HEPH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.25221753
2intestinal cholesterol absorption (GO:0030299)5.97895980
3regulation of guanylate cyclase activity (GO:0031282)5.81503581
4angiotensin maturation (GO:0002003)5.75338913
5NADH metabolic process (GO:0006734)4.85811745
6receptor guanylyl cyclase signaling pathway (GO:0007168)4.80422667
7midgut development (GO:0007494)4.76169181
8low-density lipoprotein particle clearance (GO:0034383)4.63248600
9vitamin A metabolic process (GO:0006776)4.59597103
10virion attachment to host cell (GO:0019062)4.44667131
11adhesion of symbiont to host cell (GO:0044650)4.44667131
12desmosome organization (GO:0002934)4.44344163
13positive regulation of guanylate cyclase activity (GO:0031284)4.29981258
14regulation of systemic arterial blood pressure by hormone (GO:0001990)4.29032990
15regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.29032990
16endocrine process (GO:0050886)4.29032990
17lateral sprouting from an epithelium (GO:0060601)4.15820606
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.14742955
19regulation of cardioblast differentiation (GO:0051890)4.08640909
20positive regulation of glomerulus development (GO:0090193)4.04939312
21renal system process involved in regulation of blood volume (GO:0001977)3.98532956
22adhesion of symbiont to host (GO:0044406)3.98001168
23homocysteine metabolic process (GO:0050667)3.96116056
24regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.94030104
25regulation of systemic arterial blood pressure (GO:0003073)3.87602559
26fat-soluble vitamin biosynthetic process (GO:0042362)3.82987318
27regulation of cGMP biosynthetic process (GO:0030826)3.73593522
28hemidesmosome assembly (GO:0031581)3.54204323
29cellular glucuronidation (GO:0052695)3.51484706
30epithelial cell-cell adhesion (GO:0090136)3.51435990
31uronic acid metabolic process (GO:0006063)3.49702517
32glucuronate metabolic process (GO:0019585)3.49702517
33sequestering of extracellular ligand from receptor (GO:0035581)3.47310471
34cGMP biosynthetic process (GO:0006182)3.45431138
35diacylglycerol metabolic process (GO:0046339)3.45399851
36regulation of glomerulus development (GO:0090192)3.44810951
37regulation of cGMP metabolic process (GO:0030823)3.42600893
38gap junction assembly (GO:0016264)3.42022652
39white fat cell differentiation (GO:0050872)3.40346188
40chondrocyte proliferation (GO:0035988)3.38557539
41hormone catabolic process (GO:0042447)3.36878439
42actin filament depolymerization (GO:0030042)3.34271744
43establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.32042320
44fructose metabolic process (GO:0006000)3.30426647
45regulation of triglyceride catabolic process (GO:0010896)3.28966514
46digestive system process (GO:0022600)3.28855813
47negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.26465850
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.22326438
49positive regulation of respiratory burst (GO:0060267)3.18907419
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15192461
51ventricular cardiac muscle cell action potential (GO:0086005)3.13863836
52positive regulation of pseudopodium assembly (GO:0031274)3.11411326
53glomerulus development (GO:0032835)3.11388721
54flavonoid metabolic process (GO:0009812)3.09286941
55lipoprotein metabolic process (GO:0042157)3.09112552
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.08806016
57antibacterial humoral response (GO:0019731)3.08205311
58positive regulation of fatty acid oxidation (GO:0046321)3.04422533
59renal filtration (GO:0097205)3.04371288
60sodium ion export (GO:0071436)3.03348387
61positive regulation of glycoprotein biosynthetic process (GO:0010560)3.03199772
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02561903
63cell communication by electrical coupling (GO:0010644)3.01503096
64cell proliferation involved in metanephros development (GO:0072203)2.99591549
65bile acid and bile salt transport (GO:0015721)2.99076317
66phospholipid efflux (GO:0033700)2.98305310
67multicellular organismal catabolic process (GO:0044243)2.97993036
68negative regulation of myotube differentiation (GO:0010832)2.97900431
69auditory receptor cell differentiation (GO:0042491)2.97446038
70glucocorticoid biosynthetic process (GO:0006704)2.97099455
71embryonic skeletal joint morphogenesis (GO:0060272)2.95758747
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.95267983
73positive regulation of lipid catabolic process (GO:0050996)2.92328232
74acylglycerol biosynthetic process (GO:0046463)2.92026817
75neutral lipid biosynthetic process (GO:0046460)2.92026817
76cell communication involved in cardiac conduction (GO:0086065)2.91759751
77lipoprotein transport (GO:0042953)2.91575161
78paraxial mesoderm development (GO:0048339)2.91214618
79transcytosis (GO:0045056)2.90394985
80triglyceride biosynthetic process (GO:0019432)2.89827870
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88603440
82antimicrobial humoral response (GO:0019730)2.84894059
83negative regulation of keratinocyte proliferation (GO:0010839)2.84489557
84calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84073506
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84061960
86drug metabolic process (GO:0017144)2.83559085
87glomerular filtration (GO:0003094)2.82341971
88renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.82296156
89triglyceride catabolic process (GO:0019433)2.81740397
90cell proliferation involved in kidney development (GO:0072111)2.81499860
91multicellular organismal macromolecule metabolic process (GO:0044259)2.81248222
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.81163938
