HERC2P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin receptor signaling pathway (GO:0007210)9.16540020
2positive regulation of osteoblast proliferation (GO:0033690)8.24221394
3positive regulation of hair follicle development (GO:0051798)8.10720735
4positive regulation of hair cycle (GO:0042635)8.10720735
5negative regulation of interleukin-8 production (GO:0032717)8.06713067
6regulation of appetite (GO:0032098)7.36746417
7angiogenesis involved in wound healing (GO:0060055)7.25457870
8negative regulation of circadian rhythm (GO:0042754)6.76569502
9regulation of Cdc42 GTPase activity (GO:0043088)6.69890086
10negative regulation of calcium ion transport into cytosol (GO:0010523)6.63254982
11interferon-gamma production (GO:0032609)6.55447596
12hematopoietic stem cell proliferation (GO:0071425)6.19373986
13lymphangiogenesis (GO:0001946)6.12316785
14protein K48-linked deubiquitination (GO:0071108)5.99453985
15activated T cell proliferation (GO:0050798)5.98817424
16protein K63-linked deubiquitination (GO:0070536)5.96150056
17glycoprotein catabolic process (GO:0006516)5.92113709
18killing of cells of other organism (GO:0031640)5.66795651
19disruption of cells of other organism (GO:0044364)5.66795651
20righting reflex (GO:0060013)5.50808561
21glycerophospholipid catabolic process (GO:0046475)5.50583491
22regulation of hair follicle development (GO:0051797)5.26001645
23sulfation (GO:0051923)5.24428077
24cysteine metabolic process (GO:0006534)5.21780724
25thyroid hormone metabolic process (GO:0042403)5.17915255
26carnitine transmembrane transport (GO:1902603)5.15508383
27omega-hydroxylase P450 pathway (GO:0097267)5.13723386
28mucosal immune response (GO:0002385)4.90787287
29paraxial mesoderm development (GO:0048339)4.81734119
30granulocyte differentiation (GO:0030851)4.75002378
31amino-acid betaine transport (GO:0015838)4.71032179
32carnitine transport (GO:0015879)4.71032179
33defense response to fungus (GO:0050832)4.55953240
34organ or tissue specific immune response (GO:0002251)4.48076130
35organic cation transport (GO:0015695)4.45559113
36carnitine metabolic process (GO:0009437)4.38469308
37phospholipid translocation (GO:0045332)4.35492069
38lipid translocation (GO:0034204)4.35492069
39homocysteine metabolic process (GO:0050667)4.33844662
40filopodium assembly (GO:0046847)4.25637378
41negative regulation of metanephros development (GO:0072217)4.25153078
42negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.20263321
43retinal cone cell development (GO:0046549)4.13904741
44reflex (GO:0060004)4.13354539
45negative regulation of hormone biosynthetic process (GO:0032353)4.11434021
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.04080997
47protein sumoylation (GO:0016925)4.01130533
48startle response (GO:0001964)3.94472614
49DNA double-strand break processing (GO:0000729)3.93285157
50rRNA catabolic process (GO:0016075)3.92023869
51negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.90446259
52heparan sulfate proteoglycan metabolic process (GO:0030201)3.88131847
53flavonoid metabolic process (GO:0009812)3.86658285
54cilium or flagellum-dependent cell motility (GO:0001539)3.83959400
55regulation of sarcomere organization (GO:0060297)3.79003075
56quaternary ammonium group transport (GO:0015697)3.67969805
57positive regulation of epidermis development (GO:0045684)3.66271388
58regulation of hair cycle (GO:0042634)3.65487402
59sex differentiation (GO:0007548)3.61541016
60protein-cofactor linkage (GO:0018065)3.60928323
61negative regulation of hormone metabolic process (GO:0032351)3.60616139
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.58976191
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.58976191
64maturation of 5.8S rRNA (GO:0000460)3.57751856
65protein K6-linked ubiquitination (GO:0085020)3.54822548
66cell killing (GO:0001906)3.54360422
67regulation of steroid hormone biosynthetic process (GO:0090030)3.52725782
68positive regulation of vasculogenesis (GO:2001214)3.52418643
69regulation of osteoblast proliferation (GO:0033688)3.48113678
70androgen biosynthetic process (GO:0006702)3.47878081
