HELZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.16913126
2antigen processing and presentation of endogenous antigen (GO:0019883)5.94394665
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.89307864
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.89307864
5regulation of gamma-delta T cell activation (GO:0046643)4.77160386
6NIK/NF-kappaB signaling (GO:0038061)4.63209058
7regulation of gamma-delta T cell differentiation (GO:0045586)4.46271497
8cellular response to interferon-alpha (GO:0035457)4.31873333
9positive regulation of interferon-alpha production (GO:0032727)4.29613419
10response to type I interferon (GO:0034340)4.17470330
11negative regulation of viral genome replication (GO:0045071)4.12920011
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.12477205
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11073292
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11073292
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.11073292
16modulation by symbiont of host immune response (GO:0052553)4.11073292
17positive regulation by symbiont of host defense response (GO:0052509)4.11073292
18modulation by symbiont of host defense response (GO:0052031)4.11073292
19cellular response to type I interferon (GO:0071357)4.10465178
20type I interferon signaling pathway (GO:0060337)4.10465178
21regulation of interferon-alpha production (GO:0032647)4.08909678
22positive regulation of humoral immune response (GO:0002922)3.92472346
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.73731847
24detection of other organism (GO:0098543)3.68230768
25regulation of interferon-beta biosynthetic process (GO:0045357)3.67893019
26positive regulation of B cell differentiation (GO:0045579)3.64279339
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.61526321
28positive thymic T cell selection (GO:0045059)3.59598076
29detection of bacterium (GO:0016045)3.55898052
30response to muramyl dipeptide (GO:0032495)3.55481313
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48938500
32negative regulation of cytokine production involved in immune response (GO:0002719)3.44022916
33regulation of vitamin D biosynthetic process (GO:0060556)3.43851903
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41249334
35I-kappaB phosphorylation (GO:0007252)3.40495272
36JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.39511994
37interferon-gamma-mediated signaling pathway (GO:0060333)3.33808766
38B cell receptor signaling pathway (GO:0050853)3.28739762
39macrophage activation involved in immune response (GO:0002281)3.27940039
40leukocyte aggregation (GO:0070486)3.27726748
41positive regulation of antigen processing and presentation (GO:0002579)3.25299530
42interferon-gamma secretion (GO:0072643)3.25020554
43regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23592881
44regulation of alpha-beta T cell proliferation (GO:0046640)3.23305936
45cellular response to virus (GO:0098586)3.20800448
46regulation of type 2 immune response (GO:0002828)3.18049075
47regulation of B cell differentiation (GO:0045577)3.17439559
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15881136
49mature B cell differentiation (GO:0002335)3.13861155
50negative regulation of T cell mediated immunity (GO:0002710)3.13547610
51positive regulation of interferon-beta production (GO:0032728)3.13077360
52response to protozoan (GO:0001562)3.09921539
53detection of external biotic stimulus (GO:0098581)3.09852587
54response to peptidoglycan (GO:0032494)3.09180257
55regulation of T-helper 2 cell differentiation (GO:0045628)3.08134579
56cellular response to exogenous dsRNA (GO:0071360)3.07728487
57detection of molecule of bacterial origin (GO:0032490)3.05898569
58negative thymic T cell selection (GO:0045060)3.05368599
59myeloid dendritic cell differentiation (GO:0043011)2.98081308
60positive regulation of interleukin-12 production (GO:0032735)2.97064200
61regulation of B cell receptor signaling pathway (GO:0050855)2.96121867
62response to interferon-beta (GO:0035456)2.95862906
63germinal center formation (GO:0002467)2.95808829
64immunoglobulin mediated immune response (GO:0016064)2.92846745
65regulation of cytokine secretion involved in immune response (GO:0002739)2.92802817
66negative regulation of cell killing (GO:0031342)2.92212247
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92212247
68natural killer cell mediated cytotoxicity (GO:0042267)2.91775944
69natural killer cell mediated immunity (GO:0002228)2.91775944
70defense response to virus (GO:0051607)2.91615305
71T cell migration (GO:0072678)2.91512331
72regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91286734
73negative regulation of viral process (GO:0048525)2.90660949
74regulation of T cell tolerance induction (GO:0002664)2.90244259
75negative T cell selection (GO:0043383)2.89501856
76regulation of cholesterol storage (GO:0010885)2.87948494
77negative regulation of type 2 immune response (GO:0002829)2.87739312
