ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	6.56757114
2	negative regulation of multicellular organism growth (GO:0040015)	6.31569511
3	sex differentiation (GO:0007548)	5.84893141
4	kynurenine metabolic process (GO:0070189)	5.70057811
5	tryptophan catabolic process (GO:0006569)	5.48791464
6	indole-containing compound catabolic process (GO:0042436)	5.48791464
7	indolalkylamine catabolic process (GO:0046218)	5.48791464
8	regulation of establishment of cell polarity (GO:2000114)	5.36319320
9	cytoplasmic mRNA processing body assembly (GO:0033962)	4.98231565
10	tryptophan metabolic process (GO:0006568)	4.74945317
11	piRNA metabolic process (GO:0034587)	4.74145515
12	regulation of MHC class I biosynthetic process (GO:0045343)	4.72436346
13	indolalkylamine metabolic process (GO:0006586)	4.58847920
14	behavioral response to nicotine (GO:0035095)	4.41654590
15	ADP metabolic process (GO:0046031)	4.40758528
16	regulation of establishment or maintenance of cell polarity (GO:0032878)	4.38430048
17	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.31628302
18	regulation of action potential (GO:0098900)	4.10204520
19	DNA methylation involved in gamete generation (GO:0043046)	4.06653380
20	cholesterol catabolic process (GO:0006707)	4.04927937
21	sterol catabolic process (GO:0016127)	4.04927937
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.94614325
23	cellular ketone body metabolic process (GO:0046950)	3.81026480
24	L-fucose catabolic process (GO:0042355)	3.74695077
25	fucose catabolic process (GO:0019317)	3.74695077
26	L-fucose metabolic process (GO:0042354)	3.74695077
27	synapsis (GO:0007129)	3.71704250
28	amino acid salvage (GO:0043102)	3.67912780
29	L-methionine salvage (GO:0071267)	3.67912780
30	L-methionine biosynthetic process (GO:0071265)	3.67912780
31	cilium or flagellum-dependent cell motility (GO:0001539)	3.66583402
32	indole-containing compound metabolic process (GO:0042430)	3.60121416
33	amine catabolic process (GO:0009310)	3.51691223
34	cellular biogenic amine catabolic process (GO:0042402)	3.51691223
35	ketone body metabolic process (GO:1902224)	3.48294726
36	cerebellar Purkinje cell differentiation (GO:0021702)	3.47899167
37	synaptic transmission, cholinergic (GO:0007271)	3.47567902
38	positive regulation of vasculogenesis (GO:2001214)	3.47338271
39	male meiosis I (GO:0007141)	3.44264429
40	detection of light stimulus involved in sensory perception (GO:0050962)	3.43885053
41	detection of light stimulus involved in visual perception (GO:0050908)	3.43885053
42	negative regulation of mast cell activation (GO:0033004)	3.41698137
43	aromatic amino acid family catabolic process (GO:0009074)	3.35955879
44	NAD biosynthetic process (GO:0009435)	3.32638311
45	negative regulation of type 2 immune response (GO:0002829)	3.31273317
46	epithelial cilium movement (GO:0003351)	3.27771144
47	regulation of gene silencing by RNA (GO:0060966)	3.27084842
48	regulation of posttranscriptional gene silencing (GO:0060147)	3.27084842
49	regulation of gene silencing by miRNA (GO:0060964)	3.27084842
50	nucleoside diphosphate catabolic process (GO:0009134)	3.26741145
51	response to pheromone (GO:0019236)	3.26215087
52	regulation of interleukin-13 production (GO:0032656)	3.26194395
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.25305160
54	rRNA catabolic process (GO:0016075)	3.14287749
55	acrosome assembly (GO:0001675)	3.14190259
56	cilium movement (GO:0003341)	3.12250457
57	male meiosis (GO:0007140)	3.05971016
58	bile acid biosynthetic process (GO:0006699)	3.04808151
59	neural tube formation (GO:0001841)	3.02564245
60	benzene-containing compound metabolic process (GO:0042537)	3.01836988
61	signal peptide processing (GO:0006465)	3.00681913
62	methionine biosynthetic process (GO:0009086)	2.99949268
63	axonemal dynein complex assembly (GO:0070286)	2.97390124
64	estrogen biosynthetic process (GO:0006703)	2.97318435
65	neuronal action potential propagation (GO:0019227)	2.96779060
66	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.96476491
67	regulation of interleukin-5 production (GO:0032674)	2.96212978
68	cellular response to ATP (GO:0071318)	2.95931725
69	neuronal action potential (GO:0019228)	2.93707599
70	alternative mRNA splicing, via spliceosome (GO:0000380)	2.91723644
71	behavioral response to ethanol (GO:0048149)	2.91402123
