262
3DNA unwinding involved in DNA replication (GO:0006268)4.42000396
4protein localization to kinetochore (GO:0034501)4.41787200
5protein K11-linked deubiquitination (GO:0035871)4.28164789
6monoubiquitinated protein deubiquitination (GO:0035520)4.15541744
7indolalkylamine metabolic process (GO:0006586)4.13922034
8DNA replication initiation (GO:0006270)4.07970844
9folic acid-containing compound biosynthetic process (GO:0009396)4.04800811
10indole-containing compound catabolic process (GO:0042436)3.98314629
11indolalkylamine catabolic process (GO:0046218)3.98314629
12tryptophan catabolic process (GO:0006569)3.98314629
13regulation of B cell receptor signaling pathway (GO:0050855)3.98113289
14neural tube formation (GO:0001841)3.89533934
15protein K48-linked deubiquitination (GO:0071108)3.87978712
16regulation of histone H3-K9 methylation (GO:0051570)3.86821627
17activated T cell proliferation (GO:0050798)3.86150918
18mitotic nuclear envelope disassembly (GO:0007077)3.83521712
19DNA strand elongation involved in DNA replication (GO:0006271)3.80912384
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76802366
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.76802366
22regulation of translation, ncRNA-mediated (GO:0045974)3.76802366
23protein localization to chromosome, centromeric region (GO:0071459)3.71776321
24positive regulation of developmental pigmentation (GO:0048087)3.70771271
25pore complex assembly (GO:0046931)3.69660781
26DNA strand elongation (GO:0022616)3.63142486
27negative regulation of histone methylation (GO:0031061)3.61732612
28positive regulation of gamma-delta T cell activation (GO:0046645)3.61111737
29mitotic chromosome condensation (GO:0007076)3.60594152
30signal peptide processing (GO:0006465)3.58663436
31kynurenine metabolic process (GO:0070189)3.58378218
32telomere maintenance via semi-conservative replication (GO:0032201)3.57859347
33* DNA duplex unwinding (GO:0032508)3.57355340
34L-fucose catabolic process (GO:0042355)3.57323592
35fucose catabolic process (GO:0019317)3.57323592
36L-fucose metabolic process (GO:0042354)3.57323592
37* DNA geometric change (GO:0032392)3.57200720
38DNA replication-dependent nucleosome assembly (GO:0006335)3.55896918
39DNA replication-dependent nucleosome organization (GO:0034723)3.55896918
40nuclear envelope disassembly (GO:0051081)3.53137783
41membrane disassembly (GO:0030397)3.53137783
42tryptophan metabolic process (GO:0006568)3.51446811
43DNA replication checkpoint (GO:0000076)3.47880801
44mitotic sister chromatid segregation (GO:0000070)3.46473304
45behavioral response to nicotine (GO:0035095)3.46149678
46establishment of protein localization to Golgi (GO:0072600)3.45230371
47protein K63-linked deubiquitination (GO:0070536)3.45150394
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.44795167
49sister chromatid segregation (GO:0000819)3.43900794
50IMP biosynthetic process (GO:0006188)3.43821255
51negative T cell selection (GO:0043383)3.40640608
52dosage compensation (GO:0007549)3.36652910
53cellular response to ethanol (GO:0071361)3.35232313
54telomere maintenance via recombination (GO:0000722)3.32553619
55interkinetic nuclear migration (GO:0022027)3.30020719
56mitotic recombination (GO:0006312)3.28907270
57positive regulation of chromosome segregation (GO:0051984)3.28834552
58interferon-gamma production (GO:0032609)3.25726834
59mitotic sister chromatid cohesion (GO:0007064)3.23858866
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23399516
61regulation of gamma-delta T cell differentiation (GO:0045586)3.23031660
62negative thymic T cell selection (GO:0045060)3.21464609
63mitotic metaphase plate congression (GO:0007080)3.18357776
64positive regulation of granulocyte differentiation (GO:0030854)3.17783934
65heterochromatin organization (GO:0070828)3.16731990
66kinetochore organization (GO:0051383)3.16218291
67chromatin assembly (GO:0031497)3.15893424
68ribosomal small subunit assembly (GO:0000028)3.15545436
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14467255
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.14467255
71regulation of gamma-delta T cell activation (GO:0046643)3.13320042
72regulation of pigment cell differentiation (GO:0050932)3.13234690
73regulation of gene silencing by RNA (GO:0060966)3.11867688
74regulation of posttranscriptional gene silencing (GO:0060147)3.11867688
75regulation of gene silencing by miRNA (GO:0060964)3.11867688
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09486549
77rRNA catabolic process (GO:0016075)3.06705135
78regulation of hippo signaling (GO:0035330)3.04451559
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04398936
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04398936
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.04398936
82IMP metabolic process (GO:0046040)3.04367074
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03570679
84regulation of helicase activity (GO:0051095)3.03125027
85determination of adult lifespan (GO:0008340)3.02383904
86regulation of spindle organization (GO:0090224)3.00102293
87meiotic chromosome segregation (GO:0045132)2.98731837
88regulation of translational fidelity (GO:0006450)2.97281130
89cilium or flagellum-dependent cell motility (GO:0001539)2.95820797
90regulation of mitotic spindle organization (GO:0060236)2.94863761
91regulation of establishment of cell polarity (GO:2000114)2.92745555
92telomere maintenance via telomere lengthening (GO:0010833)2.91561114
93metaphase plate congression (GO:0051310)2.91533980
94cellular response to interleukin-15 (GO:0071350)2.90278291
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88998613
96nucleobase biosynthetic process (GO:0046112)2.88777287
97chromatin assembly or disassembly (GO:0006333)2.88176799
98DNA deamination (GO:0045006)2.86515748
99regulation of gene silencing (GO:0060968)2.85851053
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.85539075
101indole-containing compound metabolic process (GO:0042430)2.85218576
102* DNA conformation change (GO:0071103)2.85210509
103viral transcription (GO:0019083)2.84889772
104negative regulation of cAMP-mediated signaling (GO:0043951)2.83214559
105translational termination (GO:0006415)2.81994191
106detection of light stimulus involved in sensory perception (GO:0050962)2.81137175
107detection of light stimulus involved in visual perception (GO:0050908)2.81137175
108pre-miRNA processing (GO:0031054)2.80849952
109formation of translation preinitiation complex (GO:0001731)2.80638472
110negative regulation of T cell mediated immunity (GO:0002710)2.80511113
