HEMGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tetrapyrrole biosynthetic process (GO:0033014)9.81049330
2heme metabolic process (GO:0042168)9.05757931
3porphyrin-containing compound metabolic process (GO:0006778)8.65631530
4erythrocyte maturation (GO:0043249)8.00369934
5erythrocyte development (GO:0048821)6.15895119
6hemoglobin metabolic process (GO:0020027)5.74534932
7tetrapyrrole metabolic process (GO:0033013)5.63200509
8pigment biosynthetic process (GO:0046148)5.48381097
9negative regulation of erythrocyte differentiation (GO:0045647)5.36629859
10positive regulation of granulocyte differentiation (GO:0030854)5.07919754
11response to methylmercury (GO:0051597)5.07326746
12DNA replication initiation (GO:0006270)4.88527146
13telomere maintenance via semi-conservative replication (GO:0032201)4.81503475
14DNA strand elongation involved in DNA replication (GO:0006271)4.80806043
15DNA strand elongation (GO:0022616)4.73670299
16one-carbon compound transport (GO:0019755)4.69825017
17megakaryocyte development (GO:0035855)4.62530067
18positive regulation of gamma-delta T cell activation (GO:0046645)4.61311034
19pigment metabolic process (GO:0042440)4.56927737
20response to lead ion (GO:0010288)4.52459596
21response to insecticide (GO:0017085)4.45680679
22erythrocyte differentiation (GO:0030218)4.42790070
23DNA replication checkpoint (GO:0000076)4.41540183
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.37693753
25neutrophil activation involved in immune response (GO:0002283)4.30795678
26ribosomal small subunit assembly (GO:0000028)4.12108646
27telomere maintenance via recombination (GO:0000722)4.09586551
28protein localization to chromosome, centromeric region (GO:0071459)4.03965954
29myeloid cell development (GO:0061515)4.02889382
30DNA unwinding involved in DNA replication (GO:0006268)4.01588700
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92792805
32protein localization to kinetochore (GO:0034501)3.83110532
33mitotic recombination (GO:0006312)3.82459639
34CENP-A containing nucleosome assembly (GO:0034080)3.73492195
35hepatocyte apoptotic process (GO:0097284)3.73009200
36mitotic sister chromatid segregation (GO:0000070)3.71250489
37kinetochore organization (GO:0051383)3.68055282
38positive regulation of B cell differentiation (GO:0045579)3.66797681
39regulation of response to osmotic stress (GO:0047484)3.57857532
40chromatin remodeling at centromere (GO:0031055)3.53220640
41telomere maintenance via telomere lengthening (GO:0010833)3.52712830
42attachment of spindle microtubules to kinetochore (GO:0008608)3.50222080
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.46308227
44regulation of gamma-delta T cell differentiation (GO:0045586)3.41050937
45gas transport (GO:0015669)3.40173901
46embryonic hemopoiesis (GO:0035162)3.39343600
47meiotic chromosome segregation (GO:0045132)3.39304981
48sister chromatid segregation (GO:0000819)3.34571554
49DNA replication-independent nucleosome organization (GO:0034724)3.34404628
50DNA replication-independent nucleosome assembly (GO:0006336)3.34404628
51regulation of platelet aggregation (GO:0090330)3.33798452
52regulation of B cell receptor signaling pathway (GO:0050855)3.31812342
53DNA replication-dependent nucleosome organization (GO:0034723)3.31152026
54DNA replication-dependent nucleosome assembly (GO:0006335)3.31152026
55protein K11-linked deubiquitination (GO:0035871)3.29736515
56protein autoprocessing (GO:0016540)3.28545034
57iron ion import (GO:0097286)3.26095517
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26067374
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.24577909
60Peyers patch development (GO:0048541)3.23256141
61mucosal-associated lymphoid tissue development (GO:0048537)3.23256141
62microglial cell activation (GO:0001774)3.23182300
63bicarbonate transport (GO:0015701)3.21414046
64viral transcription (GO:0019083)3.19402056
65protein-cofactor linkage (GO:0018065)3.16857180
66mitotic chromosome condensation (GO:0007076)3.16772791
67response to arsenic-containing substance (GO:0046685)3.15759586
68regulation of granulocyte differentiation (GO:0030852)3.13155859
69kinetochore assembly (GO:0051382)3.11827162
70deoxyribonucleotide biosynthetic process (GO:0009263)3.11574815
71folic acid-containing compound biosynthetic process (GO:0009396)3.10051248
72DNA topological change (GO:0006265)3.09027026
73translational termination (GO:0006415)3.08172006
74histone exchange (GO:0043486)3.04995748
75DNA deamination (GO:0045006)3.04622257
76positive regulation of chromosome segregation (GO:0051984)3.03632948
77innate immune response in mucosa (GO:0002227)3.02533700
78cofactor biosynthetic process (GO:0051188)3.02493652
79dosage compensation (GO:0007549)3.01087522
80granulocyte differentiation (GO:0030851)3.00896677
81regulation of DNA endoreduplication (GO:0032875)2.99917489
82regulation of inositol phosphate biosynthetic process (GO:0010919)2.99870255
83regulation of gamma-delta T cell activation (GO:0046643)2.98806751
84nuclear pore complex assembly (GO:0051292)2.97284247
85microtubule depolymerization (GO:0007019)2.94881481
86IMP biosynthetic process (GO:0006188)2.92844887
87translational elongation (GO:0006414)2.89763140
88thrombin receptor signaling pathway (GO:0070493)2.87888782
89mitotic nuclear envelope disassembly (GO:0007077)2.83468534
90regulation of RNA export from nucleus (GO:0046831)2.82689887
91chromatin assembly or disassembly (GO:0006333)2.82323296