71spindle assembly involved in mitosis (GO:0090307)3.47826808
72endothelial cell proliferation (GO:0001935)3.39749647
73positive regulation of cAMP-mediated signaling (GO:0043950)3.37338753
74indole-containing compound catabolic process (GO:0042436)3.37169029
75indolalkylamine catabolic process (GO:0046218)3.37169029
76tryptophan catabolic process (GO:0006569)3.37169029
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36914186
78regulation of B cell receptor signaling pathway (GO:0050855)3.36869266
79establishment of protein localization to Golgi (GO:0072600)3.36757456
80cellular ketone body metabolic process (GO:0046950)3.36128552
81negative regulation of mast cell activation (GO:0033004)3.33389866
82negative regulation by host of viral transcription (GO:0043922)3.31059021
83axon ensheathment in central nervous system (GO:0032291)3.31022433
84central nervous system myelination (GO:0022010)3.31022433
85amino-acid betaine metabolic process (GO:0006577)3.30461305
86regulation of mesenchymal cell apoptotic process (GO:2001053)3.28539867
87skin development (GO:0043588)3.28097029
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26043957
89myoblast migration (GO:0051451)3.18176775
90acrosome reaction (GO:0007340)3.11944619
91sex determination (GO:0007530)3.11677556
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.05754371
93phosphatidylinositol acyl-chain remodeling (GO:0036149)3.05433229
94positive regulation of oligodendrocyte differentiation (GO:0048714)3.03226208
95neuron fate determination (GO:0048664)3.03130464
96replication fork processing (GO:0031297)3.00269888
97response to fungus (GO:0009620)2.95794891
98ketone body metabolic process (GO:1902224)2.94941244
99positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.91963140
100protein K11-linked deubiquitination (GO:0035871)15.3099703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human6.85551553
2IKZF1_21737484_ChIP-ChIP_HCT116_Human4.78881016
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.43933280
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.44459621
5TAF15_26573619_Chip-Seq_HEK293_Human3.07202908
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.88765254
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80483089
8AR_21572438_ChIP-Seq_LNCaP_Human2.65360821
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63172353
10DROSHA_22980978_ChIP-Seq_HELA_Human2.49061485
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38253393
12EZH2_22144423_ChIP-Seq_EOC_Human2.34597390
13AR_25329375_ChIP-Seq_VCAP_Human2.29860372
14TP53_16413492_ChIP-PET_HCT116_Human2.22276339
15ER_23166858_ChIP-Seq_MCF-7_Human2.19505111
16LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94448917
17IGF1R_20145208_ChIP-Seq_DFB_Human1.93693043
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86812400
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86183232
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85761491
21ZNF274_21170338_ChIP-Seq_K562_Hela1.81964603
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.76086483
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74999584
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74301741
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66582233
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63480536
27SMAD4_21799915_ChIP-Seq_A2780_Human1.61849033
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59866384
29STAT3_23295773_ChIP-Seq_U87_Human1.57382505
30FOXA1_21572438_ChIP-Seq_LNCaP_Human1.56184657
31TP53_22573176_ChIP-Seq_HFKS_Human1.53209821
32P300_19829295_ChIP-Seq_ESCs_Human1.48655657
33CBP_20019798_ChIP-Seq_JUKART_Human1.45446481
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45446481
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44358616
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.44270048
37OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41604034
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.39183899
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39103557
40EWS_26573619_Chip-Seq_HEK293_Human1.34814917
41TCF4_23295773_ChIP-Seq_U87_Human1.32728251