72	aromatic amino acid family metabolic process (GO:0009072)	2.91295311
73	somite rostral/caudal axis specification (GO:0032525)	2.91100233
74	stress granule assembly (GO:0034063)	2.88876362
75	regulation of vasculogenesis (GO:2001212)	2.88715365
76	centrosome duplication (GO:0051298)	2.87089166
77	lipid particle organization (GO:0034389)	2.86585511
78	auditory receptor cell stereocilium organization (GO:0060088)	2.85002688
79	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.84911469
80	photoreceptor cell maintenance (GO:0045494)	2.82440352
81	serotonin metabolic process (GO:0042428)	2.80580692
82	reciprocal DNA recombination (GO:0035825)	2.80147313
83	reciprocal meiotic recombination (GO:0007131)	2.80147313
84	seminiferous tubule development (GO:0072520)	2.77843705
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.77122316
86	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.76649338
87	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.75746691
88	regulation of sarcomere organization (GO:0060297)	2.72668255
89	meiotic chromosome segregation (GO:0045132)	2.72383015
90	primary amino compound metabolic process (GO:1901160)	2.71341436
91	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.67020306
92	meiosis I (GO:0007127)	2.66992754
93	multicellular organism reproduction (GO:0032504)	2.63915524
94	dopamine transport (GO:0015872)	2.62984238
95	reflex (GO:0060004)	2.60249344
96	centriole replication (GO:0007099)	2.58136144
97	sulfation (GO:0051923)	2.55582743
98	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.53326561
99	platelet dense granule organization (GO:0060155)	2.49597164
100	NADH dehydrogenase complex assembly (GO:0010257)	2.49554293

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.65314089
2	* VDR_22108803_ChIP-Seq_LS180_Human	3.56911227
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.47318814
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.27503659
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.14082022
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93300754
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.85966901
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76325346
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.73298901
10	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63840519
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58150261
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40372426
13	* ER_23166858_ChIP-Seq_MCF-7_Human	2.26002913
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.19808949
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14519750
16	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13163761
17	BCAT_22108803_ChIP-Seq_LS180_Human	2.03982888
18	P300_19829295_ChIP-Seq_ESCs_Human	1.93460198
19	EWS_26573619_Chip-Seq_HEK293_Human	1.88464779
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86136375
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75049711
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72249217
23	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.71717161
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69980897
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69111310
26	STAT3_23295773_ChIP-Seq_U87_Human	1.67369148
27	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64698971
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62294437
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62092195
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58646393
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55537031
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.54856251
33	TCF4_23295773_ChIP-Seq_U87_Human	1.54341521
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50383975
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.46472171
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45895125
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43396036
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43129383
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43129383
40	AR_25329375_ChIP-Seq_VCAP_Human	1.42983001
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41960203
42	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40289163
43	* CBP_20019798_ChIP-Seq_JUKART_Human	1.40289163
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38806351
