HELQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.68177628
2mitotic chromosome condensation (GO:0007076)5.12351428
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.93092823
4metaphase plate congression (GO:0051310)4.90278943
5DNA replication checkpoint (GO:0000076)4.79222247
6folic acid-containing compound biosynthetic process (GO:0009396)4.64400247
7mitotic sister chromatid segregation (GO:0000070)4.63273804
8protein localization to kinetochore (GO:0034501)4.59435486
9mitotic nuclear envelope disassembly (GO:0007077)4.46549900
10DNA replication initiation (GO:0006270)4.45967092
11establishment of chromosome localization (GO:0051303)4.38949904
12chromatin remodeling at centromere (GO:0031055)4.23993758
13protein K6-linked ubiquitination (GO:0085020)4.23336010
14nuclear envelope disassembly (GO:0051081)4.22144065
15membrane disassembly (GO:0030397)4.22144065
16regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.19753415
17CENP-A containing nucleosome assembly (GO:0034080)4.19390294
18regulation of spindle organization (GO:0090224)4.17524953
19DNA replication-independent nucleosome assembly (GO:0006336)4.15177128
20DNA replication-independent nucleosome organization (GO:0034724)4.15177128
21protein localization to chromosome, centromeric region (GO:0071459)4.14892345
22sister chromatid segregation (GO:0000819)4.13852161
23meiotic chromosome segregation (GO:0045132)4.13542467
24attachment of spindle microtubules to kinetochore (GO:0008608)4.13488714
25monoubiquitinated protein deubiquitination (GO:0035520)4.04124118
26DNA replication-dependent nucleosome assembly (GO:0006335)4.00722632
27DNA replication-dependent nucleosome organization (GO:0034723)4.00722632
28histone H2A monoubiquitination (GO:0035518)3.97204617
29regulation of histone H3-K27 methylation (GO:0061085)3.96017298
30regulation of sister chromatid cohesion (GO:0007063)3.88666417
31maturation of 5.8S rRNA (GO:0000460)3.88108572
32DNA strand elongation involved in DNA replication (GO:0006271)3.83656128
33rRNA modification (GO:0000154)3.83468506
34positive regulation of chromosome segregation (GO:0051984)3.81702201
35histone exchange (GO:0043486)3.81522688
36regulation of meiosis I (GO:0060631)3.79014583
37rRNA methylation (GO:0031167)3.78588872
38mitotic sister chromatid cohesion (GO:0007064)3.77218062
39nuclear pore organization (GO:0006999)3.69520463
40negative regulation of histone methylation (GO:0031061)3.69517497
41DNA strand elongation (GO:0022616)3.69457082
42regulation of centrosome cycle (GO:0046605)3.69456605
43regulation of chromosome segregation (GO:0051983)3.69302562
44positive regulation of DNA-dependent DNA replication (GO:2000105)3.67583801
45chromatin assembly or disassembly (GO:0006333)3.67229504
46chromosome segregation (GO:0007059)3.67221332
47kinetochore organization (GO:0051383)3.66392846
48nuclear pore complex assembly (GO:0051292)3.65705822
49protein localization to chromosome (GO:0034502)3.65129921
50regulation of mitotic spindle organization (GO:0060236)3.65086020
51regulation of exit from mitosis (GO:0007096)3.64018081
52negative regulation of meiosis (GO:0045835)3.61915947
53spindle checkpoint (GO:0031577)3.61357639
54mismatch repair (GO:0006298)3.61059051
55piRNA metabolic process (GO:0034587)3.57894895
56positive regulation of granulocyte differentiation (GO:0030854)3.54548318
57regulation of centriole replication (GO:0046599)3.52602247
58oocyte maturation (GO:0001556)3.52301544
59DNA damage response, signal transduction resulting in transcription (GO:0042772)3.51956605
60negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.50716351
61DNA unwinding involved in DNA replication (GO:0006268)3.50113325
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49689459
63kinetochore assembly (GO:0051382)3.49422933
64negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.49127321
65negative regulation of DNA-templated transcription, elongation (GO:0032785)3.49127321
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47436981
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.47436981
68regulation of meiosis (GO:0040020)3.47247904
69telomere maintenance via semi-conservative replication (GO:0032201)3.45671400
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45351075
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.41456555
72respiratory chain complex IV assembly (GO:0008535)3.41362490
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40487789
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39397391
75histone mRNA metabolic process (GO:0008334)3.39310407
76telomere maintenance via recombination (GO:0000722)3.38556162
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37240849
78nucleobase biosynthetic process (GO:0046112)3.36782668
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36405119
80nuclear envelope organization (GO:0006998)3.35832550
81mitotic spindle checkpoint (GO:0071174)3.35033202
82negative regulation of chromosome segregation (GO:0051985)3.34550483
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31955471
84DNA double-strand break processing (GO:0000729)3.31224286
85purine nucleobase biosynthetic process (GO:0009113)3.30786589
86positive regulation of histone H3-K4 methylation (GO:0051571)3.30603024
87histone H2A ubiquitination (GO:0033522)3.30373170
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.30185688
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30185688
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30185688
91negative regulation of sister chromatid segregation (GO:0033046)3.30185688
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28403910
93proteasome assembly (GO:0043248)3.28204927
94histone mRNA catabolic process (GO:0071044)3.27848039
95regulation of B cell receptor signaling pathway (GO:0050855)3.27825701
96male meiosis (GO:0007140)3.27347313
97mitotic recombination (GO:0006312)3.26129574
98meiotic cell cycle (GO:0051321)3.24763612
99centriole replication (GO:0007099)3.22869665
100sister chromatid cohesion (GO:0007062)3.22806504
101mitotic spindle assembly checkpoint (GO:0007094)3.21257071
102regulation of telomere maintenance via telomerase (GO:0032210)3.20973001
103spindle assembly checkpoint (GO:0071173)3.20470136
104inner cell mass cell proliferation (GO:0001833)3.19707066
