HELZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.41364572
2monoubiquitinated protein deubiquitination (GO:0035520)5.40349800
3pre-miRNA processing (GO:0031054)4.77937919
4mitotic sister chromatid cohesion (GO:0007064)4.53421715
5nuclear pore complex assembly (GO:0051292)4.42600152
6nuclear pore organization (GO:0006999)4.25210506
7histone H4-K12 acetylation (GO:0043983)4.21423426
8establishment of protein localization to Golgi (GO:0072600)3.92122323
9protein K11-linked deubiquitination (GO:0035871)3.88843787
10definitive hemopoiesis (GO:0060216)3.88443307
11histone mRNA catabolic process (GO:0071044)3.76714988
12cellular response to ethanol (GO:0071361)3.74567498
13regulation of DNA endoreduplication (GO:0032875)3.62460605
14microtubule anchoring (GO:0034453)3.58927943
15regulation of establishment of cell polarity (GO:2000114)3.58798625
16pore complex assembly (GO:0046931)3.58693051
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.55194132
18regulation of gene silencing by RNA (GO:0060966)3.54597350
19regulation of posttranscriptional gene silencing (GO:0060147)3.54597350
20regulation of gene silencing by miRNA (GO:0060964)3.54597350
21Golgi to endosome transport (GO:0006895)3.53864020
22histone lysine demethylation (GO:0070076)3.53435337
23histone H4-K5 acetylation (GO:0043981)3.52587018
24histone H4-K8 acetylation (GO:0043982)3.52587018
25nucleus localization (GO:0051647)3.51526852
26protein targeting to Golgi (GO:0000042)3.48763405
27positive regulation of granulocyte differentiation (GO:0030854)3.47373784
28negative regulation of histone methylation (GO:0031061)3.47269528
29histone demethylation (GO:0016577)3.42343794
30negative regulation of translation, ncRNA-mediated (GO:0040033)3.38621842
31regulation of translation, ncRNA-mediated (GO:0045974)3.38621842
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38621842
33regulation of histone H3-K27 methylation (GO:0061085)3.36617711
34histone H3-K4 trimethylation (GO:0080182)3.35341951
35protein K48-linked deubiquitination (GO:0071108)3.32027131
36histone H3-K4 methylation (GO:0051568)3.31772291
37genitalia morphogenesis (GO:0035112)3.29235170
38lipid translocation (GO:0034204)3.27775588
39phospholipid translocation (GO:0045332)3.27775588
40N-terminal protein amino acid acetylation (GO:0006474)3.27641319
41histone H4-K16 acetylation (GO:0043984)3.23550813
42positive regulation of developmental pigmentation (GO:0048087)3.19345076
43sister chromatid segregation (GO:0000819)3.19113552
44regulation of pigment cell differentiation (GO:0050932)3.18283725
45regulation of RNA export from nucleus (GO:0046831)3.17840841
46glucocorticoid receptor signaling pathway (GO:0042921)3.15927154
47embryonic retina morphogenesis in camera-type eye (GO:0060059)3.11175046
48regulation of establishment or maintenance of cell polarity (GO:0032878)3.08240380
49protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.07839400
50regulation of histone H3-K9 methylation (GO:0051570)3.07390418
51heterochromatin organization (GO:0070828)3.01229058
52cytoplasmic mRNA processing body assembly (GO:0033962)3.00582837
53paraxial mesoderm development (GO:0048339)3.00511010
54protein demethylation (GO:0006482)2.97682963
55protein dealkylation (GO:0008214)2.97682963
56mitotic sister chromatid segregation (GO:0000070)2.97549602
57regulation of nuclear cell cycle DNA replication (GO:0033262)2.95789537
58V(D)J recombination (GO:0033151)2.91789616
59interleukin-6-mediated signaling pathway (GO:0070102)2.88842915
60embryonic camera-type eye morphogenesis (GO:0048596)2.87581122
61DNA unwinding involved in DNA replication (GO:0006268)2.87328840
62early endosome to late endosome transport (GO:0045022)2.86249626
63histone lysine methylation (GO:0034968)2.82430255
64negative regulation of DNA repair (GO:0045738)2.82337276
65prenylation (GO:0097354)2.82215548
66protein prenylation (GO:0018342)2.82215548
67mitotic nuclear envelope disassembly (GO:0007077)2.81269096
68histone-serine phosphorylation (GO:0035404)2.80592280
69peptidyl-lysine trimethylation (GO:0018023)2.80210274
70positive regulation of mRNA catabolic process (GO:0061014)2.79121868
71histone H4 acetylation (GO:0043967)2.78974246
72hepatocyte apoptotic process (GO:0097284)2.78801548
73positive regulation of gene expression, epigenetic (GO:0045815)2.77310436
74oocyte development (GO:0048599)2.75904709
75regulation of gene silencing (GO:0060968)2.73957267
76mitotic chromosome condensation (GO:0007076)2.71655839
77neural tube formation (GO:0001841)2.71245881
78regulation of B cell receptor signaling pathway (GO:0050855)2.68116816
79kinetochore organization (GO:0051383)2.67825972
80regulation of DNA methylation (GO:0044030)2.67652096
81histone H2A acetylation (GO:0043968)2.67343833
82regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.67307079
83histone H3-K9 methylation (GO:0051567)2.66547866
84histone methylation (GO:0016571)2.66238004
85gene silencing by RNA (GO:0031047)2.66000534
86histone H2A monoubiquitination (GO:0035518)2.65720277
87NLS-bearing protein import into nucleus (GO:0006607)2.63205118
88DNA duplex unwinding (GO:0032508)2.63179740
89nuclear envelope disassembly (GO:0051081)2.63006102
90membrane disassembly (GO:0030397)2.63006102
91DNA damage induced protein phosphorylation (GO:0006975)2.62736370
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62730880
93growth hormone receptor signaling pathway (GO:0060396)2.62669925
94regulation of histone H3-K4 methylation (GO:0051569)2.62354721
95positive regulation of histone H3-K4 methylation (GO:0051571)2.62279101
96DNA geometric change (GO:0032392)2.62266136
97dosage compensation (GO:0007549)2.61267440
98DNA methylation (GO:0006306)2.59814028
99DNA alkylation (GO:0006305)2.59814028
