HERC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.20115118
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.81787749
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46484134
4locomotory exploration behavior (GO:0035641)4.45614051
5histone H3-K36 demethylation (GO:0070544)4.28076471
6synaptic vesicle maturation (GO:0016188)4.26674155
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20420665
8positive regulation of gamma-delta T cell activation (GO:0046645)4.19643552
9vocalization behavior (GO:0071625)4.12552179
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03929047
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.00485509
12synaptic vesicle exocytosis (GO:0016079)3.95665750
13regulation of glutamate receptor signaling pathway (GO:1900449)3.93388677
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.92077413
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90126777
16regulation of synaptic vesicle exocytosis (GO:2000300)3.85793009
17protein localization to synapse (GO:0035418)3.80607572
18regulation of B cell receptor signaling pathway (GO:0050855)3.78596337
19interkinetic nuclear migration (GO:0022027)3.73607309
20glutamate receptor signaling pathway (GO:0007215)3.68116301
21* cerebellar Purkinje cell differentiation (GO:0021702)3.67898124
22neuron cell-cell adhesion (GO:0007158)3.65204804
23glutamate secretion (GO:0014047)3.58581941
24cellular response to ethanol (GO:0071361)3.58014952
25positive T cell selection (GO:0043368)3.57724935
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56236512
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55933970
28regulation of gamma-delta T cell differentiation (GO:0045586)3.51235808
29regulation of ARF protein signal transduction (GO:0032012)3.50709487
30synaptic vesicle endocytosis (GO:0048488)3.49729864
31layer formation in cerebral cortex (GO:0021819)3.48262031
32synaptic transmission, glutamatergic (GO:0035249)3.42140669
33regulation of synaptic vesicle transport (GO:1902803)3.39668014
34neurotransmitter secretion (GO:0007269)3.39290139
35B cell receptor signaling pathway (GO:0050853)3.38512905
36sodium ion export (GO:0071436)3.35091124
37exploration behavior (GO:0035640)3.34919558
38cellular potassium ion homeostasis (GO:0030007)3.31098143
39histone H3-K9 demethylation (GO:0033169)3.29895686
40membrane depolarization during action potential (GO:0086010)3.28358502
41nucleus localization (GO:0051647)3.27345144
42positive regulation of granulocyte differentiation (GO:0030854)3.26724976
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24959043
44regulation of gamma-delta T cell activation (GO:0046643)3.24403488
45proline transport (GO:0015824)3.24254026
46monoubiquitinated protein deubiquitination (GO:0035520)3.23258102
47neurotransmitter-gated ion channel clustering (GO:0072578)3.21650437
48vesicle transport along microtubule (GO:0047496)3.21377425
49neuron-neuron synaptic transmission (GO:0007270)3.20335988
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15001529
51regulation of neuronal synaptic plasticity (GO:0048168)3.14463735
52long-term memory (GO:0007616)3.14413344
53positive regulation of synapse maturation (GO:0090129)3.13178461
54establishment of nucleus localization (GO:0040023)3.12520007
55regulation of synapse structural plasticity (GO:0051823)3.12177487
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11580951
57regulation of postsynaptic membrane potential (GO:0060078)3.11330311
58neuronal action potential propagation (GO:0019227)3.10833001
59innervation (GO:0060384)3.08614725
60histone lysine demethylation (GO:0070076)3.08536088
61negative T cell selection (GO:0043383)3.08416859
62negative thymic T cell selection (GO:0045060)3.07734523
63peptidyl-lysine trimethylation (GO:0018023)3.05624031
64dendrite morphogenesis (GO:0048813)3.04214124
65establishment of protein localization to Golgi (GO:0072600)3.02687478
66axonal fasciculation (GO:0007413)3.02218900
67histone H3-K4 trimethylation (GO:0080182)3.01619021
68protein targeting to Golgi (GO:0000042)3.01432434
69positive regulation of Rap GTPase activity (GO:0032854)3.01183733
70dendritic spine morphogenesis (GO:0060997)3.00530226
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99772236
72neuron recognition (GO:0008038)2.99199325
73histone demethylation (GO:0016577)2.97667977
74activation of protein kinase A activity (GO:0034199)2.96932095
75positive thymic T cell selection (GO:0045059)2.96706122
76activated T cell proliferation (GO:0050798)2.96430064
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95441655
78positive regulation of dendritic spine morphogenesis (GO:0061003)2.94477968
79regulation of dendritic spine morphogenesis (GO:0061001)2.93136839
80lipid translocation (GO:0034204)2.93110168
81phospholipid translocation (GO:0045332)2.93110168
82gamma-aminobutyric acid transport (GO:0015812)2.91760893
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.90715173
84Golgi to endosome transport (GO:0006895)2.89378988
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88847374
86prepulse inhibition (GO:0060134)2.88597052
87regulation of Rap GTPase activity (GO:0032317)2.87991126
88cellular response to epinephrine stimulus (GO:0071872)2.86684761
89protein K48-linked deubiquitination (GO:0071108)2.86077109
90long-term synaptic potentiation (GO:0060291)2.84063742
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.83994539
92regulation of neurotransmitter secretion (GO:0046928)2.83419069
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81790369
94membrane depolarization (GO:0051899)2.81645285