105regulation of mitotic spindle checkpoint (GO:1903504)3.15791765
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15791765
107rRNA catabolic process (GO:0016075)3.15728393
108regulation of mitotic sister chromatid separation (GO:0010965)3.14543690
109regulation of mitotic sister chromatid segregation (GO:0033047)3.14543690
110regulation of sister chromatid segregation (GO:0033045)3.14543690
111organelle disassembly (GO:1903008)3.14181177
112female gamete generation (GO:0007292)3.14142088
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12884770
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12884770
115positive regulation of mitotic sister chromatid separation (GO:1901970)3.12884770
116protein targeting to Golgi (GO:0000042)3.10850382
117establishment of protein localization to Golgi (GO:0072600)3.10796982
118mitochondrial RNA metabolic process (GO:0000959)3.10146133
119nucleotide-excision repair, DNA gap filling (GO:0006297)3.09358873
120regulation of DNA endoreduplication (GO:0032875)3.03554654
121cytochrome complex assembly (GO:0017004)3.00439696
122positive regulation of B cell differentiation (GO:0045579)2.88196183
123protein deneddylation (GO:0000338)2.85981849
124cullin deneddylation (GO:0010388)2.85167215
125positive regulation of vasculogenesis (GO:2001214)2.84372301
126purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.80963124
127retrograde transport, vesicle recycling within Golgi (GO:0000301)2.76731440
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76240669
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76240669
130signal peptide processing (GO:0006465)2.75972937
131regulation of MHC class II biosynthetic process (GO:0045346)2.74963355
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.70529424
133positive regulation of gamma-delta T cell activation (GO:0046645)2.66162689
134purine-containing compound salvage (GO:0043101)2.65007144
135replication fork processing (GO:0031297)2.62235172
136peptidyl-lysine trimethylation (GO:0018023)2.62008695
137histone H2A acetylation (GO:0043968)2.60793102
138deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60125798
139prenylation (GO:0097354)2.58502731
140protein prenylation (GO:0018342)2.58502731
141ribonucleoprotein complex disassembly (GO:0032988)2.58103647
142regulation of fibroblast apoptotic process (GO:2000269)2.57693837
143viral mRNA export from host cell nucleus (GO:0046784)2.52880959
144protein complex biogenesis (GO:0070271)2.52575286
145DNA demethylation (GO:0080111)2.49974296
146adenosine metabolic process (GO:0046085)2.48142390
147neural tube formation (GO:0001841)2.47603698
148histone H3-K4 trimethylation (GO:0080182)2.47205106
149hepatocyte apoptotic process (GO:0097284)2.46973532
150cell wall macromolecule catabolic process (GO:0016998)2.43605633
151positive regulation of histone methylation (GO:0031062)2.43180490
152mitotic G2 DNA damage checkpoint (GO:0007095)2.42695001
153regulation of glucokinase activity (GO:0033131)2.42441666
154regulation of hexokinase activity (GO:1903299)2.42441666
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.42228379
156positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40151655
157mitochondrial respiratory chain complex assembly (GO:0033108)2.39021775
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.37968379
159protein localization to Golgi apparatus (GO:0034067)2.37568339
160ncRNA catabolic process (GO:0034661)2.35598724
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.35288670
162protein K11-linked deubiquitination (GO:0035871)2.34880707
163synapsis (GO:0007129)2.34454162
164mitotic G2/M transition checkpoint (GO:0044818)2.34326816
165regulation of B cell differentiation (GO:0045577)2.34203977
166definitive hemopoiesis (GO:0060216)2.33911003
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.33522131
168NADH dehydrogenase complex assembly (GO:0010257)2.33522131
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33522131
170regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.28248423
171regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.28230468
172protein K11-linked ubiquitination (GO:0070979)2.27906368
173snRNA processing (GO:0016180)2.26759744
174Rap protein signal transduction (GO:0032486)2.26257893
175cellular response to glucose starvation (GO:0042149)2.24777499
176regulation of interleukin-1 beta secretion (GO:0050706)2.24123665
177epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.23829140
178positive regulation of interleukin-1 beta secretion (GO:0050718)2.23603023
179regulation of acyl-CoA biosynthetic process (GO:0050812)2.23553492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.90282612
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37004508
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.05995873
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24119649
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.20608861
6AR_21909140_ChIP-Seq_LNCAP_Human3.02788196
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.74525048
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67689351
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58996806
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52429895
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41139817
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.32680394
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.32405826
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28362563
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28003071
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26755966
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.25037535
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18471586
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14117142
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13916356
21MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12086691
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.05855989
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04011834
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02101393
25E2F7_22180533_ChIP-Seq_HELA_Human11.2995223
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98146257
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.95810469
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94120760