92very-low-density lipoprotein particle assembly (GO:0034379)2.82195628
93neutrophil activation (GO:0042119)2.82140095
94nucleosome assembly (GO:0006334)2.81768307
95negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.79166295
96definitive hemopoiesis (GO:0060216)2.77461980
97antibacterial humoral response (GO:0019731)2.76082793
98leukocyte degranulation (GO:0043299)2.74449824
99hemopoiesis (GO:0030097)2.74097776
100negative regulation of viral entry into host cell (GO:0046597)2.73667854
101histone mRNA catabolic process (GO:0071044)2.73541079
102purine-containing compound salvage (GO:0043101)2.72497948
103positive regulation of cellular response to oxidative stress (GO:1900409)2.71065875
104positive regulation of response to oxidative stress (GO:1902884)2.71065875
105hematopoietic stem cell differentiation (GO:0060218)2.69723805
106regulation of histone H3-K9 methylation (GO:0051570)2.69520855
107organelle membrane fusion (GO:0090174)2.69480566
108autophagic vacuole fusion (GO:0000046)2.69265485
109chromosome condensation (GO:0030261)2.66585880
110regulation of histone H3-K4 methylation (GO:0051569)2.65935405
111regulation of erythrocyte differentiation (GO:0045646)2.65031456
112telomere maintenance (GO:0000723)2.64926407
113telomere organization (GO:0032200)2.64812052
114negative regulation of histone methylation (GO:0031061)2.64649206
115positive T cell selection (GO:0043368)2.63964777
116positive regulation of erythrocyte differentiation (GO:0045648)2.63770348
117positive thymic T cell selection (GO:0045059)2.63202663
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62608563
119platelet formation (GO:0030220)2.62076400
120monoubiquitinated protein deubiquitination (GO:0035520)2.61590181
121positive regulation of megakaryocyte differentiation (GO:0045654)2.61538095
122translesion synthesis (GO:0019985)2.60718639
123protein localization to chromosome (GO:0034502)2.59605800
1242-deoxyribonucleotide biosynthetic process (GO:0009265)2.59149938
125deoxyribose phosphate biosynthetic process (GO:0046385)2.59149938
126membrane disassembly (GO:0030397)2.58454377
127nuclear envelope disassembly (GO:0051081)2.58454377
128actin filament capping (GO:0051693)2.58415579
129protein-DNA complex assembly (GO:0065004)2.56144191
130B cell receptor signaling pathway (GO:0050853)2.56132741
131cotranslational protein targeting to membrane (GO:0006613)2.55565664
132granulocyte activation (GO:0036230)2.55232302
133protein targeting to ER (GO:0045047)2.54859324
134mitotic metaphase plate congression (GO:0007080)2.54086539
135centriole replication (GO:0007099)2.54038758
136N-terminal protein amino acid acetylation (GO:0006474)2.53429720
137regulation of B cell differentiation (GO:0045577)2.52618787
138DNA synthesis involved in DNA repair (GO:0000731)2.52352664
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50765032
140translational initiation (GO:0006413)2.50636654
141glycine transport (GO:0015816)2.50501707
142iron-sulfur cluster assembly (GO:0016226)2.50177210
143metallo-sulfur cluster assembly (GO:0031163)2.50177210
144positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.49284186
145cellular protein complex disassembly (GO:0043624)2.49203330
146DNA packaging (GO:0006323)2.47485124
147histone H3-K4 trimethylation (GO:0080182)2.44311463
148antimicrobial humoral response (GO:0019730)2.44196616
149phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44186659
150Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43068068
151mucosal immune response (GO:0002385)2.42874350
152mitotic G2 DNA damage checkpoint (GO:0007095)2.42191100
153positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41027874
154nuclear pore organization (GO:0006999)2.40495520
155regulation of mast cell degranulation (GO:0043304)2.37450428
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36849130
157regulation of platelet activation (GO:0010543)2.34062713
158organ or tissue specific immune response (GO:0002251)2.33091741
159hydrogen peroxide catabolic process (GO:0042744)2.32477674
160natural killer cell differentiation (GO:0001779)2.31426472
161mitotic G2/M transition checkpoint (GO:0044818)2.30973895
162protoporphyrinogen IX metabolic process (GO:0046501)16.3087828
163protoporphyrinogen IX biosynthetic process (GO:0006782)15.8326999
164heme biosynthetic process (GO:0006783)11.4776218
165oxygen transport (GO:0015671)11.4467262
166porphyrin-containing compound biosynthetic process (GO:0006779)10.9318316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.59902080
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.58829742
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.64038445
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96206227
5GATA1_22025678_ChIP-Seq_K562_Human3.66478248
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08186737
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.94736853
8SCL_19346495_ChIP-Seq_HPC-7_Human2.91046580
9* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.89979100
10* GATA1_19941827_ChIP-Seq_MEL_Mouse2.57652530
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.56381448
12* GATA1_19941826_ChIP-Seq_K562_Human2.53593616
13* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.53589058
14* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.53391357
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.38879588
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37079646
17GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19759871
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19455442
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.17916208
20SPI1_23127762_ChIP-Seq_K562_Human2.17080926
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.11012023
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05732135
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03987965
24AR_21909140_ChIP-Seq_LNCAP_Human2.01774576
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01518276
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00493117
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.99175682
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97179978
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96679846
30MYB_26560356_Chip-Seq_TH2_Human1.96024722
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95068804
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94716065
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94519884
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.89554851
35VDR_23849224_ChIP-Seq_CD4+_Human1.87511663
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82646387
37MYB_26560356_Chip-Seq_TH1_Human1.75939463
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74900509
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74740246
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74578686
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70300481
42FOXP3_21729870_ChIP-Seq_TREG_Human1.68705462
43XRN2_22483619_ChIP-Seq_HELA_Human1.66900999
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62371454
45MYC_22102868_ChIP-Seq_BL_Human1.60695517
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.60285086
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60228428
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58703327
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53411844
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52458463
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.52055582
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48300073
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48114301
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48078814
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47253578
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46996545
57DCP1A_22483619_ChIP-Seq_HELA_Human1.45867303
58* GATA2_19941826_ChIP-Seq_K562_Human1.45428051
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44118300
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41876635
61VDR_21846776_ChIP-Seq_THP-1_Human1.41214208
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40757540
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.39594088
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39299328
65GATA3_27048872_Chip-Seq_THYMUS_Human1.38995468
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36791529
67* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35514226
68GABP_19822575_ChIP-Seq_HepG2_Human1.35108268
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34509522
70* RUNX_20019798_ChIP-Seq_JUKART_Human1.33296688
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.30805308
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26285236
73UTX_26944678_Chip-Seq_JUKART_Human1.25687648
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24744241
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24444070
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24126506
77TTF2_22483619_ChIP-Seq_HELA_Human1.23722357
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21405939
79* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20813169
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20322794
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20054035
82VDR_24763502_ChIP-Seq_THP-1_Human1.19834976
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19302282
84ELK1_19687146_ChIP-ChIP_HELA_Human1.19014670
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16185302
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15542506
87* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14899369
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14645636
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13736885
90KDM5A_27292631_Chip-Seq_BREAST_Human1.13503967
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13432802
92CIITA_25753668_ChIP-Seq_RAJI_Human1.11975666
93ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10627157
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10114509
95* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10096113
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08811519
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05591737
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04041103
99GATA3_26560356_Chip-Seq_TH2_Human1.02359521
100TCF7_22412390_ChIP-Seq_EML_Mouse1.00637382
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99590303
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98008725
103IRF1_19129219_ChIP-ChIP_H3396_Human0.97684270
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97269527
105* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97151227
106YY1_21170310_ChIP-Seq_MESCs_Mouse0.96782930
107* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95935876
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95731443
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95505648
110STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95407724
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94245007
112* RUNX1_22412390_ChIP-Seq_EML_Mouse0.92034052
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89646936
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87901787
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86758372
116RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86695276
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84620217
118TFEB_21752829_ChIP-Seq_HELA_Human0.84486876
119MAF_26560356_Chip-Seq_TH1_Human0.84466429
120SPI1_23547873_ChIP-Seq_NB4_Human0.83443085
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83251303
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82455481
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82071419
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.81594093
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81311053
126* NCOR1_26117541_ChIP-Seq_K562_Human0.80893770
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80760054
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80706301
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80695298
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.80061375
131EGR1_19374776_ChIP-ChIP_THP-1_Human0.79959957
132GATA3_26560356_Chip-Seq_TH1_Human0.79572241
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79287998
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78116847
135PU_27001747_Chip-Seq_BMDM_Mouse0.78098396
136ZNF263_19887448_ChIP-Seq_K562_Human0.77790147
137* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76870329
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76725410
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76402082
140MAF_26560356_Chip-Seq_TH2_Human0.74955473
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74813911
142TP53_22573176_ChIP-Seq_HFKS_Human0.74574053
143SPI1_20517297_ChIP-Seq_HL60_Human0.74335991
144EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71850030
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.71414027
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71231032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.67097649
2MP0010094_abnormal_chromosome_stability3.41000428
3MP0003693_abnormal_embryo_hatching2.89896756
4MP0005397_hematopoietic_system_phenotyp2.74175747
5MP0001545_abnormal_hematopoietic_system2.74175747
6MP0008057_abnormal_DNA_replication2.68553310
7MP0003077_abnormal_cell_cycle2.59753808
8MP0008260_abnormal_autophagy2.59230595
9MP0002396_abnormal_hematopoietic_system2.49010886
10MP0008995_early_reproductive_senescence2.35166407
11MP0003303_peritoneal_inflammation2.26626133
12MP0004957_abnormal_blastocyst_morpholog2.22458820
13MP0006054_spinal_hemorrhage2.18287602
14MP0008058_abnormal_DNA_repair2.05466000
15MP0005636_abnormal_mineral_homeostasis2.01384986
16MP0004147_increased_porphyrin_level10.7648694
17MP0003656_abnormal_erythrocyte_physiolo10.2415892
18MP0000490_abnormal_crypts_of1.92258924
19MP0000569_abnormal_digit_pigmentation1.88515384
20MP0005083_abnormal_biliary_tract1.74570734
21MP0002132_abnormal_respiratory_system1.73265993
22MP0005451_abnormal_body_composition1.72951745
23MP0002398_abnormal_bone_marrow1.66808764
24MP0006036_abnormal_mitochondrial_physio1.57866012
25MP0003172_abnormal_lysosome_physiology1.54762827
26MP0005464_abnormal_platelet_physiology1.54302846
27MP0003724_increased_susceptibility_to1.46271487
28MP0004808_abnormal_hematopoietic_stem1.45037610
29MP0003186_abnormal_redox_activity1.42677346
30MP0000689_abnormal_spleen_morphology1.39917941
31MP0002722_abnormal_immune_system1.39557377
32MP0009333_abnormal_splenocyte_physiolog1.33226622
33MP0008007_abnormal_cellular_replicative1.32753263
34MP0000685_abnormal_immune_system1.29068880
35MP0010307_abnormal_tumor_latency1.26938488
36MP0002429_abnormal_blood_cell1.26096029
37MP0000313_abnormal_cell_death1.16893431
38MP0000350_abnormal_cell_proliferation1.16071990
39MP0005410_abnormal_fertilization1.15362734
40MP0002166_altered_tumor_susceptibility1.08551997
41MP0002019_abnormal_tumor_incidence1.05371176
42MP0005671_abnormal_response_to1.05153193
43MP0008872_abnormal_physiological_respon1.04867461
44MP0003806_abnormal_nucleotide_metabolis1.04792643
45MP0008932_abnormal_embryonic_tissue1.04249025
46MP0002419_abnormal_innate_immunity1.02305237
47MP0008775_abnormal_heart_ventricle1.01192247
48MP0000703_abnormal_thymus_morphology1.01012979
49MP0008877_abnormal_DNA_methylation0.95688246
50MP0003878_abnormal_ear_physiology0.94287602
51MP0005377_hearing/vestibular/ear_phenot0.94287602
52MP0002095_abnormal_skin_pigmentation0.93252060
53MP0003221_abnormal_cardiomyocyte_apopto0.90581466
54MP0001529_abnormal_vocalization0.89571450
55MP0009931_abnormal_skin_appearance0.88571049
56MP0003787_abnormal_imprinting0.88210722
57MP0004130_abnormal_muscle_cell0.85919424
58MP0001730_embryonic_growth_arrest0.85603848
59MP0005501_abnormal_skin_physiology0.84705771
60MP0000749_muscle_degeneration0.84024249
61MP0002080_prenatal_lethality0.82652909
62MP0001929_abnormal_gametogenesis0.82151607
63MP0003436_decreased_susceptibility_to0.80658317
64MP0000716_abnormal_immune_system0.79492588
65MP0004883_abnormal_blood_vessel0.78836459
66MP0004381_abnormal_hair_follicle0.78816103
67MP0001764_abnormal_homeostasis0.77261807
68MP0003786_premature_aging0.75773143
69MP0002332_abnormal_exercise_endurance0.72096421
70MP0002405_respiratory_system_inflammati0.69981532
