HEMK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.73796428
2L-phenylalanine metabolic process (GO:0006558)5.73796428
3behavioral response to nicotine (GO:0035095)5.69500463
4valine metabolic process (GO:0006573)5.54293463
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46538917
6L-phenylalanine catabolic process (GO:0006559)5.46538917
7succinate metabolic process (GO:0006105)5.03245673
8fucose catabolic process (GO:0019317)4.96362997
9L-fucose metabolic process (GO:0042354)4.96362997
10L-fucose catabolic process (GO:0042355)4.96362997
11oxaloacetate metabolic process (GO:0006107)4.95082151
12ATP synthesis coupled proton transport (GO:0015986)4.81646045
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81646045
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73498611
15branched-chain amino acid catabolic process (GO:0009083)4.52911391
16aromatic amino acid family catabolic process (GO:0009074)4.43287808
17aspartate family amino acid catabolic process (GO:0009068)4.41903215
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39801440
19respiratory electron transport chain (GO:0022904)4.33601278
20branched-chain amino acid metabolic process (GO:0009081)4.30328560
21electron transport chain (GO:0022900)4.25083210
22tricarboxylic acid cycle (GO:0006099)4.24805447
232-oxoglutarate metabolic process (GO:0006103)4.24774191
24cellular ketone body metabolic process (GO:0046950)4.23751546
25urea cycle (GO:0000050)4.19293902
26urea metabolic process (GO:0019627)4.19293902
27dicarboxylic acid biosynthetic process (GO:0043650)4.17349631
28lysine catabolic process (GO:0006554)4.16343029
29lysine metabolic process (GO:0006553)4.16343029
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09928616
31protein import into peroxisome matrix (GO:0016558)4.08780059
32nitrogen cycle metabolic process (GO:0071941)4.08719542
33glyoxylate metabolic process (GO:0046487)4.05203023
34short-chain fatty acid metabolic process (GO:0046459)3.94677954
35kynurenine metabolic process (GO:0070189)3.88911322
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88316927
37NADH metabolic process (GO:0006734)3.86308570
38fatty acid beta-oxidation (GO:0006635)3.83017974
39coenzyme catabolic process (GO:0009109)3.78593762
40alpha-amino acid catabolic process (GO:1901606)3.75165507
41oxidative phosphorylation (GO:0006119)3.71964932
42acetyl-CoA metabolic process (GO:0006084)3.70590142
43tricarboxylic acid metabolic process (GO:0072350)3.69987634
44cellular response to exogenous dsRNA (GO:0071360)3.63833094
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62394130
46tryptophan metabolic process (GO:0006568)3.59313679
47indole-containing compound catabolic process (GO:0042436)3.58845312
48indolalkylamine catabolic process (GO:0046218)3.58845312
49tryptophan catabolic process (GO:0006569)3.58845312
50fatty acid catabolic process (GO:0009062)3.58267834
51serine family amino acid catabolic process (GO:0009071)3.58183159
52cellular amino acid catabolic process (GO:0009063)3.57055435
53glycine metabolic process (GO:0006544)3.57040996
54fatty acid oxidation (GO:0019395)3.56266345
55ketone body metabolic process (GO:1902224)3.52748559
56cilium or flagellum-dependent cell motility (GO:0001539)3.52695115
57indolalkylamine metabolic process (GO:0006586)3.52113478
58bile acid biosynthetic process (GO:0006699)3.51216845
59nephron tubule morphogenesis (GO:0072078)3.50366305
60nephron epithelium morphogenesis (GO:0072088)3.50366305
61lipid oxidation (GO:0034440)3.50228190
62DNA deamination (GO:0045006)3.48126312
63aromatic amino acid family metabolic process (GO:0009072)3.47475762
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47295332
65positive regulation of CREB transcription factor activity (GO:0032793)3.46371270
66detection of light stimulus involved in sensory perception (GO:0050962)3.44998146
67detection of light stimulus involved in visual perception (GO:0050908)3.44998146
68potassium ion export (GO:0071435)3.44702903
69monocarboxylic acid catabolic process (GO:0072329)3.44395530
704-hydroxyproline metabolic process (GO:0019471)3.43458569
71regulation of triglyceride catabolic process (GO:0010896)3.38635654
72sulfur amino acid catabolic process (GO:0000098)3.36998933
73protein complex biogenesis (GO:0070271)3.36564215
74organic acid catabolic process (GO:0016054)3.36377458
75carboxylic acid catabolic process (GO:0046395)3.36377458
76alpha-linolenic acid metabolic process (GO:0036109)3.35609106
77homocysteine metabolic process (GO:0050667)3.34225855
78cellular response to ATP (GO:0071318)3.32597175
79cysteine metabolic process (GO:0006534)3.32303167
80fucosylation (GO:0036065)3.31048106
81amino-acid betaine metabolic process (GO:0006577)3.28769387
82activated T cell proliferation (GO:0050798)3.28358100
83glutamate metabolic process (GO:0006536)3.27288019
84sulfation (GO:0051923)3.25242554
85dicarboxylic acid catabolic process (GO:0043649)3.23227107
86oxidative demethylation (GO:0070989)3.23014601
87inner mitochondrial membrane organization (GO:0007007)3.22810397
88ventricular cardiac muscle cell action potential (GO:0086005)3.20750886
89mitochondrial respiratory chain complex assembly (GO:0033108)3.20020631
90aldehyde catabolic process (GO:0046185)3.19242452
91dicarboxylic acid metabolic process (GO:0043648)3.19034715
92positive regulation of defense response to virus by host (GO:0002230)3.18022214
93negative regulation of telomere maintenance (GO:0032205)3.16502269
94ethanol oxidation (GO:0006069)3.13334975
95NAD metabolic process (GO:0019674)3.12622790
96biotin metabolic process (GO:0006768)3.07369259
97preassembly of GPI anchor in ER membrane (GO:0016254)3.06824116
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05333881
99negative regulation of translation, ncRNA-mediated (GO:0040033)3.05333881
100regulation of translation, ncRNA-mediated (GO:0045974)3.05333881
101epithelial cilium movement (GO:0003351)3.05250038
102serine family amino acid biosynthetic process (GO:0009070)3.02390594
103detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.02166974
104cellular modified amino acid catabolic process (GO:0042219)3.02154097
105serine family amino acid metabolic process (GO:0009069)3.00826073
106axoneme assembly (GO:0035082)3.00726711
107ATP biosynthetic process (GO:0006754)3.00603268
108fatty acid transmembrane transport (GO:1902001)3.00555823
109peptidyl-glutamic acid carboxylation (GO:0017187)2.99333048
110protein carboxylation (GO:0018214)2.99333048
111high-density lipoprotein particle remodeling (GO:0034375)2.98675157