93respiratory tube development (GO:0030323)2.80036417
94urea cycle (GO:0000050)2.79517974
95multicellular organismal metabolic process (GO:0044236)2.79226208
96maintenance of gastrointestinal epithelium (GO:0030277)2.79179548
97digestion (GO:0007586)2.78695228
98glutamine family amino acid biosynthetic process (GO:0009084)2.78231203
99notochord development (GO:0030903)2.77090122
100plasma lipoprotein particle assembly (GO:0034377)2.75585141
101regulation of cholesterol homeostasis (GO:2000188)2.75324457
102regulation of pseudopodium assembly (GO:0031272)2.73791699
103positive regulation of cGMP metabolic process (GO:0030825)2.72998465
104response to phenylpropanoid (GO:0080184)2.72939955
105retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71982205
106sulfate transport (GO:0008272)2.71522799
107O-glycan processing (GO:0016266)2.71022253
108cellular response to nitric oxide (GO:0071732)2.70821893
109brown fat cell differentiation (GO:0050873)2.70340211
110positive regulation of cGMP biosynthetic process (GO:0030828)2.69445989
111negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67864071
112negative regulation of cartilage development (GO:0061037)2.67443359
113regulation of cellular extravasation (GO:0002691)2.67120249
114nucleoside diphosphate biosynthetic process (GO:0009133)2.66347556
115positive regulation of glucose import (GO:0046326)2.65735519
116organ formation (GO:0048645)2.65640715
117convergent extension (GO:0060026)2.65069993
118anterior/posterior axis specification, embryo (GO:0008595)2.65055185
119sodium ion homeostasis (GO:0055078)2.64890361
120proline biosynthetic process (GO:0006561)2.64098578
121regulation of bile acid biosynthetic process (GO:0070857)2.62304090
122peptide catabolic process (GO:0043171)2.61788478
123urea metabolic process (GO:0019627)2.60172001
124cGMP-mediated signaling (GO:0019934)2.59598280
125epithelial structure maintenance (GO:0010669)2.59589341
126protein-lipid complex assembly (GO:0065005)2.59565323
127cellular response to vitamin (GO:0071295)2.59396084
128positive regulation of glycoprotein metabolic process (GO:1903020)2.59331591
129very-low-density lipoprotein particle assembly (GO:0034379)2.58986846
130polyol transport (GO:0015791)2.58665567
131kidney morphogenesis (GO:0060993)2.57572908
132regulation of digestive system process (GO:0044058)2.56996613
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56557769
134regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.56236755
135sulfate transmembrane transport (GO:1902358)2.56081393
136prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.56080462
137positive regulation of fatty acid metabolic process (GO:0045923)2.55497178
138regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54429386
139positive regulation of triglyceride metabolic process (GO:0090208)2.54402070
140mesenchymal-epithelial cell signaling (GO:0060638)2.54119126
141vitamin transmembrane transport (GO:0035461)2.54108581
142sterol transport (GO:0015918)2.53471415
143cholesterol transport (GO:0030301)2.53471415
144lymph vessel development (GO:0001945)2.53368794
145modified amino acid transport (GO:0072337)2.53279266
146phospholipid homeostasis (GO:0055091)2.53262310
147regulation of tight junction assembly (GO:2000810)2.52654115
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.52528642
149regulation of cholesterol transport (GO:0032374)2.52309100
150regulation of sterol transport (GO:0032371)2.52309100
151mesenchymal cell proliferation (GO:0010463)2.52256765
152mesodermal cell differentiation (GO:0048333)2.52122274
153labyrinthine layer development (GO:0060711)2.50702115
154cholesterol homeostasis (GO:0042632)2.50075298
155negative regulation of hormone metabolic process (GO:0032351)2.49847674
156fat-soluble vitamin metabolic process (GO:0006775)2.49554826
157mesonephros development (GO:0001823)2.49191083
158oligosaccharide biosynthetic process (GO:0009312)2.48925173
159cardiac myofibril assembly (GO:0055003)2.48493361
160regulation of cholesterol storage (GO:0010885)2.48156238
161sterol homeostasis (GO:0055092)2.46653303
162drug catabolic process (GO:0042737)2.46272226
163transepithelial transport (GO:0070633)2.45878050
164regulation of transforming growth factor beta2 production (GO:0032909)2.44287279
165glycerol metabolic process (GO:0006071)2.43577630
166response to hepatocyte growth factor (GO:0035728)2.42355281
167cellular response to hepatocyte growth factor stimulus (GO:0035729)2.42355281
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42257259
169positive regulation of lipoprotein lipase activity (GO:0051006)2.42056204
170positive regulation of triglyceride lipase activity (GO:0061365)2.42056204
171negative regulation of sodium ion transport (GO:0010766)2.40991893
172neutral lipid catabolic process (GO:0046461)2.40457532
173acylglycerol catabolic process (GO:0046464)2.40457532
174epoxygenase P450 pathway (GO:0019373)2.40428901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.03680758
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94186215
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.41521899
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.33297325
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.07455036
6CLOCK_20551151_ChIP-Seq_293T_Human2.84089476
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60366652
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.26385546
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.24223473
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18536788
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12847383
12PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12129609
