ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.83548283
2	response to pheromone (GO:0019236)	4.80674719
3	kynurenine metabolic process (GO:0070189)	4.11654082
4	L-fucose metabolic process (GO:0042354)	4.09198452
5	L-fucose catabolic process (GO:0042355)	4.09198452
6	fucose catabolic process (GO:0019317)	4.09198452
7	indole-containing compound catabolic process (GO:0042436)	3.98267693
8	indolalkylamine catabolic process (GO:0046218)	3.98267693
9	tryptophan catabolic process (GO:0006569)	3.98267693
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79076405
11	neuronal action potential (GO:0019228)	3.69653130
12	indolalkylamine metabolic process (GO:0006586)	3.65958969
13	cellular ketone body metabolic process (GO:0046950)	3.55171752
14	tryptophan metabolic process (GO:0006568)	3.54624034
15	primary amino compound metabolic process (GO:1901160)	3.41767305
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.41338711
17	gamma-aminobutyric acid transport (GO:0015812)	3.36331960
18	serotonin metabolic process (GO:0042428)	3.35515128
19	indole-containing compound metabolic process (GO:0042430)	3.34243755
20	sulfation (GO:0051923)	3.26565977
21	behavioral response to ethanol (GO:0048149)	3.25543676
22	regulation of action potential (GO:0098900)	3.19938504
23	ketone body metabolic process (GO:1902224)	3.19897437
24	synaptic transmission, cholinergic (GO:0007271)	3.18931026
25	neural tube formation (GO:0001841)	3.17851709
26	nephron tubule morphogenesis (GO:0072078)	3.10527076
27	nephron epithelium morphogenesis (GO:0072088)	3.10527076
28	epithelial cilium movement (GO:0003351)	3.10159728
29	nonmotile primary cilium assembly (GO:0035058)	2.98804557
30	positive regulation of action potential (GO:0045760)	2.97023491
31	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.96860618
32	rRNA catabolic process (GO:0016075)	2.94710568
33	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.94535930
34	pyrimidine nucleobase catabolic process (GO:0006208)	2.94396731
35	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.92518712
36	cilium or flagellum-dependent cell motility (GO:0001539)	2.89482151
37	reflex (GO:0060004)	2.88175085
38	detection of light stimulus involved in visual perception (GO:0050908)	2.86054668
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.86054668
40	negative regulation of telomere maintenance (GO:0032205)	2.85329695
41	spinal cord motor neuron differentiation (GO:0021522)	2.83776694
42	negative regulation of mast cell activation (GO:0033004)	2.79852377
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.79841993
44	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.78477962
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75445662
46	NADH dehydrogenase complex assembly (GO:0010257)	2.75445662
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75445662
48	startle response (GO:0001964)	2.73226197
49	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.73145276
50	cAMP catabolic process (GO:0006198)	2.71687954
51	kidney morphogenesis (GO:0060993)	2.71037343
52	DNA deamination (GO:0045006)	2.70042970
53	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.69634242
54	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.69634242
55	regulation of translation, ncRNA-mediated (GO:0045974)	2.69634242
56	cornea development in camera-type eye (GO:0061303)	2.68703637
57	regulation of gene silencing by RNA (GO:0060966)	2.67130972
58	regulation of posttranscriptional gene silencing (GO:0060147)	2.67130972
59	regulation of gene silencing by miRNA (GO:0060964)	2.67130972
60	piRNA metabolic process (GO:0034587)	2.66644160
61	platelet dense granule organization (GO:0060155)	2.66244639
62	amine catabolic process (GO:0009310)	2.64495343
63	cellular biogenic amine catabolic process (GO:0042402)	2.64495343
64	somite development (GO:0061053)	2.64170905
65	cilium morphogenesis (GO:0060271)	2.63905817
66	protein complex biogenesis (GO:0070271)	2.63181931
67	cilium movement (GO:0003341)	2.63152904
68	action potential (GO:0001508)	2.62711154
69	regulation of mesoderm development (GO:2000380)	2.61612255
70	postsynaptic membrane organization (GO:0001941)	2.61590809
71	alanine transport (GO:0032328)	2.60450266
72	cilium organization (GO:0044782)	2.60337909
73	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.58747491
