HES1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.57280253
2ribosomal small subunit biogenesis (GO:0042274)7.31573073
3translational termination (GO:0006415)7.24664665
4ribosomal small subunit assembly (GO:0000028)6.90961833
5lymph vessel development (GO:0001945)6.65253218
6maturation of SSU-rRNA (GO:0030490)6.37098497
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.79132483
8cotranslational protein targeting to membrane (GO:0006613)5.74290208
9protein targeting to ER (GO:0045047)5.71218142
10translational elongation (GO:0006414)5.52847526
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.44003484
12cellular protein complex disassembly (GO:0043624)5.36797458
13viral life cycle (GO:0019058)5.34321834
14establishment of protein localization to mitochondrial membrane (GO:0090151)5.33261577
15otic vesicle formation (GO:0030916)5.29971771
16protein localization to endoplasmic reticulum (GO:0070972)5.25179953
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.15744059
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.07595857
19tongue development (GO:0043586)4.96232064
20response to gravity (GO:0009629)4.93358126
21negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.66092498
22somite development (GO:0061053)4.54160431
23axon ensheathment in central nervous system (GO:0032291)4.52797970
24central nervous system myelination (GO:0022010)4.52797970
25protein complex disassembly (GO:0043241)4.48193027
26glomerular filtration (GO:0003094)4.44950344
27negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.42683902
28endothelium development (GO:0003158)4.41427678
29* neuronal stem cell maintenance (GO:0097150)4.36834375
30translational initiation (GO:0006413)4.29949999
31cell proliferation involved in metanephros development (GO:0072203)4.25493498
32negative regulation of inclusion body assembly (GO:0090084)4.24240963
33regulation of mesenchymal cell apoptotic process (GO:2001053)4.19778984
34ribosomal large subunit biogenesis (GO:0042273)4.11071050
35macromolecular complex disassembly (GO:0032984)4.06961709
36negative regulation of axon guidance (GO:1902668)4.05715610
37epithelial cilium movement (GO:0003351)4.01606127
38forebrain neuron differentiation (GO:0021879)4.00990365
39renal filtration (GO:0097205)3.97367220
40keratinocyte proliferation (GO:0043616)3.94014268
41cell proliferation in forebrain (GO:0021846)3.91489074
42desmosome organization (GO:0002934)3.88116744
43glomerular basement membrane development (GO:0032836)3.87619344
44* neural crest cell development (GO:0014032)3.85481319
45spermatid nucleus differentiation (GO:0007289)3.84121421
46* mesenchymal cell development (GO:0014031)3.83305260
47protein targeting to membrane (GO:0006612)3.81367252
48lens fiber cell development (GO:0070307)3.80225970
49cilium movement (GO:0003341)3.70907147
50heart valve formation (GO:0003188)3.69469341
51Notch signaling involved in heart development (GO:0061314)3.69269322
52retinal ganglion cell axon guidance (GO:0031290)3.61804217
53lateral sprouting from an epithelium (GO:0060601)3.61043904
54axonemal dynein complex assembly (GO:0070286)3.60109263
55positive regulation of gastrulation (GO:2000543)3.58517171
56* midbrain development (GO:0030901)3.53202235
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52964675
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.52286677
59axon extension involved in axon guidance (GO:0048846)3.52286677
60positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.49454030
61endoderm formation (GO:0001706)3.46733274
62positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.44837568
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44773421
64vascular endothelial growth factor signaling pathway (GO:0038084)3.44712417
65pattern specification involved in kidney development (GO:0061004)3.41914385
66endocardial cushion morphogenesis (GO:0003203)3.41832431
67heart valve morphogenesis (GO:0003179)3.41435506
68negative regulation by host of viral transcription (GO:0043922)3.39052959
69positive regulation of respiratory burst (GO:0060267)3.38776164
70definitive hemopoiesis (GO:0060216)3.38437905
71sequestering of actin monomers (GO:0042989)3.36146861
72atrioventricular valve morphogenesis (GO:0003181)3.35637410
73establishment of planar polarity (GO:0001736)3.34573275
74establishment of tissue polarity (GO:0007164)3.34573275
75nuclear-transcribed mRNA catabolic process (GO:0000956)3.34189496
76behavioral response to nicotine (GO:0035095)3.33177944
77presynaptic membrane assembly (GO:0097105)3.32449752
78positive regulation by host of viral transcription (GO:0043923)3.31940851
79primitive streak formation (GO:0090009)3.31201871
80lymphangiogenesis (GO:0001946)3.30466945
81* neuron fate determination (GO:0048664)3.29481440
82sleep (GO:0030431)3.29467521
83presynaptic membrane organization (GO:0097090)3.25477567
84SMAD protein signal transduction (GO:0060395)3.23797870
85* stem cell development (GO:0048864)3.23372647
86heart trabecula morphogenesis (GO:0061384)3.18376608
87endothelial cell differentiation (GO:0045446)3.18258479
88dopaminergic neuron differentiation (GO:0071542)3.16024246
89mRNA catabolic process (GO:0006402)3.15900719
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.15204145
91cardiac right ventricle morphogenesis (GO:0003215)3.14940719
92regulation of somitogenesis (GO:0014807)3.14264167
93regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.11933644
94positive regulation of neuroblast proliferation (GO:0002052)3.11040482
95cilium or flagellum-dependent cell motility (GO:0001539)3.08369929
96cell surface receptor signaling pathway involved in heart development (GO:0061311)3.08323189
97negative regulation of axon extension (GO:0030517)3.08233564
98nonmotile primary cilium assembly (GO:0035058)3.06412894
99epithelial tube branching involved in lung morphogenesis (GO:0060441)3.06308913