13TCF4_18268006_ChIP-ChIP_LS174T_Human2.02926113
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00276170
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98848743
16* SOX2_20726797_ChIP-Seq_SW620_Human1.94388759
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88023625
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84773841
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81568863
20GATA4_25053715_ChIP-Seq_YYC3_Human1.78313093
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75894636
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72939177
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71253340
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71253340
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71253340
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.69502991
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65996455
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.65664147
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.65652400
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63459253
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62640203
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61909924
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.59672171
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55705097
35CJUN_26792858_Chip-Seq_BT549_Human1.53294972
36RXR_22108803_ChIP-Seq_LS180_Human1.49138354
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46016333
38GATA1_22025678_ChIP-Seq_K562_Human1.45770585
39GATA6_25053715_ChIP-Seq_YYC3_Human1.45315525
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.45034969
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44075564
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.42957796
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42577880
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42056364
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.41662463
46GATA1_19941826_ChIP-Seq_K562_Human1.40339077
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40267298
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39352310
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38309401
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35941007
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.35664629
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34056500
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33976893
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33976893
55BCAT_22108803_ChIP-Seq_LS180_Human1.33066763
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32592534
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31297633
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28576108
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27294795
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27195657
61KLF5_25053715_ChIP-Seq_YYC3_Human1.26654986
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26544645
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26045388
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.25970824
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24773489
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.24646700
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24359264
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23491364
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23491364
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22971642
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22904594
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.22613712
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22502965
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22485030
75* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22366057
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21350782
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20134309
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20056603
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.17676246
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16655475
81EZH2_22144423_ChIP-Seq_EOC_Human1.15378042
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14806967
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14792488
84* GATA2_19941826_ChIP-Seq_K562_Human1.14665026
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13411469
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11739791
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11302228
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.11101840
89EGR1_19032775_ChIP-ChIP_M12_Human1.10619717
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10406705
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10345599
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.09094907
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07398683
94AHR_22903824_ChIP-Seq_MCF-7_Human1.06852108
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.06679092
96CDX2_22108803_ChIP-Seq_LS180_Human1.05813389
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05287124
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05086765
99NANOG_16153702_ChIP-ChIP_HESCs_Human1.05060407
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04552154
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03487881
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03487881
103AR_21909140_ChIP-Seq_LNCAP_Human1.03238326
104TP53_18474530_ChIP-ChIP_U2OS_Human1.02334156
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01815902
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00916922
107TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00569358
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00535020
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00461895
110TP63_23658742_ChIP-Seq_EP156T_Human1.00455647
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00421100
112TP53_16413492_ChIP-PET_HCT116_Human1.00018586
113NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97913915
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97299427
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.97269364
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97148089
117JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96739924
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96006571
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95791700
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95280714
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94489753
122CTCF_27219007_Chip-Seq_Bcells_Human0.94268573
123DROSHA_22980978_ChIP-Seq_HELA_Human0.93870315
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93344405
125* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92907989
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92881037
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.91843624
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91591878
129TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90713967
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90630484
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90574872
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90204038
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89971880
134RACK7_27058665_Chip-Seq_MCF-7_Human0.89620658
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88522681
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.88385170
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88084154
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87988361
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87724165
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.87358103
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86970245
142VDR_22108803_ChIP-Seq_LS180_Human0.86960436
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86772303
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86305951
145* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86093003
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85181799
147FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83310631
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.82119696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.50146596
2MP0010234_abnormal_vibrissa_follicle4.23794347
3MP0000537_abnormal_urethra_morphology3.61936282
4MP0009379_abnormal_foot_pigmentation3.53572091
5MP0003705_abnormal_hypodermis_morpholog3.27962225
6MP0001666_abnormal_nutrient_absorption3.27575820
7MP0009053_abnormal_anal_canal2.65552391
8MP0009384_cardiac_valve_regurgitation2.58022968
9MP0005670_abnormal_white_adipose2.53167351
10MP0003941_abnormal_skin_development2.48728587
11MP0008438_abnormal_cutaneous_collagen2.48100212
12MP0005275_abnormal_skin_tensile2.44499935
13MP0002796_impaired_skin_barrier2.44009507
14MP0010329_abnormal_lipoprotein_level2.36152382
15MP0006054_spinal_hemorrhage2.31792959
16MP0005666_abnormal_adipose_tissue2.22362575
17MP0004272_abnormal_basement_membrane2.15492689
18MP0005503_abnormal_tendon_morphology2.11885207
19MP0004185_abnormal_adipocyte_glucose2.00301931
20MP0005409_darkened_coat_color1.98814152
21MP0000462_abnormal_digestive_system1.95534127
22MP0010678_abnormal_skin_adnexa1.94148523
23MP0004858_abnormal_nervous_system1.91505519
24MP0002254_reproductive_system_inflammat1.87339216
25MP0005375_adipose_tissue_phenotype1.71034043
26MP0003191_abnormal_cellular_cholesterol1.69281957
27MP0003252_abnormal_bile_duct1.66664092
28MP0003385_abnormal_body_wall1.66016143
29MP0000383_abnormal_hair_follicle1.61720682
30MP0000678_abnormal_parathyroid_gland1.61237946
31MP0008775_abnormal_heart_ventricle1.60331233
32MP0005377_hearing/vestibular/ear_phenot1.57560924
33MP0003878_abnormal_ear_physiology1.57560924
34MP0003567_abnormal_fetal_cardiomyocyte1.54153257
35MP0004215_abnormal_myocardial_fiber1.49925030
36MP0002060_abnormal_skin_morphology1.47223905
37MP0000516_abnormal_urinary_system1.43843610
38MP0005367_renal/urinary_system_phenotyp1.43843610
39MP0004084_abnormal_cardiac_muscle1.42512095
40MP0005257_abnormal_intraocular_pressure1.42199723
41MP0000467_abnormal_esophagus_morphology1.40840125
42MP0009780_abnormal_chondrocyte_physiolo1.40454752
43MP0002876_abnormal_thyroid_physiology1.39821686
44MP0000490_abnormal_crypts_of1.39346611
45MP0002098_abnormal_vibrissa_morphology1.38702500
46MP0000003_abnormal_adipose_tissue1.36717375
47MP0004130_abnormal_muscle_cell1.34824598
48MP0009115_abnormal_fat_cell1.34268825
49MP0005501_abnormal_skin_physiology1.31384899
50MP0010030_abnormal_orbit_morphology1.31252930
51MP0000538_abnormal_urinary_bladder1.28395401
52MP0005248_abnormal_Harderian_gland1.28165334
53MP0000013_abnormal_adipose_tissue1.26924763
54MP0003123_paternal_imprinting1.25553299
55MP0000566_synostosis1.25054272
56MP0004270_analgesia1.23067690
57MP0006138_congestive_heart_failure1.22742385
58MP0001879_abnormal_lymphatic_vessel1.22133866
59MP0010368_abnormal_lymphatic_system1.20452204
60MP0001299_abnormal_eye_distance/1.19894343
61MP0010352_gastrointestinal_tract_polyps1.18453844
62MP0000427_abnormal_hair_cycle1.15369932
63MP0009250_abnormal_appendicular_skeleto1.13987860
64MP0010155_abnormal_intestine_physiology1.13886514
65MP0001293_anophthalmia1.12632435
