HERC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to type I interferon (GO:0071357)5.93174287
2type I interferon signaling pathway (GO:0060337)5.93174287
3response to type I interferon (GO:0034340)5.92354085
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.52741981
5positive regulation of interferon-alpha production (GO:0032727)5.34123407
6response to interferon-alpha (GO:0035455)5.20141335
7regulation of interferon-alpha production (GO:0032647)5.02682612
8response to peptidoglycan (GO:0032494)4.87237980
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85325775
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85325775
11regulation of RIG-I signaling pathway (GO:0039535)4.83374214
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.79818543
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.79818543
14modulation by symbiont of host immune response (GO:0052553)4.79818543
15positive regulation by symbiont of host defense response (GO:0052509)4.79818543
16modulation by symbiont of host defense response (GO:0052031)4.79818543
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.79818543
18antigen processing and presentation of endogenous antigen (GO:0019883)4.58459652
19negative regulation of viral genome replication (GO:0045071)4.52922320
20cellular response to interferon-beta (GO:0035458)4.45731260
21neutrophil activation involved in immune response (GO:0002283)4.29975004
22T-helper 1 type immune response (GO:0042088)4.23432642
23negative regulation of interleukin-12 production (GO:0032695)4.15877255
24cellular response to exogenous dsRNA (GO:0071360)4.14745484
25regulation of chronic inflammatory response (GO:0002676)4.12027067
26regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.10606075
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.04551520
28interferon-gamma-mediated signaling pathway (GO:0060333)4.01284184
29response to interferon-beta (GO:0035456)3.98236602
30negative regulation of cell killing (GO:0031342)3.96128551
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96128551
32cellular response to interferon-alpha (GO:0035457)3.94893684
33regulation of vitamin D biosynthetic process (GO:0060556)3.88377384
34immunoglobulin mediated immune response (GO:0016064)3.84585783
35response to host immune response (GO:0052572)3.82944686
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82944686
37regulation of activation of Janus kinase activity (GO:0010533)3.79104098
38positive regulation of interferon-beta production (GO:0032728)3.77710323
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76923820
40regulation of T-helper 1 cell differentiation (GO:0045625)3.74119882
41regulation of interferon-beta biosynthetic process (GO:0045357)3.72192322
42positive regulation of toll-like receptor signaling pathway (GO:0034123)3.68971718
43regulation of viral genome replication (GO:0045069)3.67455998
44positive regulation of gamma-delta T cell activation (GO:0046645)3.66485541
45positive regulation of type 2 immune response (GO:0002830)3.64384007
46positive regulation of natural killer cell differentiation (GO:0032825)3.61212909
47defense response to virus (GO:0051607)3.60267905
48positive regulation of interleukin-17 production (GO:0032740)3.59115944
49T cell migration (GO:0072678)3.59077173
50negative regulation of viral process (GO:0048525)3.56869212
51positive regulation of antigen processing and presentation (GO:0002579)3.56066233
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.55174262
53granulocyte activation (GO:0036230)3.54647285
54cellular response to virus (GO:0098586)3.54015631
55negative regulation of T cell mediated immunity (GO:0002710)3.53854189
56neutrophil activation (GO:0042119)3.53776654
57natural killer cell mediated cytotoxicity (GO:0042267)3.51200798
58natural killer cell mediated immunity (GO:0002228)3.51200798
59macrophage activation involved in immune response (GO:0002281)3.50993191
60defense response to protozoan (GO:0042832)3.49721428
61regulation of MHC class I biosynthetic process (GO:0045343)3.48929550
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.48068051
63negative regulation of type I interferon production (GO:0032480)3.40675363
64positive regulation of interleukin-12 production (GO:0032735)3.39240902
65response to muramyl dipeptide (GO:0032495)3.33783941
66regulation of type 2 immune response (GO:0002828)3.33587906
67positive regulation of defense response to virus by host (GO:0002230)3.33394407
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32194119
69superoxide anion generation (GO:0042554)3.31637506
70negative regulation of cytokine production involved in immune response (GO:0002719)3.30373937
71respiratory burst (GO:0045730)3.29631273
72positive regulation of cellular amide metabolic process (GO:0034250)3.29530159
73microglial cell activation (GO:0001774)3.29344637
74response to host (GO:0075136)3.28775125
75response to host defenses (GO:0052200)3.28775125
