ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.83889702
2	response to pheromone (GO:0019236)	4.17999675
3	kynurenine metabolic process (GO:0070189)	4.13076621
4	L-fucose metabolic process (GO:0042354)	4.08822259
5	L-fucose catabolic process (GO:0042355)	4.08822259
6	fucose catabolic process (GO:0019317)	4.08822259
7	indole-containing compound catabolic process (GO:0042436)	4.00843685
8	indolalkylamine catabolic process (GO:0046218)	4.00843685
9	tryptophan catabolic process (GO:0006569)	4.00843685
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79455673
11	indolalkylamine metabolic process (GO:0006586)	3.69045210
12	neuronal action potential (GO:0019228)	3.63609423
13	tryptophan metabolic process (GO:0006568)	3.58380480
14	cellular ketone body metabolic process (GO:0046950)	3.52273660
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.45282225
16	gamma-aminobutyric acid transport (GO:0015812)	3.35665047
17	primary amino compound metabolic process (GO:1901160)	3.30382837
18	indole-containing compound metabolic process (GO:0042430)	3.29210686
19	serotonin metabolic process (GO:0042428)	3.24798049
20	behavioral response to ethanol (GO:0048149)	3.24240272
21	sulfation (GO:0051923)	3.23444638
22	neural tube formation (GO:0001841)	3.21160834
23	synaptic transmission, cholinergic (GO:0007271)	3.19422029
24	ketone body metabolic process (GO:1902224)	3.17745354
25	regulation of action potential (GO:0098900)	3.12198533
26	epithelial cilium movement (GO:0003351)	3.11799188
27	nephron epithelium morphogenesis (GO:0072088)	3.09050891
28	nephron tubule morphogenesis (GO:0072078)	3.09050891
29	nonmotile primary cilium assembly (GO:0035058)	3.01356895
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.96516301
31	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.94988144
32	rRNA catabolic process (GO:0016075)	2.94093722
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.93056734
34	pyrimidine nucleobase catabolic process (GO:0006208)	2.91257496
35	cilium or flagellum-dependent cell motility (GO:0001539)	2.90786880
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.87678915
37	detection of light stimulus involved in visual perception (GO:0050908)	2.87678915
38	negative regulation of telomere maintenance (GO:0032205)	2.86086485
39	reflex (GO:0060004)	2.85890659
40	negative regulation of mast cell activation (GO:0033004)	2.84290693
41	water-soluble vitamin biosynthetic process (GO:0042364)	2.80743232
42	spinal cord motor neuron differentiation (GO:0021522)	2.78433655
43	positive regulation of action potential (GO:0045760)	2.76468416
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.74402995
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.74402995
46	NADH dehydrogenase complex assembly (GO:0010257)	2.74402995
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74343524
48	startle response (GO:0001964)	2.73920014
49	kidney morphogenesis (GO:0060993)	2.71573059
50	DNA deamination (GO:0045006)	2.71429571
51	regulation of gene silencing by miRNA (GO:0060964)	2.70790491
52	regulation of gene silencing by RNA (GO:0060966)	2.70790491
53	regulation of posttranscriptional gene silencing (GO:0060147)	2.70790491
54	cornea development in camera-type eye (GO:0061303)	2.69965014
55	platelet dense granule organization (GO:0060155)	2.69145667
56	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.68496907
57	regulation of translation, ncRNA-mediated (GO:0045974)	2.68496907
58	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.68496907
59	cAMP catabolic process (GO:0006198)	2.67613300
60	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.66525086
61	piRNA metabolic process (GO:0034587)	2.66139843
62	amine catabolic process (GO:0009310)	2.65048821
63	cellular biogenic amine catabolic process (GO:0042402)	2.65048821
64	cilium movement (GO:0003341)	2.64941743
65	protein complex biogenesis (GO:0070271)	2.64894893
66	cilium morphogenesis (GO:0060271)	2.64496572
67	somite development (GO:0061053)	2.62639341
68	cilium organization (GO:0044782)	2.61295833
69	postsynaptic membrane organization (GO:0001941)	2.60303825
70	action potential (GO:0001508)	2.60113367
71	alanine transport (GO:0032328)	2.59041823
72	regulation of mesoderm development (GO:2000380)	2.57858762
73	membrane depolarization during action potential (GO:0086010)	2.56491214
