HEPHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.94350728
2regulation of water loss via skin (GO:0033561)8.72443667
3long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)8.29237904
4fatty acid elongation (GO:0030497)8.27768696
5fatty-acyl-CoA biosynthetic process (GO:0046949)8.04073697
6long-chain fatty-acyl-CoA metabolic process (GO:0035336)7.30738191
7intermediate filament organization (GO:0045109)7.13680212
8acyl-CoA biosynthetic process (GO:0071616)7.09884546
9thioester biosynthetic process (GO:0035384)7.09884546
10cell-substrate junction assembly (GO:0007044)7.08213989
11fatty-acyl-CoA metabolic process (GO:0035337)6.56476314
12peptide cross-linking (GO:0018149)6.40392573
13keratinocyte differentiation (GO:0030216)6.35216460
14cell adhesion mediated by integrin (GO:0033627)6.12203392
15long-chain fatty acid biosynthetic process (GO:0042759)6.09481423
16linoleic acid metabolic process (GO:0043651)6.00303672
17ectoderm development (GO:0007398)5.88553448
18multicellular organismal water homeostasis (GO:0050891)5.82157232
19hemidesmosome assembly (GO:0031581)5.50348845
20adhesion of symbiont to host cell (GO:0044650)5.43112202
21virion attachment to host cell (GO:0019062)5.43112202
22keratinocyte proliferation (GO:0043616)5.41050216
23bundle of His cell to Purkinje myocyte communication (GO:0086069)5.23018730
24epidermis development (GO:0008544)5.11990278
25regulation of sequestering of triglyceride (GO:0010889)5.04682330
26hypotonic response (GO:0006971)4.98876680
27epidermal cell differentiation (GO:0009913)4.95736914
28adhesion of symbiont to host (GO:0044406)4.94111036
29mesodermal cell differentiation (GO:0048333)4.88987304
30water homeostasis (GO:0030104)4.83103029
31regulation of keratinocyte proliferation (GO:0010837)4.66774327
32triglyceride biosynthetic process (GO:0019432)4.66764626
33oligosaccharide biosynthetic process (GO:0009312)4.50927487
34acylglycerol biosynthetic process (GO:0046463)4.47887541
35neutral lipid biosynthetic process (GO:0046460)4.47887541
36keratinocyte development (GO:0003334)4.47028069
37tooth mineralization (GO:0034505)4.40050239
38intermediate filament cytoskeleton organization (GO:0045104)4.20459300
39gap junction assembly (GO:0016264)4.19220845
40dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.19108740
41citrulline biosynthetic process (GO:0019240)4.16902696
42endodermal cell differentiation (GO:0035987)4.11758962
43intermediate filament-based process (GO:0045103)4.09672035
44pattern specification involved in kidney development (GO:0061004)4.09127258
45skin morphogenesis (GO:0043589)4.07566061
46hair follicle morphogenesis (GO:0031069)4.02683448
47lipoxygenase pathway (GO:0019372)4.02395852
48negative regulation of keratinocyte proliferation (GO:0010839)3.93460257
49carnitine shuttle (GO:0006853)3.91000789
50diterpenoid biosynthetic process (GO:0016102)3.89714133
51establishment of planar polarity (GO:0001736)3.83030382
52establishment of tissue polarity (GO:0007164)3.83030382
53fatty acid transmembrane transport (GO:1902001)3.74761851
54gland morphogenesis (GO:0022612)3.73271734
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.71382644
56positive regulation of actin cytoskeleton reorganization (GO:2000251)3.69668281
57regulation of hair follicle development (GO:0051797)3.69269929
58positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.68076855
59regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.68076855
60negative regulation of interferon-gamma production (GO:0032689)3.67827297
61alpha-linolenic acid metabolic process (GO:0036109)3.65356798
62thioester metabolic process (GO:0035383)3.63487725
63acyl-CoA metabolic process (GO:0006637)3.63487725
64pyrimidine-containing compound transmembrane transport (GO:0072531)3.63109832
65phosphatidylinositol acyl-chain remodeling (GO:0036149)3.62832398
66positive regulation of hair cycle (GO:0042635)3.62108255
67positive regulation of hair follicle development (GO:0051798)3.62108255
68negative regulation of interleukin-17 production (GO:0032700)3.61925882
69cell wall macromolecule catabolic process (GO:0016998)3.61629720
70cell wall macromolecule metabolic process (GO:0044036)3.61629720
71response to phenylpropanoid (GO:0080184)3.61055636
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.57025889
73biotin metabolic process (GO:0006768)3.56912176
74detection of bacterium (GO:0016045)3.48287710
75very long-chain fatty acid metabolic process (GO:0000038)3.46868807
76epithelium development (GO:0060429)3.43627313
77long-chain fatty acid transport (GO:0015909)3.43361945
78mammary gland epithelial cell differentiation (GO:0060644)3.39663389
79sphingoid metabolic process (GO:0046519)3.38361601
80sphingosine metabolic process (GO:0006670)3.37071720
81regulation of transforming growth factor beta2 production (GO:0032909)3.30250220
82sequestering of metal ion (GO:0051238)3.27595029
83negative regulation of chondrocyte differentiation (GO:0032331)3.25873624
84polarized epithelial cell differentiation (GO:0030859)3.21450453
85positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.20833241
86substrate-dependent cell migration (GO:0006929)3.20615400
87positive regulation of monocyte chemotaxis (GO:0090026)3.20302379
88acetyl-CoA metabolic process (GO:0006084)3.19015063
89detection of other organism (GO:0098543)3.18653509