100ventricular trabecula myocardium morphogenesis (GO:0003222)3.05227529
101centriole replication (GO:0007099)3.04753597
102epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.03639639
103limb bud formation (GO:0060174)3.01998196
104regulation of apoptotic process involved in morphogenesis (GO:1902337)3.01178380
105regulation of cell proliferation involved in kidney development (GO:1901722)3.00899238
106energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00690618
107ATP synthesis coupled proton transport (GO:0015986)3.00690618
108G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.00167078
109tonic smooth muscle contraction (GO:0014820)2.98835604
110negative regulation of catenin import into nucleus (GO:0035414)2.97737689
111regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.95202683
112mesenchyme morphogenesis (GO:0072132)2.94046467
113non-canonical Wnt signaling pathway (GO:0035567)2.93457881
114potassium ion export (GO:0071435)2.93349781
115sodium-independent organic anion transport (GO:0043252)2.93231581
116regulation of vasculogenesis (GO:2001212)2.93008075
117thalamus development (GO:0021794)2.91564809
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.87389141
119protein refolding (GO:0042026)2.85354193
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.85299260
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85228398
122negative regulation of astrocyte differentiation (GO:0048712)2.82680559
123patterning of blood vessels (GO:0001569)2.82433623
124positive regulation of odontogenesis (GO:0042482)2.82322047
125artery smooth muscle contraction (GO:0014824)2.82176508
126artery development (GO:0060840)2.82015977
127negative regulation of cell fate specification (GO:0009996)2.81914766
128negative regulation of Notch signaling pathway (GO:0045746)2.81370962
129hindbrain development (GO:0030902)2.79267747
130cardiac epithelial to mesenchymal transition (GO:0060317)2.79028686
131surfactant homeostasis (GO:0043129)2.78619895
132mitotic cell cycle arrest (GO:0071850)2.77564298
133substrate-independent telencephalic tangential migration (GO:0021826)2.76348828
134substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76348828
135germ cell migration (GO:0008354)2.74632033
136renal system development (GO:0072001)2.74120195
137establishment of nucleus localization (GO:0040023)2.74058494
138negative regulation of transcription by competitive promoter binding (GO:0010944)2.72823649
139auditory behavior (GO:0031223)2.72164664
140developmental induction (GO:0031128)2.70066286
141* cell-cell signaling involved in cell fate commitment (GO:0045168)2.70066286
142branching involved in salivary gland morphogenesis (GO:0060445)2.70040803
143RNA catabolic process (GO:0006401)2.69384340
144notochord development (GO:0030903)2.69034321
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.68854727
146cellular response to nitric oxide (GO:0071732)2.68824491
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67162605
148establishment of epithelial cell polarity (GO:0090162)2.67022785
149mesodermal cell differentiation (GO:0048333)2.66673801
150astrocyte differentiation (GO:0048708)2.66041563
151hemidesmosome assembly (GO:0031581)2.64244913
152* regulation of heart morphogenesis (GO:2000826)2.63557036
153positive regulation of interleukin-8 secretion (GO:2000484)2.62148919
154glomerulus development (GO:0032835)2.60460617
155endothelial cell morphogenesis (GO:0001886)2.57290674
156negative regulation of cell fate commitment (GO:0010454)2.55600435
157translation (GO:0006412)2.54623915
158negative regulation of myoblast differentiation (GO:0045662)2.54616313
159negative regulation of embryonic development (GO:0045992)2.54003292
160cell proliferation involved in kidney development (GO:0072111)2.53456527
161regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.52879569
162positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.51683402
163regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.51683402
164skeletal muscle cell differentiation (GO:0035914)2.50863874
165cell migration involved in sprouting angiogenesis (GO:0002042)2.49985502
166organ formation (GO:0048645)2.49844825
167face development (GO:0060324)2.48109387
168trabecula morphogenesis (GO:0061383)2.47490391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human7.79479649
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.22963434
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.43645960
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.15337013
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.15337013
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.15337013
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.08951572
8EZH2_22144423_ChIP-Seq_EOC_Human3.80179199
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.44684039
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96379870
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80356442
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.71890009
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.62839798
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32977290
15TP53_20018659_ChIP-ChIP_R1E_Mouse2.26804133
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24710314
17ZNF274_21170338_ChIP-Seq_K562_Hela2.24240941
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.23424891
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.22090816
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17043906
21RNF2_27304074_Chip-Seq_NSC_Mouse2.16385589
22GBX2_23144817_ChIP-Seq_PC3_Human2.14498816
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12350704
24FUS_26573619_Chip-Seq_HEK293_Human2.07684398
25CLOCK_20551151_ChIP-Seq_293T_Human2.06870007
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05545078
27* ESR2_21235772_ChIP-Seq_MCF-7_Human2.02244174
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01641309
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.99055265
