HERC2P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)6.52283986
2sperm motility (GO:0030317)6.01132974
3DNA packaging (GO:0006323)5.14852972
4acrosome reaction (GO:0007340)5.02864088
5chromosome condensation (GO:0030261)5.00887736
6centriole assembly (GO:0098534)4.89050497
7microtubule depolymerization (GO:0007019)4.76970822
8mast cell activation involved in immune response (GO:0002279)4.73767324
9mast cell degranulation (GO:0043303)4.73767324
10single strand break repair (GO:0000012)4.46342897
11centrosome duplication (GO:0051298)4.30548907
12spermatid development (GO:0007286)4.26966885
13microtubule polymerization or depolymerization (GO:0031109)4.09207426
14purine deoxyribonucleotide catabolic process (GO:0009155)4.05340638
15fusion of sperm to egg plasma membrane (GO:0007342)3.92841857
16neutrophil mediated immunity (GO:0002446)3.90512107
17modulation of growth of symbiont involved in interaction with host (GO:0044144)3.87109629
18regulation of growth of symbiont in host (GO:0044126)3.87109629
19negative regulation of growth of symbiont in host (GO:0044130)3.87109629
20negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.87109629
21nuclear pore complex assembly (GO:0051292)3.84382121
22response to pheromone (GO:0019236)3.83794693
23regulation of centriole replication (GO:0046599)3.83313550
24seminiferous tubule development (GO:0072520)3.82638886
25positive regulation of granulocyte differentiation (GO:0030854)3.74898182
26regulation of histone H3-K9 methylation (GO:0051570)3.67007573
27sperm-egg recognition (GO:0035036)3.64253405
28melanin metabolic process (GO:0006582)3.62255639
29spermatid nucleus differentiation (GO:0007289)3.57939413
30definitive hemopoiesis (GO:0060216)3.53508952
31melanin biosynthetic process (GO:0042438)3.51442909
32sperm capacitation (GO:0048240)3.50440021
33protein polyglutamylation (GO:0018095)3.42010022
34establishment of protein localization to Golgi (GO:0072600)3.37383602
35nuclear pore organization (GO:0006999)3.37016700
36pore complex assembly (GO:0046931)3.35459489
37regulation of cilium movement (GO:0003352)3.30016244
38negative regulation of histone methylation (GO:0031061)3.29675820
39cellular extravasation (GO:0045123)3.29336354
40binding of sperm to zona pellucida (GO:0007339)3.24312147
41microtubule nucleation (GO:0007020)3.21706796
42mast cell activation (GO:0045576)3.21128017
43protein targeting to Golgi (GO:0000042)3.18379565
44multicellular organism reproduction (GO:0032504)3.14909179
45cilium or flagellum-dependent cell motility (GO:0001539)3.13944653
46cell-cell recognition (GO:0009988)3.12702685
47microtubule severing (GO:0051013)3.09090203
48myeloid leukocyte mediated immunity (GO:0002444)3.08912203
49DNA conformation change (GO:0071103)3.08308024
50peptidyl-lysine trimethylation (GO:0018023)2.98336663
51positive regulation of Rab GTPase activity (GO:0032851)2.97557432
52regulation of Rab GTPase activity (GO:0032313)2.97557432
53histone H3-K4 trimethylation (GO:0080182)2.96267510
54histone H3-K9 methylation (GO:0051567)2.95653826
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95623203
56response to hydroperoxide (GO:0033194)2.95290784
57plasma membrane fusion (GO:0045026)2.92668457
58cell wall macromolecule metabolic process (GO:0044036)2.88221461
59rRNA methylation (GO:0031167)2.87275339
60cell wall macromolecule catabolic process (GO:0016998)2.86702467
61disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.86234401
62killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.86234401
63mature B cell differentiation involved in immune response (GO:0002313)2.85270568
64histone mRNA catabolic process (GO:0071044)2.83973378
65positive regulation of B cell differentiation (GO:0045579)2.83641146
66regulation of MHC class II biosynthetic process (GO:0045346)2.81477241
67male gamete generation (GO:0048232)2.81307348
68spermatogenesis (GO:0007283)2.81194989
69defense response to protozoan (GO:0042832)2.79309779
70regulation of granulocyte differentiation (GO:0030852)2.79098263
71male meiosis I (GO:0007141)2.78050624
72centrosome organization (GO:0051297)2.77719019