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79298799
112protein K6-linked ubiquitination (GO:0085020)2.79189081
113regulation of MHC class I biosynthetic process (GO:0045343)2.78603777
114NAD biosynthetic process (GO:0009435)2.78528232
115maturation of SSU-rRNA (GO:0030490)2.78362141
116snRNA transcription (GO:0009301)2.78353001
117histone H3-K9 methylation (GO:0051567)2.77627911
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77497389
119positive regulation of defense response to virus by host (GO:0002230)2.75757640
120nuclear envelope organization (GO:0006998)2.75705692
121chromatin remodeling at centromere (GO:0031055)2.75691105
122translesion synthesis (GO:0019985)2.74874632
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.74667741
124regulation of sister chromatid cohesion (GO:0007063)2.74055354
125response to interleukin-15 (GO:0070672)2.73736980
126telomere maintenance (GO:0000723)2.73645925
127positive T cell selection (GO:0043368)2.73341761
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72176803
129negative regulation of cell killing (GO:0031342)2.72176803
130telomere organization (GO:0032200)2.71404569
131tolerance induction (GO:0002507)2.69825364
132attachment of spindle microtubules to kinetochore (GO:0008608)2.69497031
133regulation of DNA endoreduplication (GO:0032875)2.68138026
134tetrahydrofolate metabolic process (GO:0046653)2.67976506
135establishment of chromosome localization (GO:0051303)2.67708586
136protein localization to chromosome (GO:0034502)2.66954171
137DNA replication-independent nucleosome assembly (GO:0006336)2.66821413
138DNA replication-independent nucleosome organization (GO:0034724)2.66821413
139hepatocyte apoptotic process (GO:0097284)2.66292008
140histone mRNA catabolic process (GO:0071044)2.66077615
141histone H3-K4 trimethylation (GO:0080182)2.65570154
142histone-serine phosphorylation (GO:0035404)2.64859193
143regulation of interleukin-12 biosynthetic process (GO:0045075)2.64711413
144replicative senescence (GO:0090399)2.64601738
145CENP-A containing nucleosome assembly (GO:0034080)2.62866392
146regulation of chromatin silencing (GO:0031935)2.61853097
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61389164
148reciprocal meiotic recombination (GO:0007131)2.60719666
149reciprocal DNA recombination (GO:0035825)2.60719666
150nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59893194
151histone H3-K9 modification (GO:0061647)2.58222616
152response to pheromone (GO:0019236)2.57937830
153kinetochore assembly (GO:0051382)2.57488593
154regulation of translational termination (GO:0006449)2.57369310
155regulation of RNA export from nucleus (GO:0046831)2.56773633
156mismatch repair (GO:0006298)2.56499315
157purine nucleobase biosynthetic process (GO:0009113)2.55400624
158ribosomal small subunit biogenesis (GO:0042274)2.55222183
159response to UV-C (GO:0010225)2.54291237
160negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53843417
161protein targeting to Golgi (GO:0000042)2.52584260
162regulation of memory T cell differentiation (GO:0043380)2.52146475
163regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51699535
164translational elongation (GO:0006414)2.50990185
165reflex (GO:0060004)2.50854233
166negative regulation of gene silencing (GO:0060969)2.50731355
167epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49678888
168regulation of MHC class II biosynthetic process (GO:0045346)2.49626378
169lipid translocation (GO:0034204)2.49414630
170phospholipid translocation (GO:0045332)2.49414630
171DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.48538210
172regulation of establishment or maintenance of cell polarity (GO:0032878)2.48438644
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.48300752
174positive regulation of mRNA catabolic process (GO:0061014)2.47927251
175photoreceptor cell maintenance (GO:0045494)2.47843088
176translational initiation (GO:0006413)2.47816457
177chromosome segregation (GO:0007059)2.47512401
178negative regulation of interleukin-1 beta production (GO:0032691)2.46414955
179mitotic G1 DNA damage checkpoint (GO:0031571)2.46051639
180negative regulation of interleukin-1 production (GO:0032692)2.45484700
181antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45381790
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45381790
183cAMP catabolic process (GO:0006198)2.45076214
184serotonin metabolic process (GO:0042428)2.45001730
185double-strand break repair via homologous recombination (GO:0000724)2.44538153
186sulfation (GO:0051923)2.44026400
187regulation of regulatory T cell differentiation (GO:0045589)2.43794161
188T cell migration (GO:0072678)2.42664378
189recombinational repair (GO:0000725)2.42194780
190cytoplasmic mRNA processing body assembly (GO:0033962)2.41189618
191alpha-beta T cell differentiation (GO:0046632)2.39466869
192mast cell activation (GO:0045576)2.38586577
193purinergic nucleotide receptor signaling pathway (GO:0035590)2.37378135
194cellular biogenic amine catabolic process (GO:0042402)2.36254491
195amine catabolic process (GO:0009310)2.36254491
196negative regulation of lymphocyte mediated immunity (GO:0002707)2.35155417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67061647
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.48192189
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53238249
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.01691927
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.99909872
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84570983
7ZNF274_21170338_ChIP-Seq_K562_Hela2.81140810
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75005783
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71923866
10VDR_22108803_ChIP-Seq_LS180_Human2.69088900
11GBX2_23144817_ChIP-Seq_PC3_Human2.57745664
12MYC_22102868_ChIP-Seq_BL_Human2.41532514
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.39916574
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33311509
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26467248
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25599524
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25001624
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23664795
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23086693
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08448531
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05660173
22IGF1R_20145208_ChIP-Seq_DFB_Human2.04316818
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02732712