74	protein import into peroxisome matrix (GO:0016558)	2.58511384
75	membrane depolarization during action potential (GO:0086010)	2.57543463
76	nucleobase catabolic process (GO:0046113)	2.57049839
77	cilium assembly (GO:0042384)	2.54221831
78	transmission of nerve impulse (GO:0019226)	2.50920067
79	protein-cofactor linkage (GO:0018065)	2.50389085
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.50253616
81	photoreceptor cell development (GO:0042461)	2.50000913
82	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.48643998
83	cellular response to ATP (GO:0071318)	2.45735044
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.44839222
85	protein polyglutamylation (GO:0018095)	2.43643895
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.43357943
87	parturition (GO:0007567)	2.43146832
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.42634354
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.42107023
90	neuron maturation (GO:0042551)	2.41261054
91	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.40785510
92	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.40593624
93	proline transport (GO:0015824)	2.40570405
94	renal tubule morphogenesis (GO:0061333)	2.40318683
95	axoneme assembly (GO:0035082)	2.39917114
96	glycerophospholipid catabolic process (GO:0046475)	2.39258965
97	cell differentiation in spinal cord (GO:0021515)	2.37920423
98	oxidative demethylation (GO:0070989)	2.37651591
99	urinary tract smooth muscle contraction (GO:0014848)	2.37230766
100	hindbrain development (GO:0030902)	2.37118802

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.88726924
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.03541535
3	VDR_22108803_ChIP-Seq_LS180_Human	3.40851036
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.04298497
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.03774394
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60869611
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53204209
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28254810
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24814087
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.08434692
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00053217
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95294256
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.94775731
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.94675105
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93189069
16	FUS_26573619_Chip-Seq_HEK293_Human	1.91168747
17	EWS_26573619_Chip-Seq_HEK293_Human	1.90921533
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.85830501
19	P300_19829295_ChIP-Seq_ESCs_Human	1.84877109
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.84472366
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84190006
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.81603422
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67910361
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61313724
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60317381
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59800541
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57135693
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56436709
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.53086572
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.52300743
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52074269
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49486323
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49390428
34	STAT3_23295773_ChIP-Seq_U87_Human	1.48272829
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48005565
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47923492
37	AR_25329375_ChIP-Seq_VCAP_Human	1.47298478
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47177085
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46903005
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.45742140
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44134653
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42641678
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.42318556
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40282485
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39237757