73reproduction (GO:0000003)2.77303897
74histone exchange (GO:0043486)2.76858225
75chromatin silencing (GO:0006342)2.76080011
76lysosome localization (GO:0032418)2.75012161
77leukocyte degranulation (GO:0043299)2.74573488
78double-strand break repair via homologous recombination (GO:0000724)2.74214618
79negative regulation of histone modification (GO:0031057)2.73308429
80regulation of chemokine biosynthetic process (GO:0045073)2.70373422
81cardiolipin metabolic process (GO:0032048)2.70119569
82recombinational repair (GO:0000725)2.69757769
83secondary metabolite biosynthetic process (GO:0044550)2.69515088
84response to protozoan (GO:0001562)2.69123380
85piRNA metabolic process (GO:0034587)2.69049786
86negative regulation of interleukin-17 production (GO:0032700)2.68412949
87phosphatidylethanolamine biosynthetic process (GO:0006646)2.66150196
88ketone body metabolic process (GO:1902224)2.65515564
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64758555
90positive regulation of protein import into nucleus, translocation (GO:0033160)2.64565810
91inflammatory response to antigenic stimulus (GO:0002437)2.64101749
92rRNA modification (GO:0000154)2.62622403
93negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.62091998
94telomere maintenance via semi-conservative replication (GO:0032201)2.59427165
95gamete generation (GO:0007276)2.59047024
96negative regulation of DNA repair (GO:0045738)2.56944337
97microtubule organizing center organization (GO:0031023)2.56914006
98purine deoxyribonucleotide metabolic process (GO:0009151)2.55804808
99histone H3-K9 modification (GO:0061647)2.55588790
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55418952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85651949
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.46061588
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.01005670
4SCL_19346495_ChIP-Seq_HPC-7_Human2.68541215
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65541425
6GATA1_22025678_ChIP-Seq_K562_Human2.48161560
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.46988199
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31123509
9MYB_26560356_Chip-Seq_TH2_Human2.18627723
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17624557
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.00825741
12VDR_21846776_ChIP-Seq_THP-1_Human1.93149335
13ZNF274_21170338_ChIP-Seq_K562_Hela1.91697515
14MYB_26560356_Chip-Seq_TH1_Human1.78076795
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69189942
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67752794
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65405473
18VDR_23849224_ChIP-Seq_CD4+_Human1.64043079
19VDR_24763502_ChIP-Seq_THP-1_Human1.62297611
20SPI1_23547873_ChIP-Seq_NB4_Human1.60874980
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60159653
22RUNX_20019798_ChIP-Seq_JUKART_Human1.56495833
23KDM5A_27292631_Chip-Seq_BREAST_Human1.56388597
24CIITA_25753668_ChIP-Seq_RAJI_Human1.54590588
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.53169636
26MYC_22102868_ChIP-Seq_BL_Human1.50488737
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49644867
28FOXP3_21729870_ChIP-Seq_TREG_Human1.44542632
29FUS_26573619_Chip-Seq_HEK293_Human1.40503604
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.40105766
31GATA3_26560356_Chip-Seq_TH2_Human1.37794750
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36517642
33CBP_20019798_ChIP-Seq_JUKART_Human1.36517642
34ER_23166858_ChIP-Seq_MCF-7_Human1.35426815
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33621732
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32921743
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32511367
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32210501
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30494392
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29739491
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29288513
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28360288
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.26076596
44TAF15_26573619_Chip-Seq_HEK293_Human1.25890904