100sister chromatid cohesion (GO:0007062)2.58140518
101negative regulation of histone modification (GO:0031057)2.57108618
102nerve growth factor signaling pathway (GO:0038180)2.56999693
103positive regulation of SMAD protein import into nucleus (GO:0060391)2.56790605
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.56662652
105gastrulation with mouth forming second (GO:0001702)2.56660502
106histone H3-K36 demethylation (GO:0070544)2.56531710
107stress granule assembly (GO:0034063)2.56390590
108positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.54799777
109regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.54799777
110regulation of mRNA catabolic process (GO:0061013)2.53867558
111negative regulation of chromatin modification (GO:1903309)2.51195522
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51187242
113interkinetic nuclear migration (GO:0022027)2.50653960
114gene silencing (GO:0016458)2.50113035
115regulation of chromatin silencing (GO:0031935)2.49657742
116intra-S DNA damage checkpoint (GO:0031573)2.48488533
117protein K63-linked deubiquitination (GO:0070536)2.47744647
118negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.47028666
119peptidyl-threonine phosphorylation (GO:0018107)2.46920154
120regulation of nucleobase-containing compound transport (GO:0032239)2.46424182
121trophectodermal cell differentiation (GO:0001829)2.45624424
122peptidyl-threonine dephosphorylation (GO:0035970)2.45610300
123labyrinthine layer development (GO:0060711)2.44798418
124regulation of histone methylation (GO:0031060)2.43907964
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43529653
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.43529653
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.43529653
128regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.43304722
129positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.43304722
130cellular response to growth hormone stimulus (GO:0071378)2.43046724
131embryonic hemopoiesis (GO:0035162)2.42290361
132regulation of translational fidelity (GO:0006450)2.42023368
133chromatin assembly (GO:0031497)2.41937251
134negative T cell selection (GO:0043383)2.41749154
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.41588492
136regulation of protein polyubiquitination (GO:1902914)2.41058667
137mRNA splice site selection (GO:0006376)2.38934306
138COPII vesicle coating (GO:0048208)2.38753469
139male sex determination (GO:0030238)2.38658574
140activated T cell proliferation (GO:0050798)2.38368109
141corticosteroid receptor signaling pathway (GO:0031958)2.37662542
142histone acetylation (GO:0016573)2.37465183
143establishment of nucleus localization (GO:0040023)2.37076936
144kinetochore assembly (GO:0051382)2.35922337
145positive regulation of mRNA 3-end processing (GO:0031442)2.35571159
146rRNA catabolic process (GO:0016075)2.35077813
147positive regulation of RNA splicing (GO:0033120)2.34317195
148chromatin silencing (GO:0006342)2.34172819
149DNA methylation or demethylation (GO:0044728)2.34082613
150protein localization to kinetochore (GO:0034501)2.33522528
151snRNA processing (GO:0016180)2.33497773
152positive T cell selection (GO:0043368)2.33368973
153histone H3-K9 modification (GO:0061647)2.32076676
154regulation of telomere maintenance via telomerase (GO:0032210)2.29927697
155meiotic chromosome segregation (GO:0045132)2.28893792
156genetic imprinting (GO:0071514)2.28431686
157histone H3-K9 demethylation (GO:0033169)2.26937021
158regulation of centriole replication (GO:0046599)2.26629443
159regulation of telomere maintenance (GO:0032204)2.26284806
160peptidyl-lysine methylation (GO:0018022)2.25824057
161internal peptidyl-lysine acetylation (GO:0018393)2.25531947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22784297
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.54393368
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22677712
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.23497402
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07928030
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98632486
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.84632783
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65947131
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58497883
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53237553
11MYC_22102868_ChIP-Seq_BL_Human2.53229657
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38085901
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38085901
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38085901
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26456809
16GBX2_23144817_ChIP-Seq_PC3_Human2.22692032
17CIITA_25753668_ChIP-Seq_RAJI_Human2.16054999
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.15860645
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12537897
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10671227
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06278579
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03768871
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97393775
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91625735
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89686436
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88884366
27IGF1R_20145208_ChIP-Seq_DFB_Human1.88130966
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85205907
29AR_21572438_ChIP-Seq_LNCaP_Human1.80479364
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80147244
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.79943662
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79027220
33* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78185457
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77788281