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.38252945
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37840403
48	DROSHA_22980978_ChIP-Seq_HELA_Human	1.37507169
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35539235
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35499405
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35499405
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.34870693
53	TCF4_23295773_ChIP-Seq_U87_Human	1.33948335
54	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32763097
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31424497
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30872664
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30467507
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29161060
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.29161060
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25956798
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24736337
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24566806
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23571772
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22810699
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20810704
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.19539991
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18627900
68	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18430827
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18024174
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18024174
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.17627237
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16802441
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16802441
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15410842
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15375822
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15314416
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14686513
78	TP53_16413492_ChIP-PET_HCT116_Human	1.13729367
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12719013
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12375061
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.10387146
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09984007
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08440789
84	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06074259
85	NCOR_22424771_ChIP-Seq_293T_Human	1.05776169
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05276332
87	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04321028
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03565739
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03502610
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02569652
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01044318
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00919018
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00543692
94	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99815311
95	AR_20517297_ChIP-Seq_VCAP_Human	0.99772347
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98735529
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.98311471
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.98311471
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97472724
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97061400

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.09139801
2	MP0003195_calcinosis	2.45531648
3	MP0000569_abnormal_digit_pigmentation	2.43308827
4	MP0005551_abnormal_eye_electrophysiolog	2.40925768
5	MP0008877_abnormal_DNA_methylation	2.37698200
6	MP0002653_abnormal_ependyma_morphology	2.30113957
7	MP0001968_abnormal_touch/_nociception	2.26650913
8	MP0004142_abnormal_muscle_tone	2.15802966
9	MP0002102_abnormal_ear_morphology	2.14737909
10	MP0003646_muscle_fatigue	2.14451176
11	MP0009745_abnormal_behavioral_response	2.14373378
12	MP0009046_muscle_twitch	2.12392604
13	MP0004133_heterotaxia	2.04299725
14	MP0004885_abnormal_endolymph	1.92653169
15	MP0002272_abnormal_nervous_system	1.86709784
16	MP0006292_abnormal_olfactory_placode	1.81457924
17	MP0003787_abnormal_imprinting	1.80652992
18	MP0001485_abnormal_pinna_reflex	1.78475262
19	MP0003880_abnormal_central_pattern	1.77206689
20	MP0001986_abnormal_taste_sensitivity	1.76417809
