HEPACAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)8.02300400
2protein maturation by protein folding (GO:0022417)7.16602642
3peptide hormone processing (GO:0016486)6.86373610
4signal peptide processing (GO:0006465)6.68380961
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.60911016
6regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.53856229
7glandular epithelial cell differentiation (GO:0002067)6.46491304
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.34954947
9COPII vesicle coating (GO:0048208)6.21253574
10regulation of type B pancreatic cell apoptotic process (GO:2000674)6.17072196
11sequestering of metal ion (GO:0051238)6.16118268
12protein retention in ER lumen (GO:0006621)5.67139843
13positive regulation of insulin secretion (GO:0032024)5.42110112
14insulin secretion (GO:0030073)5.31201237
15exocrine pancreas development (GO:0031017)5.23313252
16type B pancreatic cell development (GO:0003323)5.19401625
17glandular epithelial cell development (GO:0002068)5.01219466
18cellular ketone body metabolic process (GO:0046950)4.94465936
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.91957845
20ER overload response (GO:0006983)4.81109250
21regulation of insulin secretion (GO:0050796)4.79288186
22positive regulation of nuclease activity (GO:0032075)4.67531661
23auditory receptor cell differentiation (GO:0042491)4.52242767
24vesicle coating (GO:0006901)4.47739268
25phenylpropanoid metabolic process (GO:0009698)4.46858990
26regulation of peptide hormone secretion (GO:0090276)4.40772445
27glycerophospholipid catabolic process (GO:0046475)4.38354872
28positive regulation of peptide hormone secretion (GO:0090277)4.38301341
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.36066636
30ketone body metabolic process (GO:1902224)4.35064791
31positive regulation of response to nutrient levels (GO:0032109)4.32994458
32positive regulation of response to extracellular stimulus (GO:0032106)4.32994458
33regulation of peptide secretion (GO:0002791)4.32804633
34regulation of nuclease activity (GO:0032069)4.28537565
35adult feeding behavior (GO:0008343)4.24918277
36positive regulation of peptide secretion (GO:0002793)4.21492343
37negative regulation of glycoprotein biosynthetic process (GO:0010561)4.20143536
38endoplasmic reticulum unfolded protein response (GO:0030968)4.17353448
39columnar/cuboidal epithelial cell development (GO:0002066)4.14676563
40cellular response to unfolded protein (GO:0034620)4.13724316
41cellular response to topologically incorrect protein (GO:0035967)4.09085684
42negative regulation of norepinephrine secretion (GO:0010700)4.00640405
43nitric oxide mediated signal transduction (GO:0007263)3.99656677
44cellular response to vitamin D (GO:0071305)3.97036934
45inositol phosphate catabolic process (GO:0071545)3.92629337
46ER-nucleus signaling pathway (GO:0006984)3.90438775
47detection of calcium ion (GO:0005513)3.89654452
48negative regulation of insulin secretion (GO:0046676)3.87449321
49regulation of hormone secretion (GO:0046883)3.87093785
50peptide hormone secretion (GO:0030072)3.86028713
51phosphorylated carbohydrate dephosphorylation (GO:0046838)3.82295363
52inositol phosphate dephosphorylation (GO:0046855)3.82295363
53negative regulation of hormone biosynthetic process (GO:0032353)3.81158589
54protein N-linked glycosylation via asparagine (GO:0018279)3.80333237
55cellular zinc ion homeostasis (GO:0006882)3.77944761
56peptide secretion (GO:0002790)3.77666814
57peptidyl-asparagine modification (GO:0018196)3.77382021
58intra-Golgi vesicle-mediated transport (GO:0006891)3.72386437
59negative regulation of gluconeogenesis (GO:0045721)3.67730554
60negative regulation of catecholamine secretion (GO:0033604)3.67278411
61regulation of hexokinase activity (GO:1903299)3.64124568
62regulation of glucokinase activity (GO:0033131)3.64124568
63toxin metabolic process (GO:0009404)3.59520752
64regulation of peptide transport (GO:0090087)3.58812690
65negative regulation of hormone metabolic process (GO:0032351)3.55263679
66epithelial cell fate commitment (GO:0072148)3.54957552
67ER to Golgi vesicle-mediated transport (GO:0006888)3.53825477
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.50857564
693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.50857564
70positive regulation of hormone secretion (GO:0046887)3.50152068
71negative regulation of bone resorption (GO:0045779)3.50103070
72protein N-linked glycosylation (GO:0006487)3.46913770
73response to endoplasmic reticulum stress (GO:0034976)3.45525883
74regulation of glucocorticoid secretion (GO:2000849)3.42330893
75regulation of protein glycosylation (GO:0060049)3.41360883
76positive regulation of growth hormone secretion (GO:0060124)3.38368798
77regulation of oxidative phosphorylation (GO:0002082)3.37277469
78negative regulation of peptide hormone secretion (GO:0090278)3.36182821
79nucleoside diphosphate catabolic process (GO:0009134)3.36169058
80GDP-mannose metabolic process (GO:0019673)3.34233907
81positive regulation of macroautophagy (GO:0016239)3.32589060
82negative regulation of peptide secretion (GO:0002792)3.28185783
83response to hexose (GO:0009746)3.26656467
84cellular response to hepatocyte growth factor stimulus (GO:0035729)3.24426083
85response to hepatocyte growth factor (GO:0035728)3.24426083
86negative regulation of glycoprotein metabolic process (GO:1903019)3.21356973
87response to glucose (GO:0009749)3.20721776
88intestinal epithelial cell development (GO:0060576)3.18940201
89polyol catabolic process (GO:0046174)3.17303493