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91991209
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90668522
31ZNF274_21170338_ChIP-Seq_K562_Hela1.89287039
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88557228
33MYC_22102868_ChIP-Seq_BL_Human1.86672025
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.84224058
35FUS_26573619_Chip-Seq_HEK293_Human1.84166349
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.83332612
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.82875530
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82595714
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78848060
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76954712
41GABP_19822575_ChIP-Seq_HepG2_Human1.74820032
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74384829
43EWS_26573619_Chip-Seq_HEK293_Human1.73287426
44XRN2_22483619_ChIP-Seq_HELA_Human1.73274643
45VDR_23849224_ChIP-Seq_CD4+_Human1.71088034
46KDM5A_27292631_Chip-Seq_BREAST_Human1.70120657
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.69569430
48CIITA_25753668_ChIP-Seq_RAJI_Human1.67694101
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64245043
50DCP1A_22483619_ChIP-Seq_HELA_Human1.58195921
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56644555
52* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55072908
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54822942
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50665068
55VDR_22108803_ChIP-Seq_LS180_Human1.48509840
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47154596
57TAF15_26573619_Chip-Seq_HEK293_Human1.46962777
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45504409
59IRF1_19129219_ChIP-ChIP_H3396_Human1.45256331
60IGF1R_20145208_ChIP-Seq_DFB_Human1.44101188
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.43662436
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42290382
63* FOXP3_21729870_ChIP-Seq_TREG_Human1.41412870
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40730155
65TTF2_22483619_ChIP-Seq_HELA_Human1.39071675
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39049242
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38099997
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37517711
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37059448
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36572924
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35560640
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34137096
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33076231
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31959489
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31165054
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30917250
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30730489
78SPI1_23547873_ChIP-Seq_NB4_Human1.28136203
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27180630
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27096172
81* MYB_26560356_Chip-Seq_TH2_Human1.26667386
82GATA3_26560356_Chip-Seq_TH2_Human1.25236822
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.21664000
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20787262
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19516249
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.18004783
87MYC_18940864_ChIP-ChIP_HL60_Human1.17930851
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17025246
89ER_23166858_ChIP-Seq_MCF-7_Human1.16663222
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.16421105
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.16025553
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15991052
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15628551
94SCL_19346495_ChIP-Seq_HPC-7_Human1.15230602
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14481184
96* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14381269
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14283319
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12849739
99P300_19829295_ChIP-Seq_ESCs_Human1.11231490
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11187916
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10144724
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09781681
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09472261
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08455215
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.08356538
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07823281
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07201240
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05998348
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05140680
110CBP_20019798_ChIP-Seq_JUKART_Human1.03457446
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03457446
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03165707
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03119715
114TP53_22573176_ChIP-Seq_HFKS_Human1.01693924
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00825436
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00299997
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.99856546
118* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99337943
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99189151
120* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99125443
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99059614
122GATA3_27048872_Chip-Seq_THYMUS_Human0.98952390
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98935869
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98495636
125SOX2_19829295_ChIP-Seq_ESCs_Human0.98350218
126NANOG_19829295_ChIP-Seq_ESCs_Human0.98350218
127TFEB_21752829_ChIP-Seq_HELA_Human0.98238708
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97078280
129MYB_26560356_Chip-Seq_TH1_Human0.96814245
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96158985
131IRF8_27001747_Chip-Seq_BMDM_Mouse0.95624818
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94543658
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94484439
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94470769
135RUNX_20019798_ChIP-Seq_JUKART_Human0.94452308
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94343779
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94086845
