HEXIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)5.78343758
2negative regulation of cell aging (GO:0090344)5.74213306
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.35882552
4GDP-mannose metabolic process (GO:0019673)5.23121485
5regulation of cytokine production involved in inflammatory response (GO:1900015)5.15537016
6adenosine receptor signaling pathway (GO:0001973)5.13876636
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.68339726
8mitotic cell cycle arrest (GO:0071850)4.56983694
9cellular response to ATP (GO:0071318)4.51633445
10mannose metabolic process (GO:0006013)4.44114108
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.38607105
12protein localization to endosome (GO:0036010)4.30745463
13endocytic recycling (GO:0032456)4.14056969
14granulocyte differentiation (GO:0030851)4.09350063
15atrioventricular valve morphogenesis (GO:0003181)4.09295004
16semaphorin-plexin signaling pathway (GO:0071526)4.04647609
17positive regulation of odontogenesis (GO:0042482)4.03497365
18regulation of synapse structural plasticity (GO:0051823)3.99514970
19negative regulation of interleukin-8 production (GO:0032717)3.94636420
20basement membrane organization (GO:0071711)3.86385589
21cellular response to virus (GO:0098586)3.85152870
22negative regulation of erythrocyte differentiation (GO:0045647)3.81112783
23DNA strand renaturation (GO:0000733)3.64162890
24oligosaccharide catabolic process (GO:0009313)3.58675569
25transepithelial transport (GO:0070633)3.53260529
26G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.45586107
27positive regulation of heat generation (GO:0031652)3.45407471
28L-phenylalanine catabolic process (GO:0006559)3.42842037
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42842037
30L-phenylalanine metabolic process (GO:0006558)3.42806321
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42806321
32central nervous system myelination (GO:0022010)3.39348294
33axon ensheathment in central nervous system (GO:0032291)3.39348294
34regulation of cholesterol homeostasis (GO:2000188)3.38061347
35modulation by virus of host process (GO:0019054)3.37611479
36lens fiber cell differentiation (GO:0070306)3.36362991
37type B pancreatic cell proliferation (GO:0044342)3.19198193
38focal adhesion assembly (GO:0048041)3.18682464
39cell-substrate adherens junction assembly (GO:0007045)3.18682464
40regulation of phospholipid biosynthetic process (GO:0071071)3.17781368
41modulation by symbiont of host cellular process (GO:0044068)3.15301619
42negative regulation of toll-like receptor signaling pathway (GO:0034122)3.08256075
43purinergic nucleotide receptor signaling pathway (GO:0035590)3.06458523
44cysteine metabolic process (GO:0006534)3.02325075
45positive regulation of histone deacetylation (GO:0031065)3.00484463
46sphingosine metabolic process (GO:0006670)2.98419865
47regulation of interferon-beta biosynthetic process (GO:0045357)2.98407228
48myelin maintenance (GO:0043217)2.96418323
49planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94624420
50lymph vessel development (GO:0001945)2.93426234
51proline biosynthetic process (GO:0006561)2.93171535
52diol metabolic process (GO:0034311)2.90509567
53regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89491101
54peptidyl-tyrosine autophosphorylation (GO:0038083)2.88513480
55cell-substrate junction assembly (GO:0007044)2.87768328
56sphingomyelin metabolic process (GO:0006684)2.87638808
57response to peptidoglycan (GO:0032494)2.80444316
58embryonic process involved in female pregnancy (GO:0060136)2.80136244
59ribosomal small subunit biogenesis (GO:0042274)2.79252824
60glutamate metabolic process (GO:0006536)2.76559108
61endothelial cell chemotaxis (GO:0035767)2.75852919
62negative regulation of fatty acid transport (GO:2000192)2.74265982
63regulation of chromatin binding (GO:0035561)2.74126161
64phosphate ion transmembrane transport (GO:0035435)2.73383091
65regulation of cell aging (GO:0090342)2.73257691
66regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72907544
67negative regulation of homotypic cell-cell adhesion (GO:0034111)2.72522139
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.69199112
69rRNA methylation (GO:0031167)2.68594287
70regulation of p38MAPK cascade (GO:1900744)2.67714452
71purinergic receptor signaling pathway (GO:0035587)2.65093078
72meiotic chromosome segregation (GO:0045132)2.63906030
73negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63690740
74cell migration involved in sprouting angiogenesis (GO:0002042)2.61398759
75response to muramyl dipeptide (GO:0032495)2.61005326
76regulation of water loss via skin (GO:0033561)2.60163560
77dicarboxylic acid biosynthetic process (GO:0043650)2.59427019
78positive regulation of protein kinase C signaling (GO:0090037)2.58787800
79Rho protein signal transduction (GO:0007266)2.57167232
80detection of molecule of bacterial origin (GO:0032490)2.56125447
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56096981
82estrogen biosynthetic process (GO:0006703)2.55934732
83heme transport (GO:0015886)2.55182194
84negative regulation of response to biotic stimulus (GO:0002832)2.54212343
85sulfur amino acid catabolic process (GO:0000098)2.53848594
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52818042
87growth hormone receptor signaling pathway (GO:0060396)2.52367505
88UV protection (GO:0009650)2.51669653
89alpha-linolenic acid metabolic process (GO:0036109)2.51002704
90ensheathment of neurons (GO:0007272)2.50932660
91axon ensheathment (GO:0008366)2.50932660
92regulation of histone H3-K27 methylation (GO:0061085)2.47322143
93histone H2B ubiquitination (GO:0033523)2.47078566
94stress fiber assembly (GO:0043149)2.45801272
95cellular response to growth hormone stimulus (GO:0071378)2.45083176
96negative regulation of Rho protein signal transduction (GO:0035024)2.44654606
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43697447
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43147571
99hemidesmosome assembly (GO:0031581)2.43140831
100positive regulation of fatty acid beta-oxidation (GO:0032000)2.42714578
101actin filament bundle assembly (GO:0051017)2.42429300
102actin filament bundle organization (GO:0061572)2.42429300
103CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41678272
104myelination (GO:0042552)2.41579089
105sensory perception of taste (GO:0050909)2.41140750
106creatine metabolic process (GO:0006600)2.40725016
107protein retention in ER lumen (GO:0006621)2.40050645
108adenine nucleotide transport (GO:0051503)2.39754022
109response to ATP (GO:0033198)2.39503350
110folic acid metabolic process (GO:0046655)2.38956892
111aromatic amino acid family catabolic process (GO:0009074)2.38891617
112positive regulation of p38MAPK cascade (GO:1900745)2.37831276
113short-chain fatty acid metabolic process (GO:0046459)2.35542332
114ovulation from ovarian follicle (GO:0001542)2.35462419
115respiratory tube development (GO:0030323)2.33542597
116vascular endothelial growth factor signaling pathway (GO:0038084)2.33471827
117regulation of fatty acid beta-oxidation (GO:0031998)2.33395587
118modulation by virus of host morphology or physiology (GO:0019048)2.32725478
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32691607
120potassium ion import (GO:0010107)2.31356182
121cytoplasmic mRNA processing body assembly (GO:0033962)2.31184823
122low-density lipoprotein particle clearance (GO:0034383)2.30512482
123protein targeting to Golgi (GO:0000042)2.29888357
124bile acid biosynthetic process (GO:0006699)2.29687902
125cellular modified amino acid catabolic process (GO:0042219)2.29291563
126drug transmembrane transport (GO:0006855)2.28557131
127peptidyl-glutamic acid carboxylation (GO:0017187)2.27476495
128protein carboxylation (GO:0018214)2.27476495
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.27137536
130establishment of skin barrier (GO:0061436)2.27111288
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.26743456
132detection of light stimulus involved in visual perception (GO:0050908)2.26685457
133detection of light stimulus involved in sensory perception (GO:0050962)2.26685457
134blood vessel endothelial cell migration (GO:0043534)2.26403041
135regulation of viral release from host cell (GO:1902186)2.26225942
136aspartate family amino acid catabolic process (GO:0009068)2.26211849
137regulation of ARF GTPase activity (GO:0032312)2.24861627
138regulation of nucleobase-containing compound transport (GO:0032239)2.23912879
139negative regulation of tumor necrosis factor production (GO:0032720)2.23785003
140nucleotide-sugar biosynthetic process (GO:0009226)2.23775774
141plasma lipoprotein particle clearance (GO:0034381)2.23558716
142response to gravity (GO:0009629)2.22738928
143platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22657962
144response to laminar fluid shear stress (GO:0034616)2.22464506
145positive regulation of protein sumoylation (GO:0033235)2.21924554
146establishment of protein localization to Golgi (GO:0072600)2.19177316
147glyoxylate metabolic process (GO:0046487)2.18216766
148triglyceride homeostasis (GO:0070328)2.17474422
149acylglycerol homeostasis (GO:0055090)2.17474422
150cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.16123758
151adhesion of symbiont to host (GO:0044406)2.14807197
152lysine catabolic process (GO:0006554)2.13260075
153lysine metabolic process (GO:0006553)2.13260075
154surfactant homeostasis (GO:0043129)2.11948556
155acetyl-CoA metabolic process (GO:0006084)2.09672370
156regulation of triglyceride biosynthetic process (GO:0010866)2.06877540
157regulation of bile acid biosynthetic process (GO:0070857)2.05271708
158virion attachment to host cell (GO:0019062)2.04301921
159adhesion of symbiont to host cell (GO:0044650)2.04301921
160response to dietary excess (GO:0002021)2.04082615
161iron coordination entity transport (GO:1901678)2.04072667
162adherens junction assembly (GO:0034333)2.03597510
163dicarboxylic acid catabolic process (GO:0043649)2.03258336
164negative regulation of sterol transport (GO:0032372)2.02602071
165negative regulation of cholesterol transport (GO:0032375)2.02602071
166membrane tubulation (GO:0097320)2.02179450
167regulation of fibrinolysis (GO:0051917)2.01582954
168fatty acid beta-oxidation (GO:0006635)1.99609425
169regulation of triglyceride catabolic process (GO:0010896)1.99288655
170serine family amino acid catabolic process (GO:0009071)1.99225581
171sodium-independent organic anion transport (GO:0043252)1.99118954
172regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.99070575
173positive regulation of fatty acid oxidation (GO:0046321)1.98510651
174positive regulation of lipid catabolic process (GO:0050996)1.98312242
175response to mercury ion (GO:0046689)1.98280004
176reverse cholesterol transport (GO:0043691)1.98054562
177anterior/posterior axis specification, embryo (GO:0008595)1.97571419
178high-density lipoprotein particle remodeling (GO:0034375)1.96770912
179Leydig cell differentiation (GO:0033327)1.96062552
180regulation of cholesterol biosynthetic process (GO:0045540)1.96003761
181negative regulation of fibrinolysis (GO:0051918)1.95030504
182fatty acid oxidation (GO:0019395)1.94600285
183negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.94165373
184negative regulation of lipase activity (GO:0060192)1.93877396
185biotin metabolic process (GO:0006768)1.93733648
186complement activation, alternative pathway (GO:0006957)1.93625847
187mating behavior (GO:0007617)1.93327548
188negative regulation of hormone biosynthetic process (GO:0032353)1.93247598
189negative regulation of hormone metabolic process (GO:0032351)1.93247598
190lipid oxidation (GO:0034440)1.92908233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* VDR_21846776_ChIP-Seq_THP-1_Human3.76117638
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.30190912
3* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.08332070
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.74507050
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60667933
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.55796331
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.50312340
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.42343959
9MYC_22102868_ChIP-Seq_BL_Human2.39107025
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36899116
11* CLOCK_20551151_ChIP-Seq_293T_Human2.32372485
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25080900
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.23336108
14P68_20966046_ChIP-Seq_HELA_Human2.18583096
15* VDR_24763502_ChIP-Seq_THP-1_Human2.17954433
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17636759
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17636759
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17636759
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16552113
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11982209
21* MAF_26560356_Chip-Seq_TH2_Human2.06259507
22XRN2_22483619_ChIP-Seq_HELA_Human2.00873708
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.97191501
24* MAF_26560356_Chip-Seq_TH1_Human1.95723057