90protein localization to Golgi apparatus (GO:0034067)3.17234973
91growth hormone secretion (GO:0030252)3.17223920
92response to unfolded protein (GO:0006986)3.16823272
93lactate metabolic process (GO:0006089)3.15974205
94peptide transport (GO:0015833)3.15662917
95signal transduction involved in regulation of gene expression (GO:0023019)3.15470873
96astrocyte differentiation (GO:0048708)3.14574330
97positive regulation of respiratory burst (GO:0060267)3.14461464
98L-alpha-amino acid transmembrane transport (GO:1902475)3.14400642
99eosinophil chemotaxis (GO:0048245)3.13163156
100hormone secretion (GO:0046879)3.12425912
101positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.12337869
102response to topologically incorrect protein (GO:0035966)3.11825932
103xenobiotic catabolic process (GO:0042178)3.10713864
104response to monosaccharide (GO:0034284)3.09340450
105positive regulation of glycolytic process (GO:0045821)3.04746877
106angiotensin maturation (GO:0002003)3.04615591
107macroautophagy (GO:0016236)3.04268636
108carbohydrate homeostasis (GO:0033500)3.02993610
109glucose homeostasis (GO:0042593)3.02993610
110regulation of autophagic vacuole assembly (GO:2000785)3.02597785
111fucose catabolic process (GO:0019317)2.97576701
112L-fucose metabolic process (GO:0042354)2.97576701
113L-fucose catabolic process (GO:0042355)2.97576701
114neuron fate specification (GO:0048665)2.97454928
115dentate gyrus development (GO:0021542)2.96504120
116interleukin-1-mediated signaling pathway (GO:0070498)2.95843362
117magnesium ion transport (GO:0015693)2.95058898
118hormone transport (GO:0009914)2.94876375
119water-soluble vitamin biosynthetic process (GO:0042364)2.93462126
120regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.91471665
121response to pheromone (GO:0019236)2.91159710
122negative regulation of protein oligomerization (GO:0032460)2.90799030
123Golgi vesicle transport (GO:0048193)2.89305903
124respiratory chain complex IV assembly (GO:0008535)2.88842999
125intestinal absorption (GO:0050892)2.88372852
126Golgi organization (GO:0007030)2.87306218
127zinc ion homeostasis (GO:0055069)2.86991796
128negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.86614852
129columnar/cuboidal epithelial cell differentiation (GO:0002065)2.86176089
130digestion (GO:0007586)2.85818065
131regulation of energy homeostasis (GO:2000505)2.84446072
132sphingomyelin metabolic process (GO:0006684)2.82618165
133nodal signaling pathway (GO:0038092)2.81348958
134brain morphogenesis (GO:0048854)2.79118510
135positive regulation of actin filament depolymerization (GO:0030836)2.79011938
136zinc ion transmembrane transport (GO:0071577)2.76531137
137positive regulation of calcium ion import (GO:0090280)2.74569776
138zinc ion transport (GO:0006829)2.74461995
139amide transport (GO:0042886)2.74055229
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71694057
141L-phenylalanine catabolic process (GO:0006559)2.71694057
142cytochrome complex assembly (GO:0017004)2.71223715
143regulation of vacuole organization (GO:0044088)2.70289831
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69839165
145L-phenylalanine metabolic process (GO:0006558)2.69839165
146negative regulation of execution phase of apoptosis (GO:1900118)2.67991159
147oligosaccharide catabolic process (GO:0009313)2.66457994
148regulation of bile acid biosynthetic process (GO:0070857)2.65964366
149retinol metabolic process (GO:0042572)2.64866503
150Golgi to endosome transport (GO:0006895)2.64307112
151membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63834895
152nitric oxide biosynthetic process (GO:0006809)2.62176134
153chemosensory behavior (GO:0007635)2.60722815
154phospholipid dephosphorylation (GO:0046839)2.60610199
155epoxygenase P450 pathway (GO:0019373)2.58104301
156phospholipid catabolic process (GO:0009395)2.50783283
157kidney morphogenesis (GO:0060993)2.50563236
158somite rostral/caudal axis specification (GO:0032525)2.49045148
159positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47775466
160COPI coating of Golgi vesicle (GO:0048205)10.3963018
161Golgi transport vesicle coating (GO:0048200)10.3963018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.62849146
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.51133773
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.11591263
4GATA1_22025678_ChIP-Seq_K562_Human3.38331885
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36501197
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28697414
7CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97266411
8ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97080372
9* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95940270
10IGF1R_20145208_ChIP-Seq_DFB_Human1.95207093
11SOX2_27498859_Chip-Seq_STOMACH_Mouse1.87519857
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74813965
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73125047
14NR3C1_23031785_ChIP-Seq_PC12_Mouse1.71409748
15HTT_18923047_ChIP-ChIP_STHdh_Human1.68190655
16OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.66434205
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64737846
18* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64163863
19REST_21632747_ChIP-Seq_MESCs_Mouse1.63839888
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62912347
21MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62245228
22VDR_22108803_ChIP-Seq_LS180_Human1.61832126
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61678937
24TFEB_21752829_ChIP-Seq_HELA_Human1.53563697
25CDX2_22108803_ChIP-Seq_LS180_Human1.53035101