21	MP0002837_dystrophic_cardiac_calcinosis	1.75518617
22	MP0002638_abnormal_pupillary_reflex	1.72380108
23	MP0008872_abnormal_physiological_respon	1.72013327
24	MP0002064_seizures	1.71210480
25	MP0002736_abnormal_nociception_after	1.68879000
26	MP0003011_delayed_dark_adaptation	1.67750748
27	MP0000427_abnormal_hair_cycle	1.66558650
28	MP0006276_abnormal_autonomic_nervous	1.66160477
29	MP0008875_abnormal_xenobiotic_pharmacok	1.65753009
30	MP0006072_abnormal_retinal_apoptosis	1.64527987
31	MP0002938_white_spotting	1.64115731
32	MP0002572_abnormal_emotion/affect_behav	1.59513139
33	MP0004043_abnormal_pH_regulation	1.58809758
34	MP0000631_abnormal_neuroendocrine_gland	1.58010595
35	MP0004742_abnormal_vestibular_system	1.57985650
36	MP0002876_abnormal_thyroid_physiology	1.52427859
37	MP0002735_abnormal_chemical_nociception	1.51677679
38	MP0005646_abnormal_pituitary_gland	1.51327114
39	MP0001501_abnormal_sleep_pattern	1.48204257
40	MP0009379_abnormal_foot_pigmentation	1.46911985
41	MP0005253_abnormal_eye_physiology	1.45561738
42	MP0001486_abnormal_startle_reflex	1.44597052
43	MP0004145_abnormal_muscle_electrophysio	1.44440174
44	MP0002733_abnormal_thermal_nociception	1.44401111
45	MP0005645_abnormal_hypothalamus_physiol	1.43490550
46	MP0003635_abnormal_synaptic_transmissio	1.43112757
47	MP0003283_abnormal_digestive_organ	1.40567081
48	MP0005174_abnormal_tail_pigmentation	1.39878652
49	MP0001970_abnormal_pain_threshold	1.38662594
50	MP0004147_increased_porphyrin_level	1.36943942
51	MP0002063_abnormal_learning/memory/cond	1.35668741
52	MP0000372_irregular_coat_pigmentation	1.35651676
53	MP0002557_abnormal_social/conspecific_i	1.35292533
54	MP0002067_abnormal_sensory_capabilities	1.33515311
55	MP0005084_abnormal_gallbladder_morpholo	1.29565787
56	MP0003878_abnormal_ear_physiology	1.25877153
57	MP0005377_hearing/vestibular/ear_phenot	1.25877153
58	MP0000778_abnormal_nervous_system	1.25521740
59	MP0002734_abnormal_mechanical_nocicepti	1.23091022
60	MP0002928_abnormal_bile_duct	1.22596555
61	MP0003890_abnormal_embryonic-extraembry	1.22101261
62	MP0010386_abnormal_urinary_bladder	1.21799292
63	MP0002163_abnormal_gland_morphology	1.21060632
64	MP0004924_abnormal_behavior	1.20718629
65	MP0005386_behavior/neurological_phenoty	1.20718629
66	MP0001919_abnormal_reproductive_system	1.18599369
67	MP0000566_synostosis	1.17650527
68	MP0005389_reproductive_system_phenotype	1.16546860
69	MP0005195_abnormal_posterior_eye	1.14659743
70	MP0002277_abnormal_respiratory_mucosa	1.14477189
71	MP0005423_abnormal_somatic_nervous	1.14147131
72	MP0004130_abnormal_muscle_cell	1.13460775
73	MP0002234_abnormal_pharynx_morphology	1.10453827
74	MP0000026_abnormal_inner_ear	1.06023245
75	MP0002160_abnormal_reproductive_system	1.05295021
76	MP0002095_abnormal_skin_pigmentation	1.00099721
77	MP0001529_abnormal_vocalization	0.99562645
78	MP0000383_abnormal_hair_follicle	0.99195400
79	MP0002752_abnormal_somatic_nervous	0.98432721
80	MP0003119_abnormal_digestive_system	0.96371471
81	MP0003137_abnormal_impulse_conducting	0.95301601
82	MP0001905_abnormal_dopamine_level	0.95155341
83	MP0001440_abnormal_grooming_behavior	0.93797091
84	MP0001324_abnormal_eye_pigmentation	0.93528036
85	MP0005085_abnormal_gallbladder_physiolo	0.93503945
86	MP0002184_abnormal_innervation	0.93188740
87	MP0003122_maternal_imprinting	0.89148031
88	MP0005379_endocrine/exocrine_gland_phen	0.88321591
89	MP0001873_stomach_inflammation	0.87731201
90	MP0000955_abnormal_spinal_cord	0.86751145
91	MP0005448_abnormal_energy_balance	0.86062075
92	MP0001293_anophthalmia	0.84997581
93	MP0000230_abnormal_systemic_arterial	0.84687238
94	MP0001963_abnormal_hearing_physiology	0.84277912
95	MP0002882_abnormal_neuron_morphology	0.82176454
96	MP0003121_genomic_imprinting	0.81758739
97	MP0001984_abnormal_olfaction	0.79711772
98	MP0005171_absent_coat_pigmentation	0.78385733
99	MP0008961_abnormal_basal_metabolism	0.77821872
100	MP0002229_neurodegeneration	0.77091640

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.68598818
2	Molar tooth sign on MRI (HP:0002419)	4.59083021
3	Abnormality of midbrain morphology (HP:0002418)	4.59083021
4	Pancreatic fibrosis (HP:0100732)	4.40449315
5	True hermaphroditism (HP:0010459)	4.24804015
6	Nephronophthisis (HP:0000090)	4.13974818
7	Congenital stationary night blindness (HP:0007642)	3.85007416