30AR_21572438_ChIP-Seq_LNCaP_Human1.97222950
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92032685
32VDR_22108803_ChIP-Seq_LS180_Human1.88448762
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82859831
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.82797031
35* CDX2_20551321_ChIP-Seq_CACO-2_Human1.82637146
36EWS_26573619_Chip-Seq_HEK293_Human1.82212659
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.81970148
38* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78564739
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78299134
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73827205
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72812856
42P300_19829295_ChIP-Seq_ESCs_Human1.70522331
43* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70470404
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66184778
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65386861
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65045314
47* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61416308
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59772693
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59441560
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58885727
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56144890
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55879836
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54071080
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.52231713
55* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50571356
56SOX2_20726797_ChIP-Seq_SW620_Human1.50248511
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49826217
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49510556
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49413423
60* NOTCH1_21737748_ChIP-Seq_TLL_Human1.48384363
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47057183
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47040337
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46218322
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46139635
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44613165
66TAF15_26573619_Chip-Seq_HEK293_Human1.44169748
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.43344118
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41252465
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39822336
70* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39747748
71ZNF263_19887448_ChIP-Seq_K562_Human1.39687777
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39353530
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39353530
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.36164395
75* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36015284
76* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36015284
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35782729
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35782729
79* CJUN_26792858_Chip-Seq_BT549_Human1.35616507
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34003823
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32289333
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31501540
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31041994
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25187804
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25121007
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.24815546
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23425002
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23144013
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22178737
90* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22007138
91AR_25329375_ChIP-Seq_VCAP_Human1.21723654
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19806866
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19643037
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19446478
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17495573
96* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15842518
97* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15107236
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15080094
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13101911
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12829589
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12823746
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10842126
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10508586
104* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10388455
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.10041184
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.09536895
107RXR_22108803_ChIP-Seq_LS180_Human1.08895972
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08257169
109* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06260225
110* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05020480
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04659487
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.03850069
113* REST_21632747_ChIP-Seq_MESCs_Mouse1.02748483
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02303288
115* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02292389
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02207743
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02131118
118* GATA2_21666600_ChIP-Seq_HMVEC_Human1.01743138
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.01474054
120TP53_18474530_ChIP-ChIP_U2OS_Human1.01259553
121SOX2_16153702_ChIP-ChIP_HESCs_Human1.00276110
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.99755635
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99712342
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99342116
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98830140
126* GATA4_25053715_ChIP-Seq_YYC3_Human0.96991365
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96327046