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.52705231
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46367705
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45284554
29REST_19997604_ChIP-ChIP_NEURONS_Mouse1.45230218
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44574736
31AR_25329375_ChIP-Seq_VCAP_Human1.43465128
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42975630
33P300_19829295_ChIP-Seq_ESCs_Human1.42508635
34ER_23166858_ChIP-Seq_MCF-7_Human1.39845857
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38537681
36ERG_20517297_ChIP-Seq_VCAP_Human1.36643500
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.35999141
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.35302787
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32124789
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31431874
41FUS_26573619_Chip-Seq_HEK293_Human1.31204072
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.31179522
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31177715
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30422496
45* FOXA1_25552417_ChIP-Seq_VCAP_Human1.30278602
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25822122
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25126713
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23903481
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.23628532
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22783992
51STAT3_23295773_ChIP-Seq_U87_Human1.22514690
52GBX2_23144817_ChIP-Seq_PC3_Human1.22269514
53TCF4_22108803_ChIP-Seq_LS180_Human1.22256245
54TAF15_26573619_Chip-Seq_HEK293_Human1.22137884
55ZNF274_21170338_ChIP-Seq_K562_Hela1.21589882
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.21019519
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20923182
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20424731
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19182927
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.18896867
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18601450
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18242123
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18222415
64TP53_22573176_ChIP-Seq_HFKS_Human1.17787494
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17659205
66TCF4_23295773_ChIP-Seq_U87_Human1.16742134
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16282037
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15527825
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.14451150
70FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14191440
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13964085
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13833826
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13591910
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13578945
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13507740
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.13475307
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.11752095
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.11364687
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.11287569
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10928339
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10514427
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10433939
83* PIAS1_25552417_ChIP-Seq_VCAP_Human1.10344507
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.10079757
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10015056
86SOX2_20726797_ChIP-Seq_SW620_Human1.09369065
87TBL1_22424771_ChIP-Seq_293T_Human1.08870694
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06933381
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06719572
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.05468121
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.05331570
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04854732
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04718757
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04276928
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03924500
96P300_18555785_Chip-Seq_ESCs_Mouse1.03231603
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03137430
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02877908
99PHF8_20622853_ChIP-Seq_HELA_Human1.02109942
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01566752
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01516665
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01114242
103NANOG_19829295_ChIP-Seq_ESCs_Human1.00369705
104SOX2_19829295_ChIP-Seq_ESCs_Human1.00369705
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00156854
106GF1B_26923725_Chip-Seq_HPCs_Mouse1.00093071
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99878843
108CBP_20019798_ChIP-Seq_JUKART_Human0.99878843
109HNFA_21074721_ChIP-Seq_CACO-2_Human0.99756222
110STAT3_18555785_Chip-Seq_ESCs_Mouse0.99619772
111PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99581416
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.99243602
113NFYB_21822215_ChIP-Seq_K562_Human0.98239360
114NMYC_18555785_Chip-Seq_ESCs_Mouse0.97651902
115* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96704152
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96478232
117NCOR_22424771_ChIP-Seq_293T_Human0.96453744
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.96002992
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.94355354
120FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93128688
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93118804
