HERC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pericardium development (GO:0060039)5.31402663
2UDP-N-acetylglucosamine metabolic process (GO:0006047)5.26308584
3cellular response to ATP (GO:0071318)4.88400542
4regulation of hippo signaling (GO:0035330)4.65107590
5nuclear pore complex assembly (GO:0051292)4.18314174
6nuclear pore organization (GO:0006999)4.16885336
7protein K48-linked deubiquitination (GO:0071108)4.01650063
8glomerular visceral epithelial cell development (GO:0072015)3.97538487
9protein K63-linked deubiquitination (GO:0070536)3.94971686
10endocardial cushion development (GO:0003197)3.87809006
11interkinetic nuclear migration (GO:0022027)3.77400756
12regulation of establishment of cell polarity (GO:2000114)3.74370879
13establishment of protein localization to Golgi (GO:0072600)3.60688700
14replicative senescence (GO:0090399)3.56980537
15protein K11-linked deubiquitination (GO:0035871)3.53224110
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.47739949
17response to pheromone (GO:0019236)3.45878927
18neural tube formation (GO:0001841)3.43654854
19glycine metabolic process (GO:0006544)3.43296522
20histone-serine phosphorylation (GO:0035404)3.38262312
21L-fucose catabolic process (GO:0042355)3.34791132
22fucose catabolic process (GO:0019317)3.34791132
23L-fucose metabolic process (GO:0042354)3.34791132
24negative regulation of mast cell activation (GO:0033004)3.34143881
25snRNA transcription (GO:0009301)3.33268533
26folic acid-containing compound biosynthetic process (GO:0009396)3.30833674
27sequestering of extracellular ligand from receptor (GO:0035581)3.28983416
28protein prenylation (GO:0018342)3.24715830
29prenylation (GO:0097354)3.24715830
30glomerular epithelial cell development (GO:0072310)3.23924973
31negative regulation of axon guidance (GO:1902668)3.22842772
32pore complex assembly (GO:0046931)3.18199415
33regulation of pigment cell differentiation (GO:0050932)3.15759618
34regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.15374104
35phospholipid translocation (GO:0045332)3.15220515
36lipid translocation (GO:0034204)3.15220515
37rRNA catabolic process (GO:0016075)3.13978683
38protein localization to kinetochore (GO:0034501)3.13437131
39regulation of mesoderm development (GO:2000380)3.12232276
40cytoplasmic mRNA processing body assembly (GO:0033962)3.08621397
41cellular response to ethanol (GO:0071361)3.06901493
42mitotic nuclear envelope disassembly (GO:0007077)3.05272733
43urea cycle (GO:0000050)3.04915995
44urea metabolic process (GO:0019627)3.04915995
45lymphangiogenesis (GO:0001946)3.04784113
46serine family amino acid catabolic process (GO:0009071)3.01538270
47regulation of establishment or maintenance of cell polarity (GO:0032878)3.00654550
48cysteine metabolic process (GO:0006534)2.99777224
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98687187
50positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.98255985
51regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.98255985
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96545991
53endosome to pigment granule transport (GO:0043485)2.94061203
54endosome to melanosome transport (GO:0035646)2.94061203
55dermatan sulfate biosynthetic process (GO:0030208)2.92192728
56membrane disassembly (GO:0030397)2.92108806
57nuclear envelope disassembly (GO:0051081)2.92108806
58smooth muscle tissue development (GO:0048745)2.91967265
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90788101
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.90788101
61regulation of translation, ncRNA-mediated (GO:0045974)2.90788101
62folic acid metabolic process (GO:0046655)2.90049775
63regulation of histone H3-K9 methylation (GO:0051570)2.89114104
64purine nucleobase biosynthetic process (GO:0009113)2.88170458
65positive regulation of developmental pigmentation (GO:0048087)2.87541359
66IMP biosynthetic process (GO:0006188)2.85937041
67protein localization to chromosome, centromeric region (GO:0071459)2.84537538
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.83450177
69L-phenylalanine catabolic process (GO:0006559)2.83450177
70protein targeting to Golgi (GO:0000042)2.83144888
71L-phenylalanine metabolic process (GO:0006558)2.83078813
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83078813
73serine family amino acid metabolic process (GO:0009069)2.82857491
74anterior/posterior axis specification, embryo (GO:0008595)2.82656120
75nucleobase biosynthetic process (GO:0046112)2.81629880
76positive regulation of mitotic sister chromatid separation (GO:1901970)2.81626910
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81626910
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81626910
79mesenchymal-epithelial cell signaling (GO:0060638)2.80965017
80negative regulation of nitric-oxide synthase activity (GO:0051001)2.80862649
81chaperone-mediated protein complex assembly (GO:0051131)2.79692336
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77796124
83nucleotide-sugar metabolic process (GO:0009225)2.77348624
84neural crest cell development (GO:0014032)2.77332075
85tetrahydrofolate metabolic process (GO:0046653)2.76943449
86aromatic amino acid family catabolic process (GO:0009074)2.76650330
87complement activation, alternative pathway (GO:0006957)2.76646144
88regulation of protein activation cascade (GO:2000257)2.76618085
89homocysteine metabolic process (GO:0050667)2.73658853
90indolalkylamine catabolic process (GO:0046218)2.71289356
91tryptophan catabolic process (GO:0006569)2.71289356
92indole-containing compound catabolic process (GO:0042436)2.71289356
93import into cell (GO:0098657)2.71167123
94serine family amino acid biosynthetic process (GO:0009070)2.70964834
95fibroblast migration (GO:0010761)2.69317924
96negative regulation of fatty acid biosynthetic process (GO:0045717)2.69077495
97regulation of MHC class I biosynthetic process (GO:0045343)2.68965671
98dosage compensation (GO:0007549)2.68805996
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.67815652
100amino-acid betaine metabolic process (GO:0006577)2.67678523
101nitrogen cycle metabolic process (GO:0071941)2.67548502
102DNA replication-dependent nucleosome assembly (GO:0006335)2.66483459
103DNA replication-dependent nucleosome organization (GO:0034723)2.66483459
104iron ion import (GO:0097286)2.65959337
105cellular ketone body metabolic process (GO:0046950)2.65840784
106kynurenine metabolic process (GO:0070189)2.65470245
107regulation of complement activation (GO:0030449)2.64994786
108alpha-linolenic acid metabolic process (GO:0036109)2.64458771
109mitotic chromosome condensation (GO:0007076)2.64223614
110IMP metabolic process (GO:0046040)2.63904003
111mitotic sister chromatid cohesion (GO:0007064)2.62746300
112artery development (GO:0060840)2.62426037
113positive regulation of chromosome segregation (GO:0051984)2.62356789
114retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62235252