24TAF15_26573619_Chip-Seq_HEK293_Human2.01037585
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.00014216
26ER_23166858_ChIP-Seq_MCF-7_Human1.96398463
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89797355
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88958466
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88758273
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87037511
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86705519
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86534852
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79840901
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.79492014
35EWS_26573619_Chip-Seq_HEK293_Human1.79147534
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77681534
37STAT3_23295773_ChIP-Seq_U87_Human1.75539350
38P300_19829295_ChIP-Seq_ESCs_Human1.74787904
39RUNX_20019798_ChIP-Seq_JUKART_Human1.73958036
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71362626
41AR_21909140_ChIP-Seq_LNCAP_Human1.71231185
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70487243
43* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70235299
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69597305
45AR_21572438_ChIP-Seq_LNCaP_Human1.69383592
46VDR_21846776_ChIP-Seq_THP-1_Human1.68019127
47FUS_26573619_Chip-Seq_HEK293_Human1.65806528
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.62695156
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.60405501
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60255884
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60147526
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58825933
53XRN2_22483619_ChIP-Seq_HELA_Human1.57737592
54* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54086333
55BCAT_22108803_ChIP-Seq_LS180_Human1.53555255
56TCF4_23295773_ChIP-Seq_U87_Human1.53552815
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53476178
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53290390
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53067549
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53067549
61VDR_23849224_ChIP-Seq_CD4+_Human1.52795464
62EZH2_22144423_ChIP-Seq_EOC_Human1.50931901
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49613680
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.49227363
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49021840
66CIITA_25753668_ChIP-Seq_RAJI_Human1.47405956
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47393832
68FOXP3_21729870_ChIP-Seq_TREG_Human1.47207842
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46090232
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45853169
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45399981
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43828156
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.41925476
74SMAD4_21799915_ChIP-Seq_A2780_Human1.41706091
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.41651128
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41089881
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40982955
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40660952
79GATA3_26560356_Chip-Seq_TH2_Human1.40393886
80TP53_16413492_ChIP-PET_HCT116_Human1.39518788
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.38927060
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.38594985
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38405977
84* IRF8_21731497_ChIP-ChIP_J774_Mouse1.37453658
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36731843
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36731843
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36731843
88* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36715735
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.35609401
90* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34710059
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33477696
92CBP_20019798_ChIP-Seq_JUKART_Human1.32488147
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32488147
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32136992
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31484842
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.31070961
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30725017
98IRF1_19129219_ChIP-ChIP_H3396_Human1.30319855
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28949301
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27441059
101GATA1_22025678_ChIP-Seq_K562_Human1.26068992
102KDM5A_27292631_Chip-Seq_BREAST_Human1.25576307
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25525272
104AR_25329375_ChIP-Seq_VCAP_Human1.24779658
105TFEB_21752829_ChIP-Seq_HELA_Human1.24283159
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.23173217
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22768771
108SCL_19346495_ChIP-Seq_HPC-7_Human1.22459694
109MYB_26560356_Chip-Seq_TH1_Human1.22234600
110TCF4_22108803_ChIP-Seq_LS180_Human1.21909887
111MAF_26560356_Chip-Seq_TH1_Human1.20192077
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20092374
113* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19634598
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19463030
115ELK1_19687146_ChIP-ChIP_HELA_Human1.18913683
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18815309
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18777264
118* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17729316
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17620681
120MYB_26560356_Chip-Seq_TH2_Human1.17348663
121* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16935512
122SPI1_23547873_ChIP-Seq_NB4_Human1.16797582
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16630478
124UTX_26944678_Chip-Seq_JUKART_Human1.14827696
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14193004
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14188222
127RUNX2_22187159_ChIP-Seq_PCA_Human1.13905045
128* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13205179
129DCP1A_22483619_ChIP-Seq_HELA_Human1.12929657
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.12027149
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11559067
132* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11522822
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11099911
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10989189
135* GATA3_27048872_Chip-Seq_THYMUS_Human1.10692923
136ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10545651
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10067059
