HERC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome organization involved in meiosis (GO:0070192)9.96817039
2male meiosis I (GO:0007141)9.87593245
3synaptonemal complex assembly (GO:0007130)8.85071622
4DNA synthesis involved in DNA repair (GO:0000731)8.77670045
5male meiosis (GO:0007140)8.05770787
6synaptonemal complex organization (GO:0070193)7.94106362
7meiosis I (GO:0007127)7.91822919
8DNA methylation involved in gamete generation (GO:0043046)7.83705022
9meiotic nuclear division (GO:0007126)7.15766494
10regulation of meiosis I (GO:0060631)6.07861679
11sister chromatid cohesion (GO:0007062)5.57507687
12type I interferon signaling pathway (GO:0060337)5.36977356
13cellular response to type I interferon (GO:0071357)5.36977356
14histone H3-K36 demethylation (GO:0070544)5.34647804
15meiotic cell cycle process (GO:1903046)5.31224453
16response to type I interferon (GO:0034340)5.27990761
17histone H3-K9 demethylation (GO:0033169)4.92749416
18cellular response to interferon-alpha (GO:0035457)4.62545684
19regulation of interferon-alpha production (GO:0032647)4.43044771
20response to interferon-alpha (GO:0035455)4.37420476
21reciprocal DNA recombination (GO:0035825)4.32075824
22reciprocal meiotic recombination (GO:0007131)4.32075824
23positive regulation of interferon-alpha production (GO:0032727)4.14336603
24negative regulation of viral genome replication (GO:0045071)4.00333323
25meiotic chromosome segregation (GO:0045132)3.98433677
26mitotic sister chromatid cohesion (GO:0007064)3.96018404
27regulation of T-helper 1 cell differentiation (GO:0045625)3.77778863
28gene silencing by RNA (GO:0031047)3.75887071
29negative regulation of interleukin-12 production (GO:0032695)3.59335062
30regulation of RIG-I signaling pathway (GO:0039535)3.51343463
31signal complex assembly (GO:0007172)3.47608280
32resolution of meiotic recombination intermediates (GO:0000712)3.39953408
33female gamete generation (GO:0007292)3.37857734
34regulation of MHC class I biosynthetic process (GO:0045343)3.36721090
35negative regulation of inclusion body assembly (GO:0090084)3.34683468
36response to peptidoglycan (GO:0032494)3.34509981
37positive regulation of interferon-beta production (GO:0032728)3.31208162
38positive regulation by symbiont of host defense response (GO:0052509)3.18673169
39modulation by symbiont of host defense response (GO:0052031)3.18673169
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18673169
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18673169
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.18673169
43modulation by symbiont of host immune response (GO:0052553)3.18673169
44positive regulation of meiosis (GO:0045836)3.18508053
45macrophage activation involved in immune response (GO:0002281)3.16826937
46regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.16073471
47regulation of vitamin D biosynthetic process (GO:0060556)3.11952344
48positive regulation of type 2 immune response (GO:0002830)3.11680911
49regulation of transcription from RNA polymerase I promoter (GO:0006356)3.11472035
50regulation of interferon-beta production (GO:0032648)3.09234058
51negative regulation of cell killing (GO:0031342)3.08896709
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08896709
53positive regulation of gamma-delta T cell activation (GO:0046645)3.04286996
54negative regulation of gene silencing (GO:0060969)3.00794241
55interferon-gamma-mediated signaling pathway (GO:0060333)2.99974053
56regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97679963
57regulation of protein polyubiquitination (GO:1902914)2.95391436
58* negative regulation of type I interferon production (GO:0032480)2.94278329
59positive regulation of meiotic cell cycle (GO:0051446)2.91693157
60response to interferon-beta (GO:0035456)2.91682201
61negative regulation of defense response to virus (GO:0050687)2.90726160
62negative regulation of NF-kappaB import into nucleus (GO:0042347)2.90526724
63negative regulation of T cell mediated immunity (GO:0002710)2.89648589
64regulation of DNA endoreduplication (GO:0032875)2.87411429
65regulation of interferon-beta biosynthetic process (GO:0045357)2.86187940
66regulation of cytokine secretion involved in immune response (GO:0002739)2.85484275