115cell adhesion mediated by integrin (GO:0033627)2.61924206
116protein targeting to lysosome (GO:0006622)2.61578859
117establishment of protein localization to vacuole (GO:0072666)2.61578859
118protein targeting to vacuole (GO:0006623)2.61578859
119nodal signaling pathway (GO:0038092)2.61518460
120glyoxylate metabolic process (GO:0046487)2.61477562
121negative regulation of fibrinolysis (GO:0051918)2.60878859
122tryptophan metabolic process (GO:0006568)2.60491507
123DNA unwinding involved in DNA replication (GO:0006268)2.59853260
124protein carboxylation (GO:0018214)2.59458780
125peptidyl-glutamic acid carboxylation (GO:0017187)2.59458780
126collagen fibril organization (GO:0030199)2.58291356
127protein localization to Golgi apparatus (GO:0034067)2.58247348
128histone mRNA catabolic process (GO:0071044)2.58215168
129activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.58175059
130regulation of spindle organization (GO:0090224)2.58111518
131negative regulation of histone methylation (GO:0031061)2.57980397
132regulation of posttranscriptional gene silencing (GO:0060147)2.57007090
133regulation of gene silencing by miRNA (GO:0060964)2.57007090
134regulation of gene silencing by RNA (GO:0060966)2.57007090
135negative regulation of keratinocyte proliferation (GO:0010839)2.55779003
136regulation of translational fidelity (GO:0006450)2.55485228
137indolalkylamine metabolic process (GO:0006586)2.55319653
138bile acid biosynthetic process (GO:0006699)2.55012830
139behavioral response to nicotine (GO:0035095)2.54110150
140regulation of fibroblast migration (GO:0010762)2.52799878
141sulfur amino acid catabolic process (GO:0000098)2.52659647
142cyclic nucleotide catabolic process (GO:0009214)2.50518123
143valine metabolic process (GO:0006573)2.50229455
144positive regulation of cardiac muscle cell differentiation (GO:2000727)2.47357778
145DNA geometric change (GO:0032392)2.47108550
146negative regulation of leukocyte chemotaxis (GO:0002689)2.46419558
147DNA duplex unwinding (GO:0032508)2.46110949
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44575677
149antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44575677
150cAMP catabolic process (GO:0006198)2.44267075
151ventricular septum development (GO:0003281)2.43876268
152negative regulation of systemic arterial blood pressure (GO:0003085)2.43651118
153embryonic forelimb morphogenesis (GO:0035115)2.43521567
154cellular response to vitamin D (GO:0071305)2.43240606
155dermatan sulfate metabolic process (GO:0030205)2.42126813
156endoderm formation (GO:0001706)2.42049551
157inner ear receptor cell development (GO:0060119)2.41812064
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41637304
159folic acid-containing compound metabolic process (GO:0006760)2.40630567
160phospholipid homeostasis (GO:0055091)2.40622313
161cornea development in camera-type eye (GO:0061303)2.40536113
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40460148
163regulation of interleukin-8 secretion (GO:2000482)2.40432176
164imidazole-containing compound metabolic process (GO:0052803)2.39266826
165negative regulation of complement activation (GO:0045916)2.38344989
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38116815
167mitotic metaphase plate congression (GO:0007080)2.37360943
168negative regulation of Rho protein signal transduction (GO:0035024)2.37309011
169negative regulation of sterol transport (GO:0032372)2.36961965
170negative regulation of cholesterol transport (GO:0032375)2.36961965
171lysine catabolic process (GO:0006554)2.36829295
172lysine metabolic process (GO:0006553)2.36829295
173antigen processing and presentation of endogenous antigen (GO:0019883)2.34770000
174negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.34099681
175determination of adult lifespan (GO:0008340)2.33821067
176oxidative demethylation (GO:0070989)2.33096335
177regulation of RNA export from nucleus (GO:0046831)2.32961720
178regulation of helicase activity (GO:0051095)2.31623431
179regulation of translational termination (GO:0006449)2.29467277
180nuclear envelope organization (GO:0006998)2.28658628
181monoubiquitinated protein deubiquitination (GO:0035520)2.27314095
182interferon-gamma secretion (GO:0072643)2.26927828
183heterochromatin organization (GO:0070828)2.26019290
184regulation of cholesterol homeostasis (GO:2000188)2.25513983
185regulation of mitotic spindle organization (GO:0060236)2.25218257
186positive regulation of SMAD protein import into nucleus (GO:0060391)2.23842206
187somatic hypermutation of immunoglobulin genes (GO:0016446)2.22202574
188somatic diversification of immune receptors via somatic mutation (GO:0002566)2.22202574
189DNA replication initiation (GO:0006270)2.21769523
190bile acid metabolic process (GO:0008206)2.21526184
191regulation of fibrinolysis (GO:0051917)2.21340894
192high-density lipoprotein particle remodeling (GO:0034375)2.20059080
193ethanol oxidation (GO:0006069)2.19763106
194phospholipid efflux (GO:0033700)2.18770206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64168266
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62126571
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.56016778
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.46750060
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.19193643
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88858833
7GBX2_23144817_ChIP-Seq_PC3_Human2.82618720
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72797011
9ZNF274_21170338_ChIP-Seq_K562_Hela2.61801557
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60020625
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52499093
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.50746342
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.41024461
14TP53_16413492_ChIP-PET_HCT116_Human2.36724303
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.31114822
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.29979421
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25990754
18EWS_26573619_Chip-Seq_HEK293_Human2.21839970
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.20812363
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20661688
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.18134178
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14706201
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.14433755
24FUS_26573619_Chip-Seq_HEK293_Human2.10931262
25P300_19829295_ChIP-Seq_ESCs_Human2.02152748
26CJUN_26792858_Chip-Seq_BT549_Human1.98664486
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97135834
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96218827
29TAF15_26573619_Chip-Seq_HEK293_Human1.94634319
30BRD4_25478319_ChIP-Seq_HGPS_Human1.93581550
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.93467336
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93122845
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.92024396