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28775125
77positive regulation of response to biotic stimulus (GO:0002833)3.28680731
78positive regulation of chemokine biosynthetic process (GO:0045080)3.28381169
79positive regulation of T cell cytokine production (GO:0002726)3.26981899
80regulation of antigen processing and presentation (GO:0002577)3.26448150
81cellular response to interferon-gamma (GO:0071346)3.22933970
82NIK/NF-kappaB signaling (GO:0038061)3.20838841
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.18469517
84positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.17684848
85natural killer cell activation involved in immune response (GO:0002323)3.13735735
86regulation of chemokine biosynthetic process (GO:0045073)3.12541055
87regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12133686
88mature B cell differentiation (GO:0002335)3.11501958
89detection of other organism (GO:0098543)3.08694927
90regulation of vitamin metabolic process (GO:0030656)3.08480066
91regulation of alpha-beta T cell proliferation (GO:0046640)3.07771002
92myeloid cell activation involved in immune response (GO:0002275)3.07758423
93regulation of interleukin-17 production (GO:0032660)3.07235632
94I-kappaB phosphorylation (GO:0007252)3.06569040
95positive regulation of heat generation (GO:0031652)3.05881668
96regulation of defense response to virus by host (GO:0050691)3.05527121
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.04837704
98interferon-gamma secretion (GO:0072643)3.03353348
99myeloid dendritic cell differentiation (GO:0043011)3.02741598
100negative regulation of myeloid cell apoptotic process (GO:0033033)3.02160442
101response to protozoan (GO:0001562)3.00050373
102positive regulation of alpha-beta T cell proliferation (GO:0046641)2.99964716
103regulation of interferon-gamma biosynthetic process (GO:0045072)2.97839036
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97212583
105germinal center formation (GO:0002467)2.95910928
106positive regulation of isotype switching (GO:0045830)2.94800147
107lymphocyte chemotaxis (GO:0048247)2.94550845
108B cell mediated immunity (GO:0019724)2.94104804
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93880287
110regulation of T cell tolerance induction (GO:0002664)2.93425877
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.92380797
112monocyte chemotaxis (GO:0002548)2.91684276
113detection of molecule of bacterial origin (GO:0032490)2.91637825
114positive regulation of humoral immune response (GO:0002922)2.91623891
115regulation of gamma-delta T cell activation (GO:0046643)2.89331831
116response to interferon-gamma (GO:0034341)2.88980789
117positive regulation of cAMP-mediated signaling (GO:0043950)2.88966596
118positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.88536822
119regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.88536822
120regulation of cytokine secretion involved in immune response (GO:0002739)2.88385375
121regulation of fever generation (GO:0031620)2.86997937
122response to exogenous dsRNA (GO:0043330)2.86625361
123regulation of interferon-beta production (GO:0032648)2.86330180
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86231594
125negative regulation of interleukin-17 production (GO:0032700)2.86031774
126interferon-gamma production (GO:0032609)2.84041935
127regulation of memory T cell differentiation (GO:0043380)2.83867187
128regulation of interleukin-12 production (GO:0032655)2.83115564
129regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81802607
130regulation of T-helper cell differentiation (GO:0045622)2.81161086
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81005018
132negative regulation of multi-organism process (GO:0043901)2.80405112
133positive regulation of NF-kappaB import into nucleus (GO:0042346)2.79584452
134detection of bacterium (GO:0016045)2.79438598
135positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.78887798
136negative regulation of innate immune response (GO:0045824)2.78317608
137regulation of response to interferon-gamma (GO:0060330)2.76797189
138regulation of podosome assembly (GO:0071801)2.73626652
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73499481
140regulation of immunoglobulin secretion (GO:0051023)2.72177152
141positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.68701545
142cytokine biosynthetic process (GO:0042089)2.65916804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.16119109
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.46867725
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.46136602
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.27107443
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.57412793
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.98321198
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.75215441
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11200558
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92496213
