HELT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Notch signaling involved in heart development (GO:0061314)9.47704962
2nephron tubule development (GO:0072080)8.64553454
3response to folic acid (GO:0051593)8.45819478
4multicellular organismal movement (GO:0050879)8.30376716
5musculoskeletal movement (GO:0050881)8.30376716
6lung secretory cell differentiation (GO:0061140)8.04127620
7lipopolysaccharide biosynthetic process (GO:0009103)7.83633108
8cardiac right ventricle morphogenesis (GO:0003215)7.80138846
9intra-S DNA damage checkpoint (GO:0031573)7.72760392
10renal tubule development (GO:0061326)7.72371864
11developmental pigmentation (GO:0048066)7.60584931
12apoptotic DNA fragmentation (GO:0006309)7.10039578
13negative regulation of epidermal cell differentiation (GO:0045605)7.07441445
14lipopolysaccharide metabolic process (GO:0008653)7.01120454
15specification of organ identity (GO:0010092)6.97709014
16nephron epithelium development (GO:0072009)6.92691261
17sympathetic nervous system development (GO:0048485)6.84244647
18negative regulation of interleukin-10 production (GO:0032693)6.61537687
19left/right axis specification (GO:0070986)6.57188030
20Notch receptor processing (GO:0007220)6.56876308
21cellular anion homeostasis (GO:0030002)6.52333124
22negative regulation of oligodendrocyte differentiation (GO:0048715)6.38230722
23neuroblast proliferation (GO:0007405)6.21830929
24regulation of Notch signaling pathway (GO:0008593)5.99647361
25response to muramyl dipeptide (GO:0032495)5.92792010
26cell differentiation in spinal cord (GO:0021515)5.84954031
27cell fate determination (GO:0001709)5.83276363
28DNA replication checkpoint (GO:0000076)5.68790027
29lens fiber cell development (GO:0070307)5.55438633
30heterochromatin organization (GO:0070828)5.51522269
31L-serine metabolic process (GO:0006563)5.50927234
32hair cell differentiation (GO:0035315)5.50204949
33negative regulation of anoikis (GO:2000811)5.48300792
34inner ear receptor cell differentiation (GO:0060113)5.46974962
35atrial cardiac muscle cell action potential (GO:0086014)5.46588973
36reflex (GO:0060004)5.39484149
37glandular epithelial cell differentiation (GO:0002067)5.38363085
38negative regulation of epidermis development (GO:0045683)5.32679569
39negative regulation of potassium ion transmembrane transport (GO:1901380)4.92393253
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.85802282
41segment specification (GO:0007379)4.81272084
42neuron fate specification (GO:0048665)4.78378860
43oligodendrocyte development (GO:0014003)4.77826436
44regulation of development, heterochronic (GO:0040034)4.74966919
45Sertoli cell development (GO:0060009)4.64202447
46spermatid nucleus differentiation (GO:0007289)4.38358954
47negative regulation of glial cell differentiation (GO:0045686)4.37435821
48viral transcription (GO:0019083)4.35070906
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34724287
50negative regulation of cell killing (GO:0031342)4.34724287
51central nervous system neuron development (GO:0021954)4.34030908
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.29995594
53neural crest cell development (GO:0014032)4.20470657
54regulation of anoikis (GO:2000209)4.19013842
55myoblast differentiation (GO:0045445)4.18918653
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.15458428
57regulation of timing of cell differentiation (GO:0048505)4.14525176
58peptidyl-lysine dimethylation (GO:0018027)4.08189415
59viral life cycle (GO:0019058)4.01793909
60translational termination (GO:0006415)4.00011682
61regulation of oligodendrocyte differentiation (GO:0048713)3.97371035
62regulation of G0 to G1 transition (GO:0070316)3.94163829
63cell surface receptor signaling pathway involved in heart development (GO:0061311)3.89595471
64positive regulation of vascular permeability (GO:0043117)3.87641547
65response to lithium ion (GO:0010226)3.85995248
66aorta morphogenesis (GO:0035909)3.83709195
67DNA topological change (GO:0006265)3.81857348
68morphogenesis of an epithelial sheet (GO:0002011)3.81359779
69neuroepithelial cell differentiation (GO:0060563)3.78950900
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78038698
71potassium ion export (GO:0071435)3.77977276
72membrane repolarization during action potential (GO:0086011)3.75669057
73olfactory bulb development (GO:0021772)3.74277188
74regulation of centriole replication (GO:0046599)3.74012770
75response to epidermal growth factor (GO:0070849)3.72374073
76spinal cord association neuron differentiation (GO:0021527)3.72111360
77maternal placenta development (GO:0001893)3.69911377
78cerebral cortex neuron differentiation (GO:0021895)3.67404050
79quinone biosynthetic process (GO:1901663)3.64390645
80ubiquinone biosynthetic process (GO:0006744)3.64390645
81mechanoreceptor differentiation (GO:0042490)3.62371785
82neuron fate commitment (GO:0048663)3.61881218
83lung epithelial cell differentiation (GO:0060487)3.61396264
84Notch signaling pathway (GO:0007219)3.61324500
85mannose metabolic process (GO:0006013)3.59828054
86hypothalamus development (GO:0021854)3.57102881
87forebrain neuron differentiation (GO:0021879)3.57003266
88DNA unwinding involved in DNA replication (GO:0006268)3.56693577
89rRNA modification (GO:0000154)3.54890087
90resolution of meiotic recombination intermediates (GO:0000712)3.51704095
91ubiquinone metabolic process (GO:0006743)3.51615811
92lung cell differentiation (GO:0060479)3.46072387
93mitotic nuclear envelope reassembly (GO:0007084)3.38244136
94nuclear envelope reassembly (GO:0031468)3.38244136
95ethanol oxidation (GO:0006069)3.38171841
96cardiac cell development (GO:0055006)3.35038436
97positive regulation of potassium ion transmembrane transport (GO:1901381)3.34278098
98mesenchymal cell development (GO:0014031)3.34126829
99creatine metabolic process (GO:0006600)3.32456082
100protein maturation by protein folding (GO:0022417)3.31635213
101paraxial mesoderm development (GO:0048339)3.31585573
102negative regulation of microtubule polymerization (GO:0031115)3.30385617
103ribosomal small subunit biogenesis (GO:0042274)3.26816874
104endothelial cell differentiation (GO:0045446)3.26473174
105translational elongation (GO:0006414)3.24905083
106negative regulation of astrocyte differentiation (GO:0048712)3.23362167
107membrane repolarization (GO:0086009)3.22591205
108regulation of membrane repolarization (GO:0060306)3.22236538