78regulation of chronic inflammatory response (GO:0002676)2.84653678
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84468361
80response to host immune response (GO:0052572)2.84468361
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.83727516
82response to interferon-alpha (GO:0035455)2.83717132
83positive regulation of interleukin-2 production (GO:0032743)2.83237496
84positive regulation of chemokine biosynthetic process (GO:0045080)2.82106429
85negative regulation of erythrocyte differentiation (GO:0045647)2.81774075
86positive regulation of natural killer cell differentiation (GO:0032825)2.81324179
87thymic T cell selection (GO:0045061)2.80252672
88negative regulation of interleukin-12 production (GO:0032695)2.79436622
89positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.79312391
90T-helper 1 type immune response (GO:0042088)2.79214467
91positive regulation of cellular amide metabolic process (GO:0034250)2.78900980
92regulation of podosome assembly (GO:0071801)2.78286774
93regulation of viral genome replication (GO:0045069)2.78166106
94phospholipid homeostasis (GO:0055091)2.77740549
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77722147
96regulation of chemokine biosynthetic process (GO:0045073)2.75875654
97negative regulation of lymphocyte mediated immunity (GO:0002707)2.75474476
98defense response to protozoan (GO:0042832)2.73836851
99positive regulation of T cell cytokine production (GO:0002726)2.73640926
100negative regulation of innate immune response (GO:0045824)2.72530234
101regulation of MHC class I biosynthetic process (GO:0045343)2.72044997
102modulation by symbiont of host cellular process (GO:0044068)2.71964877
103detection of biotic stimulus (GO:0009595)2.71513403
104regulation of T-helper 1 cell differentiation (GO:0045625)2.70776124
105regulation of antigen processing and presentation (GO:0002577)2.70155336
106regulation of interleukin-12 production (GO:0032655)2.69983831
107granulocyte activation (GO:0036230)2.69489228
108regulation of vitamin metabolic process (GO:0030656)2.69265813
109T cell selection (GO:0045058)2.69040132
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69018083
111negative regulation of viral release from host cell (GO:1902187)2.68535731
112negative regulation of production of molecular mediator of immune response (GO:0002701)2.68397166
113negative regulation of type I interferon production (GO:0032480)2.68098794
114response to interferon-gamma (GO:0034341)2.66520738
115lymphocyte chemotaxis (GO:0048247)2.66291610
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.64341032
117macrophage activation (GO:0042116)2.64312745
118response to host (GO:0075136)2.62901706
119response to host defenses (GO:0052200)2.62901706
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62901706
121positive regulation of transcription factor import into nucleus (GO:0042993)2.61092557
122urea cycle (GO:0000050)2.60423388
123urea metabolic process (GO:0019627)2.60423388
124myeloid dendritic cell activation (GO:0001773)2.60400806
125low-density lipoprotein particle clearance (GO:0034383)2.60304860
126positive T cell selection (GO:0043368)2.60027760
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58529468
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58502706
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56167457
130neutrophil activation involved in immune response (GO:0002283)2.54391334
131regulation of RIG-I signaling pathway (GO:0039535)2.54315634
132regulation of response to interferon-gamma (GO:0060330)2.54084908
133cytokine secretion (GO:0050663)2.54031875
134phospholipid efflux (GO:0033700)2.53987298
135cellular response to interferon-gamma (GO:0071346)2.52667068
136plasma lipoprotein particle clearance (GO:0034381)2.51533202
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.50903560
138regulation of superoxide anion generation (GO:0032928)2.50698691
139complement activation, alternative pathway (GO:0006957)2.48209400
140positive regulation of type 2 immune response (GO:0002830)2.48116423
141positive regulation of toll-like receptor signaling pathway (GO:0034123)2.47567376
142negative regulation of sterol transport (GO:0032372)2.46622449
143negative regulation of cholesterol transport (GO:0032375)2.46622449
144positive regulation of cytokine biosynthetic process (GO:0042108)2.45774911
145regulation of interferon-beta production (GO:0032648)2.45610586
146negative regulation of lipid storage (GO:0010888)2.44878218
147regulation of humoral immune response (GO:0002920)2.44868023
148positive regulation of lipid storage (GO:0010884)2.43672794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.60248940
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.65391213
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.35679918
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15375377
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89045847
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.85569905