34VDR_22108803_ChIP-Seq_LS180_Human1.91601555
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88867103
36STAT3_23295773_ChIP-Seq_U87_Human1.86826580
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85083604
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84789516
39AR_21909140_ChIP-Seq_LNCAP_Human1.84666444
40MYC_22102868_ChIP-Seq_BL_Human1.84322478
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83790578
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82167981
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80186183
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80186183
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78789661
46ER_23166858_ChIP-Seq_MCF-7_Human1.76747632
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76666971
48SMAD4_21799915_ChIP-Seq_A2780_Human1.73472924
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72423359
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72269146
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71794407
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71393268
53GATA1_22025678_ChIP-Seq_K562_Human1.70798926
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66012308
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64691098
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64063657
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62616046
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.58370777
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58085483
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58048436
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57262789
62* EZH2_27294783_Chip-Seq_NPCs_Mouse1.55268249
63* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54033186
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53818895
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53657123
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51474388
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50670819
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49854298
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49816806
70TP53_18474530_ChIP-ChIP_U2OS_Human1.49040272
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48154909
72AHR_22903824_ChIP-Seq_MCF-7_Human1.47871257
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.47372369
74* TCF4_23295773_ChIP-Seq_U87_Human1.46933281
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45851827
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44401549
77CBP_20019798_ChIP-Seq_JUKART_Human1.44401549
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.43820785
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42286236
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42167434
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42037165
82BCAT_22108803_ChIP-Seq_LS180_Human1.41964107
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41743417
84CLOCK_20551151_ChIP-Seq_293T_Human1.41575912
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.39947401
86* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39275060
87* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38547318
88IGF1R_20145208_ChIP-Seq_DFB_Human1.38213889
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38136275
90AR_25329375_ChIP-Seq_VCAP_Human1.37394829
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36157987
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34671966
93* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34193133
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.34014867
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.32164592
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30411698
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29903180
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.28090306
99* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27403074
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.27078170
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26423305
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26090388
103MYB_26560356_Chip-Seq_TH1_Human1.25533658
104* CRX_20693478_ChIP-Seq_RETINA_Mouse1.25267971
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25205786
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25048325
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24923811
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24450938
109* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24343707
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23357192
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22925857
112CDX2_22108803_ChIP-Seq_LS180_Human1.22575897
113P53_22387025_ChIP-Seq_ESCs_Mouse1.21370839
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20782464
115* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20698035
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20104450
117MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19984228
118TCF4_22108803_ChIP-Seq_LS180_Human1.19293180
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18927094
120KDM5A_27292631_Chip-Seq_BREAST_Human1.18024776
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17038031
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16760318
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.15138006
124* KDM2B_26808549_Chip-Seq_REH_Human1.14179881
125AR_21572438_ChIP-Seq_LNCaP_Human1.12342280
126MYB_26560356_Chip-Seq_TH2_Human1.11764654
127* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11430116
128TP63_23658742_ChIP-Seq_EP156T_Human1.11259512
129RUNX2_22187159_ChIP-Seq_PCA_Human1.10770326
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10448416
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10448416
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10448416
133VDR_23849224_ChIP-Seq_CD4+_Human1.10281867
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10046724
135IRF8_27001747_Chip-Seq_BMDM_Mouse1.09985523
136MAF_26560356_Chip-Seq_TH1_Human1.09415039
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08606550
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08511768
139CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08436233
140* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07584647
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.07169414
142* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06946072
143* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06771334
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05993554
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05475771
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05225140
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05063411
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04803669
149TP63_17297297_ChIP-ChIP_HaCaT_Human1.04566878
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04442737
151XRN2_22483619_ChIP-Seq_HELA_Human1.04404919
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04130362