74	protein import into peroxisome matrix (GO:0016558)	2.55492610
75	cilium assembly (GO:0042384)	2.55432723
76	nucleobase catabolic process (GO:0046113)	2.55240846
77	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.52703762
78	transmission of nerve impulse (GO:0019226)	2.51242681
79	photoreceptor cell development (GO:0042461)	2.51213580
80	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.50423510
81	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.50007231
82	protein-cofactor linkage (GO:0018065)	2.49754441
83	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.49196161
84	cellular response to ATP (GO:0071318)	2.45287948
85	mitochondrial respiratory chain complex assembly (GO:0033108)	2.45226320
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.45118061
87	axoneme assembly (GO:0035082)	2.44343077
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.44004540
89	glycerophospholipid catabolic process (GO:0046475)	2.42790840
90	parturition (GO:0007567)	2.42096720
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.41971031
92	protein polyglutamylation (GO:0018095)	2.41376725
93	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.40541535
94	proline transport (GO:0015824)	2.39832525
95	oxidative demethylation (GO:0070989)	2.39348558
96	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.38525248
97	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.38206996
98	renal tubule morphogenesis (GO:0061333)	2.36954568
99	hindbrain development (GO:0030902)	2.36912933
100	protein localization to synapse (GO:0035418)	2.36700075

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.86664123
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.01991442
3	VDR_22108803_ChIP-Seq_LS180_Human	3.42602694
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.03826174
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.02192187
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60467577
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51979274
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28020490
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24417847
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.11349164
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03993891
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96058524
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.95169776
14	FUS_26573619_Chip-Seq_HEK293_Human	1.93848902
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.93809968
16	EWS_26573619_Chip-Seq_HEK293_Human	1.92448292
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89104667
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.85786228
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.85421238
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84764387
21	P300_19829295_ChIP-Seq_ESCs_Human	1.84653534
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.80946195
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66931739
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.60959718
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59868321
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58409641
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55736883
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55213656
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55151255
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.53335610
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.52692176
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49710391
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49194587
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49134641
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48781951
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47966214
37	STAT3_23295773_ChIP-Seq_U87_Human	1.47937527
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46859216
39	AR_25329375_ChIP-Seq_VCAP_Human	1.46308318
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.45400973
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43801310
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.42336927
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41869528
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40338892
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.40318857