42FUS_26573619_Chip-Seq_HEK293_Human1.31211277
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.30814140
44CDX2_22108803_ChIP-Seq_LS180_Human1.30219206
45FLI1_21867929_ChIP-Seq_TH2_Mouse1.29971532
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27929325
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.26472843
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.26460857
49VDR_22108803_ChIP-Seq_LS180_Human1.25488221
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24731583
51TP53_18474530_ChIP-ChIP_U2OS_Human1.23785251
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.23345834
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.23243511
54REST_21632747_ChIP-Seq_MESCs_Mouse1.23215982
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.20825849
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20628320
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20443750
58RUNX2_22187159_ChIP-Seq_PCA_Human1.20328806
59SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.19957586
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14304762
61JUN_21703547_ChIP-Seq_K562_Human1.13417161
62PHF8_20622853_ChIP-Seq_HELA_Human1.12667552
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11983831
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11882229
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11684251
66TCF4_22108803_ChIP-Seq_LS180_Human1.09143076
67TBL1_22424771_ChIP-Seq_293T_Human1.07434256
68BCAT_22108803_ChIP-Seq_LS180_Human1.07349183
69ERG_20517297_ChIP-Seq_VCAP_Human1.06946031
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06093587
71ERA_21632823_ChIP-Seq_H3396_Human1.04778417
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.03677332
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03203887
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03035670
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.03035670
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02560857
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01622562
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01085378
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00303736
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99663892
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99647170
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98344825
83AR_19668381_ChIP-Seq_PC3_Human0.97669610
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92836060
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91138562
86MYC_18940864_ChIP-ChIP_HL60_Human0.90659837
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.90475202
88ETV1_20927104_ChIP-Seq_GIST48_Human0.89936104
89MYC_19829295_ChIP-Seq_ESCs_Human0.89279285
90RBPJ_21746931_ChIP-Seq_IB4_Human0.88980965
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88756895
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.88053248
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87954185
94CBX2_22325352_ChIP-Seq_293T-Rex_Human0.87893880
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86375796
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84624699
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84201368
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.84171656
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82216183
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81956455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.77113580
2MP0002138_abnormal_hepatobiliary_system5.23322720
3MP0005310_abnormal_salivary_gland4.41320894
4MP0005670_abnormal_white_adipose4.34844512
5MP0008875_abnormal_xenobiotic_pharmacok4.23930608
6MP0002139_abnormal_hepatobiliary_system4.07611387
7MP0003806_abnormal_nucleotide_metabolis3.79876560
8MP0002254_reproductive_system_inflammat3.29151047
9MP0001984_abnormal_olfaction3.10881158
10MP0004043_abnormal_pH_regulation2.85686404
11MP0002735_abnormal_chemical_nociception2.21820373
12MP0001919_abnormal_reproductive_system2.09659446
13MP0000613_abnormal_salivary_gland2.07692821
14MP0005551_abnormal_eye_electrophysiolog2.02142622
15MP0002736_abnormal_nociception_after1.98411923
16MP0001879_abnormal_lymphatic_vessel1.87215574