153RXR_22108803_ChIP-Seq_LS180_Human1.03399171
154NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02417902
155TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02289126
156SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02042346
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01863001
158CMYC_18555785_Chip-Seq_ESCs_Mouse1.01638655
159SPI1_23547873_ChIP-Seq_NB4_Human1.01113763
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00878739
161ZNF263_19887448_ChIP-Seq_K562_Human1.00678970
162NOTCH1_21737748_ChIP-Seq_TLL_Human1.00643432
163E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00560577
164HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00324242
165* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00110368
166STAT3_18555785_Chip-Seq_ESCs_Mouse0.99641925
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98925551
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98098537
169* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98097351
170* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98097351
171JUN_21703547_ChIP-Seq_K562_Human0.98033574
172WT1_19549856_ChIP-ChIP_CCG9911_Human0.97989406
173HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97354632
174VDR_21846776_ChIP-Seq_THP-1_Human0.97097168
175FOXP3_21729870_ChIP-Seq_TREG_Human0.96666747
176ELK1_19687146_ChIP-ChIP_HELA_Human0.96502709
177TFEB_21752829_ChIP-Seq_HELA_Human0.96094748
178HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95664181
179CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95354185
180* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94722811
181TCF7_22412390_ChIP-Seq_EML_Mouse0.94709118
182NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94544321
183STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94145069
184UTX_26944678_Chip-Seq_JUKART_Human0.93984831
185* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93808260
186FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92481841
187RUNX1_22412390_ChIP-Seq_EML_Mouse0.91202369
188ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90691992
189ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90473792
190BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87657154
191PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87310629
192STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86407061
193* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85423684
194DCP1A_22483619_ChIP-Seq_HELA_Human0.85415082
195SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84973800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.26998628
2MP0003950_abnormal_plasma_membrane4.62859439
3MP0006054_spinal_hemorrhage3.39849992
4MP0000427_abnormal_hair_cycle3.30317388
5MP0008438_abnormal_cutaneous_collagen3.29620702
6MP0002139_abnormal_hepatobiliary_system3.28904684
7MP0005360_urolithiasis3.24706432
8MP0005503_abnormal_tendon_morphology2.98982042
9MP0003806_abnormal_nucleotide_metabolis2.78993842
10MP0005085_abnormal_gallbladder_physiolo2.68154426
11MP0005365_abnormal_bile_salt2.66712943
12MP0010352_gastrointestinal_tract_polyps2.46997064
13MP0010386_abnormal_urinary_bladder2.41342369
14MP0001958_emphysema2.39729119
15MP0003045_fibrosis2.31102435
16MP0009780_abnormal_chondrocyte_physiolo2.30241028
17MP0003693_abnormal_embryo_hatching2.22454973
18MP0002102_abnormal_ear_morphology2.22383803
19MP0003705_abnormal_hypodermis_morpholog2.10413392
20MP0008057_abnormal_DNA_replication2.10323143
21MP0003890_abnormal_embryonic-extraembry2.07386475
22MP0009384_cardiac_valve_regurgitation2.01120408
23MP0005174_abnormal_tail_pigmentation2.00735799
24MP0005275_abnormal_skin_tensile1.95949558
25MP0003252_abnormal_bile_duct1.95523229
26MP0010094_abnormal_chromosome_stability1.95275662
27MP0003195_calcinosis1.93267937
28MP0004957_abnormal_blastocyst_morpholog1.87527022
29MP0003111_abnormal_nucleus_morphology1.85103437
30MP0002168_other_aberrant_phenotype1.83963393
31MP0009840_abnormal_foam_cell1.82102006
32MP0003279_aneurysm1.79915436
33MP0010307_abnormal_tumor_latency1.78232218
34MP0008875_abnormal_xenobiotic_pharmacok1.76470465
35MP0010234_abnormal_vibrissa_follicle1.71278752
36MP0003937_abnormal_limbs/digits/tail_de1.70597616
37MP0003077_abnormal_cell_cycle1.70206863
38MP0000383_abnormal_hair_follicle1.69521424
39MP0002166_altered_tumor_susceptibility1.63882231
40MP0005076_abnormal_cell_differentiation1.63701871
41MP0006072_abnormal_retinal_apoptosis1.63288181
42MP0003191_abnormal_cellular_cholesterol1.62235664
43MP0004272_abnormal_basement_membrane1.58812976
44MP0001835_abnormal_antigen_presentation1.58609775
45MP0000538_abnormal_urinary_bladder1.58095192
46MP0003566_abnormal_cell_adhesion1.56719059
47MP0004043_abnormal_pH_regulation1.56616922
48MP0002138_abnormal_hepatobiliary_system1.53346583
49MP0002928_abnormal_bile_duct1.48590607
50MP0003091_abnormal_cell_migration1.47491348
51MP0010329_abnormal_lipoprotein_level1.47374372
52MP0002396_abnormal_hematopoietic_system1.46671897
53MP0005187_abnormal_penis_morphology1.44485595
54MP0004142_abnormal_muscle_tone1.43999148
55MP0001542_abnormal_bone_strength1.43386913
56MP0000609_abnormal_liver_physiology1.43103322
57MP0003436_decreased_susceptibility_to1.40784830
58MP0005595_abnormal_vascular_smooth1.39934159
59MP0005171_absent_coat_pigmentation1.39314554
60MP0001800_abnormal_humoral_immune1.36754235
61MP0005623_abnormal_meninges_morphology1.35028606
62MP0001730_embryonic_growth_arrest1.33770096
63MP0010368_abnormal_lymphatic_system1.29613792
64MP0002009_preneoplasia1.29072898
65MP0002006_tumorigenesis1.28171040
66MP0005023_abnormal_wound_healing1.26111242
67MP0001853_heart_inflammation1.26016084
68MP0003300_gastrointestinal_ulcer1.25347494
69MP0001299_abnormal_eye_distance/1.25284954
70MP0000013_abnormal_adipose_tissue1.25214151
71MP0004947_skin_inflammation1.24014259
72MP0005551_abnormal_eye_electrophysiolog1.22571849
73MP0000685_abnormal_immune_system1.22180334
74MP0002938_white_spotting1.21195946
75MP0004264_abnormal_extraembryonic_tissu1.21014209
76MP0009250_abnormal_appendicular_skeleto1.19662699
77MP0002837_dystrophic_cardiac_calcinosis1.17877767
78MP0000350_abnormal_cell_proliferation1.17258011
79MP0004130_abnormal_muscle_cell1.16177525
80MP0005389_reproductive_system_phenotype1.16020525
81MP0005397_hematopoietic_system_phenotyp1.15172601
82MP0001545_abnormal_hematopoietic_system1.15172601
83MP0000647_abnormal_sebaceous_gland1.14116276
84MP0003303_peritoneal_inflammation1.13603633
85MP0002160_abnormal_reproductive_system1.13558791
86MP0005408_hypopigmentation1.13534873
87MP0009278_abnormal_bone_marrow1.12730327
88MP0002086_abnormal_extraembryonic_tissu1.11926260
89MP0008058_abnormal_DNA_repair1.10712932
90MP0005380_embryogenesis_phenotype1.10162087
91MP0001672_abnormal_embryogenesis/_devel1.10162087
92MP0010678_abnormal_skin_adnexa1.09911650
93MP0005332_abnormal_amino_acid1.09908282
94MP0002452_abnormal_antigen_presenting1.08270064