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94068911
139ELK1_19687146_ChIP-ChIP_HELA_Human0.93640978
140HTT_18923047_ChIP-ChIP_STHdh_Human0.93425501
141* CDX2_22108803_ChIP-Seq_LS180_Human0.93258096
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93124135
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92880843
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.84085590
145TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83866962
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.81380653
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78850879
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.77021637
149CHD1_26751641_Chip-Seq_LNCaP_Human0.76549359
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76491678
151NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75693852
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74587724
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74567684
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.73144968
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.72831752
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.72581929
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71707122
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71630505
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70946262
160TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69998031
161TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69961446
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.68905939
163TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67072507
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66871915
165TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.65983610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.93032569
2MP0010094_abnormal_chromosome_stability4.96167399
3MP0003111_abnormal_nucleus_morphology4.79822429
4MP0004957_abnormal_blastocyst_morpholog4.07801512
5MP0003077_abnormal_cell_cycle3.98073037
6MP0008877_abnormal_DNA_methylation3.74036449
7MP0008057_abnormal_DNA_replication3.14791250
8MP0003718_maternal_effect3.14268838
9MP0003123_paternal_imprinting3.13908307
10MP0003806_abnormal_nucleotide_metabolis2.88221683
11MP0002102_abnormal_ear_morphology2.77514539
12MP0008058_abnormal_DNA_repair2.76683584
13MP0001835_abnormal_antigen_presentation2.72435555
14MP0008007_abnormal_cellular_replicative2.63220794
15MP0003121_genomic_imprinting2.50192208
16MP0002653_abnormal_ependyma_morphology2.49947425
17MP0006292_abnormal_olfactory_placode2.36702365
18MP0008932_abnormal_embryonic_tissue2.36191220
19MP0001730_embryonic_growth_arrest2.31009395
20MP0002837_dystrophic_cardiac_calcinosis2.28281949
21MP0000350_abnormal_cell_proliferation2.25499792
22MP0005451_abnormal_body_composition2.24209901
23MP0003195_calcinosis2.21959832
24MP0006054_spinal_hemorrhage2.12369317
25MP0003787_abnormal_imprinting2.10673100
26MP0003724_increased_susceptibility_to2.05615223
27MP0010307_abnormal_tumor_latency2.03261121
28MP0001800_abnormal_humoral_immune1.96170999
29MP0006036_abnormal_mitochondrial_physio1.94791050
30MP0001697_abnormal_embryo_size1.85286998
31MP0005075_abnormal_melanosome_morpholog1.79883097
32MP0004215_abnormal_myocardial_fiber1.78752669
33MP0001672_abnormal_embryogenesis/_devel1.77475430
34MP0005380_embryogenesis_phenotype1.77475430
35MP0002085_abnormal_embryonic_tissue1.74438017
36MP0003646_muscle_fatigue1.73824403
37MP0005084_abnormal_gallbladder_morpholo1.72761607
38MP0002210_abnormal_sex_determination1.71962211
39MP0001929_abnormal_gametogenesis1.70796553
40MP0005464_abnormal_platelet_physiology1.66906368
41MP0002084_abnormal_developmental_patter1.66757252
42MP0005671_abnormal_response_to1.66053904
43MP0001119_abnormal_female_reproductive1.65719076
44MP0000372_irregular_coat_pigmentation1.65155899
45MP0000569_abnormal_digit_pigmentation1.63257895
46MP0009785_altered_susceptibility_to1.63023733
47MP0001764_abnormal_homeostasis1.62391664
48MP0006035_abnormal_mitochondrial_morpho1.61835749
49MP0004264_abnormal_extraembryonic_tissu1.59648689
50MP0005000_abnormal_immune_tolerance1.58028017
51MP0000653_abnormal_sex_gland1.57757938
52MP0003699_abnormal_female_reproductive1.54184326
53MP0009697_abnormal_copulation1.53923579
54MP0003186_abnormal_redox_activity1.53491560
55MP0002452_abnormal_antigen_presenting1.52681903
56MP0003984_embryonic_growth_retardation1.51892698
57MP0004147_increased_porphyrin_level1.50711184
58MP0003786_premature_aging1.48756876
59MP0005076_abnormal_cell_differentiation1.48166538
60MP0010352_gastrointestinal_tract_polyps1.48099454
61MP0002088_abnormal_embryonic_growth/wei1.47115112
62MP0003890_abnormal_embryonic-extraembry1.46432935
63MP0002723_abnormal_immune_serum1.46107198
64MP0005174_abnormal_tail_pigmentation1.45262586
65MP0002080_prenatal_lethality1.45177083
66MP0000465_gastrointestinal_hemorrhage1.44287618
67MP0000015_abnormal_ear_pigmentation1.43226587
68MP0002148_abnormal_hypersensitivity_rea1.42711448
69MP0002405_respiratory_system_inflammati1.42182185
70MP0002396_abnormal_hematopoietic_system1.41731831
71MP0001145_abnormal_male_reproductive1.40606889
72MP0004084_abnormal_cardiac_muscle1.40606498
73MP0002420_abnormal_adaptive_immunity1.37414507
74MP0000490_abnormal_crypts_of1.36819237
75MP0009764_decreased_sensitivity_to1.36270601
76MP0005395_other_phenotype1.35272714
77MP0001819_abnormal_immune_cell1.35063515
78MP0002086_abnormal_extraembryonic_tissu1.33881470
79MP0002019_abnormal_tumor_incidence1.29402293
80MP0001790_abnormal_immune_system1.27224736
81MP0005387_immune_system_phenotype1.27224736
82MP0002877_abnormal_melanocyte_morpholog1.25726740
83MP0000313_abnormal_cell_death1.24956622
84MP0003937_abnormal_limbs/digits/tail_de1.20338572
85MP0002419_abnormal_innate_immunity1.19187879
86MP0005253_abnormal_eye_physiology1.18357417
87MP0005266_abnormal_metabolism1.17312524
88MP0000716_abnormal_immune_system1.14763433
89MP0004808_abnormal_hematopoietic_stem1.14416799
90MP0002166_altered_tumor_susceptibility1.06744334
91MP0004036_abnormal_muscle_relaxation1.04212617
92MP0005408_hypopigmentation1.02769734
93MP0005621_abnormal_cell_physiology1.02655245
94MP0000685_abnormal_immune_system1.00213731
95MP0002161_abnormal_fertility/fecundity1.00129142
96MP0000703_abnormal_thymus_morphology0.97902207
97MP0000462_abnormal_digestive_system0.97252468
98MP0005025_abnormal_response_to0.95816528