109rRNA methylation (GO:0031167)3.19391693
110serine family amino acid biosynthetic process (GO:0009070)3.17907935
111cardiac ventricle morphogenesis (GO:0003208)3.17852729
112kinetochore assembly (GO:0051382)3.17496667
113proximal/distal pattern formation (GO:0009954)3.16185114
114heart trabecula morphogenesis (GO:0061384)3.15133603
115cellular protein complex disassembly (GO:0043624)3.14508593
116cell proliferation in forebrain (GO:0021846)3.14136696
117cardiac muscle contraction (GO:0060048)3.13251634
118neural nucleus development (GO:0048857)3.10713050
119negative regulation of Notch signaling pathway (GO:0045746)3.10272377
120pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10009086
121positive regulation of neural precursor cell proliferation (GO:2000179)3.09658021
122coenzyme catabolic process (GO:0009109)3.08716705
123layer formation in cerebral cortex (GO:0021819)3.08661622
124DNA ligation (GO:0006266)3.07522718
125mitochondrial fusion (GO:0008053)3.07220420
126negative regulation of gliogenesis (GO:0014014)3.04750678
127face development (GO:0060324)3.03745824
128pyrimidine nucleotide catabolic process (GO:0006244)3.02784325
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02440138
130T cell mediated immunity (GO:0002456)3.02351184
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02098355
132positive regulation of p38MAPK cascade (GO:1900745)3.00806566
133pyrimidine nucleobase catabolic process (GO:0006208)2.99627627
134heart valve morphogenesis (GO:0003179)2.97780595
135ventricular cardiac muscle cell action potential (GO:0086005)2.97717357
136neurogenesis (GO:0022008)2.96753197
137regulation of transcription involved in cell fate commitment (GO:0060850)2.96313410
138spliceosomal complex assembly (GO:0000245)2.95727487
139deoxyribonucleotide catabolic process (GO:0009264)2.95591274
140nucleobase catabolic process (GO:0046113)2.95411441
141deoxyribose phosphate catabolic process (GO:0046386)2.95404794
142positive regulation of megakaryocyte differentiation (GO:0045654)2.94371118
143generation of neurons (GO:0048699)2.94335015
144hippocampus development (GO:0021766)2.93747802
145regulation of growth hormone secretion (GO:0060123)2.93664772
1462-deoxyribonucleotide biosynthetic process (GO:0009265)2.93183445
147deoxyribose phosphate biosynthetic process (GO:0046385)2.93183445
148cardiovascular system development (GO:0072358)2.88387032
149mitochondrion morphogenesis (GO:0070584)2.87122537
150replication fork processing (GO:0031297)2.85927008
151regulation of glial cell differentiation (GO:0045685)2.85196268
152establishment of integrated proviral latency (GO:0075713)2.84606830
153stem cell development (GO:0048864)2.83683612
154alpha-linolenic acid metabolic process (GO:0036109)2.82782777
155positive regulation of oligodendrocyte differentiation (GO:0048714)2.82527414
156protein complex localization (GO:0031503)2.82245067
157chromatin remodeling at centromere (GO:0031055)2.82079577
158regulation of NFAT protein import into nucleus (GO:0051532)2.81698079
159purine deoxyribonucleotide catabolic process (GO:0009155)2.81324734
160negative regulation of cell cycle arrest (GO:0071157)2.78753805
161acetyl-CoA metabolic process (GO:0006084)2.78445062
162regulation of protein heterodimerization activity (GO:0043497)2.75875604
163pigmentation (GO:0043473)2.72643262
164cardiac chamber morphogenesis (GO:0003206)2.71873756
165neural crest cell migration (GO:0001755)2.66515988
166positive regulation of growth hormone secretion (GO:0060124)2.66211709
167glial cell development (GO:0021782)2.66195110
168retinal cone cell development (GO:0046549)2.60037441
169activation of MAPKKK activity (GO:0000185)2.53710887
170central nervous system neuron differentiation (GO:0021953)2.53415211
171histone H2B ubiquitination (GO:0033523)2.51824060
172calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49818266
173histone H3-K36 demethylation (GO:0070544)2.47953718
174biotin metabolic process (GO:0006768)2.46531882
175growth hormone secretion (GO:0030252)2.41472666
176regulation of sarcomere organization (GO:0060297)2.40597828
177negative regulation of epithelial cell differentiation (GO:0030857)2.38549380
178DNA integration (GO:0015074)2.37991555
179cerebral cortex development (GO:0021987)2.36976911
180fibroblast migration (GO:0010761)2.30714279
181ganglion development (GO:0061548)13.5972037
182neuronal stem cell maintenance (GO:0097150)12.9630884
183regulation of somitogenesis (GO:0014807)12.7925933
184positive regulation of Notch signaling pathway (GO:0045747)11.1978246
185auditory receptor cell differentiation (GO:0042491)10.5126714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74311173
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.81050368
3TP63_17297297_ChIP-ChIP_HaCaT_Human6.75739149
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.20255235
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.20255235
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.20255235
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65529075
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45085222
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08458457
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01096401
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99633711
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.88093591
13EZH2_22144423_ChIP-Seq_EOC_Human2.67934571
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45357856
15NANOG_18555785_ChIP-Seq_MESCs_Mouse2.35128852
16ZNF274_21170338_ChIP-Seq_K562_Hela2.33439613
17IRF1_19129219_ChIP-ChIP_H3396_Human2.33391037
18SOX2_18555785_ChIP-Seq_MESCs_Mouse2.30654985
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.29426433
20* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.24606515
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22352540
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21887723
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.18475010
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.09847797
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.06743977
26* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04746800
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00248152
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99546256
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.93638444