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85256129
68DNA alkylation (GO:0006305)2.84050501
69DNA methylation (GO:0006306)2.84050501
70positive regulation of T cell cytokine production (GO:0002726)2.83833294
71immunoglobulin mediated immune response (GO:0016064)2.83776161
72regulation of NFAT protein import into nucleus (GO:0051532)2.81003530
73histone lysine demethylation (GO:0070076)2.80367308
74cellular response to exogenous dsRNA (GO:0071360)2.76035893
75cellular response to virus (GO:0098586)2.74651319
76regulation of viral genome replication (GO:0045069)2.74490088
77histone demethylation (GO:0016577)2.74061137
78regulation of type 2 immune response (GO:0002828)2.73803406
79regulation of chronic inflammatory response (GO:0002676)2.73529931
80* defense response to virus (GO:0051607)2.72487814
81regulation of meiotic cell cycle (GO:0051445)2.69021696
82positive regulation of response to oxidative stress (GO:1902884)2.68786221
83positive regulation of cellular response to oxidative stress (GO:1900409)2.68786221
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.68369452
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68145980
86defense response to protozoan (GO:0042832)2.66708592
87T cell migration (GO:0072678)2.63395355
88detection of molecule of bacterial origin (GO:0032490)2.60377887
89cellular response to interferon-beta (GO:0035458)2.58184059
90protein localization to chromosome (GO:0034502)2.57621745
91oogenesis (GO:0048477)2.55569500
92regulation of T-helper 2 cell differentiation (GO:0045628)2.54811365
93regulation of histone H3-K9 methylation (GO:0051570)2.54473367
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52750617
95interferon-gamma secretion (GO:0072643)2.52645579
96regulation of T cell cytokine production (GO:0002724)2.52366442
97negative regulation of type 2 immune response (GO:0002829)2.51315689
98B cell mediated immunity (GO:0019724)2.50380908
99synapsis (GO:0007129)12.6748493
100piRNA metabolic process (GO:0034587)10.2247468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.39252336
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.46368091
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.36645673
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.80375104
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.42163987
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58833018
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.46245975
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.15393115
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14071601
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.04253584
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77046339
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73832603
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55765835
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51906409
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.50120378
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39830178
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29803502
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23349177
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22926802
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22926802
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22926802
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07893936
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99763617
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93534805
25SPI1_23547873_ChIP-Seq_NB4_Human1.90924412
26E2F7_22180533_ChIP-Seq_HELA_Human1.85750348
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85512851
28MYB_26560356_Chip-Seq_TH2_Human1.85431997
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84534178
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.82227872
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.81627589
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71882502
33MYB_26560356_Chip-Seq_TH1_Human1.65162497
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59980653
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53211071
36GATA3_27048872_Chip-Seq_THYMUS_Human1.48889132