138TP53_22573176_ChIP-Seq_HFKS_Human1.09883116
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09877183
140TCF7_22412390_ChIP-Seq_EML_Mouse1.09257627
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08638242
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08238421
143NANOG_18555785_Chip-Seq_ESCs_Mouse1.08229411
144* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07492160
145HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07154339
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06599956
147EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06463637
148* SMAD4_21741376_ChIP-Seq_EPCs_Human1.06131385
149ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05653024
150NANOG_19829295_ChIP-Seq_ESCs_Human1.05269357
151SOX2_19829295_ChIP-Seq_ESCs_Human1.05269357
152TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04826730
153* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04798789
154ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04493727
155VDR_24787735_ChIP-Seq_THP-1_Human1.04288892
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04105189
157TTF2_22483619_ChIP-Seq_HELA_Human1.04061829
158P53_22387025_ChIP-Seq_ESCs_Mouse1.03652203
159ARNT_22903824_ChIP-Seq_MCF-7_Human1.03624224
160GABP_19822575_ChIP-Seq_HepG2_Human1.03533760
161RUNX1_22412390_ChIP-Seq_EML_Mouse1.03512866
162* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02981098
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02799957
164CDX2_22108803_ChIP-Seq_LS180_Human1.02552529
165STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02529511
166* SMRT_27268052_Chip-Seq_Bcells_Human1.02354682
167FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01721297
168E2F1_18555785_Chip-Seq_ESCs_Mouse1.01118410
169FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00065152
170FOXA1_25329375_ChIP-Seq_VCAP_Human1.00065152
171KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99901266
172KDM2B_26808549_Chip-Seq_REH_Human0.99834378
173TP63_19390658_ChIP-ChIP_HaCaT_Human0.99746949
174FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98520495
175* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98135229
176DROSHA_22980978_ChIP-Seq_HELA_Human0.97852750
177STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97718084
178DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96158556
179PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94411176
180TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92704935
181* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91662346
182STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90717515
183MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90569000
184KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90350876
185E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89986125
186THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89842435
187NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89838812
188CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89123124
189GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87672009
190GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86773279
191TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86073894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.26619591
2MP0010094_abnormal_chromosome_stability3.65784541
3MP0003693_abnormal_embryo_hatching3.60559683
4MP0008057_abnormal_DNA_replication3.45489723
5MP0003111_abnormal_nucleus_morphology3.42911631
6MP0003077_abnormal_cell_cycle3.05827467
7MP0003195_calcinosis2.95210236
8MP0004957_abnormal_blastocyst_morpholog2.92619788
9MP0010352_gastrointestinal_tract_polyps2.76420134
10MP0010307_abnormal_tumor_latency2.71288108
11MP0003646_muscle_fatigue2.65947150
12MP0002396_abnormal_hematopoietic_system2.63178376
13MP0003787_abnormal_imprinting2.27799940
14MP0008058_abnormal_DNA_repair2.23835294
15MP0003724_increased_susceptibility_to2.12185413
16MP0005076_abnormal_cell_differentiation1.95654526
17MP0001501_abnormal_sleep_pattern1.93020653
18MP0005310_abnormal_salivary_gland1.92336030
19MP0000350_abnormal_cell_proliferation1.88359590
20MP0003806_abnormal_nucleotide_metabolis1.87516867
21MP0001730_embryonic_growth_arrest1.82500833
22MP0002102_abnormal_ear_morphology1.79731333
23MP0000490_abnormal_crypts_of1.77651664
24MP0004043_abnormal_pH_regulation1.76775024
25MP0005551_abnormal_eye_electrophysiolog1.76348034
26MP0004381_abnormal_hair_follicle1.75699181
27MP0008007_abnormal_cellular_replicative1.73626825
28MP0004808_abnormal_hematopoietic_stem1.72438417
29MP0003763_abnormal_thymus_physiology1.71604516
30MP0003705_abnormal_hypodermis_morpholog1.65903337
31MP0000427_abnormal_hair_cycle1.64853477
32MP0002398_abnormal_bone_marrow1.64271210
33MP0001800_abnormal_humoral_immune1.60739310
34MP0004130_abnormal_muscle_cell1.59512841
35MP0005397_hematopoietic_system_phenotyp1.58974854
36MP0001545_abnormal_hematopoietic_system1.58974854
37MP0002009_preneoplasia1.52766640
38MP0009278_abnormal_bone_marrow1.52520827
39MP0001835_abnormal_antigen_presentation1.52226268
40MP0000703_abnormal_thymus_morphology1.50920790
41MP0002722_abnormal_immune_system1.50634216
42MP0001672_abnormal_embryogenesis/_devel1.50211433
43MP0005380_embryogenesis_phenotype1.50211433
44MP0000689_abnormal_spleen_morphology1.50093200
45MP0002019_abnormal_tumor_incidence1.49130625
46MP0002166_altered_tumor_susceptibility1.48414433
47MP0000015_abnormal_ear_pigmentation1.47961707
48MP0008872_abnormal_physiological_respon1.46537289
49MP0003045_fibrosis1.45452477
50MP0003566_abnormal_cell_adhesion1.42342523
51MP0004142_abnormal_muscle_tone1.41946527
52MP0002086_abnormal_extraembryonic_tissu1.41144524
53MP0008961_abnormal_basal_metabolism1.40673316
54MP0002138_abnormal_hepatobiliary_system1.38905170
55MP0002876_abnormal_thyroid_physiology1.38435778
56MP0004197_abnormal_fetal_growth/weight/1.38067332
57MP0003984_embryonic_growth_retardation1.37947903
58MP0002088_abnormal_embryonic_growth/wei1.36505039
59MP0008932_abnormal_embryonic_tissue1.35777575
60MP0009046_muscle_twitch1.34297106
61MP0001986_abnormal_taste_sensitivity1.33313426
62MP0009333_abnormal_splenocyte_physiolog1.32313070
63MP0001697_abnormal_embryo_size1.31018486
64MP0003300_gastrointestinal_ulcer1.30760033
65MP0000685_abnormal_immune_system1.30242242
66MP0003436_decreased_susceptibility_to1.29685202
67MP0002452_abnormal_antigen_presenting1.29374971
68MP0002006_tumorigenesis1.27046714
69MP0002080_prenatal_lethality1.26089205
70MP0000716_abnormal_immune_system1.25948670
71MP0002429_abnormal_blood_cell1.24989635