112response to pheromone (GO:0019236)2.98436031
113triglyceride homeostasis (GO:0070328)2.98180461
114acylglycerol homeostasis (GO:0055090)2.98180461
115response to misfolded protein (GO:0051788)2.97278100
116complement activation, alternative pathway (GO:0006957)2.96938759
117negative regulation of cholesterol transport (GO:0032375)2.94708474
118negative regulation of sterol transport (GO:0032372)2.94708474
119respiratory chain complex IV assembly (GO:0008535)2.93686039
120cardiovascular system development (GO:0072358)2.93338983
121regulation of hippo signaling (GO:0035330)2.92947049
122imidazole-containing compound metabolic process (GO:0052803)2.91503468
123drug catabolic process (GO:0042737)2.91393296
124tyrosine metabolic process (GO:0006570)2.90560657
125autophagic vacuole fusion (GO:0000046)2.90388960
126plasma lipoprotein particle clearance (GO:0034381)2.90254781
127pantothenate metabolic process (GO:0015939)2.88047524
128coenzyme A metabolic process (GO:0015936)2.87686907
129regulation of action potential (GO:0098900)2.87168434
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.86388950
131NADH dehydrogenase complex assembly (GO:0010257)2.86388950
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86388950
133cofactor catabolic process (GO:0051187)2.85459973
134fatty acid homeostasis (GO:0055089)2.85027302
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84536410
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84536410
137regulation of protein activation cascade (GO:2000257)2.84520799
138NAD biosynthetic process (GO:0009435)2.84062949
139nonmotile primary cilium assembly (GO:0035058)2.83299836
140snRNA transcription (GO:0009301)2.81569106
141cilium movement (GO:0003341)2.78472891
142negative regulation of mast cell activation (GO:0033004)2.77832533
143histone H3-K9 methylation (GO:0051567)2.71567664
144neuronal action potential (GO:0019228)2.71228870
145S-adenosylmethionine metabolic process (GO:0046500)2.69963748
146positive regulation of fatty acid oxidation (GO:0046321)2.68129076
147positive regulation of fatty acid beta-oxidation (GO:0032000)2.66255286
148amine catabolic process (GO:0009310)2.65985428
149cellular biogenic amine catabolic process (GO:0042402)2.65985428
150interkinetic nuclear migration (GO:0022027)2.64953004
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62570850
152exogenous drug catabolic process (GO:0042738)2.60404983
153negative regulation of reactive oxygen species metabolic process (GO:2000378)2.56343413
154ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.56264107
155renal tubule morphogenesis (GO:0061333)2.56213601
156cornea development in camera-type eye (GO:0061303)2.54673285
157prenylation (GO:0097354)2.52642081
158protein prenylation (GO:0018342)2.52642081
159positive regulation of fatty acid transport (GO:2000193)2.52630746
160negative T cell selection (GO:0043383)2.51233046
161purinergic nucleotide receptor signaling pathway (GO:0035590)2.51209059
162reciprocal meiotic recombination (GO:0007131)2.48063574
163reciprocal DNA recombination (GO:0035825)2.48063574
164indole-containing compound metabolic process (GO:0042430)2.47874267
165regulation of gene silencing by RNA (GO:0060966)2.46122337
166regulation of posttranscriptional gene silencing (GO:0060147)2.46122337
167regulation of gene silencing by miRNA (GO:0060964)2.46122337
168negative thymic T cell selection (GO:0045060)2.46051466
169water-soluble vitamin biosynthetic process (GO:0042364)2.44602499
170cAMP catabolic process (GO:0006198)2.43021803
171neural tube formation (GO:0001841)2.42951348
172mitotic cell cycle arrest (GO:0071850)2.42058031
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.41561564
174urinary tract smooth muscle contraction (GO:0014848)2.41015619
175motile cilium assembly (GO:0044458)2.40225375
176rhodopsin mediated signaling pathway (GO:0016056)2.37983875
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37715299
178interferon-gamma production (GO:0032609)2.37078854
179head development (GO:0060322)2.36692990
180organelle membrane fusion (GO:0090174)2.35326232
181protein targeting to peroxisome (GO:0006625)2.35278162
182establishment of protein localization to peroxisome (GO:0072663)2.35278162
183protein localization to peroxisome (GO:0072662)2.35278162
184tRNA modification (GO:0006400)2.34655180
185endosome to melanosome transport (GO:0035646)2.34597435
186endosome to pigment granule transport (GO:0043485)2.34597435
187alkaloid metabolic process (GO:0009820)2.34527268
188histone H3-K9 modification (GO:0061647)2.33358726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.21525472
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.01553785
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.08044603
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.55991267
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.42991915
6ZNF274_21170338_ChIP-Seq_K562_Hela4.07248373
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.44239950
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34645993
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.34112991
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31088877
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.19271745
12VDR_22108803_ChIP-Seq_LS180_Human3.11752997
13EZH2_22144423_ChIP-Seq_EOC_Human2.99536418
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97604794
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.76129550
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74581587
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.74062725
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.69779451
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68678350
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63222712
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48935078
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.41989367
23* GABP_17652178_ChIP-ChIP_JURKAT_Human2.41098466
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36861955
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32455479
26* ETS1_20019798_ChIP-Seq_JURKAT_Human2.23192062
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20554564
28DROSHA_22980978_ChIP-Seq_HELA_Human2.10236131
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09015349
30GBX2_23144817_ChIP-Seq_PC3_Human2.08674132
31AR_21572438_ChIP-Seq_LNCaP_Human2.03760809
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96031976
33* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95713095
