HES2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.46285105
2desmosome organization (GO:0002934)6.39375033
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.20551263
4virion attachment to host cell (GO:0019062)5.77090554
5adhesion of symbiont to host cell (GO:0044650)5.77090554
6positive regulation of cellular amide metabolic process (GO:0034250)5.28997810
7intestinal cholesterol absorption (GO:0030299)5.14739893
8keratinocyte development (GO:0003334)5.12345026
9behavioral response to nicotine (GO:0035095)5.00242941
10keratinocyte proliferation (GO:0043616)4.93445152
11adhesion of symbiont to host (GO:0044406)4.85284653
12angiotensin maturation (GO:0002003)4.82447682
13fucose catabolic process (GO:0019317)4.33995553
14L-fucose metabolic process (GO:0042354)4.33995553
15L-fucose catabolic process (GO:0042355)4.33995553
16superoxide anion generation (GO:0042554)4.26829385
17intestinal absorption (GO:0050892)4.25183246
18nucleotide transmembrane transport (GO:1901679)4.15332966
19platelet dense granule organization (GO:0060155)4.13395312
20molting cycle (GO:0042303)4.09710165
21hair cycle (GO:0042633)4.09710165
22response to pheromone (GO:0019236)4.06701036
23neutrophil activation involved in immune response (GO:0002283)4.04809553
24dendritic cell chemotaxis (GO:0002407)4.01272037
25establishment of skin barrier (GO:0061436)3.99815116
26intermediate filament organization (GO:0045109)3.98161780
27oligosaccharide catabolic process (GO:0009313)3.98085744
28negative regulation of keratinocyte proliferation (GO:0010839)3.94991522
29dendritic cell migration (GO:0036336)3.92847794
30water-soluble vitamin biosynthetic process (GO:0042364)3.92819884
31transcytosis (GO:0045056)3.91408162
32neutrophil activation (GO:0042119)3.88099431
33positive regulation of monocyte chemotaxis (GO:0090026)3.86805387
34regulation of interleukin-8 secretion (GO:2000482)3.83984351
35regulation of keratinocyte proliferation (GO:0010837)3.80617163
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.71877322
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70900539
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70900539
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.70900539
40modulation by symbiont of host immune response (GO:0052553)3.70900539
41positive regulation by symbiont of host defense response (GO:0052509)3.70900539
42modulation by symbiont of host defense response (GO:0052031)3.70900539
43detection of molecule of bacterial origin (GO:0032490)3.69742790
44detection of other organism (GO:0098543)3.66493304
45keratinization (GO:0031424)3.65575984
46cornea development in camera-type eye (GO:0061303)3.56289090
47response to peptidoglycan (GO:0032494)3.55582988
48detection of bacterium (GO:0016045)3.54906878
49granulocyte activation (GO:0036230)3.54089901
50respiratory burst (GO:0045730)3.49694732
51epithelial cilium movement (GO:0003351)3.41491724
52positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.37736432
53histamine secretion (GO:0001821)3.36657537
54production of molecular mediator involved in inflammatory response (GO:0002532)3.31719207
55detection of external biotic stimulus (GO:0098581)3.30959049
56regulation of water loss via skin (GO:0033561)3.28280999
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.26436995
58positive regulation of mast cell degranulation (GO:0043306)3.26436995
59establishment of tissue polarity (GO:0007164)3.26083498
60establishment of planar polarity (GO:0001736)3.26083498
61regulation of activation of Janus kinase activity (GO:0010533)3.22902629
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22100990
63meiotic chromosome segregation (GO:0045132)3.16912810
64hydrogen peroxide biosynthetic process (GO:0050665)3.16674097
65kynurenine metabolic process (GO:0070189)3.12313925
66nucleotide transport (GO:0006862)3.10810283
67regulation of cellular extravasation (GO:0002691)3.07730053
68positive regulation of T cell chemotaxis (GO:0010820)3.07672629
69regulation of T cell chemotaxis (GO:0010819)3.07672629
70tryptophan catabolic process (GO:0006569)3.05467712
71indole-containing compound catabolic process (GO:0042436)3.05467712
72indolalkylamine catabolic process (GO:0046218)3.05467712
73negative regulation of telomere maintenance (GO:0032205)3.03581946
74phosphatidylinositol acyl-chain remodeling (GO:0036149)3.03287824
75respiratory chain complex IV assembly (GO:0008535)3.02630303
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02215641
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01788010
78macrophage activation involved in immune response (GO:0002281)3.01362700
79magnesium ion transport (GO:0015693)2.97212365
80regulation of hippo signaling (GO:0035330)2.95513499
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95458449
82epidermis development (GO:0008544)2.95353275
83polyol transport (GO:0015791)2.95159386
84energy homeostasis (GO:0097009)2.94034984
85cilium movement (GO:0003341)2.93323983
86positive regulation of interleukin-1 beta secretion (GO:0050718)2.92794624
87regulation of interleukin-1 beta secretion (GO:0050706)2.91952949
88reactive oxygen species biosynthetic process (GO:1903409)2.91123388
89axoneme assembly (GO:0035082)2.91118305
90positive regulation of interleukin-8 secretion (GO:2000484)2.88311768
91regulation of cilium movement (GO:0003352)2.87541393
92protein complex biogenesis (GO:0070271)2.86771880
93cardiac right ventricle morphogenesis (GO:0003215)2.86571805
94preassembly of GPI anchor in ER membrane (GO:0016254)2.86338313
95regulation of monocyte chemotaxis (GO:0090025)2.85524850
96positive regulation of leukocyte degranulation (GO:0043302)2.85131921
97positive regulation of interleukin-6 production (GO:0032755)2.84880318
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.84208016
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84114932
100ectoderm development (GO:0007398)2.83135425
101indolalkylamine metabolic process (GO:0006586)2.82729109
102piRNA metabolic process (GO:0034587)2.80895019
103polarized epithelial cell differentiation (GO:0030859)2.80731640
104positive regulation of mast cell activation (GO:0033005)2.80477495
105estrogen biosynthetic process (GO:0006703)2.80311992
106thrombin receptor signaling pathway (GO:0070493)2.79751338
107immunoglobulin mediated immune response (GO:0016064)2.79177473
108adenine nucleotide transport (GO:0051503)2.78203110
109superoxide metabolic process (GO:0006801)2.77905697
110muscle atrophy (GO:0014889)2.76722507
111negative regulation of epidermis development (GO:0045683)2.76618671