46	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39737913
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37815327
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35703287
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35543145
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35543145
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35519814
52	DROSHA_22980978_ChIP-Seq_HELA_Human	1.35461645
53	TCF4_23295773_ChIP-Seq_U87_Human	1.34069605
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33826869
55	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32177526
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30536643
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.30344861
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30344861
59	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30059509
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.26250265
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24694138
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23099916
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23040325
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22259350
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20070962
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18813847
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18813847
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18739144
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18534475
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.18430367
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17829783
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17584704
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17584704
74	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17048341
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15561138
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14893134
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14805914
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13022746
79	TP53_16413492_ChIP-PET_HCT116_Human	1.12710443
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12644538
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.11282211
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09367220
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08202391
84	NCOR_22424771_ChIP-Seq_293T_Human	1.05876212
85	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05426588
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04724295
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03556516
88	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03344380
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03168903
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02753131
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01439203
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01069875
93	AR_20517297_ChIP-Seq_VCAP_Human	1.00656810
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99628856
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99313307
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99017453
97	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97549176
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97549176
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97141664
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97077139

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.08029176
2	MP0003195_calcinosis	2.43105354
3	MP0005551_abnormal_eye_electrophysiolog	2.42077863
4	MP0000569_abnormal_digit_pigmentation	2.41258613
5	MP0008877_abnormal_DNA_methylation	2.36712952
6	MP0002653_abnormal_ependyma_morphology	2.28669245
7	MP0001968_abnormal_touch/_nociception	2.25610681
8	MP0002102_abnormal_ear_morphology	2.17578546
9	MP0003646_muscle_fatigue	2.16512753
10	MP0004142_abnormal_muscle_tone	2.13677559
11	MP0009745_abnormal_behavioral_response	2.12108523
12	MP0009046_muscle_twitch	2.09148281
13	MP0004133_heterotaxia	2.01682225
14	MP0004885_abnormal_endolymph	1.90742786
15	MP0006292_abnormal_olfactory_placode	1.86149353
16	MP0002272_abnormal_nervous_system	1.86134562
17	MP0003787_abnormal_imprinting	1.79530562
18	MP0003880_abnormal_central_pattern	1.79053810
19	MP0001485_abnormal_pinna_reflex	1.78794143
20	MP0002837_dystrophic_cardiac_calcinosis	1.77231256