71MP0003763_abnormal_thymus_physiology0.68852220
72MP0004947_skin_inflammation0.68172522
73MP0004215_abnormal_myocardial_fiber0.67930695
74MP0003123_paternal_imprinting0.67583595
75MP0005645_abnormal_hypothalamus_physiol0.66539442
76MP0009764_decreased_sensitivity_to0.66151930
77MP0005266_abnormal_metabolism0.64919121
78MP0008770_decreased_survivor_rate0.63873055
79MP0001697_abnormal_embryo_size0.63700071
80MP0002086_abnormal_extraembryonic_tissu0.63365299
81MP0008004_abnormal_stomach_pH0.63186798
82MP0009765_abnormal_xenobiotic_induced0.62968675
83MP0005025_abnormal_response_to0.62715791
84MP0009697_abnormal_copulation0.62420918
85MP0003718_maternal_effect0.61905098
86MP0003828_pulmonary_edema0.61823593
87MP0002006_tumorigenesis0.61763949
88MP0001851_eye_inflammation0.61680024
89MP0003698_abnormal_male_reproductive0.61656273
90MP0001835_abnormal_antigen_presentation0.61512909
91MP0002210_abnormal_sex_determination0.60895676
92MP0004484_altered_response_of0.60561601
93MP0001845_abnormal_inflammatory_respons0.59966714
94MP0000858_altered_metastatic_potential0.59640289
95MP0002420_abnormal_adaptive_immunity0.59473502
96MP0002148_abnormal_hypersensitivity_rea0.59315764
97MP0001819_abnormal_immune_cell0.58335050
98MP0003191_abnormal_cellular_cholesterol0.57539326
99MP0005310_abnormal_salivary_gland0.57164054
100MP0000598_abnormal_liver_morphology0.57034268
101MP0000343_altered_response_to0.56213141
102MP0001800_abnormal_humoral_immune0.56088965
103MP0000609_abnormal_liver_physiology0.55920816
104MP0001145_abnormal_male_reproductive0.52598951
105MP0000465_gastrointestinal_hemorrhage0.51878982
106MP0000358_abnormal_cell_content/0.51555088
107MP0009763_increased_sensitivity_to0.51449125
108MP0002452_abnormal_antigen_presenting0.51086419
109MP0002161_abnormal_fertility/fecundity0.51058678
110MP0000653_abnormal_sex_gland0.50966116
111MP0001853_heart_inflammation0.50517669
112MP0005174_abnormal_tail_pigmentation0.50449715
113MP0008469_abnormal_protein_level0.49504277
114MP0001672_abnormal_embryogenesis/_devel0.49326340
115MP0005380_embryogenesis_phenotype0.49326340
116MP0003984_embryonic_growth_retardation0.46650597
117MP0005384_cellular_phenotype0.45947830
118MP0005621_abnormal_cell_physiology0.44749370
119MP0001243_abnormal_dermal_layer0.44594229
120MP0005075_abnormal_melanosome_morpholog0.44474594
121MP0002723_abnormal_immune_serum0.44375292
122MP0006035_abnormal_mitochondrial_morpho0.44336650
123MP0001663_abnormal_digestive_system0.44230822
124MP0002088_abnormal_embryonic_growth/wei0.43257375
125MP0003866_abnormal_defecation0.42927892
126MP0003567_abnormal_fetal_cardiomyocyte0.42177128
127MP0010352_gastrointestinal_tract_polyps0.41910693
128MP0009785_altered_susceptibility_to0.41622691
129MP0002877_abnormal_melanocyte_morpholog0.40715153
130MP0000015_abnormal_ear_pigmentation0.40636551
131MP0009278_abnormal_bone_marrow0.39557338
132MP0005319_abnormal_enzyme/_coenzyme0.38637853
133MP0005000_abnormal_immune_tolerance0.37680843

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)8.00188433
2Reticulocytosis (HP:0001923)7.23978277
3Hypochromic microcytic anemia (HP:0004840)7.23028503
4Abnormal hemoglobin (HP:0011902)7.12507415
5Diaphragmatic weakness (HP:0009113)5.85740754
6Abnormal number of erythroid precursors (HP:0012131)5.82317508
7Abnormality of reticulocytes (HP:0004312)5.52646473
8Paralysis (HP:0003470)5.47202767
9Abnormality of cells of the erythroid lineage (HP:0012130)5.45202445
10Cholelithiasis (HP:0001081)5.32119511
11Hyperbilirubinemia (HP:0002904)5.02690017
12Abnormal gallbladder morphology (HP:0012437)4.77327269
13Insomnia (HP:0100785)4.60872770
14Birth length less than 3rd percentile (HP:0003561)4.51604136
15Microcytic anemia (HP:0001935)4.44613943
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.28172231
17Ileus (HP:0002595)4.08835514
18Hypochromic anemia (HP:0001931)4.08666479
19Cutaneous photosensitivity (HP:0000992)4.07258435
20Osteomalacia (HP:0002749)4.01735525
21Increased mean platelet volume (HP:0011877)3.61433227
22Cholecystitis (HP:0001082)3.42093018
23Abnormal gallbladder physiology (HP:0012438)3.42093018
24Polycythemia (HP:0001901)3.40307893
25Petechiae (HP:0000967)3.37034440
26Abnormality of the gallbladder (HP:0005264)3.32016981
27Increased serum ferritin (HP:0003281)3.22123160
28Prolonged bleeding time (HP:0003010)3.07561084
29Gingival bleeding (HP:0000225)3.06147735
30Autoimmune hemolytic anemia (HP:0001890)2.94475128
31Pallor (HP:0000980)2.90566528
32Nausea (HP:0002018)2.90305557
33Abnormality of iron homeostasis (HP:0011031)2.86337659
34Hepatocellular carcinoma (HP:0001402)2.84839665
35Hyponatremia (HP:0002902)2.73694839
36Abnormality of the fingertips (HP:0001211)2.72560773
37Macrocytic anemia (HP:0001972)2.72283619
38Toxemia of pregnancy (HP:0100603)2.71265072
39Gastrointestinal infarctions (HP:0005244)2.64417395
40Abnormality of transition element cation homeostasis (HP:0011030)2.60363028
41Short middle phalanx of the 5th finger (HP:0004220)2.50491286
42Orthostatic hypotension (HP:0001278)2.49941093
43Reticulocytopenia (HP:0001896)2.48056599
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.47268934
45Menorrhagia (HP:0000132)2.43794839
46Hyperthyroidism (HP:0000836)2.35223410
47Spontaneous hematomas (HP:0007420)2.34543881
48Recurrent bacterial skin infections (HP:0005406)2.33586630
49Acute myeloid leukemia (HP:0004808)2.33258586
50Abnormality of sodium homeostasis (HP:0010931)2.31676021