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95277371
129* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94696005
130MYC_18940864_ChIP-ChIP_HL60_Human0.94299385
131SMAD4_21799915_ChIP-Seq_A2780_Human0.94003412
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93827695
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93786705
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93658261
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.93080980
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.92961262
137* AHR_22903824_ChIP-Seq_MCF-7_Human0.89940010
138* RUNX1_27514584_Chip-Seq_MCF-7_Human0.89136908
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.89042266
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88830034
141* ER_23166858_ChIP-Seq_MCF-7_Human0.88421630
142* SOX9_26525672_Chip-Seq_HEART_Mouse0.87826345
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87126769
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.86527000
145* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86195938
146BCAT_22108803_ChIP-Seq_LS180_Human0.85576770
147* ISL1_27105846_Chip-Seq_CPCs_Mouse0.85392242
148* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82921702
149* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81749359
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81198090
151* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81062513
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80041182
153* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79302246
154SCL_19346495_ChIP-Seq_HPC-7_Human0.78533115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.73554546
2MP0002653_abnormal_ependyma_morphology4.74650548
3MP0001879_abnormal_lymphatic_vessel3.83936550
4MP0002254_reproductive_system_inflammat3.43803519
5MP0003941_abnormal_skin_development3.31959361
6MP0010368_abnormal_lymphatic_system3.17488916
7MP0004272_abnormal_basement_membrane2.90247749
8MP0005623_abnormal_meninges_morphology2.85524981
9MP0003880_abnormal_central_pattern2.76369866
10MP0002009_preneoplasia2.72612102
11MP0010030_abnormal_orbit_morphology2.58938737
12MP0000762_abnormal_tongue_morphology2.53877946
13MP0002249_abnormal_larynx_morphology2.48318758
14MP0003283_abnormal_digestive_organ2.34848451
15MP0002796_impaired_skin_barrier2.27598526
16MP0005167_abnormal_blood-brain_barrier2.26301016
17MP0004381_abnormal_hair_follicle2.16422855
18MP0001485_abnormal_pinna_reflex2.15969155
19MP0009384_cardiac_valve_regurgitation2.14087671
20MP0000778_abnormal_nervous_system2.12638484
21MP0003828_pulmonary_edema2.10772413
22MP0005171_absent_coat_pigmentation2.03039997
23MP0005377_hearing/vestibular/ear_phenot1.98967392
24MP0003878_abnormal_ear_physiology1.98967392
25MP0002098_abnormal_vibrissa_morphology1.84116312
26MP0003724_increased_susceptibility_to1.77977764
27MP0000049_abnormal_middle_ear1.77887482
28MP0000566_synostosis1.76943422
29MP0004133_heterotaxia1.76634453
30* MP0000026_abnormal_inner_ear1.70385499
31MP0001293_anophthalmia1.68443846
32MP0006292_abnormal_olfactory_placode1.66585962
33MP0009278_abnormal_bone_marrow1.63232389
34MP0004142_abnormal_muscle_tone1.62815073
35MP0003011_delayed_dark_adaptation1.62654054
36MP0002060_abnormal_skin_morphology1.62036160
37MP0002638_abnormal_pupillary_reflex1.61830393
38MP0003279_aneurysm1.61746361
39MP0002277_abnormal_respiratory_mucosa1.61137572
40MP0005275_abnormal_skin_tensile1.59959331
41* MP0002928_abnormal_bile_duct1.59174676
42MP0002938_white_spotting1.58474320
43MP0000534_abnormal_ureter_morphology1.57291356
44MP0008004_abnormal_stomach_pH1.54758621
45MP0001346_abnormal_lacrimal_gland1.54531664
46MP0002234_abnormal_pharynx_morphology1.54397330
47MP0002282_abnormal_trachea_morphology1.52441641
48MP0002132_abnormal_respiratory_system1.50100519
49MP0009053_abnormal_anal_canal1.50060841
50MP0000613_abnormal_salivary_gland1.50042435
51MP0002127_abnormal_cardiovascular_syste1.40741484
52MP0000383_abnormal_hair_follicle1.35820822
53MP0005165_increased_susceptibility_to1.35372040
54MP0010234_abnormal_vibrissa_follicle1.34647688
55MP0004484_altered_response_of1.33266893
56* MP0000631_abnormal_neuroendocrine_gland1.31162156
57MP0005367_renal/urinary_system_phenotyp1.30152757
58MP0000516_abnormal_urinary_system1.30152757
59MP0004885_abnormal_endolymph1.29575446
60MP0006072_abnormal_retinal_apoptosis1.29234162
61MP0009250_abnormal_appendicular_skeleto1.29017928
62MP0006138_congestive_heart_failure1.27125151
63MP0003136_yellow_coat_color1.26794070
64MP0002751_abnormal_autonomic_nervous1.24116642
65MP0010678_abnormal_skin_adnexa1.22932934
66MP0002295_abnormal_pulmonary_circulatio1.22163982
67MP0005508_abnormal_skeleton_morphology1.21728472
68MP0003938_abnormal_ear_development1.20851352
69MP0000767_abnormal_smooth_muscle1.20096808
70MP0005174_abnormal_tail_pigmentation1.17666902
71MP0001958_emphysema1.17124444
72MP0000467_abnormal_esophagus_morphology1.15156445
73MP0005501_abnormal_skin_physiology1.15133773
74MP0000537_abnormal_urethra_morphology1.15002474
75MP0005187_abnormal_penis_morphology1.12991185
76MP0001216_abnormal_epidermal_layer1.12299866
77MP0000462_abnormal_digestive_system1.11692685
78MP0003453_abnormal_keratinocyte_physiol1.10170511
79MP0004742_abnormal_vestibular_system1.08467308
80MP0004883_abnormal_blood_vessel1.06395729
81MP0003122_maternal_imprinting1.05882950
82MP0002092_abnormal_eye_morphology1.04954510
83MP0001529_abnormal_vocalization1.04109686
84MP0002138_abnormal_hepatobiliary_system1.02874788
85MP0006054_spinal_hemorrhage1.02577947
86MP0002233_abnormal_nose_morphology1.02408989
87MP0000579_abnormal_nail_morphology0.99989276
88MP0003755_abnormal_palate_morphology0.99913397
89MP0003942_abnormal_urinary_system0.99564680
90MP0001486_abnormal_startle_reflex0.99487849
91MP0003638_abnormal_response/metabolism_0.98962472
92MP0005391_vision/eye_phenotype0.97759441
93MP0003935_abnormal_craniofacial_develop0.96993625
