HERPUD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.09913697
2L-phenylalanine catabolic process (GO:0006559)6.09913697
3L-phenylalanine metabolic process (GO:0006558)5.79064988
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.79064988
5aromatic amino acid family catabolic process (GO:0009074)5.38125791
6indole-containing compound catabolic process (GO:0042436)4.76759864
7indolalkylamine catabolic process (GO:0046218)4.76759864
8tryptophan catabolic process (GO:0006569)4.76759864
9tryptophan metabolic process (GO:0006568)4.71281422
10COPI coating of Golgi vesicle (GO:0048205)4.57097201
11Golgi transport vesicle coating (GO:0048200)4.57097201
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.48539457
13kynurenine metabolic process (GO:0070189)4.47180830
14glyoxylate metabolic process (GO:0046487)4.33095589
15sulfur amino acid catabolic process (GO:0000098)4.27648797
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.26566023
17peptidyl-glutamic acid carboxylation (GO:0017187)4.24639377
18protein carboxylation (GO:0018214)4.24639377
19cysteine metabolic process (GO:0006534)4.22194964
20high-density lipoprotein particle remodeling (GO:0034375)4.21827642
21lysine metabolic process (GO:0006553)4.21434166
22lysine catabolic process (GO:0006554)4.21434166
23bile acid biosynthetic process (GO:0006699)4.19113424
24valine metabolic process (GO:0006573)4.11887813
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.11316400
26intestinal cholesterol absorption (GO:0030299)4.03834909
27urea cycle (GO:0000050)3.97177698
28urea metabolic process (GO:0019627)3.97177698
29aromatic amino acid family metabolic process (GO:0009072)3.92542006
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.88449671
31complement activation, alternative pathway (GO:0006957)3.85354009
32signal peptide processing (GO:0006465)3.84828102
33tyrosine metabolic process (GO:0006570)3.83569987
34negative regulation of fibrinolysis (GO:0051918)3.83504574
35protein retention in ER lumen (GO:0006621)3.83082186
36homocysteine metabolic process (GO:0050667)3.82523130
37reverse cholesterol transport (GO:0043691)3.78912925
38alpha-linolenic acid metabolic process (GO:0036109)3.77949740
39regulation of triglyceride catabolic process (GO:0010896)3.72712472
40regulation of protein activation cascade (GO:2000257)3.71042131
41nitrogen cycle metabolic process (GO:0071941)3.67186754
42bile acid metabolic process (GO:0008206)3.66525740
43regulation of fibrinolysis (GO:0051917)3.64851624
44cellular modified amino acid catabolic process (GO:0042219)3.63293191
45triglyceride homeostasis (GO:0070328)3.62641899
46acylglycerol homeostasis (GO:0055090)3.62641899
47ER overload response (GO:0006983)3.61056833
48alpha-amino acid catabolic process (GO:1901606)3.59765782
49indolalkylamine metabolic process (GO:0006586)3.55395230
50amino-acid betaine metabolic process (GO:0006577)3.51467776
51coenzyme catabolic process (GO:0009109)3.50773962
52phospholipid efflux (GO:0033700)3.49842765
53cellular glucuronidation (GO:0052695)3.48746594
54regulation of complement activation (GO:0030449)3.48691929
55plasma lipoprotein particle remodeling (GO:0034369)3.46953150
56protein-lipid complex remodeling (GO:0034368)3.46953150
57macromolecular complex remodeling (GO:0034367)3.46953150
58serine family amino acid catabolic process (GO:0009071)3.46809659
59regulation of cholesterol esterification (GO:0010872)3.46597478
60drug transmembrane transport (GO:0006855)3.44168169
61cellular amino acid catabolic process (GO:0009063)3.42260794
62amine catabolic process (GO:0009310)3.41309377
63cellular biogenic amine catabolic process (GO:0042402)3.41309377
64COPII vesicle coating (GO:0048208)3.41246348
65benzene-containing compound metabolic process (GO:0042537)3.40704037
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.40235551
67bile acid and bile salt transport (GO:0015721)3.38955151
68cellular ketone body metabolic process (GO:0046950)3.33005527
69fatty acid beta-oxidation (GO:0006635)3.31901988
702-oxoglutarate metabolic process (GO:0006103)3.31666447
71complement activation, classical pathway (GO:0006958)3.29566967
72fatty acid oxidation (GO:0019395)3.27122092
73branched-chain amino acid metabolic process (GO:0009081)3.24295418
74phospholipid homeostasis (GO:0055091)3.22874169
75branched-chain amino acid catabolic process (GO:0009083)3.21379236
76regulation of cholesterol homeostasis (GO:2000188)3.20061772
77lipid oxidation (GO:0034440)3.19993689
78glucuronate metabolic process (GO:0019585)3.19628428
79uronic acid metabolic process (GO:0006063)3.19628428
80short-chain fatty acid metabolic process (GO:0046459)3.18766347
81hormone catabolic process (GO:0042447)3.17913359
82negative regulation of cholesterol transport (GO:0032375)3.17664814
83negative regulation of sterol transport (GO:0032372)3.17664814
84organic acid catabolic process (GO:0016054)3.15679348
85carboxylic acid catabolic process (GO:0046395)3.15679348
86monocarboxylic acid catabolic process (GO:0072329)3.12378738
87cholesterol efflux (GO:0033344)3.12283860
88fatty acid catabolic process (GO:0009062)3.11812995
89regulation of immunoglobulin secretion (GO:0051023)3.11610822
90complement activation (GO:0006956)3.11382095
91ethanol oxidation (GO:0006069)3.10097288
92aspartate family amino acid catabolic process (GO:0009068)3.04924458
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99484084
94glutamate metabolic process (GO:0006536)2.98981179
95cofactor catabolic process (GO:0051187)2.97750660
96pyrimidine nucleoside catabolic process (GO:0046135)2.94655469
97macroautophagy (GO:0016236)2.94627787
98protein activation cascade (GO:0072376)2.92874308
99negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.92825288
100exocrine pancreas development (GO:0031017)2.92575410
1014-hydroxyproline metabolic process (GO:0019471)2.91613965
102plasma lipoprotein particle clearance (GO:0034381)2.91594744