99MP0004233_abnormal_muscle_weight0.95697191
100MP0001845_abnormal_inflammatory_respons0.95103984
101MP0005384_cellular_phenotype0.95027545
102MP0004185_abnormal_adipocyte_glucose0.94847284
103MP0005389_reproductive_system_phenotype0.94174378
104MP0009672_abnormal_birth_weight0.93196626
105MP0005310_abnormal_salivary_gland0.92659735
106MP0002332_abnormal_exercise_endurance0.91132625
107MP0002006_tumorigenesis0.90826171
108MP0003119_abnormal_digestive_system0.90770475
109MP0003763_abnormal_thymus_physiology0.90591875
110MP0002160_abnormal_reproductive_system0.88589408
111MP0002928_abnormal_bile_duct0.88401808
112MP0003315_abnormal_perineum_morphology0.86046884
113MP0003183_abnormal_peptide_metabolism0.85357242
114MP0008469_abnormal_protein_level0.85067622
115MP0004197_abnormal_fetal_growth/weight/0.84429025
116MP0002127_abnormal_cardiovascular_syste0.83957800
117MP0001915_intracranial_hemorrhage0.83743170
118MP0005376_homeostasis/metabolism_phenot0.83639889
119MP0003011_delayed_dark_adaptation0.82100995
120MP0003698_abnormal_male_reproductive0.80784590
121MP0001529_abnormal_vocalization0.80737141
122MP0002398_abnormal_bone_marrow0.80281250
123MP0002163_abnormal_gland_morphology0.79884440
124MP0006072_abnormal_retinal_apoptosis0.79780366
125MP0001919_abnormal_reproductive_system0.79732357
126MP0010155_abnormal_intestine_physiology0.78245938
127MP0002095_abnormal_skin_pigmentation0.77919198
128MP0002249_abnormal_larynx_morphology0.76788420
129MP0002277_abnormal_respiratory_mucosa0.76613297
130MP0008961_abnormal_basal_metabolism0.76304122
131MP0005379_endocrine/exocrine_gland_phen0.74795670
132MP0002009_preneoplasia0.74216009
133MP0001986_abnormal_taste_sensitivity0.72135622
134MP0003861_abnormal_nervous_system0.71780598
135MP0005551_abnormal_eye_electrophysiolog0.71139199
136MP0000516_abnormal_urinary_system0.68984384
137MP0005367_renal/urinary_system_phenotyp0.68984384
138MP0000689_abnormal_spleen_morphology0.68712083
139MP0005332_abnormal_amino_acid0.68287835
140MP0003950_abnormal_plasma_membrane0.67997281
141MP0010030_abnormal_orbit_morphology0.67747418
142MP0010234_abnormal_vibrissa_follicle0.67663661
143MP0001849_ear_inflammation0.66173498
144MP0002722_abnormal_immune_system0.64097255
145MP0000678_abnormal_parathyroid_gland0.63624396
146MP0003656_abnormal_erythrocyte_physiolo0.61330332
147MP0009703_decreased_birth_body0.61116013
148MP0003755_abnormal_palate_morphology0.60047014
149MP0009333_abnormal_splenocyte_physiolog0.59956376
150MP0000428_abnormal_craniofacial_morphol0.59196911
151MP0001293_anophthalmia0.58474258
152MP0005397_hematopoietic_system_phenotyp0.57833557
153MP0001545_abnormal_hematopoietic_system0.57833557
154MP0001286_abnormal_eye_development0.55754587
155MP0000432_abnormal_head_morphology0.55513522
156MP0008995_early_reproductive_senescence0.55392416
157MP0000358_abnormal_cell_content/0.55025412
158MP0003935_abnormal_craniofacial_develop0.54090383
159MP0005646_abnormal_pituitary_gland0.51990485
160MP0002429_abnormal_blood_cell0.47529957
161MP0008260_abnormal_autophagy0.47431903
162MP0002111_abnormal_tail_morphology0.46725709
163MP0000579_abnormal_nail_morphology0.45590156
164MP0002116_abnormal_craniofacial_bone0.45471592
165MP0003221_abnormal_cardiomyocyte_apopto0.44852861

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.35445872
2Chromsome breakage (HP:0040012)4.61447099
3Abnormality of the labia minora (HP:0012880)4.52848522
4Breast hypoplasia (HP:0003187)4.52645300
5Patellar aplasia (HP:0006443)4.33019442
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30631348
7Aplasia/Hypoplasia of the patella (HP:0006498)3.98309177
8Facial hemangioma (HP:0000329)3.66042922
9Abnormality of chromosome stability (HP:0003220)3.64062913
10Abnormality of the fingertips (HP:0001211)3.41680399
11Male infertility (HP:0003251)3.35818052
12Papillary thyroid carcinoma (HP:0002895)3.30517606
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.24423720
14Abnormality of the preputium (HP:0100587)3.14944079
15Shawl scrotum (HP:0000049)3.14006578
16Medulloblastoma (HP:0002885)3.04332382
17Impulsivity (HP:0100710)2.98773657
18Meckel diverticulum (HP:0002245)2.98112608
19Absent radius (HP:0003974)2.91978915
20Methylmalonic acidemia (HP:0002912)2.89977891
21Abnormality of the ileum (HP:0001549)2.85111485
22Rhabdomyosarcoma (HP:0002859)2.83805368
23Volvulus (HP:0002580)2.80421582
24Aplasia involving forearm bones (HP:0009822)2.80135300
25Absent forearm bone (HP:0003953)2.80135300
26Ependymoma (HP:0002888)2.79274672
27Oligodactyly (hands) (HP:0001180)2.78040084
28Stomatitis (HP:0010280)2.76281372
29Small intestinal stenosis (HP:0012848)2.70451788
30Duodenal stenosis (HP:0100867)2.70451788
31Myelodysplasia (HP:0002863)2.68785017
32Oligodactyly (HP:0012165)2.68418391
33Breast aplasia (HP:0100783)2.67370815
34Increased CSF lactate (HP:0002490)2.66021380
35Cafe-au-lait spot (HP:0000957)2.64170749
36Progressive macrocephaly (HP:0004481)2.62207996
37Increased hepatocellular lipid droplets (HP:0006565)2.61838310
38Carpal bone hypoplasia (HP:0001498)2.61649360
39Acute necrotizing encephalopathy (HP:0006965)2.61019488
40Secondary amenorrhea (HP:0000869)2.56337124
41Capillary hemangiomas (HP:0005306)2.54391031
42Hepatocellular necrosis (HP:0001404)2.53229419
43Aplasia/Hypoplasia of the breasts (HP:0010311)2.52442665
44Sandal gap (HP:0001852)2.52401220
45Hepatic necrosis (HP:0002605)2.51816046
46Lipid accumulation in hepatocytes (HP:0006561)2.51462624
47Renal cortical cysts (HP:0000803)2.50573088
48Abnormality of the anterior horn cell (HP:0006802)2.49484298
49Degeneration of anterior horn cells (HP:0002398)2.49484298
50Agnosia (HP:0010524)2.49399111
51Mitochondrial inheritance (HP:0001427)2.47433879
52Ectopic kidney (HP:0000086)2.46831177
53Premature ovarian failure (HP:0008209)2.45807347
54Acute encephalopathy (HP:0006846)2.45533731
55Methylmalonic aciduria (HP:0012120)2.44370075
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.44112537
57Abnormality of lateral ventricle (HP:0030047)2.43670256
583-Methylglutaconic aciduria (HP:0003535)2.40424535
59Sloping forehead (HP:0000340)2.39821798
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37584711
61Panhypogammaglobulinemia (HP:0003139)2.36604417
62Abnormality of chromosome segregation (HP:0002916)2.36380014
63Prominent nose (HP:0000448)2.35233423