72MP0000383_abnormal_hair_follicle1.24790979
73MP0000313_abnormal_cell_death1.24480690
74MP0002928_abnormal_bile_duct1.19969196
75MP0002420_abnormal_adaptive_immunity1.19783812
76MP0005023_abnormal_wound_healing1.18814359
77MP0002084_abnormal_developmental_patter1.18180482
78MP0001968_abnormal_touch/_nociception1.18062135
79MP0001819_abnormal_immune_cell1.17933315
80MP0002085_abnormal_embryonic_tissue1.15973539
81MP0005167_abnormal_blood-brain_barrier1.15293475
82MP0000372_irregular_coat_pigmentation1.14831102
83MP0005253_abnormal_eye_physiology1.14412300
84MP0002723_abnormal_immune_serum1.14135371
85MP0009764_decreased_sensitivity_to1.13625519
86MP0003786_premature_aging1.11323834
87MP0005671_abnormal_response_to1.11123835
88MP0005645_abnormal_hypothalamus_physiol1.10487804
89MP0002148_abnormal_hypersensitivity_rea1.09149112
90MP0001790_abnormal_immune_system1.09121555
91MP0005387_immune_system_phenotype1.09121555
92MP0000858_altered_metastatic_potential1.09064411
93MP0003303_peritoneal_inflammation1.08686086
94MP0003866_abnormal_defecation1.06864487
95MP0009745_abnormal_behavioral_response1.06826768
96MP0008877_abnormal_DNA_methylation1.06804017
97MP0005646_abnormal_pituitary_gland1.06527576
98MP0010155_abnormal_intestine_physiology1.06422408
99MP0002095_abnormal_skin_pigmentation1.02250521
100MP0005464_abnormal_platelet_physiology1.01964532
101MP0002405_respiratory_system_inflammati1.01121828
102MP0005266_abnormal_metabolism1.00858888
103MP0001915_intracranial_hemorrhage1.00485310
104MP0002693_abnormal_pancreas_physiology1.00223823
105MP0005000_abnormal_immune_tolerance1.00043088
106MP0001485_abnormal_pinna_reflex0.98638798
107MP0005025_abnormal_response_to0.97350119
108MP0003567_abnormal_fetal_cardiomyocyte0.97198334
109MP0002837_dystrophic_cardiac_calcinosis0.95475157
110MP0002877_abnormal_melanocyte_morpholog0.94062986
111MP0005075_abnormal_melanosome_morpholog0.93462788
112MP0001919_abnormal_reproductive_system0.93129697
113MP0005389_reproductive_system_phenotype0.92464291
114MP0004947_skin_inflammation0.90911108
115MP0006082_CNS_inflammation0.90038996
116MP0003136_yellow_coat_color0.89649935
117MP0002168_other_aberrant_phenotype0.89481442
118MP0000371_diluted_coat_color0.88992778
119MP0003448_altered_tumor_morphology0.88911182
120MP0001873_stomach_inflammation0.87438621
121MP0003656_abnormal_erythrocyte_physiolo0.87020299
122MP0000465_gastrointestinal_hemorrhage0.85508930
123MP0001849_ear_inflammation0.85251227
124MP0009840_abnormal_foam_cell0.85048050
125MP0010386_abnormal_urinary_bladder0.84789220
126MP0001853_heart_inflammation0.84542373
127MP0010234_abnormal_vibrissa_follicle0.83038039
128MP0002419_abnormal_innate_immunity0.82686110
129MP0002277_abnormal_respiratory_mucosa0.82535093
130MP0002638_abnormal_pupillary_reflex0.82499171
131MP0000230_abnormal_systemic_arterial0.82117813
132MP0004742_abnormal_vestibular_system0.81413448
133MP0005621_abnormal_cell_physiology0.79790121
134MP0005448_abnormal_energy_balance0.79636484
135MP0004924_abnormal_behavior0.79441642
136MP0005386_behavior/neurological_phenoty0.79441642
137MP0003453_abnormal_keratinocyte_physiol0.79206888
138MP0005377_hearing/vestibular/ear_phenot0.79185890
139MP0003878_abnormal_ear_physiology0.79185890
140MP0003890_abnormal_embryonic-extraembry0.78772123
141MP0003252_abnormal_bile_duct0.77569727
142MP0004264_abnormal_extraembryonic_tissu0.77006778
143MP0004185_abnormal_adipocyte_glucose0.76683287
144MP0004484_altered_response_of0.76282666
145MP0000477_abnormal_intestine_morphology0.75976527
146MP0001293_anophthalmia0.75761060
147MP0001845_abnormal_inflammatory_respons0.74908205
148MP0006054_spinal_hemorrhage0.74460341
149MP0000598_abnormal_liver_morphology0.74130975
150MP0002067_abnormal_sensory_capabilities0.72533741
151MP0000470_abnormal_stomach_morphology0.72015479
152MP0004147_increased_porphyrin_level0.71868257
153MP0008995_early_reproductive_senescence0.71263772
154MP0001486_abnormal_startle_reflex0.70508453
155MP0005384_cellular_phenotype0.69998771
156MP0001324_abnormal_eye_pigmentation0.69709671
157MP0005174_abnormal_tail_pigmentation0.69669445
158MP0002735_abnormal_chemical_nociception0.69121069
159MP0000609_abnormal_liver_physiology0.68692709
160MP0009785_altered_susceptibility_to0.68672789
161MP0009703_decreased_birth_body0.68475570
162MP0000733_abnormal_muscle_development0.67527575
163MP0009672_abnormal_birth_weight0.67327739
164MP0005501_abnormal_skin_physiology0.65855256

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.24321560
2Chromsome breakage (HP:0040012)3.98887044
3Genetic anticipation (HP:0003743)3.95797905
4Ependymoma (HP:0002888)3.78163034
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75777826
6Congenital stationary night blindness (HP:0007642)3.69688705
7Hyperventilation (HP:0002883)3.45935417
8Pancreatic fibrosis (HP:0100732)3.42116489
9Reticulocytopenia (HP:0001896)3.36361708
10Gaze-evoked nystagmus (HP:0000640)3.33771048
11Birth length less than 3rd percentile (HP:0003561)3.31758047
12True hermaphroditism (HP:0010459)3.26660253
13Abnormality of midbrain morphology (HP:0002418)3.21837061
14Molar tooth sign on MRI (HP:0002419)3.21837061
15Abnormality of the renal cortex (HP:0011035)3.19902106
16Stomatitis (HP:0010280)3.13282216
17Attenuation of retinal blood vessels (HP:0007843)3.12006744
18Abnormality of the fingertips (HP:0001211)3.10007742
19Clumsiness (HP:0002312)3.09607815
20Protruding tongue (HP:0010808)3.08636228
21Abnormality of chromosome stability (HP:0003220)3.07750124
22Agnosia (HP:0010524)3.03698501
23Chronic hepatic failure (HP:0100626)3.02513234
24Progressive cerebellar ataxia (HP:0002073)3.02231998
25Medulloblastoma (HP:0002885)2.95024203
26Stomach cancer (HP:0012126)2.94419325
27Basal cell carcinoma (HP:0002671)2.86211773
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81569775
29IgM deficiency (HP:0002850)2.74850060
30Rhabdomyosarcoma (HP:0002859)2.73440465
31Fair hair (HP:0002286)2.71050348
32Nephronophthisis (HP:0000090)2.69034221
33Abnormality of the renal medulla (HP:0100957)2.67379594
34T lymphocytopenia (HP:0005403)2.64813018
35Optic neuritis (HP:0100653)2.60971731
36Retrobulbar optic neuritis (HP:0100654)2.60971731
37Myelodysplasia (HP:0002863)2.59896489
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.57705973
39Impulsivity (HP:0100710)2.57196233
40Abnormality of the astrocytes (HP:0100707)2.55443072
41Astrocytoma (HP:0009592)2.55443072
42Thyroiditis (HP:0100646)2.55231722
43Progressive inability to walk (HP:0002505)2.53743682
44Recurrent viral infections (HP:0004429)2.53506750