51Aplastic anemia (HP:0001915)2.29116976
52Obstructive lung disease (HP:0006536)2.29035554
53Chronic obstructive pulmonary disease (HP:0006510)2.29035554
54Epistaxis (HP:0000421)2.28282983
55Aplasia/Hypoplasia of the earlobes (HP:0009906)2.26475183
56Truncus arteriosus (HP:0001660)2.26152345
57T lymphocytopenia (HP:0005403)2.20133003
58Onycholysis (HP:0001806)2.15936382
59Abnormality of T cell number (HP:0011839)2.15436630
60Recurrent abscess formation (HP:0002722)2.14294221
61Postural instability (HP:0002172)2.13008174
62Urticaria (HP:0001025)2.12400319
63Hypoparathyroidism (HP:0000829)2.09882615
64Cerebral palsy (HP:0100021)2.08971133
65Hypertensive crisis (HP:0100735)2.05098273
66Nonimmune hydrops fetalis (HP:0001790)2.03968364
67Visual hallucinations (HP:0002367)2.03858552
68Tinnitus (HP:0000360)2.01018435
69Abnormality of the heme biosynthetic pathway (HP:0010472)15.7054675
70Poikilocytosis (HP:0004447)10.7962340
71Granulocytopenia (HP:0001913)1.99904713
72Aplasia/Hypoplasia of the thymus (HP:0010515)1.99265734
73Recurrent viral infections (HP:0004429)1.97858897
74Amaurosis fugax (HP:0100576)1.97263162
75Slow saccadic eye movements (HP:0000514)1.96409286
76Recurrent fungal infections (HP:0002841)1.95899022
77Basal cell carcinoma (HP:0002671)1.93381510
78Absent epiphyses (HP:0010577)1.92977647
79Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92977647
80Abnormality of T cells (HP:0002843)1.89691194
81Arterial thrombosis (HP:0004420)1.88870691
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.88400716
83Fatigue (HP:0012378)1.86865202
84Myelodysplasia (HP:0002863)1.85180723
85Leukocytosis (HP:0001974)1.84631124
86Chromsome breakage (HP:0040012)1.84290028
87Abnormal spermatogenesis (HP:0008669)1.80855694
88Breast hypoplasia (HP:0003187)1.80236166
89Abnormal platelet function (HP:0011869)1.79343292
90Impaired platelet aggregation (HP:0003540)1.79343292
91Generalized hyperpigmentation (HP:0007440)1.77762346
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77735641
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77735641
94Purpura (HP:0000979)1.77001935
95Pustule (HP:0200039)1.76613861
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76415860
97Encephalitis (HP:0002383)1.76086011
98Autoimmune thrombocytopenia (HP:0001973)1.74876450
99Abnormality of dental color (HP:0011073)1.74732221
100Renal tubular acidosis (HP:0001947)1.74729362
101Delusions (HP:0000746)1.70707200
102Osteomyelitis (HP:0002754)1.69791724
103Thyroid carcinoma (HP:0002890)1.69771844
104Small intestinal stenosis (HP:0012848)1.69071983
105Duodenal stenosis (HP:0100867)1.69071983
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67895431
107Papillary thyroid carcinoma (HP:0002895)1.66683903
108Abnormality of chromosome stability (HP:0003220)1.66612157
109Seborrheic dermatitis (HP:0001051)1.65169431
110Bowel incontinence (HP:0002607)1.64419908
111Abnormal large intestine physiology (HP:0012700)1.64119510
112Acute hepatic failure (HP:0006554)1.64014742
113Abnormality of T cell physiology (HP:0011840)1.63988004
114Paresthesia (HP:0003401)1.62072409
115Pathologic fracture (HP:0002756)1.62054740
116Keratoconjunctivitis sicca (HP:0001097)1.61950547
117Long clavicles (HP:0000890)1.61944775
118Oral leukoplakia (HP:0002745)1.61769688
119Stomatitis (HP:0010280)1.61156186
120Abnormality of the preputium (HP:0100587)1.60950178
121Panhypogammaglobulinemia (HP:0003139)1.60385099
122Irregular epiphyses (HP:0010582)1.60076638
123Neoplasm of the liver (HP:0002896)1.59537233
124Broad palm (HP:0001169)1.58797597
125Eczematoid dermatitis (HP:0000976)1.58487379
126Eosinophilia (HP:0001880)1.58380493
127Hypopigmented skin patches (HP:0001053)1.58031511
128Dysautonomia (HP:0002459)1.57786456
129Stomach cancer (HP:0012126)1.57263268
130Bruising susceptibility (HP:0000978)1.57213082
131Abnormality of B cell number (HP:0010975)1.56667567
132Confusion (HP:0001289)1.55704345
133Abnormal blistering of the skin (HP:0008066)1.55426463
134Lymphoma (HP:0002665)1.51917965
135Azoospermia (HP:0000027)1.47373549
136Patellar aplasia (HP:0006443)1.47262385
137Cafe-au-lait spot (HP:0000957)1.45948311
138Meckel diverticulum (HP:0002245)1.45599286
139Increased serum lactate (HP:0002151)1.43904924
14011 pairs of ribs (HP:0000878)1.43597433
141Abnormality of the pons (HP:0007361)1.43375913
142High pitched voice (HP:0001620)1.43111932
143Exertional dyspnea (HP:0002875)1.41818002
144Hypoplasia of the pons (HP:0012110)1.40965440
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.39519999
146Thrombophlebitis (HP:0004418)1.39264694
147Abnormal platelet volume (HP:0011876)1.39153511
148Abnormality of the ileum (HP:0001549)1.38060120
149Bone marrow hypocellularity (HP:0005528)1.37977505
150IgM deficiency (HP:0002850)1.37571519
151Pancytopenia (HP:0001876)1.37205843
152Thrombocytosis (HP:0001894)1.35809636
153Recurrent sinusitis (HP:0011108)1.34727500
154Aplasia/Hypoplasia of the patella (HP:0006498)1.34259905
155Renal tubular dysfunction (HP:0000124)1.33788021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.32185078
2CDC74.44332642
3RIPK44.38342730
4TLK12.96228461
5NME22.95258870
6BUB12.90895889
7BRSK12.78179236
8VRK12.72430763
9NEK22.59755808
10WEE12.49541679
11BRSK22.35716596
12STK42.27186086
13PTK2B2.20629394
14PRPF4B1.94988102
15STK101.94685444
16BMPR21.94179868
17BMX1.92478374
18DYRK31.90371896
19PLK21.82512289
20EEF2K1.80813326
21WNK11.80390401
22STK161.76822383
23ZAK1.71409600
