ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.40834337
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.78865132
3	L-fucose metabolic process (GO:0042354)	3.57330214
4	L-fucose catabolic process (GO:0042355)	3.57330214
5	fucose catabolic process (GO:0019317)	3.57330214
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50511512
7	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.43122022
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34187649
9	auditory behavior (GO:0031223)	3.31950855
10	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.27347193
11	regulation of translation, ncRNA-mediated (GO:0045974)	3.27347193
12	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.27347193
13	cilium or flagellum-dependent cell motility (GO:0001539)	3.27097710
14	behavioral response to ethanol (GO:0048149)	3.24172310
15	piRNA metabolic process (GO:0034587)	3.09447578
16	interkinetic nuclear migration (GO:0022027)	3.06957288
17	presynaptic membrane assembly (GO:0097105)	3.05576928
18	membrane depolarization during action potential (GO:0086010)	3.03174731
19	response to pheromone (GO:0019236)	3.02720367
20	neuronal action potential (GO:0019228)	3.00295869
21	dendritic spine morphogenesis (GO:0060997)	2.96237561
22	DNA methylation involved in gamete generation (GO:0043046)	2.95722276
23	mechanosensory behavior (GO:0007638)	2.93604943
24	neuronal action potential propagation (GO:0019227)	2.93412866
25	inner ear receptor stereocilium organization (GO:0060122)	2.92039817
26	gamma-aminobutyric acid transport (GO:0015812)	2.90304575
27	sulfation (GO:0051923)	2.88852678
28	cAMP catabolic process (GO:0006198)	2.86158331
29	vocalization behavior (GO:0071625)	2.85367268
30	presynaptic membrane organization (GO:0097090)	2.84672483
31	axon ensheathment in central nervous system (GO:0032291)	2.78789350
32	central nervous system myelination (GO:0022010)	2.78789350
33	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.78163477
34	protein localization to cilium (GO:0061512)	2.78138772
35	auditory receptor cell stereocilium organization (GO:0060088)	2.77231483
36	nephron tubule morphogenesis (GO:0072078)	2.77219725
37	nephron epithelium morphogenesis (GO:0072088)	2.77219725
38	detection of light stimulus involved in sensory perception (GO:0050962)	2.76831436
39	detection of light stimulus involved in visual perception (GO:0050908)	2.76831436
40	cyclic nucleotide catabolic process (GO:0009214)	2.74715492
41	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.72867132
42	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.68394126
43	pyrimidine nucleobase catabolic process (GO:0006208)	2.67407931
44	synaptic vesicle maturation (GO:0016188)	2.66880850
45	somite development (GO:0061053)	2.66593580
46	histone H3-K4 trimethylation (GO:0080182)	2.66140066
47	indolalkylamine metabolic process (GO:0006586)	2.66079291
48	indole-containing compound catabolic process (GO:0042436)	2.59462232
49	indolalkylamine catabolic process (GO:0046218)	2.59462232
50	tryptophan catabolic process (GO:0006569)	2.59462232
51	postsynaptic membrane organization (GO:0001941)	2.58902015
52	regulation of pigment cell differentiation (GO:0050932)	2.57736702
53	protein import into peroxisome matrix (GO:0016558)	2.56924310
54	retinal cone cell development (GO:0046549)	2.55780257
55	monoubiquitinated protein deubiquitination (GO:0035520)	2.55647076
56	photoreceptor cell maintenance (GO:0045494)	2.55283048
57	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.54853036
58	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.52873180
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52637812
60	nonmotile primary cilium assembly (GO:0035058)	2.50336818
61	glutamate receptor signaling pathway (GO:0007215)	2.49561332
62	rRNA catabolic process (GO:0016075)	2.48145734
63	renal tubule morphogenesis (GO:0061333)	2.47707707
64	epithelial cilium movement (GO:0003351)	2.47508398
65	action potential (GO:0001508)	2.47005033
66	positive regulation of developmental pigmentation (GO:0048087)	2.46754462
67	cilium organization (GO:0044782)	2.46664403
68	neurotransmitter catabolic process (GO:0042135)	2.46642820
69	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.46192407
70	negative regulation of neurotransmitter transport (GO:0051589)	2.45627853