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.22946730
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22531249
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20108753
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20063907
49GATA3_27048872_Chip-Seq_THYMUS_Human1.17687925
50VDR_24787735_ChIP-Seq_THP-1_Human1.15623663
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15430542
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.13582178
53P300_27268052_Chip-Seq_Bcells_Human1.12690564
54TFEB_21752829_ChIP-Seq_HELA_Human1.12409634
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11141975
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.10509323
57UTX_26944678_Chip-Seq_JUKART_Human1.09731102
58SPI1_23127762_ChIP-Seq_K562_Human1.09685280
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08398707
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07624927
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05904576
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05452517
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04673773
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03759552
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03759552
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02741249
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.00898337
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00720956
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98934250
70BCL6_27268052_Chip-Seq_Bcells_Human0.98640409
71THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97769332
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97350155
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96911675
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96605022
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96332089
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95779583
77ERA_21632823_ChIP-Seq_H3396_Human0.95692151
78IGF1R_20145208_ChIP-Seq_DFB_Human0.95564670
79SALL4_22934838_ChIP-ChIP_CD34+_Human0.95356232
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93590503
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92889381
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91380462
83BCOR_27268052_Chip-Seq_Bcells_Human0.91304873
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.90821626
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90297731
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90256150
87ELK1_19687146_ChIP-ChIP_HELA_Human0.90089454
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89894111
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89502269
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89205885
91GABP_19822575_ChIP-Seq_HepG2_Human0.88904140
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88878777
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88526701
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88130936
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87741403
96VDR_22108803_ChIP-Seq_LS180_Human0.87150686
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86337581
98NFYB_21822215_ChIP-Seq_K562_Human0.86134993
99MAF_26560356_Chip-Seq_TH1_Human0.86005938
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85220507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.05895479
2MP0005410_abnormal_fertilization4.23734869
3MP0000569_abnormal_digit_pigmentation3.99099095
4MP0000015_abnormal_ear_pigmentation3.29992941
5MP0008057_abnormal_DNA_replication3.21242475
6MP0005174_abnormal_tail_pigmentation3.19256899
7MP0005171_absent_coat_pigmentation2.66705479
8MP0005408_hypopigmentation2.49864623
9MP0005670_abnormal_white_adipose2.49318410
10MP0005075_abnormal_melanosome_morpholog2.45850589
11MP0002396_abnormal_hematopoietic_system2.42402844
12MP0002095_abnormal_skin_pigmentation2.40432121
13MP0003718_maternal_effect2.38956105
14MP0009278_abnormal_bone_marrow2.30679316
15MP0010094_abnormal_chromosome_stability2.30346187
16MP0005397_hematopoietic_system_phenotyp2.24947755
17MP0001545_abnormal_hematopoietic_system2.24947755
18MP0008058_abnormal_DNA_repair2.15182191
19MP0001348_abnormal_lacrimal_gland2.14684182