112intermediate filament-based process (GO:0045103)2.76181678
113surfactant homeostasis (GO:0043129)2.75939460
114intermediate filament cytoskeleton organization (GO:0045104)2.75890838
115protein-cofactor linkage (GO:0018065)2.75866566
116intestinal epithelial cell development (GO:0060576)2.75332780
117lateral sprouting from an epithelium (GO:0060601)2.74664516
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74039176
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73488618
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.73488618
121NADH dehydrogenase complex assembly (GO:0010257)2.73488618
122peptide catabolic process (GO:0043171)2.73204750
123DNA deamination (GO:0045006)2.72884722
124regulation of chemokine secretion (GO:0090196)2.72841899
125cellular ketone body metabolic process (GO:0046950)2.72771596
126fucosylation (GO:0036065)2.72560766
127interferon-gamma-mediated signaling pathway (GO:0060333)2.71189971
128regulation of glucokinase activity (GO:0033131)2.70036579
129regulation of hexokinase activity (GO:1903299)2.70036579
130wound healing, spreading of epidermal cells (GO:0035313)2.69020445
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69012175
132detection of biotic stimulus (GO:0009595)2.68889165
133mitochondrial respiratory chain complex assembly (GO:0033108)2.67589735
134positive regulation of interleukin-1 secretion (GO:0050716)2.67437469
135cytokine secretion (GO:0050663)2.66542578
136mannosylation (GO:0097502)2.66222377
137notochord development (GO:0030903)2.66097936
138detection of light stimulus involved in sensory perception (GO:0050962)2.65977418
139detection of light stimulus involved in visual perception (GO:0050908)2.65977418
140phosphatidylserine acyl-chain remodeling (GO:0036150)2.65038882
141cytochrome complex assembly (GO:0017004)2.64990942
142sphingoid metabolic process (GO:0046519)2.64930450
143regulation of mesoderm development (GO:2000380)2.64252117
144regulation of action potential (GO:0098900)2.63799078
145cellular response to ATP (GO:0071318)2.62142554
146very-low-density lipoprotein particle assembly (GO:0034379)2.61114831
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61103272
148regulation of mast cell degranulation (GO:0043304)2.60249746
149response to hydroperoxide (GO:0033194)2.60234315
150multicellular organism reproduction (GO:0032504)2.60004496
151negative regulation of protein autophosphorylation (GO:0031953)2.59328890
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58510100
153leukocyte aggregation (GO:0070486)2.58175645
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57985933
155kinetochore assembly (GO:0051382)2.57587680
156neural tube formation (GO:0001841)2.56725045
157drinking behavior (GO:0042756)2.56682589
158positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.55747274
159monocyte chemotaxis (GO:0002548)2.54948309
160negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54320811
161positive regulation of antigen processing and presentation (GO:0002579)2.54200487
162pseudouridine synthesis (GO:0001522)2.51570509
163axonemal dynein complex assembly (GO:0070286)2.51552870
164reflex (GO:0060004)2.50761226
165cilium morphogenesis (GO:0060271)2.50127953
166limb bud formation (GO:0060174)2.50040917
167energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50031985
168ATP synthesis coupled proton transport (GO:0015986)2.50031985
169protein polyglutamylation (GO:0018095)2.49680233
170leukocyte cell-cell adhesion (GO:0007159)2.49241160
171lipoxygenase pathway (GO:0019372)2.49000853
172phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.47800803
173tryptophan metabolic process (GO:0006568)2.47747778
174NAD biosynthetic process (GO:0009435)2.47054175
175nonmotile primary cilium assembly (GO:0035058)2.46845193
176regulation of leukocyte degranulation (GO:0043300)2.46510980
177microglial cell activation (GO:0001774)2.46225058
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46110892
179response to host immune response (GO:0052572)2.46110892
180GPI anchor metabolic process (GO:0006505)2.45940189
181negative regulation of epidermal cell differentiation (GO:0045605)2.44768542
182positive regulation of type 2 immune response (GO:0002830)2.44682426
183regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.44407254
184cilium organization (GO:0044782)2.44277549
185leukotriene metabolic process (GO:0006691)2.44255337
186negative regulation of acute inflammatory response (GO:0002674)2.44015161
187cilium or flagellum-dependent cell motility (GO:0001539)2.43923364
188regulation of superoxide anion generation (GO:0032928)2.43871363
189ketone body metabolic process (GO:1902224)2.43839691
190cellular anion homeostasis (GO:0030002)2.43273654
191L-methionine salvage (GO:0071267)2.42296755
192L-methionine biosynthetic process (GO:0071265)2.42296755
193amino acid salvage (GO:0043102)2.42296755
194keratinocyte differentiation (GO:0030216)2.42293381
195thyroid hormone metabolic process (GO:0042403)2.40030411
196negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39892604
197negative regulation of activin receptor signaling pathway (GO:0032926)2.39258238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.26376473
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.92521014
3ZNF274_21170338_ChIP-Seq_K562_Hela3.75073388
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.66998108
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.62551041
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.18047109
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10626553
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05425682
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.05370736
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62087555
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.52330496
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.47759822
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35193334
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24579255
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16427768
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15442481
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14105345
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13680966
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.11717805
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.04200289
21GBX2_23144817_ChIP-Seq_PC3_Human2.04117012
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.01605295
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99533676