17MP0005647_abnormal_sex_gland1.83180516
18MP0006276_abnormal_autonomic_nervous1.81837697
19MP0001873_stomach_inflammation1.80326239
20MP0003283_abnormal_digestive_organ1.76203827
21MP0002277_abnormal_respiratory_mucosa1.75880988
22MP0005389_reproductive_system_phenotype1.75116946
23MP0001968_abnormal_touch/_nociception1.71471467
24MP0001348_abnormal_lacrimal_gland1.69272863
25MP0005410_abnormal_fertilization1.68990587
26MP0002064_seizures1.66853621
27MP0009046_muscle_twitch1.59729624
28MP0009745_abnormal_behavioral_response1.57839054
29MP0006082_CNS_inflammation1.54554555
30MP0002876_abnormal_thyroid_physiology1.53493462
31MP0002234_abnormal_pharynx_morphology1.48854785
32MP0002006_tumorigenesis1.45601986
33MP0002970_abnormal_white_adipose1.44793699
34MP0000230_abnormal_systemic_arterial1.44479666
35MP0005187_abnormal_penis_morphology1.43042069
36MP0003718_maternal_effect1.37740508
37MP0001529_abnormal_vocalization1.36815956
38MP0002928_abnormal_bile_duct1.36199741
39MP0003878_abnormal_ear_physiology1.34282794
40MP0005377_hearing/vestibular/ear_phenot1.34282794
41MP0003315_abnormal_perineum_morphology1.30412737
42MP0001486_abnormal_startle_reflex1.23543508
43MP0005084_abnormal_gallbladder_morpholo1.22958500
44MP0005167_abnormal_blood-brain_barrier1.20814505
45MP0001905_abnormal_dopamine_level1.19565507
46MP0000569_abnormal_digit_pigmentation1.16249596
47MP0004142_abnormal_muscle_tone1.14972670
48MP0001970_abnormal_pain_threshold1.10743098
49MP0000383_abnormal_hair_follicle1.10591013
50MP0002734_abnormal_mechanical_nocicepti1.09594282
51MP0008961_abnormal_basal_metabolism1.09516797
52MP0003638_abnormal_response/metabolism_1.04475135
53MP0003195_calcinosis1.03656329
54MP0002572_abnormal_emotion/affect_behav1.01049260
55MP0010329_abnormal_lipoprotein_level0.99209620
56MP0003646_muscle_fatigue0.95458381
57MP0000566_synostosis0.89876462
58MP0003936_abnormal_reproductive_system0.89313055
59MP0004858_abnormal_nervous_system0.89022384
60MP0002272_abnormal_nervous_system0.88822990
61MP0000639_abnormal_adrenal_gland0.88177874
62MP0004924_abnormal_behavior0.87382531
63MP0005386_behavior/neurological_phenoty0.87382531
64MP0002269_muscular_atrophy0.83596892
65MP0003698_abnormal_male_reproductive0.83340783
66MP0000631_abnormal_neuroendocrine_gland0.81020104
67MP0005253_abnormal_eye_physiology0.80066320
68MP0002127_abnormal_cardiovascular_syste0.78780057
69MP0008569_lethality_at_weaning0.77884873
70MP0010678_abnormal_skin_adnexa0.75282643
71MP0001764_abnormal_homeostasis0.72350512
72MP0001440_abnormal_grooming_behavior0.70730682
73MP0005595_abnormal_vascular_smooth0.69398917
74MP0002210_abnormal_sex_determination0.69255615
75MP0002971_abnormal_brown_adipose0.69050773
76MP0005452_abnormal_adipose_tissue0.67706392
77MP0005360_urolithiasis0.66609401
78MP0004085_abnormal_heartbeat0.66226862
79MP0001986_abnormal_taste_sensitivity0.65452668
80MP0002938_white_spotting0.65244466
81MP0003724_increased_susceptibility_to0.64165339
82MP0008874_decreased_physiological_sensi0.62862868
83MP0002067_abnormal_sensory_capabilities0.62491944
84MP0002063_abnormal_learning/memory/cond0.62370040
85MP0003252_abnormal_bile_duct0.62006147
86MP0002229_neurodegeneration0.59720411
87MP0002069_abnormal_eating/drinking_beha0.56008860
88MP0005332_abnormal_amino_acid0.55869356
89MP0005195_abnormal_posterior_eye0.55649847
90MP0001346_abnormal_lacrimal_gland0.53967562
91MP0002075_abnormal_coat/hair_pigmentati0.51779844
92MP0001485_abnormal_pinna_reflex0.51651528
93MP0001145_abnormal_male_reproductive0.51233422
94MP0005171_absent_coat_pigmentation0.49596278
95MP0003635_abnormal_synaptic_transmissio0.49530533
96MP0000653_abnormal_sex_gland0.49337061
97MP0001929_abnormal_gametogenesis0.49271073
98MP0002118_abnormal_lipid_homeostasis0.47168312
99MP0010386_abnormal_urinary_bladder0.46871977
100MP0005164_abnormal_response_to0.46465645

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)6.40399104
2Lower limb hyperreflexia (HP:0002395)5.88662411
3Retrobulbar optic neuritis (HP:0100654)5.38355903
4Optic neuritis (HP:0100653)5.38355903
5Decreased circulating renin level (HP:0003351)4.92721817