103low-density lipoprotein particle remodeling (GO:0034374)2.90543730
104aldehyde catabolic process (GO:0046185)2.89638621
105drug catabolic process (GO:0042737)2.89482029
106oxaloacetate metabolic process (GO:0006107)2.89299588
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88857167
108glycerophospholipid catabolic process (GO:0046475)2.86825624
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84617999
110adaptation of signaling pathway (GO:0023058)2.83140901
111antigen processing and presentation of endogenous antigen (GO:0019883)2.81760417
112positive regulation of respiratory burst (GO:0060267)2.76806763
113cellular response to antibiotic (GO:0071236)2.74290527
114cellular response to glucose starvation (GO:0042149)2.74227034
115type I interferon signaling pathway (GO:0060337)2.74159798
116cellular response to type I interferon (GO:0071357)2.74159798
117regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71601340
118response to type I interferon (GO:0034340)2.71317397
119regulation of regulatory T cell differentiation (GO:0045589)2.66162364
120cellular response to interleukin-15 (GO:0071350)2.63928768
121regulation of respiratory burst (GO:0060263)2.62144031
122regulation of B cell receptor signaling pathway (GO:0050855)2.60943086
123positive regulation of defense response to virus by host (GO:0002230)2.59003450
124regulation of autophagic vacuole assembly (GO:2000785)2.57779378
125regulation of memory T cell differentiation (GO:0043380)2.57438054
126protein K11-linked deubiquitination (GO:0035871)2.57335401
127ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.57014551
128positive regulation of interleukin-12 production (GO:0032735)2.55556384
129negative regulation of bone resorption (GO:0045779)2.54837277
130regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.54446165
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49783654
132positive regulation of protein homooligomerization (GO:0032464)2.48858856
133interferon-gamma-mediated signaling pathway (GO:0060333)2.47439340
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47260326
135* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47178137
136negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47028473
137positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46796624
138regulation of B cell apoptotic process (GO:0002902)2.46177048
139regulation of T cell mediated cytotoxicity (GO:0001914)2.45088090
140CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41408530
141* cellular response to unfolded protein (GO:0034620)2.37280249
142* endoplasmic reticulum unfolded protein response (GO:0030968)2.36772066
143negative regulation of complement activation (GO:0045916)2.36647446
144regulation of cytokine secretion involved in immune response (GO:0002739)2.36002403
145regulation of germinal center formation (GO:0002634)2.33596166
146regulation of T-helper cell differentiation (GO:0045622)2.32908911
147positive regulation of glycolytic process (GO:0045821)2.32221919
148positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.31822023
149regulation of vacuole organization (GO:0044088)2.30423971
150negative regulation of protein activation cascade (GO:2000258)2.29578693
151negative regulation of acute inflammatory response (GO:0002674)2.29134197
152regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.28649210
153intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.28070428
154negative regulation of humoral immune response (GO:0002921)2.24682848
155* positive regulation of nuclease activity (GO:0032075)2.24274750
156serine transport (GO:0032329)2.21013034
157* cellular response to topologically incorrect protein (GO:0035967)2.20402413
158positive regulation of interferon-gamma production (GO:0032729)2.18436218
159positive regulation of interleukin-17 production (GO:0032740)2.18097463
160ER to Golgi vesicle-mediated transport (GO:0006888)2.17154930
161basic amino acid transport (GO:0015802)2.16792899
162cellular response to toxic substance (GO:0097237)2.14480261
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.12715246
164cellular response to ATP (GO:0071318)2.12419590
165regulation of inflammatory response to antigenic stimulus (GO:0002861)2.12403959
166positive regulation of autophagy (GO:0010508)2.12126204
167protein targeting to Golgi (GO:0000042)2.11982282
168* regulation of nuclease activity (GO:0032069)2.11385243
169ketone body metabolic process (GO:1902224)2.11302480
170positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.11187806
171cytidine deamination (GO:0009972)2.09777111
172cytidine metabolic process (GO:0046087)2.09777111
173cytidine catabolic process (GO:0006216)2.09777111
174regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.09276027
175regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.09034499
176regulation of hexokinase activity (GO:1903299)2.08401568
177regulation of glucokinase activity (GO:0033131)2.08401568
178platelet dense granule organization (GO:0060155)2.07970652
179* ER-nucleus signaling pathway (GO:0006984)2.07822595
180phenylpropanoid metabolic process (GO:0009698)2.07734279
181zinc ion transport (GO:0006829)2.07632915
182establishment of protein localization to Golgi (GO:0072600)2.06191831
183regulation of energy homeostasis (GO:2000505)2.05116694
184interferon-gamma production (GO:0032609)2.04094717
185regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.03856424
186regulation of interferon-beta biosynthetic process (GO:0045357)2.03351852
187immunoglobulin mediated immune response (GO:0016064)2.03056480
188regulation of defense response to virus by host (GO:0050691)2.02334571
189regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.02104301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.70894805
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.41948234
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.70618472