66MP0005167_abnormal_blood-brain_barrier1.12269809
67* MP0004264_abnormal_extraembryonic_tissu1.11051235
68MP0002139_abnormal_hepatobiliary_system1.10705944
69MP0002938_white_spotting1.10326108
70MP0003942_abnormal_urinary_system1.09521748
71MP0003315_abnormal_perineum_morphology1.09501246
72MP0003868_abnormal_feces_composition1.08871457
73MP0003119_abnormal_digestive_system1.08399054
74MP0008875_abnormal_xenobiotic_pharmacok1.07501003
75MP0000534_abnormal_ureter_morphology1.07374024
76MP0009840_abnormal_foam_cell1.07255270
77MP0003183_abnormal_peptide_metabolism1.06981603
78MP0004043_abnormal_pH_regulation1.06291149
79MP0002089_abnormal_postnatal_growth/wei1.05682507
80MP0002971_abnormal_brown_adipose1.04319817
81MP0009697_abnormal_copulation1.04254141
82MP0002697_abnormal_eye_size1.03519842
83MP0003828_pulmonary_edema1.00979246
84MP0005332_abnormal_amino_acid1.00839748
85MP0002896_abnormal_bone_mineralization1.00367194
86MP0005448_abnormal_energy_balance0.99406779
87MP0005085_abnormal_gallbladder_physiolo0.98136554
88MP0004957_abnormal_blastocyst_morpholog0.96820692
89MP0002249_abnormal_larynx_morphology0.95778623
90* MP0000477_abnormal_intestine_morphology0.95401074
91MP0001958_emphysema0.95326533
92MP0001485_abnormal_pinna_reflex0.94830539
93MP0001188_hyperpigmentation0.94661949
94MP0002009_preneoplasia0.92444416
95MP0005381_digestive/alimentary_phenotyp0.92398498
96MP0005365_abnormal_bile_salt0.92147430
97MP0001216_abnormal_epidermal_layer0.91688740
98MP0000432_abnormal_head_morphology0.91602951
99MP0003866_abnormal_defecation0.90591655
100MP0003115_abnormal_respiratory_system0.89814941
101MP0009643_abnormal_urine_homeostasis0.89637535
102MP0004019_abnormal_vitamin_homeostasis0.89529187
103MP0003950_abnormal_plasma_membrane0.88772719
104MP0002118_abnormal_lipid_homeostasis0.88759453
105MP0002233_abnormal_nose_morphology0.88247068
106MP0003938_abnormal_ear_development0.88095845
107MP0003453_abnormal_keratinocyte_physiol0.87710409
108MP0000762_abnormal_tongue_morphology0.85946170
109MP0001663_abnormal_digestive_system0.85662994
110MP0003279_aneurysm0.85334644
111MP0004782_abnormal_surfactant_physiolog0.84847869
112MP0000377_abnormal_hair_follicle0.84243612
113MP0010771_integument_phenotype0.84231622
114MP0001664_abnormal_digestion0.83982234
115MP0010630_abnormal_cardiac_muscle0.83385063
116MP0000230_abnormal_systemic_arterial0.83377273
117MP0003137_abnormal_impulse_conducting0.82373198
118MP0003300_gastrointestinal_ulcer0.82234013
119MP0002282_abnormal_trachea_morphology0.82122405
120MP0004085_abnormal_heartbeat0.81822685
121MP0005508_abnormal_skeleton_morphology0.80074787
122MP0001765_abnormal_ion_homeostasis0.80025253
123MP0001849_ear_inflammation0.79288305
124MP0003937_abnormal_limbs/digits/tail_de0.79119741
125MP0001544_abnormal_cardiovascular_syste0.78949481
126MP0005385_cardiovascular_system_phenoty0.78949481
127MP0005334_abnormal_fat_pad0.78543145
128MP0000579_abnormal_nail_morphology0.78477032
129MP0005330_cardiomyopathy0.78307666
130MP0002084_abnormal_developmental_patter0.78200782
131MP0002972_abnormal_cardiac_muscle0.78008775
132MP0001177_atelectasis0.77682406
133MP0000049_abnormal_middle_ear0.76574175
134MP0003283_abnormal_digestive_organ0.75941314
135MP0002085_abnormal_embryonic_tissue0.75645944
136MP0005187_abnormal_penis_morphology0.75437958
137MP0003935_abnormal_craniofacial_develop0.74941045
138MP0000751_myopathy0.73869458
139MP0002111_abnormal_tail_morphology0.72862273
140MP0005023_abnormal_wound_healing0.72077407
141MP0003755_abnormal_palate_morphology0.70797666
142MP0003718_maternal_effect0.70677856
143MP0000428_abnormal_craniofacial_morphol0.70624153
144MP0002127_abnormal_cardiovascular_syste0.69798618
145MP0003122_maternal_imprinting0.69539733
146MP0003566_abnormal_cell_adhesion0.69407382
147* MP0005636_abnormal_mineral_homeostasis0.69124531
148MP0001881_abnormal_mammary_gland0.67902100
149MP0001286_abnormal_eye_development0.67636385
150MP0005620_abnormal_muscle_contractility0.67175221

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)5.11781554
2Right ventricular cardiomyopathy (HP:0011663)4.76015694
3Hyperactive renin-angiotensin system (HP:0000841)4.40181674
4Abnormality of proline metabolism (HP:0010907)3.72108756
5Hydroxyprolinuria (HP:0003080)3.72108756
6Rectal prolapse (HP:0002035)3.64663365
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60647217
8Metabolic alkalosis (HP:0200114)3.56139039
9Abnormality of the vitamin B12 metabolism (HP:0004341)3.49698543
10Mesangial abnormality (HP:0001966)3.37330772
11Pigmentary retinal degeneration (HP:0001146)3.31055411
12Autoimmune thrombocytopenia (HP:0001973)3.29835220
13Short hallux (HP:0010109)3.19194747
14Premature rupture of membranes (HP:0001788)3.16141247
15Acanthosis nigricans (HP:0000956)3.16104777
16Decreased circulating renin level (HP:0003351)3.15053630
17Abnormality of the middle phalanges of the toes (HP:0010183)3.14284892
18Abnormality of vitamin B metabolism (HP:0004340)3.11530603
19Hepatoblastoma (HP:0002884)3.06643053
20Aplasia involving bones of the extremities (HP:0009825)2.99831201
21Aplasia involving bones of the upper limbs (HP:0009823)2.99831201
22Aplasia of the phalanges of the hand (HP:0009802)2.99831201
23Abnormality of renin-angiotensin system (HP:0000847)2.97127989
24Confusion (HP:0001289)2.91389091
25Flat acetabular roof (HP:0003180)2.89652249
26Abnormality of the 1st metacarpal (HP:0010009)2.89149925
27Ventricular tachycardia (HP:0004756)2.87170603
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.87120670
29Partial duplication of thumb phalanx (HP:0009944)2.85203974
30Aplasia/Hypoplasia of the hallux (HP:0008362)2.83398400