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95036366
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91532286
36DCP1A_22483619_ChIP-Seq_HELA_Human1.91261423
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.90586082
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.86681321
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81270705
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81012980
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.78682483
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75360319
43IRF1_19129219_ChIP-ChIP_H3396_Human1.65350002
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64871952
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62979480
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.62094663
47ER_23166858_ChIP-Seq_MCF-7_Human1.59565783
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58906937
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56060584
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54099884
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52488803
52* GATA3_21878914_ChIP-Seq_MCF-7_Human1.51011930
53* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50382324
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49217054
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48014309
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47957667
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47696074
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43641007
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42995112
60GATA1_22025678_ChIP-Seq_K562_Human1.42687309
61XRN2_22483619_ChIP-Seq_HELA_Human1.42394503
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41956712
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39574005
64E2F1_20622854_ChIP-Seq_HELA_Human1.39388752
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36711465
66OCT4_20526341_ChIP-Seq_ESCs_Human1.36593476
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36025471
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36025471
69GABP_19822575_ChIP-Seq_HepG2_Human1.35751775
70TP53_22573176_ChIP-Seq_HFKS_Human1.35500965
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34466965
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.32838087
73REST_21632747_ChIP-Seq_MESCs_Mouse1.32691854
74BCAT_22108803_ChIP-Seq_LS180_Human1.31054312
75PHF8_20622854_ChIP-Seq_HELA_Human1.30972994
76EWS_26573619_Chip-Seq_HEK293_Human1.30910924
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30208054
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29904563
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28364155
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.28268377
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26411848
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26351549
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.25287216
84NANOG_20526341_ChIP-Seq_ESCs_Human1.23254711
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22880435
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22860126
87IGF1R_20145208_ChIP-Seq_DFB_Human1.22658361
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22580424
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20990266
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.20990266
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20924038
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20813731
93RUNX_20019798_ChIP-Seq_JUKART_Human1.20709274
94STAT3_23295773_ChIP-Seq_U87_Human1.20407091
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.20357943
96MYC_19829295_ChIP-Seq_ESCs_Human1.20068821
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.19971651
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19704146
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19603670
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19334993
101P53_21459846_ChIP-Seq_SAOS-2_Human1.19056676
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15940208
103NCOR_22424771_ChIP-Seq_293T_Human1.14391074
104P68_20966046_ChIP-Seq_HELA_Human1.13411730
105RAC3_21632823_ChIP-Seq_H3396_Human1.13105219
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12387967
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12136358
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12018719
109P300_27268052_Chip-Seq_Bcells_Human1.12008025
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11947977
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09100341
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08568889
113* VDR_23849224_ChIP-Seq_CD4+_Human1.07714583
114HOXB7_26014856_ChIP-Seq_BT474_Human1.07334278
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06953988
116HTT_18923047_ChIP-ChIP_STHdh_Human1.05949365
117RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05349377
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.04852365
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04070561
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04032277
121GATA3_26560356_Chip-Seq_TH2_Human1.03937373
122AR_20517297_ChIP-Seq_VCAP_Human1.03918804
123FUS_26573619_Chip-Seq_HEK293_Human1.03117910
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.02914442
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02685707
126TP53_16413492_ChIP-PET_HCT116_Human1.02204079
127TAF15_26573619_Chip-Seq_HEK293_Human1.01990493
128BCL6_27268052_Chip-Seq_Bcells_Human1.01621012
129* TCF4_23295773_ChIP-Seq_U87_Human1.01144581
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01019718
131BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00948124
132RXR_22108803_ChIP-Seq_LS180_Human1.00626650
133RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99793486
134* FOXP3_21729870_ChIP-Seq_TREG_Human0.98933091
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98394504
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.98142692
137KDM5A_27292631_Chip-Seq_BREAST_Human0.97996562
138* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97775078
139JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97038476
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.96822925
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.96079384
142AR_25329375_ChIP-Seq_VCAP_Human0.95732102
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94895846
144* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94820978
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94578929
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.94208657
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93800730