95presynaptic membrane assembly (GO:0097105)2.77775223
96peptidyl-threonine phosphorylation (GO:0018107)2.77453762
97cell communication by electrical coupling (GO:0010644)2.75818373
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75774191
99macroautophagy (GO:0016236)2.75047264
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74679346
101negative regulation of cell killing (GO:0031342)2.74679346
102histone H3-K9 modification (GO:0061647)2.74301038
103skeletal muscle adaptation (GO:0043501)2.73936777
104striatum development (GO:0021756)2.72488500
105protein K11-linked deubiquitination (GO:0035871)2.71530705
106myofibril assembly (GO:0030239)2.70446865
107positive regulation of membrane potential (GO:0045838)2.69552295
108transmission of nerve impulse (GO:0019226)2.69140742
109neurotransmitter transport (GO:0006836)2.68875037
110cellular extravasation (GO:0045123)2.68621563
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68510296
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67635880
113negative regulation of translation, ncRNA-mediated (GO:0040033)2.67635880
114regulation of translation, ncRNA-mediated (GO:0045974)2.67635880
115histone H3-K4 methylation (GO:0051568)2.67299695
116organelle transport along microtubule (GO:0072384)2.66468554
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64113449
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63782450
119regulation of synaptic plasticity (GO:0048167)2.63616135
120T cell selection (GO:0045058)2.62901947
121response to histamine (GO:0034776)2.61010912
122cell migration in hindbrain (GO:0021535)2.60726494
123regulation of NFAT protein import into nucleus (GO:0051532)2.60373649
124regulation of synapse maturation (GO:0090128)2.59732157
125presynaptic membrane organization (GO:0097090)2.59198602
126negative regulation of inclusion body assembly (GO:0090084)2.58458663
127synapse assembly (GO:0007416)2.58097493
128protein demethylation (GO:0006482)2.57376483
129protein dealkylation (GO:0008214)2.57376483
130membrane hyperpolarization (GO:0060081)2.56705366
131negative regulation of erythrocyte differentiation (GO:0045647)2.56577969
132definitive hemopoiesis (GO:0060216)2.56490359
133nerve growth factor signaling pathway (GO:0038180)2.56301639
134peptidyl-lysine methylation (GO:0018022)2.55890722
135protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.55733643
136histone lysine methylation (GO:0034968)2.55722987
137clathrin coat assembly (GO:0048268)2.55226279
138neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.55091161
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54607256
140positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54284819
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54020039
142response to epinephrine (GO:0071871)2.54018791
143regulation of protein polyubiquitination (GO:1902914)2.52810051
144postsynaptic membrane organization (GO:0001941)2.52536589
145stress granule assembly (GO:0034063)2.52407140
146cytoplasmic mRNA processing body assembly (GO:0033962)2.51410030
147peptidyl-threonine modification (GO:0018210)2.50583075
148detection of calcium ion (GO:0005513)2.50318401
149regulation of neurotransmitter transport (GO:0051588)2.50154245
150positive regulation of neurotransmitter secretion (GO:0001956)2.50028060
151regulation of clathrin-mediated endocytosis (GO:2000369)2.49574941
152G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49326769
153regulation of dendritic spine development (GO:0060998)2.48361027
154regulation of beta-amyloid formation (GO:1902003)2.47718117
155striated muscle atrophy (GO:0014891)2.47093733
156negative regulation of neurotransmitter transport (GO:0051589)2.44454913
157germinal center formation (GO:0002467)2.43610934
158sarcoplasmic reticulum calcium ion transport (GO:0070296)2.43410515
159regulation of skeletal muscle cell differentiation (GO:2001014)2.41225264
160protein K63-linked deubiquitination (GO:0070536)2.40127431
161response to interleukin-15 (GO:0070672)2.37919966
162histone H3-K9 methylation (GO:0051567)2.36412889
163dosage compensation (GO:0007549)2.35773775
164regulation of relaxation of muscle (GO:1901077)2.35490470
165regulation of granulocyte differentiation (GO:0030852)2.35121526
166cardiac muscle hypertrophy (GO:0003300)2.33972102
167peptidyl-serine phosphorylation (GO:0018105)2.33237149
168positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32365285
169thymic T cell selection (GO:0045061)2.32246792
170regulation of histone H3-K27 methylation (GO:0061085)2.30852208
171microglial cell activation (GO:0001774)2.30560223
172growth hormone receptor signaling pathway (GO:0060396)2.28811572
173negative regulation of neurotransmitter secretion (GO:0046929)2.27811028
174phosphatidylinositol phosphorylation (GO:0046854)2.26737371
175insulin-like growth factor receptor signaling pathway (GO:0048009)2.25690884
176regulation of pigment cell differentiation (GO:0050932)2.25209255
177negative regulation of T cell mediated immunity (GO:0002710)2.23661689
178hepatocyte apoptotic process (GO:0097284)2.22320120
179cellular response to monoamine stimulus (GO:0071868)2.21762655
180cellular response to catecholamine stimulus (GO:0071870)2.21762655
181histone mRNA catabolic process (GO:0071044)2.21515392
182striated muscle hypertrophy (GO:0014897)2.20314270
183striated muscle adaptation (GO:0014888)2.18510887
184negative regulation of dendrite morphogenesis (GO:0050774)2.17537964
185positive regulation of B cell differentiation (GO:0045579)2.17285134
186regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.16252810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67246204
2GBX2_23144817_ChIP-Seq_PC3_Human3.68430709
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10164698
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50823688
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44927852
6SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39841686
7DROSHA_22980978_ChIP-Seq_HELA_Human2.37433804
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30584643
9RUNX_20019798_ChIP-Seq_JUKART_Human2.19270131
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18129136
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14219261
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10702965
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.09808136
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.04793598
15SCL_19346495_ChIP-Seq_HPC-7_Human1.97550096
16* SMAD4_21799915_ChIP-Seq_A2780_Human1.93066090
17AR_21572438_ChIP-Seq_LNCaP_Human1.88439050
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86032435
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80516716
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77100741
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77100741
22* IRF8_22096565_ChIP-ChIP_GC-B_Human1.75512836
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75475934
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74778258
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74592061
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73618127
27TAF15_26573619_Chip-Seq_HEK293_Human1.73056113
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71411819
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70686348
30STAT3_23295773_ChIP-Seq_U87_Human1.67142570
31* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67077447
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65680313
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65674435
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63442125
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.62335640
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.61757489
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61317848
38TP53_16413492_ChIP-PET_HCT116_Human1.61001386
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60254216
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59867008
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57214947
42* SMAD_19615063_ChIP-ChIP_OVARY_Human1.56315778
43P300_19829295_ChIP-Seq_ESCs_Human1.55239415
44* TCF4_23295773_ChIP-Seq_U87_Human1.54909715
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54577697
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54556502
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53816193
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52702209
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.51771291
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51673086
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.48950267
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.48050037
53AHR_22903824_ChIP-Seq_MCF-7_Human1.46266695
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.45140943
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.42613796
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.41552423
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41479797
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40680326
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.40530143
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40454328
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39566047
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39379797
63* GATA1_19941826_ChIP-Seq_K562_Human1.38267118
64GATA1_22025678_ChIP-Seq_K562_Human1.37871801
65AR_19668381_ChIP-Seq_PC3_Human1.37535605
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.36694981
67IGF1R_20145208_ChIP-Seq_DFB_Human1.36605563
68AR_25329375_ChIP-Seq_VCAP_Human1.35735431
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35639916
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35218154
71* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33661194
72VDR_24787735_ChIP-Seq_THP-1_Human1.33107724
73* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32816438
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32004722
75* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31980599
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30588423
77* GATA2_19941826_ChIP-Seq_K562_Human1.28751838
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28403756
79FUS_26573619_Chip-Seq_HEK293_Human1.27875606
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26372021
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25965878
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25551422
83SPI1_23127762_ChIP-Seq_K562_Human1.25385549
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24998003
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23837445
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23837445
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.22671334
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22423271
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21592431
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.21302997
91ZNF274_21170338_ChIP-Seq_K562_Hela1.21256694
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.19659518
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19576729
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19330258