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76610410
36ER_23166858_ChIP-Seq_MCF-7_Human1.75235672
37* TAF15_26573619_Chip-Seq_HEK293_Human1.74143171
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70782044
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70395361
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67387658
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66942815
42AHR_22903824_ChIP-Seq_MCF-7_Human1.65212493
43FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.64342179
44TP53_16413492_ChIP-PET_HCT116_Human1.63168316
45PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62006892
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.61491088
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.60905121
48* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59025751
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58329086
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57387660
51GATA1_22025678_ChIP-Seq_K562_Human1.55691353
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54716447
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54261724
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.53596229
55TCF4_23295773_ChIP-Seq_U87_Human1.52212497
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.52182887
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51862811
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51046016
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47456278
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47274303
61P300_19829295_ChIP-Seq_ESCs_Human1.45777632
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.45362944
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42149365
64* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41835124
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41507485
66* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40362553
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.40105592
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38198193
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37285925
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35587932
71ZNF274_21170338_ChIP-Seq_K562_Hela1.35106080
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34746777
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33823454
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.32983970
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32581449
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.32176411
77TCF7_22412390_ChIP-Seq_EML_Mouse1.32053953
78* FLI1_21867929_ChIP-Seq_TH2_Mouse1.31680438
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30053463
80* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29865386
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29054687
82* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.28931491
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28151739
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28019521
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26406226
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26246485
87CBP_20019798_ChIP-Seq_JUKART_Human1.26246485
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26082325
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.25441374
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25062704
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23797512
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23441739
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23360403
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22888843
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20787205
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.20672420
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20337959
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19562256
99* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19115139
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19106816
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18750495
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18705645
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17462582
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.17214436
105* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16430589
106SCL_19346495_ChIP-Seq_HPC-7_Human1.16298297
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16171159
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15714562
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.15374756
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15007500
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14971163
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14603992
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14603992
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14304661
115POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13809649
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13564243
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.11301266
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09248980
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.09214790
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09126641
121* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07665918
122AR_25329375_ChIP-Seq_VCAP_Human1.07199502
123IRF8_22096565_ChIP-ChIP_GC-B_Human1.06809025
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06710284
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06514014
126KDM2B_26808549_Chip-Seq_DND41_Human1.06024879
127CDX2_22108803_ChIP-Seq_LS180_Human1.04660614
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04183034
129RUNX2_22187159_ChIP-Seq_PCA_Human1.04087255
130VDR_22108803_ChIP-Seq_LS180_Human1.03853010