90molting cycle process (GO:0022404)3.18598360
91hair cycle process (GO:0022405)3.18598360
92establishment of epithelial cell polarity (GO:0090162)3.17983573
93regulation of hair cycle (GO:0042634)3.17211092
94mammary gland epithelial cell proliferation (GO:0033598)3.14666402
95regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.13564188
96regulation of transforming growth factor beta1 production (GO:0032908)3.08884178
97positive regulation of glomerulus development (GO:0090193)3.08712372
98wound healing (GO:0042060)3.04701335
99regulation of epidermis development (GO:0045682)3.03529851
100fatty acid transport (GO:0015908)3.03398250
101diol metabolic process (GO:0034311)3.03069573
102positive regulation of keratinocyte differentiation (GO:0045618)3.00218793
103carnitine transmembrane transport (GO:1902603)3.00039765
104protein localization to endosome (GO:0036010)2.99779907
105coenzyme A biosynthetic process (GO:0015937)2.99399240
106low-density lipoprotein particle clearance (GO:0034383)2.99036050
107regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.97643608
108cell junction assembly (GO:0034329)2.93121819
109renal filtration (GO:0097205)2.92434392
110epithelial cell proliferation (GO:0050673)2.91211552
111lipid storage (GO:0019915)2.89274343
112phosphatidylserine acyl-chain remodeling (GO:0036150)2.89128920
113morphogenesis of embryonic epithelium (GO:0016331)2.88944126
114lung lobe morphogenesis (GO:0060463)2.88197435
115extracellular matrix disassembly (GO:0022617)2.87603356
116chemical homeostasis within a tissue (GO:0048875)2.87411576
117regulation of natural killer cell differentiation (GO:0032823)2.83884369
118regulation of transforming growth factor beta production (GO:0071634)2.82399857
119surfactant homeostasis (GO:0043129)2.81086705
120ethanol metabolic process (GO:0006067)2.81025560
121cell junction organization (GO:0034330)2.80560601
122phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.79421191
123positive regulation of p38MAPK cascade (GO:1900745)2.77348657
124white fat cell differentiation (GO:0050872)2.77226229
125atrioventricular valve morphogenesis (GO:0003181)2.77124658
126positive regulation of epidermal cell differentiation (GO:0045606)2.76936863
127triglyceride metabolic process (GO:0006641)2.76457174
128terpenoid biosynthetic process (GO:0016114)2.75866607
129fatty acid biosynthetic process (GO:0006633)2.73692898
130cellular copper ion homeostasis (GO:0006878)2.72824563
131amino-acid betaine transport (GO:0015838)2.72376162
132carnitine transport (GO:0015879)2.72376162
133phosphatidylcholine acyl-chain remodeling (GO:0036151)2.69617107
134phosphatidylserine metabolic process (GO:0006658)2.69563969
135lateral sprouting from an epithelium (GO:0060601)2.69061266
136epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67479961
137positive regulation of T cell chemotaxis (GO:0010820)2.66436611
138regulation of T cell chemotaxis (GO:0010819)2.66436611
139regulation of keratinocyte differentiation (GO:0045616)2.63528960
140lactation (GO:0007595)2.63158988
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62209251
142phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.61366404
143cytoskeletal anchoring at plasma membrane (GO:0007016)2.60750037
144positive regulation of epidermis development (GO:0045684)2.59879871
145wound healing, spreading of epidermal cells (GO:0035313)2.58692619
146mammary gland alveolus development (GO:0060749)2.58679291
147acylglycerol metabolic process (GO:0006639)2.57903491
148righting reflex (GO:0060013)2.56023582
149ventricular cardiac muscle cell action potential (GO:0086005)2.55354864
150retinal metabolic process (GO:0042574)2.55114695
151hair follicle development (GO:0001942)2.54609709
152neutral lipid metabolic process (GO:0006638)2.54000215
153regulation of clathrin-mediated endocytosis (GO:2000369)2.52367379
154skin development (GO:0043588)2.49643875
155retinol metabolic process (GO:0042572)2.49490162
156regulation of cell proliferation involved in kidney development (GO:1901722)2.46520068
157lipid particle organization (GO:0034389)2.44882667
158citrulline metabolic process (GO:0000052)2.44603132
159segment specification (GO:0007379)2.42256300
160hair cycle (GO:0042633)17.1217088
161molting cycle (GO:0042303)17.1217088
162keratinization (GO:0031424)10.6929830
163desmosome organization (GO:0002934)10.5027743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.10216679
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.60997462
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52601292
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.40244423
5* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.39382269
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.23633176
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.48979339
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.28947721
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.20639689
10TP63_17297297_ChIP-ChIP_HaCaT_Human12.7881748
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.94055198
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91544587
13ZNF263_19887448_ChIP-Seq_K562_Human1.78508551
14AR_21572438_ChIP-Seq_LNCaP_Human1.75721143
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.64714859
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64466845