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18756350
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.16476700
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15910495
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15906006
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14385968
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13406196
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12271546
102RUNX2_22187159_ChIP-Seq_PCA_Human1.11915929
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09722776
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.09559417
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09403952
106BCAT_22108803_ChIP-Seq_LS180_Human1.07198504
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07059438
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06780564
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.06356703
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05980628
111* SMAD3_21741376_ChIP-Seq_ESCs_Human1.05723807
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.05574843
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05374604
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05248776
115MYB_26560356_Chip-Seq_TH2_Human1.04748065
116* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03690893
117ER_23166858_ChIP-Seq_MCF-7_Human1.02659974
118KDM2B_26808549_Chip-Seq_REH_Human1.01283288
119* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00621076
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00258204
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99857108
122GATA3_27048872_Chip-Seq_THYMUS_Human0.99282395
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.98510377
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98425441
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98035179
126* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97243789
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.97057802
128RNF2_27304074_Chip-Seq_NSC_Mouse0.96942722
129* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96203801
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.96053690
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.95832538
132EWS_26573619_Chip-Seq_HEK293_Human0.94689763
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.94610982
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94579548
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93927410
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93212225
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93212225
138* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92775366
139* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92668881
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92555350
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92204726
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91390893
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.91260631
144TCF7_22412390_ChIP-Seq_EML_Mouse0.90870235
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90693523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42404604
2MP0000569_abnormal_digit_pigmentation5.14649550
3MP0003880_abnormal_central_pattern3.61223103
4MP0003635_abnormal_synaptic_transmissio3.51691803
5MP0003787_abnormal_imprinting3.45593115
6MP0008057_abnormal_DNA_replication3.36159993
7MP0004270_analgesia3.10122772
8MP0009046_muscle_twitch2.96687448
9MP0009745_abnormal_behavioral_response2.87094643
10MP0002063_abnormal_learning/memory/cond2.82528771
11MP0003763_abnormal_thymus_physiology2.79218409
12MP0004130_abnormal_muscle_cell2.72197057
13MP0005423_abnormal_somatic_nervous2.65123899
14MP0002064_seizures2.56341437
15MP0001968_abnormal_touch/_nociception2.49362125
16MP0002572_abnormal_emotion/affect_behav2.39114628
17MP0002734_abnormal_mechanical_nocicepti2.28338507
18MP0001486_abnormal_startle_reflex2.25837857
19MP0003646_muscle_fatigue2.25460206
20MP0004036_abnormal_muscle_relaxation2.18755427
21MP0003656_abnormal_erythrocyte_physiolo2.15458326
22MP0009780_abnormal_chondrocyte_physiolo2.15344319
23MP0002735_abnormal_chemical_nociception2.11625855
24MP0002272_abnormal_nervous_system2.06523460
25MP0004084_abnormal_cardiac_muscle2.03457846
26MP0008877_abnormal_DNA_methylation1.93385257
27* MP0002067_abnormal_sensory_capabilities1.92172260
28MP0001501_abnormal_sleep_pattern1.85648692
29MP0008569_lethality_at_weaning1.85599914
30MP0002332_abnormal_exercise_endurance1.84803116
31MP0000778_abnormal_nervous_system1.84001418
32MP0005451_abnormal_body_composition1.82345234
33MP0003303_peritoneal_inflammation1.81619213
34MP0002166_altered_tumor_susceptibility1.81558165
35MP0003828_pulmonary_edema1.80857938
36MP0001440_abnormal_grooming_behavior1.78545949
37MP0002736_abnormal_nociception_after1.75740704
38MP0005645_abnormal_hypothalamus_physiol1.74352962
39MP0002184_abnormal_innervation1.72438269
40MP0004381_abnormal_hair_follicle1.72291771
41MP0004924_abnormal_behavior1.72015122
42MP0005386_behavior/neurological_phenoty1.72015122
43MP0004811_abnormal_neuron_physiology1.71412588
44MP0003690_abnormal_glial_cell1.68403553
45MP0002557_abnormal_social/conspecific_i1.64869190
46MP0001984_abnormal_olfaction1.64560543
47MP0005646_abnormal_pituitary_gland1.64362879
48MP0002822_catalepsy1.61253617
49MP0002909_abnormal_adrenal_gland1.60210812
50MP0003724_increased_susceptibility_to1.57334559
51MP0002733_abnormal_thermal_nociception1.57238765
52MP0000749_muscle_degeneration1.55162348
53MP0003121_genomic_imprinting1.50807471
54MP0001970_abnormal_pain_threshold1.47281714
55MP0008260_abnormal_autophagy1.46861067