122AR_20517297_ChIP-Seq_VCAP_Human0.92734570
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92619841
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92145063
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.91688566
126* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91102943
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89758845
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89500354
129* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89474724
130GATA4_25053715_ChIP-Seq_YYC3_Human0.88722725
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88037804
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87965441
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.87965441
134GATA3_27048872_Chip-Seq_THYMUS_Human0.86973212
135* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86557270
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86332188
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86207962
138P53_22387025_ChIP-Seq_ESCs_Mouse0.85092388
139BCAT_22108803_ChIP-Seq_LS180_Human0.84519302
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83120278
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82524937
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81513765
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81313421
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81269008
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.80717969
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80476585
147DROSHA_22980978_ChIP-Seq_HELA_Human0.79157261
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79049645
149SMAD4_21799915_ChIP-Seq_A2780_Human0.78820214
150GF1_26923725_Chip-Seq_HPCs_Mouse0.78296218
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78125160
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78078121
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77993747
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77602307
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.77470059
156* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77282086
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76578248
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.76561186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.67228849
2MP0003283_abnormal_digestive_organ4.70978333
3MP0002693_abnormal_pancreas_physiology4.37653015
4MP0004043_abnormal_pH_regulation4.36710944
5MP0010386_abnormal_urinary_bladder3.98631789
6MP0000013_abnormal_adipose_tissue3.96222686
7MP0003183_abnormal_peptide_metabolism3.92414008
8MP0005379_endocrine/exocrine_gland_phen3.92224069
9MP0010234_abnormal_vibrissa_follicle3.86495329
10MP0009780_abnormal_chondrocyte_physiolo3.83855167
11MP0001944_abnormal_pancreas_morphology3.83762362
12MP0002909_abnormal_adrenal_gland3.47202047
13MP0003195_calcinosis3.45653894
14MP0000678_abnormal_parathyroid_gland3.41774861
15MP0005220_abnormal_exocrine_pancreas3.01047972
16MP0002837_dystrophic_cardiac_calcinosis2.58413587
17MP0004019_abnormal_vitamin_homeostasis2.53958540
18MP0001986_abnormal_taste_sensitivity2.47941117
19MP0002078_abnormal_glucose_homeostasis2.30144464
20MP0002163_abnormal_gland_morphology2.25273162
21MP0004264_abnormal_extraembryonic_tissu2.22893349
22MP0006072_abnormal_retinal_apoptosis2.21441016
23MP0000003_abnormal_adipose_tissue2.05724444
24MP0010329_abnormal_lipoprotein_level2.03277938
25MP0005646_abnormal_pituitary_gland2.01892022
26MP0000462_abnormal_digestive_system1.99269912
27MP0005645_abnormal_hypothalamus_physiol1.92490496
28MP0003300_gastrointestinal_ulcer1.92070656
29MP0003172_abnormal_lysosome_physiology1.86437526
30MP0002928_abnormal_bile_duct1.83772527
31MP0005085_abnormal_gallbladder_physiolo1.78051266
32MP0002638_abnormal_pupillary_reflex1.75238562
33MP0008877_abnormal_DNA_methylation1.71643442
34MP0005332_abnormal_amino_acid1.71444059
35MP0001765_abnormal_ion_homeostasis1.63371729
36MP0005257_abnormal_intraocular_pressure1.59454807
37MP0003123_paternal_imprinting1.59171626
38MP0000613_abnormal_salivary_gland1.55192163
39MP0001501_abnormal_sleep_pattern1.50950032
40MP0004147_increased_porphyrin_level1.44803561
41MP0002138_abnormal_hepatobiliary_system1.44317342
42MP0003953_abnormal_hormone_level1.39959167
43MP0003868_abnormal_feces_composition1.39261024
44MP0005310_abnormal_salivary_gland1.37167350
45MP0002896_abnormal_bone_mineralization1.36658257
46MP0009643_abnormal_urine_homeostasis1.36196479
47MP0008961_abnormal_basal_metabolism1.34514647
48MP0005360_urolithiasis1.34027858
49MP0002876_abnormal_thyroid_physiology1.26973518
50MP0009046_muscle_twitch1.25747468
51MP0010352_gastrointestinal_tract_polyps1.25611954
52MP0002234_abnormal_pharynx_morphology1.24045595
53MP0004924_abnormal_behavior1.18277855
54MP0005386_behavior/neurological_phenoty1.18277855
55MP0005551_abnormal_eye_electrophysiolog1.17519946
56MP0002272_abnormal_nervous_system1.17270250
57MP0005535_abnormal_body_temperature1.16884727
58MP0002822_catalepsy1.14828939
59MP0003866_abnormal_defecation1.14263900
60MP0005636_abnormal_mineral_homeostasis1.10268283
61MP0002277_abnormal_respiratory_mucosa1.08243560
62MP0003252_abnormal_bile_duct1.07778537
63MP0001905_abnormal_dopamine_level1.07612696
64MP0005058_abnormal_lysosome_morphology1.06966759
65MP0001756_abnormal_urination1.05690754
66MP0003122_maternal_imprinting1.05044034
67MP0003121_genomic_imprinting1.04623637
68MP0000538_abnormal_urinary_bladder1.04598481
69MP0004133_heterotaxia1.01939136
70MP0000631_abnormal_neuroendocrine_gland1.01808445
71MP0001666_abnormal_nutrient_absorption1.01035847