95MP0003941_abnormal_skin_development1.07966190
96MP0003763_abnormal_thymus_physiology1.07636018
97MP0001790_abnormal_immune_system1.07201473
98MP0005387_immune_system_phenotype1.07201473
99MP0002254_reproductive_system_inflammat1.06607831
100MP0005253_abnormal_eye_physiology1.05221146
101MP0003984_embryonic_growth_retardation1.04987683
102MP0000428_abnormal_craniofacial_morphol1.04983109
103MP0002088_abnormal_embryonic_growth/wei1.04968943
104MP0001986_abnormal_taste_sensitivity1.04556734
105MP0003453_abnormal_keratinocyte_physiol1.04485947
106MP0008007_abnormal_cellular_replicative1.04215540
107MP0004134_abnormal_chest_morphology1.04150185
108MP0005319_abnormal_enzyme/_coenzyme1.01487608
109MP0004084_abnormal_cardiac_muscle1.01276857
110MP0000767_abnormal_smooth_muscle1.01148779
111MP0000689_abnormal_spleen_morphology1.01012783
112MP0000598_abnormal_liver_morphology1.00861155
113MP0002398_abnormal_bone_marrow1.00586271
114MP0008775_abnormal_heart_ventricle0.97891540
115MP0004808_abnormal_hematopoietic_stem0.97886552
116MP0002019_abnormal_tumor_incidence0.97554572
117MP0004019_abnormal_vitamin_homeostasis0.97427764
118MP0005670_abnormal_white_adipose0.97150524
119MP0003755_abnormal_palate_morphology0.96675311
120MP0005395_other_phenotype0.96440083
121MP0001873_stomach_inflammation0.96377683
122MP0004197_abnormal_fetal_growth/weight/0.96309706
123MP0002723_abnormal_immune_serum0.94207337
124MP0009053_abnormal_anal_canal0.93555932
125MP0009763_increased_sensitivity_to0.93263858
126MP0002332_abnormal_exercise_endurance0.92577988
127MP0002108_abnormal_muscle_morphology0.92477235
128MP0002722_abnormal_immune_system0.92129514
129MP0005000_abnormal_immune_tolerance0.91433046
130MP0000015_abnormal_ear_pigmentation0.91424499
131MP0001666_abnormal_nutrient_absorption0.91204958
132MP0003186_abnormal_redox_activity0.90599518
133MP0002109_abnormal_limb_morphology0.89965797
134MP0000516_abnormal_urinary_system0.89480766
135MP0005367_renal/urinary_system_phenotyp0.89480766
136MP0002419_abnormal_innate_immunity0.89321662
137MP0002877_abnormal_melanocyte_morpholog0.89274535
138MP0000858_altered_metastatic_potential0.89171257
139MP0004484_altered_response_of0.89135183
140MP0010155_abnormal_intestine_physiology0.89115197
141MP0005671_abnormal_response_to0.88845858
142MP0002420_abnormal_adaptive_immunity0.88514293
143MP0001764_abnormal_homeostasis0.88502784
144MP0001845_abnormal_inflammatory_respons0.88301148
145MP0001819_abnormal_immune_cell0.87918455
146MP0002796_impaired_skin_barrier0.87704107
147MP0003567_abnormal_fetal_cardiomyocyte0.87382516
148MP0005025_abnormal_response_to0.86614995
149MP0005464_abnormal_platelet_physiology0.85851890
150MP0008877_abnormal_DNA_methylation0.85792681
151MP0000716_abnormal_immune_system0.85082932
152MP0001915_intracranial_hemorrhage0.84969796
153MP0001697_abnormal_embryo_size0.83549102
154MP0000371_diluted_coat_color0.82807284
155MP0008469_abnormal_protein_level0.82498801
156MP0002896_abnormal_bone_mineralization0.81931928
157MP0001216_abnormal_epidermal_layer0.81439542
158MP0002080_prenatal_lethality0.81402493
159MP0002429_abnormal_blood_cell0.81257582
160MP0009785_altered_susceptibility_to0.80875478
161MP0003448_altered_tumor_morphology0.80839517
162MP0005666_abnormal_adipose_tissue0.80338315
163MP0002115_abnormal_skeleton_extremities0.79973401
164MP0001243_abnormal_dermal_layer0.79757057
165MP0009643_abnormal_urine_homeostasis0.78743620
166MP0000230_abnormal_systemic_arterial0.78396627
167MP0003786_premature_aging0.78343412
168MP0009697_abnormal_copulation0.76340065
169MP0002234_abnormal_pharynx_morphology0.76185104
170MP0000534_abnormal_ureter_morphology0.73207430
171MP0001879_abnormal_lymphatic_vessel0.70295171
172MP0003943_abnormal_hepatobiliary_system0.69364672
173MP0005508_abnormal_skeleton_morphology0.69173267
174MP0000470_abnormal_stomach_morphology0.68089992
175MP0002876_abnormal_thyroid_physiology0.67700053
176MP0002295_abnormal_pulmonary_circulatio0.66087911
177MP0003828_pulmonary_edema0.66042594
178MP0005164_abnormal_response_to0.64988597
179MP0004133_heterotaxia0.64793979
180MP0002095_abnormal_skin_pigmentation0.64693073
181MP0000432_abnormal_head_morphology0.64572145
182MP0005620_abnormal_muscle_contractility0.63118347
183MP0002751_abnormal_autonomic_nervous0.63092054
184MP0002128_abnormal_blood_circulation0.62803575
185MP0004883_abnormal_blood_vessel0.61937743
186MP0003942_abnormal_urinary_system0.61372030
187MP0003868_abnormal_feces_composition0.61093965
188MP0004924_abnormal_behavior0.59712782
189MP0005386_behavior/neurological_phenoty0.59712782

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.02740906
2Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90472063
3Hyperventilation (HP:0002883)3.79114930
4Pancreatic cysts (HP:0001737)3.71914505
5Hypobetalipoproteinemia (HP:0003563)3.68156580
6Xanthomatosis (HP:0000991)3.48981655
7Pancreatic fibrosis (HP:0100732)3.46561975
8Deep venous thrombosis (HP:0002625)3.38131702
9Abnormality of DNA repair (HP:0003254)3.20390889
10Complement deficiency (HP:0004431)3.15895274
11Abnormality of pyrimidine metabolism (HP:0004353)3.06865213
12Abnormality of the renal cortex (HP:0011035)3.06009704
13Genetic anticipation (HP:0003743)3.02618693
14Hypolipoproteinemia (HP:0010981)3.00873139
15Myocardial infarction (HP:0001658)2.99760421
16Tubular atrophy (HP:0000092)2.94582449
17True hermaphroditism (HP:0010459)2.92904743
18Abnormality of midbrain morphology (HP:0002418)2.85484661
19Molar tooth sign on MRI (HP:0002419)2.85484661
20Aortic aneurysm (HP:0004942)2.83674226
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82393676
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79044708
23Abnormality of alanine metabolism (HP:0010916)2.79044708
24Hyperalaninemia (HP:0003348)2.79044708
25Abnormality of sulfur amino acid metabolism (HP:0004339)2.77168167
26Increased number of teeth (HP:0011069)2.74977582
27Fair hair (HP:0002286)2.73725574
28Spastic diplegia (HP:0001264)2.73710769
29Recurrent gram-negative bacterial infections (HP:0005420)2.72945144
30Progressive inability to walk (HP:0002505)2.72370605
31Protruding tongue (HP:0010808)2.72365185
32Abnormality of complement system (HP:0005339)2.72361534
33Hypoalphalipoproteinemia (HP:0003233)2.69521004
34Hyperglycinuria (HP:0003108)2.67273921
35Aortic dissection (HP:0002647)2.65884890
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.63818962
37Mesomelia (HP:0003027)2.60553856
38Short chin (HP:0000331)2.59023216
39Hypoplasia of the pons (HP:0012110)2.58121057
40Abnormality of the nasal septum (HP:0000419)2.57384702
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.57289074
42Epidermoid cyst (HP:0200040)2.55456773
43Ependymoma (HP:0002888)2.54447333
44Hyperglycinemia (HP:0002154)2.53090631
45Abnormality of the pons (HP:0007361)2.52060889
46Prolonged partial thromboplastin time (HP:0003645)2.51071129