20MP0000371_diluted_coat_color1.97596068
21MP0001835_abnormal_antigen_presentation1.92537755
22MP0003698_abnormal_male_reproductive1.86786420
23MP0002822_catalepsy1.85867681
24MP0001929_abnormal_gametogenesis1.84091428
25MP0003077_abnormal_cell_cycle1.74273270
26MP0003136_yellow_coat_color1.65513739
27MP0004381_abnormal_hair_follicle1.53504450
28MP0003436_decreased_susceptibility_to1.46848384
29MP0005464_abnormal_platelet_physiology1.42802154
30MP0005645_abnormal_hypothalamus_physiol1.41580280
31MP0002419_abnormal_innate_immunity1.39801041
32MP0003172_abnormal_lysosome_physiology1.36301587
33MP0005377_hearing/vestibular/ear_phenot1.35210556
34MP0003878_abnormal_ear_physiology1.35210556
35MP0002877_abnormal_melanocyte_morpholog1.32386394
36MP0005671_abnormal_response_to1.31161448
37MP0003252_abnormal_bile_duct1.29660099
38MP0003111_abnormal_nucleus_morphology1.29184842
39MP0005000_abnormal_immune_tolerance1.26610747
40MP0005310_abnormal_salivary_gland1.26559139
41MP0004808_abnormal_hematopoietic_stem1.26527836
42MP0003763_abnormal_thymus_physiology1.22745230
43MP0002398_abnormal_bone_marrow1.21909733
44MP0000685_abnormal_immune_system1.21138444
45MP0001800_abnormal_humoral_immune1.19975824
46MP0002452_abnormal_antigen_presenting1.19551452
47MP0002420_abnormal_adaptive_immunity1.12781822
48MP0002723_abnormal_immune_serum1.11722728
49MP0000689_abnormal_spleen_morphology1.11257865
50MP0005025_abnormal_response_to1.11182952
51MP0001819_abnormal_immune_cell1.10841081
52MP0008007_abnormal_cellular_replicative1.06512411
53MP0002161_abnormal_fertility/fecundity1.05270884
54MP0002722_abnormal_immune_system1.05259550
55MP0002148_abnormal_hypersensitivity_rea1.05042419
56MP0003786_premature_aging1.03931774
57MP0009697_abnormal_copulation1.03460456
58MP0002075_abnormal_coat/hair_pigmentati1.01821946
59MP0001790_abnormal_immune_system1.01125974
60MP0005387_immune_system_phenotype1.01125974
61MP0009765_abnormal_xenobiotic_induced1.00604729
62MP0009785_altered_susceptibility_to0.99956969
63MP0000716_abnormal_immune_system0.98509462
64MP0001986_abnormal_taste_sensitivity0.94765869
65MP0002638_abnormal_pupillary_reflex0.94245219
66MP0004957_abnormal_blastocyst_morpholog0.93836469
67MP0003806_abnormal_nucleotide_metabolis0.91777870
68MP0003656_abnormal_erythrocyte_physiolo0.91549531
69MP0002429_abnormal_blood_cell0.91459793
70MP0002405_respiratory_system_inflammati0.89615725
71MP0000465_gastrointestinal_hemorrhage0.88088675
72MP0002210_abnormal_sex_determination0.87938304
73MP0008260_abnormal_autophagy0.87430266
74MP0009764_decreased_sensitivity_to0.87040427
75MP0002019_abnormal_tumor_incidence0.84640274
76MP0000703_abnormal_thymus_morphology0.84412189
77MP0002938_white_spotting0.84342064
78MP0000653_abnormal_sex_gland0.82658485
79MP0005253_abnormal_eye_physiology0.81194977
80MP0001145_abnormal_male_reproductive0.80727402
81MP0005395_other_phenotype0.78491329
82MP0001501_abnormal_sleep_pattern0.77453053
83MP0009115_abnormal_fat_cell0.76924224
84MP0005266_abnormal_metabolism0.76778900
85MP0001873_stomach_inflammation0.76618035
86MP0002009_preneoplasia0.73815930
87MP0008877_abnormal_DNA_methylation0.72563529
88MP0002166_altered_tumor_susceptibility0.72208596
89MP0008995_early_reproductive_senescence0.70845313
90MP0001851_eye_inflammation0.69887324
91MP0001764_abnormal_homeostasis0.69693462
92MP0001186_pigmentation_phenotype0.68926946
93MP0002229_neurodegeneration0.68477008
94MP0001486_abnormal_startle_reflex0.66707148
95MP0001853_heart_inflammation0.66506385
96MP0004147_increased_porphyrin_level0.64763750
97MP0003787_abnormal_imprinting0.64420526
98MP0006036_abnormal_mitochondrial_physio0.63035512
99MP0003186_abnormal_redox_activity0.62196213
100MP0010307_abnormal_tumor_latency0.61584115

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.51918174
2Abnormality of the prostate (HP:0008775)3.87921856
3Thrombocytosis (HP:0001894)3.48646976
4Recurrent cutaneous fungal infections (HP:0011370)3.28433221
5Chronic mucocutaneous candidiasis (HP:0002728)3.28433221
6Aplasia/Hypoplasia of the macula (HP:0008059)3.24104095