8	Hyperventilation (HP:0002883)	3.44865429
9	Abnormality of the renal medulla (HP:0100957)	3.41104728
10	Chronic hepatic failure (HP:0100626)	3.16352677
11	Cystic liver disease (HP:0006706)	3.05215722
12	Abnormality of alanine metabolism (HP:0010916)	3.04972751
13	Hyperalaninemia (HP:0003348)	3.04972751
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.04972751
15	Medial flaring of the eyebrow (HP:0010747)	3.01361560
16	Type II lissencephaly (HP:0007260)	2.97800628
17	Abnormality of the renal cortex (HP:0011035)	2.97623531
18	Congenital, generalized hypertrichosis (HP:0004540)	2.94047408
19	Tubular atrophy (HP:0000092)	2.87519157
20	Concave nail (HP:0001598)	2.87278965
21	Large for gestational age (HP:0001520)	2.86298111
22	Progressive cerebellar ataxia (HP:0002073)	2.81941197
23	Attenuation of retinal blood vessels (HP:0007843)	2.81746130
24	Sclerocornea (HP:0000647)	2.79496758
25	Protruding tongue (HP:0010808)	2.77422832
26	Genetic anticipation (HP:0003743)	2.75201788
27	Birth length less than 3rd percentile (HP:0003561)	2.70238784
28	Furrowed tongue (HP:0000221)	2.68058213
29	Inability to walk (HP:0002540)	2.66929437
30	Gait imbalance (HP:0002141)	2.54092194
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51657162
32	Absent/shortened dynein arms (HP:0200106)	2.51657162
33	Abnormal drinking behavior (HP:0030082)	2.51179458
34	Polydipsia (HP:0001959)	2.51179458
35	Abolished electroretinogram (ERG) (HP:0000550)	2.49946181
36	Patellar aplasia (HP:0006443)	2.45519153
37	Pendular nystagmus (HP:0012043)	2.44923619
38	Anencephaly (HP:0002323)	2.37171975
39	Keratoconus (HP:0000563)	2.37044183
40	Increased corneal curvature (HP:0100692)	2.37044183
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32604053
42	Clumsiness (HP:0002312)	2.32459729
43	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31975726
44	Congenital hepatic fibrosis (HP:0002612)	2.30339998
45	Congenital primary aphakia (HP:0007707)	2.29940572
46	Progressive inability to walk (HP:0002505)	2.29831708
47	Lissencephaly (HP:0001339)	2.27336629
48	Male pseudohermaphroditism (HP:0000037)	2.27170128
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.25750796
50	Abnormal respiratory epithelium morphology (HP:0012253)	2.25750796
51	Gaze-evoked nystagmus (HP:0000640)	2.19157224
52	Nephrogenic diabetes insipidus (HP:0009806)	2.17838091
53	Focal motor seizures (HP:0011153)	2.14705570
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10154988
55	Abnormality of the pons (HP:0007361)	2.10111388
56	Broad-based gait (HP:0002136)	2.08263364
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.06478550
58	Decreased central vision (HP:0007663)	2.05764807
59	Decreased circulating renin level (HP:0003351)	2.03047222
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02888024
61	Cerebellar dysplasia (HP:0007033)	2.02735116
62	Bile duct proliferation (HP:0001408)	2.01916268
63	Abnormal biliary tract physiology (HP:0012439)	2.01916268
64	Hypoplasia of the pons (HP:0012110)	1.99352516
65	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97048057
66	Febrile seizures (HP:0002373)	1.96136954
67	Postaxial foot polydactyly (HP:0001830)	1.95518899
68	Optic nerve hypoplasia (HP:0000609)	1.94939544
69	Severe muscular hypotonia (HP:0006829)	1.93545327
70	Genital tract atresia (HP:0001827)	1.93444930
71	Polyuria (HP:0000103)	1.92745943
72	Vaginal atresia (HP:0000148)	1.90404879
73	Agitation (HP:0000713)	1.89446579
74	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.89379863
75	Hyperglycinuria (HP:0003108)	1.89317192
76	Poor coordination (HP:0002370)	1.88834147
77	Limb dystonia (HP:0002451)	1.88312892
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.86628231
79	Optic disc pallor (HP:0000543)	1.86259047
80	Renal cortical cysts (HP:0000803)	1.86187698
81	Congenital sensorineural hearing impairment (HP:0008527)	1.85358269
82	Fair hair (HP:0002286)	1.85185321
83	Focal seizures (HP:0007359)	1.85062144
84	Partial agenesis of the corpus callosum (HP:0001338)	1.83760459
85	Chorioretinal atrophy (HP:0000533)	1.83021178
86	Hemiparesis (HP:0001269)	1.82157285
87	Tachypnea (HP:0002789)	1.81148010
88	Abnormal ciliary motility (HP:0012262)	1.80939922
89	Oligodactyly (hands) (HP:0001180)	1.79326826
90	Septo-optic dysplasia (HP:0100842)	1.78315984