47Aplasia of the musculature (HP:0100854)2.50372873
48Nephronophthisis (HP:0000090)2.50120160
49Pustule (HP:0200039)2.49933001
50Chorioretinal atrophy (HP:0000533)2.48633486
51Abnormality of the ischium (HP:0003174)2.47764389
52Increased corneal curvature (HP:0100692)2.46866942
53Keratoconus (HP:0000563)2.46866942
54Abnormality of the renal medulla (HP:0100957)2.45802649
55Upper motor neuron abnormality (HP:0002127)2.44536333
56Abnormality of the common coagulation pathway (HP:0010990)2.43901156
57Eczematoid dermatitis (HP:0000976)2.41007695
58Hypochromic microcytic anemia (HP:0004840)2.39715085
59Abnormality of serine family amino acid metabolism (HP:0010894)2.39458282
60Abnormality of glycine metabolism (HP:0010895)2.39458282
61Hypoplastic ischia (HP:0003175)2.38502963
62Follicular hyperkeratosis (HP:0007502)2.35375856
63Attenuation of retinal blood vessels (HP:0007843)2.34828393
64Systemic lupus erythematosus (HP:0002725)2.34745441
65Entropion (HP:0000621)2.33099376
66Agnosia (HP:0010524)2.32618745
67Hyperammonemia (HP:0001987)2.31891229
68Inability to walk (HP:0002540)2.30870704
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30169219
70Small hand (HP:0200055)2.29821541
71Gaze-evoked nystagmus (HP:0000640)2.27581725
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.27452677
73Osteolytic defects of the hand bones (HP:0009699)2.27452677
74Increased mean platelet volume (HP:0011877)2.27386413
75Joint hemorrhage (HP:0005261)2.26478455
76Abnormal platelet volume (HP:0011876)2.26284303
77Renal cortical cysts (HP:0000803)2.25708480
78Hematochezia (HP:0002573)2.24780931
79Biliary tract neoplasm (HP:0100574)2.22730543
80Cerebellar dysplasia (HP:0007033)2.22667038
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.22407245
82Hepatocellular carcinoma (HP:0001402)2.21079314
83Nasal polyposis (HP:0100582)2.19296103
84Chronic hepatic failure (HP:0100626)2.18661330
85Aplasia/Hypoplasia involving the musculature (HP:0001460)2.16518320
86Generalized hypopigmentation of hair (HP:0011358)2.14796491
87Cystic liver disease (HP:0006706)2.14401034
88Esophageal varix (HP:0002040)2.13607010
89Abnormality of nucleobase metabolism (HP:0010932)2.13052080
90Hypoproteinemia (HP:0003075)2.13010519
91Short hallux (HP:0010109)2.12792233
92Hyperlipoproteinemia (HP:0010980)2.12592232
93Absent frontal sinuses (HP:0002688)2.10417180
94Impulsivity (HP:0100710)2.10209357
95Hypoglycemic coma (HP:0001325)2.10082362
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.08694319
97Facial diplegia (HP:0001349)2.08689556
98Abnormality of methionine metabolism (HP:0010901)2.08427317
99Bulbous nose (HP:0000414)2.08273721
100Selective tooth agenesis (HP:0001592)2.07487400
101Birth length less than 3rd percentile (HP:0003561)2.05755604
102Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05480112
103Clubbing of toes (HP:0100760)2.05319284
104Fat malabsorption (HP:0002630)2.02650142
105Thrombophlebitis (HP:0004418)2.02494839
106Aplasia/Hypoplasia of the hallux (HP:0008362)2.02369258
107Decreased subcutaneous fat (HP:0001002)2.00700072
108Gingival bleeding (HP:0000225)1.99950267
109Absent speech (HP:0001344)1.99932118
110Furrowed tongue (HP:0000221)1.98662924
111Vascular tortuosity (HP:0004948)1.98601661
112Abnormal albumin level (HP:0012116)1.98334474
113Hypoalbuminemia (HP:0003073)1.98334474
114Short 1st metacarpal (HP:0010034)1.98329369
115Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98329369
116Premature rupture of membranes (HP:0001788)1.98204113
117Soft skin (HP:0000977)1.96100829
118Widely spaced teeth (HP:0000687)1.94437060
119Hypercholesterolemia (HP:0003124)1.94426140
120Abnormality of proline metabolism (HP:0010907)1.92697572
121Hydroxyprolinuria (HP:0003080)1.92697572
122Basal cell carcinoma (HP:0002671)1.92228896
123IgM deficiency (HP:0002850)1.91697651
124Congenital stationary night blindness (HP:0007642)1.91626501
125Hypoplastic nipples (HP:0002557)1.91391591
126Recurrent bronchitis (HP:0002837)1.91049327
127Rhabdomyosarcoma (HP:0002859)1.90754998
128Spondylolisthesis (HP:0003302)1.90569681
129Medial flaring of the eyebrow (HP:0010747)1.90334351
130Type II lissencephaly (HP:0007260)1.89694825
131Amaurosis fugax (HP:0100576)1.89421708
132Gastrointestinal infarctions (HP:0005244)1.89031018
133Short foot (HP:0001773)1.88685210
134Hypochromic anemia (HP:0001931)1.88593064
135Clumsiness (HP:0002312)1.87587272
136Colon cancer (HP:0003003)1.86623063
137Abnormality of lateral ventricle (HP:0030047)1.85338585
138Abnormality of the nasal mucosa (HP:0000433)1.85212494
139Abnormality of the renal collecting system (HP:0004742)1.82708892
140Duplicated collecting system (HP:0000081)1.82708496
141Glucose intolerance (HP:0000833)1.82310822
142Hypoplastic labia majora (HP:0000059)1.80548656
143Recurrent bacterial skin infections (HP:0005406)1.80269880
144Abnormal biliary tract morphology (HP:0012440)1.80058472
145Cortical dysplasia (HP:0002539)1.80018908
146Hypoplastic iliac wings (HP:0002866)1.79580939
147Abnormality of the frontal sinuses (HP:0002687)1.78517691
148Abnormality of the ileum (HP:0001549)1.78260980
149Abnormality of the intrinsic pathway (HP:0010989)1.76117683
150Abnormality of the axillary hair (HP:0100134)1.75401532
151Abnormality of secondary sexual hair (HP:0009888)1.75401532
152Arterial tortuosity (HP:0005116)1.74708466
153Arterial thrombosis (HP:0004420)1.74631849
154Recurrent viral infections (HP:0004429)1.74589696
155Congenital hepatic fibrosis (HP:0002612)1.73654945
156Congenital, generalized hypertrichosis (HP:0004540)1.72977285
157Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72927307
158Vascular calcification (HP:0004934)1.72545316
159Delayed gross motor development (HP:0002194)1.72274824
160Abnormality of the labia majora (HP:0012881)1.71876902
161Conjunctival telangiectasia (HP:0000524)1.71534570
162Abnormality of iron homeostasis (HP:0011031)1.71161852
163Myositis (HP:0100614)1.70715198
164Abnormality of transition element cation homeostasis (HP:0011030)1.69488914
165Spontaneous hematomas (HP:0007420)1.69037514
166Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68736442
167Thrombocytosis (HP:0001894)1.68728901
168Abnormality of serum amino acid levels (HP:0003112)1.68173963
169Abnormality of the fingertips (HP:0001211)1.68161808
170Chromsome breakage (HP:0040012)1.68026519
171Astigmatism (HP:0000483)1.67881791
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67845760
173Progressive cerebellar ataxia (HP:0002073)1.67741632
174Abnormal cartilage morphology (HP:0002763)1.66741474
175Ectopic kidney (HP:0000086)1.66640340
176Recurrent sinusitis (HP:0011108)1.66368907
177Abnormality of purine metabolism (HP:0004352)1.66145514
178Anorexia (HP:0002039)1.65344687
179Radial bowing (HP:0002986)1.64136199
180Abnormal glucose tolerance (HP:0001952)1.63715394
181Meckel diverticulum (HP:0002245)1.63632351
182Periodontitis (HP:0000704)1.63595872
183Morphological abnormality of the middle ear (HP:0008609)1.63494598