7Acute myeloid leukemia (HP:0004808)3.20767520
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.18879614
9Hypoplasia of the fovea (HP:0007750)3.18879614
10Albinism (HP:0001022)3.11854575
11Volvulus (HP:0002580)3.07885631
12Impulsivity (HP:0100710)3.00974274
13Myelodysplasia (HP:0002863)3.00720370
14Stomatitis (HP:0010280)2.94064412
15Aplasia/Hypoplasia affecting the retina (HP:0008061)2.92810196
16Prostate neoplasm (HP:0100787)2.91099765
17Congenital stationary night blindness (HP:0007642)2.89584564
18White forelock (HP:0002211)2.86602975
19Tubulointerstitial nephritis (HP:0001970)2.82588013
20Cone-rod dystrophy (HP:0000548)2.82151882
21Truncal obesity (HP:0001956)2.79959990
22Ocular albinism (HP:0001107)2.77057686
23Gaze-evoked nystagmus (HP:0000640)2.76843742
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75387684
25Genetic anticipation (HP:0003743)2.71815494
26Chromsome breakage (HP:0040012)2.69918458
27Attenuation of retinal blood vessels (HP:0007843)2.69227212
28Prolonged bleeding time (HP:0003010)2.61791630
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.61734266
30Progressive cerebellar ataxia (HP:0002073)2.61300408
31Abnormality of the fovea (HP:0000493)2.59437490
32Acute lymphatic leukemia (HP:0006721)2.58695527
33Patchy hypopigmentation of hair (HP:0011365)2.58120449
34Abnormality of T cell physiology (HP:0011840)2.52400689
35Fatigue (HP:0012378)2.47544389
36B lymphocytopenia (HP:0010976)2.46553437
37Aplasia/Hypoplasia of the earlobes (HP:0009906)2.44394992
38Agammaglobulinemia (HP:0004432)2.42900091
39Abnormality of chromosome stability (HP:0003220)2.39188711
40Recurrent fungal infections (HP:0002841)2.39147643
41Blue irides (HP:0000635)2.33883990
42Abnormality of male internal genitalia (HP:0000022)2.29495187
43Abnormality of DNA repair (HP:0003254)2.26944194
44Generalized hypopigmentation (HP:0007513)2.26747896
45Autoimmune thrombocytopenia (HP:0001973)2.24245119
46Abnormality of lateral ventricle (HP:0030047)2.23737897
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.23334783
48Abnormal auditory evoked potentials (HP:0006958)2.22658576
49Abnormality of B cell number (HP:0010975)2.22264341
50Absent/shortened dynein arms (HP:0200106)2.21133024
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.21133024
52Abnormality of macular pigmentation (HP:0008002)2.20252946
53Abnormality of the hepatic vasculature (HP:0006707)2.20122014
54Chest pain (HP:0100749)2.20046005
55Sloping forehead (HP:0000340)2.16451213
56Metaphyseal dysplasia (HP:0100255)2.16104693
57Abnormality of the preputium (HP:0100587)2.15675174
58Recurrent viral infections (HP:0004429)2.15571594
59Iris hypopigmentation (HP:0007730)2.13037979
60Granulocytopenia (HP:0001913)2.11586935
61Recurrent skin infections (HP:0001581)2.08819724
62Decreased central vision (HP:0007663)2.07400407
63Chronic hepatic failure (HP:0100626)2.00751916
64Obstructive lung disease (HP:0006536)2.00661855
65Chronic obstructive pulmonary disease (HP:0006510)2.00661855
66Spastic paraparesis (HP:0002313)1.98539531
67Autoimmune hemolytic anemia (HP:0001890)1.97570596
68Nephronophthisis (HP:0000090)1.97356327
69Upper limb muscle weakness (HP:0003484)1.96204102
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95870226
71Abnormality of the ileum (HP:0001549)1.93708031
72Elevated erythrocyte sedimentation rate (HP:0003565)1.92984643
73Duodenal stenosis (HP:0100867)1.90887696
74Small intestinal stenosis (HP:0012848)1.90887696
75Recurrent bacterial skin infections (HP:0005406)1.90403123
76Abnormal biliary tract physiology (HP:0012439)1.88912151
77Bile duct proliferation (HP:0001408)1.88912151
78Hypopigmentation of the fundus (HP:0007894)1.88712996
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88021470
80Clubbing of toes (HP:0100760)1.87041894
81Recurrent abscess formation (HP:0002722)1.86901600
82Panhypogammaglobulinemia (HP:0003139)1.86710768
83Meckel diverticulum (HP:0002245)1.86364935
84Birth length less than 3rd percentile (HP:0003561)1.85844794
85Hepatitis (HP:0012115)1.83833097
86Abnormality of the renal medulla (HP:0100957)1.83353800
87Abnormality of T cells (HP:0002843)1.82418953