56MP0003122_maternal_imprinting1.43931009
57MP0000955_abnormal_spinal_cord1.42425154
58MP0001188_hyperpigmentation1.41393256
59MP0003221_abnormal_cardiomyocyte_apopto1.39422702
60MP0005551_abnormal_eye_electrophysiolog1.38441538
61MP0001835_abnormal_antigen_presentation1.34686167
62MP0004808_abnormal_hematopoietic_stem1.34617264
63MP0003045_fibrosis1.32240088
64MP0001502_abnormal_circadian_rhythm1.32154824
65MP0006276_abnormal_autonomic_nervous1.31541032
66MP0001800_abnormal_humoral_immune1.30413051
67MP0003633_abnormal_nervous_system1.28918080
68* MP0002882_abnormal_neuron_morphology1.27654921
69MP0003183_abnormal_peptide_metabolism1.27576789
70MP0005310_abnormal_salivary_gland1.25440720
71MP0003091_abnormal_cell_migration1.23049663
72MP0002396_abnormal_hematopoietic_system1.22971352
73MP0000015_abnormal_ear_pigmentation1.22006225
74MP0004087_abnormal_muscle_fiber1.21570609
75MP0002106_abnormal_muscle_physiology1.17107089
76MP0008961_abnormal_basal_metabolism1.16419178
77MP0004858_abnormal_nervous_system1.14993294
78MP0000703_abnormal_thymus_morphology1.14027324
79MP0003879_abnormal_hair_cell1.13231153
80MP0002398_abnormal_bone_marrow1.10745583
81* MP0002066_abnormal_motor_capabilities/c1.10716848
82MP0000465_gastrointestinal_hemorrhage1.10267063
83MP0002009_preneoplasia1.10094419
84* MP0002152_abnormal_brain_morphology1.09079094
85MP0003631_nervous_system_phenotype1.08513433
86MP0000759_abnormal_skeletal_muscle1.07607546
87MP0002269_muscular_atrophy1.00119521
88MP0003866_abnormal_defecation0.99690252
89MP0001545_abnormal_hematopoietic_system0.99677875
90MP0005397_hematopoietic_system_phenotyp0.99677875
91MP0009115_abnormal_fat_cell0.96948771
92MP0005620_abnormal_muscle_contractility0.95559309
93MP0004145_abnormal_muscle_electrophysio0.94490802
94MP0005174_abnormal_tail_pigmentation0.94391513
95MP0005409_darkened_coat_color0.93820197
96MP0006072_abnormal_retinal_apoptosis0.93401549
97MP0002127_abnormal_cardiovascular_syste0.93374800
98MP0000631_abnormal_neuroendocrine_gland0.92935237
99MP0002971_abnormal_brown_adipose0.92706554
100MP0001851_eye_inflammation0.92395604
101MP0004215_abnormal_myocardial_fiber0.92247603
102MP0004742_abnormal_vestibular_system0.91840223
103* MP0002229_neurodegeneration0.91615240
104MP0001299_abnormal_eye_distance/0.91378957
105MP0002420_abnormal_adaptive_immunity0.91348181
106MP0004510_myositis0.91189469
107MP0003172_abnormal_lysosome_physiology0.91135753
108MP0004085_abnormal_heartbeat0.91097075
109MP0010630_abnormal_cardiac_muscle0.90877540
110MP0004885_abnormal_endolymph0.90681632
111MP0001819_abnormal_immune_cell0.87910694
112MP0005369_muscle_phenotype0.86583862
113MP0000751_myopathy0.85523098
114MP0004883_abnormal_blood_vessel0.85330614
115MP0000689_abnormal_spleen_morphology0.84911558
116MP0005499_abnormal_olfactory_system0.84628269
117MP0005394_taste/olfaction_phenotype0.84628269
118MP0000013_abnormal_adipose_tissue0.84317255
119MP0004147_increased_porphyrin_level0.83133750
120MP0000716_abnormal_immune_system0.83006186
121MP0005253_abnormal_eye_physiology0.82935767
122MP0002722_abnormal_immune_system0.82481519
123MP0000685_abnormal_immune_system0.82437377
124MP0002006_tumorigenesis0.81869723
125MP0005464_abnormal_platelet_physiology0.79813596
126MP0001177_atelectasis0.79682208
127MP0002723_abnormal_immune_serum0.79581901
128MP0006138_congestive_heart_failure0.79191239
129MP0003632_abnormal_nervous_system0.78812141
130MP0005076_abnormal_cell_differentiation0.78596614
131MP0005266_abnormal_metabolism0.78436962
132MP0008995_early_reproductive_senescence0.76977871
133MP0000747_muscle_weakness0.75935395
134MP0003329_amyloid_beta_deposits0.75727686
135MP0002452_abnormal_antigen_presenting0.75243564
136MP0003868_abnormal_feces_composition0.73861987
137MP0003890_abnormal_embryonic-extraembry0.70932959
138MP0005167_abnormal_blood-brain_barrier0.70902698
139MP0002419_abnormal_innate_immunity0.70826677
140MP0002069_abnormal_eating/drinking_beha0.70256887
141MP0002168_other_aberrant_phenotype0.70012218
142MP0008872_abnormal_physiological_respon0.68273927
143MP0003861_abnormal_nervous_system0.67828005
144MP0004233_abnormal_muscle_weight0.67586554
145MP0010386_abnormal_urinary_bladder0.67484629
146MP0002638_abnormal_pupillary_reflex0.67284571
147MP0003300_gastrointestinal_ulcer0.64982448
148MP0002090_abnormal_vision0.64943938
149MP0005187_abnormal_penis_morphology0.64561994
150MP0004484_altered_response_of0.63798880
151MP0001943_abnormal_respiration0.62085357
152MP0005535_abnormal_body_temperature0.61924145
153MP0002082_postnatal_lethality0.61838689
154MP0010770_preweaning_lethality0.61838689
155MP0005171_absent_coat_pigmentation0.61163015
156MP0003698_abnormal_male_reproductive0.60232286
157MP0002752_abnormal_somatic_nervous0.60059767
158* MP0010769_abnormal_survival0.60022363
159MP0008874_decreased_physiological_sensi0.59557142
160MP0001963_abnormal_hearing_physiology0.58618006
161* MP0010768_mortality/aging0.57578805
162MP0003634_abnormal_glial_cell0.56014529
163MP0002095_abnormal_skin_pigmentation0.55986158

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.94983128
2Focal motor seizures (HP:0011153)4.88562042
3Focal seizures (HP:0007359)4.69145589
4Epileptic encephalopathy (HP:0200134)4.13917618
5Difficulty running (HP:0009046)3.80558738
6Progressive cerebellar ataxia (HP:0002073)3.76237321
7Atonic seizures (HP:0010819)3.44872351
8Macroorchidism (HP:0000053)3.26168925
9Gaze-evoked nystagmus (HP:0000640)3.23554898
10Visual hallucinations (HP:0002367)3.23057437
11Genetic anticipation (HP:0003743)3.06183967