64Abnormality of B cell number (HP:0010975)2.33087952
65Overlapping toe (HP:0001845)2.32953467
66Supernumerary spleens (HP:0009799)2.32712955
67Pancreatic cysts (HP:0001737)2.31737818
68Acute myeloid leukemia (HP:0004808)2.30968943
69Abnormality of the duodenum (HP:0002246)2.30089639
70Abnormal biliary tract physiology (HP:0012439)2.29352669
71Bile duct proliferation (HP:0001408)2.29352669
72Abnormality of the prostate (HP:0008775)2.28816805
73Microvesicular hepatic steatosis (HP:0001414)2.26958204
74Metaphyseal dysplasia (HP:0100255)2.25506528
75Biliary tract neoplasm (HP:0100574)2.25110802
76Abnormality of methionine metabolism (HP:0010901)2.24972830
77Oral leukoplakia (HP:0002745)2.24157135
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23087147
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23087147
80Abnormality of the renal cortex (HP:0011035)2.23069199
81Abnormality of the carotid arteries (HP:0005344)2.21127312
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20982370
83Hypothermia (HP:0002045)2.20788063
84Increased serum lactate (HP:0002151)2.20086995
85Astrocytoma (HP:0009592)2.19364172
86Abnormality of the astrocytes (HP:0100707)2.19364172
87Intestinal atresia (HP:0011100)2.18720357
88Pancreatic fibrosis (HP:0100732)2.17593453
89Abnormal mitochondria in muscle tissue (HP:0008316)2.16321761
90Horseshoe kidney (HP:0000085)2.15933799
91Flat capital femoral epiphysis (HP:0003370)2.13658925
92Severe combined immunodeficiency (HP:0004430)2.10159276
93Slender long bone (HP:0003100)2.09836180
94Thyroiditis (HP:0100646)2.09824712
95Lactic acidosis (HP:0003128)2.08924525
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08659443
97High pitched voice (HP:0001620)2.08045416
98Neoplasm of striated muscle (HP:0009728)2.07725108
99Abnormality of vitamin B metabolism (HP:0004340)2.07536615
100Muscle fiber atrophy (HP:0100295)2.06080354
101Short thumb (HP:0009778)2.05838083
102Neoplasm of the oral cavity (HP:0100649)2.05074299
103Stomach cancer (HP:0012126)2.05064594
104Sparse lateral eyebrow (HP:0005338)2.04361659
105Hypoproteinemia (HP:0003075)2.04326541
106Prolonged bleeding time (HP:0003010)2.03232608
107Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02239742
108Selective tooth agenesis (HP:0001592)2.00501422
109Bone marrow hypocellularity (HP:0005528)1.99615654
110Type I transferrin isoform profile (HP:0003642)1.99581904
111Exertional dyspnea (HP:0002875)1.98635261
112Acute hepatic failure (HP:0006554)1.98419786
113Basal cell carcinoma (HP:0002671)1.97500077
114IgM deficiency (HP:0002850)1.96944193
115Long eyelashes (HP:0000527)1.95929033
116Abnormality of the labia (HP:0000058)1.95341503
117Adrenal hypoplasia (HP:0000835)1.95055701
118Glioma (HP:0009733)1.94990545
119Insulin-resistant diabetes mellitus (HP:0000831)1.93157064
120Rough bone trabeculation (HP:0100670)1.92867195
121Optic neuritis (HP:0100653)1.91192506
122Retrobulbar optic neuritis (HP:0100654)1.91192506
123Anal stenosis (HP:0002025)1.91150267
124Deep palmar crease (HP:0006191)1.91087418
125Type 2 muscle fiber atrophy (HP:0003554)1.90855451
126Clubbing of toes (HP:0100760)1.90258716
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89923771
128Abnormality of T cell number (HP:0011839)1.89418225
129B lymphocytopenia (HP:0010976)1.89376149
130Neoplasm of the pancreas (HP:0002894)1.88847199
131Hyperglycemia (HP:0003074)1.87908670
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.87751055
133Hypoplasia of the pons (HP:0012110)1.86520186
134Medial flaring of the eyebrow (HP:0010747)1.86453583
135Abnormal biliary tract morphology (HP:0012440)1.85552563
136Delayed puberty (HP:0000823)1.85372515
137Pulmonary fibrosis (HP:0002206)1.83649130
138Dyskinesia (HP:0100660)1.82764485
139Autoimmune hemolytic anemia (HP:0001890)1.82259707
140Gastrointestinal carcinoma (HP:0002672)1.82072797
141Malignant gastrointestinal tract tumors (HP:0006749)1.82072797
142Absent thumb (HP:0009777)1.81881358
143Chronic hepatic failure (HP:0100626)1.81842032
144Respiratory difficulties (HP:0002880)1.81648878
145Microtia (HP:0008551)1.81395333
146Abnormality of serum amino acid levels (HP:0003112)1.81278996
147Abnormal number of incisors (HP:0011064)1.81124676
148Neutropenia (HP:0001875)1.80977841
149Renal Fanconi syndrome (HP:0001994)1.80649655
150Recurrent fungal infections (HP:0002841)1.80642835
151Increased nuchal translucency (HP:0010880)1.80405041
152Abnormality of T cells (HP:0002843)1.79702383
153Lip pit (HP:0100267)1.79617331
154Generalized aminoaciduria (HP:0002909)1.79373955
155Abnormality of cochlea (HP:0000375)1.79368013
156Abnormality of T cell physiology (HP:0011840)1.79339505
157Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79042001
158Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78887813
159Colon cancer (HP:0003003)1.78326688
160Short tibia (HP:0005736)1.78088473
161Abnormality of small intestinal villus morphology (HP:0011472)1.77921013
162Villous atrophy (HP:0011473)1.77921013
163Combined immunodeficiency (HP:0005387)1.77905643
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.77389953
165Hypoplasia of the fovea (HP:0007750)1.77389953
166Attenuation of retinal blood vessels (HP:0007843)1.76784947
167Abnormality of the pons (HP:0007361)1.76431394
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76430772
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76182100
170Abnormal protein N-linked glycosylation (HP:0012347)1.76182100
171Abnormal protein glycosylation (HP:0012346)1.76182100
172Abnormal glycosylation (HP:0012345)1.76182100
173Abnormal delayed hypersensitivity skin test (HP:0002963)1.75171978
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74670669
175Abnormality of alanine metabolism (HP:0010916)1.74670669
176Hyperalaninemia (HP:0003348)1.74670669
177T lymphocytopenia (HP:0005403)1.74064427
178IgG deficiency (HP:0004315)1.74024790
179Aplasia/Hypoplasia of the tibia (HP:0005772)1.73994311
180Facial diplegia (HP:0001349)1.73804690
181Conjunctival telangiectasia (HP:0000524)1.72891981
182Nephronophthisis (HP:0000090)1.72813590
183Dyschromatopsia (HP:0007641)1.72389033
184Petechiae (HP:0000967)1.71140888
185Recurrent viral infections (HP:0004429)1.70762775
186Choroideremia (HP:0001139)1.70275156
187True hermaphroditism (HP:0010459)1.69653581