71	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.44582306
72	kynurenine metabolic process (GO:0070189)	2.44418806
73	cilium morphogenesis (GO:0060271)	2.43564410
74	neural tube formation (GO:0001841)	2.43324653
75	serotonin metabolic process (GO:0042428)	2.41359848
76	atrial cardiac muscle cell action potential (GO:0086014)	2.40897195
77	cilium assembly (GO:0042384)	2.40750375
78	transmission of nerve impulse (GO:0019226)	2.39975497
79	neuron cell-cell adhesion (GO:0007158)	2.38858514
80	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.38793710
81	synaptic transmission, glutamatergic (GO:0035249)	2.38347599
82	startle response (GO:0001964)	2.37416193
83	reflex (GO:0060004)	2.34249594
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.34224065
85	spinal cord development (GO:0021510)	2.34012291
86	positive regulation of CREB transcription factor activity (GO:0032793)	2.33917881
87	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.33390656
88	intraciliary transport (GO:0042073)	2.33354058
89	spinal cord motor neuron differentiation (GO:0021522)	2.31962170
90	hindbrain development (GO:0030902)	2.31526148
91	cellular ketone body metabolic process (GO:0046950)	2.31263331
92	C4-dicarboxylate transport (GO:0015740)	2.31112602
93	neurotransmitter-gated ion channel clustering (GO:0072578)	2.30347005
94	primary amino compound metabolic process (GO:1901160)	2.29740728
95	proline transport (GO:0015824)	2.29716616
96	indole-containing compound metabolic process (GO:0042430)	2.29435432
97	establishment of protein localization to Golgi (GO:0072600)	2.28876313
98	protein localization to synapse (GO:0035418)	2.28195181
99	ketone body metabolic process (GO:1902224)	2.26969793
100	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.26123995

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.51352234
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.36879838
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.34766524
4	VDR_22108803_ChIP-Seq_LS180_Human	3.00291769
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92316539
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74923191
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70449503
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66143658
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58941259
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.41026703
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.36962697
12	FUS_26573619_Chip-Seq_HEK293_Human	2.21694847
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16833765
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.15348365
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14057873
16	EWS_26573619_Chip-Seq_HEK293_Human	2.01289413
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.97636898
18	P300_19829295_ChIP-Seq_ESCs_Human	1.93833147
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92559926
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80125825
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79366063
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.78924050
23	STAT3_23295773_ChIP-Seq_U87_Human	1.78411458
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72674640
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70092772
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69974977
27	TCF4_23295773_ChIP-Seq_U87_Human	1.65111800
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62024659
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59861675
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.57163237
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56318345
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54851276
33	AR_25329375_ChIP-Seq_VCAP_Human	1.54618471
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51120525
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51120525
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50533585
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49530099
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49530099
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48619844
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46885798
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45857590
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.45509105