12Absence seizures (HP:0002121)3.04697978
13Drooling (HP:0002307)3.02280654
14Excessive salivation (HP:0003781)3.02280654
15Myokymia (HP:0002411)2.99776192
16T lymphocytopenia (HP:0005403)2.99436027
17Action tremor (HP:0002345)2.97280840
18Truncal ataxia (HP:0002078)2.95571019
19Urinary bladder sphincter dysfunction (HP:0002839)2.94270159
20Impaired smooth pursuit (HP:0007772)2.93533762
21Broad-based gait (HP:0002136)2.91782205
22Volvulus (HP:0002580)2.89968176
23Generalized tonic-clonic seizures (HP:0002069)2.86425101
24Hyporeflexia of lower limbs (HP:0002600)2.85421039
25Muscle fiber inclusion bodies (HP:0100299)2.84492914
26Exercise-induced myalgia (HP:0003738)2.82418119
27Hyperkalemia (HP:0002153)2.79429246
28Abnormality of the fingertips (HP:0001211)2.77365863
29Protruding tongue (HP:0010808)2.75252746
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75167070
31Subaortic stenosis (HP:0001682)2.73198378
32Abnormality of the left ventricular outflow tract (HP:0011103)2.73198378
33Spontaneous hematomas (HP:0007420)2.72355738
34Hemiparesis (HP:0001269)2.71921985
35Abnormality of ocular smooth pursuit (HP:0000617)2.71718062
36Dialeptic seizures (HP:0011146)2.71595978
37Dysmetric saccades (HP:0000641)2.66830266
38Nemaline bodies (HP:0003798)2.66512148
39Heterotopia (HP:0002282)2.62522984
40Abnormality of T cell number (HP:0011839)2.62076093
41Impaired vibration sensation in the lower limbs (HP:0002166)2.58654836
42Abnormality of the lower motor neuron (HP:0002366)2.53908373
43Dysdiadochokinesis (HP:0002075)2.49521376
44Absent speech (HP:0001344)2.48760016
45Poor eye contact (HP:0000817)2.48660906
46Hyperventilation (HP:0002883)2.45244080
47Subacute progressive viral hepatitis (HP:0006572)2.44453155
48Depression (HP:0000716)2.43520486
49Impaired social interactions (HP:0000735)2.42905016
50Abnormal social behavior (HP:0012433)2.42905016
51Postural instability (HP:0002172)2.40781524
52Eczematoid dermatitis (HP:0000976)2.40084469
53Colitis (HP:0002583)2.37177153
54Aqueductal stenosis (HP:0002410)2.35021007
55Lower limb amyotrophy (HP:0007210)2.33403025
56Urinary urgency (HP:0000012)2.31928499
57Frequent falls (HP:0002359)2.31377474
58Obsessive-compulsive behavior (HP:0000722)2.30856231
59Truncal obesity (HP:0001956)2.25184650
60Abnormal hair whorl (HP:0010721)2.23068315
61Hemiplegia (HP:0002301)2.21190747
62Absent frontal sinuses (HP:0002688)2.20082075
63Scanning speech (HP:0002168)2.18941188
64Inappropriate behavior (HP:0000719)2.18305867
65Calf muscle hypertrophy (HP:0008981)2.17850257
66Blue irides (HP:0000635)2.17118268
67Supranuclear gaze palsy (HP:0000605)2.16374314
68Epileptiform EEG discharges (HP:0011182)2.16108548
69EMG: neuropathic changes (HP:0003445)2.15956459
70Recurrent bacterial skin infections (HP:0005406)2.14997504
71Muscle hypertrophy of the lower extremities (HP:0008968)2.13861091
72Neonatal hypoglycemia (HP:0001998)2.12268845
73Slow saccadic eye movements (HP:0000514)2.12077465
74Insidious onset (HP:0003587)2.11845135
75Termporal pattern (HP:0011008)2.11845135
76Narrow palate (HP:0000189)2.10330853
77Open mouth (HP:0000194)2.09764093
78EEG with generalized epileptiform discharges (HP:0011198)2.09339277
79Insomnia (HP:0100785)2.07921425
80Papillary thyroid carcinoma (HP:0002895)2.05012591
81Muscle fiber splitting (HP:0003555)2.03015283
82Abnormality of binocular vision (HP:0011514)2.02691979
83Diplopia (HP:0000651)2.02691979
84Thyroid carcinoma (HP:0002890)2.01946552
85Type 1 muscle fiber predominance (HP:0003803)2.00815561
86Abnormality of salivation (HP:0100755)2.00078516
87Overgrowth (HP:0001548)1.98558131
88Short chin (HP:0000331)1.98080390
89Ankle clonus (HP:0011448)1.97768971
90Pointed chin (HP:0000307)1.97740011
91Impaired vibratory sensation (HP:0002495)1.97094569
92Dysmetria (HP:0001310)1.96940584
93Gingivitis (HP:0000230)1.96107682
94Widely spaced teeth (HP:0000687)1.95279616
95Hypsarrhythmia (HP:0002521)1.93670163
96Papilledema (HP:0001085)1.92892871
97Bradykinesia (HP:0002067)1.91186325
98Sandal gap (HP:0001852)1.90987990
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.89974406
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89974406
101Exotropia (HP:0000577)1.89842643
102Stereotypic behavior (HP:0000733)1.88545585
103Acute myeloid leukemia (HP:0004808)1.88515382
104Viral hepatitis (HP:0006562)1.87892932
105Generalized hypopigmentation of hair (HP:0011358)1.87674526
106Abnormality of the corticospinal tract (HP:0002492)1.87035462
107Prominent nose (HP:0000448)1.86667951
108Germ cell neoplasia (HP:0100728)1.86240613
109Recurrent fungal infections (HP:0002841)1.84515448
110Distal arthrogryposis (HP:0005684)1.84512674
111Central scotoma (HP:0000603)1.84444717
112Elfin facies (HP:0004428)1.84134743
113Hematochezia (HP:0002573)1.83267579
114Amblyopia (HP:0000646)1.83239793
115Sudden death (HP:0001699)1.82332835
116Spastic gait (HP:0002064)1.79722948
117Chest pain (HP:0100749)1.78021925
118Gastrointestinal infarctions (HP:0005244)1.77505349
119Lower limb muscle weakness (HP:0007340)1.76755757
120Congenital stationary night blindness (HP:0007642)1.75507414
121EMG: myopathic abnormalities (HP:0003458)1.75454480
122Conjunctival telangiectasia (HP:0000524)1.75254553
123Deeply set eye (HP:0000490)1.72818856
124Thyroiditis (HP:0100646)1.72118369
125Long clavicles (HP:0000890)1.70893472
126Agitation (HP:0000713)1.69986287
127Anxiety (HP:0000739)1.69937201
128Status epilepticus (HP:0002133)1.69060476
129Submucous cleft hard palate (HP:0000176)1.68862047
130Recurrent abscess formation (HP:0002722)1.67867851
131Autism (HP:0000717)1.67582013