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03401426
132TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02601168
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02559589
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.02450632
135* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02185370
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.01811525
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01529099
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01529099
139NOTCH1_21737748_ChIP-Seq_TLL_Human1.00965566
140PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00703963
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99636408
142BCAT_22108803_ChIP-Seq_LS180_Human0.99523623
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98385194
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98287105
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98099118
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.97995134
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97823167
148FUS_26573619_Chip-Seq_HEK293_Human0.97326191
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95790117
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95104480
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92897402
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91827971
153* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90496825
154AR_21909140_ChIP-Seq_LNCAP_Human0.90322598
155EWS_26573619_Chip-Seq_HEK293_Human0.90062856
156PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89855301
157NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87508868
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87206544
159CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87050168
160KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86969504
161ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83736697
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83492116
163SOX2_16153702_ChIP-ChIP_HESCs_Human0.83390612
164PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83110689
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.83083944
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.82679892
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81689150
168SOX9_26525672_Chip-Seq_HEART_Mouse0.79550569
169ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79550350
170KDM5A_27292631_Chip-Seq_BREAST_Human0.79330010
171RUNX_20019798_ChIP-Seq_JUKART_Human0.79274418
172* STAT3_23295773_ChIP-Seq_U87_Human0.79160604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.36957089
2MP0008057_abnormal_DNA_replication3.11141230
3MP0003121_genomic_imprinting3.08524186
4MP0003122_maternal_imprinting2.96499985
5MP0003787_abnormal_imprinting2.83113581
6MP0010094_abnormal_chromosome_stability2.58537036
7MP0003123_paternal_imprinting2.56679824
8MP0004381_abnormal_hair_follicle2.51328719
9MP0003111_abnormal_nucleus_morphology2.28568994
10MP0010352_gastrointestinal_tract_polyps2.10536461
11MP0000569_abnormal_digit_pigmentation2.08966228
12MP0003890_abnormal_embryonic-extraembry2.08757727
13MP0005076_abnormal_cell_differentiation2.07889704
14MP0003195_calcinosis2.04075769
15MP0005075_abnormal_melanosome_morpholog2.01105457
16MP0003077_abnormal_cell_cycle2.00898710
17MP0000015_abnormal_ear_pigmentation1.97153740
18MP0000383_abnormal_hair_follicle1.90057266
19MP0004957_abnormal_blastocyst_morpholog1.85062865
20MP0003693_abnormal_embryo_hatching1.80277073
21MP0008007_abnormal_cellular_replicative1.68213191
22MP0002084_abnormal_developmental_patter1.65836460
23MP0010678_abnormal_skin_adnexa1.59398198
24MP0002653_abnormal_ependyma_morphology1.59198928
25MP0000372_irregular_coat_pigmentation1.58456366
26MP0005380_embryogenesis_phenotype1.58397414
27MP0001672_abnormal_embryogenesis/_devel1.58397414
28MP0005408_hypopigmentation1.56856485
29MP0003984_embryonic_growth_retardation1.55947113
30MP0008058_abnormal_DNA_repair1.55394122
31MP0002088_abnormal_embryonic_growth/wei1.53175831
32MP0004197_abnormal_fetal_growth/weight/1.52296584
33MP0003941_abnormal_skin_development1.52232801
34MP0000350_abnormal_cell_proliferation1.51800969
35MP0003119_abnormal_digestive_system1.51257606
36MP0009780_abnormal_chondrocyte_physiolo1.51091108
37MP0003943_abnormal_hepatobiliary_system1.49174101
38MP0002085_abnormal_embryonic_tissue1.48923652
39MP0004808_abnormal_hematopoietic_stem1.48325032
40MP0002086_abnormal_extraembryonic_tissu1.46679491
41MP0001730_embryonic_growth_arrest1.46061042
42MP0009697_abnormal_copulation1.46025175
43MP0000516_abnormal_urinary_system1.45277325
44MP0005367_renal/urinary_system_phenotyp1.45277325
45MP0000371_diluted_coat_color1.44245592
46MP0001697_abnormal_embryo_size1.39741460
47MP0003868_abnormal_feces_composition1.37882144
48MP0002009_preneoplasia1.36638488
49MP0000427_abnormal_hair_cycle1.34639335
50MP0006292_abnormal_olfactory_placode1.34017179
51MP0002006_tumorigenesis1.32675428
52MP0004264_abnormal_extraembryonic_tissu1.31515692
53MP0003567_abnormal_fetal_cardiomyocyte1.30778419
54MP0008995_early_reproductive_senescence1.30444649
55MP0003786_premature_aging1.29144485
56MP0003935_abnormal_craniofacial_develop1.28345416
57MP0009703_decreased_birth_body1.26580107
58MP0003656_abnormal_erythrocyte_physiolo1.23639133
59MP0005623_abnormal_meninges_morphology1.23556257
60MP0003221_abnormal_cardiomyocyte_apopto1.23484362
61MP0001293_anophthalmia1.22501854
62MP0002102_abnormal_ear_morphology1.22284534
63MP0008961_abnormal_basal_metabolism1.21581224
64MP0005187_abnormal_penis_morphology1.20297500
65MP0005409_darkened_coat_color1.20132984
66MP0002396_abnormal_hematopoietic_system1.18161931
67MP0009115_abnormal_fat_cell1.17592761
68MP0004233_abnormal_muscle_weight1.17469054
69MP0000428_abnormal_craniofacial_morphol1.15286343