21	MP0001986_abnormal_taste_sensitivity	1.76422106
22	MP0002638_abnormal_pupillary_reflex	1.73573565
23	MP0008872_abnormal_physiological_respon	1.71049494
24	MP0003011_delayed_dark_adaptation	1.70877561
25	MP0000427_abnormal_hair_cycle	1.69434309
26	MP0008875_abnormal_xenobiotic_pharmacok	1.68690799
27	MP0006276_abnormal_autonomic_nervous	1.68088060
28	MP0002064_seizures	1.67626010
29	MP0002736_abnormal_nociception_after	1.66826970
30	MP0006072_abnormal_retinal_apoptosis	1.65142426
31	MP0002938_white_spotting	1.61861657
32	MP0000631_abnormal_neuroendocrine_gland	1.59357629
33	MP0002572_abnormal_emotion/affect_behav	1.58383091
34	MP0004742_abnormal_vestibular_system	1.55247635
35	MP0004043_abnormal_pH_regulation	1.55035171
36	MP0002876_abnormal_thyroid_physiology	1.54912393
37	MP0005646_abnormal_pituitary_gland	1.50451266
38	MP0002735_abnormal_chemical_nociception	1.50098266
39	MP0001501_abnormal_sleep_pattern	1.49147944
40	MP0005253_abnormal_eye_physiology	1.46536459
41	MP0009379_abnormal_foot_pigmentation	1.46269438
42	MP0005645_abnormal_hypothalamus_physiol	1.45731235
43	MP0004145_abnormal_muscle_electrophysio	1.43827782
44	MP0002733_abnormal_thermal_nociception	1.43814926
45	MP0001486_abnormal_startle_reflex	1.43613641
46	MP0000372_irregular_coat_pigmentation	1.42936616
47	MP0003635_abnormal_synaptic_transmissio	1.41701968
48	MP0005174_abnormal_tail_pigmentation	1.38837424
49	MP0004147_increased_porphyrin_level	1.38257205
50	MP0001970_abnormal_pain_threshold	1.37969938
51	MP0003283_abnormal_digestive_organ	1.36290293
52	MP0002557_abnormal_social/conspecific_i	1.36012551
53	MP0002063_abnormal_learning/memory/cond	1.33858003
54	MP0002067_abnormal_sensory_capabilities	1.32169673
55	MP0005084_abnormal_gallbladder_morpholo	1.30531584
56	MP0003878_abnormal_ear_physiology	1.26068040
57	MP0005377_hearing/vestibular/ear_phenot	1.26068040
58	MP0000778_abnormal_nervous_system	1.25664114
59	MP0002163_abnormal_gland_morphology	1.24194064
60	MP0010386_abnormal_urinary_bladder	1.22661601
61	MP0004924_abnormal_behavior	1.22541790
62	MP0005386_behavior/neurological_phenoty	1.22541790
63	MP0002928_abnormal_bile_duct	1.21650470
64	MP0001919_abnormal_reproductive_system	1.20850189
65	MP0002734_abnormal_mechanical_nocicepti	1.20357636
66	MP0003890_abnormal_embryonic-extraembry	1.20147302
67	MP0005389_reproductive_system_phenotype	1.18048926
68	MP0000566_synostosis	1.16089788
69	MP0005195_abnormal_posterior_eye	1.14610778
70	MP0005423_abnormal_somatic_nervous	1.13989853
71	MP0002277_abnormal_respiratory_mucosa	1.13412771
72	MP0002234_abnormal_pharynx_morphology	1.12591552
73	MP0004130_abnormal_muscle_cell	1.08410699
74	MP0002160_abnormal_reproductive_system	1.06532158
75	MP0000026_abnormal_inner_ear	1.05611834
76	MP0001529_abnormal_vocalization	1.04906611
77	MP0002095_abnormal_skin_pigmentation	1.02057131
78	MP0002752_abnormal_somatic_nervous	0.98666466
79	MP0000383_abnormal_hair_follicle	0.98543404
80	MP0001905_abnormal_dopamine_level	0.95568473
81	MP0003137_abnormal_impulse_conducting	0.94608340
82	MP0001324_abnormal_eye_pigmentation	0.93810367
83	MP0002184_abnormal_innervation	0.92811136
84	MP0001440_abnormal_grooming_behavior	0.92778770
85	MP0003119_abnormal_digestive_system	0.92673897
86	MP0005379_endocrine/exocrine_gland_phen	0.89864966
87	MP0003122_maternal_imprinting	0.89789886
88	MP0005085_abnormal_gallbladder_physiolo	0.88835932
89	MP0000955_abnormal_spinal_cord	0.86767112
90	MP0001873_stomach_inflammation	0.86002853
91	MP0001293_anophthalmia	0.85465208
92	MP0001963_abnormal_hearing_physiology	0.84471704
93	MP0000230_abnormal_systemic_arterial	0.84030346
94	MP0005448_abnormal_energy_balance	0.83808790
95	MP0003121_genomic_imprinting	0.82525493
96	MP0002882_abnormal_neuron_morphology	0.81737658
97	MP0005171_absent_coat_pigmentation	0.80891070
98	MP0001984_abnormal_olfaction	0.80090725
99	MP0005167_abnormal_blood-brain_barrier	0.78059141
100	MP0003698_abnormal_male_reproductive	0.77457023

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.70513887
2	Molar tooth sign on MRI (HP:0002419)	4.56609147
3	Abnormality of midbrain morphology (HP:0002418)	4.56609147
4	Pancreatic fibrosis (HP:0100732)	4.45177053
5	True hermaphroditism (HP:0010459)	4.26459131
6	Nephronophthisis (HP:0000090)	4.14303986
7	Congenital stationary night blindness (HP:0007642)	3.85385847