45Selective tooth agenesis (HP:0001592)2.49622030
46Prominent nose (HP:0000448)2.48511257
47Volvulus (HP:0002580)2.48142313
48Amaurosis fugax (HP:0100576)2.48097662
49Abolished electroretinogram (ERG) (HP:0000550)2.47893521
50Thrombocytosis (HP:0001894)2.46009337
51Inability to walk (HP:0002540)2.45697411
52Decreased circulating renin level (HP:0003351)2.42310983
53Abnormality of T cell number (HP:0011839)2.41608253
54Widely spaced teeth (HP:0000687)2.41432820
55Cystic liver disease (HP:0006706)2.40921618
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.39603469
57Abnormality of the preputium (HP:0100587)2.38823539
58Abnormality of pyrimidine metabolism (HP:0004353)2.37745519
59Neoplasm of the oral cavity (HP:0100649)2.36532189
60Large for gestational age (HP:0001520)2.35040566
61Medial flaring of the eyebrow (HP:0010747)2.31701537
62Ectopic kidney (HP:0000086)2.31232357
63Meckel diverticulum (HP:0002245)2.28655946
64Glioma (HP:0009733)2.27415545
65Type II lissencephaly (HP:0007260)2.26791751
66Febrile seizures (HP:0002373)2.26752430
67IgG deficiency (HP:0004315)2.26564499
68Generalized hypopigmentation of hair (HP:0011358)2.25862717
69Hypochromic microcytic anemia (HP:0004840)2.25514397
70Absent thumb (HP:0009777)2.25228027
71Biliary tract neoplasm (HP:0100574)2.25223860
72Cafe-au-lait spot (HP:0000957)2.24457459
73Lymphoma (HP:0002665)2.22163003
74Abnormality of T cells (HP:0002843)2.21132911
75Abnormality of the ileum (HP:0001549)2.20842106
76Recurrent cutaneous fungal infections (HP:0011370)2.19444658
77Chronic mucocutaneous candidiasis (HP:0002728)2.19444658
78Elevated erythrocyte sedimentation rate (HP:0003565)2.19373823
79Myositis (HP:0100614)2.18414298
80Abnormality of alanine metabolism (HP:0010916)2.17132826
81Hyperalaninemia (HP:0003348)2.17132826
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17132826
83Breast hypoplasia (HP:0003187)2.16280805
84Cellulitis (HP:0100658)2.16120796
85Neoplasm of striated muscle (HP:0009728)2.15604302
86High pitched voice (HP:0001620)2.12601744
87Proximal placement of thumb (HP:0009623)2.12561113
88Orchitis (HP:0100796)2.10437259
89Decreased central vision (HP:0007663)2.09810110
90Patellar aplasia (HP:0006443)2.09462077
91Abnormality of DNA repair (HP:0003254)2.09285103
92Renal cortical cysts (HP:0000803)2.08142857
93Severe combined immunodeficiency (HP:0004430)2.07703638
94Deviation of the thumb (HP:0009603)2.07559050
95Abnormal drinking behavior (HP:0030082)2.07388831
96Polydipsia (HP:0001959)2.07388831
97Abnormality of cells of the erythroid lineage (HP:0012130)2.05978429
98Squamous cell carcinoma (HP:0002860)2.05218988
99Colon cancer (HP:0003003)2.05144163
100Tubular atrophy (HP:0000092)2.05132142
101Furrowed tongue (HP:0000221)2.04644585
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.04445217
103Recurrent fungal infections (HP:0002841)2.04192196
104Duplicated collecting system (HP:0000081)2.04002968
105Hypochromic anemia (HP:0001931)2.03740863
106Abnormality of reticulocytes (HP:0004312)2.03394372
107Recurrent bronchitis (HP:0002837)2.02348267
108Bone marrow hypocellularity (HP:0005528)2.01901339
109Abnormality of the labia minora (HP:0012880)2.00106087
110Abnormality of eosinophils (HP:0001879)1.99989910
111Encephalitis (HP:0002383)1.99188684
112Broad-based gait (HP:0002136)1.98997385
113Long eyelashes (HP:0000527)1.97241285
114Abnormal platelet volume (HP:0011876)1.96907307
115Pustule (HP:0200039)1.95757906
116Keratoconjunctivitis (HP:0001096)1.95451963
117Clubbing of toes (HP:0100760)1.93608556
118Absent speech (HP:0001344)1.93515732
119Leukopenia (HP:0001882)1.93443910
120Cerebellar dysplasia (HP:0007033)1.93133019
121Abnormality of B cell number (HP:0010975)1.92837869
122B lymphocytopenia (HP:0010976)1.92837869
123Oral leukoplakia (HP:0002745)1.92543303
124IgA deficiency (HP:0002720)1.92239412
125Abnormality of the pons (HP:0007361)1.92099756
126Autoimmune hemolytic anemia (HP:0001890)1.90258198
127Congenital sensorineural hearing impairment (HP:0008527)1.89272539
128Bony spicule pigmentary retinopathy (HP:0007737)1.88155024
129Duodenal stenosis (HP:0100867)1.88060871
130Small intestinal stenosis (HP:0012848)1.88060871
131Constricted visual fields (HP:0001133)1.87463869
132Increased nuchal translucency (HP:0010880)1.86738763
133Abnormal number of erythroid precursors (HP:0012131)1.86144632
134Pallor (HP:0000980)1.85564064
135Congenital hepatic fibrosis (HP:0002612)1.85154971
136Increased cerebral lipofuscin (HP:0011813)1.84713823
137Aplasia/Hypoplasia of the patella (HP:0006498)1.84128354
138Combined immunodeficiency (HP:0005387)1.83380746
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83363393
140Malignant gastrointestinal tract tumors (HP:0006749)1.82425116
141Gastrointestinal carcinoma (HP:0002672)1.82425116
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.81442260
143Absent/shortened dynein arms (HP:0200106)1.81442260
144Abnormal number of incisors (HP:0011064)1.80931475
145Neoplasm of the pancreas (HP:0002894)1.80753764
146Hypoplasia of the pons (HP:0012110)1.80250849
147Sloping forehead (HP:0000340)1.79295146
148Chorioretinal atrophy (HP:0000533)1.78989174
149Eosinophilia (HP:0001880)1.78840095
150Spastic diplegia (HP:0001264)1.78798245
151Poor coordination (HP:0002370)1.78641947
152Absent radius (HP:0003974)1.78306032
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.77348091
154Abnormality of T cell physiology (HP:0011840)1.76983999
155Congenital primary aphakia (HP:0007707)1.76929109
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.76751041
157Lissencephaly (HP:0001339)1.76496632
158Poikiloderma (HP:0001029)1.75948448
159Eczematoid dermatitis (HP:0000976)1.75896534
160Recurrent bacterial skin infections (HP:0005406)1.75699947
161Keratoconjunctivitis sicca (HP:0001097)1.75415723
162Bile duct proliferation (HP:0001408)1.75365942
163Abnormal biliary tract physiology (HP:0012439)1.75365942
164Panhypogammaglobulinemia (HP:0003139)1.74234789
165Missing ribs (HP:0000921)1.73577168
166Gait imbalance (HP:0002141)1.73172985
167Abnormality of the renal collecting system (HP:0004742)1.72970596
168Abnormality of the carotid arteries (HP:0005344)1.72785796
169Hypothermia (HP:0002045)1.72685253
170Leukocytosis (HP:0001974)1.72506618
171Abnormal rod and cone electroretinograms (HP:0008323)1.70983395
172Increased mean platelet volume (HP:0011877)1.70325560
173Pendular nystagmus (HP:0012043)1.69188405
174Rib fusion (HP:0000902)1.68325196
175Sparse lateral eyebrow (HP:0005338)1.67736183