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62672203
18RXR_22108803_ChIP-Seq_LS180_Human1.58333843
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58083913
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57085284
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53996175
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53996175
23CLOCK_20551151_ChIP-Seq_293T_Human1.53160537
24SOX2_20726797_ChIP-Seq_SW620_Human1.52679733
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.51361970
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.46789003
27GATA3_24758297_ChIP-Seq_MCF-7_Human1.45808892
28TP63_23658742_ChIP-Seq_EP156T_Human1.45282797
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44838898
30TP53_18474530_ChIP-ChIP_U2OS_Human1.42745092
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40395540
32TP63_22573176_ChIP-Seq_HFKS_Human1.38153619
33* GATA4_25053715_ChIP-Seq_YYC3_Human1.36451932
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36205290
35EGR1_19032775_ChIP-ChIP_M12_Human1.34766848
36* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32039153
37* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31571995
38* KLF5_25053715_ChIP-Seq_YYC3_Human1.31225275
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30710221
40CEBPB_22108803_ChIP-Seq_LS180_Human1.30296925
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28548303
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26679593
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25639710
44RACK7_27058665_Chip-Seq_MCF-7_Human1.22909388
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.21654924
46AHR_22903824_ChIP-Seq_MCF-7_Human1.21433053
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19562816
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18129801
49CJUN_26792858_Chip-Seq_BT549_Human1.14639917
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13699220
51ERG_20517297_ChIP-Seq_VCAP_Human1.12543013
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10087297
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09774220
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08953547
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.08835271
56AR_21909140_ChIP-Seq_LNCAP_Human1.08214443
57TAF2_19829295_ChIP-Seq_ESCs_Human1.07117103
58* ATF3_27146783_Chip-Seq_COLON_Human1.06864512
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.06380776
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04894318
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03788275
62CTCF_20526341_ChIP-Seq_ESCs_Human1.01562693
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.01416091
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00751868
65* P53_21459846_ChIP-Seq_SAOS-2_Human1.00484785
66BRD4_25478319_ChIP-Seq_HGPS_Human0.99967992
67* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99266575
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.99259281
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98053613
70BCAT_22108803_ChIP-Seq_LS180_Human0.97382490
71STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97214231
72TP53_16413492_ChIP-PET_HCT116_Human0.96836872
73TCF4_18268006_ChIP-ChIP_LS174T_Human0.95458434
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95268817
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94547418
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.93655886
77UBF1/2_26484160_Chip-Seq_HMECs_Human0.92631335
78P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92214500
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90840976
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.90403167
81E2F1_20622854_ChIP-Seq_HELA_Human0.89789795
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89765299
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86569481
84TCF4_22108803_ChIP-Seq_LS180_Human0.85663666
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85661794
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85268089
87JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84952721
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84596282
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84596282
90GATA6_25053715_ChIP-Seq_YYC3_Human0.84522585
91NANOG_20526341_ChIP-Seq_ESCs_Human0.84333093
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.83900343
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83822313
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83732390
95LXR_22292898_ChIP-Seq_THP-1_Human0.83278525
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.81796271
97CTCF_27219007_Chip-Seq_Bcells_Human0.81001358
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80933708
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.80544699
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.80544699
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79770243
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79570906
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78978507
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78416472
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77465345
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75748829
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.75591366
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74555094
109GATA3_21878914_ChIP-Seq_MCF-7_Human0.74539335