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48078954
38TFEB_21752829_ChIP-Seq_HELA_Human1.47923107
39RUNX_20019798_ChIP-Seq_JUKART_Human1.45559852
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42449117
41GATA1_22025678_ChIP-Seq_K562_Human1.41888842
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.36399598
43VDR_24787735_ChIP-Seq_THP-1_Human1.35754637
44GATA3_26560356_Chip-Seq_TH2_Human1.34788971
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30948949
46MAF_26560356_Chip-Seq_TH1_Human1.27940783
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24279247
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24229075
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19624821
50CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18892371
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16844879
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16664644
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14469879
54UTX_26944678_Chip-Seq_JUKART_Human1.12461016
55GATA3_26560356_Chip-Seq_TH1_Human1.12291547
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11940542
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10727338
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10369271
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09919411
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09144846
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08730934
62VDR_24763502_ChIP-Seq_THP-1_Human1.07872845
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07237912
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05129044
65MAF_26560356_Chip-Seq_TH2_Human1.04898429
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02437680
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02422364
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01322201
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.00537052
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99979164
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98765054
72IGF1R_20145208_ChIP-Seq_DFB_Human0.97326612
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97165330
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97159911
75ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97082616
76MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95020007
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94379903
78VDR_21846776_ChIP-Seq_THP-1_Human0.91940010
79PU_27001747_Chip-Seq_BMDM_Mouse0.91688689
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90786792
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88047985
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87182553
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86306654
84TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85888011
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85814357
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85061059
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.83764368
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81244565
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79231354
90RNF2_27304074_Chip-Seq_NSC_Mouse0.78885719
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77607023
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77052112
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77005828
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75976869
95SPI1_23127762_ChIP-Seq_K562_Human0.75619156
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73432767
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68858230
98BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.67363600
99DCP1A_22483619_ChIP-Seq_HELA_Human0.67326186
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65352655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.31018530
2MP0003303_peritoneal_inflammation3.97313852
3MP0003724_increased_susceptibility_to3.65911418
4MP0001835_abnormal_antigen_presentation3.15991356
5MP0009785_altered_susceptibility_to2.92624646
6MP0006082_CNS_inflammation2.91072099
7MP0008004_abnormal_stomach_pH2.79776983
8MP0002210_abnormal_sex_determination2.76111175
9MP0003436_decreased_susceptibility_to2.49810738
10MP0008058_abnormal_DNA_repair2.38578354