132Hyperacusis (HP:0010780)1.67419383
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.67300035
134Resting tremor (HP:0002322)1.67016403
135Dislocated radial head (HP:0003083)1.64616485
136Inflammation of the large intestine (HP:0002037)1.64026940
137Gingival bleeding (HP:0000225)1.63624634
138Abnormality of the nasal septum (HP:0000419)1.63507982
139Abnormality of the ischium (HP:0003174)1.63286557
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63000527
141Prolonged bleeding time (HP:0003010)1.61734600
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.61709804
143Neoplasm of the heart (HP:0100544)1.61040201
144Poikilocytosis (HP:0004447)1.60446452
145Progressive inability to walk (HP:0002505)1.60162392
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59994482
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59795312
148Tented upper lip vermilion (HP:0010804)1.59348475
149Abnormality of the astrocytes (HP:0100707)1.56294773
150Astrocytoma (HP:0009592)1.56294773
151Fair hair (HP:0002286)1.56187889
152Intention tremor (HP:0002080)1.53654441
153Mask-like facies (HP:0000298)1.53275958
154Hypochromic microcytic anemia (HP:0004840)1.52972333
155Tapered finger (HP:0001182)1.52219104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.97310976
2MAP3K43.32482871
3EPHA42.84796645
4OBSCN2.77074477
5MARK12.63349105
6MAP3K92.61337625
7CAMK1G2.50080624
8MAP2K72.34703325
9SIK22.29203716
10SGK22.24154179
11DAPK22.02170691
12RIPK41.99546109
13SGK31.88930566
14BRD41.88619627
15CAMK1D1.86370110
16MINK11.82894749
17NTRK21.82513422
18BLK1.76345809
19CASK1.68165892
20PIK3CG1.67331276
21PNCK1.63076507
22CDK121.60628758
23SGK2231.57350858
24SGK4941.57350858
25MAPK131.53389847
26MAP2K41.52585184
27NLK1.47238025
28TRPM71.42735589
29TTN1.41402971
30PAK61.40599982
31INSRR1.37904030
32EPHA31.36361453
33TNIK1.35855563
34CAMKK11.31111065
35MAP3K131.28155214
36KSR11.27894660
37CDK51.26347814
38MAP3K101.26325295
39SGK11.25165182
40PRKD31.24704276
41PRPF4B1.23050394
42MAPK121.21190651
43SYK1.21040824
44EEF2K1.15041460
45STK381.14042348
46MAP4K11.13200774
47BTK1.12263139
48MAP2K31.10785301
49WNK11.08236433
50FES1.06261346
51TEC1.05958738
52RET1.03577295
53PRKCH1.01550101
54NTRK11.00996742
55PLK21.00770712
56RIPK11.00439137
57CDC42BPA0.98179185
58HCK0.95213223
59ITK0.95139749
60IKBKE0.94820697
61JAK20.93778974
62CAMKK20.93184181
63DAPK10.91828710
64FGFR30.91287764
65MAP3K20.88191942
66DYRK1A0.88077872
67STK110.88073435
68FRK0.86504014
69MAP3K70.85894815
70PINK10.84035518
71YES10.83293823
72MARK30.82516798
73KSR20.81946869
74AKT30.80324571
75CDK90.79883266
76MARK20.79324204
77JAK30.78962466
78CSK0.78958385
79PRKAA20.78853638
80CAMK40.77833735
81NEK60.77016517
82FGFR20.76528486
83CAMK10.75928741
84FGR0.73264980
85GRK60.72030103
86ZAP700.71464327
87PTK2B0.70490991
88PHKG10.70354152
89PHKG20.70354152
90MAPK70.69226737
91RPS6KA20.69208900
92MAPK100.68818433
93RPS6KA30.68686164
94ERBB30.68588238
95DMPK0.67492343
96SCYL20.66856713
97LMTK20.65492006
98PRKCG0.64193563
99PDK10.63788252
100FGFR40.63674243
101LCK0.62871991
102RAF10.62253287
103TYK20.62076903
104TXK0.61847888
105TNK20.61128786
106JAK10.60395941
107PIK3CA0.59853340
108GRK50.59551348
109PIM10.59266870
110CCNB10.58981988
111MAP3K10.58838189
112CAMK2A0.57879702
113MAP3K140.57823286
114TAOK30.57173003
115PRKAA10.56862657
116TYRO30.55019688
117UHMK10.54171930
118MAPK80.53842665
119RPS6KB10.52973215
120PDGFRB0.52711700
121STK40.52288743
122ALK0.52124797
123MTOR0.52108944
124GSK3B0.51861837
125HIPK20.51179551
126CDK30.50938290
127MAPK110.50136684
128PKN20.49434938
129PRKDC0.48428910
130PRKCB0.48018653
131MAP3K60.46842436
132MAPK140.42332958
133CSNK1G20.42235182
134FYN0.41573094
135PDGFRA0.39033246
136ATM0.38446115
137BMPR20.38102401
138PRKG10.36871531
139TAOK10.36757525
140NUAK10.36538334
141PKN10.36521020
142CSNK1D0.36043137
143PDPK10.35826481
144PAK30.35795890

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97706675
2Circadian entrainment_Homo sapiens_hsa047132.31776014
3Olfactory transduction_Homo sapiens_hsa047402.29965464
4Synaptic vesicle cycle_Homo sapiens_hsa047212.29722924
5Long-term potentiation_Homo sapiens_hsa047202.26623145
6Morphine addiction_Homo sapiens_hsa050322.19760937
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19375104
8Glutamatergic synapse_Homo sapiens_hsa047242.09090519
9GABAergic synapse_Homo sapiens_hsa047272.07364465
10Salivary secretion_Homo sapiens_hsa049701.93800190
11Amphetamine addiction_Homo sapiens_hsa050311.90756219
12Insulin secretion_Homo sapiens_hsa049111.88170912
13Dopaminergic synapse_Homo sapiens_hsa047281.81616130
14Type II diabetes mellitus_Homo sapiens_hsa049301.76850508
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69418696
16Renin secretion_Homo sapiens_hsa049241.69262349
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67844669
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.67001182
19Cholinergic synapse_Homo sapiens_hsa047251.65100672
20Taste transduction_Homo sapiens_hsa047421.61685467
21Gastric acid secretion_Homo sapiens_hsa049711.54878693
22Oxytocin signaling pathway_Homo sapiens_hsa049211.53853974
23Long-term depression_Homo sapiens_hsa047301.50771551
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49727169
25Calcium signaling pathway_Homo sapiens_hsa040201.43547195
26Acute myeloid leukemia_Homo sapiens_hsa052211.43437314
27Dorso-ventral axis formation_Homo sapiens_hsa043201.39417399
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35828114
29Serotonergic synapse_Homo sapiens_hsa047261.34449241