176Hypoplastic iliac wings (HP:0002866)1.67573029
177Ulnar bowing (HP:0003031)1.66871834
178Acute myeloid leukemia (HP:0004808)1.66149695
179Heterotopia (HP:0002282)1.63431982
180Cellular immunodeficiency (HP:0005374)1.63309287
181Cutaneous melanoma (HP:0012056)1.62765073
182Pseudobulbar signs (HP:0002200)1.62607376
183Facial hemangioma (HP:0000329)1.61507982
184Degeneration of anterior horn cells (HP:0002398)1.61389928
185Abnormality of the anterior horn cell (HP:0006802)1.61389928
186Tracheoesophageal fistula (HP:0002575)1.60657748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.45489359
2CDK124.11463999
3CDC73.64281425
4BMPR1B3.44859128
5EEF2K2.93782704
6WEE12.62278607
7NEK22.61287359
8MAP4K12.56940671
9ADRBK22.46429884
10MAP3K102.36388978
11STK102.23626294
12RPS6KB21.97216162
13TTK1.97010920
14PKN21.88271147
15CDK41.72239602
16STK41.71514535
17INSRR1.67949909
18CAMKK21.66587980
19NUAK11.66519028
20NLK1.66119648
21BRD41.63835763
22PIM11.63355210
23GRK61.61867845
24FLT31.60202650
25ATR1.58907878
26TLK11.58457424
27CDK71.58023947
28PIK3CG1.51671527
29SRPK11.48955688
30EPHA21.44387501
31NEK11.43515167
32EIF2AK11.39516480
33AURKB1.38470720
34PLK11.36878068
35TNIK1.34857173
36MAP3K81.33908833
37BUB11.33871963
38GRK11.33625511
39WNK31.28689239
40JAK31.25064585
41ZAK1.24624126
42NME21.24046570
43CDK61.23836485
44IKBKE1.23288812
45MAPK131.21848903
46MAP4K21.18466035
47CHEK21.17865461
48SCYL21.17017471
49CHEK11.16572313
50TYK21.16527885
51ACVR1B1.16472376
52PASK1.15562135
53ADRBK11.15067962
54DYRK31.12237304
55TNK21.11633167
56RPS6KA41.11287375
57OXSR11.09653105
58BRSK21.08849476
59ALK1.03874491
60PTK2B1.03667327
61TSSK61.02396795
62IRAK11.00820336
63DAPK21.00019213
64ATM0.99693409
65STK30.99676328
66LRRK20.98749543
67BTK0.97300403
68WNK40.96459484
69SGK20.95877373
70FES0.93571980
71AKT30.91902905
72TXK0.91607664
73ERN10.90794086
74RIPK40.89653666
75TTN0.88790037
76MAP3K40.87716375
77LATS10.87643886
78MAP2K60.87500074
79CAMK1D0.85533032
80FGFR40.84956968
81CDK20.83914141
82MTOR0.83898980
83CSF1R0.83457007
84PIK3CA0.79335140
85RPS6KA50.79262791
86MELK0.78717702
87STK38L0.78585479
88CASK0.77154570
89STK390.76736201
90MAP2K30.76683735
91ZAP700.76137806
92PAK30.75571748
93CSK0.74745512
94WNK10.74347319
95IKBKB0.73907585
96MAPKAPK30.73533932
97CAMK1G0.72788255
98TESK20.70977416
99ITK0.70303455
100TRPM70.69546529
101MAP3K70.68905537
102TEC0.68477862
103PLK40.68234781
104TGFBR10.68039973
105FGFR30.67432269
106CHUK0.66845863
107PINK10.65933130
108MAPK110.65928572
109VRK10.65839371
110PRKAA20.65183435
111IRAK40.64881302
112PLK30.64462596
113PRKCQ0.64133507
114EIF2AK30.63800570
115KIT0.63319757
116TRIB30.62203940
117STK110.61901489
118MKNK10.61838456
119LCK0.61479089
120MARK30.60783334
121MAP3K140.59163129
122PAK40.57852568
123HCK0.57736971
124AURKA0.57046173
125TAOK30.56466443
126PTK60.55406536
127CAMK40.55137824
128CDK90.54933046
129CAMKK10.53289633
130BMX0.53145961
131EPHA30.52839301
132SIK20.52574236
133JAK10.51844455
134* CDK10.51659413
135MKNK20.49375510
136CSNK2A20.47935709
137FGFR20.47677633
138GRK70.46293165
139ERBB20.45379819
140LYN0.44629710
141CLK10.44312235
142SYK0.43975377
143JAK20.43182514
144SGK2230.42484311
145SGK4940.42484311
146CAMK10.41461956
147PRKCH0.41169704
148AKT20.41119266
149MST40.40745487
150BLK0.38798603
151PRKCE0.38565913
152SIK10.38223806
153PDK10.36948784
154BMPR20.35799703
155SGK10.35691877
156GRK50.34888063
157RPS6KA60.34839032
158STK380.34367662
159FGR0.33672420

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24427777
2Mismatch repair_Homo sapiens_hsa034303.75910091
3One carbon pool by folate_Homo sapiens_hsa006703.12362304
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78754618
5Base excision repair_Homo sapiens_hsa034102.71148354
6Homologous recombination_Homo sapiens_hsa034402.50471695
7Spliceosome_Homo sapiens_hsa030402.43621750
8RNA transport_Homo sapiens_hsa030132.40922046
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36655611
10Cell cycle_Homo sapiens_hsa041102.36017189
11Linoleic acid metabolism_Homo sapiens_hsa005912.31752364
12Nucleotide excision repair_Homo sapiens_hsa034202.20389921
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17679553
14Nitrogen metabolism_Homo sapiens_hsa009102.16529340
15Phototransduction_Homo sapiens_hsa047442.15038862
16Ribosome_Homo sapiens_hsa030102.10472795
17Fanconi anemia pathway_Homo sapiens_hsa034602.09156583
18Non-homologous end-joining_Homo sapiens_hsa034502.07681575
19Systemic lupus erythematosus_Homo sapiens_hsa053222.07144529
20ABC transporters_Homo sapiens_hsa020101.79859565
21Graft-versus-host disease_Homo sapiens_hsa053321.77769551
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77273822
23Primary immunodeficiency_Homo sapiens_hsa053401.75968636
24p53 signaling pathway_Homo sapiens_hsa041151.71256615
25Ether lipid metabolism_Homo sapiens_hsa005651.70853760
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69582660
27Dorso-ventral axis formation_Homo sapiens_hsa043201.55316115
28Butanoate metabolism_Homo sapiens_hsa006501.52977286
29mRNA surveillance pathway_Homo sapiens_hsa030151.49532041
30Allograft rejection_Homo sapiens_hsa053301.49332069
31RNA degradation_Homo sapiens_hsa030181.46191845
32Tryptophan metabolism_Homo sapiens_hsa003801.44461365
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44350084
34Autoimmune thyroid disease_Homo sapiens_hsa053201.43743010
35Pyrimidine metabolism_Homo sapiens_hsa002401.43239671
36Viral carcinogenesis_Homo sapiens_hsa052031.42303391
37Antigen processing and presentation_Homo sapiens_hsa046121.41704067
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41171367
39RNA polymerase_Homo sapiens_hsa030201.41026747
40Herpes simplex infection_Homo sapiens_hsa051681.34202769
41Selenocompound metabolism_Homo sapiens_hsa004501.31099093
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26739503
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.24214459
44Taste transduction_Homo sapiens_hsa047421.21985202
45Lysine degradation_Homo sapiens_hsa003101.20486256
46Morphine addiction_Homo sapiens_hsa050321.20146922
47Type I diabetes mellitus_Homo sapiens_hsa049401.18831672
48Nicotine addiction_Homo sapiens_hsa050331.18687305
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16901258
50Asthma_Homo sapiens_hsa053101.16766244
51Platelet activation_Homo sapiens_hsa046111.09256779
52Olfactory transduction_Homo sapiens_hsa047401.07127462
53Measles_Homo sapiens_hsa051621.05578624
54Glycerolipid metabolism_Homo sapiens_hsa005611.05369602
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03702747