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92145885
149CTCF_27219007_Chip-Seq_Bcells_Human0.91499021
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91392458
151CTCF_20526341_ChIP-Seq_ESCs_Human0.90366126
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89881346
153CBP_20019798_ChIP-Seq_JUKART_Human0.89881346
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89756577
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.89497436
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89393582
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88292185
158TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87620457
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.85956760
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85696475
161ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84643064
162CIITA_25753668_ChIP-Seq_RAJI_Human0.84200123
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83994534
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83957218
165ERA_21632823_ChIP-Seq_H3396_Human0.83617079
166STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81949981
167BCOR_27268052_Chip-Seq_Bcells_Human0.81682212
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80665425
169EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80452592
170* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80212850
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80129259
172CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79093133
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78437505
174TAF2_19829295_ChIP-Seq_ESCs_Human0.78195843
175NELFA_20434984_ChIP-Seq_ESCs_Mouse0.76677735
176LXR_22292898_ChIP-Seq_THP-1_Human0.76260556
177ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75621569
178SOX17_20123909_ChIP-Seq_XEN_Mouse0.74140845
179LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73686380
180ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73008634
181* SPI1_20517297_ChIP-Seq_HL60_Human0.72371136
182TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72092167
183PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71289867
184* STAT1_20625510_ChIP-Seq_HELA_Human0.71246147
185SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71210012
186SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70138001
187NANOG_18555785_ChIP-Seq_MESCs_Mouse0.69857967
188PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69795496
189SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69582670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.92810647
2MP0005365_abnormal_bile_salt4.40370713
3MP0008004_abnormal_stomach_pH4.22681559
4MP0005360_urolithiasis4.22350738
5MP0003806_abnormal_nucleotide_metabolis4.01163828
6MP0005085_abnormal_gallbladder_physiolo3.97619663
7MP0002837_dystrophic_cardiac_calcinosis3.76440533
8MP0003136_yellow_coat_color3.05071803
9MP0005174_abnormal_tail_pigmentation2.86630916
10MP0003011_delayed_dark_adaptation2.73913650
11MP0003252_abnormal_bile_duct2.71750232
12MP0008875_abnormal_xenobiotic_pharmacok2.60953157
13MP0005332_abnormal_amino_acid2.49465418
14MP0000569_abnormal_digit_pigmentation2.47485503
15MP0010329_abnormal_lipoprotein_level2.42815631
16MP0004043_abnormal_pH_regulation2.42710326
17MP0001986_abnormal_taste_sensitivity2.39632426
18MP0003646_muscle_fatigue2.36979652
19MP0006036_abnormal_mitochondrial_physio2.34222597
20MP0009840_abnormal_foam_cell2.22155270
21MP0001764_abnormal_homeostasis2.11497406
22MP0001968_abnormal_touch/_nociception2.04030821
23MP0001666_abnormal_nutrient_absorption1.98991503
24MP0005171_absent_coat_pigmentation1.98922742
25MP0002876_abnormal_thyroid_physiology1.98755178
26MP0001873_stomach_inflammation1.93026055
27MP0004019_abnormal_vitamin_homeostasis1.91861700
28MP0003186_abnormal_redox_activity1.87029046
29MP0006035_abnormal_mitochondrial_morpho1.86331301
30MP0005083_abnormal_biliary_tract1.86086826
31MP0008872_abnormal_physiological_respon1.84402101
32MP0005551_abnormal_eye_electrophysiolog1.81190277
33MP0002653_abnormal_ependyma_morphology1.81148202
34MP0003195_calcinosis1.80749018
35MP0003724_increased_susceptibility_to1.75875115
36MP0004084_abnormal_cardiac_muscle1.74932332
37MP0005319_abnormal_enzyme/_coenzyme1.73295348
38MP0002118_abnormal_lipid_homeostasis1.71466266
39MP0004215_abnormal_myocardial_fiber1.69380798
40MP0000609_abnormal_liver_physiology1.66014172
41MP0005330_cardiomyopathy1.65403139
42MP0000015_abnormal_ear_pigmentation1.63364219
43MP0005584_abnormal_enzyme/coenzyme_acti1.56175556
44MP0000685_abnormal_immune_system1.54448106
45MP0002928_abnormal_bile_duct1.54347128
46MP0004130_abnormal_muscle_cell1.53088240
47MP0004036_abnormal_muscle_relaxation1.47854384
48MP0004381_abnormal_hair_follicle1.47441187
49MP0002971_abnormal_brown_adipose1.47107347
50MP0002138_abnormal_hepatobiliary_system1.44628899
51MP0000566_synostosis1.42621171
52MP0005646_abnormal_pituitary_gland1.39929084
53MP0002638_abnormal_pupillary_reflex1.38688249
54MP0005423_abnormal_somatic_nervous1.38121794
55MP0003137_abnormal_impulse_conducting1.37711012
56MP0005535_abnormal_body_temperature1.35497286
57MP0004885_abnormal_endolymph1.35481932
58MP0001800_abnormal_humoral_immune1.31741927
59MP0004147_increased_porphyrin_level1.30371325
60MP0002735_abnormal_chemical_nociception1.30368406
61MP0009745_abnormal_behavioral_response1.29342230
62MP0008877_abnormal_DNA_methylation1.28605444
63MP0001485_abnormal_pinna_reflex1.25635521
64MP0000427_abnormal_hair_cycle1.24558613
65MP0009643_abnormal_urine_homeostasis1.24035329
66MP0006292_abnormal_olfactory_placode1.23503211
67MP0001501_abnormal_sleep_pattern1.23138508
68MP0002078_abnormal_glucose_homeostasis1.22925785
69MP0005389_reproductive_system_phenotype1.21541570
70MP0001502_abnormal_circadian_rhythm1.19778831
71MP0002269_muscular_atrophy1.19563504
72MP0000631_abnormal_neuroendocrine_gland1.19255280
73MP0001919_abnormal_reproductive_system1.16227399
74MP0003436_decreased_susceptibility_to1.15910181
75MP0001663_abnormal_digestive_system1.15766848
76MP0005084_abnormal_gallbladder_morpholo1.15746254
77MP0009697_abnormal_copulation1.13758766
78MP0001853_heart_inflammation1.13539184
79MP0000751_myopathy1.13488685
80MP0008961_abnormal_basal_metabolism1.12509421
81MP0000749_muscle_degeneration1.11794139
82MP0005075_abnormal_melanosome_morpholog1.11655064
83MP0000604_amyloidosis1.10912634
84MP0001664_abnormal_digestion1.10871893
85MP0005377_hearing/vestibular/ear_phenot1.07040899
86MP0003878_abnormal_ear_physiology1.07040899
87MP0005266_abnormal_metabolism1.06374336