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84923246
31* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79736487
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78352728
33XRN2_22483619_ChIP-Seq_HELA_Human1.78228054
34* CBX2_27304074_Chip-Seq_ESCs_Mouse1.77555110
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76988388
36* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75978331
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75430368
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.75338740
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74521706
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73652013
41RNF2_27304074_Chip-Seq_NSC_Mouse1.72501237
42* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71448625
43* TP53_20018659_ChIP-ChIP_R1E_Mouse1.66953466
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.65751168
45* EED_16625203_ChIP-ChIP_MESCs_Mouse1.64734868
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64378412
47* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61990559
48* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61768017
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61088395
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.60976642
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59035870
52* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57454897
53* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57454897
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54718245
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.54654534
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54394134
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.53923562
58EGR1_19032775_ChIP-ChIP_M12_Human1.52542185
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.52123740
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.52105711
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51268032
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50624468
63* MYC_18940864_ChIP-ChIP_HL60_Human1.50157860
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.48892522
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47219811
66* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47138054
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46313139
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.45912461
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45049662
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44470558
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41806235
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41334924
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37337689
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37103796
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35937182
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35755772
77ELK1_19687146_ChIP-ChIP_HELA_Human1.35157657
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34179458
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34061184
80LXR_22292898_ChIP-Seq_THP-1_Human1.33725529
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32942370
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32942370
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.31729762
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28158901
85ZNF263_19887448_ChIP-Seq_K562_Human1.23752189
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.23038155
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22157762
88* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21916982
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21064348
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20852468
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20764441
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19395616
93* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19346224
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19164691
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18759483
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18334375
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.17290184
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.16999677
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16497096
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.15556645
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15055009
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.14990323
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14560793
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14523596
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12663563
106* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11971725
107* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11903756
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10404539
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.09315180
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08396668
111REST_21632747_ChIP-Seq_MESCs_Mouse1.07993275
112GABP_19822575_ChIP-Seq_HepG2_Human1.07807389
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05206724
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.03729675
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01149428
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01050461
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99413879
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99028245
119SOX3_22085726_ChIP-Seq_NPCs_Mouse0.98940490
120E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97724728
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97502532
122VDR_21846776_ChIP-Seq_THP-1_Human0.97278208
123SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96833679
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.96231229
125ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95636200
126IGF1R_20145208_ChIP-Seq_DFB_Human0.95572412
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95211526
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94133670
129* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94039943
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93732525
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93500617
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93051201
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92922701
134VDR_23849224_ChIP-Seq_CD4+_Human0.92608173