72MP0001270_distended_abdomen0.99442910
73MP0000427_abnormal_hair_cycle0.98392417
74MP0002139_abnormal_hepatobiliary_system0.96816253
75MP0004270_analgesia0.95643457
76MP0003959_abnormal_lean_body0.94669721
77MP0008872_abnormal_physiological_respon0.93542639
78MP0001485_abnormal_pinna_reflex0.90476466
79MP0005365_abnormal_bile_salt0.89501976
80MP0010678_abnormal_skin_adnexa0.89071927
81MP0005448_abnormal_energy_balance0.88348901
82MP0006036_abnormal_mitochondrial_physio0.87771049
83MP0005375_adipose_tissue_phenotype0.85439197
84MP0000681_abnormal_thyroid_gland0.85177314
85MP0005408_hypopigmentation0.84512184
86MP0001984_abnormal_olfaction0.84393672
87MP0003879_abnormal_hair_cell0.83738052
88MP0002557_abnormal_social/conspecific_i0.83539950
89MP0003119_abnormal_digestive_system0.82962402
90MP0006054_spinal_hemorrhage0.82165144
91MP0002064_seizures0.82002646
92MP0009745_abnormal_behavioral_response0.80633232
93MP0001186_pigmentation_phenotype0.79419875
94MP0003633_abnormal_nervous_system0.79209980
95MP0001502_abnormal_circadian_rhythm0.78693774
96MP0000230_abnormal_systemic_arterial0.77308084
97MP0003011_delayed_dark_adaptation0.76801509
98MP0003890_abnormal_embryonic-extraembry0.76588163
99MP0001764_abnormal_homeostasis0.76137785
100MP0001970_abnormal_pain_threshold0.75853338
101MP0006292_abnormal_olfactory_placode0.73325819
102MP0002229_neurodegeneration0.72702080
103MP0005253_abnormal_eye_physiology0.72588487
104MP0001299_abnormal_eye_distance/0.71305945
105MP0002971_abnormal_brown_adipose0.70983666
106MP0001346_abnormal_lacrimal_gland0.69459976
107MP0002938_white_spotting0.69432615
108MP0005670_abnormal_white_adipose0.68930687
109MP0001664_abnormal_digestion0.68924517
110MP0000371_diluted_coat_color0.68665538
111MP0008775_abnormal_heart_ventricle0.65903015
112MP0005266_abnormal_metabolism0.65796092
113MP0002166_altered_tumor_susceptibility0.65773273
114MP0000516_abnormal_urinary_system0.65053292
115MP0002653_abnormal_ependyma_morphology0.63314626
116MP0002751_abnormal_autonomic_nervous0.63268831
117MP0003795_abnormal_bone_structure0.59254068
118MP0000569_abnormal_digit_pigmentation0.58959185
119MP0000566_synostosis0.58860531
120MP0003787_abnormal_imprinting0.58505483
121MP0002177_abnormal_outer_ear0.57496818
122MP0000639_abnormal_adrenal_gland0.57433986
123MP0002118_abnormal_lipid_homeostasis0.55834010
124MP0005084_abnormal_gallbladder_morpholo0.54985638
125MP0009642_abnormal_blood_homeostasis0.53677756
126MP0001661_extended_life_span0.53536183
127MP0005334_abnormal_fat_pad0.53189900
128MP0002733_abnormal_thermal_nociception0.53037770
129MP0001919_abnormal_reproductive_system0.51845871
130MP0002734_abnormal_mechanical_nocicepti0.50187318
131MP0003045_fibrosis0.49651210
132MP0009672_abnormal_birth_weight0.48138866
133MP0002168_other_aberrant_phenotype0.46695199
134MP0002069_abnormal_eating/drinking_beha0.45681239
135MP0005452_abnormal_adipose_tissue0.44152811
136MP0000163_abnormal_cartilage_morphology0.44131638
137MP0004885_abnormal_endolymph0.42014380
138MP0000470_abnormal_stomach_morphology0.41423765
139MP0002098_abnormal_vibrissa_morphology0.40578106
140MP0004782_abnormal_surfactant_physiolog0.40216363

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.85587717
2Hypoglycemic seizures (HP:0002173)7.38176034
3Symptomatic seizures (HP:0011145)7.17923441
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.88788158
5Hypoglycemic coma (HP:0001325)6.41034798
6Insulin-resistant diabetes mellitus (HP:0000831)4.94181674
7Hyperglycemia (HP:0003074)4.80789791
8Abnormality of calcium-phosphate metabolism (HP:0100530)4.71022538
9Decreased circulating renin level (HP:0003351)4.69968211
10Abnormality of endocrine pancreas physiology (HP:0012093)4.39192832
11Abnormality of the pancreatic islet cells (HP:0006476)4.39192832
12Ketoacidosis (HP:0001993)4.36974499
13Abnormal pancreas size (HP:0012094)4.32428829
14Late onset (HP:0003584)4.26897563
15Generalized aminoaciduria (HP:0002909)4.16784925
16Large for gestational age (HP:0001520)3.98930675
17Osteomalacia (HP:0002749)3.93538858
18Pancreatic islet-cell hyperplasia (HP:0004510)3.93129050
19Hypokalemia (HP:0002900)3.79713976
20Urinary glycosaminoglycan excretion (HP:0003541)3.72914827
21Mucopolysacchariduria (HP:0008155)3.72914827
22Abnormality of vitamin B metabolism (HP:0004340)3.65652579
23Dysostosis multiplex (HP:0000943)3.49622234
24Abnormality of polysaccharide metabolism (HP:0011012)3.47829936
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.47829936
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.47829936
27Hyperactive renin-angiotensin system (HP:0000841)3.43900526
28Hyperparathyroidism (HP:0000843)3.38201510
29Hypomagnesemia (HP:0002917)3.31636170
30Abnormality of renin-angiotensin system (HP:0000847)3.19389303
31Hypothermia (HP:0002045)3.17591389
32Conjugated hyperbilirubinemia (HP:0002908)3.12018694
33Double outlet right ventricle (HP:0001719)3.09747743
34Congenital malformation of the right heart (HP:0011723)3.09747743
35Enlarged penis (HP:0000040)3.05025721
36Abnormality of the intrinsic pathway (HP:0010989)3.02763394
37Abnormality of magnesium homeostasis (HP:0004921)3.00989592
38Abnormality of potassium homeostasis (HP:0011042)2.97968419
39Insulin resistance (HP:0000855)2.97716203
40Abnormality of vitamin metabolism (HP:0100508)2.91849377
41Abnormality of chloride homeostasis (HP:0011422)2.88750424
42Proximal tubulopathy (HP:0000114)2.73480214
43Hyperkalemia (HP:0002153)2.70960575
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.70955005