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73875941
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.72443208
112MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.71631781
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.71617308
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71583322
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71577418
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.71446211
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71328277
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71281403
119SA1_27219007_Chip-Seq_ERYTHROID_Human0.71246220
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.70492677
121SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70222648
122BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70222613
123* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69837649
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.68771928
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66407884
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.65271479
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63823718
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61967943
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.61112895
130* TP53_22127205_ChIP-Seq_IMR90_Human0.59565816
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.59444510
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.57864699
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.55176961
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.54687688
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.52860284
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.52584106
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.52506571
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.52421904
139RBPJ_21746931_ChIP-Seq_IB4_Human0.51127001
140SALL1_21062744_ChIP-ChIP_HESCs_Human0.48818315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.30496305
2MP0010234_abnormal_vibrissa_follicle5.57898951
3MP0005275_abnormal_skin_tensile5.57697069
4MP0000579_abnormal_nail_morphology5.12618885
5MP0005501_abnormal_skin_physiology4.39959279
6MP0002098_abnormal_vibrissa_morphology4.35295640
7MP0000647_abnormal_sebaceous_gland4.01405394
8MP0001881_abnormal_mammary_gland4.00843049
9MP0010678_abnormal_skin_adnexa3.68267755
10MP0000383_abnormal_hair_follicle3.65896323
11MP0004381_abnormal_hair_follicle3.29413809
12MP0002254_reproductive_system_inflammat3.26707109
13MP0000377_abnormal_hair_follicle3.07650508
14MP0003705_abnormal_hypodermis_morpholog2.98037781
15MP0001216_abnormal_epidermal_layer2.87403221
16MP0000427_abnormal_hair_cycle2.86197796
17MP0003941_abnormal_skin_development2.79142081
18MP0002060_abnormal_skin_morphology2.60666817
19MP0010771_integument_phenotype2.59882332
20MP0004947_skin_inflammation2.44420522
21MP0003011_delayed_dark_adaptation2.40906399
22MP0004185_abnormal_adipocyte_glucose2.19762415
23MP0003453_abnormal_keratinocyte_physiol2.09329387
24MP0005451_abnormal_body_composition2.06693453
25MP0002009_preneoplasia1.81586933
26MP0000367_abnormal_coat/_hair1.58776004
27MP0000627_abnormal_mammary_gland1.56807800
28MP0009931_abnormal_skin_appearance1.50923321
29MP0001243_abnormal_dermal_layer1.45338143
30MP0008260_abnormal_autophagy1.43891213
31MP0000467_abnormal_esophagus_morphology1.43668150
32MP0003136_yellow_coat_color1.38741006
33MP0004885_abnormal_endolymph1.35301301
34MP0008438_abnormal_cutaneous_collagen1.31687549
35MP0009379_abnormal_foot_pigmentation1.30641616
36MP0010368_abnormal_lymphatic_system1.30082052
37MP0000762_abnormal_tongue_morphology1.29004080
38MP0005666_abnormal_adipose_tissue1.27535950
39MP0000678_abnormal_parathyroid_gland1.27345943
40MP0003566_abnormal_cell_adhesion1.23705094
41MP0004019_abnormal_vitamin_homeostasis1.19822117
42MP0001191_abnormal_skin_condition1.17467949
43MP0005670_abnormal_white_adipose1.15568945
44MP0004130_abnormal_muscle_cell1.13375637
45MP0005248_abnormal_Harderian_gland1.10153321
46MP0003300_gastrointestinal_ulcer1.01446890
47MP0004264_abnormal_extraembryonic_tissu0.93660002
48MP0005375_adipose_tissue_phenotype0.90186247
49MP0005377_hearing/vestibular/ear_phenot0.87908030
50MP0003878_abnormal_ear_physiology0.87908030
51MP0001661_extended_life_span0.87449347
52MP0000537_abnormal_urethra_morphology0.85014800
53MP0002089_abnormal_postnatal_growth/wei0.84322079
54MP0002234_abnormal_pharynx_morphology0.83642310
55MP0003191_abnormal_cellular_cholesterol0.80970333
56MP0002166_altered_tumor_susceptibility0.77569726
57MP0009780_abnormal_chondrocyte_physiolo0.74403057
58MP0009384_cardiac_valve_regurgitation0.73627655
59MP0001851_eye_inflammation0.73363027
60MP0002970_abnormal_white_adipose0.72696467
61MP0000858_altered_metastatic_potential0.72013875
62MP0003950_abnormal_plasma_membrane0.70859215
63MP0005409_darkened_coat_color0.70627422
64MP0005623_abnormal_meninges_morphology0.68561925
65MP0002971_abnormal_brown_adipose0.67905018
66MP0001873_stomach_inflammation0.67544323
67MP0004147_increased_porphyrin_level0.67437970
68MP0003718_maternal_effect0.67235061
69MP0002006_tumorigenesis0.65610003
70MP0000566_synostosis0.65450167
71MP0001299_abnormal_eye_distance/0.64458962
72MP0001346_abnormal_lacrimal_gland0.64433431
73MP0001849_ear_inflammation0.63487894
74MP0001340_abnormal_eyelid_morphology0.62860237