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89961141
26ZNF263_19887448_ChIP-Seq_K562_Human1.86344732
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.83475464
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79130861
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74291665
30KDM2B_26808549_Chip-Seq_K562_Human1.70624800
31* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67473080
32* UTX_26944678_Chip-Seq_JUKART_Human1.65403068
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.63357067
34ATF3_27146783_Chip-Seq_COLON_Human1.62830618
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62028281
36BCOR_27268052_Chip-Seq_Bcells_Human1.60048848
37* KDM2B_26808549_Chip-Seq_DND41_Human1.56989511
38* TET1_21451524_ChIP-Seq_MESCs_Mouse1.54842225
39E2F1_20622854_ChIP-Seq_HELA_Human1.54404829
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54153735
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53738359
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.52252606
43TP53_22127205_ChIP-Seq_IMR90_Human1.51531689
44* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.49801892
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49433106
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48820073
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48644008
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47732386
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.47719835
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46545271
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.45690013
52SMC4_20622854_ChIP-Seq_HELA_Human1.44154079
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43999750
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42383148
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.40093209
56* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39712022
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39558035
58* RARA_24833708_ChIP-Seq_LIVER_Mouse1.39447209
59* CTCF_21964334_Chip-Seq_Bcells_Human1.38799614
60CTCF_27219007_Chip-Seq_Bcells_Human1.37222850
61* UBF1/2_26484160_Chip-Seq_HMECs_Human1.37059687
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36834914
63RARB_24833708_ChIP-Seq_LIVER_Mouse1.35658609
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35631682
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32711670
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32634755
67BCL6_27268052_Chip-Seq_Bcells_Human1.32147423
68* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31827595
69* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31622306
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.30993830
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30930588
72PHF8_20622854_ChIP-Seq_HELA_Human1.30754526
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30646114
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.30257214
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.29608556
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29597173
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.28806011
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28202173
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27158334
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27134855
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26571671
82AHR_22903824_ChIP-Seq_MCF-7_Human1.26458739
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26426685
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25694858
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25588865
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25032623
87* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24503468
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.23681087
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.23277975
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22715617
91* CREB1_26743006_Chip-Seq_LNCaP_Human1.22567608
92* NCOR1_26117541_ChIP-Seq_K562_Human1.21166560
93* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20867793
94LXR_22292898_ChIP-Seq_THP-1_Human1.20752002
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20636596
96* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20374160
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.20195707
98TCF7_22412390_ChIP-Seq_EML_Mouse1.19872232
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18221377
100* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18206718
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17310266
102* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16293544
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16217528
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16101222
105* GATA1_19941826_ChIP-Seq_K562_Human1.15929965
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15041476
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.14052046
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13930011
109RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12492205
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12492205
111* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11842147
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11681342
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11422545
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11186696
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11163584
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10785915
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10351352
118* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10262898
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.09926341
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09515315
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09285020
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08960566
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08337429
124* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07745136
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07382053
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06592585
127* RARB_27405468_Chip-Seq_BRAIN_Mouse1.05813591
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05726466
129HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05185895
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04866155
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04242093
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03638876
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03626378
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02805612
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02582142
136* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01908049
137PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01614711
138* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01523420
139* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01100393
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00986282
141* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00885682
142SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99949686
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99650934
144SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99404175
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.99135588
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.99135588
147DROSHA_22980978_ChIP-Seq_HELA_Human0.99018811
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.98918075
149SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98660319
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97820170
151* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97646253
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97223179
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93999319
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93914072
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92469995
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91336064
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90278091
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88844575
159* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88440094
160GATA2_19941826_ChIP-Seq_K562_Human0.88038868
161TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85903866
162JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85499260
163RING1B_27294783_Chip-Seq_ESCs_Mouse0.85166480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.54306546
2MP0005360_urolithiasis3.69365825
3MP0002139_abnormal_hepatobiliary_system3.36843338
4MP0005174_abnormal_tail_pigmentation3.32424498
5MP0005409_darkened_coat_color3.23752179
6MP0005423_abnormal_somatic_nervous3.03095810
7MP0002254_reproductive_system_inflammat2.94216958
8MP0005623_abnormal_meninges_morphology2.68290779