91	3-Methylglutaconic aciduria (HP:0003535)	1.76999918
92	Acute necrotizing encephalopathy (HP:0006965)	1.76928817
93	Bilateral microphthalmos (HP:0007633)	1.74875963
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74854761
95	Pachygyria (HP:0001302)	1.74086241
96	Dialeptic seizures (HP:0011146)	1.73346342
97	Prominent supraorbital ridges (HP:0000336)	1.72719856
98	Hypoplastic ischia (HP:0003175)	1.69290237
99	Mitochondrial inheritance (HP:0001427)	1.68118826
100	Postaxial hand polydactyly (HP:0001162)	1.67042391

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.00986525
2	BMPR1B	3.53480552
3	ADRBK2	3.44983784
4	INSRR	3.42131056
5	ACVR1B	2.98891744
6	CASK	2.76750136
7	WNK4	2.59034213
8	GRK1	2.45234661
9	WNK3	2.44345857
10	ZAK	2.38133669
11	PNCK	2.30689186
12	TLK1	2.20606595
13	MAPK13	2.20594346
14	PINK1	2.16630156
15	MARK1	1.98059877
16	MAP3K4	1.76465528
17	TAOK3	1.75120222
18	MAP4K2	1.70621584
19	TNIK	1.66934230
20	DAPK2	1.52838311
21	OXSR1	1.51635172
22	TXK	1.50000159
23	TGFBR1	1.49868221
24	MAPK15	1.48497589
25	CAMKK2	1.41539021
26	NUAK1	1.40832517
27	ADRBK1	1.40780863
28	NTRK3	1.40235031
29	DYRK2	1.32817405
30	STK39	1.20024038
31	NTRK2	1.16969232
32	PRKCG	1.14573702
33	SIK2	1.07772990
34	MAP2K7	1.06641242
35	MKNK2	1.03181558
36	PAK3	1.02414579
37	PIK3CA	0.99707628
38	WEE1	0.92058890
39	TYRO3	0.87114705
40	NEK2	0.81284261
41	MUSK	0.80608826
42	PKN1	0.79831178
43	TIE1	0.78291844
44	PHKG1	0.77519625
45	PHKG2	0.77519625
46	PRKCE	0.77465509
47	PRKCQ	0.74251561
48	STK11	0.72597497
49	MAPKAPK5	0.67598165
50	CAMK2A	0.67503104
51	PTK2B	0.65969212
52	MAPKAPK3	0.65107166
53	CDK19	0.63507724
54	RPS6KA5	0.63233969
55	STK3	0.62935086
56	CAMK1	0.59122798
57	MAP2K6	0.55350860
58	CAMKK1	0.54723520
59	CHUK	0.53980391
60	PRKACA	0.53171836
61	RPS6KA6	0.51909792
62	VRK1	0.50144662
63	OBSCN	0.49417300
64	PRKCZ	0.46818399
65	CSNK1G2	0.44801905
66	TEC	0.44472234
67	CAMK1D	0.44410261
68	MAP2K1	0.43770191
69	LIMK1	0.43574139
70	NME1	0.42891263
71	DYRK1A	0.41680766
72	CAMK4	0.41515681
73	CHEK2	0.41037164
74	TRIM28	0.40988224
75	IKBKB	0.40545208
76	IRAK1	0.40146320
77	MAP2K4	0.39923645
78	CSNK1A1	0.38092471
79	PRKCA	0.37070117
80	BRSK2	0.36952984
81	PRKG1	0.35507416
82	PLK2	0.35285762
83	MAP3K9	0.34970577
84	WNK1	0.34839920
85	PLK4	0.34126227
86	PRKCH	0.34059022
87	MKNK1	0.33939392
88	GRK7	0.33482811
89	SGK2	0.33256449
90	CAMK1G	0.32866673
91	TAF1	0.32044136
92	STK38L	0.31919308
93	ERBB2	0.31916659
94	ITK	0.31647521
95	PRKAA2	0.31051522
96	BCKDK	0.30789148
97	BCR	0.30789065
98	CSNK1D	0.30359674
99	SGK494	0.30245811
100	SGK223	0.30245811

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.06126469
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.96066801
3	Nicotine addiction_Homo sapiens_hsa05033	2.87178516
4	Phototransduction_Homo sapiens_hsa04744	2.80610106
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.52646551
6	Butanoate metabolism_Homo sapiens_hsa00650	2.39397833
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36664755
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.28854470
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.25615147
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.24889859
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17740955
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08303742
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.08050781
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.91916177
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90572857
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.76589961
17	Olfactory transduction_Homo sapiens_hsa04740	1.71602728
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71576325
19	Parkinsons disease_Homo sapiens_hsa05012	1.68336144
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67626784
21	Taste transduction_Homo sapiens_hsa04742	1.67504620
22	Morphine addiction_Homo sapiens_hsa05032	1.65246498
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61512592
24	Homologous recombination_Homo sapiens_hsa03440	1.41525132
25	Caffeine metabolism_Homo sapiens_hsa00232	1.37793633
26	ABC transporters_Homo sapiens_hsa02010	1.31918181
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.30160024
28	RNA polymerase_Homo sapiens_hsa03020	1.29967309
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27526580