24FGR1.65787863
25PIK3CG1.56608108
26BCKDK1.55710664
27AURKB1.54188116
28PIM11.48936142
29SCYL21.46409555
30SRPK11.43279462
31MAP3K21.41092996
32PLK11.40747955
33TTK1.39986922
34KSR21.39791760
35AURKA1.39504942
36ATR1.35308336
37MAP4K11.25402180
38CDK41.25167173
39CHEK21.25139157
40CCNB11.24026169
41KSR11.22396739
42ACVR1B1.20752008
43MAP3K101.20555533
44MAPK111.19250351
45RPS6KB21.18301395
46MAP3K61.17399168
47FES1.17030225
48MAPKAPK51.16184745
49BLK1.15001998
50RAF11.14707637
51MAP3K81.11440610
52CDK121.11367710
53SYK1.10497638
54CDK191.08434727
55MST41.05363441
56TXK1.04894339
57RPS6KA51.01573010
58MAPKAPK30.99543812
59NEK10.98418067
60MAP3K110.97069069
61TRPM70.96943725
62MAP3K10.96441513
63CHEK10.95582956
64JAK30.95412547
65ITK0.92724619
66CLK10.92173934
67HCK0.90074768
68MAP3K50.89622076
69CDK70.89598956
70FLT30.89534128
71ATM0.87771850
72SGK20.87145834
73CDK80.86699501
74CAMK1D0.83319636
75PLK40.82372528
76GRK60.79146714
77FRK0.78889806
78LYN0.78001595
79PBK0.77477786
80EIF2AK30.74442845
81MAP2K40.72972433
82TGFBR20.72185427
83MAP2K30.72168730
84MAP2K10.71562753
85ABL20.68884230
86TYK20.68689076
87EIF2AK20.65878461
88SGK10.65836525
89PIM20.64961587
90RPS6KA40.64862451
91DAPK10.64527885
92PLK30.64409006
93JAK20.64284937
94MKNK10.64281401
95KDR0.63821798
96KIT0.63617261
97TAOK30.62772898
98SGK30.61513136
99CSNK2A10.60541318
100FGFR30.59576226
101PRKAA20.59486134
102CAMK1G0.59370194
103MATK0.59059574
104IRAK10.58481150
105AKT30.56824184
106CDK20.56559035
107NTRK30.55244820
108CSK0.55019633
109STK30.54534963
110LRRK20.53877374
111DYRK1A0.52903446
112MAP3K30.51982564
113LCK0.51525448
114NUAK10.51447368
115CDK60.51231469
116RET0.50888354
117TNK20.48981112
118IRAK40.48593303
119CSNK2A20.48425387
120CDK10.47125826
121BTK0.46598558
122IKBKE0.46184110
123CAMKK20.45951458
124PKN20.45925833
125MAPKAPK20.43883442
126HIPK20.43722801
127TAOK10.41749386
128IKBKB0.40403746
129MARK30.40285166
130MELK0.38434564
131TEC0.37379768
132NME10.36802247
133CDK90.36371912
134PRKCQ0.36322795
135AKT10.35467881
136ZAP700.34056310
137YES10.32788917
138PASK0.32693836
139BRD40.32130981
140PRKDC0.31821788
141RPS6KA60.31444837
142ERBB20.31395923
143CSNK1D0.31170390
144MKNK20.31007082
145MAPK120.30735511
146GRK70.30066316
147MAP3K140.28934274
148DAPK20.28830254
149DYRK1B0.28572161
150STK240.28477391
151GRK50.28182320
152TAOK20.27532586

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008607.16836403
2DNA replication_Homo sapiens_hsa030305.64542895
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.09484728
4Mismatch repair_Homo sapiens_hsa034303.78791175
5Vitamin B6 metabolism_Homo sapiens_hsa007503.58503601
6Systemic lupus erythematosus_Homo sapiens_hsa053223.40470851
7Ribosome_Homo sapiens_hsa030102.99515719
8Base excision repair_Homo sapiens_hsa034102.80030178
9Cell cycle_Homo sapiens_hsa041102.74618230
10Homologous recombination_Homo sapiens_hsa034402.61327968
11Nucleotide excision repair_Homo sapiens_hsa034202.57948918
12Spliceosome_Homo sapiens_hsa030402.20823307
13One carbon pool by folate_Homo sapiens_hsa006702.19773828
14Pyrimidine metabolism_Homo sapiens_hsa002402.17683682
15Proteasome_Homo sapiens_hsa030501.98275528
16Fanconi anemia pathway_Homo sapiens_hsa034601.97847391
17RNA transport_Homo sapiens_hsa030131.76039609
18Nitrogen metabolism_Homo sapiens_hsa009101.70169303
19Alcoholism_Homo sapiens_hsa050341.68783696
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68048178
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63427255
22African trypanosomiasis_Homo sapiens_hsa051431.60646327
23Non-homologous end-joining_Homo sapiens_hsa034501.59770708
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56329961
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53704413
26RNA polymerase_Homo sapiens_hsa030201.49285793
27Hematopoietic cell lineage_Homo sapiens_hsa046401.38003092
28p53 signaling pathway_Homo sapiens_hsa041151.34083583
29RNA degradation_Homo sapiens_hsa030181.28369449
30Sulfur relay system_Homo sapiens_hsa041221.27990788
31Purine metabolism_Homo sapiens_hsa002301.18204590
32Basal transcription factors_Homo sapiens_hsa030221.16270906
33mTOR signaling pathway_Homo sapiens_hsa041501.15821304
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14350279
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13435599
36T cell receptor signaling pathway_Homo sapiens_hsa046601.12903014
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.12617516
38Olfactory transduction_Homo sapiens_hsa047401.09118509
39Viral carcinogenesis_Homo sapiens_hsa052031.08938190
40Asthma_Homo sapiens_hsa053101.08625659
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08307433
42Type II diabetes mellitus_Homo sapiens_hsa049301.08012711
43Selenocompound metabolism_Homo sapiens_hsa004501.07206495
44Osteoclast differentiation_Homo sapiens_hsa043801.06409613
45ABC transporters_Homo sapiens_hsa020101.06064030
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05198213
47Inositol phosphate metabolism_Homo sapiens_hsa005621.04997929
48Herpes simplex infection_Homo sapiens_hsa051681.03636844
49Regulation of autophagy_Homo sapiens_hsa041401.00581837
50FoxO signaling pathway_Homo sapiens_hsa040680.99357458
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.97792523
52HIF-1 signaling pathway_Homo sapiens_hsa040660.97362598
53Renal cell carcinoma_Homo sapiens_hsa052110.95781264
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95215594