88Portal hypertension (HP:0001409)1.82398489
89Eosinophilia (HP:0001880)1.81075619
90Abnormal rod and cone electroretinograms (HP:0008323)1.77739236
91Tinnitus (HP:0000360)1.77632584
92Abnormality of eosinophils (HP:0001879)1.77496001
93Bone marrow hypocellularity (HP:0005528)1.75403253
94Congenital sensorineural hearing impairment (HP:0008527)1.73875691
95Abnormality of the columella (HP:0009929)1.73232549
96Pulmonary fibrosis (HP:0002206)1.70768546
97Epistaxis (HP:0000421)1.70493214
98IgM deficiency (HP:0002850)1.68525679
99Premature graying of hair (HP:0002216)1.68473127
100Impaired proprioception (HP:0010831)1.63100413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.91766299
2TRIM284.15235819
3MKNK13.22364475
4TAOK32.69080212
5SIK32.61931277
6MAP4K12.31261843
7INSRR2.28786330
8KIT2.27186338
9BRD42.18713712
10PLK22.10525942
11MARK32.06278206
12CDK121.81325102
13STK381.70967239
14NUAK11.69878118
15MKNK21.62657762
16TEC1.61774522
17TNK21.61539968
18PIK3CG1.52504857
19ZAK1.51220461
20MAPKAPK51.47315802
21STK38L1.39728050
22SRPK11.36706851
23BMPR1B1.28689998
24MAP4K21.27211061
25BCR1.23974126
26EIF2AK31.18708870
27PBK1.18039489
28WEE11.16811786
29MAP3K141.16692498
30ICK1.16192943
31BLK1.12382482
32BTK1.11813658
33IKBKB1.10953855
34ERBB31.09533166
35FRK1.04859085
36ATR1.04280853
37CDC71.04173564
38TXK1.02735400
39CDK70.99928101
40CAMK1G0.99241832
41RIPK40.98893112
42BUB10.98430541
43CCNB10.96945780
44SYK0.96614716
45CHEK20.92295910
46PNCK0.87320629
47BRSK20.86910761
48NEK20.86757762
49FES0.86112582
50TYK20.84853672
51CHEK10.80811993
52MAP3K130.80769253
53ZAP700.80626152
54RPS6KB20.80143082
55ACVR1B0.79786808
56BRAF0.77418085
57ABL20.75738006
58MAPK110.72878392
59OXSR10.72860341
60MAPK130.71192289
61BMPR20.71097246
62TESK10.70673370
63MAPKAPK30.69266971
64RPS6KA50.69159866
65CDK20.68654968
66PKN10.68256536
67ITK0.60375252
68CDK40.60366963
69GRK60.59254665
70LYN0.58772141
71DYRK1A0.58103443
72SIK20.57866447
73JAK30.57032265
74ATM0.56873690
75CDK10.56520354
76NEK60.54213747
77CAMKK20.53979386
78TBK10.52425295
79CSF1R0.51853843
80FLT30.51405685
81HCK0.48099894
82MAPK40.47383990
83PLK30.44934461
84MAPK10.44307140
85PLK10.43909948
86DYRK30.43381267
87NME20.41732385
88PRKCQ0.41335201
89PDK10.40810640
90CDK80.40791433
91MATK0.40680964
92CAMK1D0.40517152
93CDK60.40186431
94AKT30.38842861
95BCKDK0.37835812
96FGR0.37746027
97TRPM70.37434095
98MAP2K30.36505764
99DDR20.34397873
100LCK0.34176403

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.34989457
2Homologous recombination_Homo sapiens_hsa034403.17888218
3Base excision repair_Homo sapiens_hsa034102.98417619
4Non-homologous end-joining_Homo sapiens_hsa034502.96609659
5Fanconi anemia pathway_Homo sapiens_hsa034602.90490019
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44177803
7Nucleotide excision repair_Homo sapiens_hsa034202.40232267
8Allograft rejection_Homo sapiens_hsa053302.23547294
9RNA transport_Homo sapiens_hsa030132.15991227
10Fatty acid biosynthesis_Homo sapiens_hsa000612.05308196
11Mismatch repair_Homo sapiens_hsa034301.97230218
12Autoimmune thyroid disease_Homo sapiens_hsa053201.93927200
13Asthma_Homo sapiens_hsa053101.93337894
14Graft-versus-host disease_Homo sapiens_hsa053321.83476437
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68145575
16RNA degradation_Homo sapiens_hsa030181.67345623
17Olfactory transduction_Homo sapiens_hsa047401.65251613
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58309713
19Basal transcription factors_Homo sapiens_hsa030221.56825993
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.52352291
21Acute myeloid leukemia_Homo sapiens_hsa052211.49084548
22Herpes simplex infection_Homo sapiens_hsa051681.48841846
23Primary immunodeficiency_Homo sapiens_hsa053401.48727378
24Cell cycle_Homo sapiens_hsa041101.42784006
25Type I diabetes mellitus_Homo sapiens_hsa049401.41554805
26Spliceosome_Homo sapiens_hsa030401.39965305
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32206565
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30124139
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24555500
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22814122