75MP0005075_abnormal_melanosome_morpholog0.62191434
76MP0005083_abnormal_biliary_tract0.61091086
77MP0004782_abnormal_surfactant_physiolog0.59328274
78MP0000462_abnormal_digestive_system0.59211423
79MP0002877_abnormal_melanocyte_morpholog0.58814464
80MP0003091_abnormal_cell_migration0.58702647
81MP0000013_abnormal_adipose_tissue0.58443224
82MP0005360_urolithiasis0.57161836
83MP0005257_abnormal_intraocular_pressure0.56756461
84MP0005197_abnormal_uvea_morphology0.55284126
85MP0003315_abnormal_perineum_morphology0.54917627
86MP0010352_gastrointestinal_tract_polyps0.51306336
87MP0005193_abnormal_anterior_eye0.50253208
88MP0005023_abnormal_wound_healing0.49710880
89MP0004272_abnormal_basement_membrane0.49431862
90MP0001784_abnormal_fluid_regulation0.48540860
91MP0000470_abnormal_stomach_morphology0.46574706
92MP0000003_abnormal_adipose_tissue0.46341388
93MP0003303_peritoneal_inflammation0.45848957
94MP0002697_abnormal_eye_size0.45768284
95MP0001879_abnormal_lymphatic_vessel0.45315014
96MP0005164_abnormal_response_to0.44942664
97MP0009697_abnormal_copulation0.43093069
98MP0003828_pulmonary_edema0.42612886
99MP0000538_abnormal_urinary_bladder0.42519986
100MP0005076_abnormal_cell_differentiation0.42216642
101MP0002095_abnormal_skin_pigmentation0.41997243
102MP0000465_gastrointestinal_hemorrhage0.41380048
103MP0002118_abnormal_lipid_homeostasis0.40713066
104MP0000432_abnormal_head_morphology0.40575105
105MP0008004_abnormal_stomach_pH0.39815858
106MP0009053_abnormal_anal_canal0.39470798
107MP0001666_abnormal_nutrient_absorption0.38660693
108MP0005394_taste/olfaction_phenotype0.38383422
109MP0005499_abnormal_olfactory_system0.38383422
110MP0005395_other_phenotype0.37292523
111MP0004197_abnormal_fetal_growth/weight/0.36056884
112MP0002233_abnormal_nose_morphology0.35085089
113MP0003329_amyloid_beta_deposits0.34672727
114MP0004858_abnormal_nervous_system0.31485844
115MP0004134_abnormal_chest_morphology0.31480067
116MP0001765_abnormal_ion_homeostasis0.30897473
117MP0000750_abnormal_muscle_regeneration0.29278769
118MP0002282_abnormal_trachea_morphology0.29208786
119MP0003448_altered_tumor_morphology0.28766393
120MP0008789_abnormal_olfactory_epithelium0.27991242
121MP0005452_abnormal_adipose_tissue0.27971586
122MP0003385_abnormal_body_wall0.27733420
123MP0009840_abnormal_foam_cell0.26921307
124MP0001664_abnormal_digestion0.26388882
125MP0000751_myopathy0.24301692
126MP0002896_abnormal_bone_mineralization0.24146684
127MP0002111_abnormal_tail_morphology0.23639124
128MP0005334_abnormal_fat_pad0.22732232
129MP0000747_muscle_weakness0.22490355
130MP0002177_abnormal_outer_ear0.21633326
131MP0010329_abnormal_lipoprotein_level0.20494564
132MP0003936_abnormal_reproductive_system0.19553734
133MP0005085_abnormal_gallbladder_physiolo0.18636485
134MP0002090_abnormal_vision0.18302221
135MP0003755_abnormal_palate_morphology0.18249350
136MP0008770_decreased_survivor_rate0.17903617
137MP0000372_irregular_coat_pigmentation0.17006471
138MP0003045_fibrosis0.15659842
139MP0006054_spinal_hemorrhage0.15009080
140MP0002168_other_aberrant_phenotype0.14799440

Predicted human phenotypes

RankGene SetZ-score
1Woolly hair (HP:0002224)8.69224510
2Pili torti (HP:0003777)7.99380547
3Congenital ichthyosiform erythroderma (HP:0007431)7.15731338
4Abnormality of nail color (HP:0100643)7.10499472
5Ankyloglossia (HP:0010296)6.03686765
6Brittle hair (HP:0002299)5.77998922
7Slow-growing hair (HP:0002217)5.59716284
8Abnormality of hair growth rate (HP:0011363)5.59716284
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.30946163
10Increased IgE level (HP:0003212)5.21905824
11Right ventricular cardiomyopathy (HP:0011663)5.07873780
12Nail dystrophy (HP:0008404)5.04807469
13Abnormal hair laboratory examination (HP:0003328)5.02521026
14Onycholysis (HP:0001806)4.97290414
15Palmoplantar hyperkeratosis (HP:0000972)4.90950825
16Fragile nails (HP:0001808)4.84481141
17Abnormality of oral frenula (HP:0000190)4.72886604
18Plantar hyperkeratosis (HP:0007556)4.70678121
19Palmar hyperkeratosis (HP:0010765)4.60057159
20Erythroderma (HP:0001019)4.40012824
21Follicular hyperkeratosis (HP:0007502)4.34149774
22Parakeratosis (HP:0001036)4.29615755
23Alopecia of scalp (HP:0002293)4.26457091
24Thick nail (HP:0001805)4.08873364
25Ectropion (HP:0000656)4.03114149
26Erythema (HP:0010783)3.87411870
27Sparse eyelashes (HP:0000653)3.83859520
28Amelogenesis imperfecta (HP:0000705)3.82528058
29Congenital, generalized hypertrichosis (HP:0004540)3.71878347
30Curly hair (HP:0002212)3.69031809
31Milia (HP:0001056)3.40487499
32Pustule (HP:0200039)3.39820210
33Gangrene (HP:0100758)3.33864494
34Hypoplasia of dental enamel (HP:0006297)3.20585981
35Absent eyelashes (HP:0000561)3.17719512
36Lip pit (HP:0100267)3.16958485
37Corneal erosion (HP:0200020)3.14109933
38Conjunctival hamartoma (HP:0100780)3.08029661
39Hypohidrosis (HP:0000966)3.06663329
40Anonychia (HP:0001798)2.92929202
41Fine hair (HP:0002213)2.89185898
42Amniotic constriction ring (HP:0009775)2.85906262
43Abnormality of placental membranes (HP:0011409)2.85906262
44Abnormal blistering of the skin (HP:0008066)2.79702840
45Pruritus (HP:0000989)2.78490902
46Acanthosis nigricans (HP:0000956)2.72803372
47Palmoplantar keratoderma (HP:0000982)2.72322860
48Hyporeflexia of lower limbs (HP:0002600)2.72193991
49Natal tooth (HP:0000695)2.70255345
50Carious teeth (HP:0000670)2.66362620