135TTF2_22483619_ChIP-Seq_HELA_Human0.92251906
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.92174072
137HTT_18923047_ChIP-ChIP_STHdh_Human0.91025855
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90351199
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90148284
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90078232
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90017704
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89807598
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88854886
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88097983
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87810885
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87451607
147* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87208021
148THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86628931
149MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86188093
150POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86181564
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.85908293
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85185508
153AR_21572438_ChIP-Seq_LNCaP_Human0.84319442
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83827168
155RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83752921
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.83597204
157TP53_22573176_ChIP-Seq_HFKS_Human0.83439643
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83081351
159CIITA_25753668_ChIP-Seq_RAJI_Human0.83048429
160TAF15_26573619_Chip-Seq_HEK293_Human0.82057247
161TP53_18474530_ChIP-ChIP_U2OS_Human0.80768330
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80689962
163FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80479235
164TAL1_26923725_Chip-Seq_HPCs_Mouse0.79915616
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76560707
166SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75372012
167VDR_22108803_ChIP-Seq_LS180_Human0.75022908
168PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.72061834
169NFE2_27457419_Chip-Seq_LIVER_Mouse0.70663342
170P300_19829295_ChIP-Seq_ESCs_Human0.69927080
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.68568266
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68192386
173SALL4_22934838_ChIP-ChIP_CD34+_Human0.67798308
174* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67719652
175* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.66400592
176IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.65802519
177CBP_20019798_ChIP-Seq_JUKART_Human0.65802519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.73592026
2MP0008789_abnormal_olfactory_epithelium5.86765009
3MP0005499_abnormal_olfactory_system4.95673572
4MP0005394_taste/olfaction_phenotype4.95673572
5MP0002095_abnormal_skin_pigmentation4.02658561
6MP0000751_myopathy3.90407949
7MP0002653_abnormal_ependyma_morphology3.88871172
8MP0008961_abnormal_basal_metabolism3.54836338
9MP0004133_heterotaxia3.50268842
10MP0003137_abnormal_impulse_conducting3.32987308
11MP0002938_white_spotting3.10678481
12MP0000733_abnormal_muscle_development2.90103017
13MP0002751_abnormal_autonomic_nervous2.79234834
14MP0010030_abnormal_orbit_morphology2.78117222
15MP0005248_abnormal_Harderian_gland2.69843060
16MP0002928_abnormal_bile_duct2.67886915
17MP0003252_abnormal_bile_duct2.67845271
18MP0001346_abnormal_lacrimal_gland2.67219755
19MP0006292_abnormal_olfactory_placode2.46966853
20MP0005646_abnormal_pituitary_gland2.46727332
21MP0000778_abnormal_nervous_system2.35566124
22MP0000566_synostosis2.33388390
23MP0000750_abnormal_muscle_regeneration2.23293838
24MP0005253_abnormal_eye_physiology2.16908346
25MP0002233_abnormal_nose_morphology2.13372410
26MP0000749_muscle_degeneration2.05991200
27MP0005085_abnormal_gallbladder_physiolo2.03796898
28MP0002837_dystrophic_cardiac_calcinosis1.98787944
29MP0000681_abnormal_thyroid_gland1.96453308
30MP0003938_abnormal_ear_development1.95836566
31MP0003011_delayed_dark_adaptation1.94129438
32MP0009379_abnormal_foot_pigmentation1.93438430
33MP0003646_muscle_fatigue1.85377387
34MP0010094_abnormal_chromosome_stability1.85040926
35MP0001293_anophthalmia1.79166434
36MP0006276_abnormal_autonomic_nervous1.76982035
37MP0000049_abnormal_middle_ear1.75079445
38MP0004270_analgesia1.73977113
39MP0000631_abnormal_neuroendocrine_gland1.73619410
40MP0000747_muscle_weakness1.73335286
41MP0001486_abnormal_startle_reflex1.69882894
42MP0002638_abnormal_pupillary_reflex1.68919962
43MP0005391_vision/eye_phenotype1.62111074
44MP0002139_abnormal_hepatobiliary_system1.59806012
45MP0002102_abnormal_ear_morphology1.55960421
46MP0002282_abnormal_trachea_morphology1.52456738
47MP0004858_abnormal_nervous_system1.46641134
48MP0002163_abnormal_gland_morphology1.46240064
49MP0009840_abnormal_foam_cell1.44856046
50MP0004130_abnormal_muscle_cell1.44664533
51MP0003828_pulmonary_edema1.42184372
52MP0002269_muscular_atrophy1.40549122
53MP0001177_atelectasis1.38766215
54MP0004859_abnormal_synaptic_plasticity1.37067115
55MP0002106_abnormal_muscle_physiology1.36099106
56MP0004215_abnormal_myocardial_fiber1.32836561
57MP0002332_abnormal_exercise_endurance1.32479730
58MP0003329_amyloid_beta_deposits1.31870724
59MP0004085_abnormal_heartbeat1.31470600
60MP0003136_yellow_coat_color1.30741228
61* MP0002064_seizures1.29246439
62MP0004036_abnormal_muscle_relaxation1.28968486
63MP0005330_cardiomyopathy1.27688345
64MP0003385_abnormal_body_wall1.24206117
65MP0003635_abnormal_synaptic_transmissio1.23190079
66MP0002152_abnormal_brain_morphology1.22756856
67MP0001270_distended_abdomen1.19388997
68MP0002063_abnormal_learning/memory/cond1.17115007
69MP0000759_abnormal_skeletal_muscle1.14913939
70MP0004084_abnormal_cardiac_muscle1.13399744
71MP0000026_abnormal_inner_ear1.13348330
72MP0005369_muscle_phenotype1.13254147
73MP0000467_abnormal_esophagus_morphology1.12917874
74MP0003861_abnormal_nervous_system1.10269385
75MP0008932_abnormal_embryonic_tissue1.10116489
76MP0003077_abnormal_cell_cycle1.08236616
77MP0000537_abnormal_urethra_morphology1.07379831
78MP0005385_cardiovascular_system_phenoty1.07270373
79MP0001544_abnormal_cardiovascular_syste1.07270373
80MP0004087_abnormal_muscle_fiber1.07143936
81MP0003943_abnormal_hepatobiliary_system1.06878395
82MP0002092_abnormal_eye_morphology1.06579766
83MP0005379_endocrine/exocrine_gland_phen1.05871521