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43595376
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43533949
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42975984
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40057825
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38529284
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.38267635
49	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.38142704
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36874105
51	DROSHA_22980978_ChIP-Seq_HELA_Human	1.35757238
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35426205
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32839160
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30208852
55	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.24972330
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24901100
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24672720
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.24216323
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22620695
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22318651
61	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21423887
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21233886
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20971262
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18701904
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17974422
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.17675117
67	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.17336275
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16049680
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15663573
70	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15266853
71	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.13897777
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13640379
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13366938
74	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12927257
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.11923760
76	TP53_16413492_ChIP-PET_HCT116_Human	1.11475114
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11451509
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11191758
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11147693
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10937278
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09260937
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08240811
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07951398
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07237559
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06604607
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06275491
87	RXR_22108803_ChIP-Seq_LS180_Human	1.05512705
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.04822247
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04588484
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.03123507
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02040649
92	KDM2B_26808549_Chip-Seq_REH_Human	1.01954062
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01049287
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00966917
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00629113
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00196606
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99355343
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99048326
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97506916
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97203801

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.08864615
2	MP0004147_increased_porphyrin_level	2.50802539
3	MP0005646_abnormal_pituitary_gland	2.44856971
4	MP0004885_abnormal_endolymph	2.42003213
5	MP0000569_abnormal_digit_pigmentation	2.34473787
6	MP0009745_abnormal_behavioral_response	2.33925095
7	MP0003787_abnormal_imprinting	2.24789160
8	MP0001486_abnormal_startle_reflex	2.23855541
9	MP0005551_abnormal_eye_electrophysiolog	2.15889793
10	MP0008877_abnormal_DNA_methylation	2.15669681
11	MP0009046_muscle_twitch	2.12826427
12	MP0002102_abnormal_ear_morphology	2.10902560
13	MP0002272_abnormal_nervous_system	2.06576343
14	MP0001986_abnormal_taste_sensitivity	2.05625367
15	MP0001968_abnormal_touch/_nociception	2.02116265