51Oral leukoplakia (HP:0002745)2.65405056
52Advanced eruption of teeth (HP:0006288)2.61314812
53Aplasia cutis congenita (HP:0001057)2.59902891
54Poikiloderma (HP:0001029)2.58911444
55Lack of skin elasticity (HP:0100679)2.47191609
56Popliteal pterygium (HP:0009756)2.42916286
57Xerostomia (HP:0000217)2.40946323
58Selective tooth agenesis (HP:0001592)2.39729149
59Hyperhidrosis (HP:0000975)2.39709713
60Type 1 muscle fiber predominance (HP:0003803)2.34856093
61Trismus (HP:0000211)2.34219106
62Absent hair (HP:0002298)2.34203448
63Cheilitis (HP:0100825)2.30847539
64Abnormality of the salivary glands (HP:0010286)2.29375566
65Thin bony cortex (HP:0002753)2.28189546
66Arterial tortuosity (HP:0005116)2.26764411
67Hypoplastic labia majora (HP:0000059)2.26414866
68Neck muscle weakness (HP:0000467)2.26188921
69Axonal loss (HP:0003447)2.25780302
70Concave nail (HP:0001598)2.23198751
71Abnormality of the fingernails (HP:0001231)2.20743144
72Oligodontia (HP:0000677)2.18707983
73Ventricular tachycardia (HP:0004756)2.17317634
74Laryngomalacia (HP:0001601)2.16546837
75Abnormality of the axillary hair (HP:0100134)2.11100557
76Abnormality of secondary sexual hair (HP:0009888)2.11100557
77Abnormality of purine metabolism (HP:0004352)2.08507933
78Dry hair (HP:0011359)2.06524164
79Periodontitis (HP:0000704)2.05395043
80Abnormality of the dental pulp (HP:0006479)2.00823536
81Atrophic scars (HP:0001075)2.00253855
82Hypotrichosis (HP:0001006)10.2629736
83Hypodontia (HP:0000668)1.98945022
84Ridged nail (HP:0001807)1.97515648
85Sparse scalp hair (HP:0002209)1.92870677
86Vascular tortuosity (HP:0004948)1.90097541
87Myopathic facies (HP:0002058)1.87615699
88Increased connective tissue (HP:0009025)1.87566404
89Corneal dystrophy (HP:0001131)1.82633287
90Hamartoma of the eye (HP:0010568)1.82499712
91Malignant hyperthermia (HP:0002047)1.81558124
92Neurofibrillary tangles (HP:0002185)1.81063578
93Dehydration (HP:0001944)1.80896477
94Distal arthrogryposis (HP:0005684)1.79457640
95Abnormality of dental color (HP:0011073)1.78868054
96Ventricular fibrillation (HP:0001663)1.78231017
97Skin ulcer (HP:0200042)1.78174589
98Widely patent fontanelles and sutures (HP:0004492)1.76501480
99Round ear (HP:0100830)1.76149820
100Distal lower limb muscle weakness (HP:0009053)1.75016932
101Abnormality of the neuromuscular junction (HP:0003398)1.72639169
102Fatigable weakness (HP:0003473)1.72639169
103Abnormality of the frontal sinuses (HP:0002687)1.69680840
104Short nail (HP:0001799)1.64937379
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64306604
106Blepharitis (HP:0000498)1.63516499
107Furrowed tongue (HP:0000221)1.62965589
108Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61498418
109Fragile skin (HP:0001030)1.60988046
110Neonatal death (HP:0003811)1.60120040
111Autoamputation (HP:0001218)1.59731470
112Muscle fiber inclusion bodies (HP:0100299)1.59242084
113Nemaline bodies (HP:0003798)1.58876204
114Intention tremor (HP:0002080)1.57564822
115Stridor (HP:0010307)1.56688892
116Pterygium (HP:0001059)1.56212256
117Difficulty walking (HP:0002355)1.55375816
118Abnormality of molar morphology (HP:0011070)1.54710417
119Abnormality of molar (HP:0011077)1.54710417
120Multifactorial inheritance (HP:0001426)1.53923707
121Premature loss of primary teeth (HP:0006323)1.53623377
122Abnormality of the labia majora (HP:0012881)1.51898784
123Urticaria (HP:0001025)1.51713219
124Abnormality of permanent molar morphology (HP:0011071)1.51231702
125Abnormality of the dental root (HP:0006486)1.51231702
126Taurodontia (HP:0000679)1.51231702
127Recurrent corneal erosions (HP:0000495)1.50885935
128Overgrowth (HP:0001548)1.50364976
129Ulnar deviation of the wrist (HP:0003049)1.45896821
130Breast hypoplasia (HP:0003187)1.45014305
131Abnormalities of placenta or umbilical cord (HP:0001194)1.44975047
132Subcapsular cataract (HP:0000523)1.43294515
133Hypergammaglobulinemia (HP:0010702)1.41900340
134Areflexia of lower limbs (HP:0002522)1.41756723
135Ankle contracture (HP:0006466)1.41624233
136Osteolytic defects of the hand bones (HP:0009699)1.39551136
137Abnormality of the gastric mucosa (HP:0004295)1.39416980
138Septate vagina (HP:0001153)1.38891680
139Labial hypoplasia (HP:0000066)1.37087700
140Hoarse voice (HP:0001609)1.34364861
141Hypoplastic toenails (HP:0001800)1.33963818
142Cerebral inclusion bodies (HP:0100314)1.33940931
143Split foot (HP:0001839)1.33560414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.51153261
2MAP3K94.36882023
3SIK14.17637908
4ARAF3.59832044
5MAPKAPK33.58305151
6TRIB33.52141874
7CAMK1G3.24492771
8LMTK22.98595043
9ERN12.96823339
10PKN22.88946602
11EEF2K2.84496377
12NTRK12.83140267
13FER2.76714604
14MST1R2.59321233
15LATS12.57177883
16TGFBR12.37290470
17FLT32.16428052
18STK38L2.10578514
19PIK3CG1.98517085
20MAP3K61.93797691
21PDK41.85840496
22PDK31.85840496
23PTK61.82507783
24BCKDK1.82032183
25MAP3K21.81863053
26TRPM71.81031119
27MAP3K31.73476696
28MAP3K71.72581825
29MAP3K131.58690581
30RPS6KB21.56390490
31RIPK11.54725777
32NME21.48337051
33PRKAA21.45180042
34BCR1.39970122
35KSR21.39288593
36TGFBR21.35524026
37CDK61.31736534
38MOS1.30326188
39LRRK21.28227605
40EPHB21.27775552
41DDR21.20029845
42PAK41.17283478
43EPHA21.15185732
44TESK11.12763342
45PDK21.11606486
46MST41.08862643
47FGFR11.07066730
48TAOK11.06827362
49MAP2K61.05199240
50STK381.04610801
51FRK1.04467445