70MP0002925_abnormal_cardiovascular_devel1.14885628
71MP0004133_heterotaxia1.12340118
72MP0004134_abnormal_chest_morphology1.12065001
73MP0004883_abnormal_blood_vessel1.11699100
74MP0010307_abnormal_tumor_latency1.11379146
75MP0004130_abnormal_muscle_cell1.09807251
76MP0000703_abnormal_thymus_morphology1.07614702
77MP0006072_abnormal_retinal_apoptosis1.07259105
78MP0002080_prenatal_lethality1.05683132
79MP0000537_abnormal_urethra_morphology1.05583759
80MP0001188_hyperpigmentation1.02680337
81MP0003115_abnormal_respiratory_system0.99941345
82MP0003861_abnormal_nervous_system0.99453615
83MP0003950_abnormal_plasma_membrane0.97932837
84MP0002928_abnormal_bile_duct0.96735578
85MP0000432_abnormal_head_morphology0.96452037
86MP0004484_altered_response_of0.95025481
87MP0002168_other_aberrant_phenotype0.94247421
88MP0008932_abnormal_embryonic_tissue0.93380889
89MP0003763_abnormal_thymus_physiology0.92341463
90MP0003045_fibrosis0.90899885
91MP0001666_abnormal_nutrient_absorption0.89503841
92MP0010030_abnormal_orbit_morphology0.89487137
93MP0001915_intracranial_hemorrhage0.88913313
94MP0001324_abnormal_eye_pigmentation0.88399424
95MP0003385_abnormal_body_wall0.87776480
96MP0000266_abnormal_heart_morphology0.87648802
97MP0004084_abnormal_cardiac_muscle0.86540530
98MP0002116_abnormal_craniofacial_bone0.85302234
99MP0005220_abnormal_exocrine_pancreas0.83451983
100MP0002127_abnormal_cardiovascular_syste0.83356029
101MP0001286_abnormal_eye_development0.83335608
102MP0010329_abnormal_lipoprotein_level0.83192949
103MP0001851_eye_inflammation0.82880319
104MP0000003_abnormal_adipose_tissue0.82857726
105MP0009278_abnormal_bone_marrow0.82335497
106MP0002160_abnormal_reproductive_system0.80712819
107MP0002095_abnormal_skin_pigmentation0.80683248
108MP0003252_abnormal_bile_duct0.78959026
109MP0003755_abnormal_palate_morphology0.78943477
110MP0003283_abnormal_digestive_organ0.78420353
111MP0006054_spinal_hemorrhage0.78396607
112MP0009053_abnormal_anal_canal0.78245899
113MP0002210_abnormal_sex_determination0.78072186
114MP0003566_abnormal_cell_adhesion0.77855113
115MP0001784_abnormal_fluid_regulation0.77498192
116MP0003937_abnormal_limbs/digits/tail_de0.76605870
117MP0003942_abnormal_urinary_system0.75528281
118MP0001661_extended_life_span0.74954311
119MP0000689_abnormal_spleen_morphology0.72926954
120MP0000678_abnormal_parathyroid_gland0.72912667
121MP0005621_abnormal_cell_physiology0.72280741
122MP0002166_altered_tumor_susceptibility0.72059411
123MP0003091_abnormal_cell_migration0.71715128
124MP0002697_abnormal_eye_size0.71632769
125MP0002398_abnormal_bone_marrow0.71551841
126MP0002114_abnormal_axial_skeleton0.71316231
127MP0003705_abnormal_hypodermis_morpholog0.71107167
128MP0000313_abnormal_cell_death0.70706079
129MP0010630_abnormal_cardiac_muscle0.70402352
130MP0003632_abnormal_nervous_system0.70331041
131MP0009672_abnormal_birth_weight0.68847868
132MP0001145_abnormal_male_reproductive0.67585748
133MP0002075_abnormal_coat/hair_pigmentati0.67438108
134MP0002722_abnormal_immune_system0.67292773
135MP0001929_abnormal_gametogenesis0.67230001
136MP0001849_ear_inflammation0.67088590
137MP0000631_abnormal_neuroendocrine_gland0.66806992
138MP0002081_perinatal_lethality0.66417209
139MP0003172_abnormal_lysosome_physiology0.65935483
140MP0005389_reproductive_system_phenotype0.65371347
141MP0005174_abnormal_tail_pigmentation0.65253838
142MP0005395_other_phenotype0.65114668
143MP0008770_decreased_survivor_rate0.64772606
144MP0003936_abnormal_reproductive_system0.64727330
145MP0003828_pulmonary_edema0.64002453
146MP0000534_abnormal_ureter_morphology0.63990713
147MP0001545_abnormal_hematopoietic_system0.61769261
148MP0005397_hematopoietic_system_phenotyp0.61769261
149MP0001119_abnormal_female_reproductive0.61646697
150MP0005171_absent_coat_pigmentation0.60219923
151MP0003699_abnormal_female_reproductive0.59617994
152MP0005379_endocrine/exocrine_gland_phen0.59214351

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.75343951
2Abnormality of the fingertips (HP:0001211)3.51874931
3Thyroid carcinoma (HP:0002890)3.38687279
4Acute myeloid leukemia (HP:0004808)3.10879861
5Long eyelashes (HP:0000527)2.96632410
6Neoplasm of the oral cavity (HP:0100649)2.90686894
7Curly hair (HP:0002212)2.89856799
8T lymphocytopenia (HP:0005403)2.89344455
9Fair hair (HP:0002286)2.88896263
10Embryonal renal neoplasm (HP:0011794)2.83774902
11Ependymoma (HP:0002888)2.82926951
12Short 4th metacarpal (HP:0010044)2.79718463
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79718463
14Abnormality of the labia minora (HP:0012880)2.77195876
15Blue irides (HP:0000635)2.72423679
16Heterotopia (HP:0002282)2.66293296
17Medulloblastoma (HP:0002885)2.63789085
18Anal stenosis (HP:0002025)2.62886005
19Abnormality of T cell number (HP:0011839)2.61359119
20Subacute progressive viral hepatitis (HP:0006572)2.61314037
21Abnormality of the nasal septum (HP:0000419)2.58018601
22Trigonocephaly (HP:0000243)2.57775200
23Generalized hypopigmentation of hair (HP:0011358)2.57432103
24Astrocytoma (HP:0009592)2.56324746
25Abnormality of the astrocytes (HP:0100707)2.56324746
26Chronic hepatic failure (HP:0100626)2.53251272
27Hyperventilation (HP:0002883)2.48717286
28Ectopic kidney (HP:0000086)2.48433259
29Supernumerary ribs (HP:0005815)2.45585019
30Hypoplastic labia majora (HP:0000059)2.43992335
31Chromsome breakage (HP:0040012)2.39776525
32Gaze-evoked nystagmus (HP:0000640)2.38957600
33Truncal obesity (HP:0001956)2.38766585
34Supernumerary bones of the axial skeleton (HP:0009144)2.28772169
35Deep philtrum (HP:0002002)2.28124635
36Increased nuchal translucency (HP:0010880)2.27747650
37Broad thumb (HP:0011304)2.24795704
38Stomach cancer (HP:0012126)2.24587926
39Urethral obstruction (HP:0000796)2.23328736