88MP0004133_heterotaxia1.05684165
89MP0000383_abnormal_hair_follicle1.05598053
90MP0003763_abnormal_thymus_physiology1.04920809
91MP0002102_abnormal_ear_morphology1.04776125
92MP0002095_abnormal_skin_pigmentation1.03731557
93MP0000538_abnormal_urinary_bladder1.03608046
94MP0001970_abnormal_pain_threshold1.03477148
95MP0002822_catalepsy1.03285908
96MP0004742_abnormal_vestibular_system1.03283391
97MP0005387_immune_system_phenotype1.03156535
98MP0001790_abnormal_immune_system1.03156535
99MP0000371_diluted_coat_color1.03123701
100MP0002933_joint_inflammation1.02939393
101MP0005253_abnormal_eye_physiology1.02913762
102MP0002160_abnormal_reproductive_system1.02861440
103MP0000750_abnormal_muscle_regeneration1.02254531
104MP0001529_abnormal_vocalization1.01919104
105MP0008469_abnormal_protein_level1.01876312
106MP0005671_abnormal_response_to1.01749518
107MP0002557_abnormal_social/conspecific_i1.01600498
108MP0005666_abnormal_adipose_tissue1.01042441
109MP0002693_abnormal_pancreas_physiology1.00690269
110MP0004142_abnormal_muscle_tone1.00171875
111MP0008995_early_reproductive_senescence0.99168103
112MP0002736_abnormal_nociception_after0.99029621
113MP0002163_abnormal_gland_morphology0.98766898
114MP0008775_abnormal_heart_ventricle0.97359544
115MP0006276_abnormal_autonomic_nervous0.97086340
116MP0000026_abnormal_inner_ear0.96733675
117MP0005636_abnormal_mineral_homeostasis0.96611206
118MP0003329_amyloid_beta_deposits0.96435782
119MP0000372_irregular_coat_pigmentation0.96308393
120MP0002332_abnormal_exercise_endurance0.95338358
121MP0009763_increased_sensitivity_to0.95232859
122MP0003191_abnormal_cellular_cholesterol0.94501441
123MP0002972_abnormal_cardiac_muscle0.93758334
124MP0001765_abnormal_ion_homeostasis0.93748812
125MP0002572_abnormal_emotion/affect_behav0.92593384
126MP0009642_abnormal_blood_homeostasis0.91870804
127MP0003866_abnormal_defecation0.91807531
128MP0005385_cardiovascular_system_phenoty0.91736593
129MP0001544_abnormal_cardiovascular_syste0.91736593
130MP0004924_abnormal_behavior0.91491761
131MP0005386_behavior/neurological_phenoty0.91491761
132MP0000470_abnormal_stomach_morphology0.90614448
133MP0001756_abnormal_urination0.89912711
134MP0005448_abnormal_energy_balance0.89802862
135MP0001905_abnormal_dopamine_level0.87345604
136MP0009046_muscle_twitch0.86521739
137MP0006072_abnormal_retinal_apoptosis0.86293845
138MP0003959_abnormal_lean_body0.85695435
139MP0005195_abnormal_posterior_eye0.85513548
140MP0005645_abnormal_hypothalamus_physiol0.85494250
141MP0001486_abnormal_startle_reflex0.85113024
142MP0005334_abnormal_fat_pad0.84291063
143MP0005620_abnormal_muscle_contractility0.83662936
144MP0002938_white_spotting0.82556533
145MP0002272_abnormal_nervous_system0.82521273
146MP0001324_abnormal_eye_pigmentation0.82515372
147MP0002733_abnormal_thermal_nociception0.82006191
148MP0005376_homeostasis/metabolism_phenot0.80840329
149MP0002723_abnormal_immune_serum0.80390079
150MP0005220_abnormal_exocrine_pancreas0.79447742
151MP0004510_myositis0.78704205
152MP0009765_abnormal_xenobiotic_induced0.78104515
153MP0000598_abnormal_liver_morphology0.77135861
154MP0008873_increased_physiological_sensi0.76530224
155MP0009785_altered_susceptibility_to0.76439812
156MP0001944_abnormal_pancreas_morphology0.76230778
157MP0004145_abnormal_muscle_electrophysio0.74819930
158MP0004085_abnormal_heartbeat0.74684446
159MP0005670_abnormal_white_adipose0.74525843
160MP0009764_decreased_sensitivity_to0.73961683
161MP0004087_abnormal_muscle_fiber0.73747361
162MP0002106_abnormal_muscle_physiology0.73502724
163MP0001727_abnormal_embryo_implantation0.71973579
164MP0002127_abnormal_cardiovascular_syste0.69967397
165MP0003953_abnormal_hormone_level0.69484197
166MP0000230_abnormal_systemic_arterial0.68940319
167MP0005451_abnormal_body_composition0.66058306
168MP0005375_adipose_tissue_phenotype0.65924654
169MP0003303_peritoneal_inflammation0.64283696
170MP0005165_increased_susceptibility_to0.64042410
171MP0003656_abnormal_erythrocyte_physiolo0.62527607

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.01645724
2Acute necrotizing encephalopathy (HP:0006965)4.96576551
3Acute encephalopathy (HP:0006846)4.95639299
4Cerebral edema (HP:0002181)4.54437500
5Hepatic necrosis (HP:0002605)4.53934097
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.48529864
7Hepatocellular necrosis (HP:0001404)4.35846527
8Pancreatic cysts (HP:0001737)4.27852186
9Mitochondrial inheritance (HP:0001427)4.21628044
10Hypobetalipoproteinemia (HP:0003563)4.11596789
11Increased muscle lipid content (HP:0009058)4.09809220
12Increased intramyocellular lipid droplets (HP:0012240)4.09479669
13Increased CSF lactate (HP:0002490)4.00042291
14Progressive macrocephaly (HP:0004481)3.96400438
15Abnormality of fatty-acid metabolism (HP:0004359)3.96065572
16Abnormality of midbrain morphology (HP:0002418)3.80753374
17Molar tooth sign on MRI (HP:0002419)3.80753374
18Hypoglycemic coma (HP:0001325)3.74286996
19Congenital stationary night blindness (HP:0007642)3.70023806
20Nephronophthisis (HP:0000090)3.61269023
21Lipid accumulation in hepatocytes (HP:0006561)3.57977321
22Attenuation of retinal blood vessels (HP:0007843)3.56255326
23Hyperglycinemia (HP:0002154)3.54935594
24Pancreatic fibrosis (HP:0100732)3.51905640
25Hyperammonemia (HP:0001987)3.49493711
26Hyperglycinuria (HP:0003108)3.46635899
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45151994
28True hermaphroditism (HP:0010459)3.42346301
29Abnormality of the renal cortex (HP:0011035)3.39077361
30Increased hepatocellular lipid droplets (HP:0006565)3.38454388
31Lethargy (HP:0001254)3.37138637
32Abnormality of serine family amino acid metabolism (HP:0010894)3.34291563
33Abnormality of glycine metabolism (HP:0010895)3.34291563
34Abnormal drinking behavior (HP:0030082)3.33773688
35Polydipsia (HP:0001959)3.33773688
36Ketosis (HP:0001946)3.33029591
37Myoglobinuria (HP:0002913)3.31738938
38Lactic acidosis (HP:0003128)3.27453279
39Abnormality of the renal medulla (HP:0100957)3.25779234
40Type II lissencephaly (HP:0007260)3.22459852
41Renal Fanconi syndrome (HP:0001994)3.20243951
42Ventricular fibrillation (HP:0001663)3.19666573
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.17022391
44Dicarboxylic aciduria (HP:0003215)3.17022391
45Intrahepatic cholestasis (HP:0001406)3.15416090
46Prolonged partial thromboplastin time (HP:0003645)3.13769468
47Large for gestational age (HP:0001520)3.12344460
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11829637
49Genetic anticipation (HP:0003743)3.11605767