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69708136
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.19382343
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99258283
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98888555
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.97486720
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80171329
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78604499
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.66513563
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62456530
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.52525047
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51600012
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.51217547
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35409267
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34846781
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23212016
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21960785
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19754309
24MAF_26560356_Chip-Seq_TH1_Human2.16943991
25GATA1_22025678_ChIP-Seq_K562_Human2.14241598
26MYC_22102868_ChIP-Seq_BL_Human2.13916152
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11687469
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09974293
29RUNX_20019798_ChIP-Seq_JUKART_Human2.09236873
30VDR_21846776_ChIP-Seq_THP-1_Human2.06255684
31MYB_26560356_Chip-Seq_TH1_Human1.94649928
32MYB_26560356_Chip-Seq_TH2_Human1.86607922
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.85350677
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84637738
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83191198
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79726119
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.77166500
38SCL_19346495_ChIP-Seq_HPC-7_Human1.76045404
39VDR_24763502_ChIP-Seq_THP-1_Human1.70593287
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68767824
41TCF7_22412390_ChIP-Seq_EML_Mouse1.67781404
42UTX_26944678_Chip-Seq_JUKART_Human1.65286365
43RACK7_27058665_Chip-Seq_MCF-7_Human1.64122640
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63047388
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61849313
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60617881
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59396018
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57099054
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55488586
50SPI1_23127762_ChIP-Seq_K562_Human1.51790715
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51465346
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50877314
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50476065
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47176162
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44150237
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.41784441
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.41644544
58SPI1_23547873_ChIP-Seq_NB4_Human1.39202337
59KDM2B_26808549_Chip-Seq_DND41_Human1.38341814
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36657068
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36040188
62PU_27001747_Chip-Seq_BMDM_Mouse1.35791163
63KDM2B_26808549_Chip-Seq_K562_Human1.30520981
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30298468
65MAF_26560356_Chip-Seq_TH2_Human1.30166767
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25362208
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24655781
68GATA3_27048872_Chip-Seq_THYMUS_Human1.24342497
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.21549795
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17244728
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.17031881
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15740565
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13203946
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13127443
75VDR_24787735_ChIP-Seq_THP-1_Human1.11322780
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10776869
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.10546573
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06289523
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05335079
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.04460238
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04395970
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04376013
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02359297
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02309543
85BCOR_27268052_Chip-Seq_Bcells_Human1.00446967
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00439143
87GATA3_26560356_Chip-Seq_TH2_Human1.00303838
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98330933
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97756995
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97617880
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96609256