30	Circadian entrainment_Homo sapiens_hsa04713	1.24341078
31	GABAergic synapse_Homo sapiens_hsa04727	1.24249525
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23322214
33	Insulin secretion_Homo sapiens_hsa04911	1.23068320
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21993417
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21687122
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.20266080
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18935650
38	Alzheimers disease_Homo sapiens_hsa05010	1.17745994
39	Huntingtons disease_Homo sapiens_hsa05016	1.16960411
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16520314
41	Serotonergic synapse_Homo sapiens_hsa04726	1.15514104
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14803524
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13149424
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11315194
45	Protein export_Homo sapiens_hsa03060	1.09704784
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08812386
47	Basal transcription factors_Homo sapiens_hsa03022	1.08252269
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.05383950
49	Sulfur relay system_Homo sapiens_hsa04122	1.01001675
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99388369
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.97426801
52	Cocaine addiction_Homo sapiens_hsa05030	0.95611425
53	Ribosome_Homo sapiens_hsa03010	0.93865527
54	Peroxisome_Homo sapiens_hsa04146	0.92995646
55	Retinol metabolism_Homo sapiens_hsa00830	0.90407131
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.87041136
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83824430
58	Propanoate metabolism_Homo sapiens_hsa00640	0.80540119
59	RNA degradation_Homo sapiens_hsa03018	0.79472655
60	Histidine metabolism_Homo sapiens_hsa00340	0.79427539
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75532325
62	Salivary secretion_Homo sapiens_hsa04970	0.74752397
63	One carbon pool by folate_Homo sapiens_hsa00670	0.74733644
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.74002894
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73610496
66	Cholinergic synapse_Homo sapiens_hsa04725	0.72936694
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71491834
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71113042
69	Gastric acid secretion_Homo sapiens_hsa04971	0.67357978
70	Long-term depression_Homo sapiens_hsa04730	0.65744597
71	Amphetamine addiction_Homo sapiens_hsa05031	0.65292218
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63940796
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62901444
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60427746
75	Regulation of autophagy_Homo sapiens_hsa04140	0.60219246
76	Asthma_Homo sapiens_hsa05310	0.57517462
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.56022872
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55117973
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.55052651
80	Mineral absorption_Homo sapiens_hsa04978	0.53515704
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51436821
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51214169
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47740848
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47202534
85	Axon guidance_Homo sapiens_hsa04360	0.47146401
86	Metabolic pathways_Homo sapiens_hsa01100	0.46971944
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43417717
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41224875
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41139087
90	Sulfur metabolism_Homo sapiens_hsa00920	0.40875710
91	Purine metabolism_Homo sapiens_hsa00230	0.39915616
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.38405520
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36530833
94	Bile secretion_Homo sapiens_hsa04976	0.35050615
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.35006844
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.34860399
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33377224
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32063709
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30719577
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26677905

HERC2P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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