50Tubular atrophy (HP:0000092)3.08315591
51Decreased circulating renin level (HP:0003351)3.08017648
52Hyperventilation (HP:0002883)3.06952345
53Chronic hepatic failure (HP:0100626)3.06438312
54Exercise intolerance (HP:0003546)3.04168466
55Deep venous thrombosis (HP:0002625)2.96129948
56Delayed CNS myelination (HP:0002188)2.92915530
57Cystic liver disease (HP:0006706)2.92581110
58Generalized aminoaciduria (HP:0002909)2.89845021
59Abnormality of renal resorption (HP:0011038)2.88174463
60Ketoacidosis (HP:0001993)2.87735452
61Hyperlipoproteinemia (HP:0010980)2.84044735
62Medial flaring of the eyebrow (HP:0010747)2.82421905
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82324943
64Birth length less than 3rd percentile (HP:0003561)2.82103131
65Exertional dyspnea (HP:0002875)2.81476461
66Xanthomatosis (HP:0000991)2.78773568
67Respiratory failure (HP:0002878)2.77969754
68Patellar aplasia (HP:0006443)2.76973529
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74098996
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74098996
71Syncope (HP:0001279)2.73907095
72Optic disc pallor (HP:0000543)2.70665395
73Prolonged QT interval (HP:0001657)2.70535363
74Abnormality of urine glucose concentration (HP:0011016)2.68325332
75Glycosuria (HP:0003076)2.68325332
76Hypolipoproteinemia (HP:0010981)2.68177976
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.66701557
78Rhabdomyolysis (HP:0003201)2.63183905
79Increased serum lactate (HP:0002151)2.63038367
80Aplasia/Hypoplasia of the patella (HP:0006498)2.61973916
81Duplicated collecting system (HP:0000081)2.60151481
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59435554
83Hypoglycemic seizures (HP:0002173)2.58390574
84Leukodystrophy (HP:0002415)2.55929612
85Protruding tongue (HP:0010808)2.55696973
86Central scotoma (HP:0000603)2.52372603
87Abnormality of the renal collecting system (HP:0004742)2.52089229
88Inability to walk (HP:0002540)2.51994137
89Polyuria (HP:0000103)2.51491572
90Progressive cerebellar ataxia (HP:0002073)2.50932586
91Metabolic acidosis (HP:0001942)2.46983229
92Clumsiness (HP:0002312)2.44961706
93Stomach cancer (HP:0012126)2.44872244
94Abolished electroretinogram (ERG) (HP:0000550)2.43779796
95Palpitations (HP:0001962)2.43751936
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43271723
97Exercise-induced myalgia (HP:0003738)2.43259601
98CNS demyelination (HP:0007305)2.42765065
99Cerebellar dysplasia (HP:0007033)2.42320432
100Pendular nystagmus (HP:0012043)2.41756877
101Hypoplasia of the pons (HP:0012110)2.39780418
102Chorioretinal atrophy (HP:0000533)2.38271023
103Absent/shortened dynein arms (HP:0200106)2.38263185
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.38263185
105Severe muscular hypotonia (HP:0006829)2.37462157
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36598429
107Abnormality of the pons (HP:0007361)2.35751452
108Vomiting (HP:0002013)2.35210433
109Hyperinsulinemic hypoglycemia (HP:0000825)2.32838137
110Gait imbalance (HP:0002141)2.29311789
111Congenital hepatic fibrosis (HP:0002612)2.28488290
112Abnormality of alanine metabolism (HP:0010916)2.25892797
113Hyperalaninemia (HP:0003348)2.25892797
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25892797
115Acute hepatic failure (HP:0006554)2.25656386
116Congenital primary aphakia (HP:0007707)2.23322682
117Progressive inability to walk (HP:0002505)2.22696589
118Mesangial abnormality (HP:0001966)2.21445752
119Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20877496
120Concave nail (HP:0001598)2.20060760
121Abnormality of pyrimidine metabolism (HP:0004353)2.19777904
122Ragged-red muscle fibers (HP:0003200)2.18389686
123Methylmalonic aciduria (HP:0012120)2.15875823
124Rib fusion (HP:0000902)2.14996392
125Rough bone trabeculation (HP:0100670)2.14759827
126Cholecystitis (HP:0001082)2.12748479
127Abnormal gallbladder physiology (HP:0012438)2.12748479
128Gaze-evoked nystagmus (HP:0000640)2.12736821
129Abnormality of serum amino acid levels (HP:0003112)2.12100432
130Abnormal respiratory epithelium morphology (HP:0012253)2.12024565
131Abnormal respiratory motile cilium morphology (HP:0005938)2.12024565
132Panhypogammaglobulinemia (HP:0003139)2.09226306
133Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08135597
134Oligomenorrhea (HP:0000876)2.07579648
135Exercise-induced muscle cramps (HP:0003710)2.06706046
136Nephrogenic diabetes insipidus (HP:0009806)2.05713229
137Renal cortical cysts (HP:0000803)2.05651831
138Sudden death (HP:0001699)2.03762324
139Broad-based gait (HP:0002136)2.02839501
140Fat malabsorption (HP:0002630)2.02748554
141Decreased central vision (HP:0007663)2.02259926
142Gliosis (HP:0002171)2.01889279
143Abnormal urine output (HP:0012590)2.01459475
144Brushfield spots (HP:0001088)1.97559765
145Abnormal biliary tract physiology (HP:0012439)1.97132037
146Bile duct proliferation (HP:0001408)1.97132037
147Abnormality of the common coagulation pathway (HP:0010990)1.96769716
148Respiratory difficulties (HP:0002880)1.95735478
149Tachypnea (HP:0002789)1.95425505
150Lissencephaly (HP:0001339)1.95185884
151Congenital sensorineural hearing impairment (HP:0008527)1.95184019
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93614185
153Pigmentary retinal degeneration (HP:0001146)1.92814180
154Vascular calcification (HP:0004934)1.91515524
155Increased corneal curvature (HP:0100692)1.91100578
156Keratoconus (HP:0000563)1.91100578
157Hyperphosphaturia (HP:0003109)1.91057860
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.90696414
159Nausea (HP:0002018)1.90630090
160Abnormality of DNA repair (HP:0003254)1.88736460
161Bulbous nose (HP:0000414)1.88546932
162Abnormal ciliary motility (HP:0012262)1.88417296
163Recurrent cutaneous fungal infections (HP:0011370)1.87825684
164Chronic mucocutaneous candidiasis (HP:0002728)1.87825684
165Absent speech (HP:0001344)1.86098240
166Furrowed tongue (HP:0000221)1.85507531
167Emotional lability (HP:0000712)1.85034089
168Widely spaced teeth (HP:0000687)1.84719299
169Abnormal albumin level (HP:0012116)1.84505184
170Hypoalbuminemia (HP:0003073)1.84505184
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.84004465
172Aplasia/Hypoplasia of the spleen (HP:0010451)1.83868189
173Tented upper lip vermilion (HP:0010804)1.83660621
174Bony spicule pigmentary retinopathy (HP:0007737)1.83455533
175Poor coordination (HP:0002370)1.83086248
176Ventricular tachycardia (HP:0004756)1.82556442
177Sclerocornea (HP:0000647)1.82431822
178Retinitis pigmentosa (HP:0000510)1.81894540
179Progressive external ophthalmoplegia (HP:0000590)1.81702332