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38444269
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36018653
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.32875704
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32493941
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32220993
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31667757
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30232920
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29891916
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28461166
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27469741
55	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.25595062
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25048089
57	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24671687
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23858942
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23071797
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22658786
61	* NCOR_22424771_ChIP-Seq_293T_Human	1.22047320
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.21127616
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.19490205
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18962756
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18962756
66	AR_20517297_ChIP-Seq_VCAP_Human	1.16210031
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14659499
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14523658
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14523658
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14479474
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12704096
72	DROSHA_22980978_ChIP-Seq_HELA_Human	1.12693877
73	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.12219065
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11305297
75	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10555091
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08390406
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08341478
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07697497
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.06700902
80	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04985084
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03414690
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03236905
83	ERA_21632823_ChIP-Seq_H3396_Human	1.03071896
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02119220
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01280667
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01062697
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99363441
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98405752
89	* OCT4_20526341_ChIP-Seq_ESCs_Human	0.98120502
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97790926
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97600183
92	KDM2B_26808549_Chip-Seq_REH_Human	0.97010301
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96575030
94	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96394368
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.96073697
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95590260
97	* TBL1_22424771_ChIP-Seq_293T_Human	0.95398862
98	NFYB_21822215_ChIP-Seq_K562_Human	0.94667009
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94228242
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.93950483

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.31140906
2	MP0003011_delayed_dark_adaptation	3.20075322
3	MP0001986_abnormal_taste_sensitivity	3.13219883
4	MP0003252_abnormal_bile_duct	3.12818070
5	MP0001968_abnormal_touch/_nociception	3.09017564
6	MP0002736_abnormal_nociception_after	3.04816741
7	MP0003136_yellow_coat_color	2.92496705
8	MP0008877_abnormal_DNA_methylation	2.70481478
9	MP0005551_abnormal_eye_electrophysiolog	2.52879428
10	MP0003195_calcinosis	2.44222733
11	MP0002837_dystrophic_cardiac_calcinosis	2.37205729
12	MP0000372_irregular_coat_pigmentation	2.33880696
13	MP0002102_abnormal_ear_morphology	2.32571361
14	MP0005646_abnormal_pituitary_gland	2.30720111
15	MP0001501_abnormal_sleep_pattern	2.14204013
16	MP0004147_increased_porphyrin_level	2.11152093
17	MP0009046_muscle_twitch	2.08638441
18	MP0005253_abnormal_eye_physiology	2.07694036
19	MP0009745_abnormal_behavioral_response	2.07173085