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95162016
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.92270985
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85923811
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84082533
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77688198
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76246707
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74719810
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74492678
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.72916917
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69756890
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68781311
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67801036
36FUS_26573619_Chip-Seq_HEK293_Human1.67443341
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.65725473
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.63677620
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60785546
40IGF1R_20145208_ChIP-Seq_DFB_Human1.60563257
41TAF15_26573619_Chip-Seq_HEK293_Human1.59964495
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59940838
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.58638529
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58369145
45SOX2_20726797_ChIP-Seq_SW620_Human1.57341391
46MYC_18940864_ChIP-ChIP_HL60_Human1.56572620
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56070525
48EWS_26573619_Chip-Seq_HEK293_Human1.55890314
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.52804784
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52339022
51P53_22387025_ChIP-Seq_ESCs_Mouse1.51919320
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50584495
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50210516
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.47414630
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45308712
56ER_23166858_ChIP-Seq_MCF-7_Human1.44720694
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44615583
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.44615583
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43638747
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.42844342
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.41712604
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40263136
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40043033
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.39256859
65P300_18555785_Chip-Seq_ESCs_Mouse1.39255700
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39023623
67VDR_22108803_ChIP-Seq_LS180_Human1.38656893
68BCAT_22108803_ChIP-Seq_LS180_Human1.37910926
69* TP53_18474530_ChIP-ChIP_U2OS_Human1.37039318
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35496965
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33974086
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.33923396
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33899567
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.32817616
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32423162
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32350147
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30990295
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29723968
79PU1_27457419_Chip-Seq_LIVER_Mouse1.29555384
80SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28688974
81AR_20517297_ChIP-Seq_VCAP_Human1.28686317
82ZFX_18555785_Chip-Seq_ESCs_Mouse1.27708885
83* TP53_22573176_ChIP-Seq_HFKS_Human1.26842940
84AR_25329375_ChIP-Seq_VCAP_Human1.26621858
85NCOR_22424771_ChIP-Seq_293T_Human1.26574668
86VDR_24787735_ChIP-Seq_THP-1_Human1.26127234
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25404752
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25280561
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24511018
90* TP63_23658742_ChIP-Seq_EP156T_Human1.24506941
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23984653
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.23860878
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23641697
94NANOG_19829295_ChIP-Seq_ESCs_Human1.23538936
95SOX2_19829295_ChIP-Seq_ESCs_Human1.23538936
96CBP_20019798_ChIP-Seq_JUKART_Human1.23166612
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23166612
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22972554
99STAT1_17558387_ChIP-Seq_HELA_Human1.21588771
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21314281
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.21144590
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.20872999
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20166984
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20060351
105TCF4_22108803_ChIP-Seq_LS180_Human1.19284210
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19279187
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19174001
108HOXB7_26014856_ChIP-Seq_BT474_Human1.17482720
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16678166
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16442374
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16275833
112GATA4_25053715_ChIP-Seq_YYC3_Human1.15918191
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15767017
114EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15362225
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15162352
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.14987165
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14539814
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14251724
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13236195
120SMAD4_21799915_ChIP-Seq_A2780_Human1.13174049
121CDX2_22108803_ChIP-Seq_LS180_Human1.12755058
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12253606
123CJUN_26792858_Chip-Seq_BT549_Human1.12091412
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10898890
125MYC_19829295_ChIP-Seq_ESCs_Human1.09176725
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.08751718
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08409923
128ERA_21632823_ChIP-Seq_H3396_Human1.08352892
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07639308
130ETS1_20019798_ChIP-Seq_JURKAT_Human1.07232474
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06444260
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06093220
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.05655013
134ESR1_20079471_ChIP-ChIP_T-47D_Human1.05441108
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05169076
136P53_21459846_ChIP-Seq_SAOS-2_Human1.05155969