84MP0000428_abnormal_craniofacial_morphol1.05795716
85MP0005365_abnormal_bile_salt1.05426554
86MP0002932_abnormal_joint_morphology1.04113497
87* MP0002067_abnormal_sensory_capabilities1.03117760
88MP0002009_preneoplasia1.01725266
89MP0000762_abnormal_tongue_morphology0.99628172
90MP0004233_abnormal_muscle_weight0.99506938
91MP0002254_reproductive_system_inflammat0.98990711
92* MP0002882_abnormal_neuron_morphology0.97222296
93MP0002972_abnormal_cardiac_muscle0.96991580
94MP0002210_abnormal_sex_determination0.96598419
95MP0005647_abnormal_sex_gland0.96528428
96MP0003315_abnormal_perineum_morphology0.94453587
97MP0003632_abnormal_nervous_system0.94343072
98MP0005410_abnormal_fertilization0.93961724
99MP0002090_abnormal_vision0.93663070
100MP0002108_abnormal_muscle_morphology0.93514734
101MP0005195_abnormal_posterior_eye0.92990119
102MP0003111_abnormal_nucleus_morphology0.92508492
103MP0006072_abnormal_retinal_apoptosis0.91622625
104MP0006138_congestive_heart_failure0.90577528
105MP0004197_abnormal_fetal_growth/weight/0.90410108
106* MP0010769_abnormal_survival0.90282332
107MP0002249_abnormal_larynx_morphology0.88106966
108MP0005332_abnormal_amino_acid0.87782892
109MP0001919_abnormal_reproductive_system0.87671238
110MP0008775_abnormal_heart_ventricle0.87490055
111MP0004811_abnormal_neuron_physiology0.86653212
112* MP0010768_mortality/aging0.86547584
113MP0005197_abnormal_uvea_morphology0.86316899
114MP0002557_abnormal_social/conspecific_i0.86012505
115MP0002184_abnormal_innervation0.85770126
116MP0004147_increased_porphyrin_level0.85018126
117MP0003806_abnormal_nucleotide_metabolis0.84749466
118MP0004145_abnormal_muscle_electrophysio0.84699375
119MP0001915_intracranial_hemorrhage0.84637267
120MP0003866_abnormal_defecation0.84064203
121MP0005620_abnormal_muscle_contractility0.83876702
122* MP0002082_postnatal_lethality0.83562836
123* MP0010770_preweaning_lethality0.83562836
124MP0002572_abnormal_emotion/affect_behav0.82583559
125MP0002127_abnormal_cardiovascular_syste0.81255328
126MP0009745_abnormal_behavioral_response0.80776980
127MP0003279_aneurysm0.80481796
128MP0009046_muscle_twitch0.79648280
129MP0000955_abnormal_spinal_cord0.79546661
130MP0002084_abnormal_developmental_patter0.79169074
131MP0005187_abnormal_penis_morphology0.78806108
132MP0003787_abnormal_imprinting0.77274184
133MP0003948_abnormal_gas_homeostasis0.76796295
134MP0005266_abnormal_metabolism0.76784965
135MP0002111_abnormal_tail_morphology0.75052533
136MP0003959_abnormal_lean_body0.74272854
137MP0002752_abnormal_somatic_nervous0.74053877
138MP0001529_abnormal_vocalization0.68855219
139MP0009703_decreased_birth_body0.64574932
140MP0003890_abnormal_embryonic-extraembry0.60534731
141MP0002075_abnormal_coat/hair_pigmentati0.56970857
142MP0000639_abnormal_adrenal_gland0.56121219
143MP0001286_abnormal_eye_development0.51642902
144MP0005083_abnormal_biliary_tract0.51401389
145MP0002116_abnormal_craniofacial_bone0.51311183
146MP0001764_abnormal_homeostasis0.48120161
147MP0002085_abnormal_embryonic_tissue0.46095271
148MP0003221_abnormal_cardiomyocyte_apopto0.44051415
149MP0003935_abnormal_craniofacial_develop0.42449717
150MP0004043_abnormal_pH_regulation0.40301293
151MP0009697_abnormal_copulation0.39880893
152MP0005193_abnormal_anterior_eye0.36875593
153MP0002877_abnormal_melanocyte_morpholog0.36428495
154MP0001186_pigmentation_phenotype0.35979563
155MP0002081_perinatal_lethality0.34734008
156MP0001943_abnormal_respiration0.34407124
157MP0002114_abnormal_axial_skeleton0.34140084
158MP0000432_abnormal_head_morphology0.33895621
159MP0003984_embryonic_growth_retardation0.31048390
160MP0005380_embryogenesis_phenotype0.30868433
161MP0001672_abnormal_embryogenesis/_devel0.30868433
162MP0002088_abnormal_embryonic_growth/wei0.30711689
163MP0000767_abnormal_smooth_muscle0.29920015
164* MP0002069_abnormal_eating/drinking_beha0.28622753
165MP0003755_abnormal_palate_morphology0.27996678
166MP0003937_abnormal_limbs/digits/tail_de0.27797044
167MP0005220_abnormal_exocrine_pancreas0.27276314
168MP0001944_abnormal_pancreas_morphology0.26553341
169MP0003121_genomic_imprinting0.25481604

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)8.08031023
2Chorioretinal atrophy (HP:0000533)7.91128341
3White forelock (HP:0002211)7.22653232
4Abnormal ciliary motility (HP:0012262)6.94478786
5Vertebral arch anomaly (HP:0008438)6.85340932
6Patchy hypopigmentation of hair (HP:0011365)6.68836011
7Mesangial abnormality (HP:0001966)6.43008641
8Anomalous pulmonary venous return (HP:0010772)6.27495557
9Rib fusion (HP:0000902)5.89361222
10Papillary thyroid carcinoma (HP:0002895)5.82135097
11Tented upper lip vermilion (HP:0010804)5.70366769
12Rhabdomyosarcoma (HP:0002859)5.62473496
13Abnormality of the pulmonary veins (HP:0011718)5.52120942
14Anterior segment dysgenesis (HP:0007700)5.49331661
15Hemivertebrae (HP:0002937)5.43647101
16Hypoplasia of the iris (HP:0007676)5.20087478
17Megalencephaly (HP:0001355)5.06812726
18Supernumerary ribs (HP:0005815)4.85466649
19Septo-optic dysplasia (HP:0100842)4.84681559
20Pulmonary artery stenosis (HP:0004415)4.82906332
21Abnormal respiratory motile cilium physiology (HP:0012261)4.77107844
22Heterochromia iridis (HP:0001100)4.71916204
23Tracheomalacia (HP:0002779)4.64641764
24Narrow nasal bridge (HP:0000446)4.64523018
25Long nose (HP:0003189)4.50268950
26Meningocele (HP:0002435)4.42701540
27Supernumerary bones of the axial skeleton (HP:0009144)4.38276056
28Blue irides (HP:0000635)4.30580643
29Myelomeningocele (HP:0002475)4.25640008
30Prolonged neonatal jaundice (HP:0006579)4.19837290
31Hypoventilation (HP:0002791)4.18332008
32Neoplasm of striated muscle (HP:0009728)4.01754602
33Fibular aplasia (HP:0002990)3.99284783
34Vitreoretinal degeneration (HP:0000655)3.93542979
35Scapular winging (HP:0003691)3.83304542
36Thyroid carcinoma (HP:0002890)3.77534222
37Maternal diabetes (HP:0009800)3.74298302
38Atelectasis (HP:0100750)3.74236085
39Disproportionate short-trunk short stature (HP:0003521)3.73306872
40Abnormality of the septum pellucidum (HP:0007375)3.58358476
41Neuroblastic tumors (HP:0004376)3.38833054
42Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.38833054
43Neuroblastoma (HP:0003006)3.38833054
44Primitive neuroectodermal tumor (HP:0030065)3.38833054
45Abnormality of the intervertebral disk (HP:0005108)3.32647801
46Absent septum pellucidum (HP:0001331)3.31904129