11MP0002148_abnormal_hypersensitivity_rea2.35622508
12MP0001929_abnormal_gametogenesis2.29370101
13MP0005000_abnormal_immune_tolerance2.23181512
14MP0001800_abnormal_humoral_immune2.21972343
15MP0005387_immune_system_phenotype2.20997118
16MP0001790_abnormal_immune_system2.20997118
17MP0005671_abnormal_response_to2.18412134
18MP0005025_abnormal_response_to2.07987973
19MP0002723_abnormal_immune_serum2.06519540
20MP0001145_abnormal_male_reproductive2.04917899
21MP0005058_abnormal_lysosome_morphology1.97914066
22MP0003646_muscle_fatigue1.97513091
23MP0005310_abnormal_salivary_gland1.93529643
24MP0002419_abnormal_innate_immunity1.86062077
25MP0002452_abnormal_antigen_presenting1.85568161
26MP0000653_abnormal_sex_gland1.84946864
27MP0008057_abnormal_DNA_replication1.81517998
28MP0008260_abnormal_autophagy1.81025552
29MP0003698_abnormal_male_reproductive1.78729351
30MP0002160_abnormal_reproductive_system1.75544996
31MP0003123_paternal_imprinting1.70831297
32MP0000685_abnormal_immune_system1.66760384
33MP0004947_skin_inflammation1.66404977
34MP0001819_abnormal_immune_cell1.63243997
35MP0002420_abnormal_adaptive_immunity1.61828544
36MP0000569_abnormal_digit_pigmentation1.59154955
37MP0003300_gastrointestinal_ulcer1.57747918
38MP0005451_abnormal_body_composition1.56492326
39MP0001119_abnormal_female_reproductive1.50288418
40MP0010155_abnormal_intestine_physiology1.49611743
41MP0005389_reproductive_system_phenotype1.48633545
42MP0003763_abnormal_thymus_physiology1.43708923
43MP0009764_decreased_sensitivity_to1.40520915
44MP0001661_extended_life_span1.39825920
45MP0004808_abnormal_hematopoietic_stem1.39236147
46MP0001845_abnormal_inflammatory_respons1.37710921
47MP0003453_abnormal_keratinocyte_physiol1.36051718
48MP0008995_early_reproductive_senescence1.33087418
49MP0000383_abnormal_hair_follicle1.32719636
50MP0004510_myositis1.31975187
51MP0009333_abnormal_splenocyte_physiolog1.31601407
52MP0002139_abnormal_hepatobiliary_system1.29060916
53MP0008469_abnormal_protein_level1.28686095
54MP0000716_abnormal_immune_system1.27128322
55MP0002405_respiratory_system_inflammati1.26691500
56MP0002398_abnormal_bone_marrow1.25284087
57MP0009278_abnormal_bone_marrow1.22936560
58MP0003448_altered_tumor_morphology1.20320984
59MP0010307_abnormal_tumor_latency1.19881999
60MP0001533_abnormal_skeleton_physiology1.19521099
61MP0000015_abnormal_ear_pigmentation1.17760097
62MP0003183_abnormal_peptide_metabolism1.16745220
63MP0002332_abnormal_exercise_endurance1.10414498
64MP0001545_abnormal_hematopoietic_system1.09233654
65MP0005397_hematopoietic_system_phenotyp1.09233654
66MP0002722_abnormal_immune_system1.08343119
67MP0003693_abnormal_embryo_hatching1.04353520
68MP0010678_abnormal_skin_adnexa1.04301460
69MP0001853_heart_inflammation1.03490486
70MP0000689_abnormal_spleen_morphology1.02413072
71MP0003699_abnormal_female_reproductive0.98193331
72MP0000703_abnormal_thymus_morphology0.97209651
73MP0008007_abnormal_cellular_replicative0.95774950
74MP0002429_abnormal_blood_cell0.95523989
75MP0005410_abnormal_fertilization0.94007008
76MP0003075_altered_response_to0.93794373
77MP0005464_abnormal_platelet_physiology0.92733302
78MP0005174_abnormal_tail_pigmentation0.92674649
79MP0003172_abnormal_lysosome_physiology0.91511548
80MP0002161_abnormal_fertility/fecundity0.90444267
81MP0010352_gastrointestinal_tract_polyps0.90305927
82MP0010094_abnormal_chromosome_stability0.89958957
83MP0000678_abnormal_parathyroid_gland0.83441715
84MP0000343_altered_response_to0.80272864
85MP0002006_tumorigenesis0.80082874
86MP0005076_abnormal_cell_differentiation0.79941506
87MP0003690_abnormal_glial_cell0.79828045
88MP0001542_abnormal_bone_strength0.77592565
89MP0005666_abnormal_adipose_tissue0.77239115
90MP0005647_abnormal_sex_gland0.75898596
91MP0003656_abnormal_erythrocyte_physiolo0.74503299
92MP0000858_altered_metastatic_potential0.71990477
93MP0001919_abnormal_reproductive_system0.71265420
94MP0006035_abnormal_mitochondrial_morpho0.69490202
95MP0003195_calcinosis0.68662909
96MP0002277_abnormal_respiratory_mucosa0.68658004
97MP0003786_premature_aging0.68606696
98MP0009763_increased_sensitivity_to0.67659223
99MP0000490_abnormal_crypts_of0.67496352
100MP0000427_abnormal_hair_cycle0.65759690