45Hypoplasia of the fovea (HP:0007750)2.70955005
46Prominent metopic ridge (HP:0005487)2.70691971
47Limb hypertonia (HP:0002509)2.67635334
48Exocrine pancreatic insufficiency (HP:0001738)2.66277703
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62718440
50Unilateral renal agenesis (HP:0000122)2.56773423
51Chronic bronchitis (HP:0004469)2.53015244
52Hyperthyroidism (HP:0000836)2.52672805
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.50463629
54Abnormality of the fovea (HP:0000493)2.49228581
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48943229
56Abdominal distention (HP:0003270)2.47328753
57Agitation (HP:0000713)2.47149315
58Abnormal protein glycosylation (HP:0012346)2.37454249
59Abnormal glycosylation (HP:0012345)2.37454249
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37454249
61Abnormal protein N-linked glycosylation (HP:0012347)2.37454249
62Metabolic alkalosis (HP:0200114)2.37177857
63Malnutrition (HP:0004395)2.35595449
64Fat malabsorption (HP:0002630)2.35463977
65Intestinal atresia (HP:0011100)2.34257891
66Abnormality of the metopic suture (HP:0005556)2.32952824
67Ketosis (HP:0001946)2.31788902
68Dysautonomia (HP:0002459)2.31739300
69Cortical visual impairment (HP:0100704)2.29178868
70Progressive neurologic deterioration (HP:0002344)2.28984251
71Hypokalemic alkalosis (HP:0001949)2.26494626
72Hepatic necrosis (HP:0002605)2.25693680
73Increased CSF protein (HP:0002922)2.25146032
74Vacuolated lymphocytes (HP:0001922)2.24319932
75Medial flaring of the eyebrow (HP:0010747)2.24008097
76Thoracolumbar scoliosis (HP:0002944)2.22407193
77Retinal atrophy (HP:0001105)2.21385620
78Hyperphosphatemia (HP:0002905)2.20794644
79Type I transferrin isoform profile (HP:0003642)2.20089103
80Abnormality of the renal cortex (HP:0011035)2.19749860
81Hypophosphatemia (HP:0002148)2.19737706
82Dicarboxylic aciduria (HP:0003215)2.16535229
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16535229
84Steatorrhea (HP:0002570)2.15523283
85Hypokinesia (HP:0002375)2.15025311
86Hyperaldosteronism (HP:0000859)2.14900971
87Hyperphosphaturia (HP:0003109)2.14480912
88EEG with generalized epileptiform discharges (HP:0011198)2.14440078
89Xanthomatosis (HP:0000991)2.14243014
90Syncope (HP:0001279)2.12615773
91Hemiparesis (HP:0001269)2.11772056
92Hydroxyprolinuria (HP:0003080)2.11279296
93Abnormality of proline metabolism (HP:0010907)2.11279296
94Methylmalonic acidemia (HP:0002912)2.10222601
95Gout (HP:0001997)2.09747667
96Abnormality of liposaccharide metabolism (HP:0010968)2.09728668
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.09728668
98Abnormality of glycolipid metabolism (HP:0010969)2.09728668
99Hypsarrhythmia (HP:0002521)2.08490290
100Testicular neoplasm (HP:0010788)2.08326924
101Hypotension (HP:0002615)2.07034641
102Conjunctival hamartoma (HP:0100780)2.06464882
103Polyphagia (HP:0002591)2.06201239
104Abnormal drinking behavior (HP:0030082)2.05612955
105Polydipsia (HP:0001959)2.05612955
106Hypobetalipoproteinemia (HP:0003563)2.04961444
107Renal cortical cysts (HP:0000803)2.04846997
108Epileptiform EEG discharges (HP:0011182)2.03598590
109Hypoalbuminemia (HP:0003073)2.01315853
110Abnormal albumin level (HP:0012116)2.01315853
111Pheochromocytoma (HP:0002666)2.00867789
112Hamartoma of the eye (HP:0010568)2.00543751
113Abnormality of urine glucose concentration (HP:0011016)2.00261389
114Glycosuria (HP:0003076)2.00261389
115Protuberant abdomen (HP:0001538)1.99979807
116Sex reversal (HP:0012245)1.99666477
117Abnormal sex determination (HP:0012244)1.99666477
118Villous atrophy (HP:0011473)1.97494299
119Abnormality of small intestinal villus morphology (HP:0011472)1.97494299
120Methylmalonic aciduria (HP:0012120)1.96633463
121Hematochezia (HP:0002573)1.96390198
122Adrenal overactivity (HP:0002717)1.96051610
123Tongue fasciculations (HP:0001308)1.91316558
124Attenuation of retinal blood vessels (HP:0007843)1.90385664
125Muscular hypotonia of the trunk (HP:0008936)1.90174227
126Postural tremor (HP:0002174)1.87371061
127Visual hallucinations (HP:0002367)1.86973655
128Ventricular fibrillation (HP:0001663)1.84974371
129Abnormality of renal excretion (HP:0011036)1.84634426
130Prolonged partial thromboplastin time (HP:0003645)1.84177858
131Disproportionate short-trunk short stature (HP:0003521)1.83106688
132Menstrual irregularities (HP:0000858)1.82890797
133Macroorchidism (HP:0000053)1.82215728
134Abnormal biliary tract morphology (HP:0012440)1.81379065
135Hypoplastic labia majora (HP:0000059)1.78943052
136Increased circulating renin level (HP:0000848)1.77287066
137Vascular calcification (HP:0004934)1.77250919
138Hypercortisolism (HP:0001578)1.77202249
139Abnormal rod and cone electroretinograms (HP:0008323)1.77196121
140Congenital sensorineural hearing impairment (HP:0008527)1.76033419
141Abnormal urine phosphate concentration (HP:0012599)1.75455509
142Congenital glaucoma (HP:0001087)1.73834181
143Elevated alkaline phosphatase (HP:0003155)1.72849608
144Irregular vertebral endplates (HP:0003301)1.72621745
145Hepatoblastoma (HP:0002884)1.72146066
146Bony spicule pigmentary retinopathy (HP:0007737)1.72080395
147Cystic liver disease (HP:0006706)1.70269683
148Abnormality of purine metabolism (HP:0004352)1.69476527
149Alkalosis (HP:0001948)1.66740468
150Abnormality of alkaline phosphatase activity (HP:0004379)1.65284349
151Abnormality of the right ventricle (HP:0001707)1.63440663
152Absent eyebrow (HP:0002223)1.63284658
153Neuroendocrine neoplasm (HP:0100634)1.61671489
154Aplasia/Hypoplasia of the macula (HP:0008059)1.61174620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.94359644