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95953735
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.95777776
94BCL6_27268052_Chip-Seq_Bcells_Human0.95682412
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95528288
96TP63_17297297_ChIP-ChIP_HaCaT_Human0.95125142
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.95067166
98SMC4_20622854_ChIP-Seq_HELA_Human0.94146049
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93499179
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91990814
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91585217
102GATA2_19941826_ChIP-Seq_K562_Human0.90663462
103LXR_22292898_ChIP-Seq_THP-1_Human0.89765082
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89507549
105GATA1_19941826_ChIP-Seq_K562_Human0.89335337
106FOXA2_19822575_ChIP-Seq_HepG2_Human0.89116626
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88614550
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87187020
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83801979
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83358627
111CLOCK_20551151_ChIP-Seq_293T_Human0.83050365
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82620991
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82106697
114NCOR1_26117541_ChIP-Seq_K562_Human0.80931764
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80801386
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79066512
117GATA6_25053715_ChIP-Seq_YYC3_Human0.78164407
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77040390
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.76539499
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.75981891
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75689041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.87039589
2MP0001790_abnormal_immune_system3.35869345
3MP0005387_immune_system_phenotype3.35869345
4MP0000685_abnormal_immune_system3.19233739
5MP0003303_peritoneal_inflammation3.04219275
6MP0001800_abnormal_humoral_immune3.03734714
7MP0005360_urolithiasis3.00783354
8MP0002139_abnormal_hepatobiliary_system2.83714916
9MP0003436_decreased_susceptibility_to2.68040825
10MP0009785_altered_susceptibility_to2.63549258
11MP0005000_abnormal_immune_tolerance2.52821836
12MP0002452_abnormal_antigen_presenting2.49688616
13MP0004510_myositis2.46356328
14MP0002723_abnormal_immune_serum2.37780984
15MP0005025_abnormal_response_to2.32853884
16MP0009840_abnormal_foam_cell2.22304218
17MP0005671_abnormal_response_to2.22255596
18MP0002419_abnormal_innate_immunity2.20592130
19MP0003300_gastrointestinal_ulcer2.17569334
20MP0004947_skin_inflammation2.11072942
21MP0000569_abnormal_digit_pigmentation2.10908554
22MP0002420_abnormal_adaptive_immunity2.06422899
23MP0001819_abnormal_immune_cell2.06294423
24MP0002138_abnormal_hepatobiliary_system2.03487070
25MP0005365_abnormal_bile_salt2.03187525
26MP0002166_altered_tumor_susceptibility1.93965580
27MP0005085_abnormal_gallbladder_physiolo1.90079233
28MP0002148_abnormal_hypersensitivity_rea1.89142382
29MP0009278_abnormal_bone_marrow1.80957960
30MP0002398_abnormal_bone_marrow1.76733237
31MP0005464_abnormal_platelet_physiology1.75192943
32MP0003724_increased_susceptibility_to1.73231561
33MP0010155_abnormal_intestine_physiology1.72987159
34MP0003252_abnormal_bile_duct1.72149247
35MP0005083_abnormal_biliary_tract1.72061623
36MP0000716_abnormal_immune_system1.71047014
37MP0003191_abnormal_cellular_cholesterol1.69562324
38MP0003763_abnormal_thymus_physiology1.68052653
39MP0001845_abnormal_inflammatory_respons1.66608448
40MP0006082_CNS_inflammation1.66298059
41MP0001853_heart_inflammation1.61746625
42MP0008469_abnormal_protein_level1.60795634
43MP0002405_respiratory_system_inflammati1.58731630
44MP0000689_abnormal_spleen_morphology1.57097048
45MP0001873_stomach_inflammation1.55846081
46MP0008004_abnormal_stomach_pH1.55085956
47MP0002006_tumorigenesis1.51367648
48MP0008875_abnormal_xenobiotic_pharmacok1.46468644
49MP0000609_abnormal_liver_physiology1.44744835
50MP0009764_decreased_sensitivity_to1.44135600
51MP0002332_abnormal_exercise_endurance1.44038109
52MP0002429_abnormal_blood_cell1.38239063
53MP0005058_abnormal_lysosome_morphology1.36621017
54MP0002722_abnormal_immune_system1.36011881
55MP0002254_reproductive_system_inflammat1.35817307
56MP0001545_abnormal_hematopoietic_system1.34634116
57MP0005397_hematopoietic_system_phenotyp1.34634116
58MP0010329_abnormal_lipoprotein_level1.31269953
59MP0000604_amyloidosis1.28856798
60MP0001533_abnormal_skeleton_physiology1.26198306
61MP0003172_abnormal_lysosome_physiology1.23179190
62MP0003183_abnormal_peptide_metabolism1.22003606
63MP0009763_increased_sensitivity_to1.18635244
64MP0000343_altered_response_to1.17962585
65MP0003091_abnormal_cell_migration1.13927091
66MP0004808_abnormal_hematopoietic_stem1.10543450
67MP0001666_abnormal_nutrient_absorption1.05577768
68MP0003705_abnormal_hypodermis_morpholog1.05569714