31Broad metatarsal (HP:0001783)2.77898145
32Delayed epiphyseal ossification (HP:0002663)2.77384788
33Atrophic scars (HP:0001075)2.75923604
34Hyperglycinuria (HP:0003108)2.75614069
35Syncope (HP:0001279)2.74588703
36Abnormality of the nasal septum (HP:0000419)2.73794212
37Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.73322120
38Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.68878859
39Short 1st metacarpal (HP:0010034)2.68878859
40Short phalanx of the thumb (HP:0009660)2.64540544
41Humeroradial synostosis (HP:0003041)2.63201334
42Synostosis involving the elbow (HP:0003938)2.63201334
43Fragile skin (HP:0001030)2.61811281
44Broad toe (HP:0001837)2.60241021
45Wide cranial sutures (HP:0010537)2.59990353
46Milia (HP:0001056)2.59288217
47Malnutrition (HP:0004395)2.57318909
48Partial duplication of the phalanx of hand (HP:0009999)2.56691935
49Proximal tubulopathy (HP:0000114)2.56550130
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.54487616
51Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47955116
52Short 4th metacarpal (HP:0010044)2.47955116
53Abnormality of vitamin metabolism (HP:0100508)2.45506714
54Fat malabsorption (HP:0002630)2.39691746
55Abnormality of the 4th metacarpal (HP:0010012)2.38415428
56Woolly hair (HP:0002224)2.37765185
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.35528232
58Cupped ribs (HP:0000887)2.34849919
59Aortic aneurysm (HP:0004942)2.34559673
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.33462302
61Broad hallux (HP:0010055)2.32195676
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.32189301
63Abnormal tarsal ossification (HP:0008369)2.29212986
64Alkalosis (HP:0001948)2.26798075
65Abnormal biliary tract morphology (HP:0012440)2.26593952
66Acanthocytosis (HP:0001927)2.23180514
67Hyperaldosteronism (HP:0000859)2.21772332
68Oligomenorrhea (HP:0000876)2.21139035
69Abnormality of chloride homeostasis (HP:0011422)2.19795815
70Abnormality of the distal phalanges of the toes (HP:0010182)2.19361441
71Nausea (HP:0002018)2.18915981
72Biliary tract neoplasm (HP:0100574)2.18184543
73Vitreoretinal degeneration (HP:0000655)2.17622013
74Epidermoid cyst (HP:0200040)2.15884231
75Nephrolithiasis (HP:0000787)2.14882731
76Morphological abnormality of the middle ear (HP:0008609)2.13597915
77Bladder diverticulum (HP:0000015)2.12931870
78Palpitations (HP:0001962)2.12664804
79Cervical subluxation (HP:0003308)2.11972248
80Abnormality of the 2nd finger (HP:0004100)2.10431635
81Vertebral clefting (HP:0008428)2.10040476
82Abnormality of the phalanges of the 5th finger (HP:0004213)2.09661813
83Disproportionate tall stature (HP:0001519)2.09223704
84Shallow orbits (HP:0000586)2.07504701
85Hypobetalipoproteinemia (HP:0003563)2.07208166
86Mildly elevated creatine phosphokinase (HP:0008180)2.05078230
87Visceral angiomatosis (HP:0100761)2.04983187
88Breech presentation (HP:0001623)2.04039098
89Gastrointestinal dysmotility (HP:0002579)2.02031335
90Vascular tortuosity (HP:0004948)2.01094710
91Hypolipoproteinemia (HP:0010981)2.01064927
92Hemangiomatosis (HP:0007461)2.01006150
93Neonatal hypoglycemia (HP:0001998)1.99479953
94Short middle phalanx of finger (HP:0005819)1.99244368
95Neoplasm of the rectum (HP:0100743)1.98372591
96Arterial tortuosity (HP:0005116)1.98331551
97Short humerus (HP:0005792)1.98126722
98Potter facies (HP:0002009)1.97976289
99Facial shape deformation (HP:0011334)1.97976289
100Abnormality of the middle phalanges of the hand (HP:0009833)1.97141399
101Abnormal pancreas size (HP:0012094)1.96737981
102Aortic dissection (HP:0002647)1.96447498
103Abnormality of the lacrimal duct (HP:0011481)1.95985949
104Protrusio acetabuli (HP:0003179)1.95858726
105Abnormality of the aortic arch (HP:0012303)1.95389984
106Preaxial foot polydactyly (HP:0001841)1.94916966
107Cutaneous finger syndactyly (HP:0010554)1.94550163
108Abnormality of the nasolacrimal system (HP:0000614)1.93698064
109Nasolacrimal duct obstruction (HP:0000579)1.90344447
110Abnormality of urine glucose concentration (HP:0011016)1.90183271
111Glycosuria (HP:0003076)1.90183271
112Neoplasm of the small intestine (HP:0100833)1.90124689
113Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.89579035
114Hypokalemia (HP:0002900)1.89225652
115Turricephaly (HP:0000262)1.89098276
116Pili torti (HP:0003777)1.88851553
117Abnormality of glycine metabolism (HP:0010895)1.88823571
118Abnormality of serine family amino acid metabolism (HP:0010894)1.88823571
119Cutaneous syndactyly (HP:0012725)1.88669897
120Ankyloglossia (HP:0010296)1.88386144
121Sudden death (HP:0001699)1.87796245
122Bronchomalacia (HP:0002780)1.87321010
123Abnormal glucose tolerance (HP:0001952)1.86751821
124Tarsal synostosis (HP:0008368)1.86580719
125Neonatal short-limb short stature (HP:0008921)1.86500014
126Lymphangioma (HP:0100764)1.85636133
127Bone cyst (HP:0012062)1.84574549
128Congenital sensorineural hearing impairment (HP:0008527)1.83019487
129Abnormality of the phalanges of the hallux (HP:0010057)1.83009745
130Fragile nails (HP:0001808)1.81966152
131Broad palm (HP:0001169)1.81786433
132Hypertriglyceridemia (HP:0002155)1.80981302
133Thin ribs (HP:0000883)1.80628488
134Vertebral hypoplasia (HP:0008417)1.80041676
135Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80041676
136Abdominal distention (HP:0003270)1.78470154
137Hematochezia (HP:0002573)1.78304743
138Flattened epiphyses (HP:0003071)1.77095502
139Duplication of thumb phalanx (HP:0009942)1.76948859
140Intrahepatic cholestasis (HP:0001406)1.76823809
141Coronal craniosynostosis (HP:0004440)1.76193768
142Midline defect of the nose (HP:0004122)1.75121402