188Abnormality of the basal ganglia (HP:0002134)1.69591539
189Cerebral edema (HP:0002181)1.69438140
190Neoplasm of the tracheobronchial system (HP:0100552)1.68741908
191Absent/shortened dynein arms (HP:0200106)1.66840633
192Dynein arm defect of respiratory motile cilia (HP:0012255)1.66840633
193Aplastic anemia (HP:0001915)1.66071393
194Abnormal rod and cone electroretinograms (HP:0008323)1.65833594
195Disinhibition (HP:0000734)1.65178654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.68007380
2MAP4K23.81160758
3PLK43.52077867
4TTK3.26930785
5EEF2K3.03531844
6NEK22.96904168
7FRK2.77749795
8LATS12.71081250
9BUB12.68387201
10WEE12.65768718
11BRAF2.52158146
12ACVR1B2.48830847
13KSR22.30828631
14MAP3K92.27610916
15TEC2.22846308
16RAF12.06343909
17MST42.05772873
18CDK122.04721639
19CAMKK22.04716348
20MAP3K62.02472844
21LATS21.97522501
22PLK11.97087989
23STK38L1.90154878
24TAOK11.89547242
25ERBB41.88206996
26CHEK21.87721004
27TNIK1.86241690
28TAOK31.83213913
29PBK1.81263743
30BLK1.71118519
31SRPK11.68967724
32KSR11.67506014
33CDK81.65232191
34MELK1.63850730
35PLK31.62172921
36BMPR21.60339960
37MAP3K131.56278431
38ATR1.50249374
39OBSCN1.49720667
40ARAF1.47690493
41BRSK21.47266442
42TXK1.45674534
43BRSK11.44515857
44TRIM281.42780640
45PIK3CG1.42284552
46AURKB1.41118889
47STK31.40339600
48PINK11.39280796
49MUSK1.37851433
50STK391.37388453
51BMPR1B1.33291840
52ZAK1.30673821
53VRK11.30527883
54CHEK11.25783222
55EIF2AK11.23066709
56PDK21.22743306
57CDK71.21246482
58RPS6KB21.19450662
59STK101.19095536
60ERBB31.16238881
61MAP3K81.15512751
62CDK41.15227132
63ITK1.13217192
64CDK91.12714859
65MAPKAPK31.12305925
66WNK31.11614760
67IRAK41.10977780
68BTK1.10802876
69MAP3K141.10518772
70IKBKE1.10376309
71MOS1.10124227
72ATM1.07690038
73RPS6KA41.07354158
74AURKA1.04899556
75PASK1.03441212
76IKBKB1.01383702
77NEK10.96191819
78GRK10.94040014
79NLK0.93507873
80PLK20.89336265
81WNK40.88877767
82CDK20.87084622
83TIE10.81100174
84EIF2AK20.80995768
85PRKCI0.77659187
86SYK0.77044790
87RPS6KA50.76250518
88NUAK10.76214117
89DYRK30.76209673
90PRKCQ0.71800034
91IRAK10.71627022
92CDK60.71104487
93CDK10.70118149
94LYN0.69469052
95KIT0.68331182
96MKNK20.68063301
97STK160.65429298
98STK40.65293672
99MAPK110.64640397
100PAK60.64607946
101VRK20.63882538
102TSSK60.63301766
103ADRBK20.63154818
104TLK10.62726915
105TYK20.61026767
106DYRK20.59971170
107CDK30.58546994
108PIM10.58538995
109FGR0.58373913
110JAK10.57597822
111ALK0.57480839
112FLT30.56806086
113STK380.54448527
114BRD40.53431503
115MAP2K30.52718058
116CCNB10.51813001
117MKNK10.51508938
118PRKD20.51354649
119MAP3K50.51052904
120MAP3K40.49842920
121OXSR10.49705322
122LCK0.48093603
123GRK70.47353610
124BCKDK0.47126179
125CSNK1D0.47108605
126EGFR0.46693009
127MTOR0.45178691
128HCK0.44310862
129MARK30.43626529
130CSNK2A20.41063486
131TNK20.40611562
132MARK20.38220504
133DMPK0.37786841
134MAP3K120.37280481
135CSNK1G20.36546364
136SCYL20.36380835
137PAK30.35722240
138MAPK140.35116312
139FER0.34765425
140PRKDC0.34623465
141MAP4K10.34502270
142MAPK130.34037748
143PRKAA10.33050738
144HIPK20.32548343
145TGFBR10.32092822
146MAPK100.31391717
147CSNK1E0.30790742
148EIF2AK30.30528746
149GSK3B0.30427911
150PAK10.29895892
151AKT30.27122000
152JAK30.26855490
153MAP3K100.25306784
154PNCK0.23366854
155PRKD30.22928500
156SGK20.22196396
157AKT10.21450814
158STK240.20924695
159TYRO30.19302431

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40863953
2Protein export_Homo sapiens_hsa030604.21496947
3Mismatch repair_Homo sapiens_hsa034304.18995065
4Cell cycle_Homo sapiens_hsa041104.06445486
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28539503
6Homologous recombination_Homo sapiens_hsa034403.21288101
7Base excision repair_Homo sapiens_hsa034103.00622493
8RNA transport_Homo sapiens_hsa030133.00186435
9RNA degradation_Homo sapiens_hsa030182.91570033
10RNA polymerase_Homo sapiens_hsa030202.81526472
11Fanconi anemia pathway_Homo sapiens_hsa034602.65946056
12Nucleotide excision repair_Homo sapiens_hsa034202.61737825
13Basal transcription factors_Homo sapiens_hsa030222.60245705
14Regulation of autophagy_Homo sapiens_hsa041402.58756934
15One carbon pool by folate_Homo sapiens_hsa006702.51284182
16Spliceosome_Homo sapiens_hsa030402.34251871
17Propanoate metabolism_Homo sapiens_hsa006402.28612551
18Non-homologous end-joining_Homo sapiens_hsa034502.13773508
19Vitamin B6 metabolism_Homo sapiens_hsa007502.10843413
20Asthma_Homo sapiens_hsa053102.03710595
21Pyrimidine metabolism_Homo sapiens_hsa002402.01568529
22mRNA surveillance pathway_Homo sapiens_hsa030152.01121054
23Allograft rejection_Homo sapiens_hsa053301.95381474
24p53 signaling pathway_Homo sapiens_hsa041151.93081175
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.90223498
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.89346203
27Oxidative phosphorylation_Homo sapiens_hsa001901.88119181
28Oocyte meiosis_Homo sapiens_hsa041141.85225233
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81417470
30Parkinsons disease_Homo sapiens_hsa050121.75419247
31Type I diabetes mellitus_Homo sapiens_hsa049401.72338534
32Graft-versus-host disease_Homo sapiens_hsa053321.71731846
33Autoimmune thyroid disease_Homo sapiens_hsa053201.64488749
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55150061
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53650339
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53385083
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46656533
38Fatty acid elongation_Homo sapiens_hsa000621.42078757
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41061012
40Legionellosis_Homo sapiens_hsa051341.33628174
41Circadian rhythm_Homo sapiens_hsa047101.29679531
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28318517
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28203361
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22299971
45Purine metabolism_Homo sapiens_hsa002301.19936626
46Measles_Homo sapiens_hsa051621.18989576
47Pancreatic cancer_Homo sapiens_hsa052121.16700217
48TGF-beta signaling pathway_Homo sapiens_hsa043501.15009102
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14134159
50Hematopoietic cell lineage_Homo sapiens_hsa046401.13090194
51MicroRNAs in cancer_Homo sapiens_hsa052061.12824311
52Colorectal cancer_Homo sapiens_hsa052101.05288197
53Steroid biosynthesis_Homo sapiens_hsa001001.04089684