9MP0005085_abnormal_gallbladder_physiolo2.61224637
10MP0004185_abnormal_adipocyte_glucose2.59798854
11MP0010234_abnormal_vibrissa_follicle2.57784498
12MP0008961_abnormal_basal_metabolism2.57427429
13MP0005167_abnormal_blood-brain_barrier2.57204369
14MP0005058_abnormal_lysosome_morphology2.47277881
15MP0001986_abnormal_taste_sensitivity2.33948716
16MP0004381_abnormal_hair_follicle2.30246626
17MP0005365_abnormal_bile_salt2.29080958
18MP0008875_abnormal_xenobiotic_pharmacok2.23427996
19MP0003705_abnormal_hypodermis_morpholog2.21130502
20MP0005666_abnormal_adipose_tissue2.12288196
21MP0005375_adipose_tissue_phenotype1.99073701
22MP0000750_abnormal_muscle_regeneration1.97928846
23MP0003300_gastrointestinal_ulcer1.95689041
24MP0004272_abnormal_basement_membrane1.95503773
25MP0003252_abnormal_bile_duct1.84730356
26MP0010329_abnormal_lipoprotein_level1.78378142
27MP0005257_abnormal_intraocular_pressure1.75515808
28MP0003690_abnormal_glial_cell1.75123256
29MP0009840_abnormal_foam_cell1.73597719
30MP0005332_abnormal_amino_acid1.72021131
31MP0000003_abnormal_adipose_tissue1.70908920
32MP0002796_impaired_skin_barrier1.69194958
33MP0002009_preneoplasia1.68944899
34MP0005023_abnormal_wound_healing1.67051248
35MP0000015_abnormal_ear_pigmentation1.65595385
36MP0001756_abnormal_urination1.63442751
37MP0000920_abnormal_myelination1.63037454
38MP0001661_extended_life_span1.57749820
39MP0005670_abnormal_white_adipose1.57428095
40MP0003045_fibrosis1.55568639
41MP0003329_amyloid_beta_deposits1.52631453
42MP0002118_abnormal_lipid_homeostasis1.49765414
43MP0005451_abnormal_body_composition1.49243506
44MP0001879_abnormal_lymphatic_vessel1.47329627
45MP0003303_peritoneal_inflammation1.41881467
46MP0001502_abnormal_circadian_rhythm1.38903952
47MP0000609_abnormal_liver_physiology1.37694596
48MP0010678_abnormal_skin_adnexa1.35456115
49MP0003172_abnormal_lysosome_physiology1.35334043
50MP0009384_cardiac_valve_regurgitation1.33925151
51MP0010368_abnormal_lymphatic_system1.33813299
52MP0003950_abnormal_plasma_membrane1.28539590
53MP0000462_abnormal_digestive_system1.27690897
54MP0004947_skin_inflammation1.25578880
55MP0003436_decreased_susceptibility_to1.24436236
56MP0004130_abnormal_muscle_cell1.23353312
57MP0005083_abnormal_biliary_tract1.22642662
58MP0000858_altered_metastatic_potential1.22510072
59MP0009931_abnormal_skin_appearance1.20733153
60MP0003656_abnormal_erythrocyte_physiolo1.20181999
61MP0001348_abnormal_lacrimal_gland1.20163624
62MP0003453_abnormal_keratinocyte_physiol1.20122579
63* MP0005330_cardiomyopathy1.19784036
64MP0000747_muscle_weakness1.18278081
65MP0009643_abnormal_urine_homeostasis1.17498770
66MP0004019_abnormal_vitamin_homeostasis1.17078905
67MP0000733_abnormal_muscle_development1.15369842
68MP0003878_abnormal_ear_physiology1.14266241
69MP0005377_hearing/vestibular/ear_phenot1.14266241
70MP0003136_yellow_coat_color1.13216157
71MP0001216_abnormal_epidermal_layer1.12892802
72MP0004885_abnormal_endolymph1.11331827
73MP0001666_abnormal_nutrient_absorption1.10394577
74MP0003448_altered_tumor_morphology1.07974524
75MP0002295_abnormal_pulmonary_circulatio1.07921280
76MP0002160_abnormal_reproductive_system1.07900777
77MP0003191_abnormal_cellular_cholesterol1.07184428
78MP0002971_abnormal_brown_adipose1.06164292
79MP0003828_pulmonary_edema1.02869088
80MP0000639_abnormal_adrenal_gland0.96746254
81MP0003091_abnormal_cell_migration0.96739715
82MP0009278_abnormal_bone_marrow0.96085219
83MP0003075_altered_response_to0.95251612
84MP0000604_amyloidosis0.92801674
85MP0004883_abnormal_blood_vessel0.92604901
86MP0000470_abnormal_stomach_morphology0.92557065
87MP0001188_hyperpigmentation0.90657754
88MP0000367_abnormal_coat/_hair0.90287497
89MP0001919_abnormal_reproductive_system0.89711733
90MP0005164_abnormal_response_to0.88717980
91MP0010771_integument_phenotype0.88050294
92MP0002168_other_aberrant_phenotype0.87788581
93MP0003566_abnormal_cell_adhesion0.87684597
94MP0001340_abnormal_eyelid_morphology0.87045763
95MP0002138_abnormal_hepatobiliary_system0.86916857
96MP0002132_abnormal_respiratory_system0.86863286
97MP0005165_increased_susceptibility_to0.86679123
98MP0001958_emphysema0.86113276
99MP0004270_analgesia0.85985549
100MP0005076_abnormal_cell_differentiation0.84697258
101MP0006138_congestive_heart_failure0.84606956
102MP0002136_abnormal_kidney_physiology0.83962946
103MP0001851_eye_inflammation0.83777202