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.04930376
138TCF4_23295773_ChIP-Seq_U87_Human1.04012234
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03644296
140AR_21572438_ChIP-Seq_LNCaP_Human1.03005098
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02786383
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02634709
143ELK1_19687146_ChIP-ChIP_HELA_Human1.01786634
144PU_27001747_Chip-Seq_BMDM_Mouse1.00796610
145P300_19829295_ChIP-Seq_ESCs_Human0.99910193
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99664031
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.99358111
148KDM2B_26808549_Chip-Seq_REH_Human0.98558436
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97722557
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.97047599
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.96904904
152AHR_22903824_ChIP-Seq_MCF-7_Human0.96451611
153TP53_16413492_ChIP-PET_HCT116_Human0.96070532
154* ETV1_20927104_ChIP-Seq_GIST48_Human0.95263527
155STAT3_23295773_ChIP-Seq_U87_Human0.95179123
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.95090675
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94347122
158TAF2_19829295_ChIP-Seq_ESCs_Human0.93630949
159* RBPJ_21746931_ChIP-Seq_IB4_Human0.93596162
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93423727
161MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93333786
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92966413
163RUNX2_22187159_ChIP-Seq_PCA_Human0.92666359
164KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92657019
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.92292282
166* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91800964
167ARNT_22903824_ChIP-Seq_MCF-7_Human0.91483495
168VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91423025
169SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91203033
170SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91203033
171* REST_21632747_ChIP-Seq_MESCs_Mouse0.91152148
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90997445
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90800913
174* PHF8_20622853_ChIP-Seq_HELA_Human0.90698879
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.90511182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.25284235
2MP0001835_abnormal_antigen_presentation3.39260989
3MP0002148_abnormal_hypersensitivity_rea3.33548417
4MP0002234_abnormal_pharynx_morphology3.25166938
5MP0000566_synostosis3.23315754
6MP0009785_altered_susceptibility_to3.04266572
7MP0005360_urolithiasis2.84218314
8MP0003436_decreased_susceptibility_to2.81740443
9MP0010234_abnormal_vibrissa_follicle2.80869206
10MP0000427_abnormal_hair_cycle2.79647962
11MP0001666_abnormal_nutrient_absorption2.78260678
12MP0000467_abnormal_esophagus_morphology2.78154114
13MP0004885_abnormal_endolymph2.68962560
14MP0000569_abnormal_digit_pigmentation2.68645267
15MP0005451_abnormal_body_composition2.58030310
16MP0002419_abnormal_innate_immunity2.46121214
17MP0000762_abnormal_tongue_morphology2.33109622
18MP0000015_abnormal_ear_pigmentation2.25558146
19MP0002796_impaired_skin_barrier2.24300901
20MP0008875_abnormal_xenobiotic_pharmacok2.23841139
21MP0004381_abnormal_hair_follicle2.23397705
22MP0003787_abnormal_imprinting2.23193902
23MP0004043_abnormal_pH_regulation2.18807835
24MP0003011_delayed_dark_adaptation2.17221390
25MP0005025_abnormal_response_to2.15079776
26MP0009697_abnormal_copulation2.14461034
27MP0001790_abnormal_immune_system2.11598542
28MP0005387_immune_system_phenotype2.11598542
29MP0005167_abnormal_blood-brain_barrier2.00285506
30MP0003195_calcinosis1.98717828
31MP0005174_abnormal_tail_pigmentation1.98703759
32MP0002006_tumorigenesis1.98132449
33MP0001216_abnormal_epidermal_layer1.93977285
34MP0000647_abnormal_sebaceous_gland1.88466343
35MP0003724_increased_susceptibility_to1.88297251
36MP0005000_abnormal_immune_tolerance1.84134184
37MP0004782_abnormal_surfactant_physiolog1.81923101
38MP0002102_abnormal_ear_morphology1.74057432
39MP0010155_abnormal_intestine_physiology1.72875427
40MP0002452_abnormal_antigen_presenting1.72480984
41MP0000490_abnormal_crypts_of1.69552409
42MP0009764_decreased_sensitivity_to1.67724533
43MP0005551_abnormal_eye_electrophysiolog1.64014579
44MP0002095_abnormal_skin_pigmentation1.62642510
45MP0005171_absent_coat_pigmentation1.61392762
46MP0002098_abnormal_vibrissa_morphology1.61195522
47MP0010771_integument_phenotype1.58440413
48MP0005501_abnormal_skin_physiology1.57414569
49MP0009053_abnormal_anal_canal1.56331463
50MP0001533_abnormal_skeleton_physiology1.56319132
51MP0006072_abnormal_retinal_apoptosis1.54405710
52MP0004019_abnormal_vitamin_homeostasis1.52505734
53MP0000377_abnormal_hair_follicle1.49148445
54MP0008789_abnormal_olfactory_epithelium1.48649246
55MP0006082_CNS_inflammation1.48434039
56MP0008260_abnormal_autophagy1.48210797
57MP0000678_abnormal_parathyroid_gland1.47027439
58MP0005310_abnormal_salivary_gland1.46179000
59MP0002998_abnormal_bone_remodeling1.42243463
60MP0002723_abnormal_immune_serum1.40925485
61MP0002938_white_spotting1.36445543
62MP0003136_yellow_coat_color1.35810679
63MP0008872_abnormal_physiological_respon1.35682253
64MP0005166_decreased_susceptibility_to1.32585023
65MP0001188_hyperpigmentation1.31795691
66MP0001819_abnormal_immune_cell1.31591496
67MP0002876_abnormal_thyroid_physiology1.31457496
68MP0005646_abnormal_pituitary_gland1.31165048
69MP0003448_altered_tumor_morphology1.27986925
70MP0005075_abnormal_melanosome_morpholog1.27878005
71MP0004147_increased_porphyrin_level1.26074232
72MP0002420_abnormal_adaptive_immunity1.24894579
73MP0002009_preneoplasia1.24421582
74MP0002837_dystrophic_cardiac_calcinosis1.24399693
75MP0002877_abnormal_melanocyte_morpholog1.23747103
76MP0003950_abnormal_plasma_membrane1.22494545
77MP0001968_abnormal_touch/_nociception1.21588535
78MP0000383_abnormal_hair_follicle1.21576334
79MP0004133_heterotaxia1.21530306
80MP0008877_abnormal_DNA_methylation1.20967142
81MP0001853_heart_inflammation1.19789388
82MP0004142_abnormal_muscle_tone1.19083870
83MP0002138_abnormal_hepatobiliary_system1.18731507
84MP0002060_abnormal_skin_morphology1.18439805
85MP0002277_abnormal_respiratory_mucosa1.18219787
86MP0005253_abnormal_eye_physiology1.18064969
87MP0002254_reproductive_system_inflammat1.15402649
88MP0003941_abnormal_skin_development1.13293859
89MP0001879_abnormal_lymphatic_vessel1.13256355
90MP0002139_abnormal_hepatobiliary_system1.13220018
91MP0000858_altered_metastatic_potential1.13037709
92MP0001845_abnormal_inflammatory_respons1.12872754
93MP0001905_abnormal_dopamine_level1.12223441
94MP0003866_abnormal_defecation1.11385621
95MP0003718_maternal_effect1.10484890
96MP0001800_abnormal_humoral_immune1.09657281
97MP0001346_abnormal_lacrimal_gland1.08730280
98MP0001984_abnormal_olfaction1.07642144
99MP0005410_abnormal_fertilization1.07385103
100MP0003806_abnormal_nucleotide_metabolis1.06359614
101MP0002736_abnormal_nociception_after1.06152706
102MP0002638_abnormal_pupillary_reflex1.06093009
103MP0000470_abnormal_stomach_morphology1.05996315
104MP0005389_reproductive_system_phenotype1.05702912
105MP0005645_abnormal_hypothalamus_physiol1.04842527
106MP0005076_abnormal_cell_differentiation1.04050885
107MP0002282_abnormal_trachea_morphology1.03380437
108MP0005464_abnormal_platelet_physiology1.02256208
109MP0009333_abnormal_splenocyte_physiolog1.02081868
110MP0003453_abnormal_keratinocyte_physiol1.01076361
111MP0000579_abnormal_nail_morphology0.97834741
112MP0008995_early_reproductive_senescence0.96618328
113MP0001191_abnormal_skin_condition0.96331464
114MP0003755_abnormal_palate_morphology0.95710440
115MP0004264_abnormal_extraembryonic_tissu0.95368257
116MP0005671_abnormal_response_to0.94493260
117MP0002166_altered_tumor_susceptibility0.93316277
118MP0005390_skeleton_phenotype0.93109848
119MP0008775_abnormal_heart_ventricle0.92631835
120MP0001919_abnormal_reproductive_system0.91746116
121MP0003705_abnormal_hypodermis_morpholog0.91323946
122MP0008469_abnormal_protein_level0.91200042
123MP0003566_abnormal_cell_adhesion0.91182189
124MP0000367_abnormal_coat/_hair0.91129392
125MP0002653_abnormal_ependyma_morphology0.90042209
126MP0009046_muscle_twitch0.89802130
127MP0003878_abnormal_ear_physiology0.89493597
128MP0005377_hearing/vestibular/ear_phenot0.89493597
129MP0005409_darkened_coat_color0.89017572
130MP0000631_abnormal_neuroendocrine_gland0.88234874
131MP0003638_abnormal_response/metabolism_0.88003819
132MP0009745_abnormal_behavioral_response0.87071822
133MP0004510_myositis0.86593499
134MP0004742_abnormal_vestibular_system0.86103640
135MP0000538_abnormal_urinary_bladder0.85648563
136MP0003315_abnormal_perineum_morphology0.84934278
137MP0003693_abnormal_embryo_hatching0.84721623
138MP0001765_abnormal_ion_homeostasis0.84276754
139MP0009379_abnormal_foot_pigmentation0.83767056
140MP0002160_abnormal_reproductive_system0.83606228
141MP0005499_abnormal_olfactory_system0.82688796
142MP0005394_taste/olfaction_phenotype0.82688796
143MP0001986_abnormal_taste_sensitivity0.81369904
144MP0003795_abnormal_bone_structure0.81318227
145MP0002272_abnormal_nervous_system0.81235997
146MP0006292_abnormal_olfactory_placode0.80530044
147MP0000681_abnormal_thyroid_gland0.80468948
148MP0005085_abnormal_gallbladder_physiolo0.78985988
149MP0005084_abnormal_gallbladder_morpholo0.78392726
150MP0001186_pigmentation_phenotype0.76069979
151MP0001485_abnormal_pinna_reflex0.75473724
152MP0002163_abnormal_gland_morphology0.75383494
153MP0006276_abnormal_autonomic_nervous0.75008540
154MP0000613_abnormal_salivary_gland0.74891703
155MP0003690_abnormal_glial_cell0.73948524
156MP0001501_abnormal_sleep_pattern0.73440201
157MP0001663_abnormal_digestive_system0.73340344
158MP0005164_abnormal_response_to0.73063914
159MP0001177_atelectasis0.72815979
160MP0000372_irregular_coat_pigmentation0.72126026
161MP0009780_abnormal_chondrocyte_physiolo0.71662837
162MP0003937_abnormal_limbs/digits/tail_de0.71461488
163MP0010329_abnormal_lipoprotein_level0.71168047
164MP0010678_abnormal_skin_adnexa0.71159962
165MP0010386_abnormal_urinary_bladder0.71019884
166MP0000371_diluted_coat_color0.70385099
167MP0000026_abnormal_inner_ear0.70237529
168MP0001502_abnormal_circadian_rhythm0.69751693
169MP0002735_abnormal_chemical_nociception0.69371665
170MP0003786_premature_aging0.68606419
171MP0005408_hypopigmentation0.67197145
172MP0003075_altered_response_to0.66847888
173MP0002572_abnormal_emotion/affect_behav0.66770662
174MP0004215_abnormal_myocardial_fiber0.66769644
175MP0004134_abnormal_chest_morphology0.65682654

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)5.24443274
2Recurrent abscess formation (HP:0002722)4.98362564
3Eczematoid dermatitis (HP:0000976)4.92961311
4Abnormality of nail color (HP:0100643)4.90519394
5Milia (HP:0001056)4.86269316
6Fragile nails (HP:0001808)4.65121135
7Recurrent bacterial skin infections (HP:0005406)4.65113240
8Palmoplantar hyperkeratosis (HP:0000972)4.62927507
9Autoimmune thrombocytopenia (HP:0001973)4.53399526
10Palmar hyperkeratosis (HP:0010765)4.38998323
11Onycholysis (HP:0001806)4.25885660
12Alopecia of scalp (HP:0002293)3.98941926
13Abnormality of proline metabolism (HP:0010907)3.65810527
14Hydroxyprolinuria (HP:0003080)3.65810527
15Renal cortical cysts (HP:0000803)3.65431306
16Progressive sensorineural hearing impairment (HP:0000408)3.59648579
17Gingivitis (HP:0000230)3.50559944
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46477872
19Prostate neoplasm (HP:0100787)3.42789758
20Chromsome breakage (HP:0040012)3.39287431
21Basal ganglia calcification (HP:0002135)3.36620730
22Recurrent gram-negative bacterial infections (HP:0005420)3.32685108
23Congenital sensorineural hearing impairment (HP:0008527)3.32039843
24Pancreatic cysts (HP:0001737)3.31944228
25Congenital stationary night blindness (HP:0007642)3.29398872
26True hermaphroditism (HP:0010459)3.25625231
27Molar tooth sign on MRI (HP:0002419)3.22961744
28Abnormality of midbrain morphology (HP:0002418)3.22961744
29Optic neuritis (HP:0100653)3.13312043
30Retrobulbar optic neuritis (HP:0100654)3.13312043
31Pancreatic fibrosis (HP:0100732)3.09206308
32White forelock (HP:0002211)3.04007364
33Pili torti (HP:0003777)2.99769072
34Nephronophthisis (HP:0000090)2.99351629
35Orchitis (HP:0100796)2.98247252
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.97295788
37Nail dystrophy (HP:0008404)2.96830869
38Furrowed tongue (HP:0000221)2.95629089
39Oral leukoplakia (HP:0002745)2.95528271
40Abnormality of macrophages (HP:0004311)2.94832251
41Abnormal hair laboratory examination (HP:0003328)2.90513939
42Aplasia cutis congenita (HP:0001057)2.86348107
43Ileus (HP:0002595)2.83010050
44Mediastinal lymphadenopathy (HP:0100721)2.81492052
45Cheilitis (HP:0100825)2.80097356
46Joint hemorrhage (HP:0005261)2.77870012
47Right ventricular cardiomyopathy (HP:0011663)2.76817068
48Myositis (HP:0100614)2.75454336
49Amelogenesis imperfecta (HP:0000705)2.74796082
50Tetany (HP:0001281)2.71906907
51Abnormality of placental membranes (HP:0011409)2.70650297
52Amniotic constriction ring (HP:0009775)2.70650297
53Recurrent fungal infections (HP:0002841)2.66043738
54Popliteal pterygium (HP:0009756)2.65441153
55Patchy hypopigmentation of hair (HP:0011365)2.63598575
56Type II lissencephaly (HP:0007260)2.62903265
57Abnormality of the renal medulla (HP:0100957)2.60275934
58Sparse eyelashes (HP:0000653)2.57419802
59Vasculitis (HP:0002633)2.57358799
60Tubular atrophy (HP:0000092)2.56724511
61Stomach cancer (HP:0012126)2.56568207
62Recurrent skin infections (HP:0001581)2.56217638
63Progressive hearing impairment (HP:0001730)2.56115403
64Aplasia/hypoplasia of the uterus (HP:0008684)2.51842364
65Hyperphosphatemia (HP:0002905)2.47879134
66Hypoplasia of the uterus (HP:0000013)2.46911119
67Pustule (HP:0200039)2.44133474
68Abnormality of the neuromuscular junction (HP:0003398)2.42413184
69Fatigable weakness (HP:0003473)2.42413184
70Ridged nail (HP:0001807)2.42058040
71Erythroderma (HP:0001019)2.41330522
72Polydipsia (HP:0001959)2.41231327
73Abnormal drinking behavior (HP:0030082)2.41231327
74Periodontitis (HP:0000704)2.39971225
75Abnormality of secondary sexual hair (HP:0009888)2.39957572
76Abnormality of the axillary hair (HP:0100134)2.39957572
77Hypotrichosis (HP:0001006)2.35528784
78Hypoplastic labia majora (HP:0000059)2.35463432
79Parakeratosis (HP:0001036)2.34628952
80Sparse scalp hair (HP:0002209)2.31106127
81Tubulointerstitial nephritis (HP:0001970)2.27254528
82Absent/shortened dynein arms (HP:0200106)2.27145263
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.27145263
84Recurrent pneumonia (HP:0006532)2.25528249
85Abnormal rod and cone electroretinograms (HP:0008323)2.24019118
86Abnormality of incisor morphology (HP:0011063)2.22385757
87Medial flaring of the eyebrow (HP:0010747)2.22127899
88Chronic obstructive pulmonary disease (HP:0006510)2.20411473
89Obstructive lung disease (HP:0006536)2.20411473
90Abnormal blistering of the skin (HP:0008066)2.19916265
91Congenital, generalized hypertrichosis (HP:0004540)2.18335352
92Autoimmune hemolytic anemia (HP:0001890)2.18060133
93Abnormality of the labia majora (HP:0012881)2.17706426
94Increased IgE level (HP:0003212)2.17029160
95Joint swelling (HP:0001386)2.15818085
96Abnormality of the pons (HP:0007361)2.15156181
97Pigmentary retinal degeneration (HP:0001146)2.15044905
98Epidermoid cyst (HP:0200040)2.13017823
99Large for gestational age (HP:0001520)2.12504972
100Attenuation of retinal blood vessels (HP:0007843)2.10408992
101Corneal erosion (HP:0200020)2.10321212
102Abnormality of the prostate (HP:0008775)2.09456653
103Chronic hepatic failure (HP:0100626)2.08260814
104Hyperventilation (HP:0002883)2.07683170
105Abnormality of the renal collecting system (HP:0004742)2.06750759
106Nausea (HP:0002018)2.06286018
107Cerebellar dysplasia (HP:0007033)2.05229365
108Sclerocornea (HP:0000647)2.03285547
109Aplasia/Hypoplasia of the fovea (HP:0008060)2.02972260
110Hypoplasia of the fovea (HP:0007750)2.02972260
111Lip pit (HP:0100267)2.00810173
112Hypoplasia of the pons (HP:0012110)2.00174118
113Duplicated collecting system (HP:0000081)1.99485931
114Axonal loss (HP:0003447)1.97613789
115Cystic liver disease (HP:0006706)1.97400372
116Chronic mucocutaneous candidiasis (HP:0002728)1.97239330
117Recurrent cutaneous fungal infections (HP:0011370)1.97239330
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95513460
119Abnormality of alanine metabolism (HP:0010916)1.95513460
120Hyperalaninemia (HP:0003348)1.95513460
121Concave nail (HP:0001598)1.92814021
122Osteomalacia (HP:0002749)1.92701773
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.91026067
124Recurrent lower respiratory tract infections (HP:0002783)1.90289729
125Dry hair (HP:0011359)1.89379007
126Reduced antithrombin III activity (HP:0001976)1.89058913
127Acute necrotizing encephalopathy (HP:0006965)1.89010475
128Congenital ichthyosiform erythroderma (HP:0007431)1.88786926
129Abnormality of the renal cortex (HP:0011035)1.88369260
130Thick nail (HP:0001805)1.88061247
131Epiphyseal dysplasia (HP:0002656)1.87872119
132Increased CSF lactate (HP:0002490)1.87730639
133Abnormal respiratory motile cilium morphology (HP:0005938)1.87675215
134Abnormal respiratory epithelium morphology (HP:0012253)1.87675215
135Asymmetry of the thorax (HP:0001555)1.86988587
136Labial hypoplasia (HP:0000066)1.83165887
137Decreased circulating renin level (HP:0003351)1.83150960
138Eosinophilia (HP:0001880)1.83050670
139Abnormality of the thoracic spine (HP:0100711)1.82349781
140Mitochondrial inheritance (HP:0001427)1.82344126
141Conical tooth (HP:0000698)1.81927428
142Squamous cell carcinoma (HP:0002860)1.79658351
143Polyuria (HP:0000103)1.79348155
144Widely patent fontanelles and sutures (HP:0004492)1.79192058
145Petechiae (HP:0000967)1.77346918
146Thoracic kyphosis (HP:0002942)1.76810498
147Abolished electroretinogram (ERG) (HP:0000550)1.76442069
148Turricephaly (HP:0000262)1.76048644
149Esophageal atresia (HP:0002032)1.75589081
150Ectopic kidney (HP:0000086)1.75400374
151Pterygium (HP:0001059)1.75205622
152Aplasia of the musculature (HP:0100854)1.74655833
153Xerostomia (HP:0000217)1.74079742
154Decreased central vision (HP:0007663)1.74022992
155Abnormality of the nasal septum (HP:0000419)1.73919126
156Oligodontia (HP:0000677)1.73242404
157Generalized hypopigmentation of hair (HP:0011358)1.72991978
158Hypoplasia of dental enamel (HP:0006297)1.72974151
159Protruding tongue (HP:0010808)1.72439558
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.71662202
161Chronic diarrhea (HP:0002028)1.70191257
162Absent eyelashes (HP:0000561)1.70018243
163Depressed nasal tip (HP:0000437)1.69926748
164Palmoplantar keratoderma (HP:0000982)1.69852060
165Fair hair (HP:0002286)1.69717766
166Atrophic scars (HP:0001075)1.69005865
167Irregular epiphyses (HP:0010582)1.68619878
168Abnormal biliary tract physiology (HP:0012439)1.68599136
169Bile duct proliferation (HP:0001408)1.68599136
170Elevated erythrocyte sedimentation rate (HP:0003565)1.68181694
171Chorioretinal atrophy (HP:0000533)1.67979477
172Pendular nystagmus (HP:0012043)1.67651313
173Curly hair (HP:0002212)1.67550864
174Progressive macrocephaly (HP:0004481)1.67550795
175Prolonged neonatal jaundice (HP:0006579)1.66218281
176Anorexia (HP:0002039)1.65910736
177Alveolar cell carcinoma (HP:0006519)1.65516181
178Proximal tubulopathy (HP:0000114)1.63437746
179Distal lower limb muscle weakness (HP:0009053)1.63275833
180Recurrent viral infections (HP:0004429)1.62925150
181Woolly hair (HP:0002224)1.62847216
182Hemoptysis (HP:0002105)1.62667198
183Meningitis (HP:0001287)1.62446764
184Porencephaly (HP:0002132)1.62199027
185Arthralgia (HP:0002829)1.62126395
186Abnormality of male internal genitalia (HP:0000022)1.61590995
187Pulmonary infiltrates (HP:0002113)1.61229879
188Abnormal hair whorl (HP:0010721)1.59303896
189Cellulitis (HP:0100658)1.59227317
190Keratoconjunctivitis sicca (HP:0001097)1.58628920
191Bifid uvula (HP:0000193)1.58581249
192Abnormal platelet volume (HP:0011876)1.58566446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.81410129
2IRAK35.18264584
3MAP3K143.90491364
4TIE13.41859331
5RIPK42.88535077
6MST42.71283318
7MAP4K22.68360853
8TLK12.59956210
9WNK42.43930578
10TGFBR12.31549890
11INSRR2.12112413
12MAPKAPK32.05408546
13MET1.99135370
14SRPK11.95821798
15WNK31.95188621
16TAOK31.91240235
17TRPM71.84875715
18PINK11.76000350
19PIM21.75593898
20ERBB31.72060122
21FRK1.71720276
22BMX1.70195357
23STK391.67835095
24YES11.66321988
25EPHB21.64442116
26MST1R1.61230402
27EIF2AK21.60953710
28ZAK1.57631975
29MAPK151.56275927
30PBK1.53171068
31TRIM281.51617984
32ACVR1B1.50582466
33TBK11.45019771
34SIK31.41613880
35MAP3K31.41111471
36AKT31.40646923
37OXSR11.38037470
38GRK11.35952151
39FER1.32618869
40NLK1.30748163
41CASK1.26516506
42TXK1.26044581
43IRAK21.24145626
44ADRBK11.23765126
45TEC1.22887535
46CSNK1G31.22680445
47BMPR21.21083565
48PHKG11.21005835
49PHKG21.21005835
50NME21.19671989
51EPHA21.19184200
52BLK1.18610031
53EPHA31.18464517
54NME11.17829827
55BCR1.17682270
56STK38L1.14504978
57CSNK1G21.11714523
58MAPKAPK51.10730846
59MUSK1.10234659
60EIF2AK31.08070977
61CSNK1G11.07841129
62PRKG21.07366577
63IKBKE1.05493362
64CSNK1A1L1.03122011
65STK161.03056181
66IRAK11.02978808
67IKBKB1.01545140
68PIK3CG1.00707452
69VRK20.99892910
70PRPF4B0.98855301
71PTK2B0.97966813
72PIM10.95516611
73FLT30.94564294
74PAK30.93282522
75VRK10.93115538
76TNIK0.92256743
77STK240.91555871
78MAP2K60.90699842
79GSK3A0.90363405
80DYRK20.88983148
81NUAK10.85515878
82JAK30.83420311
83DMPK0.82269294
84PNCK0.80260472
85TYK20.79238204
86MAP3K20.78773231
87CLK10.77958266
88MAPK130.77510628
89NEK90.77164531
90PIK3CA0.76182130
91CAMK1D0.76027055
92CSK0.75859204
93MAP3K40.74981368
94PRKCG0.74958722
95MARK10.74915331
96BMPR1B0.72380275
97NEK60.71876207
98PTK60.70226115
99JAK10.69121185
100STK100.68572497
101CHUK0.67733156
102GRK50.67132119
103GRK70.67124841
104MARK30.66965690
105LYN0.66949736
106MAP2K20.64860774
107MAP2K70.62631935
108TGFBR20.60556961
109ERBB40.60475424
110MAP4K10.60227819
111CSNK1A10.58842503
112ALK0.58730755
113ABL10.57288065
114PRKCE0.53623126
115ABL20.52466596
116MKNK20.52428303
117PRKCI0.51365556
118PRKCD0.50762530
119ADRBK20.50672141
120TSSK60.49967945
121LMTK20.49431822
122RPS6KA50.48371628
123SGK20.47893103
124DAPK20.46959765
125HCK0.46802143
126LIMK10.46737976
127EPHB10.46540549
128TNK20.45251744
129JAK20.45138425
130MATK0.40486059
131BCKDK0.39902730
132MAP2K30.39480398
133PRKACA0.38439463
134MAPKAPK20.38356337
135CAMKK20.37576970
136STK40.37013602
137FGFR20.36689547
138PDK20.36363568
139PLK20.36006955
140CDK60.35370460
141CDK30.35058442
142SYK0.34943730
143IGF1R0.34885514
144EPHA40.34391377
145BTK0.34040838
146TAF10.33957271
147CAMK2A0.33890018
148PLK30.33831684
149NEK10.32883921
150DDR20.32316991
151PRKCQ0.31764648
152PRKCA0.30840148
153MAP3K120.30761994
154LATS10.30645271
155GRK60.29851855
156ERBB20.29747762
157STK30.29471344
158PRKCZ0.29059422
159MKNK10.27637736
160SGK10.27441757
161AKT10.26234583
162EGFR0.24914485
163CSNK1D0.24148857
164MAP3K90.23501007
165HIPK20.22916249
166RPS6KA60.22301156

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049772.93782755
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.93574648
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.83660659
4Linoleic acid metabolism_Homo sapiens_hsa005912.81494006
5Phototransduction_Homo sapiens_hsa047442.77979583
6Oxidative phosphorylation_Homo sapiens_hsa001902.73638150
7Renin-angiotensin system_Homo sapiens_hsa046142.59037005
8Caffeine metabolism_Homo sapiens_hsa002322.48515385
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.42443234
10Leishmaniasis_Homo sapiens_hsa051402.36659288
11Mineral absorption_Homo sapiens_hsa049782.35662204
12Protein export_Homo sapiens_hsa030602.34473649
13Nitrogen metabolism_Homo sapiens_hsa009102.28144532
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14969020
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.11288200
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08557707
17Parkinsons disease_Homo sapiens_hsa050122.02818655
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99522335
19African trypanosomiasis_Homo sapiens_hsa051431.98360053
20Graft-versus-host disease_Homo sapiens_hsa053321.96344433
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.89165018
22RNA polymerase_Homo sapiens_hsa030201.87887852
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87865488
24Malaria_Homo sapiens_hsa051441.86245590
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84746031
26Fat digestion and absorption_Homo sapiens_hsa049751.84260012
27Sphingolipid metabolism_Homo sapiens_hsa006001.80481365
28Butanoate metabolism_Homo sapiens_hsa006501.79692814
29Pertussis_Homo sapiens_hsa051331.74273445
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70955170
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.70813634
32Sulfur metabolism_Homo sapiens_hsa009201.70690644
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62587784
34Staphylococcus aureus infection_Homo sapiens_hsa051501.61756818
35Tryptophan metabolism_Homo sapiens_hsa003801.60726033
36Basal transcription factors_Homo sapiens_hsa030221.58339763
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57020644
38Legionellosis_Homo sapiens_hsa051341.55820383
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51652306
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51037678
41Rheumatoid arthritis_Homo sapiens_hsa053231.50645317
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49453860
43Measles_Homo sapiens_hsa051621.49195915
44Starch and sucrose metabolism_Homo sapiens_hsa005001.48743954
45Huntingtons disease_Homo sapiens_hsa050161.48710781
46Alzheimers disease_Homo sapiens_hsa050101.46733385
47TNF signaling pathway_Homo sapiens_hsa046681.46483769
48Tuberculosis_Homo sapiens_hsa051521.46199084
49Selenocompound metabolism_Homo sapiens_hsa004501.44067202
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39142912
51Salmonella infection_Homo sapiens_hsa051321.38743743
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37956813
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30549995
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30230218
55Steroid biosynthesis_Homo sapiens_hsa001001.29285128
56Influenza A_Homo sapiens_hsa051641.28934397
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28859163
58Sulfur relay system_Homo sapiens_hsa041221.24663781
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.22911439
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21011252
61Histidine metabolism_Homo sapiens_hsa003401.20978732
62Phagosome_Homo sapiens_hsa041451.19479913
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16305026
64Protein digestion and absorption_Homo sapiens_hsa049741.16148304
65Peroxisome_Homo sapiens_hsa041461.15230910
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14705333
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13412144
68Toxoplasmosis_Homo sapiens_hsa051451.13234737
69Osteoclast differentiation_Homo sapiens_hsa043801.13207190
70Herpes simplex infection_Homo sapiens_hsa051681.12167754
71Cardiac muscle contraction_Homo sapiens_hsa042601.12080830
72Nicotine addiction_Homo sapiens_hsa050331.11932031
73Hematopoietic cell lineage_Homo sapiens_hsa046401.11102679
74Homologous recombination_Homo sapiens_hsa034401.07612619
75Allograft rejection_Homo sapiens_hsa053301.04871422
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04164067
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03532315
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.03199517
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01497693
80p53 signaling pathway_Homo sapiens_hsa041151.00268045
81Hepatitis C_Homo sapiens_hsa051601.00063257
82Arachidonic acid metabolism_Homo sapiens_hsa005900.99279795
83Proteasome_Homo sapiens_hsa030500.98700579
84Collecting duct acid secretion_Homo sapiens_hsa049660.95961517
85Propanoate metabolism_Homo sapiens_hsa006400.95874193
86One carbon pool by folate_Homo sapiens_hsa006700.95222948
87Taste transduction_Homo sapiens_hsa047420.94932146
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.94782608
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94467226
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93851616
91Folate biosynthesis_Homo sapiens_hsa007900.92619760
92Chemokine signaling pathway_Homo sapiens_hsa040620.90488315
93Ribosome_Homo sapiens_hsa030100.89360016
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.88727555
95Metabolic pathways_Homo sapiens_hsa011000.88260778
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85709796
97Glycerolipid metabolism_Homo sapiens_hsa005610.85700671
98ABC transporters_Homo sapiens_hsa020100.84846863
99Regulation of autophagy_Homo sapiens_hsa041400.84270559
100Olfactory transduction_Homo sapiens_hsa047400.82874244
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82218192
102Vitamin B6 metabolism_Homo sapiens_hsa007500.80190703
103Asthma_Homo sapiens_hsa053100.80079405
104beta-Alanine metabolism_Homo sapiens_hsa004100.79874622
105RNA degradation_Homo sapiens_hsa030180.79407116
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.79120111
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78821423
108Serotonergic synapse_Homo sapiens_hsa047260.76366771
109Apoptosis_Homo sapiens_hsa042100.75991844
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72907675
111Glutathione metabolism_Homo sapiens_hsa004800.70688723
112Fanconi anemia pathway_Homo sapiens_hsa034600.68915820
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66689062
114Pyrimidine metabolism_Homo sapiens_hsa002400.66475835
115Autoimmune thyroid disease_Homo sapiens_hsa053200.64510597
116Other glycan degradation_Homo sapiens_hsa005110.64346556
117Arginine and proline metabolism_Homo sapiens_hsa003300.63783524
118Fatty acid elongation_Homo sapiens_hsa000620.62199242
119Retinol metabolism_Homo sapiens_hsa008300.60882034
120Salivary secretion_Homo sapiens_hsa049700.59980221
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58239094
122Insulin secretion_Homo sapiens_hsa049110.57618066
123Purine metabolism_Homo sapiens_hsa002300.57373663
124Prostate cancer_Homo sapiens_hsa052150.56767252
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.55519669
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.55353249
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54509251
128Hepatitis B_Homo sapiens_hsa051610.53286265
129Shigellosis_Homo sapiens_hsa051310.53204344
130Fatty acid degradation_Homo sapiens_hsa000710.52634215
131Chemical carcinogenesis_Homo sapiens_hsa052040.51065795
132Type I diabetes mellitus_Homo sapiens_hsa049400.50942918
133Small cell lung cancer_Homo sapiens_hsa052220.50699108
134Axon guidance_Homo sapiens_hsa043600.48697823
135Lysosome_Homo sapiens_hsa041420.47766398
136Platelet activation_Homo sapiens_hsa046110.47565039
137Hedgehog signaling pathway_Homo sapiens_hsa043400.47201982
138Galactose metabolism_Homo sapiens_hsa000520.47138439
139Tyrosine metabolism_Homo sapiens_hsa003500.46627618
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.46381619
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45275347
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42746516
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41696360
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.41375350
145Glutamatergic synapse_Homo sapiens_hsa047240.41293454
146Inositol phosphate metabolism_Homo sapiens_hsa005620.40725651
147Circadian rhythm_Homo sapiens_hsa047100.40722901
148Primary immunodeficiency_Homo sapiens_hsa053400.40719342
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39865853
150Epstein-Barr virus infection_Homo sapiens_hsa051690.39801985
151Melanoma_Homo sapiens_hsa052180.39455266
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37853009
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.37310786
154GABAergic synapse_Homo sapiens_hsa047270.36890309
155Amoebiasis_Homo sapiens_hsa051460.36664745
156Acute myeloid leukemia_Homo sapiens_hsa052210.35425167
157Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35357300
158ECM-receptor interaction_Homo sapiens_hsa045120.35052891
159B cell receptor signaling pathway_Homo sapiens_hsa046620.34775403
160Circadian entrainment_Homo sapiens_hsa047130.34588438
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33192130
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33107839
163Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32011742
164Ether lipid metabolism_Homo sapiens_hsa005650.31685014
165Adherens junction_Homo sapiens_hsa045200.31600048
166Viral myocarditis_Homo sapiens_hsa054160.30833277
167Prolactin signaling pathway_Homo sapiens_hsa049170.30259467
168Ovarian steroidogenesis_Homo sapiens_hsa049130.29751395

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