69MP0005164_abnormal_response_to1.04927827
70MP0009333_abnormal_splenocyte_physiolog1.03576037
71MP0005390_skeleton_phenotype1.02372809
72MP0003448_altered_tumor_morphology1.02126892
73MP0005076_abnormal_cell_differentiation0.99476419
74MP0004381_abnormal_hair_follicle0.98710609
75MP0003566_abnormal_cell_adhesion0.98586705
76MP0005310_abnormal_salivary_gland0.98430874
77MP0003690_abnormal_glial_cell0.97640892
78MP0002396_abnormal_hematopoietic_system0.97167703
79MP0003453_abnormal_keratinocyte_physiol0.94670752
80MP0003866_abnormal_defecation0.94070644
81MP0000703_abnormal_thymus_morphology0.93356895
82MP0004883_abnormal_blood_vessel0.92992179
83MP0010352_gastrointestinal_tract_polyps0.92360623
84MP0005319_abnormal_enzyme/_coenzyme0.91256342
85MP0002933_joint_inflammation0.91004932
86MP0001851_eye_inflammation0.90633874
87MP0002877_abnormal_melanocyte_morpholog0.87848016
88MP0002136_abnormal_kidney_physiology0.87311895
89MP0000598_abnormal_liver_morphology0.87304423
90MP0001663_abnormal_digestive_system0.87238095
91MP0005023_abnormal_wound_healing0.87201815
92MP0003828_pulmonary_edema0.86219928
93MP0002928_abnormal_bile_duct0.84465568
94MP0001849_ear_inflammation0.84202496
95MP0002998_abnormal_bone_remodeling0.84137838
96MP0008260_abnormal_autophagy0.83679600
97MP0000465_gastrointestinal_hemorrhage0.83636653
98MP0003656_abnormal_erythrocyte_physiolo0.83102408
99MP0004858_abnormal_nervous_system0.83029609
100MP0010307_abnormal_tumor_latency0.82498933
101MP0005174_abnormal_tail_pigmentation0.82153189
102MP0002118_abnormal_lipid_homeostasis0.81403037
103MP0009765_abnormal_xenobiotic_induced0.81107100
104MP0000249_abnormal_blood_vessel0.79550103
105MP0000371_diluted_coat_color0.77682421
106MP0005584_abnormal_enzyme/coenzyme_acti0.77286695
107MP0000767_abnormal_smooth_muscle0.74372063
108MP0009643_abnormal_urine_homeostasis0.74230508
109MP0005166_decreased_susceptibility_to0.73550046
110MP0001348_abnormal_lacrimal_gland0.73072796
111MP0005332_abnormal_amino_acid0.72980785
112MP0005666_abnormal_adipose_tissue0.72779580
113MP0003045_fibrosis0.72226636
114MP0000858_altered_metastatic_potential0.72061224
115MP0008874_decreased_physiological_sensi0.70791714
116MP0005167_abnormal_blood-brain_barrier0.69763082
117MP0008961_abnormal_basal_metabolism0.69706629
118MP0010234_abnormal_vibrissa_follicle0.68951423
119MP0003075_altered_response_to0.66057341
120MP0006054_spinal_hemorrhage0.66032381
121MP0001216_abnormal_epidermal_layer0.65569363
122MP0003795_abnormal_bone_structure0.65540152
123MP0004185_abnormal_adipocyte_glucose0.65379441
124MP0002796_impaired_skin_barrier0.65261286
125MP0005451_abnormal_body_composition0.62425498

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)4.06604158
2Autoimmune thrombocytopenia (HP:0001973)4.01729340
3Eczematoid dermatitis (HP:0000976)3.98677413
4Recurrent bacterial skin infections (HP:0005406)3.97173883
5Chronic otitis media (HP:0000389)3.93040607
6Colitis (HP:0002583)3.83167351
7Recurrent abscess formation (HP:0002722)3.82718325
8Elevated erythrocyte sedimentation rate (HP:0003565)3.81346473
9Vasculitis (HP:0002633)3.75267648
10Agammaglobulinemia (HP:0004432)3.69210401
11Recurrent gram-negative bacterial infections (HP:0005420)3.63183547
12Recurrent bronchitis (HP:0002837)3.62179004
13Recurrent fungal infections (HP:0002841)3.57549021
14Myocardial infarction (HP:0001658)3.52712517
15Gastrointestinal stroma tumor (HP:0100723)3.52522276
16Abnormality of liposaccharide metabolism (HP:0010968)3.35470839
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.35470839
18Abnormality of glycolipid metabolism (HP:0010969)3.35470839
19Mediastinal lymphadenopathy (HP:0100721)3.33822771
20Gingival bleeding (HP:0000225)3.23736914
21Inflammation of the large intestine (HP:0002037)3.20924425
22Myositis (HP:0100614)3.20843342
23Recurrent skin infections (HP:0001581)3.16957169
24Stomatitis (HP:0010280)3.16309826
25Loss of speech (HP:0002371)3.13418418
26Deep venous thrombosis (HP:0002625)3.13327376
27Mitral stenosis (HP:0001718)3.11322173
28Nasal polyposis (HP:0100582)3.09730678
29Gastrointestinal inflammation (HP:0004386)3.05156726
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.03795012
31Chronic mucocutaneous candidiasis (HP:0002728)2.99971805
32Recurrent cutaneous fungal infections (HP:0011370)2.99971805
33Orchitis (HP:0100796)2.98844274
34Cellulitis (HP:0100658)2.98608714
35Pustule (HP:0200039)2.93802517
36Retrobulbar optic neuritis (HP:0100654)2.91259680
37Optic neuritis (HP:0100653)2.91259680
38Emphysema (HP:0002097)2.90878895
39Joint hemorrhage (HP:0005261)2.90018264
40Abnormality of the nasal mucosa (HP:0000433)2.86192586
41Periodontitis (HP:0000704)2.86014848
42Abnormality of the fingertips (HP:0001211)2.83760457
43Dysostosis multiplex (HP:0000943)2.79218266
44Xanthomatosis (HP:0000991)2.73198703
45Meningitis (HP:0001287)2.71630783
46Pulmonary infiltrates (HP:0002113)2.70965179
47Abnormality of macrophages (HP:0004311)2.68663329