40Glioma (HP:0009733)2.22866465
41Cystic hygroma (HP:0000476)2.21279350
42Deviation of the thumb (HP:0009603)2.21230518
43Renal cortical cysts (HP:0000803)2.20693952
44Narrow palate (HP:0000189)2.19061805
45Widely spaced teeth (HP:0000687)2.19022066
46Skull defect (HP:0001362)2.14854382
47Proximal placement of thumb (HP:0009623)2.14707536
48Abnormality of the labia majora (HP:0012881)2.12629549
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12515296
50Hepatoblastoma (HP:0002884)2.12068545
51Obsessive-compulsive behavior (HP:0000722)2.12002587
52Neonatal hypoglycemia (HP:0001998)2.10876221
53Hypoplastic iliac wings (HP:0002866)2.09795005
54Macroorchidism (HP:0000053)2.09148376
55Transitional cell carcinoma of the bladder (HP:0006740)2.07703015
56Broad palm (HP:0001169)2.05207587
57Neoplasm of the adrenal cortex (HP:0100641)2.04513386
58Neoplasm of the heart (HP:0100544)2.04101945
59Abnormality of the left ventricular outflow tract (HP:0011103)2.03258027
60Subaortic stenosis (HP:0001682)2.03258027
61Prominent nose (HP:0000448)2.01573601
62Poor coordination (HP:0002370)2.00123985
63Hypoplasia of the maxilla (HP:0000327)1.99919997
64Shawl scrotum (HP:0000049)1.99912978
65Renal duplication (HP:0000075)1.98003459
66Intestinal fistula (HP:0100819)1.97002960
67Bladder carcinoma (HP:0002862)1.96780099
68Bladder neoplasm (HP:0009725)1.96780099
69Abnormality of the renal cortex (HP:0011035)1.95871219
70Abnormal number of incisors (HP:0011064)1.95632485
71Aplasia/Hypoplasia of the sternum (HP:0006714)1.95107422
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94864380
73Neoplasm of striated muscle (HP:0009728)1.94694562
74Skin tags (HP:0010609)1.93438172
75Genetic anticipation (HP:0003743)1.92346408
76Abnormality of the parietal bone (HP:0002696)1.91099443
77Broad phalanges of the hand (HP:0009768)1.90989463
78Submucous cleft hard palate (HP:0000176)1.89874714
79Short chin (HP:0000331)1.88012009
80Acute lymphatic leukemia (HP:0006721)1.86216080
81Acanthocytosis (HP:0001927)1.85664808
82Hip dysplasia (HP:0001385)1.85337622
83Sparse scalp hair (HP:0002209)1.83957070
84Diastasis recti (HP:0001540)1.83365764
85Colon cancer (HP:0003003)1.83336735
86Midline defect of the nose (HP:0004122)1.82702813
87Clubbing of toes (HP:0100760)1.82520506
88Coarse hair (HP:0002208)1.82375737
89Oligodactyly (HP:0012165)1.81669867
90Drooling (HP:0002307)1.81296893
91Papillary thyroid carcinoma (HP:0002895)1.81079484
92Vertebral arch anomaly (HP:0008438)1.81026230
93Abnormality of incisor morphology (HP:0011063)1.80972017
94Abnormality of the 4th metacarpal (HP:0010012)1.80670077
95Dislocated radial head (HP:0003083)1.80058667
96Hematochezia (HP:0002573)1.79774550
97Tubulointerstitial nephritis (HP:0001970)1.79766504
98Broad finger (HP:0001500)1.77632959
99Hyperkalemia (HP:0002153)1.77280214
100Gingival bleeding (HP:0000225)1.76364050
101Aqueductal stenosis (HP:0002410)1.75733814
102Lip pit (HP:0100267)1.75599975
103Abnormality of the wing of the ilium (HP:0011867)1.75537860
104Hyperacusis (HP:0010780)1.75139334
105Large earlobe (HP:0009748)1.74467110
106Neoplasm of the tracheobronchial system (HP:0100552)1.73071178
107Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72243367
108Hypopigmentation of the fundus (HP:0007894)1.72125107
109Labial hypoplasia (HP:0000066)1.71292537
110Low anterior hairline (HP:0000294)1.71188741
111Rib fusion (HP:0000902)1.70924394
112Abnormality of the sella turcica (HP:0002679)1.70148490
113Excessive salivation (HP:0003781)1.70067821
114Smooth philtrum (HP:0000319)1.69787218
115Abnormality of the epiphyses of the hand (HP:0005924)1.68931224
116Abnormality of the radial head (HP:0003995)1.68415270
117Protruding tongue (HP:0010808)1.67731716
118Biliary tract neoplasm (HP:0100574)1.67451010
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.67091155
120Embryonal neoplasm (HP:0002898)1.67020995
121Hypoplasia of the thymus (HP:0000778)1.66601143
122Wide intermamillary distance (HP:0006610)1.65265412
123Leiomyosarcoma (HP:0100243)1.64071246
124Uterine leiomyosarcoma (HP:0002891)1.64071246
125Tapered finger (HP:0001182)1.63924582
126Selective tooth agenesis (HP:0001592)1.63838909
127Asymmetry of the thorax (HP:0001555)1.63705762
128Autoimmune hemolytic anemia (HP:0001890)1.63236048
129Thick eyebrow (HP:0000574)1.62829980
130Preauricular skin tag (HP:0000384)1.62466467
131Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.62245802
132Freckling (HP:0001480)1.61896388
133Abnormal pancreas size (HP:0012094)1.61706662
134Broad phalanx (HP:0006009)1.61356828
135Cubitus valgus (HP:0002967)1.61317538
136Abnormal biliary tract morphology (HP:0012440)1.60413185
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.59420138
138Cafe-au-lait spot (HP:0000957)1.59211807
139Gastrointestinal carcinoma (HP:0002672)1.58463506
140Malignant gastrointestinal tract tumors (HP:0006749)1.58463506
141Basal cell carcinoma (HP:0002671)1.57988474
142Abnormality of the carotid arteries (HP:0005344)1.57093148
143Dysmetric saccades (HP:0000641)1.56656234
144Sandal gap (HP:0001852)1.56211845
145Hypoplastic female external genitalia (HP:0012815)1.55161705
146Intestinal atresia (HP:0011100)1.55031749
147Cutis marmorata (HP:0000965)1.54833096
148Meckel diverticulum (HP:0002245)1.54462844
149Pointed chin (HP:0000307)1.54318136
150Birth length less than 3rd percentile (HP:0003561)1.53787108
151Short phalanx of the thumb (HP:0009660)1.52641279
152Abnormality of the ileum (HP:0001549)1.52575272
153Abnormality of the incisor (HP:0000676)1.52463410
154Rhabdomyosarcoma (HP:0002859)1.52254814
155Abnormality of chromosome stability (HP:0003220)1.51953425
156Missing ribs (HP:0000921)1.51399431
157Abnormal hair whorl (HP:0010721)1.51342769
158Attention deficit hyperactivity disorder (HP:0007018)1.50931016