52PDGFRB1.03717263
53BRAF1.01653927
54FGFR20.89516327
55LATS20.89303807
56PDGFRA0.88909935
57EPHB10.86804957
58CDK120.86554506
59MAP3K120.84073557
60MAP3K110.83999066
61TTN0.83543682
62MAPKAPK50.79678958
63CDK90.78102751
64EPHA30.76572982
65STK30.76504576
66RET0.76502669
67FGFR30.76251876
68RAF10.74961808
69IRAK30.74878188
70MET0.74230486
71MAP2K40.72045158
72MAPK120.71541635
73STK240.70683767
74OBSCN0.68144564
75TYRO30.66531764
76PHKG20.66130014
77PHKG10.66130014
78PRKD20.64048044
79KSR10.62519292
80SIK30.60647125
81ILK0.58995223
82ROCK20.58672594
83PIK3CA0.58396421
84JAK10.56340238
85PTK20.56137055
86FGFR40.55962556
87TNK20.55144771
88PRKAA10.54955712
89AKT30.54006051
90SGK4940.53842508
91SGK2230.53842508
92IKBKB0.53755189
93CSF1R0.53442605
94MAP2K10.52346415
95BMX0.51647278
96ITK0.51567798
97DYRK1B0.51548448
98ABL20.51289207
99WNK10.50367838
100ERBB40.49489188
101MAP3K10.49455299
102NUAK10.48640185
103ERBB30.47696194
104NME10.47480505
105TESK20.46074414
106JAK30.45532432
107PRKD10.45522895
108GSK3A0.43962316
109STK100.43836078
110MAPKAPK20.43805943
111ADRBK10.42552865
112DMPK0.41872632
113SGK30.40518051
114RPS6KA20.40377456
115STK110.40319518
116PRKCE0.40162540
117FGR0.40104844
118PBK0.37493854
119MAP3K140.37103279
120LIMK10.36304671
121EIF2AK20.36098365
122JAK20.35365223
123NEK60.33791601
124PRKCI0.32663772
125RPS6KA40.31561305
126PTK2B0.31433105
127MARK20.30549134
128MAP3K50.29799453
129PDPK10.29128008
130MARK30.28710247
131STK390.28225450
132CDK30.27561173
133BLK0.27382471
134MTOR0.27243701
135MAPK110.26739622
136ERBB20.25377720
137RPS6KB10.24492502
138ZAP700.24304470
139PRKG20.23490147
140PIM20.23015135
141WNK40.22957634
142MAP3K80.22649540
143ABL10.22040478
144BMPR20.21837987
145ROCK10.20984894
146IGF1R0.20433339
147PAK20.19677274
148INSR0.19162299
149SRC0.15858078
150SCYL20.14076918
151TSSK60.13640719

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.97791756
2Caffeine metabolism_Homo sapiens_hsa002325.54546984
3Fatty acid elongation_Homo sapiens_hsa000624.38976329
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.07247733
5Fatty acid metabolism_Homo sapiens_hsa012123.48199167
6Small cell lung cancer_Homo sapiens_hsa052223.14310420
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.79647959
8Steroid biosynthesis_Homo sapiens_hsa001002.79113166
9Propanoate metabolism_Homo sapiens_hsa006402.61967442
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59738612
11PPAR signaling pathway_Homo sapiens_hsa033202.13162431
12Linoleic acid metabolism_Homo sapiens_hsa005912.07454807
13Malaria_Homo sapiens_hsa051441.99228254
14p53 signaling pathway_Homo sapiens_hsa041151.91361929
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78918445
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72224394
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67223524
18Fat digestion and absorption_Homo sapiens_hsa049751.58913642
19Prion diseases_Homo sapiens_hsa050201.58566176
20Pyruvate metabolism_Homo sapiens_hsa006201.52292333
21Fatty acid degradation_Homo sapiens_hsa000711.48646117
22Sphingolipid metabolism_Homo sapiens_hsa006001.44484577
23Galactose metabolism_Homo sapiens_hsa000521.36077475
24Hematopoietic cell lineage_Homo sapiens_hsa046401.33167076
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32311632
26Arachidonic acid metabolism_Homo sapiens_hsa005901.24106170
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23227405
28Prolactin signaling pathway_Homo sapiens_hsa049171.22698327
29Pathways in cancer_Homo sapiens_hsa052001.21110027
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20102933
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15983803
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15838686
33Salmonella infection_Homo sapiens_hsa051321.15703087
34Renal cell carcinoma_Homo sapiens_hsa052111.13243875
35Retinol metabolism_Homo sapiens_hsa008301.11771965
36Histidine metabolism_Homo sapiens_hsa003401.07271088
37Dilated cardiomyopathy_Homo sapiens_hsa054141.05428360
38Long-term depression_Homo sapiens_hsa047301.05010499
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02761001
40Chronic myeloid leukemia_Homo sapiens_hsa052201.00199962
41beta-Alanine metabolism_Homo sapiens_hsa004100.99985206
42Ether lipid metabolism_Homo sapiens_hsa005650.99576683
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99009538
44Shigellosis_Homo sapiens_hsa051310.96512610
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93768312
46TGF-beta signaling pathway_Homo sapiens_hsa043500.92323059
47Inositol phosphate metabolism_Homo sapiens_hsa005620.92204999
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.91906209
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.91662776
50Peroxisome_Homo sapiens_hsa041460.89949539
51ABC transporters_Homo sapiens_hsa020100.88540627
52Phenylalanine metabolism_Homo sapiens_hsa003600.86251423
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84677344
54Mineral absorption_Homo sapiens_hsa049780.83670851
55Glycerolipid metabolism_Homo sapiens_hsa005610.82728506
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82725410
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79901225
58VEGF signaling pathway_Homo sapiens_hsa043700.79483558
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78291477
60Ribosome_Homo sapiens_hsa030100.77886978