16	MP0004859_abnormal_synaptic_plasticity	2.01946675
17	MP0003635_abnormal_synaptic_transmissio	1.99512860
18	MP0004145_abnormal_muscle_electrophysio	1.97703306
19	MP0002638_abnormal_pupillary_reflex	1.97055835
20	MP0002064_seizures	1.96158811
21	MP0001501_abnormal_sleep_pattern	1.95684324
22	MP0006276_abnormal_autonomic_nervous	1.91896229
23	MP0003195_calcinosis	1.90199842
24	MP0004043_abnormal_pH_regulation	1.89214199
25	MP0002572_abnormal_emotion/affect_behav	1.88391860
26	MP0002735_abnormal_chemical_nociception	1.74922652
27	MP0005423_abnormal_somatic_nervous	1.74848388
28	MP0002063_abnormal_learning/memory/cond	1.73689744
29	MP0000631_abnormal_neuroendocrine_gland	1.69580497
30	MP0006072_abnormal_retinal_apoptosis	1.66242189
31	MP0006292_abnormal_olfactory_placode	1.62258740
32	MP0000778_abnormal_nervous_system	1.61261269
33	MP0004133_heterotaxia	1.55624999
34	MP0001970_abnormal_pain_threshold	1.52571142
35	MP0008775_abnormal_heart_ventricle	1.50381957
36	MP0005187_abnormal_penis_morphology	1.47583016
37	MP0002557_abnormal_social/conspecific_i	1.47550444
38	MP0005253_abnormal_eye_physiology	1.46617144
39	MP0005386_behavior/neurological_phenoty	1.45770682
40	MP0004924_abnormal_behavior	1.45770682
41	MP0000372_irregular_coat_pigmentation	1.44085017
42	MP0004215_abnormal_myocardial_fiber	1.42592993
43	MP0002734_abnormal_mechanical_nocicepti	1.42558093
44	MP0001984_abnormal_olfaction	1.42208785
45	MP0001485_abnormal_pinna_reflex	1.41334120
46	MP0002736_abnormal_nociception_after	1.41296747
47	MP0008995_early_reproductive_senescence	1.39921924
48	MP0000427_abnormal_hair_cycle	1.34507826
49	MP0000383_abnormal_hair_follicle	1.32663473
50	MP0002733_abnormal_thermal_nociception	1.32218318
51	MP0005167_abnormal_blood-brain_barrier	1.31996021
52	MP0004270_analgesia	1.31026973
53	MP0002009_preneoplasia	1.29048424
54	MP0001502_abnormal_circadian_rhythm	1.27885395
55	MP0001440_abnormal_grooming_behavior	1.26000795
56	MP0002067_abnormal_sensory_capabilities	1.25168327
57	MP0002822_catalepsy	1.22701382
58	MP0002837_dystrophic_cardiac_calcinosis	1.18266491
59	MP0002928_abnormal_bile_duct	1.17729843
60	MP0003121_genomic_imprinting	1.16330778
61	MP0010386_abnormal_urinary_bladder	1.15882812
62	MP0002938_white_spotting	1.13481012
63	MP0005645_abnormal_hypothalamus_physiol	1.13325051
64	MP0004142_abnormal_muscle_tone	1.12065967
65	MP0003646_muscle_fatigue	1.10195243
66	MP0003137_abnormal_impulse_conducting	1.09380078
67	MP0004085_abnormal_heartbeat	1.09160297
68	MP0003136_yellow_coat_color	1.08978293
69	MP0008872_abnormal_physiological_respon	1.06543577
70	MP0002138_abnormal_hepatobiliary_system	1.05999963
71	MP0004742_abnormal_vestibular_system	1.03362292
72	MP0002882_abnormal_neuron_morphology	1.02794213
73	MP0002184_abnormal_innervation	1.00488461
74	MP0001188_hyperpigmentation	0.99029725
75	MP0002229_neurodegeneration	0.98362794
76	MP0002876_abnormal_thyroid_physiology	0.95034217
77	MP0003890_abnormal_embryonic-extraembry	0.94951381
78	MP0000955_abnormal_spinal_cord	0.94783687
79	MP0004130_abnormal_muscle_cell	0.93495751
80	MP0002752_abnormal_somatic_nervous	0.93473814
81	MP0005171_absent_coat_pigmentation	0.92953611
82	MP0000230_abnormal_systemic_arterial	0.92214533
83	MP0005174_abnormal_tail_pigmentation	0.91425699
84	MP0004484_altered_response_of	0.88850268
85	MP0000516_abnormal_urinary_system	0.86702022
86	MP0005367_renal/urinary_system_phenotyp	0.86702022
87	MP0010368_abnormal_lymphatic_system	0.86388874
88	MP0001963_abnormal_hearing_physiology	0.86226647
89	MP0003698_abnormal_male_reproductive	0.84869393
90	MP0003633_abnormal_nervous_system	0.84225892
91	MP0000026_abnormal_inner_ear	0.83486693
92	MP0001879_abnormal_lymphatic_vessel	0.82421214
93	MP0003283_abnormal_digestive_organ	0.81783912
94	MP0002234_abnormal_pharynx_morphology	0.81133172
95	MP0002066_abnormal_motor_capabilities/c	0.77366078
96	MP0002152_abnormal_brain_morphology	0.77257893
97	MP0005195_abnormal_posterior_eye	0.76419618
98	MP0000538_abnormal_urinary_bladder	0.75731674
99	MP0003119_abnormal_digestive_system	0.72981223
100	MP0004084_abnormal_cardiac_muscle	0.72377031

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.94104545
2	Nephronophthisis (HP:0000090)	3.89033765
3	Pancreatic cysts (HP:0001737)	3.68045332
4	Abnormality of the renal medulla (HP:0100957)	3.50418744