47Cutaneous finger syndactyly (HP:0010554)3.31238359
48Synostosis of carpal bones (HP:0005048)3.10330394
49Abnormal number of incisors (HP:0011064)3.10317995
50Cutaneous syndactyly (HP:0012725)3.05601724
51Abnormality of the musculature of the pelvis (HP:0001469)2.98195665
52Abnormality of the hip-girdle musculature (HP:0001445)2.98195665
53Renal dysplasia (HP:0000110)2.90695914
54Calcaneovalgus deformity (HP:0001848)2.83822391
55Focal motor seizures (HP:0011153)2.83034793
56Hyperventilation (HP:0002883)2.82031118
57Aplasia/hypoplasia of the uterus (HP:0008684)2.80711485
58Premature graying of hair (HP:0002216)2.79771733
59Preauricular pit (HP:0004467)2.77773691
60Periauricular skin pits (HP:0100277)2.77773691
61Abnormality of the shoulder girdle musculature (HP:0001435)2.77307175
62Impulsivity (HP:0100710)2.73721055
63Increased corneal curvature (HP:0100692)2.69868518
64Keratoconus (HP:0000563)2.69868518
65Spinal muscular atrophy (HP:0007269)2.69594467
66Exocrine pancreatic insufficiency (HP:0001738)2.67696160
67Hypercholesterolemia (HP:0003124)2.64395308
68Oligomenorrhea (HP:0000876)2.62276212
69Biconcave vertebral bodies (HP:0004586)2.61982886
70Hyperglycinemia (HP:0002154)2.58516463
71Limb-girdle muscle atrophy (HP:0003797)2.56920966
72Hepatocellular carcinoma (HP:0001402)2.56105837
73Neoplasm of the heart (HP:0100544)2.55990187
74Shoulder girdle muscle weakness (HP:0003547)2.55367269
75Abnormality of the anterior horn cell (HP:0006802)2.55038107
76Degeneration of anterior horn cells (HP:0002398)2.55038107
77Ketosis (HP:0001946)2.53069053
78Large eyes (HP:0001090)2.52058215
79Neuroectodermal neoplasm (HP:0030061)2.47544907
80Neuroepithelial neoplasm (HP:0030063)2.47544907
81Nervous tissue neoplasm (HP:0030060)2.47544907
82Optic nerve hypoplasia (HP:0000609)2.46195316
83Hypoplasia of the ulna (HP:0003022)2.46173741
84Birth length less than 3rd percentile (HP:0003561)2.45409825
85Deformed tarsal bones (HP:0008119)2.44815562
86Abnormality of the renal medulla (HP:0100957)2.42558798
87Abnormal mitochondria in muscle tissue (HP:0008316)2.41735729
88Abnormality of glycine metabolism (HP:0010895)2.41457456
89Abnormality of serine family amino acid metabolism (HP:0010894)2.41457456
90Acute encephalopathy (HP:0006846)2.39802029
91Hepatocellular necrosis (HP:0001404)2.39365553
92Lissencephaly (HP:0001339)2.39097664
93Stridor (HP:0010307)2.37826927
94Selective tooth agenesis (HP:0001592)2.36023218
95Hip dysplasia (HP:0001385)2.35512169
96Aplasia involving bones of the upper limbs (HP:0009823)2.35489502
97Aplasia of the phalanges of the hand (HP:0009802)2.35489502
98Aplasia involving bones of the extremities (HP:0009825)2.35489502
99Spastic paraplegia (HP:0001258)2.35470301
100Coarctation of aorta (HP:0001680)2.35456487
101Delayed CNS myelination (HP:0002188)2.35335275
102Underdeveloped supraorbital ridges (HP:0009891)2.34466447
103Pachygyria (HP:0001302)2.34032803
104Pelvic girdle muscle weakness (HP:0003749)2.32008468
105Acute necrotizing encephalopathy (HP:0006965)2.28555233
106Renal tubular acidosis (HP:0001947)2.27808357
107Ventricular tachycardia (HP:0004756)2.26303023
108Severe short stature (HP:0003510)2.26119900
109Renal hypoplasia (HP:0000089)2.25871600
110Abnormality of the odontoid process (HP:0003310)2.25398577
111Abnormality of the anterior chamber (HP:0000593)2.23340181
112Reticulocytopenia (HP:0001896)2.22629556
113Ketoacidosis (HP:0001993)2.21152274
114Posterior embryotoxon (HP:0000627)2.20872669
115Hepatic necrosis (HP:0002605)2.20795691
116Hemiparesis (HP:0001269)2.19590026
117Supraventricular tachycardia (HP:0004755)2.18516463
118Urinary urgency (HP:0000012)2.16365818
119Malignant neoplasm of the central nervous system (HP:0100836)2.15750819
120Adactyly (HP:0009776)2.13792368
121Abnormality of the line of Schwalbe (HP:0008048)2.13313296
122Primary atrial arrhythmia (HP:0001692)2.12199698
123Supraventricular arrhythmia (HP:0005115)2.11239860
124Polymicrogyria (HP:0002126)2.10158379
125Palpebral edema (HP:0100540)2.08607157
126Rapidly progressive (HP:0003678)2.08572693
127Visual hallucinations (HP:0002367)2.08553852
128Menstrual irregularities (HP:0000858)2.07870046
129Sprengel anomaly (HP:0000912)2.07733025
130Abnormality of the diencephalon (HP:0010662)2.07628748
131Paraplegia (HP:0010550)2.07465447
132Aplasia/Hypoplasia of the fibula (HP:0006492)2.07109083
133Absence seizures (HP:0002121)2.06620099
134Carpal synostosis (HP:0009702)2.06600555
135Spastic diplegia (HP:0001264)2.05973596
136Premature skin wrinkling (HP:0100678)2.05327826
137Rimmed vacuoles (HP:0003805)2.04213936
138Atrioventricular block (HP:0001678)2.04133021
139Diaphragmatic weakness (HP:0009113)2.03967605
140Ulnar deviation of finger (HP:0009465)2.03820338
141Exercise-induced myalgia (HP:0003738)1.94698748
142Progressive macrocephaly (HP:0004481)1.93631708
143Hyperglycinuria (HP:0003108)1.92587481
144Natal tooth (HP:0000695)1.90587331
145Limb dystonia (HP:0002451)1.89966597
146Abnormality of glycolysis (HP:0004366)1.87778591
147Increased serum pyruvate (HP:0003542)1.87778591
148Aganglionic megacolon (HP:0002251)1.87154434
149Hypoplasia of the uterus (HP:0000013)1.86754154
150Aplasia/Hypoplasia of the ulna (HP:0006495)1.86252030
151Esophageal atresia (HP:0002032)1.85584237
152Duplicated collecting system (HP:0000081)1.85235343
153Alacrima (HP:0000522)1.84957024
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84177696
155Retinal dysplasia (HP:0007973)1.84087607
156Myotonia (HP:0002486)1.83283239
157Sudden death (HP:0001699)1.82115312
158Prenatal maternal abnormality (HP:0002686)1.81443206
159Acrocyanosis (HP:0001063)1.81123803
160Smooth philtrum (HP:0000319)1.79761377
161Specific learning disability (HP:0001328)1.79317954
162Gonadotropin excess (HP:0000837)1.79207845
163Neoplasm of the liver (HP:0002896)1.79036645
164Abnormal biliary tract morphology (HP:0012440)1.76452028
165Type II lissencephaly (HP:0007260)1.75723490
166Difficulty climbing stairs (HP:0003551)1.75194386
167Leukodystrophy (HP:0002415)1.74458384
168Abnormality of pyrimidine metabolism (HP:0004353)1.72979315
169Increased CSF lactate (HP:0002490)1.72845502
170Skin pits (HP:0100276)1.72714205
171Cerebellar dysplasia (HP:0007033)1.71803347
172Muscle fiber splitting (HP:0003555)1.71214087
173Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.70807413
174Synostosis involving bones of the hand (HP:0004278)1.70214886