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.16472036
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.97572387
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.26731047
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.24856812
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.77516722
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54943171
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36353166
11* IRF8_22096565_ChIP-ChIP_GC-B_Human3.11174792
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.05148989
13GATA1_22025678_ChIP-Seq_K562_Human3.00562957
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.63002787
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57123918
16* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30236231
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.12770434
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09272772
19* CLOCK_20551151_ChIP-Seq_293T_Human2.02344711
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92888960
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72869302
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71813185
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69417376
24ZNF274_21170338_ChIP-Seq_K562_Hela1.66395691
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64084102
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62562032
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57668746
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.53540122
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48404213
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45616660
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.45171343
32VDR_24787735_ChIP-Seq_THP-1_Human1.39615953
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38823750
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37097709
35* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35788656
36* MYB_26560356_Chip-Seq_TH2_Human1.34682439
37BCAT_22108803_ChIP-Seq_LS180_Human1.34019167
38CDX2_22108803_ChIP-Seq_LS180_Human1.33744998
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32033635
40* GATA3_27048872_Chip-Seq_THYMUS_Human1.30669965
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30582630
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30283902
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30247107
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29696795
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29589965
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28970189
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27316161
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24651708
49SMRT_27268052_Chip-Seq_Bcells_Human1.24100836
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23885068
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23630278
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21935816
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20336773
54* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19432566
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19412065
56GATA4_25053715_ChIP-Seq_YYC3_Human1.19397361
57ER_23166858_ChIP-Seq_MCF-7_Human1.17469243
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16700634
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14522398
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.11409883
61CJUN_26792858_Chip-Seq_BT549_Human1.09801378
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09611269
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08976066
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08687892
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08334207
66MYB_26560356_Chip-Seq_TH1_Human1.08138702
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07909057
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06858908
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.06196911
70TFEB_21752829_ChIP-Seq_HELA_Human1.05849766
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.03895829
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03180074
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03015746
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.02630523
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02616253
76* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01808448
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.01399325
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00744253
79CBP_20019798_ChIP-Seq_JUKART_Human1.00744253
80* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99212514
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98508994
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98228665
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97137160
84SOX2_20726797_ChIP-Seq_SW620_Human0.95086828
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94496969
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93710761
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93616222
88RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93399435
89IGF1R_20145208_ChIP-Seq_DFB_Human0.92796545
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92294076
91* VDR_23849224_ChIP-Seq_CD4+_Human0.92140176
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91873295
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91646253
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90698198
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90111347
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88494944
97BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88216051
98TP53_18474530_ChIP-ChIP_U2OS_Human0.87974227
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87685181
100GBX2_23144817_ChIP-Seq_PC3_Human0.87378798
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.87346246
102NANOG_19829295_ChIP-Seq_ESCs_Human0.86767770
103SOX2_19829295_ChIP-Seq_ESCs_Human0.86767770