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82979723
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78041268
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.72984489
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.50122352
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41474741
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37746232
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25493787
17GATA1_22025678_ChIP-Seq_K562_Human2.20349584
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.15091989
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06993934
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.00356590
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90865748
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90815187
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83038781
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68758061
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66088160
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64708408
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64329673
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60911845
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.60093903
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58901088
31RUNX_20019798_ChIP-Seq_JUKART_Human1.54404723
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53837192
33PU_27001747_Chip-Seq_BMDM_Mouse1.46473356
34SPI1_23547873_ChIP-Seq_NB4_Human1.42823838
35* MYB_26560356_Chip-Seq_TH2_Human1.41891858
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40736957
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39723518
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39396407
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.37233904
40EZH2_22144423_ChIP-Seq_EOC_Human1.37134778
41VDR_24787735_ChIP-Seq_THP-1_Human1.36699448
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35456547
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35112181
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31885301
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30533712
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27447827
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.27387455
48SCL_19346495_ChIP-Seq_HPC-7_Human1.26066701
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23658914
50SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23067668
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.21670610
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21285650
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.20159783
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16918556
55NMYC_18555785_Chip-Seq_ESCs_Mouse1.16725787
56P53_22387025_ChIP-Seq_ESCs_Mouse1.15536461
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15112983
58PU1_27457419_Chip-Seq_LIVER_Mouse1.15001647
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14431917
60* MYB_26560356_Chip-Seq_TH1_Human1.13786126
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10629083
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.09762045
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09328408
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.09106214
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.08798163
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.08336655
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.08104610
68P300_18555785_Chip-Seq_ESCs_Mouse1.08085569
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07622220
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07604334
71EGR1_19032775_ChIP-ChIP_M12_Human1.07127753
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.05205362
73MAF_26560356_Chip-Seq_TH1_Human1.03905648
74SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02822389
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.02529882
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02171094
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.01388797
78GATA3_26560356_Chip-Seq_TH2_Human1.00985928
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.00959772
80ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00252758
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00163739
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.00115331
83ZFX_18555785_Chip-Seq_ESCs_Mouse0.99663600
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99142781
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99142781
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99142781
87BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98231904
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97371058
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97271295
90UTX_26944678_Chip-Seq_JUKART_Human0.97159192
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96844749
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94402292