94MP0000569_abnormal_digit_pigmentation0.96977259
95* MP0005195_abnormal_posterior_eye0.94797915
96MP0010771_integument_phenotype0.94435094
97MP0005408_hypopigmentation0.93236445
98MP0009745_abnormal_behavioral_response0.93078162
99MP0005248_abnormal_Harderian_gland0.92628927
100MP0002697_abnormal_eye_size0.92328726
101MP0002111_abnormal_tail_morphology0.92215689
102MP0000163_abnormal_cartilage_morphology0.92098180
103MP0001324_abnormal_eye_pigmentation0.90701905
104MP0003890_abnormal_embryonic-extraembry0.90357691
105MP0001542_abnormal_bone_strength0.90029776
106MP0001963_abnormal_hearing_physiology0.89824448
107MP0005551_abnormal_eye_electrophysiolog0.88941236
108MP0000465_gastrointestinal_hemorrhage0.88269373
109MP0008789_abnormal_olfactory_epithelium0.87619976
110MP0003937_abnormal_limbs/digits/tail_de0.86804959
111* MP0000955_abnormal_spinal_cord0.82633553
112MP0003115_abnormal_respiratory_system0.82573634
113MP0001919_abnormal_reproductive_system0.82464184
114MP0002067_abnormal_sensory_capabilities0.82324837
115MP0005646_abnormal_pituitary_gland0.82164790
116MP0000372_irregular_coat_pigmentation0.82039843
117* MP0003861_abnormal_nervous_system0.81730359
118MP0002064_seizures0.81713054
119MP0005595_abnormal_vascular_smooth0.81476578
120MP0005503_abnormal_tendon_morphology0.81315313
121MP0002116_abnormal_craniofacial_bone0.80840592
122MP0002102_abnormal_ear_morphology0.79654358
123MP0002932_abnormal_joint_morphology0.79149006
124MP0002095_abnormal_skin_pigmentation0.79012635
125* MP0000432_abnormal_head_morphology0.78125591
126MP0005423_abnormal_somatic_nervous0.77307522
127MP0002572_abnormal_emotion/affect_behav0.76403127
128* MP0002752_abnormal_somatic_nervous0.76220217
129MP0003385_abnormal_body_wall0.75634159
130MP0002177_abnormal_outer_ear0.75323614
131MP0005023_abnormal_wound_healing0.75202690
132MP0003119_abnormal_digestive_system0.74792447
133MP0008961_abnormal_basal_metabolism0.74694583
134MP0002108_abnormal_muscle_morphology0.73534167
135MP0000647_abnormal_sebaceous_gland0.73415654
136MP0002128_abnormal_blood_circulation0.72081830
137MP0003566_abnormal_cell_adhesion0.71960107
138MP0005164_abnormal_response_to0.71660725
139MP0002166_altered_tumor_susceptibility0.71596050
140MP0001340_abnormal_eyelid_morphology0.71028688
141MP0002972_abnormal_cardiac_muscle0.70821684
142MP0005381_digestive/alimentary_phenotyp0.70697975
143MP0004019_abnormal_vitamin_homeostasis0.70246759
144MP0001270_distended_abdomen0.70206707
145MP0003943_abnormal_hepatobiliary_system0.69880817
146MP0001299_abnormal_eye_distance/0.69517548
147MP0002272_abnormal_nervous_system0.69013110
148* MP0001286_abnormal_eye_development0.68960104
149MP0008995_early_reproductive_senescence0.68769966
150MP0005253_abnormal_eye_physiology0.68683059
151MP0001784_abnormal_fluid_regulation0.68203855
152* MP0002152_abnormal_brain_morphology0.67241902
153MP0002109_abnormal_limb_morphology0.66890788
154MP0001663_abnormal_digestive_system0.66822372
155MP0002822_catalepsy0.66532107
156MP0002557_abnormal_social/conspecific_i0.66488736
157MP0000249_abnormal_blood_vessel0.65351526
158MP0002925_abnormal_cardiovascular_devel0.65046360
159MP0001984_abnormal_olfaction0.64630796
160MP0003936_abnormal_reproductive_system0.62121475
161MP0003315_abnormal_perineum_morphology0.61421874

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.65525323
2Abnormality of cells of the erythroid lineage (HP:0012130)4.76665330
3Abnormal hemoglobin (HP:0011902)4.64702222
4Stenosis of the external auditory canal (HP:0000402)4.38982125
5Septo-optic dysplasia (HP:0100842)4.38035031
6Macrocytic anemia (HP:0001972)4.33092540
7True hermaphroditism (HP:0010459)4.00399743
8Partial duplication of thumb phalanx (HP:0009944)3.87848613
9Abnormal number of erythroid precursors (HP:0012131)3.86543798
10Congenital, generalized hypertrichosis (HP:0004540)3.85397496
11Onycholysis (HP:0001806)3.76191215
12Partial duplication of the phalanx of hand (HP:0009999)3.71994548
13Split foot (HP:0001839)3.57067148
14Abnormal ciliary motility (HP:0012262)3.55029625
15Abnormality of the axillary hair (HP:0100134)3.53810460
16Abnormality of secondary sexual hair (HP:0009888)3.53810460
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.49567972
18Absent/shortened dynein arms (HP:0200106)3.49567972
19Type II lissencephaly (HP:0007260)3.36396977
20Pallor (HP:0000980)3.32264280
21Maternal diabetes (HP:0009800)3.27611271
22Pancreatic fibrosis (HP:0100732)3.25919498
23Pancreatic cysts (HP:0001737)3.15775796
24Rib fusion (HP:0000902)3.12676709
25Abnormal respiratory motile cilium morphology (HP:0005938)3.10702556
26Abnormal respiratory epithelium morphology (HP:0012253)3.10702556
27Abnormal respiratory motile cilium physiology (HP:0012261)3.10499834
28Bilateral microphthalmos (HP:0007633)3.02527354
29Ridged nail (HP:0001807)2.94336220
30Abnormality of the diencephalon (HP:0010662)2.94173929
31Aplasia cutis congenita (HP:0001057)2.93108406
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92553939
33Cerebellar dysplasia (HP:0007033)2.86621314
34Absent septum pellucidum (HP:0001331)2.72758028
35Esophageal atresia (HP:0002032)2.72304332
36Hemivertebrae (HP:0002937)2.70953238
37Synostosis involving the elbow (HP:0003938)2.69623043
38Humeroradial synostosis (HP:0003041)2.69623043
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69522929
40Sclerocornea (HP:0000647)2.68905347
41Abnormality of midbrain morphology (HP:0002418)2.67814332
42Molar tooth sign on MRI (HP:0002419)2.67814332
43Natal tooth (HP:0000695)2.65188262
4411 pairs of ribs (HP:0000878)2.59147740
45Supernumerary ribs (HP:0005815)2.58528559
46Woolly hair (HP:0002224)2.55148918
47Bone cyst (HP:0012062)2.55121610
48Supernumerary bones of the axial skeleton (HP:0009144)2.54515204
49Abnormality of the parietal bone (HP:0002696)2.54433908
50Xerostomia (HP:0000217)2.52575123
51Plantar hyperkeratosis (HP:0007556)2.52117661