48Arterial thrombosis (HP:0004420)2.65895583
49Hematochezia (HP:0002573)2.65129903
50Chronic obstructive pulmonary disease (HP:0006510)2.61877336
51Obstructive lung disease (HP:0006536)2.61877336
52Panhypogammaglobulinemia (HP:0003139)2.57959890
53Increased IgM level (HP:0003496)2.57648634
54Complement deficiency (HP:0004431)2.56148075
55Recurrent sinusitis (HP:0011108)2.54747204
56Intrahepatic cholestasis (HP:0001406)2.53934392
57Increased cerebral lipofuscin (HP:0011813)2.53621963
58Osteomyelitis (HP:0002754)2.52311569
59Gingivitis (HP:0000230)2.50243148
60Abnormality of T cell number (HP:0011839)2.48374479
61Increased IgE level (HP:0003212)2.46146445
62Spontaneous hematomas (HP:0007420)2.46031297
63Amyloidosis (HP:0011034)2.45064076
64T lymphocytopenia (HP:0005403)2.44333566
65Lymphopenia (HP:0001888)2.43772157
66Abnormality of the common coagulation pathway (HP:0010990)2.43409956
67Gangrene (HP:0100758)2.43027678
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41349823
69IgA deficiency (HP:0002720)2.38808593
70Restrictive lung disease (HP:0002091)2.38711658
71Prolonged partial thromboplastin time (HP:0003645)2.37742644
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.37411769
73Chronic sinusitis (HP:0011109)2.37229431
74IgM deficiency (HP:0002850)2.35225791
75Abnormality of polysaccharide metabolism (HP:0011012)2.32873807
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32873807
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32873807
78Gastrointestinal infarctions (HP:0005244)2.31366552
79Chronic diarrhea (HP:0002028)2.30279299
80Joint swelling (HP:0001386)2.28903588
81Epistaxis (HP:0000421)2.28038865
82Peritonitis (HP:0002586)2.26769829
83Interstitial pulmonary disease (HP:0006530)2.26166781
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25917233
85Mucopolysacchariduria (HP:0008155)2.25698326
86Urinary glycosaminoglycan excretion (HP:0003541)2.25698326
87Esophageal varix (HP:0002040)2.24872906
88Papilloma (HP:0012740)2.24612686
89Verrucae (HP:0200043)2.24612686
90Systemic lupus erythematosus (HP:0002725)2.24116197
91Thin bony cortex (HP:0002753)2.23552160
92Hypobetalipoproteinemia (HP:0003563)2.23539068
93Anorexia (HP:0002039)2.23273380
94Increased serum ferritin (HP:0003281)2.22169151
95Abnormality of the pericardium (HP:0001697)2.19005253
96Leukocytosis (HP:0001974)2.15599338
97Vacuolated lymphocytes (HP:0001922)2.14777283
98Abnormality of T cells (HP:0002843)2.14392793
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13940499
100Thrombophlebitis (HP:0004418)2.11700958
101Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11532296
102Abnormality of the pleura (HP:0002103)2.11519332
103Pulmonary embolism (HP:0002204)2.10668804
104Keratoconjunctivitis sicca (HP:0001097)2.09387504
105Abnormality of the endocardium (HP:0004306)2.07952223
106Hemoptysis (HP:0002105)2.07906887
107Hyperlipoproteinemia (HP:0010980)2.07865176
108Autoimmune hemolytic anemia (HP:0001890)2.06818854
109Malnutrition (HP:0004395)2.05520785
110Chest pain (HP:0100749)2.04650845
111Encephalitis (HP:0002383)2.03183517
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.03027808
113Osteolytic defects of the hand bones (HP:0009699)2.03027808
114Epidermoid cyst (HP:0200040)2.02288347
115Abnormality of complement system (HP:0005339)2.00651249
116Polycythemia (HP:0001901)2.00422887
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.99368045
118Abnormality of T cell physiology (HP:0011840)1.99348046
119Eosinophilia (HP:0001880)1.98708447
120Urticaria (HP:0001025)1.98555609
121Thick nail (HP:0001805)1.97448874
122Abnormal platelet volume (HP:0011876)1.94923347
123Broad face (HP:0000283)1.93584635
124Episodic fever (HP:0001954)1.93566433
125Arthralgia (HP:0002829)1.92639908
126Acne (HP:0001061)1.92593570
127Frequent falls (HP:0002359)1.92577190
128Hypercholesterolemia (HP:0003124)1.91681505
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.91592105
130Glomerulopathy (HP:0100820)1.89808430
131Premature loss of primary teeth (HP:0006323)1.89202067
132Hypergammaglobulinemia (HP:0010702)1.88907867
133Hemorrhage of the eye (HP:0011885)1.88586726
134Keratoconjunctivitis (HP:0001096)1.88486759
135Purpura (HP:0000979)1.86947552
136Sepsis (HP:0100806)1.86776732
137Polygenic inheritance (HP:0010982)1.85985478
138Segmental peripheral demyelination/remyelination (HP:0003481)1.85516014
139Keratitis (HP:0000491)1.81955750
140Cheilitis (HP:0100825)1.81709994
141Skin ulcer (HP:0200042)1.80489287
142Vertigo (HP:0002321)1.79009426
143Prolonged bleeding time (HP:0003010)1.78208331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.31653938
2TYK23.91620031
3MAP3K143.85261652
4IKBKE3.04748579
5ERN13.01491452
6PRPF4B2.96918172
7MAP3K132.91930150
8JAK32.87994363
9JAK12.85272199
10TBK12.82627686
11FGFR42.80240129
12IRAK32.54717670
13MAP3K102.35445656
14RIPK42.10695331
15BLK1.94818476
16IKBKB1.93154970
17KIT1.91882328
18IRAK41.80157422
19TAOK21.80010127
20SIK11.75393965