Predicted human phenotypes

RankGene SetZ-score
1Shoulder girdle muscle weakness (HP:0003547)5.05802875
2Upper motor neuron abnormality (HP:0002127)4.94178224
3Amyotrophic lateral sclerosis (HP:0007354)4.88242982
4Gonadotropin excess (HP:0000837)4.64896564
5Optic neuritis (HP:0100653)4.50385872
6Retrobulbar optic neuritis (HP:0100654)4.50385872
7Volvulus (HP:0002580)4.49500790
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.40664891
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.40664891
10Orchitis (HP:0100796)4.20742237
11Rimmed vacuoles (HP:0003805)4.18233561
12Recurrent bacterial skin infections (HP:0005406)4.08078513
13Azoospermia (HP:0000027)3.84443966
14Myositis (HP:0100614)3.73147736
15Keratoconjunctivitis sicca (HP:0001097)3.64454949
16Oligodactyly (hands) (HP:0001180)3.60259179
17Disinhibition (HP:0000734)3.59134827
18Abnormality of macrophages (HP:0004311)3.57888928
19Abnormality of the lower motor neuron (HP:0002366)3.56699572
20Recurrent abscess formation (HP:0002722)3.56653122
21Stomatitis (HP:0010280)3.31106056
22Keratoconjunctivitis (HP:0001096)3.26195874
23Loss of speech (HP:0002371)3.25874115
24Horizontal nystagmus (HP:0000666)3.16187648
25Eczematoid dermatitis (HP:0000976)3.15171544
26Spontaneous abortion (HP:0005268)3.11725851
27Atrophy/Degeneration involving motor neurons (HP:0007373)3.11004978
28Mediastinal lymphadenopathy (HP:0100721)3.10830040
29Abnormality of the corticospinal tract (HP:0002492)3.10344311
30Increased IgM level (HP:0003496)3.00062244
31Abnormal spermatogenesis (HP:0008669)2.97294481
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91535681
33Vasculitis (HP:0002633)2.79252338
34Inappropriate behavior (HP:0000719)2.66868095
35Osteomalacia (HP:0002749)2.65496400
36Recurrent gram-negative bacterial infections (HP:0005420)2.53711126
37Abnormality of the vocal cords (HP:0008777)2.51340229
38Agnosia (HP:0010524)2.51011175
39Recurrent skin infections (HP:0001581)2.49870112
40Impaired vibration sensation in the lower limbs (HP:0002166)2.43902407
41Pulmonary infiltrates (HP:0002113)2.41589561
42Oligodactyly (HP:0012165)2.41282558
43Urinary bladder sphincter dysfunction (HP:0002839)2.38505939
44Elevated erythrocyte sedimentation rate (HP:0003565)2.35558421
45Progressive external ophthalmoplegia (HP:0000590)2.34022438
46Abnormality of liposaccharide metabolism (HP:0010968)2.29768039
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.29768039
48Abnormality of glycolipid metabolism (HP:0010969)2.29768039
49Resting tremor (HP:0002322)2.29438067
50Encephalitis (HP:0002383)2.29431781
51Gingivitis (HP:0000230)2.26417988
52Metaphyseal cupping (HP:0003021)2.26349766
53Urinary urgency (HP:0000012)2.25671654
54Recurrent viral infections (HP:0004429)2.25578787
55Menstrual irregularities (HP:0000858)2.25480207
56Hemoptysis (HP:0002105)2.22811328
57Abnormal protein glycosylation (HP:0012346)2.20483726
58Abnormal glycosylation (HP:0012345)2.20483726
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20483726
60Abnormal protein N-linked glycosylation (HP:0012347)2.20483726
61Recurrent fungal infections (HP:0002841)2.19793817
62Autoimmune hemolytic anemia (HP:0001890)2.19753654
63Truncal obesity (HP:0001956)2.12507596
64T lymphocytopenia (HP:0005403)2.10317637
65Abnormality of T cell number (HP:0011839)2.09849508
66Keratitis (HP:0000491)2.05498082
67Meningitis (HP:0001287)2.04553874
68Recurrent cutaneous fungal infections (HP:0011370)2.04377982
69Chronic mucocutaneous candidiasis (HP:0002728)2.04377982
70Gangrene (HP:0100758)2.04103887
71Gastrointestinal infarctions (HP:0005244)2.03186197
7211 pairs of ribs (HP:0000878)2.02896419
73Ectopic kidney (HP:0000086)2.02488299
74Abnormality of the basal ganglia (HP:0002134)2.00172822
75Tubulointerstitial nephritis (HP:0001970)1.99284926
76Autoimmune thrombocytopenia (HP:0001973)1.99143473
77Capillary hemangiomas (HP:0005306)1.97240840
78Neurodegeneration (HP:0002180)1.93993930
79Polyneuropathy (HP:0001271)1.93613188
80Limb-girdle muscle weakness (HP:0003325)1.92740828
81Type I transferrin isoform profile (HP:0003642)1.92571980
82Spastic gait (HP:0002064)1.92319732
83Abnormality of the lumbar spine (HP:0100712)1.91364736