52Hypotrichosis (HP:0001006)2.52031684
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51540825
54Short hallux (HP:0010109)2.48885007
55Tubular atrophy (HP:0000092)2.48441783
56Nephronophthisis (HP:0000090)2.47851371
57Colon cancer (HP:0003003)2.47167820
58Synostosis involving bones of the feet (HP:0009140)2.44145807
59Synostosis involving bones of the lower limbs (HP:0009138)2.44145807
60Aplasia involving bones of the upper limbs (HP:0009823)2.43232978
61Aplasia of the phalanges of the hand (HP:0009802)2.43232978
62Aplasia involving bones of the extremities (HP:0009825)2.43232978
63Abnormal number of incisors (HP:0011064)2.41739104
64Abnormality of placental membranes (HP:0011409)2.41678376
65Amniotic constriction ring (HP:0009775)2.41678376
66Parakeratosis (HP:0001036)2.38055823
67Neonatal short-limb short stature (HP:0008921)2.37732567
68Abnormality of the pons (HP:0007361)2.37404596
69Absent hand (HP:0004050)2.36946273
70Cystic liver disease (HP:0006706)2.35616981
71Acanthosis nigricans (HP:0000956)2.34909280
72Medial flaring of the eyebrow (HP:0010747)2.34679752
73Aplasia/Hypoplasia of the fibula (HP:0006492)2.34246593
74Ventricular fibrillation (HP:0001663)2.33232432
75Down-sloping shoulders (HP:0200021)2.32207820
76Fragile skin (HP:0001030)2.32020456
77Large for gestational age (HP:0001520)2.31797605
78Hypoplastic pelvis (HP:0008839)2.30695534
79Milia (HP:0001056)2.30522524
80Tarsal synostosis (HP:0008368)2.29604036
81Right ventricular cardiomyopathy (HP:0011663)2.29581495
82Hydroureter (HP:0000072)2.29242152
83Hypoplasia of the pons (HP:0012110)2.26305782
84Hemiparesis (HP:0001269)2.24074670
85Rhinitis (HP:0012384)2.22912926
86Palmoplantar hyperkeratosis (HP:0000972)2.22176996
87Nasolacrimal duct obstruction (HP:0000579)2.21863809
88Palmar hyperkeratosis (HP:0010765)2.20936742
89Conical tooth (HP:0000698)2.20874762
90Oligodactyly (HP:0012165)2.20176939
91Fibular aplasia (HP:0002990)2.20123774
92Abnormality of the renal medulla (HP:0100957)2.19980876
93Short 4th metacarpal (HP:0010044)2.19786355
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19786355
95Growth hormone excess (HP:0000845)2.19644451
96Optic nerve hypoplasia (HP:0000609)2.19073599
97Abnormality of the 4th metacarpal (HP:0010012)2.16278367
98Gastrointestinal atresia (HP:0002589)2.13735867
99Concave nail (HP:0001598)2.11940271
100Aplasia/Hypoplasia of the hallux (HP:0008362)2.11785692
101Atrophic scars (HP:0001075)2.09999659
102Bronchomalacia (HP:0002780)2.09828179
103Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09788647
104Asplenia (HP:0001746)2.09670515
105Prominent supraorbital ridges (HP:0000336)2.09588045
106Fragile nails (HP:0001808)2.09357629
107Congenital stationary night blindness (HP:0007642)2.09142667
108Fibular hypoplasia (HP:0003038)2.08585034
109Preaxial foot polydactyly (HP:0001841)2.08563609
110Metaphyseal dysplasia (HP:0100255)2.07776389
111Abnormal sex determination (HP:0012244)2.07760438
112Sex reversal (HP:0012245)2.07760438
113Hypoplasia of the uterus (HP:0000013)2.06841714
114Abnormality of the septum pellucidum (HP:0007375)2.06579129
115Synostosis of carpal bones (HP:0005048)2.05437054
116Increased hepatocellular lipid droplets (HP:0006565)2.05404263
117Male pseudohermaphroditism (HP:0000037)2.04481296
118Hypoplasia of the ulna (HP:0003022)2.04276072
119Hypoplastic labia majora (HP:0000059)2.03723600
120Triphalangeal thumb (HP:0001199)2.03408356
121Vertebral fusion (HP:0002948)2.03349336
122Aplasia/Hypoplasia of the uvula (HP:0010293)2.02955288
123Gait imbalance (HP:0002141)2.00231000
124Aplasia/hypoplasia of the uterus (HP:0008684)1.99820011
125Adactyly (HP:0009776)1.99284190
126Pulmonary artery stenosis (HP:0004415)1.98996397
127Congenital primary aphakia (HP:0007707)1.98039564
128Absent toe (HP:0010760)1.97834277
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95317613
130Abnormality of the incisor (HP:0000676)1.95127301
131Genital tract atresia (HP:0001827)1.94826167
132Congenital sensorineural hearing impairment (HP:0008527)1.93828703
133Abnormality of the pubic bones (HP:0003172)1.93556505
134Anencephaly (HP:0002323)1.93424129
135Hypoplasia of the radius (HP:0002984)1.91537447
136Hypoplasia of the iris (HP:0007676)1.91415780
137Renal Fanconi syndrome (HP:0001994)1.91263162
138Hypoplastic left heart (HP:0004383)1.90959823
139Vaginal atresia (HP:0000148)1.90466108
140Patellar aplasia (HP:0006443)1.89485125
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.89298280
142Polydipsia (HP:0001959)1.88111477
143Abnormal drinking behavior (HP:0030082)1.88111477
144Duplication of thumb phalanx (HP:0009942)1.87372156
145Esophageal varix (HP:0002040)1.87145385
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86487913
147Abnormality of the lacrimal duct (HP:0011481)1.86362096
148Specific learning disability (HP:0001328)1.86191648
149Renal dysplasia (HP:0000110)1.86082139
150Aplasia/Hypoplasia of the ulna (HP:0006495)1.85143427
151Abnormality of the labia majora (HP:0012881)1.84830824
152Premature rupture of membranes (HP:0001788)1.84418263
153Anophthalmia (HP:0000528)1.84108824
154Pterygium (HP:0001059)1.83861043
155Advanced eruption of teeth (HP:0006288)1.83526054
156Holoprosencephaly (HP:0001360)1.82498491
157Abnormality of the middle phalanges of the toes (HP:0010183)1.82391687
158Migraine (HP:0002076)1.82111044
159Abnormality of the right ventricle (HP:0001707)1.81812384
160Aplasia of the musculature (HP:0100854)1.81376317
161Ventricular tachycardia (HP:0004756)1.81306417
162Aplasia/Hypoplasia of the patella (HP:0006498)1.80142174
163Aortic aneurysm (HP:0004942)1.77597525
164Absent radius (HP:0003974)1.77293112
165Mesangial abnormality (HP:0001966)1.76437019
166Absent hair (HP:0002298)1.75545511
167Absent forearm bone (HP:0003953)1.74681027
168Aplasia involving forearm bones (HP:0009822)1.74681027
169Abnormality of the nasolacrimal system (HP:0000614)1.74601732