93SPI1_23127762_ChIP-Seq_K562_Human0.93722593
94KLF4_18555785_Chip-Seq_ESCs_Mouse0.92808707
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92749832
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91211736
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90715485
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.90366035
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89974079
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89427472
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89426890
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88264069
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87711076
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87547627
105SMRT_27268052_Chip-Seq_Bcells_Human0.87217747
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87135018
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87127287
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85647376
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.84840675
110SOX2_20726797_ChIP-Seq_SW620_Human0.84595622
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84233984
112GATA1_19941826_ChIP-Seq_K562_Human0.83694825
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83410059
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.83174010
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82890765
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82861641
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82700134
118VDR_24763502_ChIP-Seq_THP-1_Human0.82121984
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81470654
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.80993376
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80458438
122GATA3_27048872_Chip-Seq_THYMUS_Human0.80384502
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79314607
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78208407
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77430374
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75794185
127TP63_23658742_ChIP-Seq_EP156T_Human0.73613551
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73371563
129TCF7_22412390_ChIP-Seq_EML_Mouse0.71774164
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71620876
131MAF_26560356_Chip-Seq_TH2_Human0.71529903
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71469908
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.71416789
134ER_23166858_ChIP-Seq_MCF-7_Human0.70749794
135GBX2_23144817_ChIP-Seq_PC3_Human0.70661914
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70084255
137VDR_21846776_ChIP-Seq_THP-1_Human0.69873612
138STAT1_20625510_ChIP-Seq_HELA_Human0.69146286
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68908086
140GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68252338
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67983619
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67983619
143CJUN_26792858_Chip-Seq_BT549_Human0.65681531
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.63514091
145TFEB_21752829_ChIP-Seq_HELA_Human0.62630237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.04694005
2MP0009785_altered_susceptibility_to4.50935838
3MP0003724_increased_susceptibility_to4.27302913
4MP0002148_abnormal_hypersensitivity_rea3.51201596
5MP0001790_abnormal_immune_system3.33416115
6MP0005387_immune_system_phenotype3.33416115
7MP0003436_decreased_susceptibility_to3.19585300
8MP0005025_abnormal_response_to3.17654360
9MP0000685_abnormal_immune_system3.15690527
10MP0005000_abnormal_immune_tolerance3.13125149
11MP0005671_abnormal_response_to3.10279455
12MP0002419_abnormal_innate_immunity2.90243560
13MP0006082_CNS_inflammation2.90094130
14MP0001800_abnormal_humoral_immune2.72301405
15MP0002723_abnormal_immune_serum2.66394526
16MP0002452_abnormal_antigen_presenting2.64253797
17MP0003300_gastrointestinal_ulcer2.47042060
18MP0003303_peritoneal_inflammation2.38865792
19MP0001819_abnormal_immune_cell2.29901916
20MP0002420_abnormal_adaptive_immunity2.24886898
21MP0004510_myositis2.18815212
22MP0009764_decreased_sensitivity_to2.12564225
23MP0002006_tumorigenesis2.07768390
24MP0003136_yellow_coat_color1.95181312
25MP0002139_abnormal_hepatobiliary_system1.87747257
26MP0002166_altered_tumor_susceptibility1.85615301
27MP0002277_abnormal_respiratory_mucosa1.80863987
28MP0001533_abnormal_skeleton_physiology1.78704810
29MP0001845_abnormal_inflammatory_respons1.75724018
30MP0008469_abnormal_protein_level1.74648978
31MP0001853_heart_inflammation1.74299375
32MP0009840_abnormal_foam_cell1.72306029
33MP0010155_abnormal_intestine_physiology1.68027175
34MP0000716_abnormal_immune_system1.67306690
35MP0005464_abnormal_platelet_physiology1.66884371
36MP0004381_abnormal_hair_follicle1.64056893
37MP0002405_respiratory_system_inflammati1.62505383
38MP0004947_skin_inflammation1.60644955
39MP0005058_abnormal_lysosome_morphology1.60369515
40MP0005451_abnormal_body_composition1.59217758
41MP0005174_abnormal_tail_pigmentation1.58371871