2PASK6.08086111
3MAPK154.27341010
4FGFR23.57062055
5PRKD33.54677135
6FRK3.37300180
7HIPK23.05979362
8TAOK32.98843565
9ACVR1B2.96375224
10MAP3K22.74972918
11MAP2K62.47583746
12MST42.41395560
13MAP3K42.37633311
14ERN12.32294814
15PHKG22.19988197
16PHKG12.19988197
17IRAK32.11047202
18GRK12.03868973
19FLT31.91885912
20WNK41.88484674
21STK241.87300780
22CASK1.80723428
23DAPK21.80352247
24PINK11.78717459
25WNK31.76777600
26ADRBK21.73665160
27IRAK21.70529437
28IRAK11.64047630
29EIF2AK11.63846620
30TRPM71.39179704
31CDC42BPA1.39046365
32MAP3K91.35196160
33STK31.31825363
34LMTK21.29193965
35PDGFRA1.29010753
36PRKD21.26791949
37STK38L1.25203092
38TAOK11.23852523
39NTRK11.23678259
40EPHA31.23033336
41UHMK11.18375476
42MAP3K11.13618949
43CSNK1G11.13165437
44IRAK41.12193079
45EIF2AK31.12073354
46CAMKK21.11834540
47PRKCH1.11655768
48DYRK1B1.11411417
49BRSK21.07732660
50PTK61.07245717
51AKT31.06996385
52MAP4K21.05307878
53ITK1.03039162
54OXSR11.01082156
55STK390.98493215
56PTK20.97925840
57NTRK30.96500885
58CSNK1G30.96434674
59PTK2B0.96387853
60PIK3CG0.91869939
61PAK30.91660195
62MAP2K20.91536315
63SCYL20.90585496
64BMPR20.89903090
65TNIK0.87135800
66STK160.85933110
67CSNK1G20.85749774
68ERBB30.85467536
69PRKG20.84645465
70BRD40.82345502
71PRKCG0.77214573
72MET0.76760322
73MAP3K30.75622756
74FGFR40.74953776
75NLK0.74659510
76YES10.72892263
77STK40.72174322
78PRKCE0.71753375
79PIK3CA0.70686979
80STK110.70247713
81BMPR1B0.63543859
82PRKCI0.62991336
83TEC0.61999334
84BRAF0.61847525
85NEK60.59353709
86CHUK0.58181957
87BRSK10.57763252
88MAP3K120.57127657
89FER0.55025604
90PRKAA10.52433358
91MAP2K70.52278782
92BCKDK0.52267552
93CSNK1A1L0.52248445
94RPS6KA20.51591215
95SIK30.49920022
96FGFR30.47760853
97BCR0.46576422
98MAPK110.46543099
99SGK20.45393034
100SIK10.44733454
101JAK30.43253507
102PNCK0.42362802
103CAMK2A0.41781173
104STK380.41425537
105CAMK2D0.41368643
106VRK10.41322424
107PRKCZ0.41255620
108WNK10.40728529
109JAK20.40577279
110PLK20.40495548
111JAK10.38819679
112SGK10.38349667
113TESK10.37816618
114PRKACG0.37612184
115BTK0.37009040
116SGK2230.36713016
117SGK4940.36713016
118CSNK1A10.36040617
119MKNK20.35782701
120RPS6KB10.35622221
121CDK30.33172039
122ZAK0.32412145
123PRKACB0.31773410
124CDK50.31271730
125CSNK1D0.30462502
126PRKD10.30300416
127RET0.30027722
128PRKCB0.29302562
129EPHA20.29204437
130MST1R0.28901925
131PRKACA0.28866684
132TRIB30.28444691
133MYLK0.26826392
134GSK3A0.26813362
135TNK20.26078630
136IGF1R0.25345188
137SGK30.25211163
138MAP2K40.24993448
139DYRK30.24417720
140DYRK1A0.24163094
141PRKDC0.23435490
142CSNK1E0.23017675
143MAP2K10.22652192
144ALK0.21818449
145ADRBK10.21287441
146ROCK10.21267095
147CAMK1G0.20223999
148ZAP700.20149562
149PRKCA0.19474545
150SYK0.19310493
151CAMK2B0.19081135
152EGFR0.18732091
153PRKG10.18333129
154PRKAA20.18055497
155MAPK130.17509905
156PDGFRB0.16995268
157AKT10.16974527

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.48346456
2Protein export_Homo sapiens_hsa030605.91596105
3Sulfur metabolism_Homo sapiens_hsa009203.47831790
4Insulin secretion_Homo sapiens_hsa049113.09780238
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.07090161
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58742996
7Vibrio cholerae infection_Homo sapiens_hsa051102.42003916
8Type II diabetes mellitus_Homo sapiens_hsa049302.13971731
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12507968
10Type I diabetes mellitus_Homo sapiens_hsa049402.07159737
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02873228
12N-Glycan biosynthesis_Homo sapiens_hsa005101.81049030
13Selenocompound metabolism_Homo sapiens_hsa004501.75680298
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64276345
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58324648
16Lysosome_Homo sapiens_hsa041421.58198073
17Other glycan degradation_Homo sapiens_hsa005111.56484506
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.50551805
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47564974
20Cocaine addiction_Homo sapiens_hsa050301.47206445
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46091843
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38067283
23Regulation of autophagy_Homo sapiens_hsa041401.36103515
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33527602
25Ether lipid metabolism_Homo sapiens_hsa005651.33251525
26Folate biosynthesis_Homo sapiens_hsa007901.31736291
27Arginine biosynthesis_Homo sapiens_hsa002201.29853689
28Peroxisome_Homo sapiens_hsa041461.28490882
29Vitamin digestion and absorption_Homo sapiens_hsa049771.27199137
30Taste transduction_Homo sapiens_hsa047421.26497219
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22732095
32Oxidative phosphorylation_Homo sapiens_hsa001901.21673102
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20357896
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18787791
35Fatty acid metabolism_Homo sapiens_hsa012121.18324225
36Caffeine metabolism_Homo sapiens_hsa002321.12575500
37Circadian rhythm_Homo sapiens_hsa047101.11551630
38Tryptophan metabolism_Homo sapiens_hsa003801.10497691
39Retinol metabolism_Homo sapiens_hsa008301.08156046
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05823069
41Pancreatic secretion_Homo sapiens_hsa049721.01092982
42Propanoate metabolism_Homo sapiens_hsa006401.00428601
43Vitamin B6 metabolism_Homo sapiens_hsa007500.99347279
44ABC transporters_Homo sapiens_hsa020100.98135236
45Amphetamine addiction_Homo sapiens_hsa050310.96859222
46Chemical carcinogenesis_Homo sapiens_hsa052040.96229048