21CDK121.65592503
22EPHB11.65508922
23TAOK31.64594420
24GRK61.59016221
25SMG11.58985342
26MAP3K111.58838950
27SIK21.57612443
28FGFR31.56607295
29CHUK1.53613344
30CSF1R1.49051629
31SYK1.46015596
32CDC42BPA1.45926404
33STK101.45572386
34ZAP701.45124306
35CSK1.44069270
36TXK1.39057367
37PTK61.37332101
38BTK1.34004429
39GRK71.30399404
40HCK1.27524473
41TTN1.27153292
42TRIB31.24823463
43DDR21.22805157
44TNK21.21807154
45EPHA31.19851875
46JAK21.19537079
47MARK31.12784670
48LCK1.11666565
49NME21.11652163
50IRAK21.09883507
51EPHA21.08297956
52LRRK21.05033941
53ITK1.04145796
54ICK1.01521759
55TGFBR20.98873783
56CAMK1D0.94556895
57PKN20.93396584
58PIM10.91603608
59MARK20.91140873
60PRKD20.91043751
61MAP3K70.84873616
62RPS6KA40.84695791
63FES0.82485147
64BMPR20.82048084
65LYN0.80879276
66CAMK1G0.80754972
67MAP2K30.77718432
68PRKCQ0.75212743
69SIK30.74370067
70RIPK10.69742606
71MOS0.68683067
72TEC0.68638683
73NEK90.66754960
74EEF2K0.66374078
75PIM20.63783741
76EGFR0.60825884
77MAP3K60.60251427
78MST1R0.59840833
79FGR0.59161719
80PDGFRA0.58932918
81NLK0.57890633
82MAPK110.55850171
83RPS6KA20.54284850
84RPS6KL10.53857056
85RPS6KC10.53857056
86ABL10.53111176
87CDK60.52345007
88FLT30.52325803
89KDR0.52202501
90KSR20.51576327
91SGK30.50481866
92TESK20.49694651
93TYRO30.49179776
94PRKCH0.48381063
95BRD40.46037073
96DAPK20.46022326
97PDK10.45332672
98PRKAA20.44796116
99PAK40.44581492
100MTOR0.44479774
101CDK40.43023028
102PDGFRB0.42904763
103MAP3K30.42663131
104IRAK10.42597483
105STK40.42566565
106RPS6KA60.42530761
107BMX0.41598401
108HIPK20.41514010
109MAP2K60.41211762
110MAP3K50.40731011
111PKN10.40522823
112MAPKAPK20.37578364
113ALK0.36544743
114STK30.34047521
115PDPK10.33288833
116CLK10.33277321
117INSR0.31986782
118MST40.31973301
119MAPK70.31924158
120MAP2K20.29061674
121MAPK40.27903092
122FYN0.27617168
123MELK0.27346080
124TRPM70.26593780
125MATK0.26296045
126MAPK120.26219253
127PRKCD0.21362264
128MAP3K10.21313424
129DYRK1B0.20656773
130TAOK10.20305088
131GSK3A0.19252846
132MAPK30.19243546

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86557878
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.71801379
3B cell receptor signaling pathway_Homo sapiens_hsa046622.68602827
4Primary immunodeficiency_Homo sapiens_hsa053402.59000146
5Staphylococcus aureus infection_Homo sapiens_hsa051502.46185267
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.30527795
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.28996710
8Leishmaniasis_Homo sapiens_hsa051402.24067855
9Caffeine metabolism_Homo sapiens_hsa002322.23865856
10Measles_Homo sapiens_hsa051622.17664119
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09960714
12Osteoclast differentiation_Homo sapiens_hsa043802.08729454
13Other glycan degradation_Homo sapiens_hsa005112.00578293
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.92716079
15Complement and coagulation cascades_Homo sapiens_hsa046101.89843180
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89587454
17Influenza A_Homo sapiens_hsa051641.82943275
18Allograft rejection_Homo sapiens_hsa053301.69725369
19Arginine biosynthesis_Homo sapiens_hsa002201.61778334
20TNF signaling pathway_Homo sapiens_hsa046681.60584894
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55321508
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53220892
23Herpes simplex infection_Homo sapiens_hsa051681.52324676
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52165539
25Nitrogen metabolism_Homo sapiens_hsa009101.52057362
26Toxoplasmosis_Homo sapiens_hsa051451.44925005
27Hematopoietic cell lineage_Homo sapiens_hsa046401.44808582
28Malaria_Homo sapiens_hsa051441.40636581
29Hepatitis C_Homo sapiens_hsa051601.40311572
30T cell receptor signaling pathway_Homo sapiens_hsa046601.38521918
31Graft-versus-host disease_Homo sapiens_hsa053321.37973542
32Tryptophan metabolism_Homo sapiens_hsa003801.36289713
33Tuberculosis_Homo sapiens_hsa051521.33309221
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.31207324
35Pertussis_Homo sapiens_hsa051331.28055032
36ABC transporters_Homo sapiens_hsa020101.27162721
37Lysine degradation_Homo sapiens_hsa003101.19491088
38Antigen processing and presentation_Homo sapiens_hsa046121.18568808
39African trypanosomiasis_Homo sapiens_hsa051431.14350247
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14020671
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13751543
42Legionellosis_Homo sapiens_hsa051341.13422593
43Apoptosis_Homo sapiens_hsa042101.12802204
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.12135212
45Hepatitis B_Homo sapiens_hsa051611.11807545
46VEGF signaling pathway_Homo sapiens_hsa043701.09699566
47Lysosome_Homo sapiens_hsa041421.09409428
48Acute myeloid leukemia_Homo sapiens_hsa052211.08111363
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.05276399
50Chemokine signaling pathway_Homo sapiens_hsa040621.03854284
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01749964