42MP0002398_abnormal_bone_marrow1.56001848
43MP0003763_abnormal_thymus_physiology1.53488572
44MP0002332_abnormal_exercise_endurance1.52915619
45MP0000015_abnormal_ear_pigmentation1.47855471
46MP0002138_abnormal_hepatobiliary_system1.44101684
47MP0002998_abnormal_bone_remodeling1.42341594
48MP0008260_abnormal_autophagy1.41867082
49MP0005310_abnormal_salivary_gland1.40897581
50MP0003448_altered_tumor_morphology1.38523856
51MP0002429_abnormal_blood_cell1.25926296
52MP0009333_abnormal_splenocyte_physiolog1.23970158
53MP0000569_abnormal_digit_pigmentation1.23262702
54MP0005409_darkened_coat_color1.21973379
55MP0000689_abnormal_spleen_morphology1.19342820
56MP0000858_altered_metastatic_potential1.17853173
57MP0010234_abnormal_vibrissa_follicle1.17405353
58MP0003656_abnormal_erythrocyte_physiolo1.17094814
59MP0002722_abnormal_immune_system1.12791264
60MP0003075_altered_response_to1.12010826
61MP0009763_increased_sensitivity_to1.10000300
62MP0005023_abnormal_wound_healing1.09250491
63MP0003172_abnormal_lysosome_physiology1.07606186
64MP0004782_abnormal_surfactant_physiolog1.06509464
65MP0003718_maternal_effect1.06475636
66MP0009278_abnormal_bone_marrow1.06348969
67MP0005379_endocrine/exocrine_gland_phen1.05971098
68MP0001188_hyperpigmentation1.05917577
69MP0005397_hematopoietic_system_phenotyp1.05472726
70MP0001545_abnormal_hematopoietic_system1.05472726
71MP0000343_altered_response_to1.03902515
72MP0002163_abnormal_gland_morphology1.02058778
73MP0003191_abnormal_cellular_cholesterol1.00709730
74MP0005164_abnormal_response_to0.99563250
75MP0002254_reproductive_system_inflammat0.99535199
76MP0006054_spinal_hemorrhage0.95875049
77MP0000372_irregular_coat_pigmentation0.87754583
78MP0003690_abnormal_glial_cell0.86833690
79MP0005171_absent_coat_pigmentation0.86099576
80MP0001501_abnormal_sleep_pattern0.82343479
81MP0001542_abnormal_bone_strength0.82190784
82MP0003828_pulmonary_edema0.80967976
83MP0008874_decreased_physiological_sensi0.80527050
84MP0002933_joint_inflammation0.80029366
85MP0005390_skeleton_phenotype0.79391951
86MP0003879_abnormal_hair_cell0.78705069
87MP0005647_abnormal_sex_gland0.78524542
88MP0003183_abnormal_peptide_metabolism0.76698652
89MP0001873_stomach_inflammation0.75356982
90MP0005166_decreased_susceptibility_to0.74435976
91MP0000371_diluted_coat_color0.72798302
92MP0003950_abnormal_plasma_membrane0.71058349
93MP0005395_other_phenotype0.70542682
94MP0010352_gastrointestinal_tract_polyps0.69987759
95MP0003186_abnormal_redox_activity0.67786447
96MP0004808_abnormal_hematopoietic_stem0.67673475
97MP0003045_fibrosis0.67217394
98MP0000703_abnormal_thymus_morphology0.66075051
99MP0005165_increased_susceptibility_to0.65844146
100MP0001986_abnormal_taste_sensitivity0.64558759
101MP0001216_abnormal_epidermal_layer0.63884052
102MP0001851_eye_inflammation0.63082600
103MP0002095_abnormal_skin_pigmentation0.62323101
104MP0004883_abnormal_blood_vessel0.61146304
105MP0005167_abnormal_blood-brain_barrier0.61126333
106MP0003453_abnormal_keratinocyte_physiol0.60825524
107MP0010386_abnormal_urinary_bladder0.60491505
108MP0005319_abnormal_enzyme/_coenzyme0.60480311
109MP0000383_abnormal_hair_follicle0.59624986
110MP0001663_abnormal_digestive_system0.59285268
111MP0003795_abnormal_bone_structure0.59069509
112MP0001346_abnormal_lacrimal_gland0.58854730
113MP0000249_abnormal_blood_vessel0.57680099
114MP0003866_abnormal_defecation0.57048353
115MP0009765_abnormal_xenobiotic_induced0.56927300
116MP0003806_abnormal_nucleotide_metabolis0.56851070
117MP0000604_amyloidosis0.56833577
118MP0002693_abnormal_pancreas_physiology0.56625563
119MP0002876_abnormal_thyroid_physiology0.56243666
120MP0002396_abnormal_hematopoietic_system0.55553800
121MP0005075_abnormal_melanosome_morpholog0.54156259
122MP0000465_gastrointestinal_hemorrhage0.54047347
123MP0008004_abnormal_stomach_pH0.52455484
124MP0003091_abnormal_cell_migration0.51123619
125MP0003195_calcinosis0.50416554

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.67728842
2Eczematoid dermatitis (HP:0000976)5.52471395
3Recurrent bacterial skin infections (HP:0005406)5.19971402
4Increased IgM level (HP:0003496)4.66223829
5Mediastinal lymphadenopathy (HP:0100721)4.56183566
6Elevated erythrocyte sedimentation rate (HP:0003565)4.35713885
7Optic neuritis (HP:0100653)4.34015741
8Retrobulbar optic neuritis (HP:0100654)4.34015741
9Loss of speech (HP:0002371)4.32493594
10Chronic otitis media (HP:0000389)4.30407635
11Recurrent gram-negative bacterial infections (HP:0005420)4.30369800
12Orchitis (HP:0100796)4.17768517
13Myositis (HP:0100614)4.06953797
14Abnormality of macrophages (HP:0004311)3.97541539
15Abnormality of liposaccharide metabolism (HP:0010968)3.96899018
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.96899018
17Abnormality of glycolipid metabolism (HP:0010969)3.96899018
18Recurrent fungal infections (HP:0002841)3.95764180
19Vasculitis (HP:0002633)3.93066579