175Pendular nystagmus (HP:0012043)1.69851829
176Pheochromocytoma (HP:0002666)1.68135717
177Atrial fibrillation (HP:0005110)1.67707496
178Growth hormone deficiency (HP:0000824)1.67242695
179Muscle fiber atrophy (HP:0100295)1.65956355
180Hypoplasia of the brainstem (HP:0002365)1.65278744
181Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65278744
182Abnormality of the calf musculature (HP:0001430)1.64392784
183Vertebral fusion (HP:0002948)1.64186764
184Thick lower lip vermilion (HP:0000179)1.64056308
185Thickened helices (HP:0000391)1.63983725
186Intestinal atresia (HP:0011100)1.63576432
187Abnormality of alanine metabolism (HP:0010916)1.63505543
188Hyperalaninemia (HP:0003348)1.63505543
189Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63505543
190Abnormality of the parathyroid morphology (HP:0011766)1.62522733
191Double outlet right ventricle (HP:0001719)1.59801338
192Congenital malformation of the right heart (HP:0011723)1.59801338
193Spina bifida occulta (HP:0003298)1.59555579
194Forearm undergrowth (HP:0009821)1.58300335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L7.63170694
2STK247.12414484
3MAP4K23.48621668
4MAP3K103.37515566
5CDK83.06823819
6EIF2AK13.00273100
7BMPR1B2.82911479
8BUB12.52698733
9CDC72.32329398
10CDK192.19426157
11PRKD32.18660881
12PAK62.13238231
13TLK113.2032267
14EIF2AK31.97801030
15WNK31.90321338
16ILK1.85841439
17MAP2K71.83345349
18STK31.77826828
19MAP3K91.68264446
20DAPK31.60997957
21LMTK21.58996167
22UHMK11.56011900
23VRK11.52033695
24IRAK41.50855745
25EPHA41.47956030
26KSR21.46420647
27BCKDK1.38365342
28CASK1.38148223
29PHKG11.31305115
30PHKG21.31305115
31PRKD21.24879081
32MAP3K41.23622618
33TRIB31.20909015
34MARK11.11280528
35LATS21.10305411
36DYRK21.02445702
37TTN0.94877883
38SIK20.94390219
39CDK30.93602466
40DYRK1A0.92120608
41PINK10.90774054
42TGFBR10.88961623
43CDK90.84899739
44ROCK20.84847376
45STK160.82546967
46SIK30.82523706
47FGFR10.81758587
48EIF2AK20.81245820
49MKNK20.79901794
50CSNK1A1L0.77495627
51MKNK10.75925881
52WEE10.75454610
53CHEK20.75399584
54LIMK10.75326177
55NTRK20.75080844
56KSR10.74922780
57STK380.73522951
58IRAK10.73307429
59PLK40.72920919
60NTRK30.72779288
61BCR0.67914660
62RAF10.67700174
63BRD40.66922940
64ERBB20.65909714
65MAPK150.63852534
66MAP2K10.62419579
67CDK70.62273673
68NME20.61450808
69CSNK1G10.61335160
70ERBB30.60981618
71CDK60.60337404
72SGK4940.59486263
73SGK2230.59486263
74PAK40.59217322
75YES10.58553062
76RPS6KA10.58032533
77CSNK1G20.57017202
78ICK0.56634595
79MARK20.56090124
80MAPK110.56076460
81LRRK20.55886109
82EPHB20.52424708
83MAP2K20.52246626
84PLK20.52043288
85KDR0.49953575
86IKBKE0.49591191
87MAPK130.48265545
88ATR0.48252743
89PRKCG0.48244498
90SRPK10.47383774
91BMX0.45331594
92TYK20.44700042
93AURKB0.44408728
94DAPK10.41846174
95PRKAA10.40215462
96IRAK30.39675811
97PAK30.39578775
98ERBB40.39302319
99NEK60.37806218
100PRKD10.35473482
101RPS6KB10.35469833
102MAP3K70.35271722
103MAPK70.35181946
104NEK20.35053389
105OXSR10.35011471
106PKN10.34193913
107PLK10.33393714
108FGR0.33034411
109GRK10.32976701
110MAPKAPK30.31892329
111MINK10.30057238
112STK390.28882726
113RIPK10.28638104
114PRKAA20.28483368
115CAMK40.27457798
116CSNK1A10.27020447
117DAPK20.26696156
118PDK20.26377016
119AURKA0.26005072
120PLK30.24456028
121CDK40.23940184
122CSNK2A10.23775707
123CDK50.23499513
124NUAK10.23243921
125TESK20.22840145
126DYRK30.21776478
127PRKCH0.21394504
128SIK10.20409930
129MYLK0.20260996
130ROCK10.19696698
131DYRK1B0.19602355
132PRKACB0.18877344
133PNCK0.18687896
134CAMK2B0.18528856
135CDK20.18294038
136CSNK1D0.17600321
137RPS6KA40.17511629
138TESK10.17329538
139RPS6KA30.17286904
140CDK140.16741825
141MAP3K80.16325183
142PRKACA0.16254178
143SRC0.15855427
144CSNK1G30.15828389
145RPS6KB20.15663362
146GSK3B0.15496125
147RPS6KL10.15350998
148RPS6KC10.15350998
149CDK11A0.15318145
150PASK0.15189183
151SGK20.14980365
152BLK0.14822946
153TYRO30.14481927
154IRAK20.14343503
155CHEK10.14267799
156ATM0.14247357
157CDC42BPA0.14083228
158AKT10.14015166
159CDK180.13474458
160CSNK1E0.13312282
161ZAK0.11563591
162MAPK10.11128651
163ADRBK20.10142854
164JAK20.09924112
165CDK10.08939325

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.55204221
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.31620870
3Ribosome_Homo sapiens_hsa030103.18577495
4Spliceosome_Homo sapiens_hsa030403.11339299
5Propanoate metabolism_Homo sapiens_hsa006402.92007475
6DNA replication_Homo sapiens_hsa030302.91958826
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41765521
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31337717
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26409148
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21077127
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19922007
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12417559
13Fatty acid degradation_Homo sapiens_hsa000712.09280392
14Fatty acid elongation_Homo sapiens_hsa000622.06689318
15Parkinsons disease_Homo sapiens_hsa050122.03241699
16Oxidative phosphorylation_Homo sapiens_hsa001901.97217717
17Butanoate metabolism_Homo sapiens_hsa006501.88778390
18Fatty acid metabolism_Homo sapiens_hsa012121.81052430
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80552812
20Cardiac muscle contraction_Homo sapiens_hsa042601.78269172
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73723779
22Biosynthesis of amino acids_Homo sapiens_hsa012301.70909206
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68446361
24Carbon metabolism_Homo sapiens_hsa012001.65590854
25Protein export_Homo sapiens_hsa030601.65376614
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.65326118
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63955384
28Huntingtons disease_Homo sapiens_hsa050161.60218444
29Basal transcription factors_Homo sapiens_hsa030221.59259880
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.52883869
31Mismatch repair_Homo sapiens_hsa034301.51249760
32Lysine degradation_Homo sapiens_hsa003101.50413572
33Alzheimers disease_Homo sapiens_hsa050101.48298220
34Arginine and proline metabolism_Homo sapiens_hsa003301.38920821
35Cell cycle_Homo sapiens_hsa041101.36306186
36Pyruvate metabolism_Homo sapiens_hsa006201.34550016
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.28918247
38Base excision repair_Homo sapiens_hsa034101.28213122