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86594160
105* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86494898
106GATA1_19941826_ChIP-Seq_K562_Human0.85798728
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.85468455
108* TP63_23658742_ChIP-Seq_EP156T_Human0.85048850
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84956698
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84296072
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.84296072
112* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83948424
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83626532
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83626532
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83341936
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.83059860
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.83059860
118GATA2_19941826_ChIP-Seq_K562_Human0.81115082
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78795555
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78297758
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78063679
122ERG_20517297_ChIP-Seq_VCAP_Human0.77117530
123* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76968407
124RUNX_20019798_ChIP-Seq_JUKART_Human0.76692382
125IRF8_21731497_ChIP-ChIP_J774_Mouse0.76533237
126* AR_20517297_ChIP-Seq_VCAP_Human0.76079687
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.75578393
128* GATA6_25053715_ChIP-Seq_YYC3_Human0.74607245
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74329089
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73609405
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73400446
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72667149
133* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.71679060
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71359495
135HTT_18923047_ChIP-ChIP_STHdh_Human0.71340220
136GATA3_26560356_Chip-Seq_TH2_Human0.70925594
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.70722437
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70482814
139* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70373278
140SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70307988
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.70182181
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69808818
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68656138
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67021897
145* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.66883000
146SCL_19346495_ChIP-Seq_HPC-7_Human0.66514180
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.66494987
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66351849
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63635739
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62673064
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.62515177
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62228588
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.61744636
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.60503912
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.60254035
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.59053730
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58617648
158EGR1_19032775_ChIP-ChIP_M12_Human0.58605528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.34781694
2MP0005360_urolithiasis5.22131505
3MP0005365_abnormal_bile_salt5.19124801
4MP0005085_abnormal_gallbladder_physiolo4.92024358
5MP0008875_abnormal_xenobiotic_pharmacok3.76457984
6MP0003195_calcinosis3.73166600
7MP0003252_abnormal_bile_duct3.41145401
8MP0001666_abnormal_nutrient_absorption3.01860146
9MP0002138_abnormal_hepatobiliary_system2.89651905
10MP0003806_abnormal_nucleotide_metabolis2.83159110
11MP0005083_abnormal_biliary_tract2.76901462
12MP0010329_abnormal_lipoprotein_level2.59265559
13MP0003191_abnormal_cellular_cholesterol2.34951561
14MP0005332_abnormal_amino_acid2.34240172
15MP0009840_abnormal_foam_cell2.22831967
16MP0005671_abnormal_response_to2.22520376
17MP0002148_abnormal_hypersensitivity_rea2.16503329
18MP0003011_delayed_dark_adaptation2.10642258
19MP0005220_abnormal_exocrine_pancreas2.07945667
20MP0005000_abnormal_immune_tolerance2.07280067
21MP0002877_abnormal_melanocyte_morpholog2.03277430
22MP0003950_abnormal_plasma_membrane2.02574011
23MP0004043_abnormal_pH_regulation2.01263351
24MP0003868_abnormal_feces_composition1.92300367
25MP0000609_abnormal_liver_physiology1.89094570
26MP0009643_abnormal_urine_homeostasis1.87457077
27MP0002163_abnormal_gland_morphology1.85389496
28MP0002118_abnormal_lipid_homeostasis1.80594173
29MP0002723_abnormal_immune_serum1.73466723
30MP0002452_abnormal_antigen_presenting1.70047288
31MP0005319_abnormal_enzyme/_coenzyme1.69369264
32MP0004019_abnormal_vitamin_homeostasis1.68052660
33MP0001764_abnormal_homeostasis1.64938636
34MP0001986_abnormal_taste_sensitivity1.63992915
35MP0001501_abnormal_sleep_pattern1.58704911
36MP0003045_fibrosis1.57795828
37MP0002693_abnormal_pancreas_physiology1.54806629
38MP0003763_abnormal_thymus_physiology1.47983412
39MP0002006_tumorigenesis1.42731932
40MP0002420_abnormal_adaptive_immunity1.41409049
41MP0001819_abnormal_immune_cell1.39227022
42MP0008872_abnormal_physiological_respon1.37870768
43MP0005084_abnormal_gallbladder_morpholo1.37093902
44MP0001944_abnormal_pancreas_morphology1.36060297
45MP0002876_abnormal_thyroid_physiology1.36017905
46MP0002837_dystrophic_cardiac_calcinosis1.35783486
47MP0004782_abnormal_surfactant_physiolog1.33838085
48MP0002078_abnormal_glucose_homeostasis1.33016558
49MP0003186_abnormal_redox_activity1.32706613
50MP0005636_abnormal_mineral_homeostasis1.29139701
51MP0002928_abnormal_bile_duct1.28568310
52MP0003183_abnormal_peptide_metabolism1.24069477
53MP0002405_respiratory_system_inflammati1.22989227
54MP0005670_abnormal_white_adipose1.22519010
55MP0003300_gastrointestinal_ulcer1.20730726
56MP0001835_abnormal_antigen_presentation1.20544923