20Autoimmune thrombocytopenia (HP:0001973)3.88221184
21Recurrent skin infections (HP:0001581)3.87719540
22Recurrent cutaneous fungal infections (HP:0011370)3.80817513
23Chronic mucocutaneous candidiasis (HP:0002728)3.80817513
24Basal ganglia calcification (HP:0002135)3.79201146
25Recurrent viral infections (HP:0004429)3.71202071
26Stomatitis (HP:0010280)3.60712194
27Prostate neoplasm (HP:0100787)3.55767965
28Chronic obstructive pulmonary disease (HP:0006510)3.41403277
29Obstructive lung disease (HP:0006536)3.41403277
30Gingivitis (HP:0000230)3.36730649
31Hypergammaglobulinemia (HP:0010702)3.32525870
32Meningitis (HP:0001287)3.08185671
33Autoimmune hemolytic anemia (HP:0001890)3.07141019
34Vacuolated lymphocytes (HP:0001922)3.06543620
35Recurrent bronchitis (HP:0002837)3.03169536
36Pulmonary infiltrates (HP:0002113)2.96367422
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92526783
38Chronic sinusitis (HP:0011109)2.91873516
39Gingival bleeding (HP:0000225)2.89741617
40Gastrointestinal infarctions (HP:0005244)2.85209558
41Malnutrition (HP:0004395)2.84610622
42Nasal polyposis (HP:0100582)2.84222691
43Hemoptysis (HP:0002105)2.82717524
44Dysostosis multiplex (HP:0000943)2.76325775
45Recurrent pneumonia (HP:0006532)2.72520013
46Abnormality of T cell number (HP:0011839)2.70777783
47Periodontitis (HP:0000704)2.67059915
48Porencephaly (HP:0002132)2.64862909
49Thick nail (HP:0001805)2.63426438
50Agammaglobulinemia (HP:0004432)2.56893351
51Leukocytosis (HP:0001974)2.55570181
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52573570
53Hematochezia (HP:0002573)2.52436645
54Systemic lupus erythematosus (HP:0002725)2.52070719
55Eosinophilia (HP:0001880)2.51797332
56Premature loss of primary teeth (HP:0006323)2.50672116
57Abnormality of the nasal mucosa (HP:0000433)2.49868667
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48799673
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.46252312
60Keratoconjunctivitis sicca (HP:0001097)2.45000289
61T lymphocytopenia (HP:0005403)2.44471416
62Abnormality of the prostate (HP:0008775)2.44322244
63Chronic diarrhea (HP:0002028)2.42575524
64Arterial thrombosis (HP:0004420)2.42533272
65Recurrent lower respiratory tract infections (HP:0002783)2.40352996
66Osteomyelitis (HP:0002754)2.35601934
67IgG deficiency (HP:0004315)2.34704604
68Cellulitis (HP:0100658)2.34624732
69Progressive neurologic deterioration (HP:0002344)2.32190523
70Cheilitis (HP:0100825)2.31769099
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31566033
72Abnormality of polysaccharide metabolism (HP:0011012)2.31566033
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31566033
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31422310
75Abnormality of eosinophils (HP:0001879)2.29134964
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28797879
77Polyneuropathy (HP:0001271)2.28430111
78Anorexia (HP:0002039)2.28195327
79Keratoconjunctivitis (HP:0001096)2.27577867
80Joint hemorrhage (HP:0005261)2.27274111
81Increased IgE level (HP:0003212)2.25778272
82Tetraparesis (HP:0002273)2.25499333
83Abnormality of the pericardium (HP:0001697)2.25127731
84Encephalitis (HP:0002383)2.23828271
85Urticaria (HP:0001025)2.23103666
86Pustule (HP:0200039)2.22902351
87Chromsome breakage (HP:0040012)2.21514813
88Thyroiditis (HP:0100646)2.20288750
89Abnormality of the endocardium (HP:0004306)2.20208218
90Mucopolysacchariduria (HP:0008155)2.20020951
91Urinary glycosaminoglycan excretion (HP:0003541)2.20020951
92Joint swelling (HP:0001386)2.19236796
93Abnormality of T cells (HP:0002843)2.18604245
94Episodic fever (HP:0001954)2.17762234
95Apathy (HP:0000741)2.15993402
96Granulocytopenia (HP:0001913)2.14080259
97Glomerulonephritis (HP:0000099)2.12323344
98Severe combined immunodeficiency (HP:0004430)2.11332458
99Gangrene (HP:0100758)2.10694985
100Parakeratosis (HP:0001036)2.10394718
101Epistaxis (HP:0000421)2.07409700
102Diminished motivation (HP:0000745)2.07244810
103Abnormality of the basal ganglia (HP:0002134)2.07002255
104Clubbing of toes (HP:0100760)2.02457797
105Vertigo (HP:0002321)2.01485845
106Spontaneous hematomas (HP:0007420)2.00366507
107Inflammation of the large intestine (HP:0002037)2.00295054
108Conjunctival telangiectasia (HP:0000524)1.99488409
109Abnormality of B cell number (HP:0010975)1.99442618
110Disinhibition (HP:0000734)1.98546278
111Abnormality of the pleura (HP:0002103)1.97850580
112Gastrointestinal stroma tumor (HP:0100723)1.97727558
113Recurrent sinusitis (HP:0011108)1.97708119
114Keratitis (HP:0000491)1.97591205
115Pulmonary embolism (HP:0002204)1.96821138
116Interstitial pulmonary disease (HP:0006530)1.96141209
117Alveolar cell carcinoma (HP:0006519)1.96091338
118IgA deficiency (HP:0002720)1.95972708
119Abnormality of T cell physiology (HP:0011840)1.95047668
120Prolonged bleeding time (HP:0003010)1.93313213
121Nausea (HP:0002018)1.93167156
122Purpura (HP:0000979)1.92818631
123Colitis (HP:0002583)1.92386472
124Petechiae (HP:0000967)1.90850947