180Cholelithiasis (HP:0001081)1.81356050
181Hypoplastic iliac wings (HP:0002866)1.80280536
182Hypoalphalipoproteinemia (HP:0003233)1.80172165
183Abnormal number of erythroid precursors (HP:0012131)1.78345404
184Increased serum pyruvate (HP:0003542)1.77390501
185Abnormality of glycolysis (HP:0004366)1.77390501
186Scotoma (HP:0000575)1.77170596
187Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75644597
188Abnormal rod and cone electroretinograms (HP:0008323)1.75600423
189Fair hair (HP:0002286)1.75584368
190Elevated erythrocyte sedimentation rate (HP:0003565)1.73828246
191Abnormality of renal excretion (HP:0011036)1.73702153
192Male pseudohermaphroditism (HP:0000037)1.73302216
193Atrial fibrillation (HP:0005110)1.73137179
194Genital tract atresia (HP:0001827)1.72669930
195Hypoplastic ischia (HP:0003175)1.70844717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.81772898
2FRK5.23160315
3RIPK42.99734432
4MAPK152.98472411
5ERN12.86145770
6BMPR1B2.85746160
7CCNB12.83329535
8ACVR1B2.67345189
9MKNK22.50642189
10PBK2.46601816
11NME12.41350881
12NME22.36809751
13BLK2.25837603
14SIK12.19561168
15TRIB32.11818110
16OBSCN2.02072097
17INSRR2.01284652
18WNK41.99945107
19MYLK1.98429378
20ZAK1.95549940
21STK391.85227488
22DAPK21.80814190
23MAP3K141.71613691
24MAPKAPK31.68382391
25MAP4K11.61875169
26BUB11.54571396
27MAPK131.53554813
28PHKG11.48285467
29PHKG21.48285467
30KIT1.47079486
31TXK1.44572520
32NUAK11.44307552
33CAMK1D1.41196918
34NEK11.40587865
35TLK11.38426953
36PINK11.35376699
37TYK21.34700875
38DAPK31.33872902
39TNK21.32487636
40PDK41.31109027
41PDK31.31109027
42JAK31.28632326
43BRAF1.25660953
44MAP2K61.24896701
45TBK11.23603415
46MAP4K21.18576992
47PKN21.17624725
48WNK31.13048280
49TAOK21.11802808
50TEC1.11676020
51TGFBR11.11369346
52STK38L1.10813109
53CAMKK11.09696202
54TTN1.09690922
55DYRK1B1.09655231
56YES11.07991852
57FGFR41.07602772
58IRAK11.07212738
59PRPF4B1.06703406
60GRK11.06118404
61WNK11.03717140
62MAPK71.02486361
63ZAP701.02070779
64IKBKB0.98054771
65FLT30.95707171
66CDK190.95474090
67PRKCQ0.95005709
68MAP2K30.94601659
69PIM20.93932781
70JAK20.93585806
71EIF2AK10.91501066
72RPS6KA60.90508088
73GRK60.90258268
74MAP3K70.89514678
75PIK3CA0.88542581
76IKBKE0.88263998
77MAPKAPK50.86852966
78TRPM70.86482162
79ADRBK20.82964028
80MAP3K120.82473566
81BTK0.82174672
82MAPK110.80464584
83CAMK1G0.80368352
84NLK0.79679284
85STK160.78504169
86MKNK10.78273112
87OXSR10.76049928
88LMTK20.75563363
89MAP3K50.75221695
90PDPK10.75071724
91PTK2B0.74916191
92NEK20.74135890
93AKT30.72829757
94TNIK0.72485891
95FGFR20.71803375
96DYRK30.71575482
97TTK0.70493579
98JAK10.70173609
99RPS6KA40.70049377
100TSSK60.68674027
101MAP3K40.67568763
102STK110.66845209
103CDC42BPA0.66640189
104HIPK20.65835837
105TAOK30.65136032
106CHUK0.64704071
107MUSK0.64679687
108TAOK10.62324890
109SRPK10.61513260
110IRAK30.61321054
111PIK3CG0.60384999
112PAK30.60243033
113PRKD20.60004425
114DYRK20.59278425
115ERBB20.58777659
116AKT20.58735603
117PDK10.58323190
118SIK20.58223388
119PRKAA10.58081262
120CAMK10.57157085
121ADRBK10.55994903
122EPHA30.54458564
123PKN10.52315081
124PRKACG0.51701815
125PRKACA0.50666176
126RPS6KA50.50563531
127CAMK2G0.50517190
128MAP3K110.50458768
129CAMK2D0.50290286
130CSF1R0.50211171
131PRKAA20.49796320
132DYRK1A0.49288473
133MELK0.48104772
134LCK0.47831205
135LYN0.47088640
136ILK0.47042750
137MAP2K40.46962373
138EEF2K0.46540946
139CAMKK20.45488667
140NTRK20.44786079
141MARK20.43483789
142FES0.43170745
143MAP2K20.41817068
144PRKCG0.41536554
145SYK0.41075412
146TYRO30.39895535
147ROCK10.39759890
148PASK0.39223609
149ITK0.38649539
150CASK0.38445018
151CAMK40.38041259
152PRKG10.37957255
153EIF2AK30.37462289
154HCK0.37169165
155PRKCI0.37102917
156PRKCH0.37094324
157RPS6KA20.37033797
158MAPK120.36798001
159VRK10.36042459
160PDK20.35553996
161CSK0.34338834
162MAPK40.33993846
163PRKCZ0.33285520
164PRKCA0.31967806
165RPS6KC10.31944406
166RPS6KL10.31944406

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.39888598
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.22969465
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.11898202
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.08138907
5Propanoate metabolism_Homo sapiens_hsa006402.99282139
6Linoleic acid metabolism_Homo sapiens_hsa005912.90073403
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81408555
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80539332
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.72058655
10Fatty acid degradation_Homo sapiens_hsa000712.63328920
11Oxidative phosphorylation_Homo sapiens_hsa001902.61891846
12Arginine biosynthesis_Homo sapiens_hsa002202.55477733
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.45696913
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.42691847
15Carbon metabolism_Homo sapiens_hsa012002.27499731
16Parkinsons disease_Homo sapiens_hsa050122.27006435
17Butanoate metabolism_Homo sapiens_hsa006502.17372431
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16564841
19Pyruvate metabolism_Homo sapiens_hsa006201.97129661
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96934612
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96477747
22Peroxisome_Homo sapiens_hsa041461.95371882
23Tryptophan metabolism_Homo sapiens_hsa003801.94250937
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92822506
25Biosynthesis of amino acids_Homo sapiens_hsa012301.90012788
26Fatty acid metabolism_Homo sapiens_hsa012121.86338049
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84164784
28Ether lipid metabolism_Homo sapiens_hsa005651.70073732
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65868311
30Nitrogen metabolism_Homo sapiens_hsa009101.62187166
31Alzheimers disease_Homo sapiens_hsa050101.58114911
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56059157
33Taste transduction_Homo sapiens_hsa047421.53041804
34Huntingtons disease_Homo sapiens_hsa050161.51868249
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48241909
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47960960
37Vitamin B6 metabolism_Homo sapiens_hsa007501.46340339
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45136387
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.43450183
40Phototransduction_Homo sapiens_hsa047441.43436150
41Fatty acid elongation_Homo sapiens_hsa000621.41708758
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37898426
43Folate biosynthesis_Homo sapiens_hsa007901.37681543
44Nicotine addiction_Homo sapiens_hsa050331.36125310
45Homologous recombination_Homo sapiens_hsa034401.36039936