52PPAR signaling pathway_Homo sapiens_hsa033200.99600793
53Insulin resistance_Homo sapiens_hsa049310.98487755
54Viral myocarditis_Homo sapiens_hsa054160.95048326
55Bladder cancer_Homo sapiens_hsa052190.94790151
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93155941
57Fatty acid degradation_Homo sapiens_hsa000710.93115645
58Chronic myeloid leukemia_Homo sapiens_hsa052200.89998527
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89222927
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85668635
61Phagosome_Homo sapiens_hsa041450.85161691
62Prolactin signaling pathway_Homo sapiens_hsa049170.84032975
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81698494
64Shigellosis_Homo sapiens_hsa051310.81203352
65Non-small cell lung cancer_Homo sapiens_hsa052230.80646174
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80071246
67Prion diseases_Homo sapiens_hsa050200.79544152
68Small cell lung cancer_Homo sapiens_hsa052220.77013777
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.76696658
70Type II diabetes mellitus_Homo sapiens_hsa049300.72813030
71Renal cell carcinoma_Homo sapiens_hsa052110.69837280
72Pancreatic cancer_Homo sapiens_hsa052120.69456862
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68871867
74Selenocompound metabolism_Homo sapiens_hsa004500.66922771
75Histidine metabolism_Homo sapiens_hsa003400.66665454
76Peroxisome_Homo sapiens_hsa041460.65565476
77Asthma_Homo sapiens_hsa053100.63822073
78Phenylalanine metabolism_Homo sapiens_hsa003600.62913141
79Bile secretion_Homo sapiens_hsa049760.62317152
80HTLV-I infection_Homo sapiens_hsa051660.61510332
81Autoimmune thyroid disease_Homo sapiens_hsa053200.61148931
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.60864501
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59995979
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.59749928
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.56972343
86Fat digestion and absorption_Homo sapiens_hsa049750.56597101
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56222454
88mTOR signaling pathway_Homo sapiens_hsa041500.56212233
89FoxO signaling pathway_Homo sapiens_hsa040680.55541775
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55164218
91Endometrial cancer_Homo sapiens_hsa052130.54474363
92Endocytosis_Homo sapiens_hsa041440.53090260
93Starch and sucrose metabolism_Homo sapiens_hsa005000.52788884
94HIF-1 signaling pathway_Homo sapiens_hsa040660.51689717
95Type I diabetes mellitus_Homo sapiens_hsa049400.51040883
96Platelet activation_Homo sapiens_hsa046110.50772401
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50171824
98Rheumatoid arthritis_Homo sapiens_hsa053230.49765623
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.49363932
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48420335
101GnRH signaling pathway_Homo sapiens_hsa049120.47873256
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47752861
103Epstein-Barr virus infection_Homo sapiens_hsa051690.47628917
104Chemical carcinogenesis_Homo sapiens_hsa052040.47526188
105Salmonella infection_Homo sapiens_hsa051320.47517054
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47387558
107Amoebiasis_Homo sapiens_hsa051460.46811390
108ErbB signaling pathway_Homo sapiens_hsa040120.46664618
109beta-Alanine metabolism_Homo sapiens_hsa004100.45676397
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43972918
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43923235
112Insulin signaling pathway_Homo sapiens_hsa049100.43142345
113MAPK signaling pathway_Homo sapiens_hsa040100.42288453
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.42025597
115One carbon pool by folate_Homo sapiens_hsa006700.41919435
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41203759
117Viral carcinogenesis_Homo sapiens_hsa052030.41190619
118Prostate cancer_Homo sapiens_hsa052150.41056010
119Notch signaling pathway_Homo sapiens_hsa043300.40120656
120Proteoglycans in cancer_Homo sapiens_hsa052050.39971526
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39957791
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37647300
123Choline metabolism in cancer_Homo sapiens_hsa052310.37555629
124Fatty acid metabolism_Homo sapiens_hsa012120.36944478
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36221662
126Vitamin digestion and absorption_Homo sapiens_hsa049770.35662125
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34910743
128Dorso-ventral axis formation_Homo sapiens_hsa043200.34718885
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34604469
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34497535
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33771338
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.33346387
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32896274
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32313636
135Galactose metabolism_Homo sapiens_hsa000520.32100278

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »