HES6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.44435378
2L-phenylalanine metabolic process (GO:0006558)5.44435378
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.42780061
4L-phenylalanine catabolic process (GO:0006559)5.42780061
5behavioral response to nicotine (GO:0035095)5.38675770
6postsynaptic membrane organization (GO:0001941)5.14223047
7neuronal stem cell maintenance (GO:0097150)5.03644391
8aromatic amino acid family catabolic process (GO:0009074)4.79429109
9glyoxylate metabolic process (GO:0046487)4.71250410
10nucleobase catabolic process (GO:0046113)4.41427326
11bile acid biosynthetic process (GO:0006699)4.33653811
12indole-containing compound catabolic process (GO:0042436)4.30953638
13indolalkylamine catabolic process (GO:0046218)4.30953638
14tryptophan catabolic process (GO:0006569)4.30953638
15kynurenine metabolic process (GO:0070189)4.28491343
16DNA deamination (GO:0045006)4.26788058
17alpha-linolenic acid metabolic process (GO:0036109)4.23861323
18central nervous system myelination (GO:0022010)4.19569004
19axon ensheathment in central nervous system (GO:0032291)4.19569004
20tryptophan metabolic process (GO:0006568)4.16410675
21cell migration in hindbrain (GO:0021535)3.98871897
22glycine metabolic process (GO:0006544)3.97340828
23spinal cord association neuron differentiation (GO:0021527)3.92835779
24presynaptic membrane assembly (GO:0097105)3.91208336
25axonal fasciculation (GO:0007413)3.91153591
26paraxial mesoderm development (GO:0048339)3.86909071
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.85074526
28sulfur amino acid catabolic process (GO:0000098)3.83092646
29urea cycle (GO:0000050)3.82275358
30urea metabolic process (GO:0019627)3.82275358
31forebrain neuron differentiation (GO:0021879)3.81243588
32neuron fate determination (GO:0048664)3.77869456
33neuron cell-cell adhesion (GO:0007158)3.72214536
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.70274899
35ethanol oxidation (GO:0006069)3.69289564
36presynaptic membrane organization (GO:0097090)3.68531299
37cysteine metabolic process (GO:0006534)3.67286898
38lysine metabolic process (GO:0006553)3.66132470
39lysine catabolic process (GO:0006554)3.66132470
40negative regulation of fibrinolysis (GO:0051918)3.64789401
41serine family amino acid biosynthetic process (GO:0009070)3.62671302
42neuron recognition (GO:0008038)3.58102986
43substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.55767171
44substrate-independent telencephalic tangential migration (GO:0021826)3.55767171
45nitrogen cycle metabolic process (GO:0071941)3.55660455
46aromatic amino acid family metabolic process (GO:0009072)3.54784697
47pyrimidine nucleobase catabolic process (GO:0006208)3.54641360
48ribosomal small subunit assembly (GO:0000028)3.54470692
49DNA unwinding involved in DNA replication (GO:0006268)3.52560257
50spinal cord development (GO:0021510)3.48079981
51astrocyte differentiation (GO:0048708)3.47523121
52bile acid metabolic process (GO:0008206)3.42581851
53neuron fate specification (GO:0048665)3.40648692
54ganglion development (GO:0061548)3.40359063
55serine family amino acid metabolic process (GO:0009069)3.38989239
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38567160
57translational termination (GO:0006415)3.35731982
58serine family amino acid catabolic process (GO:0009071)3.34852956
59neuron fate commitment (GO:0048663)3.34070415
60high-density lipoprotein particle remodeling (GO:0034375)3.29077856
61auditory behavior (GO:0031223)3.27129136
62mechanosensory behavior (GO:0007638)3.26898090
63regulation of fibrinolysis (GO:0051917)3.26059792
64dermatan sulfate biosynthetic process (GO:0030208)3.26048224
65cranial nerve development (GO:0021545)3.23279552
66cellular ketone body metabolic process (GO:0046950)3.22096235
67dendritic spine morphogenesis (GO:0060997)3.19848498
68complement activation, alternative pathway (GO:0006957)3.19366534
69heart valve formation (GO:0003188)3.19232390
70homocysteine metabolic process (GO:0050667)3.18954402
71enteric nervous system development (GO:0048484)3.18576989
72regulation of protein activation cascade (GO:2000257)3.18240368
73regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.18139014
74establishment of mitochondrion localization (GO:0051654)3.18027514
75negative regulation of cholesterol transport (GO:0032375)3.17982294
76negative regulation of sterol transport (GO:0032372)3.17982294
77indolalkylamine metabolic process (GO:0006586)3.15607498
78imidazole-containing compound metabolic process (GO:0052803)3.15512875
79cerebral cortex radially oriented cell migration (GO:0021799)3.13354066
80positive regulation of Notch signaling pathway (GO:0045747)3.12385765
81coenzyme catabolic process (GO:0009109)3.09904481
82synaptic transmission, cholinergic (GO:0007271)3.09430377
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09318701
84alpha-amino acid catabolic process (GO:1901606)3.08316292
85amino-acid betaine metabolic process (GO:0006577)3.07790617
86tyrosine metabolic process (GO:0006570)3.05735551
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05603525
88positive regulation of neuroblast proliferation (GO:0002052)3.05083452
89positive regulation of oligodendrocyte differentiation (GO:0048714)3.05035505
90microtubule depolymerization (GO:0007019)3.03819514
91peptidyl-glutamic acid carboxylation (GO:0017187)3.03346069
92protein carboxylation (GO:0018214)3.03346069
93negative regulation of oligodendrocyte differentiation (GO:0048715)3.03168647
94pentose-phosphate shunt (GO:0006098)3.02918190
95aldehyde catabolic process (GO:0046185)3.01287927
96cell differentiation in spinal cord (GO:0021515)2.99751725
97cerebral cortex neuron differentiation (GO:0021895)2.98749043
98DNA strand elongation involved in DNA replication (GO:0006271)2.98321013
99pteridine-containing compound biosynthetic process (GO:0042559)2.97827523
100regulation of complement activation (GO:0030449)2.97033857
101phospholipid efflux (GO:0033700)2.96830507
102dermatan sulfate metabolic process (GO:0030205)2.95324711
103tetrahydrofolate metabolic process (GO:0046653)2.94738894
104cellular modified amino acid catabolic process (GO:0042219)2.93959086
105amine catabolic process (GO:0009310)2.93091382
106cellular biogenic amine catabolic process (GO:0042402)2.93091382
107NADPH regeneration (GO:0006740)2.92941283
108regulation of triglyceride catabolic process (GO:0010896)2.92477188
109one-carbon metabolic process (GO:0006730)2.92399671
110arginine metabolic process (GO:0006525)2.92141315
111nonmotile primary cilium assembly (GO:0035058)2.90806209
112photoreceptor cell differentiation (GO:0046530)2.90493397
113eye photoreceptor cell differentiation (GO:0001754)2.90493397
114reverse cholesterol transport (GO:0043691)2.89796673
115regulation of lipoprotein particle clearance (GO:0010984)2.89264117
116L-serine metabolic process (GO:0006563)2.88238696
117regulation of cholesterol esterification (GO:0010872)2.88028201
118folic acid-containing compound biosynthetic process (GO:0009396)2.87761300
119triglyceride homeostasis (GO:0070328)2.87129371
120acylglycerol homeostasis (GO:0055090)2.87129371
121cellular protein complex disassembly (GO:0043624)2.86549428
122benzene-containing compound metabolic process (GO:0042537)2.84938845
123DNA strand elongation (GO:0022616)2.84586069
124dosage compensation (GO:0007549)2.83862756
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83403643
126cellular amino acid catabolic process (GO:0009063)2.81010084
127positive regulation of neural precursor cell proliferation (GO:2000179)2.80232298
128limb development (GO:0060173)2.77535636
129appendage development (GO:0048736)2.77535636
130regulation of synapse structural plasticity (GO:0051823)2.77339608
131response to auditory stimulus (GO:0010996)2.77226371
132protein complex disassembly (GO:0043241)2.76693422
133olfactory bulb development (GO:0021772)2.76564852
134translational elongation (GO:0006414)2.76529593
135disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.76123760
136killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.76123760
137protein-lipid complex remodeling (GO:0034368)2.75275147
138macromolecular complex remodeling (GO:0034367)2.75275147
139plasma lipoprotein particle remodeling (GO:0034369)2.75275147
140retinal ganglion cell axon guidance (GO:0031290)2.74333286
141thalamus development (GO:0021794)2.74221128
142negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73868037
1432-oxoglutarate metabolic process (GO:0006103)2.73155823
144bile acid and bile salt transport (GO:0015721)2.73141193
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.73090139
146mitochondrion transport along microtubule (GO:0047497)2.73075861
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73075861
148neuromuscular synaptic transmission (GO:0007274)2.72939324
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72643213
150central nervous system projection neuron axonogenesis (GO:0021952)2.72621888
151cotranslational protein targeting to membrane (GO:0006613)2.72588620
152ketone body metabolic process (GO:1902224)2.71853741
153transmission of nerve impulse (GO:0019226)2.70721742
154synapse assembly (GO:0007416)2.70631468
155protein localization to synapse (GO:0035418)2.70618974
156pyrimidine nucleobase metabolic process (GO:0006206)2.70250349
157regulation of somitogenesis (GO:0014807)2.69380618
158plasma lipoprotein particle assembly (GO:0034377)2.68457176
159calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68269050
160tricarboxylic acid metabolic process (GO:0072350)2.68229093
161short-chain fatty acid metabolic process (GO:0046459)2.68051539
162viral transcription (GO:0019083)2.67891599
163protein targeting to ER (GO:0045047)2.67740431
164negative regulation of neuron differentiation (GO:0045665)2.66900080
165locomotory exploration behavior (GO:0035641)2.66093507
166epithelial cilium movement (GO:0003351)2.65858933
167cell proliferation in forebrain (GO:0021846)2.65084272
168ethanol metabolic process (GO:0006067)2.64996792
169viral life cycle (GO:0019058)2.64888553
170central nervous system neuron differentiation (GO:0021953)2.64885895
171nucleoside salvage (GO:0043174)2.64703000
172ventricular trabecula myocardium morphogenesis (GO:0003222)2.62540503
173dendrite morphogenesis (GO:0048813)2.61922755
174translesion synthesis (GO:0019985)2.61903648
175macromolecular complex disassembly (GO:0032984)2.61257551
176nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60055818
177epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.59329053
178negative regulation of astrocyte differentiation (GO:0048712)2.58982679
179negative regulation of axonogenesis (GO:0050771)2.58815018
180regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58764270
181NAD biosynthetic process (GO:0009435)2.58305256
182positive regulation of receptor biosynthetic process (GO:0010870)2.57766134
183pyrimidine-containing compound salvage (GO:0008655)2.57551492
184pyrimidine nucleoside salvage (GO:0043097)2.57551492
185layer formation in cerebral cortex (GO:0021819)2.57162613
186complement activation, classical pathway (GO:0006958)2.55940794
187negative regulation of axon extension (GO:0030517)2.55493562
188killing of cells of other organism (GO:0031640)2.55301388
189disruption of cells of other organism (GO:0044364)2.55301388
190renal system development (GO:0072001)2.55072856
191establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54585977
192adult walking behavior (GO:0007628)2.53396879
193regulation of oligodendrocyte differentiation (GO:0048713)2.52046400
194cerebellar granule cell differentiation (GO:0021707)2.50179912
195exploration behavior (GO:0035640)2.48825027
196protein localization to endoplasmic reticulum (GO:0070972)2.48362310
197negative regulation of glial cell differentiation (GO:0045686)2.47112399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.79392308
2E2F7_22180533_ChIP-Seq_HELA_Human5.32364658
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.30068421
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.87226845
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60449514
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.56329022
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35533500
8EZH2_27304074_Chip-Seq_ESCs_Mouse3.06715771
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05555962
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.95609286
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.88520564
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83580835
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.78816944
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.77066057
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.65792906
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65671666
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64347305
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.62413963
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56495525
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47882417
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.47663279
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45983715
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40738298
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40250839
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31692994
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30676629
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.29550417
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.28645381
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27161290
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27161290
31REST_21632747_ChIP-Seq_MESCs_Mouse2.22468603
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21955900
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21757243
34* LXR_22158963_ChIP-Seq_LIVER_Mouse2.20808518
35MYC_22102868_ChIP-Seq_BL_Human2.19448928
36XRN2_22483619_ChIP-Seq_HELA_Human2.18817589
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17176085
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11625115
39* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.10460980
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07816437
41GABP_17652178_ChIP-ChIP_JURKAT_Human2.07141883
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00741239
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99748119
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99253301
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95896048
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94615981
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94242895
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.90741824
49CIITA_25753668_ChIP-Seq_RAJI_Human1.90570220
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89565886
51VDR_21846776_ChIP-Seq_THP-1_Human1.88670140
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.85004804
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83600582
54* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.82726159
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.81465867
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78988281
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78892712
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.78579684
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78035509
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75237895
61* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74265084
62RNF2_27304074_Chip-Seq_NSC_Mouse1.73340556
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73135957
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72024915
65* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70521419
66* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70335280
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69028986
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68173083
69GABP_19822575_ChIP-Seq_HepG2_Human1.67253660
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66690181
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.64625846
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63391611
73* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63200639
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61710544
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.60416427
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55856331
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54129045
78FOXP3_21729870_ChIP-Seq_TREG_Human1.53891626
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52986026
80DCP1A_22483619_ChIP-Seq_HELA_Human1.52256158
81* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50170750
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49346093
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47961399
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47327719
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47008141
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43206734
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40164289
88SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39515404
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38101373
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35081577
91VDR_23849224_ChIP-Seq_CD4+_Human1.32232732
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.31400461
93* KDM2B_26808549_Chip-Seq_K562_Human1.30542977
94* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29485288
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29448507
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29267462
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28775950
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28692771
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.28074237
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25952976
101CTCF_27219007_Chip-Seq_Bcells_Human1.24247032
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.24177922
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.22884544
104AR_21909140_ChIP-Seq_LNCAP_Human1.22205447
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22076282
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22076282
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21970509
108* LXR_22292898_ChIP-Seq_THP-1_Human1.21745967
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20265810
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.18853947
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.17718871
112TTF2_22483619_ChIP-Seq_HELA_Human1.17552371
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17040329
114POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16549354
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16517794
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16458539
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16193466
118ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15996480
119DROSHA_22980978_ChIP-Seq_HELA_Human1.15630333
120* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15432475
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14787352
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12550285
123RARB_27405468_Chip-Seq_BRAIN_Mouse1.12310521
124* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11758226
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09480449
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08803221
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06544926
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05118505
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04893477
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03574861
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02202808
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00437138
133KDM5A_27292631_Chip-Seq_BREAST_Human0.99979825
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99931588
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99834422
136TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99700555
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99660829
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99117322
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98998787
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98890451
141* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.98616828
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.97762072
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97562452
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97201921
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97199788
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96980508
147* CLOCK_20551151_ChIP-Seq_293T_Human0.96745074
148* FOXP1_21924763_ChIP-Seq_HESCs_Human0.96197371
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95657052
150RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94704434
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94462741
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93946351
153EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93785951
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93655476
155CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93353245
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93285841
157CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92763327
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92639348
159BCL6_27268052_Chip-Seq_Bcells_Human0.92592345
160CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92173592
161UTX_26944678_Chip-Seq_JUKART_Human0.91706978
162KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91014378
163* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90980925
164* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90278663
165NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90221802
166DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90155281
167ISL1_27105846_Chip-Seq_CPCs_Mouse0.89680961
168* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85782220
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83752239
170IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82771490
171WDR5_24793694_ChIP-Seq_LNCAP_Human0.81813036
172SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.81454387
173CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81302645
174POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80031314
175THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79988198
176* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79742894
177IGF1R_20145208_ChIP-Seq_DFB_Human0.77108263
178KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.75698245
179AR_21572438_ChIP-Seq_LNCaP_Human0.75328284
180PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74833887
181STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73860947
182SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71637513
183GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68724917
184CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68400908
185FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.67783583
186IRF1_19129219_ChIP-ChIP_H3396_Human0.67116665
187* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66876283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.55679186
2MP0005360_urolithiasis5.73298625
3MP0005365_abnormal_bile_salt4.59352239
4MP0005085_abnormal_gallbladder_physiolo4.15458110
5MP0008875_abnormal_xenobiotic_pharmacok3.00511706
6MP0000778_abnormal_nervous_system2.98995277
7MP0003806_abnormal_nucleotide_metabolis2.95193708
8MP0005423_abnormal_somatic_nervous2.93282399
9MP0002822_catalepsy2.86306040
10MP0003880_abnormal_central_pattern2.85873557
11MP0003136_yellow_coat_color2.73742876
12MP0003787_abnormal_imprinting2.54920071
13MP0008789_abnormal_olfactory_epithelium2.54711979
14MP0003252_abnormal_bile_duct2.51645400
15MP0005220_abnormal_exocrine_pancreas2.40622689
16MP0006276_abnormal_autonomic_nervous2.36875109
17MP0010329_abnormal_lipoprotein_level2.35988933
18MP0010030_abnormal_orbit_morphology2.33825201
19MP0001529_abnormal_vocalization2.30732951
20MP0004859_abnormal_synaptic_plasticity2.29004579
21MP0000566_synostosis2.26180138
22MP0009840_abnormal_foam_cell2.23244360
23MP0001666_abnormal_nutrient_absorption2.10536600
24MP0004270_analgesia2.07805844
25MP0003122_maternal_imprinting2.04903318
26MP0003123_paternal_imprinting2.04531980
27MP0005083_abnormal_biliary_tract2.02182949
28MP0000955_abnormal_spinal_cord1.93377263
29MP0003693_abnormal_embryo_hatching1.90600911
30MP0005171_absent_coat_pigmentation1.89175530
31MP0004885_abnormal_endolymph1.86723487
32MP0003121_genomic_imprinting1.85136012
33MP0002653_abnormal_ependyma_morphology1.84830168
34MP0002638_abnormal_pupillary_reflex1.83241116
35MP0003635_abnormal_synaptic_transmissio1.71437061
36MP0005332_abnormal_amino_acid1.69727847
37MP0002138_abnormal_hepatobiliary_system1.69325436
38MP0003890_abnormal_embryonic-extraembry1.66161703
39MP0002734_abnormal_mechanical_nocicepti1.57501062
40MP0002557_abnormal_social/conspecific_i1.56410086
41MP0003283_abnormal_digestive_organ1.55266213
42MP0002163_abnormal_gland_morphology1.53944675
43MP0005394_taste/olfaction_phenotype1.52626006
44MP0005499_abnormal_olfactory_system1.52626006
45MP0000609_abnormal_liver_physiology1.51961270
46MP0000026_abnormal_inner_ear1.46642904
47MP0004142_abnormal_muscle_tone1.46523361
48MP0003861_abnormal_nervous_system1.46226306
49MP0002882_abnormal_neuron_morphology1.46125071
50MP0004147_increased_porphyrin_level1.43863566
51MP0002272_abnormal_nervous_system1.43682807
52MP0002063_abnormal_learning/memory/cond1.43551917
53MP0002064_seizures1.40764585
54MP0005319_abnormal_enzyme/_coenzyme1.39286901
55MP0001486_abnormal_startle_reflex1.38846087
56MP0002152_abnormal_brain_morphology1.38780200
57MP0009379_abnormal_foot_pigmentation1.37259536
58MP0002184_abnormal_innervation1.37148249
59MP0005645_abnormal_hypothalamus_physiol1.35888068
60MP0003011_delayed_dark_adaptation1.35762318
61MP0001485_abnormal_pinna_reflex1.33286530
62MP0006072_abnormal_retinal_apoptosis1.33228943
63MP0001764_abnormal_homeostasis1.32954191
64MP0002752_abnormal_somatic_nervous1.29773677
65MP0003938_abnormal_ear_development1.28532372
66MP0004811_abnormal_neuron_physiology1.26399797
67MP0002572_abnormal_emotion/affect_behav1.25435011
68MP0009745_abnormal_behavioral_response1.24936924
69MP0000685_abnormal_immune_system1.24556200
70MP0008007_abnormal_cellular_replicative1.23234639
71MP0009643_abnormal_urine_homeostasis1.23207044
72MP0009697_abnormal_copulation1.22943204
73MP0002735_abnormal_chemical_nociception1.22887603
74MP0003868_abnormal_feces_composition1.22115537
75MP0003195_calcinosis1.19972797
76MP0003186_abnormal_redox_activity1.19584213
77MP0001188_hyperpigmentation1.19399937
78MP0010094_abnormal_chromosome_stability1.19002650
79MP0002067_abnormal_sensory_capabilities1.18956154
80MP0001502_abnormal_circadian_rhythm1.17430593
81MP0006054_spinal_hemorrhage1.16150085
82MP0000049_abnormal_middle_ear1.14040800
83MP0002733_abnormal_thermal_nociception1.12106506
84MP0002736_abnormal_nociception_after1.11811282
85MP0004742_abnormal_vestibular_system1.11510101
86MP0003077_abnormal_cell_cycle1.10761995
87MP0001944_abnormal_pancreas_morphology1.10457480
88MP0005253_abnormal_eye_physiology1.10260718
89MP0001984_abnormal_olfaction1.09423883
90MP0000598_abnormal_liver_morphology1.08944672
91MP0000490_abnormal_crypts_of1.07879205
92MP0009053_abnormal_anal_canal1.07315498
93MP0001905_abnormal_dopamine_level1.05866240
94MP0001970_abnormal_pain_threshold1.04416796
95MP0004957_abnormal_blastocyst_morpholog1.01881465
96MP0003763_abnormal_thymus_physiology1.01709980
97MP0002909_abnormal_adrenal_gland1.01483776
98MP0005379_endocrine/exocrine_gland_phen1.01390880
99MP0001968_abnormal_touch/_nociception0.97880299
100MP0002751_abnormal_autonomic_nervous0.97867320
101MP0005195_abnormal_posterior_eye0.97818354
102MP0005167_abnormal_blood-brain_barrier0.97800802
103MP0004133_heterotaxia0.97781064
104MP0002118_abnormal_lipid_homeostasis0.97208102
105MP0004019_abnormal_vitamin_homeostasis0.96780838
106MP0002233_abnormal_nose_morphology0.95857261
107MP0002095_abnormal_skin_pigmentation0.95456366
108MP0003183_abnormal_peptide_metabolism0.94263273
109MP0001963_abnormal_hearing_physiology0.93953875
110MP0004924_abnormal_behavior0.93526414
111MP0005386_behavior/neurological_phenoty0.93526414
112MP0005636_abnormal_mineral_homeostasis0.92032184
113MP0008058_abnormal_DNA_repair0.91146715
114MP0005584_abnormal_enzyme/coenzyme_acti0.90771463
115MP0002081_perinatal_lethality0.88275601
116MP0003634_abnormal_glial_cell0.88033590
117MP0004858_abnormal_nervous_system0.87556529
118MP0002116_abnormal_craniofacial_bone0.87020443
119MP0000537_abnormal_urethra_morphology0.86892926
120MP0001873_stomach_inflammation0.86867589
121MP0002249_abnormal_larynx_morphology0.86270566
122MP0002066_abnormal_motor_capabilities/c0.85054847
123MP0001849_ear_inflammation0.84801995
124MP0006036_abnormal_mitochondrial_physio0.83842882
125MP0005551_abnormal_eye_electrophysiolog0.83334391
126MP0001270_distended_abdomen0.83201970
127MP0002069_abnormal_eating/drinking_beha0.82463745
128MP0005391_vision/eye_phenotype0.81197428
129MP0008961_abnormal_basal_metabolism0.80669122
130MP0000534_abnormal_ureter_morphology0.80643499
131MP0002092_abnormal_eye_morphology0.80344785
132MP0003942_abnormal_urinary_system0.80179617
133MP0001293_anophthalmia0.80096135
134MP0005409_darkened_coat_color0.79284520
135MP0003111_abnormal_nucleus_morphology0.78728716
136MP0001730_embryonic_growth_arrest0.78230934
137MP0006292_abnormal_olfactory_placode0.77983085
138MP0001663_abnormal_digestive_system0.77611048
139MP0002697_abnormal_eye_size0.77250016
140MP0002938_white_spotting0.75654536
141MP0005647_abnormal_sex_gland0.73773419
142MP0002932_abnormal_joint_morphology0.73731675
143MP0001346_abnormal_lacrimal_gland0.73555009
144MP0002234_abnormal_pharynx_morphology0.73014775
145MP0002132_abnormal_respiratory_system0.70641031
146MP0003937_abnormal_limbs/digits/tail_de0.70348698
147MP0009642_abnormal_blood_homeostasis0.69885025
148MP0002019_abnormal_tumor_incidence0.69434868
149MP0005075_abnormal_melanosome_morpholog0.69133539
150MP0003755_abnormal_palate_morphology0.68945680
151MP0000477_abnormal_intestine_morphology0.68283656
152MP0003385_abnormal_body_wall0.67756360
153MP0008469_abnormal_protein_level0.67429977
154MP0000538_abnormal_urinary_bladder0.67209010
155MP0003191_abnormal_cellular_cholesterol0.65899865
156MP0001835_abnormal_antigen_presentation0.65865045
157MP0001853_heart_inflammation0.65182550
158MP0005084_abnormal_gallbladder_morpholo0.64182504
159MP0002089_abnormal_postnatal_growth/wei0.63373992
160MP0009672_abnormal_birth_weight0.63295442
161MP0005646_abnormal_pituitary_gland0.62556159
162MP0003119_abnormal_digestive_system0.62024567
163MP0002396_abnormal_hematopoietic_system0.60980565
164MP0000678_abnormal_parathyroid_gland0.60231186
165MP0000350_abnormal_cell_proliferation0.60032213
166MP0000371_diluted_coat_color0.59422562
167MP0000313_abnormal_cell_death0.59389761
168MP0001286_abnormal_eye_development0.58987311
169MP0000631_abnormal_neuroendocrine_gland0.58193030
170MP0010155_abnormal_intestine_physiology0.58125092
171MP0002098_abnormal_vibrissa_morphology0.57666977
172MP0004808_abnormal_hematopoietic_stem0.57494738
173MP0003115_abnormal_respiratory_system0.56146534
174MP0005381_digestive/alimentary_phenotyp0.55603017
175MP0005408_hypopigmentation0.55174601
176MP0002078_abnormal_glucose_homeostasis0.54843402
177MP0009763_increased_sensitivity_to0.53494379
178MP0000703_abnormal_thymus_morphology0.53461616

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.35322992
2Deep venous thrombosis (HP:0002625)5.08166910
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.05497073
4Rib fusion (HP:0000902)5.03525723
5Anomalous pulmonary venous return (HP:0010772)4.89792006
6Hypobetalipoproteinemia (HP:0003563)4.87365086
7Intrahepatic cholestasis (HP:0001406)4.68515763
8Abnormality of the pulmonary veins (HP:0011718)4.16678925
9Prolonged partial thromboplastin time (HP:0003645)4.07241920
10Oligodactyly (hands) (HP:0001180)4.04342026
11Xanthomatosis (HP:0000991)3.99380947
12Ketosis (HP:0001946)3.90335673
13Hyperammonemia (HP:0001987)3.64974364
14Late onset (HP:0003584)3.63895699
15Abnormality of pyrimidine metabolism (HP:0004353)3.56651820
16Myokymia (HP:0002411)3.52495485
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51617238
18Oligodactyly (HP:0012165)3.42415264
19Hyperlipoproteinemia (HP:0010980)3.35339681
20Ketoacidosis (HP:0001993)3.26259132
21Hypoglycemic coma (HP:0001325)3.22912811
22Esophageal atresia (HP:0002032)3.19334703
23Conjugated hyperbilirubinemia (HP:0002908)3.18678913
24Hyperglycinemia (HP:0002154)3.14230227
25Complement deficiency (HP:0004431)3.09542670
26Microretrognathia (HP:0000308)3.04377293
27Septo-optic dysplasia (HP:0100842)3.03874137
28Joint hemorrhage (HP:0005261)3.01123400
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98835808
30Abnormality of fatty-acid metabolism (HP:0004359)2.96322800
31Hyperbilirubinemia (HP:0002904)2.94757879
32Hepatoblastoma (HP:0002884)2.93302067
33Delayed CNS myelination (HP:0002188)2.92083462
34Hypolipoproteinemia (HP:0010981)2.92007269
35Hemivertebrae (HP:0002937)2.88006964
36Supernumerary spleens (HP:0009799)2.87502630
37Abnormality of the intervertebral disk (HP:0005108)2.81379663
38Hyperglycinuria (HP:0003108)2.77490721
39Abnormality of the intrinsic pathway (HP:0010989)2.71856577
40Morphological abnormality of the inner ear (HP:0011390)2.71191278
41Abnormality of serine family amino acid metabolism (HP:0010894)2.68192275
42Abnormality of glycine metabolism (HP:0010895)2.68192275
43Anophthalmia (HP:0000528)2.65182281
44Abnormality of nucleobase metabolism (HP:0010932)2.63598771