39Dilated cardiomyopathy_Homo sapiens_hsa054141.24187789
40Nitrogen metabolism_Homo sapiens_hsa009101.23849349
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23469819
42Systemic lupus erythematosus_Homo sapiens_hsa053221.23445267
43Basal cell carcinoma_Homo sapiens_hsa052171.18254985
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16392079
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13957580
46beta-Alanine metabolism_Homo sapiens_hsa004101.10112395
47RNA transport_Homo sapiens_hsa030131.05967110
48Notch signaling pathway_Homo sapiens_hsa043301.05632605
49Hedgehog signaling pathway_Homo sapiens_hsa043401.05108201
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04750004
51p53 signaling pathway_Homo sapiens_hsa041151.04278139
52Homologous recombination_Homo sapiens_hsa034401.03753619
53Selenocompound metabolism_Homo sapiens_hsa004501.02542170
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96834875
55Tryptophan metabolism_Homo sapiens_hsa003800.95217620
56Oocyte meiosis_Homo sapiens_hsa041140.94550312
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94495495
58Sulfur relay system_Homo sapiens_hsa041220.90716165
59Sulfur metabolism_Homo sapiens_hsa009200.86081714
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84377017
61Pyrimidine metabolism_Homo sapiens_hsa002400.83779474
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80441314
63Proteasome_Homo sapiens_hsa030500.79154930
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77787782
65Salmonella infection_Homo sapiens_hsa051320.73945731
66mRNA surveillance pathway_Homo sapiens_hsa030150.73662986
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73579998
68Olfactory transduction_Homo sapiens_hsa047400.72905030
69Adherens junction_Homo sapiens_hsa045200.72295859
70Caffeine metabolism_Homo sapiens_hsa002320.71058637
71Alcoholism_Homo sapiens_hsa050340.68912936
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67231065
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65327904
74RNA degradation_Homo sapiens_hsa030180.65040592
75Wnt signaling pathway_Homo sapiens_hsa043100.64334990
76Endometrial cancer_Homo sapiens_hsa052130.62812444
77Hippo signaling pathway_Homo sapiens_hsa043900.62039701
78Prion diseases_Homo sapiens_hsa050200.61279461
79Linoleic acid metabolism_Homo sapiens_hsa005910.59860106
80Regulation of autophagy_Homo sapiens_hsa041400.59761649
81Ether lipid metabolism_Homo sapiens_hsa005650.58792556
82Cocaine addiction_Homo sapiens_hsa050300.57301394
83Fructose and mannose metabolism_Homo sapiens_hsa000510.56963633
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56874521
85PPAR signaling pathway_Homo sapiens_hsa033200.55668035
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53268027
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52757090
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.52003044
89Melanogenesis_Homo sapiens_hsa049160.51332981
90Phenylalanine metabolism_Homo sapiens_hsa003600.50039683
91Nicotine addiction_Homo sapiens_hsa050330.47849438
92Arginine biosynthesis_Homo sapiens_hsa002200.47660132
93Axon guidance_Homo sapiens_hsa043600.47154773
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45046627
95Glycerolipid metabolism_Homo sapiens_hsa005610.43260604
96Fanconi anemia pathway_Homo sapiens_hsa034600.43247495
97Bladder cancer_Homo sapiens_hsa052190.43121756
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42689768
99Gap junction_Homo sapiens_hsa045400.41565838
100Fatty acid biosynthesis_Homo sapiens_hsa000610.40353074
101Glutamatergic synapse_Homo sapiens_hsa047240.40322825
102Inositol phosphate metabolism_Homo sapiens_hsa005620.39440549
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39145645
104Morphine addiction_Homo sapiens_hsa050320.38861334
105Circadian entrainment_Homo sapiens_hsa047130.37748018
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36700332
107Cholinergic synapse_Homo sapiens_hsa047250.35493341
108Pentose phosphate pathway_Homo sapiens_hsa000300.34760195
109Peroxisome_Homo sapiens_hsa041460.34697791
110Prostate cancer_Homo sapiens_hsa052150.32589403
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32198152
112TNF signaling pathway_Homo sapiens_hsa046680.31722214
113Glioma_Homo sapiens_hsa052140.31485248
114GABAergic synapse_Homo sapiens_hsa047270.31336249
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29596954
116Nucleotide excision repair_Homo sapiens_hsa034200.29246774
117MicroRNAs in cancer_Homo sapiens_hsa052060.29002810
118Melanoma_Homo sapiens_hsa052180.28960740
119Fat digestion and absorption_Homo sapiens_hsa049750.28554566
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28144374
121Phototransduction_Homo sapiens_hsa047440.28044859
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.27484438
123Metabolic pathways_Homo sapiens_hsa011000.26997259
124mTOR signaling pathway_Homo sapiens_hsa041500.26161853
125Chemical carcinogenesis_Homo sapiens_hsa052040.25851252
126AMPK signaling pathway_Homo sapiens_hsa041520.25546240
127HTLV-I infection_Homo sapiens_hsa051660.25452400
128TGF-beta signaling pathway_Homo sapiens_hsa043500.25291882
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25182802
130Colorectal cancer_Homo sapiens_hsa052100.24720874
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.24536435
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23720548
133Legionellosis_Homo sapiens_hsa051340.23095771
134Dopaminergic synapse_Homo sapiens_hsa047280.22866465
135Gastric acid secretion_Homo sapiens_hsa049710.22693953
136Primary immunodeficiency_Homo sapiens_hsa053400.22378366
137Complement and coagulation cascades_Homo sapiens_hsa046100.22214936
138Choline metabolism in cancer_Homo sapiens_hsa052310.22195298
139Non-small cell lung cancer_Homo sapiens_hsa052230.21791443
140Tyrosine metabolism_Homo sapiens_hsa003500.20277914
141Tight junction_Homo sapiens_hsa045300.19154683
142Viral myocarditis_Homo sapiens_hsa054160.18972825
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.18506005
144Retinol metabolism_Homo sapiens_hsa008300.15532239
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14657183
146Arachidonic acid metabolism_Homo sapiens_hsa005900.14061852
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.13346260
148Chronic myeloid leukemia_Homo sapiens_hsa052200.13156502

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