125Lymphopenia (HP:0001888)1.90023537
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.89974205
127Increased cerebral lipofuscin (HP:0011813)1.89560730
128Panhypogammaglobulinemia (HP:0003139)1.89417357
129Anhidrosis (HP:0000970)1.88388429
130Neurofibrillary tangles (HP:0002185)1.88204171
131Glomerulopathy (HP:0100820)1.87401810
132Myocardial infarction (HP:0001658)1.84862569
133Hepatosplenomegaly (HP:0001433)1.84404897
134Cleft eyelid (HP:0000625)1.83696975
135Combined immunodeficiency (HP:0005387)1.79762735
136Nephritis (HP:0000123)1.79712953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.55565028
2TYK23.76641816
3IKBKE3.56822077
4IRAK43.38888209
5TXK3.18004171
6IRAK33.09411600
7PBK3.03293537
8JAK32.89328299
9BLK2.77573667
10TBK12.76294715
11RIPK42.76117146
12JAK12.74974487
13MAP3K132.48831293
14KIT2.38518947
15RIPK12.36923970
16IKBKB2.25035226
17FGFR42.12806084
18MAP4K11.98250360
19EIF2AK21.85956385
20PRPF4B1.81280781
21TNIK1.68005883
22IRAK11.57706420
23TAOK21.54690628
24MAP3K31.53903111
25CASK1.52260129
26TAOK31.51439345
27CSK1.51148546
28MAP3K91.42399274
29FGFR31.41073087
30STK241.35744604
31PIM21.33451527
32NLK1.30389562
33EPHA31.30297744
34TAOK11.29774902
35CHUK1.29748743
36TEC1.25163829
37EPHB11.23378588
38BMPR21.22638381
39SYK1.19713450
40FES1.19699038
41YES11.17997470
42CDC42BPA1.16247727
43ZAP701.14437902
44LCK1.13709135
45MAP2K31.12722809
46NME21.12207826
47HCK1.11569975
48MST41.11017338
49LYN1.10137522
50DDR21.07734638
51MUSK1.07177043
52IRAK21.06710241
53NEK91.00775743
54ADRBK21.00346889
55BTK0.99956168
56SIK20.98861659
57MAP3K10.90542806
58MAP3K110.85475488
59CLK10.84836241
60STK40.81952892
61FGR0.80849001
62JAK20.79822975
63PKN10.77779269
64GRK70.77629802
65TESK20.77573063
66CSF1R0.77525711
67SIK30.76831565
68PRKCQ0.76179228
69STK160.75703885
70BMPR1B0.74645757
71PIM10.73309395
72ERN10.72861572
73NUAK10.71557172
74MARK30.69561716
75TGFBR20.67554243
76INSRR0.63962951
77CDK90.62200895
78GRK10.57428866
79KSR20.56396283
80GRK60.55847970
81MATK0.55832427
82MAPK70.55824428
83PDK10.53565118
84MAPK110.52890717
85ABL10.52347261
86TNK20.52121871
87MELK0.51711710
88MAPKAPK30.49732315
89TLK10.47203369
90PRKCD0.47077028
91RPS6KA50.46928240
92ACVR1B0.43569965
93TRPM70.43102159
94NEK60.43008560
95MAP2K60.40547257
96BRAF0.39031830
97MKNK20.38643468
98CAMKK20.37595559
99MST1R0.37257810
100ARAF0.36602899
101ITK0.34720660
102RAF10.34158849
103HIPK20.31915642
104ABL20.31633252
105PDPK10.31449940
106EGFR0.31369882
107TYRO30.31212003
108MAP3K50.30282987
109RPS6KA40.29242911
110PLK40.29167834
111PIK3CG0.28380370
112FYN0.26169860
113KSR10.25673703
114STK380.25276934
115PRKCE0.24029667
116MAP3K60.23511533
117STK100.22929919
118IGF1R0.22592451
119PRKD20.22035382
120LRRK20.21221893
121MAPK40.20915758
122BMX0.20318349
123ZAK0.19883620
124PRKCI0.19561669
125PDGFRB0.19046600
126SGK10.17758225
127TIE10.15364969
128INSR0.15325540
129SGK20.14342968
130MAPK30.13879155
131DAPK20.13873434
132MOS0.13812106
133MAPK120.13290804

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.49950387
2Graft-versus-host disease_Homo sapiens_hsa053323.41652948
3Allograft rejection_Homo sapiens_hsa053303.20998670
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.05994110
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.02245063
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.01638131
7Measles_Homo sapiens_hsa051622.98998543
8Leishmaniasis_Homo sapiens_hsa051402.90627064
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.58393268
10Staphylococcus aureus infection_Homo sapiens_hsa051502.58060593
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48595523
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.35222137
13Influenza A_Homo sapiens_hsa051642.32629060
14Primary immunodeficiency_Homo sapiens_hsa053402.23937542
15Malaria_Homo sapiens_hsa051442.21049084
16Herpes simplex infection_Homo sapiens_hsa051682.14563122
17Pertussis_Homo sapiens_hsa051332.03682246
18Osteoclast differentiation_Homo sapiens_hsa043802.01551793
19African trypanosomiasis_Homo sapiens_hsa051431.93946080
20Asthma_Homo sapiens_hsa053101.92166325
21Legionellosis_Homo sapiens_hsa051341.90783145
22Rheumatoid arthritis_Homo sapiens_hsa053231.85153035
23Autoimmune thyroid disease_Homo sapiens_hsa053201.84050814
24TNF signaling pathway_Homo sapiens_hsa046681.82850929
25Type I diabetes mellitus_Homo sapiens_hsa049401.78854108
26Tuberculosis_Homo sapiens_hsa051521.69598645
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.69099812
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.64065530
29Hematopoietic cell lineage_Homo sapiens_hsa046401.57722073
30Toxoplasmosis_Homo sapiens_hsa051451.51827134
31Hepatitis C_Homo sapiens_hsa051601.45281320
32Chemokine signaling pathway_Homo sapiens_hsa040621.35218439
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34843507
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30363812
35Antigen processing and presentation_Homo sapiens_hsa046121.27759800