143Hypoplastic labia majora (HP:0000059)1.75057500
144Advanced eruption of teeth (HP:0006288)1.74900529
145Patent foramen ovale (HP:0001655)1.74762168
146Widely patent fontanelles and sutures (HP:0004492)1.73907735
147Long nose (HP:0003189)1.73514411
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73185495
149Enlarged epiphyses (HP:0010580)1.71774111
150Short middle phalanx of the 5th finger (HP:0004220)1.71435634
151Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71191978
152Germ cell neoplasia (HP:0100728)1.70482423
153Focal segmental glomerulosclerosis (HP:0000097)1.69927848
154Thin bony cortex (HP:0002753)1.69825880
155Abnormality of potassium homeostasis (HP:0011042)1.69482232
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69307173
157Soft skin (HP:0000977)1.69054064
158Autoimmune hemolytic anemia (HP:0001890)1.68981667
159Increased connective tissue (HP:0009025)1.68031144
160Pterygium (HP:0001059)1.67894620
161Accelerated skeletal maturation (HP:0005616)1.67583735
162Onycholysis (HP:0001806)1.67474304
163Chronic diarrhea (HP:0002028)1.67218942
164Flat capital femoral epiphysis (HP:0003370)1.67154900
165Increased purine levels (HP:0004368)1.66566041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.17072525
2ACVR1B4.91691919
3LMTK24.87144349
4LATS14.11865229
5MST1R3.62965520
6TNIK3.10618046
7MST43.09743879
8EPHB22.96199444
9RIPK12.69564152
10CAMK1D2.59777506
11NUAK12.28293793
12TRIB32.21516095
13STK392.06023701
14PRKG22.01696455
15NTRK11.97190155
16PTK61.93477603
17FER1.88853450
18PIK3CA1.80796917
19DDR21.79097414
20STK241.77251031
21MAP2K21.75647488
22FGFR41.74715671
23CASK1.73305984
24AKT31.73252217
25SIK11.63115278
26MAP3K101.61513396
27CAMK1G1.59653225
28MET1.57190446
29EPHA31.56223626
30PDGFRA1.56093845
31KSR21.54080510
32MYLK1.51216178
33INSRR1.49602157
34FGFR21.43537384
35EPHA21.36070355
36OXSR11.31002712
37PRKAA21.30269530
38MAP3K21.25150418
39TIE11.23585273
40MKNK11.18696517
41MAP2K11.12853944
42LATS21.11687528
43EEF2K1.08314104
44STK31.05445823
45PDK21.05445377
46FGFR11.05106020
47PRKD31.04994604
48CDK61.04643800
49ERBB21.03746062
50ERN11.03136399
51CDK191.02893483
52TGFBR10.99411800
53TYRO30.98523276
54KDR0.95217219
55DMPK0.93566761
56TESK10.91899367
57EPHA40.90098820
58CDC42BPA0.89858517
59RET0.86465160
60CDK90.85960207
61FGFR30.84176601
62NEK90.83619102
63NTRK30.82937420
64CLK10.81709591
65PTK20.77448583
66BCR0.76564459
67PAK20.75308506
68TAOK20.74678144
69BMX0.74636683
70PAK30.73317306
71WNK40.71585383
72KSR10.71388732
73STK100.71254047
74OBSCN0.71078949
75LRRK20.71032140
76MKNK20.68918359
77TTN0.65906278
78MAP3K30.62208922
79ROCK10.61152097
80TGFBR20.58828702
81MAPK150.58707319
82PDK30.57874590
83PDK40.57874590
84PLK40.57266344
85STK38L0.56487458
86WNK10.55504716
87PDGFRB0.53863842
88EPHB10.53373462
89PRKAA10.52204512
90MATK0.50717342
91TSSK60.49884019
92GRK10.49721733
93DYRK1B0.48406196
94DYRK30.47411014
95GRK60.46545507
96MAP3K80.46149050
97MAP3K10.45718641
98ERBB30.45655659
99MAP3K120.45481984
100SGK30.45281470
101SRC0.44326534
102PAK40.44026794
103GSK3A0.43746280
104RPS6KA40.43009778
105IGF1R0.42265196
106CAMK2D0.40603286
107ROCK20.39846559
108MTOR0.39831157
109PKN20.39102452
110NEK20.38646876
111MAPK110.37561754
112PNCK0.37041426
113MAP3K70.36780221
114PRKD10.36350542
115BMPR1B0.34361755
116TTK0.34069100
117BRSK20.33933881
118PTK2B0.33356562
119PRKCA0.32461611
120MAP3K40.32234777
121INSR0.31818359
122TAOK10.31192827
123DAPK30.30970641
124NME10.30908324
125PHKG10.30492508
126PHKG20.30492508
127PRKCE0.29026308
128MELK0.28500532
129YES10.28283295
130PDPK10.27069390
131DYRK20.25943921
132NLK0.25657835
133RPS6KA20.25273656
134CDK11A0.24391756
135CDK120.24365559
136PRKACG0.23522047
137TRPM70.23386394
138FLT30.23056940
139PRKCZ0.22714970
140ICK0.22470186
141NEK10.22428095
142PASK0.22212492
143MAPKAPK30.21319889
144CDK150.21217508
145MAPK70.21087393
146BCKDK0.20662673
147CAMK40.20108544

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.83319296
2Renin-angiotensin system_Homo sapiens_hsa046143.20660481
3* Mineral absorption_Homo sapiens_hsa049782.92244619
4Vitamin digestion and absorption_Homo sapiens_hsa049772.84748738
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.75503239
6PPAR signaling pathway_Homo sapiens_hsa033202.71044505
7Caffeine metabolism_Homo sapiens_hsa002322.59836845
8Protein digestion and absorption_Homo sapiens_hsa049742.55257916
9Fatty acid biosynthesis_Homo sapiens_hsa000612.42271429
10Sulfur metabolism_Homo sapiens_hsa009202.27735018
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06757836
12Glycerolipid metabolism_Homo sapiens_hsa005611.97324114
13Starch and sucrose metabolism_Homo sapiens_hsa005001.91528650
14Galactose metabolism_Homo sapiens_hsa000521.78814770
15Bile secretion_Homo sapiens_hsa049761.78379361
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.77289578
17Fatty acid degradation_Homo sapiens_hsa000711.65654926
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62503935
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60190988
20Propanoate metabolism_Homo sapiens_hsa006401.59449097
21Arginine and proline metabolism_Homo sapiens_hsa003301.49955670
22Fatty acid metabolism_Homo sapiens_hsa012121.49408070
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42694685
24Basal cell carcinoma_Homo sapiens_hsa052171.35385309
25Adherens junction_Homo sapiens_hsa045201.33405758
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28830438
27Nitrogen metabolism_Homo sapiens_hsa009101.21137633
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21059509
29ECM-receptor interaction_Homo sapiens_hsa045121.19918249
30Tight junction_Homo sapiens_hsa045301.18606671