47Collecting duct acid secretion_Homo sapiens_hsa049660.95556492
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92984754
49Insulin resistance_Homo sapiens_hsa049310.90252157
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88592332
51Glucagon signaling pathway_Homo sapiens_hsa049220.87556001
52Galactose metabolism_Homo sapiens_hsa000520.85896975
53Sphingolipid metabolism_Homo sapiens_hsa006000.84041711
54Prolactin signaling pathway_Homo sapiens_hsa049170.83514122
55Thyroid hormone synthesis_Homo sapiens_hsa049180.82553482
56Nitrogen metabolism_Homo sapiens_hsa009100.81721572
57beta-Alanine metabolism_Homo sapiens_hsa004100.80538297
58Glutathione metabolism_Homo sapiens_hsa004800.78626607
59Bile secretion_Homo sapiens_hsa049760.76701898
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.76138482
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.74730816
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74149766
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74120329
64Phototransduction_Homo sapiens_hsa047440.72807371
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69593035
66Histidine metabolism_Homo sapiens_hsa003400.67301740
67Serotonergic synapse_Homo sapiens_hsa047260.66807241
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65565960
69Butanoate metabolism_Homo sapiens_hsa006500.64730241
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62815826
71Starch and sucrose metabolism_Homo sapiens_hsa005000.62106661
72Dopaminergic synapse_Homo sapiens_hsa047280.61982831
73Phenylalanine metabolism_Homo sapiens_hsa003600.59578160
74Synaptic vesicle cycle_Homo sapiens_hsa047210.58939626
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58824879
76Prion diseases_Homo sapiens_hsa050200.57278418
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55042362
78Cholinergic synapse_Homo sapiens_hsa047250.55000645
79Circadian entrainment_Homo sapiens_hsa047130.54187802
80Long-term depression_Homo sapiens_hsa047300.53494506
81Metabolic pathways_Homo sapiens_hsa011000.52766002
82Linoleic acid metabolism_Homo sapiens_hsa005910.51559502
83Glycerolipid metabolism_Homo sapiens_hsa005610.51361211
84PPAR signaling pathway_Homo sapiens_hsa033200.50549045
85Arginine and proline metabolism_Homo sapiens_hsa003300.49662349
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49142471
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48648959
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.46830745
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46787575
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46550099
91Cardiac muscle contraction_Homo sapiens_hsa042600.43909239
92Long-term potentiation_Homo sapiens_hsa047200.43069740
93Alcoholism_Homo sapiens_hsa050340.42742332
94GABAergic synapse_Homo sapiens_hsa047270.41144552
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40874924
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39900190
97Parkinsons disease_Homo sapiens_hsa050120.38864632
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38504411
99Renin secretion_Homo sapiens_hsa049240.38349427
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.37882864
101Glutamatergic synapse_Homo sapiens_hsa047240.37415520
102Estrogen signaling pathway_Homo sapiens_hsa049150.37119531
103Antigen processing and presentation_Homo sapiens_hsa046120.36978203
104Phagosome_Homo sapiens_hsa041450.36766790
105Inositol phosphate metabolism_Homo sapiens_hsa005620.35831446
106Insulin signaling pathway_Homo sapiens_hsa049100.34276935
107Fat digestion and absorption_Homo sapiens_hsa049750.32947897
108Fatty acid elongation_Homo sapiens_hsa000620.29619589
109Mineral absorption_Homo sapiens_hsa049780.27755050
110Lysine degradation_Homo sapiens_hsa003100.27038860
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26876923
112Legionellosis_Homo sapiens_hsa051340.26143084
113Tyrosine metabolism_Homo sapiens_hsa003500.25584878
114Morphine addiction_Homo sapiens_hsa050320.25247655
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25131567
116Fructose and mannose metabolism_Homo sapiens_hsa000510.24988946
117AMPK signaling pathway_Homo sapiens_hsa041520.23325488
118Rheumatoid arthritis_Homo sapiens_hsa053230.23025956
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22561730
120Protein digestion and absorption_Homo sapiens_hsa049740.21594490
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21508735
122Prostate cancer_Homo sapiens_hsa052150.21260262
123cAMP signaling pathway_Homo sapiens_hsa040240.17091877
124mTOR signaling pathway_Homo sapiens_hsa041500.16501101
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.15243071
126Renin-angiotensin system_Homo sapiens_hsa046140.14808886
127FoxO signaling pathway_Homo sapiens_hsa040680.14226350
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12298072
129Ovarian steroidogenesis_Homo sapiens_hsa049130.11206241
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10649272
131Fatty acid degradation_Homo sapiens_hsa000710.10458653
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10363343
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10226046
134Alzheimers disease_Homo sapiens_hsa050100.08658142
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.08426876
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08208598
137Arachidonic acid metabolism_Homo sapiens_hsa005900.06606851
138Thyroid cancer_Homo sapiens_hsa052160.06471448
139Melanogenesis_Homo sapiens_hsa049160.06278503
140Endometrial cancer_Homo sapiens_hsa052130.05624793

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