57MP0005584_abnormal_enzyme/coenzyme_acti1.20539860
58MP0003303_peritoneal_inflammation1.19687587
59MP0003656_abnormal_erythrocyte_physiolo1.19192257
60MP0004264_abnormal_extraembryonic_tissu1.18775334
61MP0005058_abnormal_lysosome_morphology1.17497839
62MP0009697_abnormal_copulation1.16840618
63MP0005645_abnormal_hypothalamus_physiol1.16447805
64MP0005164_abnormal_response_to1.16201547
65MP0000372_irregular_coat_pigmentation1.16095470
66MP0003436_decreased_susceptibility_to1.13922304
67MP0008469_abnormal_protein_level1.12001078
68MP0001756_abnormal_urination1.10897682
69MP0002933_joint_inflammation1.09759041
70MP0009764_decreased_sensitivity_to1.07867305
71MP0000598_abnormal_liver_morphology1.06397658
72MP0005551_abnormal_eye_electrophysiolog1.05996676
73MP0000716_abnormal_immune_system1.00506384
74MP0002102_abnormal_ear_morphology0.98806810
75MP0001765_abnormal_ion_homeostasis0.98378291
76MP0009780_abnormal_chondrocyte_physiolo0.96322056
77MP0009642_abnormal_blood_homeostasis0.96213681
78MP0010386_abnormal_urinary_bladder0.96052400
79MP0003724_increased_susceptibility_to0.95226286
80MP0005647_abnormal_sex_gland0.93290773
81MP0006036_abnormal_mitochondrial_physio0.92148909
82MP0002254_reproductive_system_inflammat0.92121360
83MP0001542_abnormal_bone_strength0.92103636
84MP0005408_hypopigmentation0.90991653
85MP0000569_abnormal_digit_pigmentation0.90448395
86MP0005535_abnormal_body_temperature0.89956518
87MP0003866_abnormal_defecation0.89463748
88MP0000015_abnormal_ear_pigmentation0.89066463
89MP0002136_abnormal_kidney_physiology0.88687055
90MP0001845_abnormal_inflammatory_respons0.88380831
91MP0000604_amyloidosis0.87773427
92MP0000689_abnormal_spleen_morphology0.87014532
93MP0006072_abnormal_retinal_apoptosis0.86365164
94MP0009763_increased_sensitivity_to0.85283428
95MP0002398_abnormal_bone_marrow0.84664499
96MP0000465_gastrointestinal_hemorrhage0.84300566
97MP0005451_abnormal_body_composition0.83718237
98MP0002332_abnormal_exercise_endurance0.82593493
99MP0002295_abnormal_pulmonary_circulatio0.82522060
100MP0005334_abnormal_fat_pad0.82328171
101MP0010368_abnormal_lymphatic_system0.81507347
102MP0005464_abnormal_platelet_physiology0.79826174
103MP0004947_skin_inflammation0.78645615
104MP0004883_abnormal_blood_vessel0.78218688
105MP0009765_abnormal_xenobiotic_induced0.78012327
106MP0000013_abnormal_adipose_tissue0.77397294
107MP0002090_abnormal_vision0.76325153
108MP0003953_abnormal_hormone_level0.75390290
109MP0002909_abnormal_adrenal_gland0.74349448
110MP0005387_immune_system_phenotype0.72709908
111MP0001790_abnormal_immune_system0.72709908
112MP0005310_abnormal_salivary_gland0.72168110
113MP0002166_altered_tumor_susceptibility0.71910575
114MP0000230_abnormal_systemic_arterial0.70554256
115MP0009785_altered_susceptibility_to0.70381372
116MP0002419_abnormal_innate_immunity0.69452111
117MP0005376_homeostasis/metabolism_phenot0.68728378
118MP0005448_abnormal_energy_balance0.67857812
119MP0001853_heart_inflammation0.67550473
120MP0000678_abnormal_parathyroid_gland0.63942224
121MP0006054_spinal_hemorrhage0.60890822
122MP0005025_abnormal_response_to0.60589305
123MP0001533_abnormal_skeleton_physiology0.60251593
124MP0010155_abnormal_intestine_physiology0.58969393
125MP0003959_abnormal_lean_body0.58027343
126MP0000538_abnormal_urinary_bladder0.57935022
127MP0003638_abnormal_response/metabolism_0.57883190
128MP0003172_abnormal_lysosome_physiology0.57593034
129MP0005379_endocrine/exocrine_gland_phen0.57585834
130MP0006082_CNS_inflammation0.57400879
131MP0000003_abnormal_adipose_tissue0.57273806
132MP0000613_abnormal_salivary_gland0.57217530
133MP0002896_abnormal_bone_mineralization0.56201914
134MP0000685_abnormal_immune_system0.54533786
135MP0001873_stomach_inflammation0.54270846
136MP0010234_abnormal_vibrissa_follicle0.53508625
137MP0002168_other_aberrant_phenotype0.53343026
138MP0001800_abnormal_humoral_immune0.52885638
139MP0003075_altered_response_to0.52145521

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.93026379
2Hypoglycemic coma (HP:0001325)5.06547537
3Intrahepatic cholestasis (HP:0001406)4.97089335
4Prolonged partial thromboplastin time (HP:0003645)4.73397753
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.70029081
6Deep venous thrombosis (HP:0002625)4.43588888
7Xanthomatosis (HP:0000991)4.32528946
8Abnormality of the intrinsic pathway (HP:0010989)4.32188393
9Ketosis (HP:0001946)4.24422469
10Hypoglycemic seizures (HP:0002173)4.03892190
11Ketoacidosis (HP:0001993)4.02480119
12Abnormality of the common coagulation pathway (HP:0010990)3.95643277
13Complement deficiency (HP:0004431)3.89666100
14Generalized aminoaciduria (HP:0002909)3.83934026
15Hyperinsulinemic hypoglycemia (HP:0000825)3.76093601
16Hypobetalipoproteinemia (HP:0003563)3.74031670
17Abnormality of fatty-acid metabolism (HP:0004359)3.63452784
18Fat malabsorption (HP:0002630)3.61398154
19Gout (HP:0001997)3.57637147
20Joint hemorrhage (HP:0005261)3.57605695
21Conjugated hyperbilirubinemia (HP:0002908)3.47278606
22Chronic diarrhea (HP:0002028)3.45079067
23Hyperammonemia (HP:0001987)3.40633644
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38659099
25Hyperlipoproteinemia (HP:0010980)3.38306274
26Hyperglycinuria (HP:0003108)3.28795602
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28647862
28Symptomatic seizures (HP:0011145)3.23162742
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.13951869
30Abnormality of purine metabolism (HP:0004352)3.11277965
31Metaphyseal dysplasia (HP:0100255)3.08020910
32Late onset (HP:0003584)3.03046030
33Hypolipoproteinemia (HP:0010981)3.01308710
34Chronic hepatic failure (HP:0100626)3.00703437
35Hyperglycemia (HP:0003074)2.98487803
36Abnormality of complement system (HP:0005339)2.95033680
37Hyperglycinemia (HP:0002154)2.94246379
38Abnormality of serine family amino acid metabolism (HP:0010894)2.93399606
39Abnormality of glycine metabolism (HP:0010895)2.93399606