8	Hyperventilation (HP:0002883)	3.46366892
9	Abnormality of the renal medulla (HP:0100957)	3.41008339
10	Chronic hepatic failure (HP:0100626)	3.15186804
11	Cystic liver disease (HP:0006706)	3.06865047
12	Medial flaring of the eyebrow (HP:0010747)	3.06091102
13	Type II lissencephaly (HP:0007260)	3.04347304
14	Abnormality of the renal cortex (HP:0011035)	3.00084300
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.93699047
16	Abnormality of alanine metabolism (HP:0010916)	2.93699047
17	Hyperalaninemia (HP:0003348)	2.93699047
18	Concave nail (HP:0001598)	2.89964865
19	Congenital, generalized hypertrichosis (HP:0004540)	2.89398787
20	Tubular atrophy (HP:0000092)	2.88815818
21	Sclerocornea (HP:0000647)	2.81280159
22	Attenuation of retinal blood vessels (HP:0007843)	2.77930980
23	Large for gestational age (HP:0001520)	2.77487701
24	Protruding tongue (HP:0010808)	2.77251147
25	Progressive cerebellar ataxia (HP:0002073)	2.76646632
26	Genetic anticipation (HP:0003743)	2.68792655
27	Birth length less than 3rd percentile (HP:0003561)	2.66258738
28	Inability to walk (HP:0002540)	2.64660973
29	Furrowed tongue (HP:0000221)	2.63045548
30	Gait imbalance (HP:0002141)	2.57406305
31	Abnormal drinking behavior (HP:0030082)	2.53127498
32	Polydipsia (HP:0001959)	2.53127498
33	Abolished electroretinogram (ERG) (HP:0000550)	2.48591694
34	Absent/shortened dynein arms (HP:0200106)	2.46864806
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.46864806
36	Patellar aplasia (HP:0006443)	2.44004634
37	Pendular nystagmus (HP:0012043)	2.41313694
38	Anencephaly (HP:0002323)	2.38198222
39	Increased corneal curvature (HP:0100692)	2.36955205
40	Keratoconus (HP:0000563)	2.36955205
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36484140
42	Congenital primary aphakia (HP:0007707)	2.33425250
43	Congenital hepatic fibrosis (HP:0002612)	2.32818206
44	Clumsiness (HP:0002312)	2.32775968
45	Lissencephaly (HP:0001339)	2.30754230
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.30641856
47	Male pseudohermaphroditism (HP:0000037)	2.28478536
48	Progressive inability to walk (HP:0002505)	2.26346501
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24108806
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.24108806
51	Nephrogenic diabetes insipidus (HP:0009806)	2.21373072
52	Gaze-evoked nystagmus (HP:0000640)	2.19372125
53	Focal motor seizures (HP:0011153)	2.16405710
54	Abnormality of the pons (HP:0007361)	2.13206280
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.10857227
56	Broad-based gait (HP:0002136)	2.09268829
57	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07771339
58	Abnormal biliary tract physiology (HP:0012439)	2.07335413
59	Bile duct proliferation (HP:0001408)	2.07335413
60	Decreased central vision (HP:0007663)	2.07220901
61	Cerebellar dysplasia (HP:0007033)	2.07168150
62	Decreased circulating renin level (HP:0003351)	2.04397536
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03007658
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.02945618
65	Hypoplasia of the pons (HP:0012110)	2.02910207
66	Postaxial foot polydactyly (HP:0001830)	1.98947042
67	Febrile seizures (HP:0002373)	1.96560942
68	Genital tract atresia (HP:0001827)	1.96166475
69	Optic nerve hypoplasia (HP:0000609)	1.95270303
70	Polyuria (HP:0000103)	1.93395560
71	Severe muscular hypotonia (HP:0006829)	1.93314166
72	Vaginal atresia (HP:0000148)	1.92895897
73	Poor coordination (HP:0002370)	1.92260721
74	Renal cortical cysts (HP:0000803)	1.91016624
75	Hyperglycinuria (HP:0003108)	1.90734869
76	Agitation (HP:0000713)	1.87894756
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.87892377
78	Limb dystonia (HP:0002451)	1.87390150
79	Optic disc pallor (HP:0000543)	1.87389311
80	Focal seizures (HP:0007359)	1.86086982
81	Fair hair (HP:0002286)	1.84347767
82	Acute necrotizing encephalopathy (HP:0006965)	1.83279710
83	Oligodactyly (hands) (HP:0001180)	1.82608365
84	Congenital sensorineural hearing impairment (HP:0008527)	1.82510392
85	3-Methylglutaconic aciduria (HP:0003535)	1.82372048
86	Tachypnea (HP:0002789)	1.80391316
87	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.80354082
88	Hemiparesis (HP:0001269)	1.80174173
89	Chorioretinal atrophy (HP:0000533)	1.80133095
90	Septo-optic dysplasia (HP:0100842)	1.79800106