31Antigen processing and presentation_Homo sapiens_hsa046121.20414738
32Influenza A_Homo sapiens_hsa051641.19169521
33B cell receptor signaling pathway_Homo sapiens_hsa046621.19025954
34Systemic lupus erythematosus_Homo sapiens_hsa053221.18573816
35Platelet activation_Homo sapiens_hsa046111.18012512
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12752103
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11851478
38Measles_Homo sapiens_hsa051621.11542351
39Hematopoietic cell lineage_Homo sapiens_hsa046401.09218594
40Pyrimidine metabolism_Homo sapiens_hsa002401.08378169
41Regulation of autophagy_Homo sapiens_hsa041401.07927265
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05122247
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.04232621
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99626897
45Leishmaniasis_Homo sapiens_hsa051400.98845708
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97523756
47Fatty acid metabolism_Homo sapiens_hsa012120.94349748
48Viral carcinogenesis_Homo sapiens_hsa052030.93069740
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91271445
50T cell receptor signaling pathway_Homo sapiens_hsa046600.87724730
51Other glycan degradation_Homo sapiens_hsa005110.86973277
52Proteasome_Homo sapiens_hsa030500.83787757
53mRNA surveillance pathway_Homo sapiens_hsa030150.82427189
54Purine metabolism_Homo sapiens_hsa002300.81765395
55Inositol phosphate metabolism_Homo sapiens_hsa005620.79503102
56Non-small cell lung cancer_Homo sapiens_hsa052230.78149393
57Taste transduction_Homo sapiens_hsa047420.77137320
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75133478
59Osteoclast differentiation_Homo sapiens_hsa043800.74696954
60RNA polymerase_Homo sapiens_hsa030200.73377417
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.73161867
62Lysine degradation_Homo sapiens_hsa003100.73129268
63Oocyte meiosis_Homo sapiens_hsa041140.71374704
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70992166
65Legionellosis_Homo sapiens_hsa051340.69828597
66Viral myocarditis_Homo sapiens_hsa054160.67638639
67Phototransduction_Homo sapiens_hsa047440.66756119
68African trypanosomiasis_Homo sapiens_hsa051430.65035163
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64811013
70Selenocompound metabolism_Homo sapiens_hsa004500.64001052
71Hepatitis B_Homo sapiens_hsa051610.61472240
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59648153
73Toxoplasmosis_Homo sapiens_hsa051450.59316182
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.57855306
75Alcoholism_Homo sapiens_hsa050340.57356791
76Dorso-ventral axis formation_Homo sapiens_hsa043200.56739287
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.52134236
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48926330
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46064613
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44570619
81Tuberculosis_Homo sapiens_hsa051520.40746508
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40157631
83Pentose phosphate pathway_Homo sapiens_hsa000300.39920752
84mTOR signaling pathway_Homo sapiens_hsa041500.39467618
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38058865
86N-Glycan biosynthesis_Homo sapiens_hsa005100.37669918
87Shigellosis_Homo sapiens_hsa051310.37591945
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37461861
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37141353
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.36804287
91p53 signaling pathway_Homo sapiens_hsa041150.35523279
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34065232
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33288343
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32319580
95Chronic myeloid leukemia_Homo sapiens_hsa052200.31883398
96Pancreatic cancer_Homo sapiens_hsa052120.30776459
97Ether lipid metabolism_Homo sapiens_hsa005650.30482256
98Malaria_Homo sapiens_hsa051440.30336934
99Fatty acid degradation_Homo sapiens_hsa000710.29434543
100Glutathione metabolism_Homo sapiens_hsa004800.29425121

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