30GnRH signaling pathway_Homo sapiens_hsa049121.33277698
31cAMP signaling pathway_Homo sapiens_hsa040241.28478241
32Cocaine addiction_Homo sapiens_hsa050301.26875490
33Osteoclast differentiation_Homo sapiens_hsa043801.26358027
34Glioma_Homo sapiens_hsa052141.24509843
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23313057
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21728433
37Gap junction_Homo sapiens_hsa045401.20040796
38Estrogen signaling pathway_Homo sapiens_hsa049151.17137087
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16733496
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13385536
41ErbB signaling pathway_Homo sapiens_hsa040121.09307212
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04769709
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.03116503
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02178179
45Inositol phosphate metabolism_Homo sapiens_hsa005621.00539401
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99402720
47mTOR signaling pathway_Homo sapiens_hsa041500.98804942
48Phototransduction_Homo sapiens_hsa047440.98623266
49Axon guidance_Homo sapiens_hsa043600.97811870
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96308746
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.93858296
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.93089226
53Leishmaniasis_Homo sapiens_hsa051400.92500983
54Choline metabolism in cancer_Homo sapiens_hsa052310.92398071
55Alcoholism_Homo sapiens_hsa050340.91907643
56Dilated cardiomyopathy_Homo sapiens_hsa054140.90695928
57Melanogenesis_Homo sapiens_hsa049160.90185456
58Endometrial cancer_Homo sapiens_hsa052130.87535742
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.87324453
60Prostate cancer_Homo sapiens_hsa052150.86579587
61MAPK signaling pathway_Homo sapiens_hsa040100.86440145
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.86384844
63Circadian rhythm_Homo sapiens_hsa047100.84966313
64Pancreatic secretion_Homo sapiens_hsa049720.84712949
65Oocyte meiosis_Homo sapiens_hsa041140.83760872
66Measles_Homo sapiens_hsa051620.81922903
67Glucagon signaling pathway_Homo sapiens_hsa049220.79785592
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78960158
69Hepatitis B_Homo sapiens_hsa051610.78401540
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78290517
71Non-small cell lung cancer_Homo sapiens_hsa052230.78084706
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77215449
73Toxoplasmosis_Homo sapiens_hsa051450.76255843
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.76110678
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75355350
76Collecting duct acid secretion_Homo sapiens_hsa049660.75134842
77Tuberculosis_Homo sapiens_hsa051520.75118732
78HIF-1 signaling pathway_Homo sapiens_hsa040660.74315068
79Thyroid hormone synthesis_Homo sapiens_hsa049180.74157621
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.73665903
81ABC transporters_Homo sapiens_hsa020100.73131363
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70433680
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70319632
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69962888
85Insulin signaling pathway_Homo sapiens_hsa049100.69247837
86Adherens junction_Homo sapiens_hsa045200.68888541
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67513232
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66725595
89Focal adhesion_Homo sapiens_hsa045100.64054162
90MicroRNAs in cancer_Homo sapiens_hsa052060.63325511
91TNF signaling pathway_Homo sapiens_hsa046680.62905049
92Chemokine signaling pathway_Homo sapiens_hsa040620.61597967
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60933444
94Rap1 signaling pathway_Homo sapiens_hsa040150.60673474
95Colorectal cancer_Homo sapiens_hsa052100.60556138
96Influenza A_Homo sapiens_hsa051640.60285294
97Hepatitis C_Homo sapiens_hsa051600.60107000
98Lysine degradation_Homo sapiens_hsa003100.59389385
99Prolactin signaling pathway_Homo sapiens_hsa049170.59303699
100VEGF signaling pathway_Homo sapiens_hsa043700.59230401
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59134855
102T cell receptor signaling pathway_Homo sapiens_hsa046600.58993543
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58257070
104Platelet activation_Homo sapiens_hsa046110.58241961
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57854827
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57142415
107FoxO signaling pathway_Homo sapiens_hsa040680.56922097
108Ras signaling pathway_Homo sapiens_hsa040140.56344087
109Wnt signaling pathway_Homo sapiens_hsa043100.54702555
110B cell receptor signaling pathway_Homo sapiens_hsa046620.53731273
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51271878
112Renal cell carcinoma_Homo sapiens_hsa052110.50734175
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.50685779
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49471439
115Insulin resistance_Homo sapiens_hsa049310.47765936
116Chronic myeloid leukemia_Homo sapiens_hsa052200.47705902
117AMPK signaling pathway_Homo sapiens_hsa041520.47165902
118Pancreatic cancer_Homo sapiens_hsa052120.47056321
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46526342
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45628047
121Endocytosis_Homo sapiens_hsa041440.45052232
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43393615
123Ovarian steroidogenesis_Homo sapiens_hsa049130.42467286
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.41420536
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39396740

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