20	MP0005174_abnormal_tail_pigmentation	2.00790217
21	MP0005171_absent_coat_pigmentation	1.95959008
22	MP0003646_muscle_fatigue	1.94428995
23	MP0000427_abnormal_hair_cycle	1.92781245
24	MP0003718_maternal_effect	1.80884958
25	MP0006072_abnormal_retinal_apoptosis	1.68867250
26	MP0004885_abnormal_endolymph	1.64616083
27	MP0002272_abnormal_nervous_system	1.58727023
28	MP0005410_abnormal_fertilization	1.56360085
29	MP0001486_abnormal_startle_reflex	1.51564191
30	MP0002638_abnormal_pupillary_reflex	1.49879750
31	MP0002938_white_spotting	1.48118207
32	MP0002876_abnormal_thyroid_physiology	1.45735663
33	MP0000371_diluted_coat_color	1.44581876
34	MP0004043_abnormal_pH_regulation	1.43755937
35	MP0005075_abnormal_melanosome_morpholog	1.42073846
36	MP0000383_abnormal_hair_follicle	1.41984525
37	MP0003806_abnormal_nucleotide_metabolis	1.41826743
38	MP0006276_abnormal_autonomic_nervous	1.41655723
39	MP0000015_abnormal_ear_pigmentation	1.36616650
40	MP0002160_abnormal_reproductive_system	1.33536578
41	MP0002064_seizures	1.33232947
42	MP0008872_abnormal_physiological_respon	1.31605716
43	MP0008058_abnormal_DNA_repair	1.29275026
44	MP0005647_abnormal_sex_gland	1.29274395
45	MP0010386_abnormal_urinary_bladder	1.29105350
46	MP0004133_heterotaxia	1.20862711
47	MP0002095_abnormal_skin_pigmentation	1.20021805
48	MP0001485_abnormal_pinna_reflex	1.14709064
49	MP0003698_abnormal_male_reproductive	1.13106894
50	MP0006292_abnormal_olfactory_placode	1.12963116
51	MP0002928_abnormal_bile_duct	1.12045936
52	MP0003950_abnormal_plasma_membrane	1.11475596
53	MP0002733_abnormal_thermal_nociception	1.11461856
54	MP0005645_abnormal_hypothalamus_physiol	1.10188397
55	MP0002210_abnormal_sex_determination	1.09989544
56	MP0004142_abnormal_muscle_tone	1.06302996
57	MP0004924_abnormal_behavior	1.05378115
58	MP0005386_behavior/neurological_phenoty	1.05378115
59	MP0004145_abnormal_muscle_electrophysio	1.04654966
60	MP0005389_reproductive_system_phenotype	1.04611486
61	MP0002234_abnormal_pharynx_morphology	1.04171303
62	MP0000631_abnormal_neuroendocrine_gland	1.04017425
63	MP0000653_abnormal_sex_gland	1.02657284
64	MP0001929_abnormal_gametogenesis	1.01608350
65	MP0005085_abnormal_gallbladder_physiolo	1.00527956
66	MP0002067_abnormal_sensory_capabilities	1.00356175
67	MP0006035_abnormal_mitochondrial_morpho	0.97576624
68	MP0002572_abnormal_emotion/affect_behav	0.97294248
69	MP0001324_abnormal_eye_pigmentation	0.96978685
70	MP0001764_abnormal_homeostasis	0.96677804
71	MP0002138_abnormal_hepatobiliary_system	0.95738767
72	MP0008995_early_reproductive_senescence	0.95573717
73	MP0006036_abnormal_mitochondrial_physio	0.94201731
74	MP0001970_abnormal_pain_threshold	0.92979645
75	MP0001145_abnormal_male_reproductive	0.92529992
76	MP0001529_abnormal_vocalization	0.92044377
77	MP0002163_abnormal_gland_morphology	0.91935046
78	MP0002229_neurodegeneration	0.89613173
79	MP0004215_abnormal_myocardial_fiber	0.89534863
80	MP0002735_abnormal_chemical_nociception	0.89526517
81	MP0008875_abnormal_xenobiotic_pharmacok	0.89234962
82	MP0002693_abnormal_pancreas_physiology	0.87390663
83	MP0003137_abnormal_impulse_conducting	0.87305781
84	MP0005084_abnormal_gallbladder_morpholo	0.85256637
85	MP0008057_abnormal_DNA_replication	0.82465731
86	MP0003635_abnormal_synaptic_transmissio	0.79601258
87	MP0005083_abnormal_biliary_tract	0.79311919
88	MP0002075_abnormal_coat/hair_pigmentati	0.75734818
89	MP0001664_abnormal_digestion	0.75308138
90	MP0005195_abnormal_posterior_eye	0.75056621
91	MP0005334_abnormal_fat_pad	0.74868513
92	MP0003186_abnormal_redox_activity	0.74786143
93	MP0002653_abnormal_ependyma_morphology	0.74579864
94	MP0005636_abnormal_mineral_homeostasis	0.74477905
95	MP0005377_hearing/vestibular/ear_phenot	0.72015158
96	MP0003878_abnormal_ear_physiology	0.72015158
97	MP0000026_abnormal_inner_ear	0.72008888
98	MP0005395_other_phenotype	0.70915351
99	MP0004381_abnormal_hair_follicle	0.70857723
100	MP0005391_vision/eye_phenotype	0.70671265

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.03394104
2	Progressive cerebellar ataxia (HP:0002073)	5.08692367
3	Gaze-evoked nystagmus (HP:0000640)	4.52573716
4	Action tremor (HP:0002345)	4.46159650
5	Pancreatic cysts (HP:0001737)	4.29913004
6	Pendular nystagmus (HP:0012043)	4.22999332
7	Dysmetric saccades (HP:0000641)	4.22822352