5	Febrile seizures (HP:0002373)	3.45864399
6	Pancreatic fibrosis (HP:0100732)	3.39939075
7	Genetic anticipation (HP:0003743)	3.32661835
8	True hermaphroditism (HP:0010459)	3.23626469
9	Abnormality of midbrain morphology (HP:0002418)	3.20567123
10	Molar tooth sign on MRI (HP:0002419)	3.20567123
11	Medial flaring of the eyebrow (HP:0010747)	3.19413574
12	Progressive cerebellar ataxia (HP:0002073)	3.17314756
13	Hemiparesis (HP:0001269)	3.12372700
14	Focal seizures (HP:0007359)	3.10899070
15	Broad-based gait (HP:0002136)	3.10363988
16	Abnormality of the renal cortex (HP:0011035)	3.06974838
17	Type II lissencephaly (HP:0007260)	3.05113825
18	Focal motor seizures (HP:0011153)	3.03137531
19	Gaze-evoked nystagmus (HP:0000640)	3.00136258
20	Congenital stationary night blindness (HP:0007642)	2.94153206
21	Atonic seizures (HP:0010819)	2.89697660
22	Abnormal drinking behavior (HP:0030082)	2.83689790
23	Polydipsia (HP:0001959)	2.83689790
24	Protruding tongue (HP:0010808)	2.83448775
25	Gait imbalance (HP:0002141)	2.74453037
26	Cerebellar dysplasia (HP:0007033)	2.68384189
27	Cystic liver disease (HP:0006706)	2.65369382
28	Drooling (HP:0002307)	2.64783937
29	Dialeptic seizures (HP:0011146)	2.57407265
30	Decreased circulating renin level (HP:0003351)	2.57184992
31	Congenital primary aphakia (HP:0007707)	2.47358612
32	Attenuation of retinal blood vessels (HP:0007843)	2.44487205
33	Widely spaced teeth (HP:0000687)	2.42152903
34	Tubular atrophy (HP:0000092)	2.40989756
35	Hypothermia (HP:0002045)	2.40191544
36	Congenital hepatic fibrosis (HP:0002612)	2.38639057
37	Abolished electroretinogram (ERG) (HP:0000550)	2.35259664
38	Large for gestational age (HP:0001520)	2.34718507
39	Chronic hepatic failure (HP:0100626)	2.34101711
40	Excessive salivation (HP:0003781)	2.33648276
41	Clumsiness (HP:0002312)	2.26274088
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.22105174
43	Nephrogenic diabetes insipidus (HP:0009806)	2.21983690
44	Keratoconus (HP:0000563)	2.21398996
45	Increased corneal curvature (HP:0100692)	2.21398996
46	Epileptic encephalopathy (HP:0200134)	2.19140311
47	Dyskinesia (HP:0100660)	2.17566959
48	Absence seizures (HP:0002121)	2.13542845
49	Genital tract atresia (HP:0001827)	2.11774393
50	Diplopia (HP:0000651)	2.11310629
51	Abnormality of binocular vision (HP:0011514)	2.11310629
52	Absent speech (HP:0001344)	2.08269747
53	Vaginal atresia (HP:0000148)	2.07727781
54	Polyuria (HP:0000103)	2.06607881
55	Prolonged QT interval (HP:0001657)	2.04620982
56	Decreased central vision (HP:0007663)	2.03456106
57	Poor coordination (HP:0002370)	2.03076988
58	Abnormality of the renal collecting system (HP:0004742)	2.00220991
59	Inability to walk (HP:0002540)	1.98934566
60	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.96491026
61	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.96491026
62	Hypoplastic iliac wings (HP:0002866)	1.95923500
63	Stomach cancer (HP:0012126)	1.95307990
64	Duplicated collecting system (HP:0000081)	1.93555380
65	Abnormality of the ischium (HP:0003174)	1.92854323
66	Renal cortical cysts (HP:0000803)	1.91625307
67	Volvulus (HP:0002580)	1.91192437
68	Tubulointerstitial nephritis (HP:0001970)	1.91102076
69	Concave nail (HP:0001598)	1.89913701
70	Anterior segment dysgenesis (HP:0007700)	1.89325982
71	Pachygyria (HP:0001302)	1.88834939
72	Lissencephaly (HP:0001339)	1.86337979
73	Abnormal biliary tract physiology (HP:0012439)	1.86079805
74	Bile duct proliferation (HP:0001408)	1.86079805
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.85802443
76	Absent/shortened dynein arms (HP:0200106)	1.85802443
77	Fair hair (HP:0002286)	1.83679621
78	Short foot (HP:0001773)	1.82283021
79	Tachypnea (HP:0002789)	1.80290422
80	Hypoplastic ischia (HP:0003175)	1.79343364
81	Specific learning disability (HP:0001328)	1.76128650
82	Generalized tonic-clonic seizures (HP:0002069)	1.75386169
83	Neoplasm of the adrenal cortex (HP:0100641)	1.74570005
84	Chorioretinal atrophy (HP:0000533)	1.74154397
85	Progressive inability to walk (HP:0002505)	1.74096171
86	Blue irides (HP:0000635)	1.73985765
87	Patellar aplasia (HP:0006443)	1.73492428
88	Polyphagia (HP:0002591)	1.73110284
89	Urinary bladder sphincter dysfunction (HP:0002839)	1.72420236
90	Aqueductal stenosis (HP:0002410)	1.68900749
91	Abnormality of renin-angiotensin system (HP:0000847)	1.68262222