91	Abnormal ciliary motility (HP:0012262)	1.79465929
92	Partial agenesis of the corpus callosum (HP:0001338)	1.79307282
93	Pachygyria (HP:0001302)	1.78069697
94	Dialeptic seizures (HP:0011146)	1.74081110
95	Mitochondrial inheritance (HP:0001427)	1.73918426
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73794218
97	Bilateral microphthalmos (HP:0007633)	1.71979164
98	Abnormal number of erythroid precursors (HP:0012131)	1.69771787
99	Prominent supraorbital ridges (HP:0000336)	1.69704386
100	Postaxial hand polydactyly (HP:0001162)	1.68795658

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09406610
2	INSRR	3.47670310
3	BMPR1B	3.42098468
4	ADRBK2	3.41039021
5	CASK	2.78320966
6	ACVR1B	2.78189555
7	WNK4	2.60868236
8	GRK1	2.45701142
9	WNK3	2.43960228
10	ZAK	2.35425768
11	PNCK	2.26791004
12	TLK1	2.22371368
13	MAPK13	2.22231779
14	PINK1	2.20294798
15	MARK1	1.99327054
16	TAOK3	1.79374129
17	MAP3K4	1.77635441
18	MAP4K2	1.76827577
19	TNIK	1.66043919
20	TXK	1.54403759
21	OXSR1	1.53231766
22	DAPK2	1.50747493
23	MAPK15	1.46586100
24	NUAK1	1.41832530
25	CAMKK2	1.40293142
26	TGFBR1	1.40084508
27	ADRBK1	1.37362324
28	NTRK3	1.35275740
29	DYRK2	1.33451142
30	STK39	1.22898054
31	NTRK2	1.15534912
32	PRKCG	1.15523550
33	MAP2K7	1.06205636
34	MKNK2	1.04266642
35	PAK3	1.03053580
36	SIK2	0.98763210
37	PIK3CA	0.98375502
38	WEE1	0.91684030
39	MUSK	0.82487533
40	TYRO3	0.81564699
41	NEK2	0.80647925
42	PKN1	0.80261001
43	PRKCE	0.78433621
44	PHKG2	0.78161045
45	PHKG1	0.78161045
46	TIE1	0.76912666
47	PRKCQ	0.74271404
48	STK11	0.72630785
49	MAPKAPK5	0.70233335
50	MAPKAPK3	0.68005201
51	CAMK2A	0.67243129
52	PTK2B	0.65963230
53	STK3	0.65055299
54	CDK19	0.62064777
55	RPS6KA5	0.61819714
56	CAMK1	0.60076887
57	MAP2K6	0.56104971
58	CHUK	0.54947111
59	CAMKK1	0.53941501
60	PRKACA	0.53880740
61	VRK1	0.52169163
62	OBSCN	0.50259089
63	RPS6KA6	0.48684776
64	PRKCZ	0.47458986
65	CSNK1G2	0.47023386
66	NME1	0.46872019
67	TEC	0.46640269
68	CAMK1D	0.43382117
69	DYRK1A	0.42835727
70	CAMK4	0.42639610
71	CHEK2	0.42625975
72	IRAK1	0.42532379
73	TRIM28	0.42468870
74	IKBKB	0.41662889
75	MAP2K4	0.41054637
76	PLK4	0.40831328
77	LIMK1	0.40257857
78	CSNK1A1	0.39251045
79	PLK2	0.38970591
80	BRSK2	0.38803931
81	MAP2K1	0.38075413
82	PRKCA	0.37449969
83	PRKG1	0.35811788
84	MKNK1	0.34825886
85	PRKCH	0.34534483
86	STK38L	0.34441612
87	WNK1	0.33952602
88	ERBB2	0.32735525
89	MAP3K9	0.32437276
90	BCKDK	0.32270742
91	ITK	0.32246863
92	SGK2	0.32239907
93	PRKAA2	0.32144528
94	CAMK1G	0.31727816
95	GRK7	0.31187735
96	BCR	0.31169661
97	CSNK1D	0.30796702
98	EPHA4	0.30739387
99	TAF1	0.30310407
100	CDK3	0.30056074

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.06096290
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.95962824
3	Nicotine addiction_Homo sapiens_hsa05033	2.85178500
4	Phototransduction_Homo sapiens_hsa04744	2.81860241
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.49103532
6	Butanoate metabolism_Homo sapiens_hsa00650	2.39607184
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.35560929
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.29572924
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.24388351
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.18438558
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.16916926
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09184406
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03963299
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93469873
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.92306629
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.76348630
17	Olfactory transduction_Homo sapiens_hsa04740	1.72706028
18	Parkinsons disease_Homo sapiens_hsa05012	1.72570658
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72268204
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69250790
21	Taste transduction_Homo sapiens_hsa04742	1.66171395
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63746794
23	Morphine addiction_Homo sapiens_hsa05032	1.61784080
24	Homologous recombination_Homo sapiens_hsa03440	1.44630826
25	Caffeine metabolism_Homo sapiens_hsa00232	1.39718345
26	RNA polymerase_Homo sapiens_hsa03020	1.33472491
27	ABC transporters_Homo sapiens_hsa02010	1.30168986
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.28422448
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27718022