184Metaphyseal cupping (HP:0003021)1.61799480
185Gangrene (HP:0100758)1.61484541
186Ascites (HP:0001541)1.61432025
187Hemorrhage of the eye (HP:0011885)1.60402970
188Ketosis (HP:0001946)1.59708368
189Glomerulonephritis (HP:0000099)1.58401005
190Abnormality of chromosome stability (HP:0003220)1.58340957
191Recurrent abscess formation (HP:0002722)1.57761233
192Nephritis (HP:0000123)1.57083315
193Autoimmune thrombocytopenia (HP:0001973)1.56747460
194Cardiovascular calcification (HP:0011915)1.56499213
195Medulloblastoma (HP:0002885)1.56390782
196Acanthocytosis (HP:0001927)1.54861094
197T lymphocytopenia (HP:0005403)1.54516298
198Orchitis (HP:0100796)1.54503623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.57605197
2BMPR1B3.37842619
3CDK123.06549293
4STK102.48501302
5PKN22.25105199
6NEK22.22593921
7MAP4K12.19160987
8WEE12.15924239
9MAP3K102.12852592
10WNK42.04333412
11ADRBK22.02437009
12ACVR1B2.01209394
13EPHA22.00895775
14CDC71.91709174
15FGFR41.82089670
16TYK21.81057202
17EEF2K1.80271025
18GRK11.78100685
19FLT31.76884123
20MYLK1.72825567
21LATS11.70189937
22PDK41.69206235
23PDK31.69206235
24RPS6KB21.59343544
25STK31.59044248
26CDK61.57768160
27CAMKK21.54687242
28STK391.54513831
29CDK41.51736706
30TTK1.50067476
31PLK21.46800137
32RPS6KA41.46528761
33NUAK11.44409585
34PAK31.43929433
35ERN11.43631024
36MKNK21.43099831
37OXSR11.41497696
38ADRBK11.40300410
39TAOK31.36552849
40NEK11.36127775
41GRK61.33283806
42PNCK1.33118786
43MAP2K31.31216577
44MELK1.30628223
45ERBB31.30112569
46MAP3K81.29121709
47PIK3CG1.27441731
48PTK2B1.25086216
49PIM11.24599979
50TLK11.23227498
51STK41.23212295
52MAP3K31.18243559
53PDK21.15580166
54ERBB41.10151575
55TGFBR21.08665885
56EIF2AK11.08012745
57JAK31.07433774
58PRKCE1.07129903
59WNK11.06371722
60JAK11.05596045
61CSF1R1.04498757
62ATR1.02448662
63CDK71.02361316
64BCKDK1.01824451
65PIK3CA1.01070704
66TGFBR11.00765550
67TTN1.00683150
68BRD40.99976842
69ZAP700.99697613
70PASK0.99573066
71TSSK60.99267815
72LRRK20.98186495
73PAK40.97417951
74STK380.97360582
75PTK60.96297766
76CASK0.96249254
77MAP3K140.96223783
78STK38L0.95301473
79BRSK20.95244207
80BUB10.95085934
81SCYL20.94544613
82FGFR30.94491160
83PLK10.94432885
84AURKB0.92921164
85CSK0.91250275
86TXK0.89235120
87FRK0.88977324
88MST40.88825602
89PDGFRB0.88797804
90NEK90.87222986
91DYRK30.87185017
92CAMK1G0.84877368
93SGK20.84870184
94CHEK10.82183710
95MAPK110.81384702
96ITK0.81066362
97INSRR0.79696557
98PAK20.78811987
99MTOR0.77679524
100SRPK10.77273006
101EIF2AK30.77185483
102CAMK1D0.76202948
103JAK20.75735954
104GRK70.74147458
105MET0.73443981
106MAP2K10.72368615
107MST1R0.72063066
108PTK20.72021455
109MAP3K40.71562377
110DDR20.71336035
111BTK0.71163943
112TRIB30.70269604
113IKBKB0.69668597
114MAPK130.68856159
115KIT0.68697066
116CHUK0.67088939
117ALK0.66521799
118RIPK10.66392539
119MKNK10.66332743
120MARK30.65290842
121ATM0.64909234
122FGFR10.62839793
123CDK90.62376450
124TBK10.61224421
125TESK20.61149136
126BLK0.61052343
127TESK10.60659381
128LIMK10.60408386
129CHEK20.59499776
130TRPM70.59196862
131NLK0.58025311
132SIK10.57418258
133PINK10.56564993
134MAP4K20.56020646
135TEC0.55988575
136PLK40.53592733
137LCK0.53238535
138FER0.52805427
139PLK30.52596454
140PRKD20.51661509
141CDK20.50435039
142IKBKE0.50371209
143MAPKAPK30.48968928
144SGK30.48827871
145PDK10.46548002
146MUSK0.46155996
147BMPR20.45721253
148DAPK20.43654776
149WNK30.40661139
150HCK0.40223258
151YES10.40164881
152MAP3K60.39720090
153EGFR0.39714762
154TIE10.38949725
155ABL10.38713019
156CSNK1D0.38675496
157ZAK0.38295536
158PAK60.37132893
159ROCK10.36059772
160PDGFRA0.32945534
161CAMK2A0.30991758
162MARK10.29597142
163IGF1R0.26720957
164SGK2230.25991450
165SGK4940.25991450
166MAPK70.25898772
167INSR0.25551285
168GSK3A0.25220216
169MAP3K120.22740371
170CSNK1A1L0.21446862
171BCR0.20158476
172FGFR20.19905618

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.68444307
2Nitrogen metabolism_Homo sapiens_hsa009102.65432642
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23691294
4One carbon pool by folate_Homo sapiens_hsa006702.21754079
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12272611
6Caffeine metabolism_Homo sapiens_hsa002322.03800783
7Selenocompound metabolism_Homo sapiens_hsa004502.00963120
8Staphylococcus aureus infection_Homo sapiens_hsa051501.97564096
9Complement and coagulation cascades_Homo sapiens_hsa046101.93338792
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90196025
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85850887
12Arginine biosynthesis_Homo sapiens_hsa002201.82006816
13Dorso-ventral axis formation_Homo sapiens_hsa043201.79915043
14DNA replication_Homo sapiens_hsa030301.76280064
15TGF-beta signaling pathway_Homo sapiens_hsa043501.75397109
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75165325
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71492031
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69391368
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68081916
20Mismatch repair_Homo sapiens_hsa034301.67281225
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66515941
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66187749
23ECM-receptor interaction_Homo sapiens_hsa045121.63628522
24Linoleic acid metabolism_Homo sapiens_hsa005911.61190883
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59522234
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58189936
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57142123
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55875593
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55719775
30Fatty acid degradation_Homo sapiens_hsa000711.54150516
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53370640
32Tryptophan metabolism_Homo sapiens_hsa003801.47443361
33Ether lipid metabolism_Homo sapiens_hsa005651.46705811
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45471520
35RNA transport_Homo sapiens_hsa030131.45032067
36Taste transduction_Homo sapiens_hsa047421.42868428
37Phototransduction_Homo sapiens_hsa047441.35380360
38Basal transcription factors_Homo sapiens_hsa030221.34068563
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29428890
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27565438
41Focal adhesion_Homo sapiens_hsa045101.27472462
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25329251
43Biosynthesis of amino acids_Homo sapiens_hsa012301.23969126
44Circadian rhythm_Homo sapiens_hsa047101.23124287
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.22860390
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.21867368
47Melanoma_Homo sapiens_hsa052181.21468706
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21453022
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21127350
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20369986
51Sulfur metabolism_Homo sapiens_hsa009201.20310141
52Chemical carcinogenesis_Homo sapiens_hsa052041.18454673