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91352572
41Recurrent bronchitis (HP:0002837)2.91171579
42Steatorrhea (HP:0002570)2.89795998
43Hyperbilirubinemia (HP:0002904)2.89734035
44Hypoalphalipoproteinemia (HP:0003233)2.83416206
45Epidermoid cyst (HP:0200040)2.82231860
46Abnormality of methionine metabolism (HP:0010901)2.79172862
47Abnormality of nucleobase metabolism (HP:0010932)2.77784088
48Hypothermia (HP:0002045)2.76349469
49Systemic lupus erythematosus (HP:0002725)2.75614656
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72160259
51Gastrointestinal stroma tumor (HP:0100723)2.71473174
52Albinism (HP:0001022)2.63736406
53Myocardial infarction (HP:0001658)2.61612205
54Abnormality of the pancreatic islet cells (HP:0006476)2.60846657
55Abnormality of endocrine pancreas physiology (HP:0012093)2.60846657
56Pulmonary infiltrates (HP:0002113)2.60119216
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58149379
58Dicarboxylic aciduria (HP:0003215)2.58149379
59Decreased circulating renin level (HP:0003351)2.56144357
60Vasculitis (HP:0002633)2.55881289
61Metabolic acidosis (HP:0001942)2.53442091
62Abnormality of glycolipid metabolism (HP:0010969)2.52860118
63Abnormality of liposaccharide metabolism (HP:0010968)2.52860118
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.52860118
65IgG deficiency (HP:0004315)2.50612292
66Malnutrition (HP:0004395)2.48639231
67Abnormal albumin level (HP:0012116)2.48149483
68Hypoalbuminemia (HP:0003073)2.48149483
69Thyroiditis (HP:0100646)2.47997671
70Agammaglobulinemia (HP:0004432)2.47848067
71Pancreatitis (HP:0001733)2.47352117
72Proximal tubulopathy (HP:0000114)2.45802254
73Recurrent sinusitis (HP:0011108)2.44708139
74Stomatitis (HP:0010280)2.43537258
75Exocrine pancreatic insufficiency (HP:0001738)2.41377105
76Vascular calcification (HP:0004934)2.41152830
77Large for gestational age (HP:0001520)2.40913165
78Hypoplasia of the odontoid process (HP:0003311)2.39285519
79Hepatocellular carcinoma (HP:0001402)2.31217505
80Methylmalonic aciduria (HP:0012120)2.29330963
81Glomerulonephritis (HP:0000099)2.28672684
82Hypokalemic alkalosis (HP:0001949)2.28285182
83Recurrent gram-negative bacterial infections (HP:0005420)2.26895012
84Barrel-shaped chest (HP:0001552)2.26343842
85Vacuolated lymphocytes (HP:0001922)2.26172263
86Glycosuria (HP:0003076)2.23725754
87Abnormality of urine glucose concentration (HP:0011016)2.23725754
88Increased purine levels (HP:0004368)2.20729956
89Hyperuricemia (HP:0002149)2.20729956
90Enlarged kidneys (HP:0000105)2.20247478
91Abnormality of T cell physiology (HP:0011840)2.19707673
92Mitral stenosis (HP:0001718)2.16596324
93Skin nodule (HP:0200036)2.16311503
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.15516580
95Hypercholesterolemia (HP:0003124)2.14700776
96Acute hepatic failure (HP:0006554)2.14620447
97Pancreatic islet-cell hyperplasia (HP:0004510)2.13120803
98Abnormality of vitamin B metabolism (HP:0004340)2.11815582
99Abnormality of proline metabolism (HP:0010907)2.11430088
100Hydroxyprolinuria (HP:0003080)2.11430088
101Cardiovascular calcification (HP:0011915)2.11397567
102Optic neuritis (HP:0100653)2.11392882
103Retrobulbar optic neuritis (HP:0100654)2.11392882
104Abnormal tarsal ossification (HP:0008369)2.11380220
105Abnormal gallbladder morphology (HP:0012437)2.11231448
106Fetal akinesia sequence (HP:0001989)2.10884298
107Abnormality of pyrimidine metabolism (HP:0004353)2.10796334
108Hyperactive renin-angiotensin system (HP:0000841)2.10002029
109Tetraparesis (HP:0002273)2.09675099
110Hand muscle atrophy (HP:0009130)2.09126906
111Opisthotonus (HP:0002179)2.08663088
112Recurrent cutaneous fungal infections (HP:0011370)2.08542831
113Chronic mucocutaneous candidiasis (HP:0002728)2.08542831
114Abnormality of serum amino acid levels (HP:0003112)2.08466818
115Upper limb muscle weakness (HP:0003484)2.08432007
116Lethargy (HP:0001254)2.08332197
117Alkalosis (HP:0001948)2.08030214
118IgA deficiency (HP:0002720)2.06156459
119Protuberant abdomen (HP:0001538)2.06071452
120Hemoptysis (HP:0002105)2.06055863
121Urinary glycosaminoglycan excretion (HP:0003541)2.04008500
122Mucopolysacchariduria (HP:0008155)2.04008500
123Congenital sensorineural hearing impairment (HP:0008527)2.03602393
124Emphysema (HP:0002097)2.02403214
125Abnormal enzyme/coenzyme activity (HP:0012379)2.02175931
126Lymphopenia (HP:0001888)2.01942023
127Aplasia of the musculature (HP:0100854)2.00349921
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.99245276
129Abnormal pancreas size (HP:0012094)1.98958200
130Menorrhagia (HP:0000132)1.98325802
131Autoimmune hemolytic anemia (HP:0001890)1.97976166
132Renal cortical cysts (HP:0000803)1.97771483
133Chronic sinusitis (HP:0011109)1.97698704
134Vomiting (HP:0002013)1.97271508
135Increased CSF protein (HP:0002922)1.97039282
136Elevated alkaline phosphatase (HP:0003155)1.93159489
137Elevated erythrocyte sedimentation rate (HP:0003565)1.92945325
138Meningitis (HP:0001287)1.92517531
139Bronchitis (HP:0012387)1.91690748
140Follicular hyperkeratosis (HP:0007502)1.90624883
141Hematochezia (HP:0002573)1.89590663
142Elevated hepatic transaminases (HP:0002910)1.89092245
143Carpal bone hypoplasia (HP:0001498)1.88933436
144Abnormality of alkaline phosphatase activity (HP:0004379)1.88821228
145Lower limb hyperreflexia (HP:0002395)1.87471352
146Cerebral edema (HP:0002181)1.87005129
147Irritability (HP:0000737)1.87000229
148Myoglobinuria (HP:0002913)1.86708827
149Insulin resistance (HP:0000855)1.86090110
150Abnormal foot bone ossification (HP:0010675)1.84315319
151Orchitis (HP:0100796)1.83567211
152Abnormality of polysaccharide metabolism (HP:0011012)1.83087946
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83087946
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83087946
155Dysostosis multiplex (HP:0000943)1.82754139
156Reduced antithrombin III activity (HP:0001976)1.82476052
157Delayed CNS myelination (HP:0002188)1.82399086