45Spastic diplegia (HP:0001264)2.63176390
46Intestinal atresia (HP:0011100)2.61109052
47Fat malabsorption (HP:0002630)2.59864276
48Abnormality of complement system (HP:0005339)2.58708572
49Megalencephaly (HP:0001355)2.58378911
50Oral leukoplakia (HP:0002745)2.57652895
51Cerebral palsy (HP:0100021)2.57517329
52Abnormality of the 4th metacarpal (HP:0010012)2.56792076
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52900411
54Diastasis recti (HP:0001540)2.51684060
55Abnormality of the diencephalon (HP:0010662)2.51125201
56Focal motor seizures (HP:0011153)2.50435390
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.48490661
58Meningocele (HP:0002435)2.42871536
59Abnormality of cells of the erythroid lineage (HP:0012130)2.39694051
60Abnormality of the aortic arch (HP:0012303)2.37781166
61Generalized aminoaciduria (HP:0002909)2.36860838
62Gastrointestinal atresia (HP:0002589)2.34272355
63Hypercholesterolemia (HP:0003124)2.33700741
64Abnormality of the common coagulation pathway (HP:0010990)2.33678589
65Metabolic acidosis (HP:0001942)2.32601583
66Ragged-red muscle fibers (HP:0003200)2.32375530
67Abnormal number of erythroid precursors (HP:0012131)2.29692181
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28719635
69Dicarboxylic aciduria (HP:0003215)2.28719635
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.28368041
71Gout (HP:0001997)2.27461280
72Brushfield spots (HP:0001088)2.25658860
73Hepatocellular carcinoma (HP:0001402)2.24287137
74Nephronophthisis (HP:0000090)2.23271901
75Abnormality of serum amino acid levels (HP:0003112)2.23200095
76Amblyopia (HP:0000646)2.23022652
77Neonatal onset (HP:0003623)2.20117202
78Opisthotonus (HP:0002179)2.20103493
79Abnormality of cochlea (HP:0000375)2.19356152
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18544430
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18544430
82Abnormality of the anterior horn cell (HP:0006802)2.18167371
83Degeneration of anterior horn cells (HP:0002398)2.18167371
84Gait imbalance (HP:0002141)2.18073962
85Abnormality of the labia minora (HP:0012880)2.17974827
86Abnormality of purine metabolism (HP:0004352)2.17072246
87Cortical dysplasia (HP:0002539)2.16894541
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16379468
89Split foot (HP:0001839)2.16206650
90True hermaphroditism (HP:0010459)2.15342236
91Reduced antithrombin III activity (HP:0001976)2.14394090
92Epidermoid cyst (HP:0200040)2.14136319
93Reticulocytopenia (HP:0001896)2.13749970
94Double outlet right ventricle (HP:0001719)2.11985319
95Congenital malformation of the right heart (HP:0011723)2.11985319
96Cutaneous finger syndactyly (HP:0010554)2.10567551
97Asplenia (HP:0001746)2.09418253
98Retinal dysplasia (HP:0007973)2.08392400
99Hypoglycemic seizures (HP:0002173)2.08169327
100Absent septum pellucidum (HP:0001331)2.05753980
101Rhinitis (HP:0012384)2.05475043
102Abnormality of methionine metabolism (HP:0010901)2.03796030
103Partial duplication of thumb phalanx (HP:0009944)2.03642924
104Cutaneous syndactyly (HP:0012725)2.01908234
105Type II lissencephaly (HP:0007260)2.01726300
106Growth hormone deficiency (HP:0000824)2.00031267
107High anterior hairline (HP:0009890)1.99678173
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99290561
109Aplasia/Hypoplasia of the spleen (HP:0010451)1.97828015
110Fibular hypoplasia (HP:0003038)1.96850310
111Lethargy (HP:0001254)1.96230892
112Elevated hepatic transaminases (HP:0002910)1.93579410
113Abnormality of placental membranes (HP:0011409)1.93454326
114Amniotic constriction ring (HP:0009775)1.93454326
115Optic nerve hypoplasia (HP:0000609)1.92203794
116Abnormality of midbrain morphology (HP:0002418)1.91949359
117Molar tooth sign on MRI (HP:0002419)1.91949359
118Abnormal respiratory epithelium morphology (HP:0012253)1.91046814
119Abnormal respiratory motile cilium morphology (HP:0005938)1.91046814
120Peripheral hypomyelination (HP:0007182)1.88357993
121Hepatic necrosis (HP:0002605)1.87693021
122Abnormal respiratory motile cilium physiology (HP:0012261)1.87526536
123Hypoalphalipoproteinemia (HP:0003233)1.87277392
124Muscle fiber atrophy (HP:0100295)1.86524369
125Type 2 muscle fiber atrophy (HP:0003554)1.85989843
126Abnormality of endocrine pancreas physiology (HP:0012093)1.85210986
127Abnormality of the pancreatic islet cells (HP:0006476)1.85210986
128Spina bifida occulta (HP:0003298)1.84850593
129Mitral stenosis (HP:0001718)1.84182433
130Anencephaly (HP:0002323)1.84058352
131Back pain (HP:0003418)1.83221311
132Insomnia (HP:0100785)1.83122934
133Neoplasm of the adrenal gland (HP:0100631)1.82504611
134Truncus arteriosus (HP:0001660)1.82182894
135Large eyes (HP:0001090)1.80550614
136Cerebellar dysplasia (HP:0007033)1.80443387
137Synostosis of carpal bones (HP:0005048)1.78935555
138Supernumerary ribs (HP:0005815)1.78932423
139Patellar aplasia (HP:0006443)1.78329432
140Holoprosencephaly (HP:0001360)1.78283697
141Partial duplication of the phalanx of hand (HP:0009999)1.77653322
142Congenital primary aphakia (HP:0007707)1.76646480
143Focal seizures (HP:0007359)1.76343811
144Cystic liver disease (HP:0006706)1.76204857
145Pendular nystagmus (HP:0012043)1.74352638
146Aplastic anemia (HP:0001915)1.74260314
147Palpitations (HP:0001962)1.73285537
148Optic nerve coloboma (HP:0000588)1.73036479
149Deep palmar crease (HP:0006191)1.72661092
150Maternal diabetes (HP:0009800)1.72182697
151Cerebral edema (HP:0002181)1.72147660
152Elfin facies (HP:0004428)1.71928986
153Hypoplasia of the thymus (HP:0000778)1.71318240
154Neoplasm of the adrenal cortex (HP:0100641)1.71184038
155Increased muscle lipid content (HP:0009058)1.70819270
156Short 4th metacarpal (HP:0010044)1.70729429
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70729429
158Pancreatic fibrosis (HP:0100732)1.70159313
159Irritability (HP:0000737)1.69359087
160Hyperthyroidism (HP:0000836)1.68928186
161Steatorrhea (HP:0002570)1.68149414
162Hyperacusis (HP:0010780)1.67766676
163Limb dystonia (HP:0002451)1.67590768
164Abnormal ciliary motility (HP:0012262)1.67362743
165Medial flaring of the eyebrow (HP:0010747)1.66772638
166Anterior segment dysgenesis (HP:0007700)1.66504214
167Colon cancer (HP:0003003)1.66301891
168Vertebral fusion (HP:0002948)1.66114635
169Renal hypoplasia (HP:0000089)1.66067057
170Sclerocornea (HP:0000647)1.65795563
171Enlarged kidneys (HP:0000105)1.65182626
17211 pairs of ribs (HP:0000878)1.64355184
173Drooling (HP:0002307)1.64271075
174Pachygyria (HP:0001302)1.64170310
175Nephrogenic diabetes insipidus (HP:0009806)1.63990634
176Abnormality of reticulocytes (HP:0004312)1.63795561
177Abnormal number of incisors (HP:0011064)1.63411125
178Poor coordination (HP:0002370)1.62737889
179Hypoplasia of the brainstem (HP:0002365)1.61767144
180Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61767144
181Down-sloping shoulders (HP:0200021)1.60754181
182Chin dimple (HP:0010751)1.60482082
183Abnormally folded helix (HP:0008544)1.60473891
184Esophageal varix (HP:0002040)1.58300723
185Insulin resistance (HP:0000855)1.56862421
186Death in childhood (HP:0003819)1.55980003
187Recurrent gram-negative bacterial infections (HP:0005420)1.54584077
188Vomiting (HP:0002013)1.52939464
189Prominent metopic ridge (HP:0005487)1.52606036
190Multiple enchondromatosis (HP:0005701)1.52436115
191Increased purine levels (HP:0004368)1.51696298
192Hyperuricemia (HP:0002149)1.51696298
193Abnormal cartilage morphology (HP:0002763)1.51424987
194Epiphyseal stippling (HP:0010655)1.50747187
195Malignant hyperthermia (HP:0002047)1.50060014
196Abnormality of urine glucose concentration (HP:0011016)1.50007369
197Glycosuria (HP:0003076)1.50007369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.29978310
2MARK14.01948387
3BCKDK3.19359167
4CASK3.19353237
5NTRK22.83036090
6DYRK32.72086676
7BUB12.66706545
8STK162.60194466
9MAP2K72.52784057
10TRIB32.50104851
11TLK12.45602483
12DYRK1B2.44001543
13ERN12.41497360
14FGFR42.34972425
15TYRO32.31950381
16MAP3K42.21365075
17CDC72.20941841
18PKN22.16858822
19PRKD32.09276603
20EEF2K2.08500558
21PASK2.01980047
22MAPK111.91145435
23SIK11.91004966
24PNCK1.84168389
25ACVR1B1.83282689
26RPS6KA41.76827629
27MAPK151.73791314
28EPHA41.71927486
29MAPK131.68067421
30SIK31.61414333
31NTRK31.59794764
32FLT31.56721714
33BRSK11.52012702
34NTRK11.47489591
35CDK81.45283994
36NEK21.43810451
37PKN11.40124743
38MAP2K41.39269850
39TGFBR11.37645197
40DYRK21.37195360
41MAP4K21.33207956
42MAP4K11.30724986
43EPHB21.28885745
44SRPK11.28701368
45NME11.28032890
46BTK1.27920725
47UHMK11.25104159
48CDK31.19042187
49CCNB11.17849030
50PRKCG1.16589649
51MAPKAPK31.15703397
52VRK11.14054975
53TESK21.13595340
54AURKA1.12685149
55PAK41.11149698
56TBK11.10862274
57AURKB1.10222226
58SGK4941.10167495
59SGK2231.10167495
60ICK1.10000851
61RPS6KB21.09459893
62ERBB31.09445397
63LRRK21.08559427
64KSR11.04021835
65CDK71.02644230
66CSNK1G21.02382425
67KDR1.01627045
68MARK21.00503413
69PBK0.98971193
70MINK10.96572332
71CSNK1G30.96468829
72DYRK1A0.93353571
73GRK60.92698462
74ERBB20.92236037
75PTK60.91484801
76SCYL20.86149537
77CDK40.85502109
78ATR0.84070264
79TYK20.83979144
80PIM20.81485664
81CDK11A0.81339093
82MAP2K20.80877140
83TESK10.80801667
84PRKCZ0.80243368
85PHKG20.79730008
86PHKG10.79730008
87WNK30.79321346
88CDK50.77661575
89NME20.76534199
90CSF1R0.76006839
91LMTK20.75703209
92BCR0.75689178
93MELK0.75102603
94EIF2AK10.74986928
95ILK0.74404289
96ADRBK20.73544347
97IRAK40.73170519
98HIPK20.72518756
99SGK20.69301463
100INSRR0.69285440
101CDK190.68728081
102VRK20.68476330
103CDK150.68280638
104CDK140.67862268
105CAMK2B0.67390392
106MAP2K60.66343203
107PIK3CG0.66271924
108CSNK1A1L0.66034205
109LIMK10.64470411
110CHEK20.64056158
111PINK10.63523428
112ERBB40.63428201
113CSNK1G10.62873323
114SIK20.62765225
115CDK180.62361876
116AKT20.61205539
117NEK10.57858047
118CAMK40.55578323
119CHUK0.55412557
120ZAP700.55190212
121PLK10.54003570
122WEE10.53910733
123NEK90.52678984
124STK110.52316847
125IKBKE0.51593493
126CAMK1D0.51474306
127CDK60.50630121
128AKT10.50568021
129MAP3K110.50416545
130GRK10.50066184
131SGK10.50018761
132KIT0.49779839
133WNK40.49089220
134YES10.46557514
135RPS6KA10.46129819
136CAMKK10.45975088
137ROCK20.45371147
138MAP3K50.45330214
139MUSK0.44720165
140BLK0.44358858
141NEK60.44113679
142CAMK2G0.44033130
143EIF2AK30.43187128
144MAP3K70.43130606
145PAK60.43060278
146TAOK20.42706463
147MAPKAPK50.42376285
148CSNK1E0.42302594
149MAPK40.42281361
150BRAF0.41697240
151FGFR30.41565341
152CAMK2A0.40997306
153PLK20.40883546
154MAPK70.40851476
155PRKDC0.40453886
156MAP3K80.40427617
157BRD40.39176089
158MAPKAPK20.37985267
159MKNK10.36638112
160FGFR20.34241854
161SYK0.32300722
162ITK0.31135232
163DAPK10.29506769
164* CSNK2A10.29390421
165RPS6KA20.28973395
166LYN0.28638973

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.89544721
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88199449
3DNA replication_Homo sapiens_hsa030302.57563123
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45146100
5Nicotine addiction_Homo sapiens_hsa050332.43043433
6Tryptophan metabolism_Homo sapiens_hsa003802.41161923
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.38362447
8Parkinsons disease_Homo sapiens_hsa050122.23413166
9Fatty acid degradation_Homo sapiens_hsa000712.17984695
10Cardiac muscle contraction_Homo sapiens_hsa042602.17846842
11Oxidative phosphorylation_Homo sapiens_hsa001902.14214596
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13979312
13Axon guidance_Homo sapiens_hsa043602.12671375
14Sulfur relay system_Homo sapiens_hsa041222.11667164
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11392158
16Selenocompound metabolism_Homo sapiens_hsa004502.10697700
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.06652712
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04379350
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00375884
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.99375345
21Folate biosynthesis_Homo sapiens_hsa007901.91815930
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90303676
23Peroxisome_Homo sapiens_hsa041461.87017704
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76983906
25One carbon pool by folate_Homo sapiens_hsa006701.72862699
26Arginine biosynthesis_Homo sapiens_hsa002201.72782332
27Complement and coagulation cascades_Homo sapiens_hsa046101.70795501
28Base excision repair_Homo sapiens_hsa034101.70586999
29Butanoate metabolism_Homo sapiens_hsa006501.68331610
30Ribosome_Homo sapiens_hsa030101.67370646
31Cocaine addiction_Homo sapiens_hsa050301.67212916
32GABAergic synapse_Homo sapiens_hsa047271.66265097
33Huntingtons disease_Homo sapiens_hsa050161.65923365
34Mismatch repair_Homo sapiens_hsa034301.62334777
35Cholinergic synapse_Homo sapiens_hsa047251.54320255
36Propanoate metabolism_Homo sapiens_hsa006401.53554008
37Spliceosome_Homo sapiens_hsa030401.52651721
38Glutamatergic synapse_Homo sapiens_hsa047241.51526974
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46754215
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41292167
41Biosynthesis of amino acids_Homo sapiens_hsa012301.40778537
42Circadian entrainment_Homo sapiens_hsa047131.39367663
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38682588
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38554080
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37624430
46Alzheimers disease_Homo sapiens_hsa050101.37538872
47Proteasome_Homo sapiens_hsa030501.37174795
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36835438
49Histidine metabolism_Homo sapiens_hsa003401.33647518