104MP0000013_abnormal_adipose_tissue0.83753200
105MP0004510_myositis0.83223083
106MP0004484_altered_response_of0.83061334
107MP0000767_abnormal_smooth_muscle0.82907548
108MP0002896_abnormal_bone_mineralization0.82331546
109MP0001873_stomach_inflammation0.82281793
110MP0003634_abnormal_glial_cell0.81804139
111MP0000751_myopathy0.81639420
112MP0004264_abnormal_extraembryonic_tissu0.81498040
113MP0002933_joint_inflammation0.80813053
114MP0003633_abnormal_nervous_system0.79140976
115MP0005334_abnormal_fat_pad0.78824512
116MP0002060_abnormal_skin_morphology0.77692744
117MP0008438_abnormal_cutaneous_collagen0.77506808
118MP0001765_abnormal_ion_homeostasis0.76059425
119MP0001849_ear_inflammation0.75795725
120MP0003279_aneurysm0.74707438
121MP0000377_abnormal_hair_follicle0.74033257
122MP0004808_abnormal_hematopoietic_stem0.73574043
123MP0002108_abnormal_muscle_morphology0.72850898
124MP0000685_abnormal_immune_system0.72331739
125MP0001784_abnormal_fluid_regulation0.71693882
126MP0002909_abnormal_adrenal_gland0.71402256
127MP0002998_abnormal_bone_remodeling0.70851750
128MP0001440_abnormal_grooming_behavior0.70666445
129MP0003638_abnormal_response/metabolism_0.70654583
130MP0004858_abnormal_nervous_system0.70645106
131MP0008874_decreased_physiological_sensi0.70582483
132MP0009115_abnormal_fat_cell0.70555685
133MP0000538_abnormal_urinary_bladder0.70437771
134MP0004043_abnormal_pH_regulation0.70322685
135MP0008260_abnormal_autophagy0.70053268
136MP0009333_abnormal_splenocyte_physiolog0.69148184
137MP0003806_abnormal_nucleotide_metabolis0.69131946
138MP0002877_abnormal_melanocyte_morpholog0.67831016
139MP0000383_abnormal_hair_follicle0.67778524
140MP0002822_catalepsy0.67557731
141MP0005584_abnormal_enzyme/coenzyme_acti0.66801432
142* MP0010630_abnormal_cardiac_muscle0.66141219
143MP0000490_abnormal_crypts_of0.65805001
144MP0001191_abnormal_skin_condition0.64365082
145MP0005647_abnormal_sex_gland0.63558307
146MP0000249_abnormal_blood_vessel0.62984661
147MP0002089_abnormal_postnatal_growth/wei0.62883636
148MP0005501_abnormal_skin_physiology0.62700409
149MP0005621_abnormal_cell_physiology0.61951142
150MP0010155_abnormal_intestine_physiology0.59263655
151MP0004197_abnormal_fetal_growth/weight/0.58356361
152MP0000759_abnormal_skeletal_muscle0.58307672
153* MP0004087_abnormal_muscle_fiber0.57187886
154MP0002166_altered_tumor_susceptibility0.57183082
155MP0003111_abnormal_nucleus_morphology0.56306477

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.14355452
2Hemorrhage of the eye (HP:0011885)5.00911601
3Mesangial abnormality (HP:0001966)4.88232964
4Thin bony cortex (HP:0002753)4.53305419
5Joint hemorrhage (HP:0005261)4.37456636
6Dyschromatopsia (HP:0007641)4.29413141
7Rib fusion (HP:0000902)4.24029965
8Prolonged partial thromboplastin time (HP:0003645)4.05834437
9Popliteal pterygium (HP:0009756)4.00295862
10Choroideremia (HP:0001139)3.79067721
11Facial diplegia (HP:0001349)3.73735469
12Deep venous thrombosis (HP:0002625)3.67877638
13Abnormality of the intrinsic pathway (HP:0010989)3.67690230
14Aplasia of the musculature (HP:0100854)3.66231742
15Poikiloderma (HP:0001029)3.58657823
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51026096
17Akinesia (HP:0002304)3.50669680
18Cerebral inclusion bodies (HP:0100314)3.47949892
19Annular pancreas (HP:0001734)3.36044825
20Squamous cell carcinoma (HP:0002860)3.35376090
21Vaginal fistula (HP:0004320)3.33586509
22Intestinal fistula (HP:0100819)3.31974330
23Neurofibrillary tangles (HP:0002185)3.29317199
24Rectal fistula (HP:0100590)3.23162584
25Rectovaginal fistula (HP:0000143)3.23162584
26Xanthomatosis (HP:0000991)3.19301228
27Renal Fanconi syndrome (HP:0001994)3.11437570
28Increased hepatocellular lipid droplets (HP:0006565)3.05861283
29Amniotic constriction ring (HP:0009775)3.00655554
30Abnormality of placental membranes (HP:0011409)3.00655554
31Intrahepatic cholestasis (HP:0001406)3.00364261
32Atrioventricular block (HP:0001678)2.98463531
33Zonular cataract (HP:0010920)2.93864398
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92423143
35Facial hemangioma (HP:0000329)2.90514842
36Peripheral hypomyelination (HP:0007182)2.85853993
37Fetal akinesia sequence (HP:0001989)2.82402725
38Attenuation of retinal blood vessels (HP:0007843)2.81846517
39Lipid accumulation in hepatocytes (HP:0006561)2.74197197
40Hyperlipoproteinemia (HP:0010980)2.66644803