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01796553
57Epstein-Barr virus infection_Homo sapiens_hsa051691.00651554
58MicroRNAs in cancer_Homo sapiens_hsa052060.99975424
59Serotonergic synapse_Homo sapiens_hsa047260.98719381
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.97598727
61B cell receptor signaling pathway_Homo sapiens_hsa046620.97538184
62Pentose phosphate pathway_Homo sapiens_hsa000300.96113345
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.93712962
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93421092
65Small cell lung cancer_Homo sapiens_hsa052220.92097649
66Basal transcription factors_Homo sapiens_hsa030220.91376755
67Calcium signaling pathway_Homo sapiens_hsa040200.89568383
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.89162083
69Apoptosis_Homo sapiens_hsa042100.88277386
70Ovarian steroidogenesis_Homo sapiens_hsa049130.87731979
71HTLV-I infection_Homo sapiens_hsa051660.87231678
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85681917
73Biosynthesis of amino acids_Homo sapiens_hsa012300.85645389
74Regulation of autophagy_Homo sapiens_hsa041400.85328961
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.84989064
76Arachidonic acid metabolism_Homo sapiens_hsa005900.82943638
77TNF signaling pathway_Homo sapiens_hsa046680.82626813
78Acute myeloid leukemia_Homo sapiens_hsa052210.79864448
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.79465539
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79146427
81Chronic myeloid leukemia_Homo sapiens_hsa052200.79006357
82Hematopoietic cell lineage_Homo sapiens_hsa046400.77785766
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77067691
84Notch signaling pathway_Homo sapiens_hsa043300.76193502
85Leishmaniasis_Homo sapiens_hsa051400.75413804
86Chemokine signaling pathway_Homo sapiens_hsa040620.73650073
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.72746547
88Hepatitis B_Homo sapiens_hsa051610.71851735
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71712803
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69831407
91Legionellosis_Homo sapiens_hsa051340.69377850
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69014398
93Type II diabetes mellitus_Homo sapiens_hsa049300.68889136
94Circadian entrainment_Homo sapiens_hsa047130.68293971
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67315560
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67073663
97Glutamatergic synapse_Homo sapiens_hsa047240.66667484
98Circadian rhythm_Homo sapiens_hsa047100.66213354
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65835606
100Cholinergic synapse_Homo sapiens_hsa047250.64516764
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63824674
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.63378791
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62999422
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62824472
105Salivary secretion_Homo sapiens_hsa049700.61573422
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.61397290
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61335728
108Staphylococcus aureus infection_Homo sapiens_hsa051500.60286699
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59884615
110T cell receptor signaling pathway_Homo sapiens_hsa046600.58549062
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.58519666
112Tuberculosis_Homo sapiens_hsa051520.58040424
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.57964474
114Influenza A_Homo sapiens_hsa051640.57802873
115Proteasome_Homo sapiens_hsa030500.57584475
116Folate biosynthesis_Homo sapiens_hsa007900.57224108
117Vitamin B6 metabolism_Homo sapiens_hsa007500.57054602
118Thyroid cancer_Homo sapiens_hsa052160.56642107
119Osteoclast differentiation_Homo sapiens_hsa043800.56376197
120mTOR signaling pathway_Homo sapiens_hsa041500.55925936
121Fatty acid biosynthesis_Homo sapiens_hsa000610.54455151
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54193241
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52909378
124Long-term depression_Homo sapiens_hsa047300.52883886
125Histidine metabolism_Homo sapiens_hsa003400.52785727
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52083827
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52063415
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51637987
129Oxytocin signaling pathway_Homo sapiens_hsa049210.49508281
130Purine metabolism_Homo sapiens_hsa002300.49338089
131Caffeine metabolism_Homo sapiens_hsa002320.48907017
132Inositol phosphate metabolism_Homo sapiens_hsa005620.48671157
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.48477341
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48207678
135Viral myocarditis_Homo sapiens_hsa054160.46948104
136Non-small cell lung cancer_Homo sapiens_hsa052230.46769244
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46619017
138GABAergic synapse_Homo sapiens_hsa047270.46137529
139Prolactin signaling pathway_Homo sapiens_hsa049170.45758806
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45653041
141Chemical carcinogenesis_Homo sapiens_hsa052040.45606503
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45296084
143Alcoholism_Homo sapiens_hsa050340.44654139
144Sulfur relay system_Homo sapiens_hsa041220.43768798
145Prostate cancer_Homo sapiens_hsa052150.43695844
146Carbon metabolism_Homo sapiens_hsa012000.42985676
147MAPK signaling pathway_Homo sapiens_hsa040100.42788572
148Adherens junction_Homo sapiens_hsa045200.42497569
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42471471
150Pancreatic cancer_Homo sapiens_hsa052120.42059117
151Toxoplasmosis_Homo sapiens_hsa051450.41265090
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.40950961
153Bladder cancer_Homo sapiens_hsa052190.38836192
154HIF-1 signaling pathway_Homo sapiens_hsa040660.38306144
155Colorectal cancer_Homo sapiens_hsa052100.37260652
156Other glycan degradation_Homo sapiens_hsa005110.37098028
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36604320
158Shigellosis_Homo sapiens_hsa051310.36238433
159FoxO signaling pathway_Homo sapiens_hsa040680.33876524
160Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33680631
161Fructose and mannose metabolism_Homo sapiens_hsa000510.33229577
162Galactose metabolism_Homo sapiens_hsa000520.33136795
163Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33042920
1642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32211451
165Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31375071

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