170Lipid accumulation in hepatocytes (HP:0006561)1.73681314
171Sparse scalp hair (HP:0002209)1.73327222
172Intestinal atresia (HP:0011100)1.72817219
173Missing ribs (HP:0000921)1.72149879
174Overfolded helix (HP:0000396)1.70427446
175Exertional dyspnea (HP:0002875)1.68553123
176Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.67561422
177Vertebral hypoplasia (HP:0008417)1.67561422
178Oligodactyly (hands) (HP:0001180)1.66945479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.53039668
2MAP2K25.85694529
3TSSK65.12960353
4WEE14.00971965
5TIE13.53082460
6MAPK153.29227645
7EPHB23.27253155
8MYLK3.12050316
9TGFBR22.90603701
10MST42.76212022
11KDR2.55900829
12TNIK2.49924479
13NUAK12.47362014
14GRK12.25699064
15MAPK72.25687794
16MAP3K21.96346426
17LMTK21.85792108
18NME21.76082205
19RPS6KB21.74574811
20INSRR1.61977891
21MKNK21.58554954
22EPHA21.58000454
23MAP3K121.56133712
24PBK1.53743449
25FGFR21.49021260
26PRKG21.46095080
27MKNK11.44502502
28AKT31.42216111
29TLK11.40195917
30MAPK41.35774733
31NTRK21.33721052
32LRRK21.32733813
33PIM21.27902367
34GRK71.26989224
35BMPR1B1.25148708
36TGFBR11.23886624
37RIPK11.23386668
38FER1.20973120
39MAP3K31.15325258
40IKBKB1.14724776
41MOS1.13305192
42PAK21.12282132
43WNK31.10760061
44IRAK11.10683009
45PIK3CG1.09377372
46EIF2AK21.08289026
47PLK31.07891257
48TYRO31.07610682
49MST1R1.06414936
50MAP2K11.02984960
51BUB11.01073632
52MAPKAPK50.99823072
53CDK60.97340759
54FRK0.97074324
55PAK40.96338253
56NLK0.93587711
57RPS6KL10.93572412
58RPS6KC10.93572412
59CDK30.93569982
60STK390.92435478
61CASK0.92249127
62BCR0.91517545
63RPS6KA20.89574123
64ZAK0.87050562
65MUSK0.84369943
66BRSK20.81965514
67STK100.81814089
68ADRBK10.81645803
69AURKB0.81539084
70VRK10.78163520
71RPS6KA60.77999460
72ERBB20.77483679
73EPHA40.75538116
74DAPK30.73838967
75HIPK20.71241132
76VRK20.70315755
77PINK10.70102695
78BRD40.69659868
79STK160.68143383
80GSK3A0.67827233
81PRKCG0.67202168
82ADRBK20.65908039
83PRKD20.64339470
84IRAK30.64159894
85CDK80.62863357
86PKN10.62591485
87GRK50.62467561
88CDK70.61465204
89PTK2B0.61002282
90ILK0.59781083
91RPS6KA10.59729388
92DYRK30.58924882
93DYRK20.58288326
94SIK10.58143186
95STK38L0.57050030
96AURKA0.56814989
97PAK30.56154975
98CAMK1G0.55289356
99PRKCE0.55003996
100MELK0.53110647
101EPHA30.51981232
102PTK60.51952930
103ROCK10.50775892
104MAP3K100.50212459
105NTRK30.48878548
106IRAK20.48736883
107PDK20.48451622
108CDK190.46695288
109IRAK40.46683546
110BLK0.45842272
111FGR0.45206653
112PDGFRA0.45102751
113PIK3CA0.44580676
114NME10.44384599
115CAMK1D0.43949835
116PTK20.43698244
117CHUK0.43466289
118MAPK30.43078709
119MAPK130.42533495
120PRKD10.41987766
121MAP3K110.41526114
122AKT20.41324396
123MAPKAPK30.41321792
124RPS6KA50.40900218
125PASK0.39281019
126MAPKAPK20.38645434
127IGF1R0.36183656
128NEK20.35961011
129STK240.35216986
130FGFR10.35041836
131ABL20.34987139
132MAP3K40.34841741
133IKBKE0.34643441
134CAMK10.33974007
135MAPK90.33615791
136OXSR10.31047811
137WNK40.30988589
138SGK20.29904099
139DDR20.29245028
140DYRK1A0.27610906
141MAP2K40.25712639
142MARK10.24545255
143PRKACA0.23825797
144TAOK30.22731338
145SGK4940.21774456
146SGK2230.21774456
147PRKG10.21603409
148OBSCN0.21439193
149TAF10.20600032
150BCKDK0.18751165
151MAP3K70.18453325
152CHEK20.16750530
153BRSK10.16133079
154DMPK0.15704599
155CSNK2A20.13845534
156CSNK2A10.13757786
157STK40.12926666

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.61941980
2Basal cell carcinoma_Homo sapiens_hsa052172.88946938
3ECM-receptor interaction_Homo sapiens_hsa045122.57922231
4* Maturity onset diabetes of the young_Homo sapiens_hsa049502.22962594
5Nitrogen metabolism_Homo sapiens_hsa009102.17691235
6Oxidative phosphorylation_Homo sapiens_hsa001902.02687532
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02656141
8Hedgehog signaling pathway_Homo sapiens_hsa043401.97429559
9Cocaine addiction_Homo sapiens_hsa050301.85364215
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.78387010
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75876845
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74845062
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67402126
14Chemical carcinogenesis_Homo sapiens_hsa052041.64887830
15Parkinsons disease_Homo sapiens_hsa050121.62377743
16Arachidonic acid metabolism_Homo sapiens_hsa005901.60544979
17Retinol metabolism_Homo sapiens_hsa008301.57605546
18TGF-beta signaling pathway_Homo sapiens_hsa043501.56264909
19Hippo signaling pathway_Homo sapiens_hsa043901.52480374
20Nicotine addiction_Homo sapiens_hsa050331.48746837
21Alzheimers disease_Homo sapiens_hsa050101.48298856
22Adherens junction_Homo sapiens_hsa045201.45567944
23Melanogenesis_Homo sapiens_hsa049161.45405622
24Butanoate metabolism_Homo sapiens_hsa006501.43765014
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42556369
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41904817
27Wnt signaling pathway_Homo sapiens_hsa043101.36834306
28Linoleic acid metabolism_Homo sapiens_hsa005911.36585987
29Tight junction_Homo sapiens_hsa045301.36497240
30Bladder cancer_Homo sapiens_hsa052191.32859307
31Phototransduction_Homo sapiens_hsa047441.32788181
32Focal adhesion_Homo sapiens_hsa045101.32729819
33Huntingtons disease_Homo sapiens_hsa050161.29034704
34Glutathione metabolism_Homo sapiens_hsa004801.22556440
35Protein digestion and absorption_Homo sapiens_hsa049741.22517991
36Pathways in cancer_Homo sapiens_hsa052001.21098555
37Prion diseases_Homo sapiens_hsa050201.20351787
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.17978986
39Taste transduction_Homo sapiens_hsa047421.17884034
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15517983
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15177044
42Proteoglycans in cancer_Homo sapiens_hsa052051.14137951
43Cardiac muscle contraction_Homo sapiens_hsa042601.11557617
44* Notch signaling pathway_Homo sapiens_hsa043301.11368499
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.10038519