8	Pancreatic fibrosis (HP:0100732)	3.78779084
9	Absence seizures (HP:0002121)	3.69237824
10	True hermaphroditism (HP:0010459)	3.66695248
11	Prostate neoplasm (HP:0100787)	3.57071415
12	Abnormality of midbrain morphology (HP:0002418)	3.35514736
13	Molar tooth sign on MRI (HP:0002419)	3.35514736
14	Dialeptic seizures (HP:0011146)	3.28714369
15	Focal seizures (HP:0007359)	3.23099581
16	Congenital stationary night blindness (HP:0007642)	3.21998213
17	Nephronophthisis (HP:0000090)	3.18548818
18	Keratoconus (HP:0000563)	2.99573794
19	Increased corneal curvature (HP:0100692)	2.99573794
20	Protruding tongue (HP:0010808)	2.96974789
21	Abnormality of the renal cortex (HP:0011035)	2.96262643
22	Attenuation of retinal blood vessels (HP:0007843)	2.94104217
23	Abnormality of the hepatic vasculature (HP:0006707)	2.94047993
24	Abnormality of macular pigmentation (HP:0008002)	2.89362227
25	Hyperventilation (HP:0002883)	2.88209807
26	Focal motor seizures (HP:0011153)	2.86695889
27	Abolished electroretinogram (ERG) (HP:0000550)	2.84861315
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.81003501
29	Absent/shortened dynein arms (HP:0200106)	2.81003501
30	Severe visual impairment (HP:0001141)	2.80312501
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.78432241
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.78432241
33	Urinary bladder sphincter dysfunction (HP:0002839)	2.77364143
34	Abnormal ciliary motility (HP:0012262)	2.77326578
35	Abnormality of the renal medulla (HP:0100957)	2.73291923
36	Chronic hepatic failure (HP:0100626)	2.70010935
37	Cystic liver disease (HP:0006706)	2.66052596
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.62992902
39	Congenital sensorineural hearing impairment (HP:0008527)	2.59474751
40	Sclerocornea (HP:0000647)	2.51728267
41	Clumsiness (HP:0002312)	2.49877358
42	Type II lissencephaly (HP:0007260)	2.44593239
43	Postural instability (HP:0002172)	2.43978068
44	Impaired smooth pursuit (HP:0007772)	2.43661467
45	Fair hair (HP:0002286)	2.42315673
46	Febrile seizures (HP:0002373)	2.40760121
47	Decreased central vision (HP:0007663)	2.37984254
48	Bony spicule pigmentary retinopathy (HP:0007737)	2.33076483
49	Chorioretinal atrophy (HP:0000533)	2.31982104
50	Atonic seizures (HP:0010819)	2.31378060
51	Rib fusion (HP:0000902)	2.23245661
52	Impaired vibratory sensation (HP:0002495)	2.21747468
53	Oculomotor apraxia (HP:0000657)	2.21102629
54	Dysdiadochokinesis (HP:0002075)	2.19451319
55	Tubular atrophy (HP:0000092)	2.19167690
56	Renal cortical cysts (HP:0000803)	2.18715891
57	Abnormality of alanine metabolism (HP:0010916)	2.17378979
58	Hyperalaninemia (HP:0003348)	2.17378979
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17378979
60	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.16792271
61	Hypoplasia of the fovea (HP:0007750)	2.16792271
62	Inability to walk (HP:0002540)	2.16761392
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16012232
64	Postural tremor (HP:0002174)	2.15522619
65	Male pseudohermaphroditism (HP:0000037)	2.14722158
66	Concave nail (HP:0001598)	2.14420164
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10610529
68	Limb ataxia (HP:0002070)	2.09866952
69	Medial flaring of the eyebrow (HP:0010747)	2.08958072
70	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.08201815
71	Retinitis pigmentosa (HP:0000510)	2.06479831
72	Abnormal biliary tract physiology (HP:0012439)	2.05279594
73	Bile duct proliferation (HP:0001408)	2.05279594
74	Bilateral microphthalmos (HP:0007633)	2.03010055
75	Furrowed tongue (HP:0000221)	1.97884378
76	Broad-based gait (HP:0002136)	1.95713548
77	Abnormality of the fovea (HP:0000493)	1.92467661
78	Small hand (HP:0200055)	1.91339392
79	Increased CSF lactate (HP:0002490)	1.90473281
80	Abnormality of the prostate (HP:0008775)	1.89524450
81	Congenital hepatic fibrosis (HP:0002612)	1.89022714
82	Acute necrotizing encephalopathy (HP:0006965)	1.88983434
83	Congenital, generalized hypertrichosis (HP:0004540)	1.88776609
84	Absent speech (HP:0001344)	1.88624234
85	Hypochromic microcytic anemia (HP:0004840)	1.87282330
86	Generalized hypopigmentation of hair (HP:0011358)	1.84481939
87	Retinal dysplasia (HP:0007973)	1.84423473
88	Postaxial foot polydactyly (HP:0001830)	1.82337340
89	Abnormal drinking behavior (HP:0030082)	1.81574362
90	Polydipsia (HP:0001959)	1.81574362