31Glutathione metabolism_Homo sapiens_hsa004801.17896548
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14014700
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12734492
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09759741
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08421226
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.06499292
37Sphingolipid metabolism_Homo sapiens_hsa006001.05057713
38TGF-beta signaling pathway_Homo sapiens_hsa043501.03161176
39Hippo signaling pathway_Homo sapiens_hsa043901.03152133
40Fructose and mannose metabolism_Homo sapiens_hsa000511.00747677
41ABC transporters_Homo sapiens_hsa020100.95690173
42Histidine metabolism_Homo sapiens_hsa003400.93643841
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88267462
44beta-Alanine metabolism_Homo sapiens_hsa004100.86115834
45Thyroid hormone synthesis_Homo sapiens_hsa049180.86011045
46AMPK signaling pathway_Homo sapiens_hsa041520.84546816
47Biosynthesis of amino acids_Homo sapiens_hsa012300.81443580
48Focal adhesion_Homo sapiens_hsa045100.80097190
49Ether lipid metabolism_Homo sapiens_hsa005650.79883061
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.79278895
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78744091
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.78632110
53Tryptophan metabolism_Homo sapiens_hsa003800.78580815
54Pyruvate metabolism_Homo sapiens_hsa006200.78030441
55Proteoglycans in cancer_Homo sapiens_hsa052050.77689046
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77445095
57Folate biosynthesis_Homo sapiens_hsa007900.77114820
58Insulin resistance_Homo sapiens_hsa049310.76611480
59Hedgehog signaling pathway_Homo sapiens_hsa043400.75748463
60Retinol metabolism_Homo sapiens_hsa008300.70318298
61Small cell lung cancer_Homo sapiens_hsa052220.68951259
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67937808
63* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67848652
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67291195
65Renin secretion_Homo sapiens_hsa049240.66708728
66Carbon metabolism_Homo sapiens_hsa012000.66296853
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66231609
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65971886
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.65404568
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.63095585
71Lysine degradation_Homo sapiens_hsa003100.62627167
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.61514697
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.60529296
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60470059
75Chemical carcinogenesis_Homo sapiens_hsa052040.60178319
76Ovarian steroidogenesis_Homo sapiens_hsa049130.59793815
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59613289
78Melanogenesis_Homo sapiens_hsa049160.59247293
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56822440
80Cardiac muscle contraction_Homo sapiens_hsa042600.55163720
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54514746
82Dilated cardiomyopathy_Homo sapiens_hsa054140.53269950
83Butanoate metabolism_Homo sapiens_hsa006500.53172443
84Arginine biosynthesis_Homo sapiens_hsa002200.53015357
85Arachidonic acid metabolism_Homo sapiens_hsa005900.50725472
86Peroxisome_Homo sapiens_hsa041460.49567303
87Phenylalanine metabolism_Homo sapiens_hsa003600.47335506
88Thyroid cancer_Homo sapiens_hsa052160.47138234
89Gap junction_Homo sapiens_hsa045400.46875167
90Pentose phosphate pathway_Homo sapiens_hsa000300.44598441
91Amoebiasis_Homo sapiens_hsa051460.43923913
92Wnt signaling pathway_Homo sapiens_hsa043100.43390511
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41424971
94Linoleic acid metabolism_Homo sapiens_hsa005910.40996016
95Gastric acid secretion_Homo sapiens_hsa049710.40940705
96Pancreatic secretion_Homo sapiens_hsa049720.40467523
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.39947256
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38918931
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38661682
100Axon guidance_Homo sapiens_hsa043600.37065277
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36160538
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.35097332
103Bladder cancer_Homo sapiens_hsa052190.34834222
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34746332
105Insulin secretion_Homo sapiens_hsa049110.34592801
106MicroRNAs in cancer_Homo sapiens_hsa052060.34270339
107Pathways in cancer_Homo sapiens_hsa052000.34088483
108Type II diabetes mellitus_Homo sapiens_hsa049300.33857662
109Rap1 signaling pathway_Homo sapiens_hsa040150.32989436
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32958210
111Prostate cancer_Homo sapiens_hsa052150.32494920
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32400338
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31919305
114Sulfur relay system_Homo sapiens_hsa041220.31917248
115Insulin signaling pathway_Homo sapiens_hsa049100.30928182
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29112337
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28716864
118Cocaine addiction_Homo sapiens_hsa050300.27989299
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26477522
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25084912
121Metabolic pathways_Homo sapiens_hsa011000.22530968
122Other glycan degradation_Homo sapiens_hsa005110.19351565
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15665344
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14112686
125Tyrosine metabolism_Homo sapiens_hsa003500.12895724

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