46PPAR signaling pathway_Homo sapiens_hsa033201.35772609
47Selenocompound metabolism_Homo sapiens_hsa004501.31084236
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30863516
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30491314
50beta-Alanine metabolism_Homo sapiens_hsa004101.30085812
51Cardiac muscle contraction_Homo sapiens_hsa042601.28438273
52Phenylalanine metabolism_Homo sapiens_hsa003601.24714273
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21963385
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.21166635
55Complement and coagulation cascades_Homo sapiens_hsa046101.20105277
56Fanconi anemia pathway_Homo sapiens_hsa034601.17001015
57Arachidonic acid metabolism_Homo sapiens_hsa005901.16103650
58Graft-versus-host disease_Homo sapiens_hsa053321.16054635
59Dorso-ventral axis formation_Homo sapiens_hsa043201.14229372
60Protein export_Homo sapiens_hsa030601.14140503
61Sulfur metabolism_Homo sapiens_hsa009201.13224012
62Morphine addiction_Homo sapiens_hsa050321.12922073
63Tyrosine metabolism_Homo sapiens_hsa003501.10490500
64Autoimmune thyroid disease_Homo sapiens_hsa053201.10128321
65Arginine and proline metabolism_Homo sapiens_hsa003301.09031586
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08962585
67Pentose phosphate pathway_Homo sapiens_hsa000301.05810065
68Fructose and mannose metabolism_Homo sapiens_hsa000511.05188551
69Retinol metabolism_Homo sapiens_hsa008301.04581628
70Ribosome_Homo sapiens_hsa030101.03978267
71Fat digestion and absorption_Homo sapiens_hsa049751.02408009
72Sulfur relay system_Homo sapiens_hsa041221.00126415
73One carbon pool by folate_Homo sapiens_hsa006700.99451777
74Ovarian steroidogenesis_Homo sapiens_hsa049130.97080173
75Staphylococcus aureus infection_Homo sapiens_hsa051500.94523356
76Olfactory transduction_Homo sapiens_hsa047400.94197097
77Starch and sucrose metabolism_Homo sapiens_hsa005000.92881773
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90004910
79Proteasome_Homo sapiens_hsa030500.87211654
80ABC transporters_Homo sapiens_hsa020100.85235403
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84943605
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81882561
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.81080569
84Histidine metabolism_Homo sapiens_hsa003400.78649130
85Circadian entrainment_Homo sapiens_hsa047130.78219561
86Metabolic pathways_Homo sapiens_hsa011000.77070422
87Insulin secretion_Homo sapiens_hsa049110.76877655
88Calcium signaling pathway_Homo sapiens_hsa040200.76415231
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74624579
90Chemical carcinogenesis_Homo sapiens_hsa052040.71348237
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70676542
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70525505
93Galactose metabolism_Homo sapiens_hsa000520.68061449
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.67967146
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66427817
96Serotonergic synapse_Homo sapiens_hsa047260.66090810
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65513017
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64437322
99T cell receptor signaling pathway_Homo sapiens_hsa046600.64380830
100Regulation of autophagy_Homo sapiens_hsa041400.64246852
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.64190451
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.62100102
103Cocaine addiction_Homo sapiens_hsa050300.60133439
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59713592
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58631934
106Hematopoietic cell lineage_Homo sapiens_hsa046400.58186136
107Glycerolipid metabolism_Homo sapiens_hsa005610.57040053
108Glutamatergic synapse_Homo sapiens_hsa047240.57037699
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.56369600
110Cholinergic synapse_Homo sapiens_hsa047250.52505542
111Basal transcription factors_Homo sapiens_hsa030220.52436353
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52398099
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.52073526
114Bile secretion_Homo sapiens_hsa049760.50303698
115Salivary secretion_Homo sapiens_hsa049700.50230385
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.47410989
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46278932
118Caffeine metabolism_Homo sapiens_hsa002320.45976277
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44615796
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44378739
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.43725822
122Type I diabetes mellitus_Homo sapiens_hsa049400.42370182
123Vitamin digestion and absorption_Homo sapiens_hsa049770.41283442
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39579375
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38871590
126RNA degradation_Homo sapiens_hsa030180.36711230
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36274703
128Oxytocin signaling pathway_Homo sapiens_hsa049210.33948081
129Pyrimidine metabolism_Homo sapiens_hsa002400.33854678
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32941027
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32355335
132MAPK signaling pathway_Homo sapiens_hsa040100.32332722
133GABAergic synapse_Homo sapiens_hsa047270.32296514
134Antigen processing and presentation_Homo sapiens_hsa046120.29714406
135Insulin resistance_Homo sapiens_hsa049310.29388616
136Basal cell carcinoma_Homo sapiens_hsa052170.27890446
137cAMP signaling pathway_Homo sapiens_hsa040240.27145537
138Lysine degradation_Homo sapiens_hsa003100.26761787
139RNA polymerase_Homo sapiens_hsa030200.25815768
140Asthma_Homo sapiens_hsa053100.24739722
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24186033
142Glutathione metabolism_Homo sapiens_hsa004800.23123805
143Allograft rejection_Homo sapiens_hsa053300.22923933
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.21394875
145Glucagon signaling pathway_Homo sapiens_hsa049220.17178678
146AMPK signaling pathway_Homo sapiens_hsa041520.16891277
147Primary immunodeficiency_Homo sapiens_hsa053400.10803928
148Prion diseases_Homo sapiens_hsa050200.07421162
149Purine metabolism_Homo sapiens_hsa002300.06100814
150Fatty acid biosynthesis_Homo sapiens_hsa000610.05095700
151Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04489227
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.03600131
153Type II diabetes mellitus_Homo sapiens_hsa049300.02536247
154Insulin signaling pathway_Homo sapiens_hsa049100.01923646

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