50Morphine addiction_Homo sapiens_hsa050321.31899830
51Pyruvate metabolism_Homo sapiens_hsa006201.31570326
52Carbon metabolism_Homo sapiens_hsa012001.31043578
53beta-Alanine metabolism_Homo sapiens_hsa004101.30269723
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.29077954
55Chemical carcinogenesis_Homo sapiens_hsa052041.29040847
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27600324
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.26776644
58Dopaminergic synapse_Homo sapiens_hsa047281.26749247
59Synaptic vesicle cycle_Homo sapiens_hsa047211.24819944
60Hedgehog signaling pathway_Homo sapiens_hsa043401.24706609
61Hippo signaling pathway_Homo sapiens_hsa043901.23813208
62Caffeine metabolism_Homo sapiens_hsa002321.22550256
63Pyrimidine metabolism_Homo sapiens_hsa002401.21649848
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.21516154
65Nitrogen metabolism_Homo sapiens_hsa009101.20498225
66Fatty acid metabolism_Homo sapiens_hsa012121.20377869
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20369440
68Systemic lupus erythematosus_Homo sapiens_hsa053221.17758068
69Retinol metabolism_Homo sapiens_hsa008301.17584363
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16466521
71Phenylalanine metabolism_Homo sapiens_hsa003601.14222060
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13264440
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07690942
74Notch signaling pathway_Homo sapiens_hsa043301.07296230
75Sulfur metabolism_Homo sapiens_hsa009201.04996226
76Insulin secretion_Homo sapiens_hsa049111.03433077
77Cell cycle_Homo sapiens_hsa041101.02679317
78Tyrosine metabolism_Homo sapiens_hsa003501.01322073
79Taste transduction_Homo sapiens_hsa047421.01222916
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00747461
81Wnt signaling pathway_Homo sapiens_hsa043101.00221298
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99633019
83Melanogenesis_Homo sapiens_hsa049160.98186437
84Lysine degradation_Homo sapiens_hsa003100.97973519
85Nucleotide excision repair_Homo sapiens_hsa034200.96420876
86Gap junction_Homo sapiens_hsa045400.95810086
87Pentose phosphate pathway_Homo sapiens_hsa000300.94548207
88PPAR signaling pathway_Homo sapiens_hsa033200.92812395
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92788209
90Starch and sucrose metabolism_Homo sapiens_hsa005000.89828236
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85622868
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84821023
93Long-term depression_Homo sapiens_hsa047300.84260749
94Colorectal cancer_Homo sapiens_hsa052100.83659577
95Phototransduction_Homo sapiens_hsa047440.82982289
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82405823
97Basal transcription factors_Homo sapiens_hsa030220.82308887
98Arginine and proline metabolism_Homo sapiens_hsa003300.82227229
99ErbB signaling pathway_Homo sapiens_hsa040120.80712000
100Fat digestion and absorption_Homo sapiens_hsa049750.79471550
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79162013
102Endometrial cancer_Homo sapiens_hsa052130.78370495
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76272070
104Homologous recombination_Homo sapiens_hsa034400.75637037
105Glutathione metabolism_Homo sapiens_hsa004800.73700844
106Staphylococcus aureus infection_Homo sapiens_hsa051500.73127698
107cAMP signaling pathway_Homo sapiens_hsa040240.72402550
108Bile secretion_Homo sapiens_hsa049760.71705788
109Olfactory transduction_Homo sapiens_hsa047400.70349148
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70110345
111ABC transporters_Homo sapiens_hsa020100.67277976
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66651629
113N-Glycan biosynthesis_Homo sapiens_hsa005100.65807786
114Collecting duct acid secretion_Homo sapiens_hsa049660.64883699
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64333960
116Serotonergic synapse_Homo sapiens_hsa047260.63277207
117Bladder cancer_Homo sapiens_hsa052190.59779006
118Gastric acid secretion_Homo sapiens_hsa049710.58945763
119Vitamin B6 metabolism_Homo sapiens_hsa007500.57600086
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56958526
121Fatty acid elongation_Homo sapiens_hsa000620.56656517
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55826775
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52759512
124Amphetamine addiction_Homo sapiens_hsa050310.52248515
125AMPK signaling pathway_Homo sapiens_hsa041520.52102217
126Non-homologous end-joining_Homo sapiens_hsa034500.52091698
127Metabolic pathways_Homo sapiens_hsa011000.51467114
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51187380
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49969331
130p53 signaling pathway_Homo sapiens_hsa041150.49708335
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48513221
132RNA transport_Homo sapiens_hsa030130.47981955
133Oxytocin signaling pathway_Homo sapiens_hsa049210.47394538
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47300536
135MicroRNAs in cancer_Homo sapiens_hsa052060.43818498
136Choline metabolism in cancer_Homo sapiens_hsa052310.43331072
137Protein export_Homo sapiens_hsa030600.42933332
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.42723788
139Glioma_Homo sapiens_hsa052140.42042046
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41166670
141Type II diabetes mellitus_Homo sapiens_hsa049300.40683513
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40021156
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39568751
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37339572
145Galactose metabolism_Homo sapiens_hsa000520.33340698
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33195655
147Primary immunodeficiency_Homo sapiens_hsa053400.32850632
148RNA polymerase_Homo sapiens_hsa030200.31336027
149Vitamin digestion and absorption_Homo sapiens_hsa049770.31034440
150Prion diseases_Homo sapiens_hsa050200.29423158
151RNA degradation_Homo sapiens_hsa030180.27541809
152Viral carcinogenesis_Homo sapiens_hsa052030.24315037
153Purine metabolism_Homo sapiens_hsa002300.23996050
154Steroid biosynthesis_Homo sapiens_hsa001000.23362816
155Chronic myeloid leukemia_Homo sapiens_hsa052200.23168523
156Alcoholism_Homo sapiens_hsa050340.23153651
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23064028
158Basal cell carcinoma_Homo sapiens_hsa052170.21867746
159mRNA surveillance pathway_Homo sapiens_hsa030150.21566955
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20202797
161Fructose and mannose metabolism_Homo sapiens_hsa000510.18271956
162Fanconi anemia pathway_Homo sapiens_hsa034600.17594535
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17020959
164Herpes simplex infection_Homo sapiens_hsa051680.16761278

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