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.66341111
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.66341111
94	Highly arched eyebrow (HP:0002553)	1.65323266
95	Small hand (HP:0200055)	1.64249524
96	Dysdiadochokinesis (HP:0002075)	1.63387697
97	Postaxial foot polydactyly (HP:0001830)	1.63068410
98	Thyroid-stimulating hormone excess (HP:0002925)	1.63021106
99	Postaxial hand polydactyly (HP:0001162)	1.62668641
100	Furrowed tongue (HP:0000221)	1.61891853

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.99730760
2	MAP4K2	2.81239911
3	PINK1	2.56413890
4	ACVR1B	2.53060929
5	BMPR1B	2.35747263
6	CASK	2.20482290
7	MAPK13	2.19795359
8	MARK1	2.16598993
9	NTRK3	2.16288555
10	FGFR2	2.05139640
11	PNCK	2.00635573
12	MAP3K4	1.96013054
13	WNK3	1.86913248
14	WNK4	1.82748229
15	ADRBK2	1.69190875
16	OXSR1	1.68644719
17	STK39	1.58169605
18	NUAK1	1.55499126
19	MKNK2	1.54519665
20	GRK1	1.53522398
21	EPHA4	1.53475127
22	TNIK	1.45568544
23	TAOK3	1.45352287
24	DAPK2	1.43784262
25	AKT3	1.42978418
26	TIE1	1.36433050
27	MAPK15	1.31651960
28	INSRR	1.25436982
29	PIK3CA	1.24828868
30	PHKG1	1.24263073
31	PHKG2	1.24263073
32	TEC	1.22379961
33	NTRK2	1.21643395
34	CAMK1G	1.19098378
35	TLK1	1.12503452
36	CAMK1D	1.09988496
37	PAK3	1.06688305
38	CAMKK2	1.05254176
39	PRKD3	1.03999273
40	MKNK1	1.03576643
41	MAPKAPK3	1.03021862
42	ERBB3	0.91821811
43	PLK2	0.90740400
44	CDK3	0.83905574
45	SGK2	0.83411031
46	MINK1	0.82934670
47	WNK1	0.80736350
48	PRKCE	0.80721757
49	MAP2K6	0.80481536
50	EPHA3	0.77671284
51	ZAK	0.77629673
52	CAMK1	0.77100637
53	TRPM7	0.76633042
54	MAPKAPK5	0.76342414
55	STK11	0.76213649
56	TGFBR1	0.75000448
57	BRD4	0.74888604
58	EPHB2	0.73551920
59	ITK	0.73428498
60	PTK2B	0.70216731
61	OBSCN	0.70152598
62	MAP2K4	0.69972066
63	KIT	0.67401422
64	SIK2	0.64496651
65	DYRK1A	0.62863026
66	PRKCG	0.61574250
67	ADRBK1	0.61414588
68	NLK	0.59474694
69	CAMK2A	0.59025500
70	DYRK2	0.58994951
71	MAP3K7	0.58471608
72	PRKAA2	0.58268925
73	SGK494	0.57666283
74	SGK223	0.57666283
75	SGK1	0.56650192
76	BRSK2	0.56624951
77	WEE1	0.55920748
78	PRKAA1	0.50288136
79	TYRO3	0.48864608
80	CAMKK1	0.47781316
81	PRKG1	0.47295155
82	ERBB2	0.47221883
83	IRAK1	0.46493977
84	UHMK1	0.45557981
85	CSNK1G2	0.45312446
86	FLT3	0.45282623
87	MAP2K7	0.44744383
88	PRKCH	0.44527631
89	TRIM28	0.44421332
90	CDK5	0.41389228
91	FER	0.41071782
92	PRKACA	0.40574256
93	CAMK4	0.39904544
94	RPS6KA3	0.37805255
95	STK38L	0.37028231
96	CSNK1G1	0.36020248
97	CSNK1A1L	0.35906295
98	PAK6	0.35759003
99	RPS6KA5	0.35549084
100	PKN1	0.34688221

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.26223947
2	Phototransduction_Homo sapiens_hsa04744	2.75127096
3	Circadian entrainment_Homo sapiens_hsa04713	2.27551415
4	Morphine addiction_Homo sapiens_hsa05032	2.16858124
5	Glutamatergic synapse_Homo sapiens_hsa04724	2.15077681
6	Insulin secretion_Homo sapiens_hsa04911	2.14234199
7	Taste transduction_Homo sapiens_hsa04742	2.12492484
8	Butanoate metabolism_Homo sapiens_hsa00650	2.08927510
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.07907255
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.06792431
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03735389
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.01336702
13	GABAergic synapse_Homo sapiens_hsa04727	1.99117648
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88837961
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78080236
16	Salivary secretion_Homo sapiens_hsa04970	1.71953539
17	ABC transporters_Homo sapiens_hsa02010	1.71378206
18	Amphetamine addiction_Homo sapiens_hsa05031	1.65194874
19	Regulation of autophagy_Homo sapiens_hsa04140	1.62049936
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59792903
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58950384
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.58605509
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55486085
24	Olfactory transduction_Homo sapiens_hsa04740	1.53840153
25	Serotonergic synapse_Homo sapiens_hsa04726	1.51943639
26	Dopaminergic synapse_Homo sapiens_hsa04728	1.49085984
27	Cocaine addiction_Homo sapiens_hsa05030	1.48442270
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.47512251
29	Renin secretion_Homo sapiens_hsa04924	1.47390971
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.42496311