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23412617
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.22907766
32	GABAergic synapse_Homo sapiens_hsa04727	1.22109539
33	Insulin secretion_Homo sapiens_hsa04911	1.21899392
34	Circadian entrainment_Homo sapiens_hsa04713	1.20642374
35	Huntingtons disease_Homo sapiens_hsa05016	1.20438887
36	Alzheimers disease_Homo sapiens_hsa05010	1.19959276
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19319970
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18698865
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17955417
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17597321
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16862139
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.15502974
43	Serotonergic synapse_Homo sapiens_hsa04726	1.13782677
44	Protein export_Homo sapiens_hsa03060	1.13450169
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10898809
46	Basal transcription factors_Homo sapiens_hsa03022	1.09503420
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08513281
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06334665
49	Sulfur relay system_Homo sapiens_hsa04122	1.01582278
50	Ribosome_Homo sapiens_hsa03010	1.00820308
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00239921
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.96615105
53	Cocaine addiction_Homo sapiens_hsa05030	0.93658341
54	Peroxisome_Homo sapiens_hsa04146	0.92103954
55	Retinol metabolism_Homo sapiens_hsa00830	0.91969435
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.86285766
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84928241
58	Propanoate metabolism_Homo sapiens_hsa00640	0.84172315
59	RNA degradation_Homo sapiens_hsa03018	0.79179708
60	Histidine metabolism_Homo sapiens_hsa00340	0.78180157
61	Salivary secretion_Homo sapiens_hsa04970	0.74922943
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74853209
63	One carbon pool by folate_Homo sapiens_hsa00670	0.74844018
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73087001
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73011945
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.72612526
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71861387
68	Cholinergic synapse_Homo sapiens_hsa04725	0.71124074
69	Amphetamine addiction_Homo sapiens_hsa05031	0.65372350
70	Gastric acid secretion_Homo sapiens_hsa04971	0.65157540
71	Long-term depression_Homo sapiens_hsa04730	0.64382317
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63538708
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62554729
74	Regulation of autophagy_Homo sapiens_hsa04140	0.59704947
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56629127
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.55953108
77	Asthma_Homo sapiens_hsa05310	0.55725669
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54605181
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.54006075
80	Mineral absorption_Homo sapiens_hsa04978	0.53667486
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52341318
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50626095
83	Metabolic pathways_Homo sapiens_hsa01100	0.48261673
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47736275
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47074073
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45083574
87	Axon guidance_Homo sapiens_hsa04360	0.44587295
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.43845674
89	Purine metabolism_Homo sapiens_hsa00230	0.41151157
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38594418
91	Sulfur metabolism_Homo sapiens_hsa00920	0.38020663
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.37875432
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37802754
94	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37065890
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35105077
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34205060
97	Bile secretion_Homo sapiens_hsa04976	0.33434205
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32052197
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30094541
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.29780516

HERC2P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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