159Broad long bones (HP:0005622)1.50803854
160Patellar aplasia (HP:0006443)1.48611574
161Nephroblastoma (Wilms tumor) (HP:0002667)1.48113057
162Abnormality of the columella (HP:0009929)1.47414486
163Abnormality of chromosome segregation (HP:0002916)1.46794436
164Thyroiditis (HP:0100646)1.46700743
165Dental malocclusion (HP:0000689)1.45812254
166Short humerus (HP:0005792)1.45453330
167Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.45300753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.90279043
2BRD44.69018495
3FRK3.93692487
4CDC72.99280332
5TAOK32.84437501
6AKT32.55365691
7SIK32.11224156
8TNIK1.90922222
9LATS11.88227551
10TSSK61.87579862
11CAMK1G1.79274677
12MKNK21.75783008
13CAMK1D1.74482201
14PIK3CA1.73947490
15NEK21.72840981
16CDK71.69121352
17SIK21.68928091
18PNCK1.65882724
19MAP3K101.63373880
20ATR1.57781855
21MTOR1.54006173
22CASK1.46763283
23EEF2K1.39711649
24STK391.38823220
25MAP3K21.34841372
26CDK91.31625844
27ACVR1B1.30447683
28CHEK11.29795450
29ATM1.27687305
30PLK31.27615608
31EIF2AK31.20174178
32TRPM71.18063297
33NTRK31.17644798
34CDC42BPA1.17393985
35CDK41.16005821
36FGFR21.15481758
37SGK2231.13896316
38SGK4941.13896316
39BMPR1B1.12571187
40ICK1.12448517
41TTK1.11892126
42ALK1.11453472
43JAK11.11264550
44MKNK11.10988876
45PASK1.09439255
46PDGFRA1.08645511
47CHEK21.08367289
48RPS6KB21.04605853
49TEC1.03173833
50CDK21.02783429
51TYRO31.00977333
52FER1.00822372
53SGK31.00818734
54ERBB31.00089286
55SGK21.00088057
56STK38L0.98308294
57NEK60.98182324
58NUAK10.98138468
59PLK10.97252969
60WEE10.97117621
61PKN20.96213990
62OBSCN0.95373734
63FGFR30.92710023
64DMPK0.92555716
65PAK30.90163902
66PIK3CG0.88256252
67CDK60.85598194
68MELK0.85364916
69RET0.85290007
70CAMKK20.84312833
71MAPK140.82950480
72CDK10.81693454
73FGFR10.80650537
74PDGFRB0.78340273
75MAP3K40.77479967
76SRPK10.77031742
77WNK10.76872799
78CDK30.76571342
79TXK0.74211250
80STK100.73474874
81STK380.72625736
82* GSK3B0.72612596
83STK40.72411584
84PRKDC0.72192187
85CAMK40.72070136
86STK30.71618433
87PRKAA20.71287104
88NEK10.70539704
89CHUK0.70492476
90EPHA20.69676917
91SIK10.68472634
92WNK40.68418595
93CDK80.68103336
94MAP3K50.67852509
95FGFR40.67676088
96MAPK70.67038549
97YES10.66134570
98HCK0.65547993
99MAP3K70.64560599
100MAPK100.64016695
101KSR10.63722940
102AKT10.63588061
103MARK20.62941476
104ERBB20.62890753
105PRKD30.61739966
106MAPK10.61016723
107CSNK1E0.59031784
108ITK0.58962971
109TLK10.58888347
110MAP2K60.58685102
111RPS6KB10.58550616
112BLK0.58006673
113MAPK110.57895939
114STK110.57694049
115NLK0.57630644
116EPHA30.57437345
117PRKAA10.56867270
118AURKB0.56375581
119IKBKE0.55422713
120BCR0.54614774
121CSNK1D0.54411266
122SGK10.53899058
123MAPK80.53639486
124HIPK20.53471664
125MARK30.52769132
126PRKD20.52600931
127FES0.52385596
128PIM10.50820792
129AKT20.50673792
130DYRK1A0.48000479
131BTK0.45762120
132TGFBR10.45740301
133FLT30.45727088
134MAPK130.44661571
135CAMK10.44265271
136EGFR0.44080390
137PRKCI0.42965236
138LCK0.42869979
139LATS20.42375832
140BRSK20.41545859
141IRAK10.41376429
142PTK60.41200390
143MAP4K10.40807475
144SYK0.40629490
145JAK20.40590557
146PRPF4B0.40443101
147STK240.39085846
148BMPR20.37981245
149TAOK20.37233234
150ZAK0.36341596
151RPS6KA30.35728013
152MAP3K140.35094902
153PLK20.35027908

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86876948
2mRNA surveillance pathway_Homo sapiens_hsa030151.84775328
3Non-homologous end-joining_Homo sapiens_hsa034501.78771516
4Cell cycle_Homo sapiens_hsa041101.76313229
5RNA transport_Homo sapiens_hsa030131.62020340
6Basal cell carcinoma_Homo sapiens_hsa052171.50466614
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48095089
8Spliceosome_Homo sapiens_hsa030401.45081072
9Fanconi anemia pathway_Homo sapiens_hsa034601.44871946
10Adherens junction_Homo sapiens_hsa045201.44780775
11Renal cell carcinoma_Homo sapiens_hsa052111.43261637
12Mismatch repair_Homo sapiens_hsa034301.42851769
13Platelet activation_Homo sapiens_hsa046111.41175475
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40469553
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38637940
16Lysine degradation_Homo sapiens_hsa003101.37543802
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35957181
18MicroRNAs in cancer_Homo sapiens_hsa052061.32741376
19B cell receptor signaling pathway_Homo sapiens_hsa046621.28028708
20Wnt signaling pathway_Homo sapiens_hsa043101.25929009
21Long-term potentiation_Homo sapiens_hsa047201.23781962
22Oocyte meiosis_Homo sapiens_hsa041141.23489631
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23465681
24Insulin resistance_Homo sapiens_hsa049311.22326658
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.22192355
26Hedgehog signaling pathway_Homo sapiens_hsa043401.21488496
27mTOR signaling pathway_Homo sapiens_hsa041501.20110895
28Homologous recombination_Homo sapiens_hsa034401.19530422
29DNA replication_Homo sapiens_hsa030301.19265582
30Notch signaling pathway_Homo sapiens_hsa043301.18164392
31Colorectal cancer_Homo sapiens_hsa052101.18096816
32Hippo signaling pathway_Homo sapiens_hsa043901.18052334
33Prolactin signaling pathway_Homo sapiens_hsa049171.17257505
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17154804
35Endometrial cancer_Homo sapiens_hsa052131.14181914
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13725231
37Chronic myeloid leukemia_Homo sapiens_hsa052201.12968528
38RNA degradation_Homo sapiens_hsa030181.10881098
39Primary immunodeficiency_Homo sapiens_hsa053401.09045830
40Measles_Homo sapiens_hsa051621.07869749
41Fatty acid biosynthesis_Homo sapiens_hsa000611.05957835
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05823379
43Base excision repair_Homo sapiens_hsa034101.05738613
44Phototransduction_Homo sapiens_hsa047441.03035058