91	Mitochondrial inheritance (HP:0001427)	1.81393032
92	Anencephaly (HP:0002323)	1.80135881
93	Hemiparesis (HP:0001269)	1.79915198
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79422271
95	Abnormality of ocular smooth pursuit (HP:0000617)	1.78623110
96	Abnormal protein glycosylation (HP:0012346)	1.78098719
97	Abnormal glycosylation (HP:0012345)	1.78098719
98	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78098719
99	Abnormal protein N-linked glycosylation (HP:0012347)	1.78098719
100	Acute encephalopathy (HP:0006846)	1.77906568

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.22148130
2	CDK19	5.80623688
3	OXSR1	3.47533984
4	BMPR1B	3.07774319
5	PINK1	3.01770261
6	ZAK	2.74867422
7	ADRBK2	2.54242937
8	GRK1	2.42812543
9	ACVR1B	2.27081564
10	INSRR	2.27062253
11	TXK	2.15616349
12	MAP4K2	2.04248319
13	TAOK3	2.01886366
14	NUAK1	1.84686405
15	WNK3	1.78838183
16	CASK	1.76515126
17	WNK4	1.75523724
18	MAPK13	1.35354553
19	TNK2	1.33904110
20	MAP3K7	1.30095525
21	MKNK2	1.27068913
22	STK3	1.08764418
23	MUSK	1.04437869
24	PLK4	1.02533596
25	ADRBK1	1.01548255
26	STK38L	0.99927165
27	TLK1	0.98744058
28	PNCK	0.97822092
29	MAP3K4	0.95352586
30	TGFBR1	0.92086186
31	MARK3	0.88811571
32	DAPK2	0.87368967
33	NTRK3	0.86193586
34	SIK2	0.84817379
35	TIE1	0.81724779
36	STK39	0.80528340
37	MAPKAPK5	0.79773221
38	PTK2B	0.78360423
39	WEE1	0.73318310
40	PRKCG	0.72928101
41	BCR	0.71050914
42	CHEK2	0.68168047
43	PRKCE	0.67636359
44	MARK1	0.66662642
45	PIK3CG	0.65387076
46	TEC	0.64879125
47	CCNB1	0.63556008
48	FER	0.63331781
49	NEK2	0.60877647
50	PLK2	0.60370511
51	MKNK1	0.59014073
52	BRSK2	0.54253450
53	VRK1	0.54057257
54	GRK7	0.52569643
55	DYRK2	0.51777241
56	ATR	0.51394592
57	MAPK15	0.48172023
58	MAP2K6	0.46912596
59	MST4	0.46212564
60	ALK	0.45632776
61	PDK2	0.45327094
62	NME1	0.44126164
63	PAK3	0.44065713
64	RPS6KB2	0.43404533
65	CAMK2A	0.42322386
66	MAPKAPK3	0.40397772
67	PRKACA	0.40088134
68	STK38	0.40074204
69	CSNK1G2	0.39343750
70	PKN1	0.38422567
71	PHKG2	0.38401525
72	PHKG1	0.38401525
73	TRIM28	0.38348991
74	OBSCN	0.38235692
75	LATS1	0.37535700
76	NTRK2	0.36856084
77	RPS6KA5	0.36811664
78	CSNK1G1	0.36415392
79	PRKG1	0.35613281
80	CSNK1G3	0.35262935
81	PLK1	0.35001456
82	STK11	0.34941170
83	MATK	0.34351538
84	KIT	0.34309561
85	MAP2K1	0.33847121
86	PRKCQ	0.33732707
87	CDK3	0.33470474
88	TNIK	0.33080740
89	EIF2AK3	0.32392608
90	GRK5	0.31930068
91	VRK2	0.30257611
92	CSNK1A1L	0.30217074
93	PLK3	0.30172592
94	CDK8	0.30031323
95	BCKDK	0.29864148
96	ATM	0.29339944
97	PRKAA2	0.28217883
98	MAP2K7	0.27858586
99	CSNK1A1	0.27724391
100	PIK3CA	0.27607520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.11513465
2	Butanoate metabolism_Homo sapiens_hsa00650	2.68440250
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.50003599
4	Phototransduction_Homo sapiens_hsa04744	2.48973981
5	RNA polymerase_Homo sapiens_hsa03020	2.44031308
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41315164
7	Olfactory transduction_Homo sapiens_hsa04740	2.19037812
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14407736
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.14175202
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.12044980
11	Homologous recombination_Homo sapiens_hsa03440	2.10948109
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.07801171
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00548579
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99961526
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92748817
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.90482090
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.88459294
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83349849
19	Nicotine addiction_Homo sapiens_hsa05033	1.80850739
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.77811693
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72962183
22	Caffeine metabolism_Homo sapiens_hsa00232	1.71849349
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71698400
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68503310
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.64830633
26	Taste transduction_Homo sapiens_hsa04742	1.63234720
27	Retinol metabolism_Homo sapiens_hsa00830	1.61195794
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57893703
29	ABC transporters_Homo sapiens_hsa02010	1.52299418