61Tight junction_Homo sapiens_hsa045300.76527022
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74241730
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71516743
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71504433
65TNF signaling pathway_Homo sapiens_hsa046680.70542869
66Adherens junction_Homo sapiens_hsa045200.68076533
67ECM-receptor interaction_Homo sapiens_hsa045120.66178308
68Ovarian steroidogenesis_Homo sapiens_hsa049130.66053820
69Insulin resistance_Homo sapiens_hsa049310.65729928
70Endocytosis_Homo sapiens_hsa041440.65400508
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64535599
72AMPK signaling pathway_Homo sapiens_hsa041520.63373034
73Vitamin digestion and absorption_Homo sapiens_hsa049770.62245477
74Choline metabolism in cancer_Homo sapiens_hsa052310.61783120
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60925671
76Serotonergic synapse_Homo sapiens_hsa047260.60498998
77Butanoate metabolism_Homo sapiens_hsa006500.58068446
78Renin secretion_Homo sapiens_hsa049240.52839952
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.52254908
80Dorso-ventral axis formation_Homo sapiens_hsa043200.51453946
81Pertussis_Homo sapiens_hsa051330.50864193
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50860792
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.50820596
84Pancreatic secretion_Homo sapiens_hsa049720.50775441
85Carbon metabolism_Homo sapiens_hsa012000.50544498
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49855049
87Tyrosine metabolism_Homo sapiens_hsa003500.49810646
88GnRH signaling pathway_Homo sapiens_hsa049120.49638668
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.48436806
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48366773
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48321396
92Endometrial cancer_Homo sapiens_hsa052130.47610319
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46359313
94Sulfur metabolism_Homo sapiens_hsa009200.45446390
95Bladder cancer_Homo sapiens_hsa052190.45432093
96Basal cell carcinoma_Homo sapiens_hsa052170.45297129
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.45215582
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44488813
99Hepatitis C_Homo sapiens_hsa051600.44327979
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43642853
101Rap1 signaling pathway_Homo sapiens_hsa040150.41220477
102Proteoglycans in cancer_Homo sapiens_hsa052050.39091176
103Melanoma_Homo sapiens_hsa052180.38446230
104Rheumatoid arthritis_Homo sapiens_hsa053230.38373955
105Prostate cancer_Homo sapiens_hsa052150.38191261
106Estrogen signaling pathway_Homo sapiens_hsa049150.37558135
107Non-small cell lung cancer_Homo sapiens_hsa052230.36476356
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.35307917
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35243378
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34287220
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.33828257
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33687930
113Insulin signaling pathway_Homo sapiens_hsa049100.33022531
114Apoptosis_Homo sapiens_hsa042100.32856838
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31350482
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31273765
117HIF-1 signaling pathway_Homo sapiens_hsa040660.31012623
118Hippo signaling pathway_Homo sapiens_hsa043900.30667607
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30140715
120MAPK signaling pathway_Homo sapiens_hsa040100.30087893
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.29182897
122Amoebiasis_Homo sapiens_hsa051460.28678036
123Glucagon signaling pathway_Homo sapiens_hsa049220.27990163
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.27676159
125ErbB signaling pathway_Homo sapiens_hsa040120.26989863
126Chemical carcinogenesis_Homo sapiens_hsa052040.26771390
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26094315
128Acute myeloid leukemia_Homo sapiens_hsa052210.25972130
129Pentose phosphate pathway_Homo sapiens_hsa000300.25617453
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23779885
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23616055
132Toxoplasmosis_Homo sapiens_hsa051450.23250194
133Circadian rhythm_Homo sapiens_hsa047100.22306449
134Focal adhesion_Homo sapiens_hsa045100.22054635
135Thyroid cancer_Homo sapiens_hsa052160.21985422
136Protein digestion and absorption_Homo sapiens_hsa049740.21585723
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21146415
138Gastric acid secretion_Homo sapiens_hsa049710.20309193
139Glutathione metabolism_Homo sapiens_hsa004800.19657024
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19473388
141Axon guidance_Homo sapiens_hsa043600.18505868
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18439343
143Melanogenesis_Homo sapiens_hsa049160.18223916
144Folate biosynthesis_Homo sapiens_hsa007900.17052234
145Pancreatic cancer_Homo sapiens_hsa052120.16594893
146Staphylococcus aureus infection_Homo sapiens_hsa051500.14690354
147Ras signaling pathway_Homo sapiens_hsa040140.14533891
148Glioma_Homo sapiens_hsa052140.14355255
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.14288481
150mTOR signaling pathway_Homo sapiens_hsa041500.13082527
151Platelet activation_Homo sapiens_hsa046110.13063641
152MicroRNAs in cancer_Homo sapiens_hsa052060.12790015

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