45Nicotine addiction_Homo sapiens_hsa050331.02522043
46ABC transporters_Homo sapiens_hsa020101.02170786
47Thyroid cancer_Homo sapiens_hsa052161.01446058
48HTLV-I infection_Homo sapiens_hsa051661.00836872
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00473582
50Type II diabetes mellitus_Homo sapiens_hsa049300.99758197
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98496129
52Prostate cancer_Homo sapiens_hsa052150.98293192
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97766149
54Insulin secretion_Homo sapiens_hsa049110.96240666
55Dorso-ventral axis formation_Homo sapiens_hsa043200.95932264
56Melanogenesis_Homo sapiens_hsa049160.95874824
57Amphetamine addiction_Homo sapiens_hsa050310.94562050
58Hepatitis B_Homo sapiens_hsa051610.94393114
59Basal transcription factors_Homo sapiens_hsa030220.94272151
60Glioma_Homo sapiens_hsa052140.92326962
61Systemic lupus erythematosus_Homo sapiens_hsa053220.92195669
62Acute myeloid leukemia_Homo sapiens_hsa052210.91037448
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90883080
64TGF-beta signaling pathway_Homo sapiens_hsa043500.90469868
65Pathways in cancer_Homo sapiens_hsa052000.89317280
66Selenocompound metabolism_Homo sapiens_hsa004500.89050172
67ErbB signaling pathway_Homo sapiens_hsa040120.87848480
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87091269
69T cell receptor signaling pathway_Homo sapiens_hsa046600.86946883
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86497694
71Non-small cell lung cancer_Homo sapiens_hsa052230.85007651
72Estrogen signaling pathway_Homo sapiens_hsa049150.84991057
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84256723
74Nucleotide excision repair_Homo sapiens_hsa034200.83500373
75Circadian entrainment_Homo sapiens_hsa047130.82452374
76Inositol phosphate metabolism_Homo sapiens_hsa005620.81407478
77Proteoglycans in cancer_Homo sapiens_hsa052050.80835819
78Small cell lung cancer_Homo sapiens_hsa052220.79998674
79Dilated cardiomyopathy_Homo sapiens_hsa054140.79796322
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.78717728
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78334356
82Dopaminergic synapse_Homo sapiens_hsa047280.78175046
83cAMP signaling pathway_Homo sapiens_hsa040240.77966735
84Renin secretion_Homo sapiens_hsa049240.77793651
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77646721
86Alcoholism_Homo sapiens_hsa050340.77440810
87MAPK signaling pathway_Homo sapiens_hsa040100.77124067
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76967743
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76185380
90FoxO signaling pathway_Homo sapiens_hsa040680.75633728
91Oxytocin signaling pathway_Homo sapiens_hsa049210.75402022
92Morphine addiction_Homo sapiens_hsa050320.74666713
93Rap1 signaling pathway_Homo sapiens_hsa040150.74356809
94Olfactory transduction_Homo sapiens_hsa047400.73979476
95Long-term depression_Homo sapiens_hsa047300.73399707
96p53 signaling pathway_Homo sapiens_hsa041150.73089696
97Viral carcinogenesis_Homo sapiens_hsa052030.71421765
98Melanoma_Homo sapiens_hsa052180.71046710
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68885851
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68397940
101Glucagon signaling pathway_Homo sapiens_hsa049220.67994884
102Osteoclast differentiation_Homo sapiens_hsa043800.67458781
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67259068
104Herpes simplex infection_Homo sapiens_hsa051680.66440821
105Pancreatic cancer_Homo sapiens_hsa052120.65766434
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.65692442
107Circadian rhythm_Homo sapiens_hsa047100.65574635
108Gap junction_Homo sapiens_hsa045400.64992090
109Focal adhesion_Homo sapiens_hsa045100.64775859
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64738832
111Antigen processing and presentation_Homo sapiens_hsa046120.64732442
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64429256
113HIF-1 signaling pathway_Homo sapiens_hsa040660.63805528
114Cocaine addiction_Homo sapiens_hsa050300.63749243
115Glutamatergic synapse_Homo sapiens_hsa047240.63258904
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.63238396
117Calcium signaling pathway_Homo sapiens_hsa040200.62918986
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62858768
119Epstein-Barr virus infection_Homo sapiens_hsa051690.62746997
120Tight junction_Homo sapiens_hsa045300.62576864
121Complement and coagulation cascades_Homo sapiens_hsa046100.61888593
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61356854
123Choline metabolism in cancer_Homo sapiens_hsa052310.61171559
124AMPK signaling pathway_Homo sapiens_hsa041520.60804715
125Insulin signaling pathway_Homo sapiens_hsa049100.60085427
126GnRH signaling pathway_Homo sapiens_hsa049120.56980827
127Propanoate metabolism_Homo sapiens_hsa006400.56837439
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.56565696
129Cholinergic synapse_Homo sapiens_hsa047250.54003656
130Toxoplasmosis_Homo sapiens_hsa051450.49555547
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.49515779
132Hepatitis C_Homo sapiens_hsa051600.49278714
133Influenza A_Homo sapiens_hsa051640.49248988
134TNF signaling pathway_Homo sapiens_hsa046680.48037332
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.47887754
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.47339126
137Taste transduction_Homo sapiens_hsa047420.45504783
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44335736
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43271976
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43046734
141Chemokine signaling pathway_Homo sapiens_hsa040620.42003063
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41157042

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