6Bilateral sensorineural hearing impairment (HP:0008619)4.88415215
7Orchitis (HP:0100796)4.69963533
8Keratoconjunctivitis (HP:0001096)4.54855107
9Poikiloderma (HP:0001029)4.54574869
10Attenuation of retinal blood vessels (HP:0007843)3.77361164
11Congenital stationary night blindness (HP:0007642)3.77168606
12Hyperventilation (HP:0002883)3.76332807
13Abnormal pancreas size (HP:0012094)3.64833994
14Enlarged penis (HP:0000040)3.57302156
15Myositis (HP:0100614)3.56833093
16Abnormality of the pericardium (HP:0001697)3.56499871
17Bony spicule pigmentary retinopathy (HP:0007737)3.55887409
18True hermaphroditism (HP:0010459)3.54328935
19Hypoplasia of the uterus (HP:0000013)3.37490413
20Keratoconjunctivitis sicca (HP:0001097)3.31635124
21Gout (HP:0001997)3.30965782
22Unilateral renal agenesis (HP:0000122)3.09402633
23Abolished electroretinogram (ERG) (HP:0000550)3.07114324
24Male pseudohermaphroditism (HP:0000037)3.06033767
25Hyperglycinuria (HP:0003108)3.04871162
26Late onset (HP:0003584)3.02200355
27Pancreatic cysts (HP:0001737)2.90394719
28Abnormality of dentin (HP:0010299)2.88557276
29Gonadotropin excess (HP:0000837)2.78862015
30Preaxial foot polydactyly (HP:0001841)2.74148866
31Absent speech (HP:0001344)2.73253039
32Bicornuate uterus (HP:0000813)2.68778103
33Pancreatic fibrosis (HP:0100732)2.64111970
34Xanthomatosis (HP:0000991)2.53737099
35Abnormality of dental color (HP:0011073)2.53437303
36Polydipsia (HP:0001959)2.53160415
37Abnormal drinking behavior (HP:0030082)2.53160415
38Aplasia/hypoplasia of the uterus (HP:0008684)2.49249354
39Clumsiness (HP:0002312)2.48873073
40Tinnitus (HP:0000360)2.47858035
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46105974
42Amelogenesis imperfecta (HP:0000705)2.38130851
43Hydroxyprolinuria (HP:0003080)2.35859560
44Abnormality of proline metabolism (HP:0010907)2.35859560
45Bulbous nose (HP:0000414)2.34997729
46Mesangial abnormality (HP:0001966)2.32786995
47Basal ganglia calcification (HP:0002135)2.31365970
48Constricted visual fields (HP:0001133)2.31308724
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.31013375
50Abnormal biliary tract physiology (HP:0012439)2.29783423
51Bile duct proliferation (HP:0001408)2.29783423
52Ileus (HP:0002595)2.26626985
53Chronic hepatic failure (HP:0100626)2.23197760
54Hyperaldosteronism (HP:0000859)2.22589321
55Abnormality of renin-angiotensin system (HP:0000847)2.21858688
56Delayed closure of the anterior fontanelle (HP:0001476)2.21842888
57Spastic paraplegia (HP:0001258)2.20943283
58Anorexia (HP:0002039)2.19131791
59Anomalous pulmonary venous return (HP:0010772)2.18807235
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.18640092
61Craniofacial hyperostosis (HP:0004493)2.17338346
62Acne (HP:0001061)2.14804354
63Bicuspid aortic valve (HP:0001647)2.09456206
64Delayed puberty (HP:0000823)2.08575039
65Exocrine pancreatic insufficiency (HP:0001738)2.08330139
66Spastic tetraparesis (HP:0001285)2.02881965
67Paraplegia (HP:0010550)2.02238091
68Hyperkalemia (HP:0002153)2.01964493
69Atrioventricular block (HP:0001678)2.01083780
70Glucose intolerance (HP:0000833)2.00052455
71Abnormality of glycine metabolism (HP:0010895)1.99422929
72Abnormality of serine family amino acid metabolism (HP:0010894)1.99422929
73Retinal atrophy (HP:0001105)1.98335029
74Stage 5 chronic kidney disease (HP:0003774)1.96641303
75CNS demyelination (HP:0007305)1.95920765
76Hyperactive renin-angiotensin system (HP:0000841)1.95768645
77Breast carcinoma (HP:0003002)1.95240045
78Encephalitis (HP:0002383)1.91171919
79Abnormality of the pulmonary veins (HP:0011718)1.91145684
80Renovascular hypertension (HP:0100817)1.91035347
81Frequent falls (HP:0002359)1.90615354
82Oligomenorrhea (HP:0000876)1.89645635
83Abnormality of the left ventricular outflow tract (HP:0011103)1.88449750
84Subaortic stenosis (HP:0001682)1.88449750
85Bilateral microphthalmos (HP:0007633)1.87652668
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.87222665
87Absent/shortened dynein arms (HP:0200106)1.87222665
88Hypokalemia (HP:0002900)1.85992959
89Meckel diverticulum (HP:0002245)1.85136190
90Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85062922
91Abnormality of the carotid arteries (HP:0005344)1.83847066
92Limb hypertonia (HP:0002509)1.82890459
93Hemoptysis (HP:0002105)1.80847016
94Opisthotonus (HP:0002179)1.78807104
95Prolonged QT interval (HP:0001657)1.78430276
96Abnormality of the ileum (HP:0001549)1.76074229
97Abnormal glucose tolerance (HP:0001952)1.75787375
98Abnormal number of erythroid precursors (HP:0012131)1.75007013
99Vertigo (HP:0002321)1.74405117
100Absent radius (HP:0003974)1.71805511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.17049856
2WNK37.20610755
3TXK4.57902335
4PINK13.83324368
5ZAK3.00507806
6BLK2.81862311
7EEF2K2.68253505
8YES12.31376291
9MAPKAPK32.14348253
10CDK121.79763490
11FER1.70889268
12TRPM71.60211289
13MAPK131.59347048
14ADRBK21.51129531
15PRKCZ1.36507299
16STK391.31614113
17IRAK11.24195480
18PRKD31.23900558
19GRK11.17593746
20EIF2AK31.13847472
21STK38L1.08644886
22PLK41.07958523
23MAPKAPK51.04358520
24OXSR10.98075643
25EIF2AK20.97965343
26NTRK30.96994246
27CCNB10.95864197
28TAOK30.94914897
29BCKDK0.93052839
30TLK10.92753549
31CHEK20.90279817
32PIK3CA0.87009279
33MKNK10.86067294
34BUB10.84646135
35GRK70.82046570
36ADRBK10.74188435
37BMPR1B0.73231321
38CSK0.72935051
39MKNK20.71955159
40TTK0.68337903
41FLT30.62217116
42PRKG10.56169581
43PRKD20.56108595
44CSF1R0.53455220
45MARK10.53132940
46PRKCB0.52358980
47TGFBR20.52022149
48NEK10.50887017
49DYRK20.48877899
50WNK40.48225959
51KIT0.48018988
52PDK10.45778353
53PRKCA0.45235175
54PRKCH0.44876863
55RPS6KB20.42002130
56PKN20.39884447
57IGF1R0.39313091
58LIMK10.37731788
59CDK30.36141254
60MOS0.32444267
61CAMK10.32425318
62INSRR0.32174177
63PRKACA0.31594472
64PRKCG0.31287597
65MAP3K70.30606403
66MAPK150.30521353
67STK380.30502740
68MAPK110.30366913
69SIK20.30225801
70LMTK20.29799381
71PHKG10.29111860
72PHKG20.29111860
73CAMK1D0.27565890
74CAMK2A0.26087031
75PTK2B0.26051849
76RPS6KA50.25600983
77VRK10.25418975
78RPS6KA30.25178738
79GSK3A0.24583215
80ACVR1B0.23921480
81GSK3B0.23267126
82PRKAA20.22332628
83MAPK70.21891235
84PLK10.21134828
85CSNK1A10.20856514
86RPS6KA40.20685686
87AKT30.20151374
88INSR0.18160253
89NTRK20.17767111
90MAP2K10.17302177
91TIE10.16065304
92PRKDC0.15994123
93CDK10.15071541
94MAPK140.13968047
95PRKCE0.13879564
96MAPK10.13556811
97LATS10.12614176
98MAPK100.12452925
99PLK20.12052666
100PRKCQ0.11649697

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005316.05439823
2Selenocompound metabolism_Homo sapiens_hsa004503.93160171
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19307098
4Histidine metabolism_Homo sapiens_hsa003402.95807347
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81693478
6Butanoate metabolism_Homo sapiens_hsa006502.72343021
7Linoleic acid metabolism_Homo sapiens_hsa005912.46903620
8Propanoate metabolism_Homo sapiens_hsa006402.41784331
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.33428793
10Arachidonic acid metabolism_Homo sapiens_hsa005902.15685625
11Ether lipid metabolism_Homo sapiens_hsa005652.13350728
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.97985783
13Nicotine addiction_Homo sapiens_hsa050331.82351253
14Proteasome_Homo sapiens_hsa030501.78720122
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77515221
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.77494745
17Fatty acid biosynthesis_Homo sapiens_hsa000611.75103897
18Glycerolipid metabolism_Homo sapiens_hsa005611.72261196
19Calcium signaling pathway_Homo sapiens_hsa040201.67078312
20Salivary secretion_Homo sapiens_hsa049701.61575160
21Serotonergic synapse_Homo sapiens_hsa047261.60434664
22N-Glycan biosynthesis_Homo sapiens_hsa005101.59722640
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58349787
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.57883853
25Phototransduction_Homo sapiens_hsa047441.55851519
26Fat digestion and absorption_Homo sapiens_hsa049751.55267660
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55231236
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.51227743
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40087507
30Olfactory transduction_Homo sapiens_hsa047401.39714879