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.41126381
32	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.38736164
33	Propanoate metabolism_Homo sapiens_hsa00640	1.37909160
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34726907
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.31476382
36	Cholinergic synapse_Homo sapiens_hsa04725	1.31396754
37	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.29953238
38	Long-term depression_Homo sapiens_hsa04730	1.28904753
39	Gastric acid secretion_Homo sapiens_hsa04971	1.27989332
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25271041
41	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.20519749
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14544008
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.10750958
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09952825
45	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.09863748
46	Circadian rhythm_Homo sapiens_hsa04710	1.03244581
47	Lysine degradation_Homo sapiens_hsa00310	0.98116617
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95594554
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.94523278
50	Caffeine metabolism_Homo sapiens_hsa00232	0.92682476
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.87882676
52	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.87550421
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87180433
54	Basal transcription factors_Homo sapiens_hsa03022	0.85047936
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82141909
56	Bile secretion_Homo sapiens_hsa04976	0.82117229
57	Homologous recombination_Homo sapiens_hsa03440	0.79016653
58	Pancreatic secretion_Homo sapiens_hsa04972	0.75501937
59	Peroxisome_Homo sapiens_hsa04146	0.75286845
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72226392
61	Long-term potentiation_Homo sapiens_hsa04720	0.66056548
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64916770
63	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63130191
64	RNA degradation_Homo sapiens_hsa03018	0.62606405
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61705657
66	Type II diabetes mellitus_Homo sapiens_hsa04930	0.60076220
67	Histidine metabolism_Homo sapiens_hsa00340	0.59369164
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59334976
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59178797
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.59161403
71	Axon guidance_Homo sapiens_hsa04360	0.58925992
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.57956004
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56476106
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56434124
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55924653
76	Estrogen signaling pathway_Homo sapiens_hsa04915	0.54350252
77	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53377232
78	GnRH signaling pathway_Homo sapiens_hsa04912	0.52574430
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51513434
80	Asthma_Homo sapiens_hsa05310	0.51211526
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51198402
82	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51015428
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49455503
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.46965556
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.46934004
86	Oocyte meiosis_Homo sapiens_hsa04114	0.46771021
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46291156
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.45832981
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43088286
90	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42986658
91	Protein export_Homo sapiens_hsa03060	0.42267191
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41930352
93	Ras signaling pathway_Homo sapiens_hsa04014	0.41880290
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41701235
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40384391
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40018197
97	Melanogenesis_Homo sapiens_hsa04916	0.39240478
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38341995
99	Platelet activation_Homo sapiens_hsa04611	0.37383533
100	Retinol metabolism_Homo sapiens_hsa00830	0.37122414

HERC2P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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