84Abnormal delayed hypersensitivity skin test (HP:0002963)1.89699783
85Memory impairment (HP:0002354)1.87930483
86Basal ganglia calcification (HP:0002135)1.87300531
87Abnormality of the motor neurons (HP:0002450)1.87145652
88Abnormal neuron morphology (HP:0012757)1.87145652
89Chronic diarrhea (HP:0002028)1.85073249
90Hypergammaglobulinemia (HP:0010702)1.83519334
91Obstructive lung disease (HP:0006536)1.82742058
92Chronic obstructive pulmonary disease (HP:0006510)1.82742058
93Spastic paraplegia (HP:0001258)1.82164045
94Anorexia (HP:0002039)1.82074884
95Basal cell carcinoma (HP:0002671)1.80519582
96Urinary incontinence (HP:0000020)1.79083050
97Systemic lupus erythematosus (HP:0002725)1.78965635
98Glomerulopathy (HP:0100820)1.74999509
99Bulbar palsy (HP:0001283)1.74202326
100Increased nuchal translucency (HP:0010880)1.73602149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.95018091
2CDK194.09715977
3FGR3.20972828
4TYK22.53491402
5MET2.49696595
6IKBKE2.41376089
7CSF1R2.37635024
8BMX2.36807963
9CAMK1G2.26383745
10MAP3K142.21616252
11PRPF4B2.05571766
12ACVR1B2.02657245
13PTK2B2.00886766
14GRK71.92860903
15IRAK41.92592471
16MAP3K131.83922800
17JAK31.82589619
18TAOK21.80081389
19IRAK31.78073141
20TBK11.77018444
21RIPK41.63480908
22PDK21.62919090
23STK38L1.57665320
24NEK91.53984309
25RIPK11.51767597
26MAP4K11.49002973
27BLK1.43780079
28MATK1.38961193
29MOS1.38412434
30FGFR31.38005681
31PDGFRB1.28698484
32JAK11.27933548
33MAP2K31.22159168
34CSK1.18833092
35OXSR11.17768083
36TAOK11.16212568
37TXK1.15031600
38MAP3K51.11341335
39KIT1.06423527
40BMPR21.05469941
41JAK21.00625382
42IKBKB1.00227267
43CDK60.96138141
44YES10.95587562
45FGFR40.94176796
46RET0.92620710
47STK380.92476880
48PLK40.88043023
49CDK40.86395777
50EGFR0.83972325
51DYRK30.79362504
52PASK0.74574735
53BRAF0.74301144
54PIM10.72989174
55STK100.72835348
56PDK10.72642685
57KSR20.72529083
58MAP3K30.71649672
59ERN10.70777319
60MARK30.70684468
61IRAK10.70343518
62MAP3K10.67215352
63IRAK20.66071996
64ZAP700.66007571
65MAP3K90.64635881
66SYK0.63648750
67MAP3K20.62163628
68TNK20.61669934
69PLK20.61472123
70NLK0.60025591
71ARAF0.59280074
72LCK0.58848591
73PDPK10.58528104
74LYN0.57532138
75KSR10.57418835
76CDK120.56665477
77BRD40.54099585
78MELK0.52896121
79STK110.50585789
80RPS6KB10.49073381
81TYRO30.48941880
82HCK0.47744695
83ATR0.45179394
84TGFBR20.45102768
85CHEK10.43251017
86CHUK0.43123036
87DDR20.42343978
88MAPK70.41829111
89BTK0.41607810
90STK240.39684253
91SGK10.38013233
92PLK10.37824468
93TTK0.35343577
94MAPK110.34474967
95FES0.34393272
96WNK10.34040204
97ATM0.31141639
98MAP3K110.31010710
99PDGFRA0.28857310
100PRKCI0.27952977

Predicted pathways (KEGG)

RankGene SetZ-score
1RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.31003971
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.02266515
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.54877459
4Measles_Homo sapiens_hsa051622.52061717
5Osteoclast differentiation_Homo sapiens_hsa043802.51021350
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47637735
7Influenza A_Homo sapiens_hsa051642.43646961
8Leishmaniasis_Homo sapiens_hsa051402.39179511
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38320125
10Allograft rejection_Homo sapiens_hsa053302.31861195
11Herpes simplex infection_Homo sapiens_hsa051682.17479355
12Legionellosis_Homo sapiens_hsa051342.09622193
13TNF signaling pathway_Homo sapiens_hsa046682.04808638
14Graft-versus-host disease_Homo sapiens_hsa053321.96013315
15Autoimmune thyroid disease_Homo sapiens_hsa053201.94405914
16Hepatitis C_Homo sapiens_hsa051601.87426197
17African trypanosomiasis_Homo sapiens_hsa051431.76592537
18Malaria_Homo sapiens_hsa051441.75281762
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72645428
20Asthma_Homo sapiens_hsa053101.70226377
21Staphylococcus aureus infection_Homo sapiens_hsa051501.67723171
22Tuberculosis_Homo sapiens_hsa051521.64053153
23Primary immunodeficiency_Homo sapiens_hsa053401.61598080
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.59237210
25Antigen processing and presentation_Homo sapiens_hsa046121.56291217
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.55616775
27Type I diabetes mellitus_Homo sapiens_hsa049401.53683901