46Amphetamine addiction_Homo sapiens_hsa050311.07102999
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06507571
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05862380
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04746696
50Rap1 signaling pathway_Homo sapiens_hsa040151.03159724
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03092104
52Homologous recombination_Homo sapiens_hsa034400.99519860
53Axon guidance_Homo sapiens_hsa043600.97643432
54Small cell lung cancer_Homo sapiens_hsa052220.96086277
55Histidine metabolism_Homo sapiens_hsa003400.95982837
56Propanoate metabolism_Homo sapiens_hsa006400.95342629
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94494827
58HTLV-I infection_Homo sapiens_hsa051660.93416355
59RNA polymerase_Homo sapiens_hsa030200.92178420
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91879307
61Mineral absorption_Homo sapiens_hsa049780.91151431
62Sulfur relay system_Homo sapiens_hsa041220.89522897
63Caffeine metabolism_Homo sapiens_hsa002320.89191374
64Dilated cardiomyopathy_Homo sapiens_hsa054140.85689063
65Insulin secretion_Homo sapiens_hsa049110.82224312
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81954040
67Tryptophan metabolism_Homo sapiens_hsa003800.81928598
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81468680
69Estrogen signaling pathway_Homo sapiens_hsa049150.80656009
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.80295317
71Selenocompound metabolism_Homo sapiens_hsa004500.79379699
72MicroRNAs in cancer_Homo sapiens_hsa052060.78089786
73Spliceosome_Homo sapiens_hsa030400.77945472
74Melanoma_Homo sapiens_hsa052180.77564433
75Complement and coagulation cascades_Homo sapiens_hsa046100.76720840
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.76521263
77Phenylalanine metabolism_Homo sapiens_hsa003600.73588935
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71682524
79Basal transcription factors_Homo sapiens_hsa030220.71009216
80TNF signaling pathway_Homo sapiens_hsa046680.70627254
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70137530
82Platelet activation_Homo sapiens_hsa046110.70038692
83African trypanosomiasis_Homo sapiens_hsa051430.69296155
84Glutamatergic synapse_Homo sapiens_hsa047240.67626101
85Ras signaling pathway_Homo sapiens_hsa040140.67594897
86Dorso-ventral axis formation_Homo sapiens_hsa043200.64144535
87GABAergic synapse_Homo sapiens_hsa047270.63402391
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62555204
89* Fanconi anemia pathway_Homo sapiens_hsa034600.61810582
90p53 signaling pathway_Homo sapiens_hsa041150.61609444
91Nucleotide excision repair_Homo sapiens_hsa034200.61412599
92Amoebiasis_Homo sapiens_hsa051460.60581702
93Rheumatoid arthritis_Homo sapiens_hsa053230.59818542
94Morphine addiction_Homo sapiens_hsa050320.59079937
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58876183
96Pancreatic secretion_Homo sapiens_hsa049720.57538215
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56316622
98Prostate cancer_Homo sapiens_hsa052150.56055308
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55710212
100Pertussis_Homo sapiens_hsa051330.55081751
101Bile secretion_Homo sapiens_hsa049760.55020542
102MAPK signaling pathway_Homo sapiens_hsa040100.54677254
103HIF-1 signaling pathway_Homo sapiens_hsa040660.54628856
104Systemic lupus erythematosus_Homo sapiens_hsa053220.54536862
105Vitamin digestion and absorption_Homo sapiens_hsa049770.53630538
106Fat digestion and absorption_Homo sapiens_hsa049750.52383052
107Olfactory transduction_Homo sapiens_hsa047400.52301482
108Circadian entrainment_Homo sapiens_hsa047130.51812247
109Salivary secretion_Homo sapiens_hsa049700.50829549
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.50268110
111Protein export_Homo sapiens_hsa030600.48027281
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47489080
113RNA degradation_Homo sapiens_hsa030180.46567293
114Ovarian steroidogenesis_Homo sapiens_hsa049130.46355363
115Folate biosynthesis_Homo sapiens_hsa007900.45241297
116Choline metabolism in cancer_Homo sapiens_hsa052310.45210095
117Gap junction_Homo sapiens_hsa045400.45184599
118Tyrosine metabolism_Homo sapiens_hsa003500.45009898
119Calcium signaling pathway_Homo sapiens_hsa040200.43837348
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43710224
121Steroid biosynthesis_Homo sapiens_hsa001000.42555007
122Ether lipid metabolism_Homo sapiens_hsa005650.41584301
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40754400
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.40668492
125Sphingolipid metabolism_Homo sapiens_hsa006000.40656269
126Serotonergic synapse_Homo sapiens_hsa047260.40325439
127PPAR signaling pathway_Homo sapiens_hsa033200.39748459
128ABC transporters_Homo sapiens_hsa020100.38428766
129Alcoholism_Homo sapiens_hsa050340.38215899
130Colorectal cancer_Homo sapiens_hsa052100.38192154
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37983803
132Fatty acid elongation_Homo sapiens_hsa000620.37857335
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37251282
134Arginine and proline metabolism_Homo sapiens_hsa003300.37233403
135Renin secretion_Homo sapiens_hsa049240.36837152
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35797719
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35789966
138Starch and sucrose metabolism_Homo sapiens_hsa005000.34639720
139Gastric acid secretion_Homo sapiens_hsa049710.34334369
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34237065
141cAMP signaling pathway_Homo sapiens_hsa040240.33899411
142beta-Alanine metabolism_Homo sapiens_hsa004100.30421999
143Metabolic pathways_Homo sapiens_hsa011000.29349883
144Dopaminergic synapse_Homo sapiens_hsa047280.28801187
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26651947
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25634781

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