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41624292
31	Propanoate metabolism_Homo sapiens_hsa00640	1.40590885
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.37630761
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.34905528
34	Morphine addiction_Homo sapiens_hsa05032	1.21153076
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16223758
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.15064026
37	Basal transcription factors_Homo sapiens_hsa03022	1.12403163
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11848144
39	One carbon pool by folate_Homo sapiens_hsa00670	1.09498138
40	Purine metabolism_Homo sapiens_hsa00230	1.09185205
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07643310
42	Parkinsons disease_Homo sapiens_hsa05012	1.07064991
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04887433
44	Peroxisome_Homo sapiens_hsa04146	1.02959288
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.96888743
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96553918
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94537396
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94421371
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92698530
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88378005
51	GABAergic synapse_Homo sapiens_hsa04727	0.86640368
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84211031
53	Salivary secretion_Homo sapiens_hsa04970	0.83359303
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.83301058
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82240264
56	Serotonergic synapse_Homo sapiens_hsa04726	0.79206114
57	Huntingtons disease_Homo sapiens_hsa05016	0.78573875
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.77033132
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76888654
60	RNA degradation_Homo sapiens_hsa03018	0.75692634
61	Circadian entrainment_Homo sapiens_hsa04713	0.75443166
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.74373511
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73964318
64	Protein export_Homo sapiens_hsa03060	0.71052427
65	Fatty acid degradation_Homo sapiens_hsa00071	0.70484315
66	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70152892
67	Metabolic pathways_Homo sapiens_hsa01100	0.68604754
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.68483976
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.66831046
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66420084
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66182769
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.65564687
73	Alzheimers disease_Homo sapiens_hsa05010	0.63761103
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.60004073
75	Histidine metabolism_Homo sapiens_hsa00340	0.55651980
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54876569
77	Glutathione metabolism_Homo sapiens_hsa00480	0.54810435
78	Insulin secretion_Homo sapiens_hsa04911	0.53987610
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.53703174
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.51974832
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48026080
82	Gastric acid secretion_Homo sapiens_hsa04971	0.46479148
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.45084526
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44691338
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43452550
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42391458
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41102492
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40163638
89	Circadian rhythm_Homo sapiens_hsa04710	0.40096831
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39335913
91	Nucleotide excision repair_Homo sapiens_hsa03420	0.37713666
92	Mineral absorption_Homo sapiens_hsa04978	0.35118152
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32904285
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.28908288
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28717615
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.27801747
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27121157
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25457605
99	Regulation of autophagy_Homo sapiens_hsa04140	0.24470756
100	Asthma_Homo sapiens_hsa05310	0.23987237

HERC2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »