HES5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocardial cushion morphogenesis (GO:0003203)9.78714825
2heart valve formation (GO:0003188)9.54434367
3mesenchyme morphogenesis (GO:0072132)7.64922032
4neuron projection extension involved in neuron projection guidance (GO:1902284)7.40197020
5axon extension involved in axon guidance (GO:0048846)7.40197020
6epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)7.14704804
7cell migration involved in heart development (GO:0060973)7.02779289
8venous blood vessel morphogenesis (GO:0048845)6.91977847
9Notch signaling involved in heart development (GO:0061314)6.53250079
10lung epithelium development (GO:0060428)6.46652975
11regulation of somitogenesis (GO:0014807)6.35466971
12epithelial cell fate commitment (GO:0072148)6.26277073
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.19667925
14ventricular trabecula myocardium morphogenesis (GO:0003222)6.19482765
15viral transcription (GO:0019083)6.18181662
16epithelial cell differentiation involved in prostate gland development (GO:0060742)6.06956338
17heart trabecula morphogenesis (GO:0061384)5.94736706
18translational termination (GO:0006415)5.92815849
19ribosomal small subunit assembly (GO:0000028)5.88275937
20* neuronal stem cell maintenance (GO:0097150)5.60499610
21negative regulation of axon guidance (GO:1902668)5.45123341
22left/right axis specification (GO:0070986)5.44080387
23regulation of extracellular matrix organization (GO:1903053)5.44039165
24positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.30890894
25dopaminergic neuron differentiation (GO:0071542)5.28364235
26regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.24278311
27cell proliferation in forebrain (GO:0021846)5.12307608
28paraxial mesoderm development (GO:0048339)5.12279949
29maturation of SSU-rRNA (GO:0030490)5.12064586
30ribosomal small subunit biogenesis (GO:0042274)5.07227329
31* negative regulation of oligodendrocyte differentiation (GO:0048715)5.04825971
32lens fiber cell development (GO:0070307)5.01845736
33cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.95954225
34negative regulation of axon extension involved in axon guidance (GO:0048843)4.95244203
35eye photoreceptor cell differentiation (GO:0001754)4.92733753
36photoreceptor cell differentiation (GO:0046530)4.92733753
37negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.90279379
38trabecula morphogenesis (GO:0061383)4.85170505
39negative regulation of myoblast differentiation (GO:0045662)4.82442114
40tongue development (GO:0043586)4.82130595
41behavioral response to nicotine (GO:0035095)4.77996529
42translational elongation (GO:0006414)4.73278627
43* negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.68549568
44coronary vasculature morphogenesis (GO:0060977)4.64984515
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64737590
46positive regulation of astrocyte differentiation (GO:0048711)4.64379771
47cotranslational protein targeting to membrane (GO:0006613)4.64021195
48protein targeting to ER (GO:0045047)4.57603301
49atrioventricular valve morphogenesis (GO:0003181)4.53607771
50collecting duct development (GO:0072044)4.52126402
51cellular protein complex disassembly (GO:0043624)4.50327577
52viral life cycle (GO:0019058)4.49540715
53negative regulation of glial cell proliferation (GO:0060253)4.45066330
54cardiac left ventricle morphogenesis (GO:0003214)4.43290007
55establishment of protein localization to endoplasmic reticulum (GO:0072599)4.41264443
56ventricular septum morphogenesis (GO:0060412)4.39143228
57notochord development (GO:0030903)4.36455533
58dendritic spine morphogenesis (GO:0060997)4.35169624
59negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.33443822
60protein localization to endoplasmic reticulum (GO:0070972)4.26562724
61forebrain neuron differentiation (GO:0021879)4.25849882
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.23256153
63establishment of planar polarity (GO:0001736)4.22344963
64establishment of tissue polarity (GO:0007164)4.22344963
65establishment of nucleus localization (GO:0040023)4.20474392
66lateral sprouting from an epithelium (GO:0060601)4.19995929
67establishment of protein localization to mitochondrial membrane (GO:0090151)4.17927796
68limb bud formation (GO:0060174)4.15531234
69retinal ganglion cell axon guidance (GO:0031290)4.06633613
70epithelial cilium movement (GO:0003351)4.06268850
71otic vesicle formation (GO:0030916)4.03236847
72protein complex disassembly (GO:0043241)3.94838728
73negative regulation of chondrocyte differentiation (GO:0032331)3.92900041
74nephron tubule development (GO:0072080)3.91655122
75ovulation cycle (GO:0042698)3.90362503
76appendage development (GO:0048736)3.88709066
77limb development (GO:0060173)3.88709066
78* negative regulation of glial cell differentiation (GO:0045686)3.86582355
79regulation of mesenchymal cell apoptotic process (GO:2001053)3.84757950
80regulation of endothelial cell chemotaxis (GO:2001026)3.82625092
81nonmotile primary cilium assembly (GO:0035058)3.82584355
82negative regulation of myotube differentiation (GO:0010832)3.79245652
83positive regulation of extracellular matrix organization (GO:1903055)3.76074635
84axonemal dynein complex assembly (GO:0070286)3.74724912
85midbrain development (GO:0030901)3.73484791
86cell surface receptor signaling pathway involved in heart development (GO:0061311)3.70915054
87macromolecular complex disassembly (GO:0032984)3.70881857
88hypothalamus development (GO:0021854)3.70407174
89digestive tract morphogenesis (GO:0048546)3.70019159
90* regulation of astrocyte differentiation (GO:0048710)3.69736258
91postsynaptic membrane organization (GO:0001941)3.69457888
92* central nervous system myelination (GO:0022010)3.66004025
93* axon ensheathment in central nervous system (GO:0032291)3.66004025
94somite development (GO:0061053)3.65733280
95G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.64504991
96forebrain morphogenesis (GO:0048853)3.58388054
97striated muscle cell proliferation (GO:0014855)3.58162092
98* negative regulation of astrocyte differentiation (GO:0048712)3.57283714
99presynaptic membrane assembly (GO:0097105)3.55801562
100cilium movement (GO:0003341)3.55102907
101* positive regulation of Notch signaling pathway (GO:0045747)3.55059508
102positive regulation of vascular permeability (GO:0043117)3.53530535
103negative regulation of chemotaxis (GO:0050922)3.52465305
104midgut development (GO:0007494)3.51665337
105renal tubule development (GO:0061326)3.51490186
106heart valve morphogenesis (GO:0003179)3.50267792
107cardiovascular system development (GO:0072358)3.48376196
108retinal rod cell development (GO:0046548)3.48015319
109regulation of axon guidance (GO:1902667)3.47959066
110peptidyl-arginine omega-N-methylation (GO:0035247)3.47050473
111intraciliary transport (GO:0042073)3.43717317
112mating behavior (GO:0007617)3.43496600
113nodal signaling pathway (GO:0038092)3.41701717
114translational initiation (GO:0006413)3.41604526
115type B pancreatic cell development (GO:0003323)3.40874915
116* pattern specification involved in kidney development (GO:0061004)3.40514013
117Sertoli cell development (GO:0060009)3.38081336
118negative regulation of axon extension (GO:0030517)3.36266670
119* regulation of oligodendrocyte differentiation (GO:0048713)3.34277414
120positive regulation of male gonad development (GO:2000020)3.33856786
121spinal cord development (GO:0021510)3.33689929
122substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.32865558
123substrate-independent telencephalic tangential migration (GO:0021826)3.32865558
124axonal fasciculation (GO:0007413)3.30932654
125cochlea morphogenesis (GO:0090103)3.29881950
126nephron tubule formation (GO:0072079)3.28965476
127somatic stem cell division (GO:0048103)3.28516234
128cardiac ventricle formation (GO:0003211)3.26223712
129* positive regulation of BMP signaling pathway (GO:0030513)3.25584176
130planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23313035
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21782692
132protein targeting to membrane (GO:0006612)3.16209788
133response to follicle-stimulating hormone (GO:0032354)3.14695580
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14074257
135endothelial cell differentiation (GO:0045446)3.12518991
136regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.12033401
137embryonic hindlimb morphogenesis (GO:0035116)3.11252048
138protein neddylation (GO:0045116)3.10268646
139pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09814795
140negative chemotaxis (GO:0050919)3.09226731
141* neuron fate determination (GO:0048664)3.08979564
142chondrocyte proliferation (GO:0035988)3.08892464
143pyrimidine nucleobase catabolic process (GO:0006208)3.08507033
144Notch receptor processing (GO:0007220)3.08062859
145embryonic camera-type eye development (GO:0031076)3.07085590
146peptidyl-arginine methylation (GO:0018216)3.05890280
147peptidyl-arginine N-methylation (GO:0035246)3.05890280
148response to auditory stimulus (GO:0010996)3.04706113
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04566601
150negative regulation of anoikis (GO:2000811)3.03333757
151positive regulation of keratinocyte differentiation (GO:0045618)3.03036093
152regulation of non-canonical Wnt signaling pathway (GO:2000050)3.01547115
153positive regulation of neuroblast proliferation (GO:0002052)3.01353144
154presynaptic membrane organization (GO:0097090)2.99825311
155fucose catabolic process (GO:0019317)2.96893350
156L-fucose metabolic process (GO:0042354)2.96893350
157L-fucose catabolic process (GO:0042355)2.96893350
158chaperone-mediated protein complex assembly (GO:0051131)2.94154117
159cerebral cortex radially oriented cell migration (GO:0021799)2.89240744
160centriole replication (GO:0007099)2.88453257
161neural precursor cell proliferation (GO:0061351)2.86055389
162nuclear-transcribed mRNA catabolic process (GO:0000956)2.85991813
163pyrimidine nucleotide catabolic process (GO:0006244)2.85621533
164* segment specification (GO:0007379)2.84527315
165mRNA catabolic process (GO:0006402)2.80732282
166negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.79820822
167cell-cell signaling involved in cell fate commitment (GO:0045168)2.79541909
168pituitary gland development (GO:0021983)2.78341162
169photoreceptor cell development (GO:0042461)2.74819946
170L-serine metabolic process (GO:0006563)2.74423590
171olfactory bulb development (GO:0021772)2.73840398
172* smoothened signaling pathway (GO:0007224)2.73217495
173short-term memory (GO:0007614)2.69432342
174water-soluble vitamin biosynthetic process (GO:0042364)2.66429605
175regulation of cilium movement (GO:0003352)2.66112984
176camera-type eye morphogenesis (GO:0048593)2.65888851
177neuron fate commitment (GO:0048663)2.62775934
178regulation of microtubule-based movement (GO:0060632)2.58029899
179cilium organization (GO:0044782)2.57292684
180cerebral cortex neuron differentiation (GO:0021895)2.57221705
181cilium morphogenesis (GO:0060271)2.56925751
182cranial nerve development (GO:0021545)2.55001002
183regulation of Rac GTPase activity (GO:0032314)2.53851582
184cilium assembly (GO:0042384)2.52833864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.64740668
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.52012405
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.78003548
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.22192262
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.97069696
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96205062
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96205062
8* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.95662458
9* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.92566037
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.87068639
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.78159448
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69278560
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68931239
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.66598074
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66039422
16* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.65685349
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64402416
18TP53_20018659_ChIP-ChIP_R1E_Mouse2.57697082
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54010067
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48471334
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.47378923
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44899171
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37169645
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.36004708
25EZH2_22144423_ChIP-Seq_EOC_Human2.33332106
26KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.27729590
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20320771
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19640523
29* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18892465
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17873661
31RING1B_27294783_Chip-Seq_ESCs_Mouse2.15432139
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09060278
33* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07268997
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99591821
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99553582
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.94542926
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93890377
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91248407
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87221697
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86011044
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77551662
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73750461
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72955949
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67466716
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66861969
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.66467531
47ZNF274_21170338_ChIP-Seq_K562_Hela1.66449286
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.66208897
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64942193
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62671850
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60558123
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57642232
53IRF1_19129219_ChIP-ChIP_H3396_Human1.57350611
54DROSHA_22980978_ChIP-Seq_HELA_Human1.56876214
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53575293
56GBX2_23144817_ChIP-Seq_PC3_Human1.48215710
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47143763
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47058698
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46103995
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.45619834
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44402380
62* XRN2_22483619_ChIP-Seq_HELA_Human1.42708953
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42129987
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.40242298
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39381793
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38223233
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35292239
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35187915
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34202218
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33777826
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33777826
72FUS_26573619_Chip-Seq_HEK293_Human1.31217192
73REST_21632747_ChIP-Seq_MESCs_Mouse1.29714743
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29439058
75ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28844201
76* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.28099761
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.26189607
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24374988
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23946880
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23212795
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23002792
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22580650
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22119331
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21934715
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.18139848
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17549725
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16071013
88MYC_18940864_ChIP-ChIP_HL60_Human1.16020632
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15370892
90VDR_22108803_ChIP-Seq_LS180_Human1.14798233
91SOX3_22085726_ChIP-Seq_NPCs_Mouse1.14688889
92* KDM2B_26808549_Chip-Seq_K562_Human1.14609399
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12348561
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12199895
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11886940
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11716884
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11502139
98AR_21572438_ChIP-Seq_LNCaP_Human1.11108776
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11051131
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.10591487
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10166493
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09635638
103LXR_22292898_ChIP-Seq_THP-1_Human1.08653859
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07526703
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06338071
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06333308
107RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04655289
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03705791
109VDR_21846776_ChIP-Seq_THP-1_Human1.01118063
110EWS_26573619_Chip-Seq_HEK293_Human1.00968374
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00227431
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00187299
113P300_19829295_ChIP-Seq_ESCs_Human0.99570130
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99360283
115TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99216176
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99196775
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98535092
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98477308
119RNF2_27304074_Chip-Seq_NSC_Mouse0.98446303
120* CTCF_27219007_Chip-Seq_Bcells_Human0.97081330
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95075710
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94314738
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.94024785
124SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94017557
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93811566
126CIITA_25753668_ChIP-Seq_RAJI_Human0.92644610
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91538362
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91302793
129WDR5_24793694_ChIP-Seq_LNCAP_Human0.90945824
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.90693394
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.89626417
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89384516
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.89196702
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88774057
135IGF1R_20145208_ChIP-Seq_DFB_Human0.88133644
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87600970
137SOX9_26525672_Chip-Seq_HEART_Mouse0.85495313
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84403990
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83318813
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.83094017
141MYC_22102868_ChIP-Seq_BL_Human0.83066370
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82408624
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82134734
144CBP_20019798_ChIP-Seq_JUKART_Human0.81459369
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81459369
146* SMAD3_21741376_ChIP-Seq_ESCs_Human0.80982157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.33104607
2MP0010030_abnormal_orbit_morphology6.20314659
3MP0003136_yellow_coat_color5.41106284
4MP0002653_abnormal_ependyma_morphology4.56127566
5MP0009379_abnormal_foot_pigmentation4.51131535
6MP0006292_abnormal_olfactory_placode4.24191145
7MP0003880_abnormal_central_pattern4.17188934
8MP0003315_abnormal_perineum_morphology3.98815939
9MP0002102_abnormal_ear_morphology3.31485284
10MP0009780_abnormal_chondrocyte_physiolo3.24542448
11MP0005423_abnormal_somatic_nervous2.97828648
12MP0001529_abnormal_vocalization2.89205916
13MP0005257_abnormal_intraocular_pressure2.86662036
14MP0000537_abnormal_urethra_morphology2.86042900
15MP0008961_abnormal_basal_metabolism2.82793820
16MP0002638_abnormal_pupillary_reflex2.79233133
17MP0002249_abnormal_larynx_morphology2.62810792
18MP0004133_heterotaxia2.59975867
19MP0004885_abnormal_endolymph2.59780840
20MP0000569_abnormal_digit_pigmentation2.56812271
21MP0000778_abnormal_nervous_system2.51865198
22MP0001485_abnormal_pinna_reflex2.47737159
23MP0002282_abnormal_trachea_morphology2.45503479
24MP0003878_abnormal_ear_physiology2.40582906
25MP0005377_hearing/vestibular/ear_phenot2.40582906
26MP0005187_abnormal_penis_morphology2.34274041
27MP0003787_abnormal_imprinting2.33464129
28MP0004381_abnormal_hair_follicle2.26376022
29MP0003183_abnormal_peptide_metabolism2.25072986
30MP0000647_abnormal_sebaceous_gland2.14598552
31MP0002837_dystrophic_cardiac_calcinosis2.01857409
32MP0006276_abnormal_autonomic_nervous2.00916466
33MP0000049_abnormal_middle_ear2.00433240
34MP0002751_abnormal_autonomic_nervous1.91836865
35MP0003121_genomic_imprinting1.80419032
36MP0008995_early_reproductive_senescence1.75071374
37MP0003283_abnormal_digestive_organ1.72496319
38MP0004142_abnormal_muscle_tone1.66608119
39MP0002089_abnormal_postnatal_growth/wei1.59845379
40MP0003123_paternal_imprinting1.54595334
41MP0006072_abnormal_retinal_apoptosis1.46926082
42MP0002092_abnormal_eye_morphology1.45062030
43MP0001299_abnormal_eye_distance/1.44861494
44MP0005248_abnormal_Harderian_gland1.44778116
45* MP0005195_abnormal_posterior_eye1.42971682
46MP0000428_abnormal_craniofacial_morphol1.41851104
47MP0002697_abnormal_eye_size1.38504554
48MP0003137_abnormal_impulse_conducting1.35095610
49MP0009053_abnormal_anal_canal1.34966318
50MP0001963_abnormal_hearing_physiology1.34393165
51MP0002095_abnormal_skin_pigmentation1.27522046
52MP0003861_abnormal_nervous_system1.27438641
53MP0003115_abnormal_respiratory_system1.24954705
54MP0001984_abnormal_olfaction1.23527088
55MP0002572_abnormal_emotion/affect_behav1.23326618
56MP0005551_abnormal_eye_electrophysiolog1.22967204
57MP0001293_anophthalmia1.21615454
58MP0008789_abnormal_olfactory_epithelium1.20354859
59MP0005646_abnormal_pituitary_gland1.14821838
60MP0001502_abnormal_circadian_rhythm1.12631328
61MP0002932_abnormal_joint_morphology1.12506655
62MP0004859_abnormal_synaptic_plasticity1.11659403
63MP0005253_abnormal_eye_physiology1.11592793
64MP0000579_abnormal_nail_morphology1.11083100
65* MP0000026_abnormal_inner_ear1.11068667
66MP0000955_abnormal_spinal_cord1.10081815
67MP0005174_abnormal_tail_pigmentation1.08086160
68MP0002938_white_spotting1.07318699
69MP0002234_abnormal_pharynx_morphology1.06608480
70MP0003890_abnormal_embryonic-extraembry1.06166053
71MP0002163_abnormal_gland_morphology1.05467952
72MP0000631_abnormal_neuroendocrine_gland1.05239320
73MP0005220_abnormal_exocrine_pancreas1.03527300
74MP0005394_taste/olfaction_phenotype1.03371376
75MP0005499_abnormal_olfactory_system1.03371376
76MP0000538_abnormal_urinary_bladder1.02101215
77MP0002116_abnormal_craniofacial_bone1.01491512
78MP0003938_abnormal_ear_development1.00931560
79MP0002067_abnormal_sensory_capabilities0.99534275
80MP0001286_abnormal_eye_development0.99123408
81MP0002272_abnormal_nervous_system0.99029736
82MP0005084_abnormal_gallbladder_morpholo0.98897031
83MP0009745_abnormal_behavioral_response0.98786484
84MP0008007_abnormal_cellular_replicative0.97870113
85MP0000467_abnormal_esophagus_morphology0.95835396
86MP0005171_absent_coat_pigmentation0.95285518
87MP0002233_abnormal_nose_morphology0.94687155
88MP0001324_abnormal_eye_pigmentation0.94609332
89MP0008932_abnormal_embryonic_tissue0.93738930
90MP0005197_abnormal_uvea_morphology0.93118539
91MP0000163_abnormal_cartilage_morphology0.91536107
92MP0002152_abnormal_brain_morphology0.90567536
93MP0005508_abnormal_skeleton_morphology0.89935222
94MP0001486_abnormal_startle_reflex0.89019299
95MP0005391_vision/eye_phenotype0.89005104
96MP0003755_abnormal_palate_morphology0.88355849
97MP0000371_diluted_coat_color0.85515207
98MP0003937_abnormal_limbs/digits/tail_de0.85085053
99MP0000733_abnormal_muscle_development0.84107322
100MP0002557_abnormal_social/conspecific_i0.83815076
101MP0002882_abnormal_neuron_morphology0.83510796
102MP0002734_abnormal_mechanical_nocicepti0.82857727
103MP0002736_abnormal_nociception_after0.82574689
104MP0000762_abnormal_tongue_morphology0.82551671
105MP0009250_abnormal_appendicular_skeleto0.80943976
106MP0002928_abnormal_bile_duct0.79143748
107MP0001346_abnormal_lacrimal_gland0.78403051
108MP0001970_abnormal_pain_threshold0.74682936
109MP0000372_irregular_coat_pigmentation0.74097478
110MP0002733_abnormal_thermal_nociception0.72638272
111MP0004134_abnormal_chest_morphology0.71483846
112MP0008877_abnormal_DNA_methylation0.70839521
113MP0000534_abnormal_ureter_morphology0.70760860
114MP0002084_abnormal_developmental_patter0.68817159
115MP0002184_abnormal_innervation0.67542142
116MP0009384_cardiac_valve_regurgitation0.67209554
117MP0001270_distended_abdomen0.66354475
118MP0003385_abnormal_body_wall0.66338498
119MP0002111_abnormal_tail_morphology0.66007809
120MP0002085_abnormal_embryonic_tissue0.64864072
121MP0001968_abnormal_touch/_nociception0.64699101
122MP0002277_abnormal_respiratory_mucosa0.64633276
123MP0004858_abnormal_nervous_system0.64040900
124MP0003879_abnormal_hair_cell0.63545239
125* MP0002752_abnormal_somatic_nervous0.62943517
126MP0003635_abnormal_synaptic_transmissio0.62340759
127MP0003122_maternal_imprinting0.62118682
128MP0003329_amyloid_beta_deposits0.61826086
129MP0003119_abnormal_digestive_system0.61587751
130MP0001958_emphysema0.61472630
131MP0005503_abnormal_tendon_morphology0.60837217
132MP0002064_seizures0.60298640
133MP0002063_abnormal_learning/memory/cond0.59265114
134MP0001944_abnormal_pancreas_morphology0.59075486
135MP0003942_abnormal_urinary_system0.58996305
136MP0001943_abnormal_respiration0.57156897
137MP0003091_abnormal_cell_migration0.56882089
138MP0004742_abnormal_vestibular_system0.56474414
139MP0005381_digestive/alimentary_phenotyp0.56400262
140MP0006054_spinal_hemorrhage0.56076302
141MP0002075_abnormal_coat/hair_pigmentati0.55217538
142MP0001663_abnormal_digestive_system0.54004549

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)6.99758999
2Septo-optic dysplasia (HP:0100842)5.64825651
3Adactyly (HP:0009776)5.58960934
4Abnormality of the right ventricle (HP:0001707)4.70693568
5Bronchomalacia (HP:0002780)4.39493899
6Megalencephaly (HP:0001355)4.35552016
7Reticulocytopenia (HP:0001896)4.19898633
8Pancreatic fibrosis (HP:0100732)4.15495867
9Abnormal sex determination (HP:0012244)4.06821016
10Sex reversal (HP:0012245)4.06821016
11Abnormality of midbrain morphology (HP:0002418)3.89446414
12Molar tooth sign on MRI (HP:0002419)3.89446414
13Concave nail (HP:0001598)3.85093038
14Maternal diabetes (HP:0009800)3.68155312
15Coronal craniosynostosis (HP:0004440)3.68051174
16Aplasia involving bones of the upper limbs (HP:0009823)3.64873957
17Aplasia of the phalanges of the hand (HP:0009802)3.64873957
18Aplasia involving bones of the extremities (HP:0009825)3.64873957
19Partial duplication of thumb phalanx (HP:0009944)3.62796322
20Aplasia cutis congenita (HP:0001057)3.60438865
2111 pairs of ribs (HP:0000878)3.58071523
22Thickened helices (HP:0000391)3.55248587
23Pancreatic cysts (HP:0001737)3.40210018
24Nephronophthisis (HP:0000090)3.37660783
25Abnormality of the diencephalon (HP:0010662)3.33910992
26Bifid scrotum (HP:0000048)3.27055719
27Aplasia/Hypoplasia of the sternum (HP:0006714)3.26576444
28Rib fusion (HP:0000902)3.22697701
29Partial duplication of the phalanx of hand (HP:0009999)3.14028127
30Oligodactyly (hands) (HP:0001180)3.10371245
31Optic nerve hypoplasia (HP:0000609)3.06686439
32Anal stenosis (HP:0002025)3.06032317
33Abnormality of cells of the erythroid lineage (HP:0012130)3.05499228
34Absent septum pellucidum (HP:0001331)2.98722679
35Alacrima (HP:0000522)2.98552976
36Anomalous pulmonary venous return (HP:0010772)2.97924055
37Sclerocornea (HP:0000647)2.91193661
38Abnormal number of incisors (HP:0011064)2.88569346
39Medial flaring of the eyebrow (HP:0010747)2.86099063
40Porencephaly (HP:0002132)2.85544930
41Skull defect (HP:0001362)2.83912846
42Type II lissencephaly (HP:0007260)2.83587380
43Cystic liver disease (HP:0006706)2.82155700
44Esophageal atresia (HP:0002032)2.78702362
45Abnormality of the renal medulla (HP:0100957)2.76293673
46Abnormality of the 4th metacarpal (HP:0010012)2.75848007
47Down-sloping shoulders (HP:0200021)2.73340701
48Ridged nail (HP:0001807)2.72194529
49Hepatoblastoma (HP:0002884)2.72031971
50Decreased lacrimation (HP:0000633)2.70909120
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69262722
52Morphological abnormality of the inner ear (HP:0011390)2.68465712
53Glossoptosis (HP:0000162)2.68405723
54Broad alveolar ridges (HP:0000187)2.66798564
55Abnormal ciliary motility (HP:0012262)2.66192959
56Abnormal respiratory motile cilium morphology (HP:0005938)2.65699202
57Abnormal respiratory epithelium morphology (HP:0012253)2.65699202
58Exostoses (HP:0100777)2.65311266
59Increased number of teeth (HP:0011069)2.63822497
60Anterior segment dysgenesis (HP:0007700)2.61711258
61Thin ribs (HP:0000883)2.61291917
62Macrocytic anemia (HP:0001972)2.59753453
63Chronic hepatic failure (HP:0100626)2.59088624
64Uterine leiomyosarcoma (HP:0002891)2.56421873
65Leiomyosarcoma (HP:0100243)2.56421873
66Fibular hypoplasia (HP:0003038)2.55676117
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.54073768
68Absent/shortened dynein arms (HP:0200106)2.54073768
69Postaxial foot polydactyly (HP:0001830)2.54070881
70Abnormality of the pulmonary veins (HP:0011718)2.51551196
71Absent hand (HP:0004050)2.49622966
72Growth hormone deficiency (HP:0000824)2.47201136
73Anencephaly (HP:0002323)2.45252411
74Median cleft lip (HP:0000161)2.44133520
75Anophthalmia (HP:0000528)2.42852632
76Tubular atrophy (HP:0000092)2.40602808
77Abnormal number of erythroid precursors (HP:0012131)2.37479164
78Hypoplastic scapulae (HP:0000882)2.36058616
79Aplasia/Hypoplasia of the scapulae (HP:0006713)2.36058616
80Abnormality of the antihelix (HP:0009738)2.35893037
81Facial hemangioma (HP:0000329)2.35792870
82Congenital hepatic fibrosis (HP:0002612)2.33927852
83Broad toe (HP:0001837)2.33048305
84Gait imbalance (HP:0002141)2.32220182
85Pterygium (HP:0001059)2.31893115
86Intestinal atresia (HP:0011100)2.30757921
87Aplasia/Hypoplasia involving the musculature (HP:0001460)2.30613988
88Bicuspid aortic valve (HP:0001647)2.30191066
89Abnormality of the intervertebral disk (HP:0005108)2.29221550
90Trigonocephaly (HP:0000243)2.28885870
91Abnormal respiratory motile cilium physiology (HP:0012261)2.27695458
92Congenital primary aphakia (HP:0007707)2.27515195
93Mixed hearing impairment (HP:0000410)2.27391464
94True hermaphroditism (HP:0010459)2.26345395
95Aplasia/Hypoplasia of the fibula (HP:0006492)2.25929269
96Bifid tongue (HP:0010297)2.24825223
97Aplasia of the musculature (HP:0100854)2.24520868
98Tracheomalacia (HP:0002779)2.22468095
99Holoprosencephaly (HP:0001360)2.22280901
100Nephrogenic diabetes insipidus (HP:0009806)2.20012880
101Abnormality of the middle phalanges of the toes (HP:0010183)2.19030114
102High anterior hairline (HP:0009890)2.18679229
103Missing ribs (HP:0000921)2.18539506
104Broad hallux (HP:0010055)2.18192501
105Postaxial hand polydactyly (HP:0001162)2.17947567
106Polyphagia (HP:0002591)2.17678470
107Vertebral hypoplasia (HP:0008417)2.15227675
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.15227675
109Hypoplasia of the ulna (HP:0003022)2.14485619
110Synostosis of carpal bones (HP:0005048)2.14305896
111Aplasia involving forearm bones (HP:0009822)2.13940037
112Absent forearm bone (HP:0003953)2.13940037
113Abnormality of the labia minora (HP:0012880)2.13693564
114Hip dysplasia (HP:0001385)2.11777279
115Pendular nystagmus (HP:0012043)2.11660500
116Overfolded helix (HP:0000396)2.11550149
117Hypoplastic iliac wings (HP:0002866)2.11132947
118Duplication of thumb phalanx (HP:0009942)2.09222871
119Abnormality of the septum pellucidum (HP:0007375)2.08933594
120Abnormality of the upper arm (HP:0001454)2.07872170
121Transitional cell carcinoma of the bladder (HP:0006740)2.07839811
122Limited elbow extension (HP:0001377)2.07802816
123Colon cancer (HP:0003003)2.07563935
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.07000002
125Aplasia/Hypoplasia of the spleen (HP:0010451)2.05742116
126Plagiocephaly (HP:0001357)2.05681975
127Esophageal varix (HP:0002040)2.04438543
128Preaxial hand polydactyly (HP:0001177)2.02748646
129Cerebellar dysplasia (HP:0007033)2.02594330
130Gastrointestinal atresia (HP:0002589)2.02559284
131Short middle phalanx of the 5th finger (HP:0004220)2.00169705
132Retinal dysplasia (HP:0007973)1.99768882
133Abnormality of the aortic arch (HP:0012303)1.99338759
134Depressed nasal ridge (HP:0000457)1.98801493
135Supernumerary spleens (HP:0009799)1.97698092
136Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.97315069
137Osteoarthritis (HP:0002758)1.97186420
138Infantile muscular hypotonia (HP:0008947)1.96860790
139Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.96698441
140Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96541282
141Hypoplastic pelvis (HP:0008839)1.96537549
142Recurrent corneal erosions (HP:0000495)1.96012162
143Absent radius (HP:0003974)1.95042537
144Asplenia (HP:0001746)1.94219499
145Hallux valgus (HP:0001822)1.94080765
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.93971476
147Abnormal vertebral ossification (HP:0100569)1.93662139
148Hemivertebrae (HP:0002937)1.93372182
149Pallor (HP:0000980)1.92759445
150Pulmonic stenosis (HP:0001642)1.91250952
151Tarsal synostosis (HP:0008368)1.90879182
152Preaxial foot polydactyly (HP:0001841)1.90445344
153Nasolacrimal duct obstruction (HP:0000579)1.89374689
154Occipital encephalocele (HP:0002085)1.88582673
155Abnormally folded helix (HP:0008544)1.87935259
156Midline defect of the nose (HP:0004122)1.87495144
157Abnormality of cochlea (HP:0000375)1.87292577
158Short 4th metacarpal (HP:0010044)1.85284696
159Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85284696
160Absent thumb (HP:0009777)1.84800629
161Lissencephaly (HP:0001339)1.84730024
162Hypoplastic ilia (HP:0000946)1.84474105
163Oligodactyly (HP:0012165)1.84439933
164Calf muscle hypertrophy (HP:0008981)1.84175384
165Wide anterior fontanel (HP:0000260)1.84143347
166Split hand (HP:0001171)1.83535935
167Heterotopia (HP:0002282)1.82003611
168Delayed CNS myelination (HP:0002188)1.80755256
169Poor coordination (HP:0002370)1.80279494
170Meningocele (HP:0002435)1.79742229
171Dandy-Walker malformation (HP:0001305)1.79204189
172Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78785344
173Forearm undergrowth (HP:0009821)1.78704799
174Abnormal drinking behavior (HP:0030082)1.76207194
175Polydipsia (HP:0001959)1.76207194
176Respiratory distress (HP:0002098)1.75517883
177Abnormal rod and cone electroretinograms (HP:0008323)1.74678260
178Iris coloboma (HP:0000612)1.74360944
179Hyperglycinemia (HP:0002154)1.74107535
180Male pseudohermaphroditism (HP:0000037)1.73696097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.15609655
2KSR15.60480590
3SIK34.89080462
4MAPK154.85865104
5PNCK4.70842551
6BUB13.94098662
7EIF2AK13.27599415
8BCR3.16899461
9WNK43.09590405
10WEE12.86086849
11PASK2.71239376
12UHMK12.21482109
13CASK2.20059844
14TYRO32.20045420
15STK392.09361593
16FGFR32.07456506
17CDC72.07119697
18IRAK12.05735371
19FGFR22.04104224
20TLK11.97587015
21ERBB21.85985694
22NTRK21.84566176
23LMTK21.80649685
24MELK1.72664500
25SRPK11.66760116
26CDK191.66057448
27AKT21.55556814
28TESK21.45722793
29DYRK31.45559561
30MINK11.44147495
31TAOK21.42418385
32LRRK21.34242585
33CAMK1G1.33650599
34FGFR11.32024952
35BRD41.31954411
36WNK11.30332835
37ERN11.29856225
38PRKCG1.27722364
39YES11.25965116
40ROCK21.25082008
41BRAF1.23627749
42CDK81.17315650
43MAP3K41.08442645
44TRIB31.08236808
45EPHA41.07882133
46MAP3K121.06191473
47PRPF4B1.05960485
48MAP3K101.05637456
49SIK11.04971292
50PIK3CA1.04312655
51PINK11.01859985
52FGFR41.01398437
53GRK11.00717215
54EPHA31.00515641
55CDK181.00218759
56WNK31.00164432
57PAK40.99134867
58PLK40.95955870
59PDGFRA0.95927223
60TIE10.94730988
61MAP2K70.92998013
62MAP3K110.92592876
63DDR20.91803951
64BRSK10.91473138
65ARAF0.88551962
66PRKCZ0.86732755
67CDK30.84933783
68ROCK10.83895977
69MAP2K40.83453626
70MOS0.81499460
71MAPKAPK50.81052151
72SGK4940.80443346
73SGK2230.80443346
74LIMK10.79313092
75CAMK10.79014217
76CAMKK20.79008909
77PHKG20.77938460
78PHKG10.77938460
79MAP3K70.77868380
80TESK10.77763879
81BMPR1B0.76997824
82PRKCH0.76702752
83ADRBK20.76670454
84STK160.75403871
85MAP2K20.73164242
86CDK150.72954142
87CDK11A0.72658555
88CDK140.72555627
89RPS6KA60.72420441
90NEK10.70345225
91BCKDK0.67651999
92DYRK20.66271980
93NUAK10.62505135
94MKNK20.62455722
95CDC42BPA0.61482938
96TGFBR10.61030366
97NTRK30.60300171
98CSNK1G20.60000901
99GRK60.59429011
100ERBB30.59403561
101NEK60.56509892
102CAMKK10.54331615
103PKN10.54149041
104MARK10.53848390
105PLK20.50742956
106PLK30.50245806
107MARK20.49535167
108PRKCQ0.49055322
109CDK40.48041322
110IRAK20.47473739
111AURKA0.47299440
112AURKB0.45632843
113TSSK60.45487972
114MAP3K90.44378642
115RPS6KC10.43693180
116RPS6KL10.43693180
117BLK0.43658490
118DYRK1B0.43298267
119OXSR10.41636289
120CDK70.41233653
121PRKACA0.40379569
122CDK50.40333291
123MAPK70.39223424
124CAMK2D0.39189426
125TNIK0.39125898
126SGK20.38788457
127MAPK90.38699285
128PIM20.38560930
129DMPK0.38516385
130MAP3K130.38348722
131AKT10.37272027
132CSNK1G10.37142280
133ZAK0.36358938
134MAPK110.36009859
135ICK0.35489695
136DYRK1A0.34088200
137PAK30.33970362
138SRC0.33005477
139NLK0.32685985
140NME10.32675005
141VRK10.32544049
142STK110.32188642
143CSNK1G30.31848290
144RPS6KA20.31178396
145CHEK20.30779753
146ATR0.30493040
147ILK0.30327823
148PRKD30.29792566
149MKNK10.29711117
150PAK60.28138724
151MAPK130.26728931
152CDK120.24356713
153MTOR0.23337617
154CDK90.22381482
155CAMK1D0.22309676
156MAPK100.21948836
157PLK10.21184687
158NEK20.20938099
159RPS6KA10.20647604
160SGK10.20314249
161RPS6KA30.19747952
162FYN0.19598785
163CDK10.18433331
164CHEK10.17745659

Predicted pathways (KEGG)

RankGene SetZ-score
1* Notch signaling pathway_Homo sapiens_hsa043306.21339381
2Ribosome_Homo sapiens_hsa030105.86992940
3Basal cell carcinoma_Homo sapiens_hsa052174.78153796
4Hedgehog signaling pathway_Homo sapiens_hsa043403.44286508
5Dorso-ventral axis formation_Homo sapiens_hsa043203.32233209
6Sulfur relay system_Homo sapiens_hsa041223.26954008
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.99441805
8Axon guidance_Homo sapiens_hsa043602.84737009
9Nitrogen metabolism_Homo sapiens_hsa009102.84160182
10Prion diseases_Homo sapiens_hsa050202.83339449
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.77771563
12Spliceosome_Homo sapiens_hsa030402.45483687
13Oxidative phosphorylation_Homo sapiens_hsa001902.35606399
14Hippo signaling pathway_Homo sapiens_hsa043902.32786350
15Cardiac muscle contraction_Homo sapiens_hsa042602.17919311
16Bladder cancer_Homo sapiens_hsa052192.14261941
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.12913756
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12049989
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09095766
20Parkinsons disease_Homo sapiens_hsa050121.96322793
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92806709
22Melanogenesis_Homo sapiens_hsa049161.92374584
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81274437
24Wnt signaling pathway_Homo sapiens_hsa043101.78864320
25Huntingtons disease_Homo sapiens_hsa050161.71897118
26Cell cycle_Homo sapiens_hsa041101.70397913
27Linoleic acid metabolism_Homo sapiens_hsa005911.62842065
28Fanconi anemia pathway_Homo sapiens_hsa034601.61355371
29MicroRNAs in cancer_Homo sapiens_hsa052061.60846887
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51109903
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39302898
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38346117
33Fatty acid metabolism_Homo sapiens_hsa012121.38329759
34Homologous recombination_Homo sapiens_hsa034401.37132222
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35000425
36Phototransduction_Homo sapiens_hsa047441.31230054
37Fatty acid biosynthesis_Homo sapiens_hsa000611.28706873
38Biosynthesis of amino acids_Homo sapiens_hsa012301.25966645
39Alzheimers disease_Homo sapiens_hsa050101.25295014
40RNA polymerase_Homo sapiens_hsa030201.23631648
41Base excision repair_Homo sapiens_hsa034101.20200762
42TGF-beta signaling pathway_Homo sapiens_hsa043501.19109295
43mRNA surveillance pathway_Homo sapiens_hsa030151.18349129
44Arginine and proline metabolism_Homo sapiens_hsa003301.15375527
45Ether lipid metabolism_Homo sapiens_hsa005651.09066847
46Oocyte meiosis_Homo sapiens_hsa041141.06857684
47Lysine degradation_Homo sapiens_hsa003101.03083071
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.99089225
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97391872
50Fatty acid degradation_Homo sapiens_hsa000710.97004624
51Butanoate metabolism_Homo sapiens_hsa006500.96923204
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.96715181
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96481983
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95999517
55Basal transcription factors_Homo sapiens_hsa030220.93147646
56HTLV-I infection_Homo sapiens_hsa051660.92822998
57Colorectal cancer_Homo sapiens_hsa052100.91233316
58GABAergic synapse_Homo sapiens_hsa047270.90527080
59RNA degradation_Homo sapiens_hsa030180.90168413
60Circadian rhythm_Homo sapiens_hsa047100.88071155
61Olfactory transduction_Homo sapiens_hsa047400.87154553
62Glioma_Homo sapiens_hsa052140.85635995
63Fat digestion and absorption_Homo sapiens_hsa049750.82028774
64Protein export_Homo sapiens_hsa030600.81422269
65DNA replication_Homo sapiens_hsa030300.81251590
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80906728
67Chronic myeloid leukemia_Homo sapiens_hsa052200.80211507
68Peroxisome_Homo sapiens_hsa041460.79828311
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78703400
70Taste transduction_Homo sapiens_hsa047420.77615971
71Pyrimidine metabolism_Homo sapiens_hsa002400.76028995
72Proteoglycans in cancer_Homo sapiens_hsa052050.75453143
73Gap junction_Homo sapiens_hsa045400.74836308
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74720196
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73161748
76Non-small cell lung cancer_Homo sapiens_hsa052230.72005297
77Pathways in cancer_Homo sapiens_hsa052000.71632893
78Arachidonic acid metabolism_Homo sapiens_hsa005900.71026391
79Steroid biosynthesis_Homo sapiens_hsa001000.70988334
80Carbon metabolism_Homo sapiens_hsa012000.70781102
81Glutamatergic synapse_Homo sapiens_hsa047240.68925360
82cAMP signaling pathway_Homo sapiens_hsa040240.67988760
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67336354
84Circadian entrainment_Homo sapiens_hsa047130.64817493
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64764469
86Nucleotide excision repair_Homo sapiens_hsa034200.63782496
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62388410
88Folate biosynthesis_Homo sapiens_hsa007900.62200135
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.60178256
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60110238
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59435231
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58246971
93Nicotine addiction_Homo sapiens_hsa050330.58067968
94Pancreatic cancer_Homo sapiens_hsa052120.57739768
95Cocaine addiction_Homo sapiens_hsa050300.57656217
96Vitamin B6 metabolism_Homo sapiens_hsa007500.56401436
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55189911
98Alcoholism_Homo sapiens_hsa050340.53142659
99Cholinergic synapse_Homo sapiens_hsa047250.51491919
100RNA transport_Homo sapiens_hsa030130.47766417
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47501169
102Hepatitis B_Homo sapiens_hsa051610.47266317
103Metabolic pathways_Homo sapiens_hsa011000.46544826
104Bile secretion_Homo sapiens_hsa049760.46413602
105Propanoate metabolism_Homo sapiens_hsa006400.46177153
106Pyruvate metabolism_Homo sapiens_hsa006200.42223925
107Fatty acid elongation_Homo sapiens_hsa000620.41955991
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.41842510
109Thyroid hormone synthesis_Homo sapiens_hsa049180.41309103
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.40984625
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40500789
112Mismatch repair_Homo sapiens_hsa034300.40358814
113Purine metabolism_Homo sapiens_hsa002300.39747763
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39661020
115Renal cell carcinoma_Homo sapiens_hsa052110.38678488
116Glucagon signaling pathway_Homo sapiens_hsa049220.37334329
117Insulin secretion_Homo sapiens_hsa049110.36547686
118Systemic lupus erythematosus_Homo sapiens_hsa053220.35995498
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35778603
120Morphine addiction_Homo sapiens_hsa050320.35373947
121Oxytocin signaling pathway_Homo sapiens_hsa049210.34958660
122PPAR signaling pathway_Homo sapiens_hsa033200.34608797
123Dopaminergic synapse_Homo sapiens_hsa047280.33794843
124ErbB signaling pathway_Homo sapiens_hsa040120.33386089
125Chemical carcinogenesis_Homo sapiens_hsa052040.33081271
126Ovarian steroidogenesis_Homo sapiens_hsa049130.32816880
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32804782
128Glycerolipid metabolism_Homo sapiens_hsa005610.32802804
129Tyrosine metabolism_Homo sapiens_hsa003500.31980904
130MAPK signaling pathway_Homo sapiens_hsa040100.31370799
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30290553
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30147170
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29997316
134Melanoma_Homo sapiens_hsa052180.29446402
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27558527
136Retinol metabolism_Homo sapiens_hsa008300.27157051
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26060457
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26043580
139Adherens junction_Homo sapiens_hsa045200.25953766
140Small cell lung cancer_Homo sapiens_hsa052220.25513548
141Selenocompound metabolism_Homo sapiens_hsa004500.25030184
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24606790
143Arginine biosynthesis_Homo sapiens_hsa002200.24488091
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23887190
145Estrogen signaling pathway_Homo sapiens_hsa049150.23514441
146N-Glycan biosynthesis_Homo sapiens_hsa005100.22140416
147Epstein-Barr virus infection_Homo sapiens_hsa051690.20671326
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.20156985
149Calcium signaling pathway_Homo sapiens_hsa040200.19856027
150beta-Alanine metabolism_Homo sapiens_hsa004100.18398428
151Tryptophan metabolism_Homo sapiens_hsa003800.17282991

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