36B cell receptor signaling pathway_Homo sapiens_hsa046621.24008191
37Salmonella infection_Homo sapiens_hsa051321.22688415
38Apoptosis_Homo sapiens_hsa042101.15771497
39Hepatitis B_Homo sapiens_hsa051611.13978107
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07674539
41Phagosome_Homo sapiens_hsa041450.97905770
42Other glycan degradation_Homo sapiens_hsa005110.95523740
43T cell receptor signaling pathway_Homo sapiens_hsa046600.93459354
44Caffeine metabolism_Homo sapiens_hsa002320.90071682
45Lysosome_Homo sapiens_hsa041420.84584358
46Viral myocarditis_Homo sapiens_hsa054160.81402697
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79322001
48Shigellosis_Homo sapiens_hsa051310.75891096
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73843104
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.70793922
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65170463
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64992914
53ABC transporters_Homo sapiens_hsa020100.62320028
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61594534
55Prolactin signaling pathway_Homo sapiens_hsa049170.59577708
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58678018
57VEGF signaling pathway_Homo sapiens_hsa043700.56242283
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55868327
59Complement and coagulation cascades_Homo sapiens_hsa046100.55013300
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54823746
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54554216
62Ovarian steroidogenesis_Homo sapiens_hsa049130.53852212
63Acute myeloid leukemia_Homo sapiens_hsa052210.52026545
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.46412705
65Amoebiasis_Homo sapiens_hsa051460.45495991
66Sphingolipid metabolism_Homo sapiens_hsa006000.43547905
67Insulin resistance_Homo sapiens_hsa049310.42647307
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.40943624
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38474904
70Bladder cancer_Homo sapiens_hsa052190.38063116
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37724658
72Epstein-Barr virus infection_Homo sapiens_hsa051690.36614815
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36311941
74Endocytosis_Homo sapiens_hsa041440.35916977
75Small cell lung cancer_Homo sapiens_hsa052220.35570201
76Fanconi anemia pathway_Homo sapiens_hsa034600.34766483
77Vitamin digestion and absorption_Homo sapiens_hsa049770.34422861
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34400527
79Inositol phosphate metabolism_Homo sapiens_hsa005620.34136204
80Arachidonic acid metabolism_Homo sapiens_hsa005900.33402850
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.31598779
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30902282
83Mineral absorption_Homo sapiens_hsa049780.30285758
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30090819
85Prion diseases_Homo sapiens_hsa050200.30047772
86Platelet activation_Homo sapiens_hsa046110.29151821
87Renal cell carcinoma_Homo sapiens_hsa052110.28716267
88mTOR signaling pathway_Homo sapiens_hsa041500.28039558
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27881727
90HIF-1 signaling pathway_Homo sapiens_hsa040660.27771755
91Ether lipid metabolism_Homo sapiens_hsa005650.25395801
92MAPK signaling pathway_Homo sapiens_hsa040100.24259838
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24061646
94Non-small cell lung cancer_Homo sapiens_hsa052230.23088464
95Pancreatic cancer_Homo sapiens_hsa052120.22696794
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21017265
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20574695
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20332838
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.20210435
100Viral carcinogenesis_Homo sapiens_hsa052030.19848792
101Dorso-ventral axis formation_Homo sapiens_hsa043200.19811994
102p53 signaling pathway_Homo sapiens_hsa041150.19630871
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19380503
104Sulfur metabolism_Homo sapiens_hsa009200.19191905
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.18098661
106Homologous recombination_Homo sapiens_hsa034400.17609455
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17157805
108Type II diabetes mellitus_Homo sapiens_hsa049300.15455700
109Notch signaling pathway_Homo sapiens_hsa043300.12744971
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12100066
111Steroid biosynthesis_Homo sapiens_hsa001000.11491086
112Histidine metabolism_Homo sapiens_hsa003400.11230214
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10484348
114Chronic myeloid leukemia_Homo sapiens_hsa052200.09658425
115HTLV-I infection_Homo sapiens_hsa051660.08973880
116Systemic lupus erythematosus_Homo sapiens_hsa053220.08938872
117Collecting duct acid secretion_Homo sapiens_hsa049660.08690167
118FoxO signaling pathway_Homo sapiens_hsa040680.05857638

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