158Hemiparesis (HP:0001269)1.81766586
159Abnormality of renin-angiotensin system (HP:0000847)1.81430076
160Keratoconjunctivitis (HP:0001096)1.81397289
161Keratitis (HP:0000491)1.81296997
162Skin rash (HP:0000988)1.81287557
163Abnormality of the pleura (HP:0002103)1.79153537
164Global brain atrophy (HP:0002283)1.78713483
165Tongue fasciculations (HP:0001308)1.77627244
166Hip dysplasia (HP:0001385)1.74148451
167Abnormality of the prostate (HP:0008775)1.73690905
168Abnormality of the vitamin B12 metabolism (HP:0004341)1.72515524
169Methylmalonic acidemia (HP:0002912)1.71714294
170Neutropenia (HP:0001875)1.71651141
171Nonprogressive disorder (HP:0003680)1.70849481
172Popliteal pterygium (HP:0009756)1.67439508
173Abnormal rod and cone electroretinograms (HP:0008323)1.65682616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.64267261
2BCKDK4.94117775
3INSRR3.90248215
4TAOK33.28036620
5FRK2.98896220
6IRAK32.72114502
7MAP3K142.63584650
8MAPK152.53583410
9FLT32.43968003
10PIK3CG2.36559753
11SIK32.06217368
12FGFR42.00882044
13SIK11.96240041
14MUSK1.90129527
15MAP3K121.81215613
16MAP4K21.79603895
17MAP3K31.79215757
18TBK11.67246670
19OXSR11.66570829
20PAK31.66098516
21TYK21.66007059
22FER1.65390969
23AKT31.63345620
24IKBKE1.45512546
25TGFBR21.44857000
26TRIB31.40207767
27MAP3K131.39766665
28IRAK41.33740820
29EPHA31.31835309
30NEK91.31292407
31JAK11.29142251
32PDK21.28860082
33PKN21.28517148
34ACVR1B1.26276842
35WNK41.23836442
36STK391.23742125
37EIF2AK31.18384542
38ADRBK21.14241546
39ZAP701.12260781
40PASK1.10674609
41MST1R1.04489502
42IKBKB1.02396540
43MAP3K21.01827086
44RIPK11.00715204
45PTK60.98568422
46JAK30.97860576
47CHUK0.96688137
48MAP2K20.96497947
49MAP2K30.96355798
50RIPK40.94017060
51STK38L0.92889203
52PRKD20.92754328
53IRAK10.92062239
54PIM20.91670466
55HIPK20.90871508
56SGK20.89907665
57JAK20.89021283
58MYLK0.86797029
59PRKCE0.85629006
60MAP3K100.85280988
61NLK0.85181431
62MAP4K10.84139947
63SGK30.80847969
64TIE10.80753607
65BMPR1B0.79505019
66MAPK110.78853405
67PRKAA20.74385884
68MAPKAPK30.72434230
69PIK3CA0.69433244
70GRK70.69367832
71FGFR30.66718874
72BTK0.64406924
73ERBB40.64394244
74FES0.64245420
75MAPK70.64111356
76LIMK10.63570359
77CSF1R0.63228217
78PDK10.61707642
79WNK30.61215324
80PHKG20.61086094
81PHKG10.61086094
82ARAF0.60876408
83BCR0.60695598
84PRKCI0.59791419
85PTK2B0.59059211
86SIK20.58727272
87TEC0.58283881
88DYRK1B0.56860084
89ITK0.56370647
90RPS6KA20.56291746
91BMPR20.55060739
92PRKG20.54710995
93ABL10.54115827
94GRK60.54083159
95HCK0.53355496
96KIT0.52192249
97TNK20.51254209
98BRSK20.50539128
99RAF10.50365277
100PINK10.48936510
101ERBB30.46829659
102PRKAA10.46807003
103CDC42BPA0.46547883
104MAP3K10.46512538
105MAP3K50.45485283
106CSK0.43955944
107SGK2230.43392156
108SGK4940.43392156
109SYK0.42434122
110RPS6KA60.42098898
111TTN0.41485629
112GSK3A0.41071736
113LATS10.40750386
114NUAK10.40102131
115LCK0.39811372
116EPHB10.39507769
117ZAK0.39085629
118MAPK120.38466870
119RPS6KC10.38383740
120RPS6KL10.38383740
121MST40.38296407
122PRKCH0.38099441
123RPS6KA50.38043216
124TXK0.36157827
125BLK0.35137930
126MARK30.34724936
127RPS6KB10.34603878
128GRK10.34584670
129IGF1R0.34577065
130PRKCD0.33541021
131TLK10.33459025
132LYN0.32259268
133MAP3K70.32198066
134PRKACG0.31538045
135MAP2K10.30129891
136MAPKAPK20.29876003
137IRAK20.29720707
138PRKCQ0.29701001
139STK240.29333099
140PDPK10.28981906
141TRPM70.28877191
142RPS6KA40.28571507

Predicted pathways (KEGG)

RankGene SetZ-score
1Type I diabetes mellitus_Homo sapiens_hsa049403.52764788
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.51694654
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.38722809
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10892218
5Allograft rejection_Homo sapiens_hsa053302.99676915
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96083022
7Autoimmune thyroid disease_Homo sapiens_hsa053202.84591044
8Asthma_Homo sapiens_hsa053102.81140249
9Graft-versus-host disease_Homo sapiens_hsa053322.74213959
10Tryptophan metabolism_Homo sapiens_hsa003802.64170984
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56850060
12Fatty acid degradation_Homo sapiens_hsa000712.54881852
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52319491
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48797512
15Sulfur metabolism_Homo sapiens_hsa009202.47896361
16Protein export_Homo sapiens_hsa030602.39538065
17Arginine biosynthesis_Homo sapiens_hsa002202.24561765
18Complement and coagulation cascades_Homo sapiens_hsa046102.16264236
19Primary immunodeficiency_Homo sapiens_hsa053402.08011691
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03029672
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00496913
22Propanoate metabolism_Homo sapiens_hsa006401.99227331
23Nitrogen metabolism_Homo sapiens_hsa009101.97294555
24Peroxisome_Homo sapiens_hsa041461.97216602
25Selenocompound metabolism_Homo sapiens_hsa004501.87277171
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86141397
27Butanoate metabolism_Homo sapiens_hsa006501.84189744
28Rheumatoid arthritis_Homo sapiens_hsa053231.81931245
29Starch and sucrose metabolism_Homo sapiens_hsa005001.77739808
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75865641
31Chemical carcinogenesis_Homo sapiens_hsa052041.68653154
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65780213
33Histidine metabolism_Homo sapiens_hsa003401.64334804
34Folate biosynthesis_Homo sapiens_hsa007901.62253627
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.61943122
36beta-Alanine metabolism_Homo sapiens_hsa004101.59892005
37Fatty acid metabolism_Homo sapiens_hsa012121.59332303
38PPAR signaling pathway_Homo sapiens_hsa033201.54194831
39Phenylalanine metabolism_Homo sapiens_hsa003601.49378103
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49065226
41Staphylococcus aureus infection_Homo sapiens_hsa051501.48740436
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.47792062
43* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42480937
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39021416
45Caffeine metabolism_Homo sapiens_hsa002321.37304468
46Fat digestion and absorption_Homo sapiens_hsa049751.37222470
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35086998
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34936509
49ABC transporters_Homo sapiens_hsa020101.30148779
50Retinol metabolism_Homo sapiens_hsa008301.26957149
51Pyruvate metabolism_Homo sapiens_hsa006201.23198109
52Tyrosine metabolism_Homo sapiens_hsa003501.20154833
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19316219
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16920872
55Mineral absorption_Homo sapiens_hsa049781.15980651
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14921926
57Viral myocarditis_Homo sapiens_hsa054161.05616974
58Bile secretion_Homo sapiens_hsa049761.05214772
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03725294
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01429374
61Sphingolipid metabolism_Homo sapiens_hsa006001.00264664
62Fatty acid elongation_Homo sapiens_hsa000620.99226035
63Arginine and proline metabolism_Homo sapiens_hsa003300.94257700
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93546288
65Hematopoietic cell lineage_Homo sapiens_hsa046400.93165384
66Influenza A_Homo sapiens_hsa051640.93093622
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92889812
68Leishmaniasis_Homo sapiens_hsa051400.91947037
69Carbon metabolism_Homo sapiens_hsa012000.91694265
70Vitamin digestion and absorption_Homo sapiens_hsa049770.89526918
71Measles_Homo sapiens_hsa051620.89085544
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.89052727
73Tuberculosis_Homo sapiens_hsa051520.88445576
74Collecting duct acid secretion_Homo sapiens_hsa049660.85688797
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.84912144
76Sulfur relay system_Homo sapiens_hsa041220.82801262
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82659198
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81956244
79Other glycan degradation_Homo sapiens_hsa005110.81467340
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78381936
81Lysine degradation_Homo sapiens_hsa003100.75855888
82TNF signaling pathway_Homo sapiens_hsa046680.75303070
83Biosynthesis of amino acids_Homo sapiens_hsa012300.74076037
84Herpes simplex infection_Homo sapiens_hsa051680.72917318
85Galactose metabolism_Homo sapiens_hsa000520.72455355
86Phototransduction_Homo sapiens_hsa047440.71539362
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70991319
88Insulin resistance_Homo sapiens_hsa049310.70382428
89Ether lipid metabolism_Homo sapiens_hsa005650.69100586
90Glycerolipid metabolism_Homo sapiens_hsa005610.67506067
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.67076827
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66365166
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65399750
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64317120
95N-Glycan biosynthesis_Homo sapiens_hsa005100.64188940
96Pertussis_Homo sapiens_hsa051330.64138422
97Dorso-ventral axis formation_Homo sapiens_hsa043200.64115390
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62796904
99Toxoplasmosis_Homo sapiens_hsa051450.58948555
100Fructose and mannose metabolism_Homo sapiens_hsa000510.58289389
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58254449
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57731096
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.56070343
104Osteoclast differentiation_Homo sapiens_hsa043800.54723277
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52977983
106Glutathione metabolism_Homo sapiens_hsa004800.52290229
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51352544
108Phagosome_Homo sapiens_hsa041450.51136973
109Steroid biosynthesis_Homo sapiens_hsa001000.50021350
110B cell receptor signaling pathway_Homo sapiens_hsa046620.49719714
111One carbon pool by folate_Homo sapiens_hsa006700.49248419
112Arachidonic acid metabolism_Homo sapiens_hsa005900.49191675
113Insulin secretion_Homo sapiens_hsa049110.47477977
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46978091
115Protein digestion and absorption_Homo sapiens_hsa049740.46875185
116Lysosome_Homo sapiens_hsa041420.46861475
117Metabolic pathways_Homo sapiens_hsa011000.44578111
118Prion diseases_Homo sapiens_hsa050200.43816711
119African trypanosomiasis_Homo sapiens_hsa051430.41418013
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.40078910
121Legionellosis_Homo sapiens_hsa051340.39902635
122T cell receptor signaling pathway_Homo sapiens_hsa046600.38450259
123Pancreatic secretion_Homo sapiens_hsa049720.34205676
124Vitamin B6 metabolism_Homo sapiens_hsa007500.33312570
125Pentose phosphate pathway_Homo sapiens_hsa000300.31170390
126Glucagon signaling pathway_Homo sapiens_hsa049220.26694390
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24136581
128Regulation of autophagy_Homo sapiens_hsa041400.23636826
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22340421
130Antigen processing and presentation_Homo sapiens_hsa046120.19857918
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17814331
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.17746075
133Thyroid hormone synthesis_Homo sapiens_hsa049180.17539498
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17023025
135Type II diabetes mellitus_Homo sapiens_hsa049300.16887728
136Linoleic acid metabolism_Homo sapiens_hsa005910.16483894
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16249343
138Renin-angiotensin system_Homo sapiens_hsa046140.15135347
139Vibrio cholerae infection_Homo sapiens_hsa051100.14930002
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.11476790
141Circadian rhythm_Homo sapiens_hsa047100.10754160
142Hepatitis C_Homo sapiens_hsa051600.10393125

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