31Tryptophan metabolism_Homo sapiens_hsa003801.39187325
32Fanconi anemia pathway_Homo sapiens_hsa034601.37329767
33Fatty acid metabolism_Homo sapiens_hsa012121.30251038
34Glutathione metabolism_Homo sapiens_hsa004801.27474398
35Vitamin digestion and absorption_Homo sapiens_hsa049771.18514092
36Fatty acid degradation_Homo sapiens_hsa000711.11452410
37Dorso-ventral axis formation_Homo sapiens_hsa043201.10823473
38cAMP signaling pathway_Homo sapiens_hsa040241.09055439
39ABC transporters_Homo sapiens_hsa020101.07260644
40Homologous recombination_Homo sapiens_hsa034401.05925119
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.04840653
42Ovarian steroidogenesis_Homo sapiens_hsa049131.02506229
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01182593
44Peroxisome_Homo sapiens_hsa041460.99309889
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98844405
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96525131
47RNA transport_Homo sapiens_hsa030130.91192687
48Staphylococcus aureus infection_Homo sapiens_hsa051500.88616982
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.87691038
50Morphine addiction_Homo sapiens_hsa050320.82857735
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81085570
52Base excision repair_Homo sapiens_hsa034100.80084407
53RNA polymerase_Homo sapiens_hsa030200.79744508
54Huntingtons disease_Homo sapiens_hsa050160.78582747
55Oxytocin signaling pathway_Homo sapiens_hsa049210.77416595
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73937156
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.73637485
58Metabolic pathways_Homo sapiens_hsa011000.69932843
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67881348
60Lysine degradation_Homo sapiens_hsa003100.66280115
61One carbon pool by folate_Homo sapiens_hsa006700.65787806
62Oxidative phosphorylation_Homo sapiens_hsa001900.64730195
63Nitrogen metabolism_Homo sapiens_hsa009100.63118312
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62491020
65Arginine and proline metabolism_Homo sapiens_hsa003300.60470172
66DNA replication_Homo sapiens_hsa030300.57021913
67Cholinergic synapse_Homo sapiens_hsa047250.56816773
68beta-Alanine metabolism_Homo sapiens_hsa004100.54173920
69Taste transduction_Homo sapiens_hsa047420.49650004
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48809538
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48735271
72Parkinsons disease_Homo sapiens_hsa050120.46591315
73Gastric acid secretion_Homo sapiens_hsa049710.46236022
74Chemical carcinogenesis_Homo sapiens_hsa052040.44692154
75Retinol metabolism_Homo sapiens_hsa008300.42752955
76Purine metabolism_Homo sapiens_hsa002300.41614603
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35850661
78GABAergic synapse_Homo sapiens_hsa047270.35555392
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33410203
80Pyrimidine metabolism_Homo sapiens_hsa002400.28504227
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28410708
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28338065
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28226742
84Alzheimers disease_Homo sapiens_hsa050100.27327108
85Arginine biosynthesis_Homo sapiens_hsa002200.26619496
86Non-homologous end-joining_Homo sapiens_hsa034500.26050261
87Pancreatic secretion_Homo sapiens_hsa049720.25886882
88PPAR signaling pathway_Homo sapiens_hsa033200.24978703
89Protein digestion and absorption_Homo sapiens_hsa049740.24361676
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.23915060
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21884058
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21867647
93Tyrosine metabolism_Homo sapiens_hsa003500.21433926
94Starch and sucrose metabolism_Homo sapiens_hsa005000.17541679
95Pyruvate metabolism_Homo sapiens_hsa006200.15481237
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12952269
97Nucleotide excision repair_Homo sapiens_hsa034200.12546907
98Epstein-Barr virus infection_Homo sapiens_hsa051690.12084098
99RNA degradation_Homo sapiens_hsa030180.11251963
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11095221

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