28Toxoplasmosis_Homo sapiens_hsa051451.53550903
29Hepatitis B_Homo sapiens_hsa051611.44711935
30B cell receptor signaling pathway_Homo sapiens_hsa046621.40578736
31Dorso-ventral axis formation_Homo sapiens_hsa043201.37390456
32Rheumatoid arthritis_Homo sapiens_hsa053231.36555807
33Homologous recombination_Homo sapiens_hsa034401.36061275
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29275720
35Mismatch repair_Homo sapiens_hsa034301.28615893
36Regulation of autophagy_Homo sapiens_hsa041401.27339039
37Chemokine signaling pathway_Homo sapiens_hsa040621.24432146
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22118723
39Pertussis_Homo sapiens_hsa051331.21569678
40T cell receptor signaling pathway_Homo sapiens_hsa046601.20298959
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19616826
42Viral myocarditis_Homo sapiens_hsa054161.18258198
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17937505
44Acute myeloid leukemia_Homo sapiens_hsa052211.16945735
45Other glycan degradation_Homo sapiens_hsa005111.12711709
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11487401
47Salmonella infection_Homo sapiens_hsa051321.08895414
48Shigellosis_Homo sapiens_hsa051311.05108386
49DNA replication_Homo sapiens_hsa030301.03767470
50Hematopoietic cell lineage_Homo sapiens_hsa046401.03451015
51Cell cycle_Homo sapiens_hsa041101.02032550
52Apoptosis_Homo sapiens_hsa042100.98529891
53Epstein-Barr virus infection_Homo sapiens_hsa051690.97055363
54Prolactin signaling pathway_Homo sapiens_hsa049170.92362147
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91696438
56Lysosome_Homo sapiens_hsa041420.90273628
57VEGF signaling pathway_Homo sapiens_hsa043700.83042911
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82816131
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.77736227
60Non-homologous end-joining_Homo sapiens_hsa034500.77102767
61HTLV-I infection_Homo sapiens_hsa051660.76601127
62Viral carcinogenesis_Homo sapiens_hsa052030.76362983
63Small cell lung cancer_Homo sapiens_hsa052220.75243181
64mTOR signaling pathway_Homo sapiens_hsa041500.75016813
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74257653
66Type II diabetes mellitus_Homo sapiens_hsa049300.71228019
67Oocyte meiosis_Homo sapiens_hsa041140.70984839
68Amoebiasis_Homo sapiens_hsa051460.68684105
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63902975
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63123973
71Chronic myeloid leukemia_Homo sapiens_hsa052200.62939344
72Pancreatic cancer_Homo sapiens_hsa052120.62376627
73RNA transport_Homo sapiens_hsa030130.62098668
74Phagosome_Homo sapiens_hsa041450.60897381
75Nucleotide excision repair_Homo sapiens_hsa034200.60276040
76Fanconi anemia pathway_Homo sapiens_hsa034600.57167137
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.55853795
78ErbB signaling pathway_Homo sapiens_hsa040120.55798549
79mRNA surveillance pathway_Homo sapiens_hsa030150.53539210
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53479868
81Fatty acid biosynthesis_Homo sapiens_hsa000610.51304647
82Prion diseases_Homo sapiens_hsa050200.50820078
83Base excision repair_Homo sapiens_hsa034100.49966828
84Prostate cancer_Homo sapiens_hsa052150.49813061
85p53 signaling pathway_Homo sapiens_hsa041150.44034252
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43972157
87Non-small cell lung cancer_Homo sapiens_hsa052230.43370831
88FoxO signaling pathway_Homo sapiens_hsa040680.41867530
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.41073134
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37134454
91MAPK signaling pathway_Homo sapiens_hsa040100.35152173
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34751471
93Basal transcription factors_Homo sapiens_hsa030220.31001088
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.29077273
95RNA degradation_Homo sapiens_hsa030180.28834253
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28556491
97N-Glycan biosynthesis_Homo sapiens_hsa005100.26959354
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26544658
99Inositol phosphate metabolism_Homo sapiens_hsa005620.26312223
100Endocytosis_Homo sapiens_hsa041440.26121118

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