54Rheumatoid arthritis_Homo sapiens_hsa053231.03767777
55Huntingtons disease_Homo sapiens_hsa050161.02464061
56Leishmaniasis_Homo sapiens_hsa051401.02157607
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01369961
58Ribosome_Homo sapiens_hsa030100.99432533
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99167686
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98620359
61Epstein-Barr virus infection_Homo sapiens_hsa051690.97396938
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96635021
63Ovarian steroidogenesis_Homo sapiens_hsa049130.94861943
64Viral carcinogenesis_Homo sapiens_hsa052030.93640793
65Herpes simplex infection_Homo sapiens_hsa051680.89857562
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.89305075
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.88568146
68HTLV-I infection_Homo sapiens_hsa051660.84586978
69Butanoate metabolism_Homo sapiens_hsa006500.83896443
70Phototransduction_Homo sapiens_hsa047440.79782199
71Non-small cell lung cancer_Homo sapiens_hsa052230.79524047
72Staphylococcus aureus infection_Homo sapiens_hsa051500.78107247
73Caffeine metabolism_Homo sapiens_hsa002320.77585123
74Selenocompound metabolism_Homo sapiens_hsa004500.76809856
75Thyroid cancer_Homo sapiens_hsa052160.75792139
76Alzheimers disease_Homo sapiens_hsa050100.75444417
77Peroxisome_Homo sapiens_hsa041460.74727777
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.74539995
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.73950623
80mTOR signaling pathway_Homo sapiens_hsa041500.71001258
81Antigen processing and presentation_Homo sapiens_hsa046120.70292439
82Folate biosynthesis_Homo sapiens_hsa007900.69987957
83Bladder cancer_Homo sapiens_hsa052190.68870507
84Hippo signaling pathway_Homo sapiens_hsa043900.68836521
85Small cell lung cancer_Homo sapiens_hsa052220.68264425
86Chronic myeloid leukemia_Homo sapiens_hsa052200.66185461
87Hepatitis B_Homo sapiens_hsa051610.64927720
88Prolactin signaling pathway_Homo sapiens_hsa049170.64629528
89Viral myocarditis_Homo sapiens_hsa054160.63554618
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63350633
91Nitrogen metabolism_Homo sapiens_hsa009100.62986548
92Endometrial cancer_Homo sapiens_hsa052130.62884967
93FoxO signaling pathway_Homo sapiens_hsa040680.62631356
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61705007
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61664670
96Tuberculosis_Homo sapiens_hsa051520.60199111
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58446778
98Choline metabolism in cancer_Homo sapiens_hsa052310.58129196
99Linoleic acid metabolism_Homo sapiens_hsa005910.57789572
100Adherens junction_Homo sapiens_hsa045200.56148977
101Prostate cancer_Homo sapiens_hsa052150.55196264
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54955236
103Fatty acid metabolism_Homo sapiens_hsa012120.54449574
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54323606
105Biosynthesis of amino acids_Homo sapiens_hsa012300.53967360
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53662523
107Notch signaling pathway_Homo sapiens_hsa043300.53249649
108Proteasome_Homo sapiens_hsa030500.51223168
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50529146
110Primary immunodeficiency_Homo sapiens_hsa053400.49803960
111Osteoclast differentiation_Homo sapiens_hsa043800.49725762
112Lysine degradation_Homo sapiens_hsa003100.49563932
113Inositol phosphate metabolism_Homo sapiens_hsa005620.49438786
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48193436
115Renal cell carcinoma_Homo sapiens_hsa052110.47658853
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47545640
117Systemic lupus erythematosus_Homo sapiens_hsa053220.47495285
118GnRH signaling pathway_Homo sapiens_hsa049120.45605275
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44086221
120Platelet activation_Homo sapiens_hsa046110.40343282
121Fatty acid degradation_Homo sapiens_hsa000710.39627136
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39262372
123Tryptophan metabolism_Homo sapiens_hsa003800.38350240
124Dorso-ventral axis formation_Homo sapiens_hsa043200.37634996
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.37338311
126Apoptosis_Homo sapiens_hsa042100.35827659
127African trypanosomiasis_Homo sapiens_hsa051430.35824716
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.35606821
129VEGF signaling pathway_Homo sapiens_hsa043700.34135180
130Metabolic pathways_Homo sapiens_hsa011000.33716195
131Pyruvate metabolism_Homo sapiens_hsa006200.32733683
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32726925
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31923042
134Alcoholism_Homo sapiens_hsa050340.31331423
135Toxoplasmosis_Homo sapiens_hsa051450.31268689
136Olfactory transduction_Homo sapiens_hsa047400.30605747
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30270111
138Estrogen signaling pathway_Homo sapiens_hsa049150.30148567
139Glioma_Homo sapiens_hsa052140.29168864
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29027222
141Wnt signaling pathway_Homo sapiens_hsa043100.27632236
142Ether lipid metabolism_Homo sapiens_hsa005650.26587415
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24737483
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.24515152
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.23362913
146Pathways in cancer_Homo sapiens_hsa052000.23265781
147Pentose phosphate pathway_Homo sapiens_hsa000300.22846562
148ErbB signaling pathway_Homo sapiens_hsa040120.22091536
149Long-term potentiation_Homo sapiens_hsa047200.21163489
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.20695808
151AMPK signaling pathway_Homo sapiens_hsa041520.20064835
152HIF-1 signaling pathway_Homo sapiens_hsa040660.19444011
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19074836
154B cell receptor signaling pathway_Homo sapiens_hsa046620.19018295
155Long-term depression_Homo sapiens_hsa047300.18778358
156MAPK signaling pathway_Homo sapiens_hsa040100.17663528
157Glucagon signaling pathway_Homo sapiens_hsa049220.16944958
158Influenza A_Homo sapiens_hsa051640.16883274
159T cell receptor signaling pathway_Homo sapiens_hsa046600.16458540
160Melanoma_Homo sapiens_hsa052180.16010627
161Type II diabetes mellitus_Homo sapiens_hsa049300.15463094

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