53Antigen processing and presentation_Homo sapiens_hsa046121.17396762
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17180772
55PPAR signaling pathway_Homo sapiens_hsa033201.16889470
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16839021
57Systemic lupus erythematosus_Homo sapiens_hsa053221.15502870
58Hippo signaling pathway_Homo sapiens_hsa043901.15475398
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15019223
60Carbon metabolism_Homo sapiens_hsa012001.13622516
61Proteoglycans in cancer_Homo sapiens_hsa052051.13047035
62Cell cycle_Homo sapiens_hsa041101.12887303
63Propanoate metabolism_Homo sapiens_hsa006401.09402417
64Pentose phosphate pathway_Homo sapiens_hsa000301.08375744
65Lysine degradation_Homo sapiens_hsa003101.07475623
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04303370
67Vitamin B6 metabolism_Homo sapiens_hsa007501.03876470
68Hedgehog signaling pathway_Homo sapiens_hsa043401.03518184
69Peroxisome_Homo sapiens_hsa041461.03251024
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02956520
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02277261
72beta-Alanine metabolism_Homo sapiens_hsa004100.99159084
73Spliceosome_Homo sapiens_hsa030400.98806106
74Calcium signaling pathway_Homo sapiens_hsa040200.98129181
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97398825
76Folate biosynthesis_Homo sapiens_hsa007900.96590834
77Morphine addiction_Homo sapiens_hsa050320.96489104
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96040481
79Base excision repair_Homo sapiens_hsa034100.95510856
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.95053856
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93341639
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92931502
83Legionellosis_Homo sapiens_hsa051340.92156922
84p53 signaling pathway_Homo sapiens_hsa041150.91029434
85Herpes simplex infection_Homo sapiens_hsa051680.90417140
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90335224
87Histidine metabolism_Homo sapiens_hsa003400.90190740
88Fatty acid metabolism_Homo sapiens_hsa012120.88390624
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.88212639
90Retinol metabolism_Homo sapiens_hsa008300.87958110
91Phenylalanine metabolism_Homo sapiens_hsa003600.87811257
92Pyruvate metabolism_Homo sapiens_hsa006200.87475072
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86978202
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.85830145
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.85265913
96Nucleotide excision repair_Homo sapiens_hsa034200.85237892
97Starch and sucrose metabolism_Homo sapiens_hsa005000.84998200
98Glutathione metabolism_Homo sapiens_hsa004800.79329597
99Oxytocin signaling pathway_Homo sapiens_hsa049210.78628966
100Sphingolipid metabolism_Homo sapiens_hsa006000.76810248
101ABC transporters_Homo sapiens_hsa020100.76423730
102Viral carcinogenesis_Homo sapiens_hsa052030.75121954
103Axon guidance_Homo sapiens_hsa043600.73209495
104Platelet activation_Homo sapiens_hsa046110.71569829
105MicroRNAs in cancer_Homo sapiens_hsa052060.71280956
106Serotonergic synapse_Homo sapiens_hsa047260.71112652
107Small cell lung cancer_Homo sapiens_hsa052220.70626391
108Fanconi anemia pathway_Homo sapiens_hsa034600.69790908
109Dilated cardiomyopathy_Homo sapiens_hsa054140.69758711
110Regulation of autophagy_Homo sapiens_hsa041400.69201849
111Long-term depression_Homo sapiens_hsa047300.69065857
112Leishmaniasis_Homo sapiens_hsa051400.68751559
113cAMP signaling pathway_Homo sapiens_hsa040240.68731863
114Olfactory transduction_Homo sapiens_hsa047400.68578189
115Salivary secretion_Homo sapiens_hsa049700.68514770
116Pathways in cancer_Homo sapiens_hsa052000.68147461
117Primary immunodeficiency_Homo sapiens_hsa053400.67496975
118Renin secretion_Homo sapiens_hsa049240.66937359
119FoxO signaling pathway_Homo sapiens_hsa040680.66891049
120mRNA surveillance pathway_Homo sapiens_hsa030150.66618938
121Glutamatergic synapse_Homo sapiens_hsa047240.66282541
122Measles_Homo sapiens_hsa051620.65815549
123B cell receptor signaling pathway_Homo sapiens_hsa046620.65663139
124Non-homologous end-joining_Homo sapiens_hsa034500.64954072
125Epstein-Barr virus infection_Homo sapiens_hsa051690.64398802
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63924582
127Fat digestion and absorption_Homo sapiens_hsa049750.61823377
128RNA degradation_Homo sapiens_hsa030180.61621927
129Sulfur relay system_Homo sapiens_hsa041220.61506273
130Vitamin digestion and absorption_Homo sapiens_hsa049770.61048879
131Circadian entrainment_Homo sapiens_hsa047130.60724714
132Ovarian steroidogenesis_Homo sapiens_hsa049130.60246195
133Protein digestion and absorption_Homo sapiens_hsa049740.59573388
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59021097
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58797032
136Insulin secretion_Homo sapiens_hsa049110.58425707
137Pyrimidine metabolism_Homo sapiens_hsa002400.57598560
138Homologous recombination_Homo sapiens_hsa034400.57205912
139Nicotine addiction_Homo sapiens_hsa050330.56047373
140MAPK signaling pathway_Homo sapiens_hsa040100.55876996
141Glycerolipid metabolism_Homo sapiens_hsa005610.55572211
142Tyrosine metabolism_Homo sapiens_hsa003500.55399616
143Fructose and mannose metabolism_Homo sapiens_hsa000510.54050605
144Ras signaling pathway_Homo sapiens_hsa040140.52481966
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.52219395
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51648862
147Insulin resistance_Homo sapiens_hsa049310.51414298
148TNF signaling pathway_Homo sapiens_hsa046680.50594931
149Toxoplasmosis_Homo sapiens_hsa051450.50402711
150Influenza A_Homo sapiens_hsa051640.50224791
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49978267
152Apoptosis_Homo sapiens_hsa042100.49882286
153Thyroid hormone synthesis_Homo sapiens_hsa049180.49450278
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47662535
155Cholinergic synapse_Homo sapiens_hsa047250.47538065
156* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47510179
157Bile secretion_Homo sapiens_hsa049760.47363179
158Prostate cancer_Homo sapiens_hsa052150.46841382
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46702300
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45991472
161N-Glycan biosynthesis_Homo sapiens_hsa005100.44972658
162Basal cell carcinoma_Homo sapiens_hsa052170.44926524
163Gastric acid secretion_Homo sapiens_hsa049710.43632824
164Osteoclast differentiation_Homo sapiens_hsa043800.42654168
165Leukocyte transendothelial migration_Homo sapiens_hsa046700.42292608
166Galactose metabolism_Homo sapiens_hsa000520.41764474
167Hematopoietic cell lineage_Homo sapiens_hsa046400.40245485
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.38635204
169Butanoate metabolism_Homo sapiens_hsa006500.38281992
170Adherens junction_Homo sapiens_hsa045200.37841253

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