55VEGF signaling pathway_Homo sapiens_hsa043700.94070874
56Prolactin signaling pathway_Homo sapiens_hsa049170.91328744
57Parkinsons disease_Homo sapiens_hsa050120.88558707
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87023900
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86121259
60Glioma_Homo sapiens_hsa052140.85693991
61Malaria_Homo sapiens_hsa051440.84416874
62Endometrial cancer_Homo sapiens_hsa052130.83399495
63mRNA surveillance pathway_Homo sapiens_hsa030150.82553807
64Chemokine signaling pathway_Homo sapiens_hsa040620.82425607
65Tuberculosis_Homo sapiens_hsa051520.82217551
66Fatty acid biosynthesis_Homo sapiens_hsa000610.81890943
67Glutathione metabolism_Homo sapiens_hsa004800.80513282
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73574824
69Oocyte meiosis_Homo sapiens_hsa041140.72801375
70Pentose phosphate pathway_Homo sapiens_hsa000300.71913282
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71903543
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71106097
73Huntingtons disease_Homo sapiens_hsa050160.70727557
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68903603
75Dorso-ventral axis formation_Homo sapiens_hsa043200.68762326
76Graft-versus-host disease_Homo sapiens_hsa053320.67263822
77Allograft rejection_Homo sapiens_hsa053300.66692423
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.66245032
79Hepatitis C_Homo sapiens_hsa051600.65943765
80Folate biosynthesis_Homo sapiens_hsa007900.65567144
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65017968
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64460310
83Choline metabolism in cancer_Homo sapiens_hsa052310.63472013
84Measles_Homo sapiens_hsa051620.61232743
85Apoptosis_Homo sapiens_hsa042100.59945329
86Toxoplasmosis_Homo sapiens_hsa051450.59596323
87Epstein-Barr virus infection_Homo sapiens_hsa051690.59160136
88Autoimmune thyroid disease_Homo sapiens_hsa053200.57237994
89Antigen processing and presentation_Homo sapiens_hsa046120.57144880
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56711762
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56484834
92Prostate cancer_Homo sapiens_hsa052150.55072411
93Pyruvate metabolism_Homo sapiens_hsa006200.53731501
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53627895
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53479064
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53191893
97Staphylococcus aureus infection_Homo sapiens_hsa051500.52017545
98Small cell lung cancer_Homo sapiens_hsa052220.50886547
99Caffeine metabolism_Homo sapiens_hsa002320.50501965
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.46139909
101Hepatitis B_Homo sapiens_hsa051610.45677775
102TNF signaling pathway_Homo sapiens_hsa046680.45321345
103Oxidative phosphorylation_Homo sapiens_hsa001900.45022420
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44756422
105ErbB signaling pathway_Homo sapiens_hsa040120.44184807
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.44048671
107HTLV-I infection_Homo sapiens_hsa051660.43569895
108Bladder cancer_Homo sapiens_hsa052190.43393999
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41117812
110Metabolic pathways_Homo sapiens_hsa011000.41085986
111Protein export_Homo sapiens_hsa030600.40118578
112Primary immunodeficiency_Homo sapiens_hsa053400.39984200
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39045013
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38107312
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37823769
116Biosynthesis of amino acids_Homo sapiens_hsa012300.37276486
117Non-small cell lung cancer_Homo sapiens_hsa052230.37128301
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34856391
119Chronic myeloid leukemia_Homo sapiens_hsa052200.33280142
120Carbon metabolism_Homo sapiens_hsa012000.31974792
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.31557306
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31278560
123Legionellosis_Homo sapiens_hsa051340.26034328
124Influenza A_Homo sapiens_hsa051640.24481865
125N-Glycan biosynthesis_Homo sapiens_hsa005100.23691407
126Alzheimers disease_Homo sapiens_hsa050100.23148892
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20902555
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.17035677
129Thyroid cancer_Homo sapiens_hsa052160.16707526
130Platelet activation_Homo sapiens_hsa046110.15637350
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15631615
132Collecting duct acid secretion_Homo sapiens_hsa049660.15203069
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.12463521
134Arachidonic acid metabolism_Homo sapiens_hsa005900.12052575
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11826328
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.11114982
137Pancreatic cancer_Homo sapiens_hsa052120.08624451
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07827069
139Leishmaniasis_Homo sapiens_hsa051400.07415741
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07031437
141Acute myeloid leukemia_Homo sapiens_hsa052210.05812120
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05227440
143B cell receptor signaling pathway_Homo sapiens_hsa046620.04610330
144MicroRNAs in cancer_Homo sapiens_hsa052060.04033031
145AMPK signaling pathway_Homo sapiens_hsa041520.02308334
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.01213757
147Linoleic acid metabolism_Homo sapiens_hsa00591-0.0018720

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