41Joint stiffness (HP:0001387)2.65262019
42Broad metatarsal (HP:0001783)2.64586616
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63478880
44Turricephaly (HP:0000262)2.59843380
45Cerebral aneurysm (HP:0004944)2.59746631
46Disproportionate tall stature (HP:0001519)2.53575216
47Hyporeflexia of lower limbs (HP:0002600)2.50977668
48Increased circulating renin level (HP:0000848)2.49895692
49Myocardial infarction (HP:0001658)2.47605939
50Pseudobulbar signs (HP:0002200)2.47297466
51Abnormality of the Achilles tendon (HP:0005109)2.44067409
52Increased muscle lipid content (HP:0009058)2.43957484
53Easy fatigability (HP:0003388)2.41904748
54Complement deficiency (HP:0004431)2.41009750
55Respiratory difficulties (HP:0002880)2.40468343
56Hyperglycinuria (HP:0003108)2.39951853
57Exertional dyspnea (HP:0002875)2.35391720
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35191769
59Thin ribs (HP:0000883)2.34897754
60Delayed epiphyseal ossification (HP:0002663)2.34759601
61Increased intramyocellular lipid droplets (HP:0012240)2.33762924
62Myopathic facies (HP:0002058)2.33449756
63Bowing of the arm (HP:0006488)2.33411579
64Bowed forearm bones (HP:0003956)2.33411579
65Abnormal albumin level (HP:0012116)2.32988081
66Hypoalbuminemia (HP:0003073)2.32988081
67Metabolic alkalosis (HP:0200114)2.31164546
68Neonatal onset (HP:0003623)2.30082570
69Abnormality of serine family amino acid metabolism (HP:0010894)2.30034653
70Abnormality of glycine metabolism (HP:0010895)2.30034653
71Ulnar bowing (HP:0003031)2.27722700
72Bronchomalacia (HP:0002780)2.27597748
73Abnormality of the costochondral junction (HP:0000919)2.27564416
74Abnormality of polysaccharide metabolism (HP:0011012)2.27288212
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27288212
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27288212
77Increased CSF protein (HP:0002922)2.26686298
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26402447
79Pterygium (HP:0001059)2.25489283
80Flat occiput (HP:0005469)2.25456407
81Esophageal varix (HP:0002040)2.25333178
82Intention tremor (HP:0002080)2.23350018
83Cheilitis (HP:0100825)2.23349404
84Mitral valve prolapse (HP:0001634)2.22720963
85Achilles tendon contracture (HP:0001771)2.22054808
86Resting tremor (HP:0002322)2.20527253
87Hypokalemic alkalosis (HP:0001949)2.20471872
88Onion bulb formation (HP:0003383)2.20449763
89Short chin (HP:0000331)2.20286745
90Cervical subluxation (HP:0003308)2.19571199
91Anteriorly placed anus (HP:0001545)2.17541060
92Ketosis (HP:0001946)2.16079117
93Mucopolysacchariduria (HP:0008155)2.15361154
94Urinary glycosaminoglycan excretion (HP:0003541)2.15361154
95Sensory axonal neuropathy (HP:0003390)2.14979018
96Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13515016
97Hypophosphatemic rickets (HP:0004912)2.13147208
98Back pain (HP:0003418)2.10976486
99Polycythemia (HP:0001901)2.08093349
100Hypoplastic ischia (HP:0003175)2.05735276
101Gout (HP:0001997)2.05325776
102Broad face (HP:0000283)2.04622935
103Focal segmental glomerulosclerosis (HP:0000097)2.04421234
104Distal lower limb muscle weakness (HP:0009053)2.04388328
105Premature graying of hair (HP:0002216)2.04372791
106Widely patent fontanelles and sutures (HP:0004492)2.02689670
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02595761
108Glomerulosclerosis (HP:0000096)2.02493619
109Coronal craniosynostosis (HP:0004440)2.02056086
110Spastic diplegia (HP:0001264)2.01973616
111Decreased central vision (HP:0007663)2.01454221
112Cerebral hemorrhage (HP:0001342)2.01423027
113Ketoacidosis (HP:0001993)2.00867898
114Abnormal urine phosphate concentration (HP:0012599)1.98700227
115Neonatal respiratory distress (HP:0002643)1.98071711
116Muscle fiber splitting (HP:0003555)1.96904697
117Malnutrition (HP:0004395)1.95759449
118Renal salt wasting (HP:0000127)1.95448202
119Esophageal atresia (HP:0002032)1.95303170
120Macroorchidism (HP:0000053)1.94824350
121Difficulty running (HP:0009046)1.94771994
122Abnormality of the ischium (HP:0003174)1.94414069
123Peripheral demyelination (HP:0011096)1.92663758
124Hypochromic microcytic anemia (HP:0004840)1.91993791
125Hyperinsulinemic hypoglycemia (HP:0000825)1.91929311
126Confusion (HP:0001289)1.90904965
127Progressive external ophthalmoplegia (HP:0000590)1.90100950
128Mask-like facies (HP:0000298)1.89122904
129Abnormality of the neuromuscular junction (HP:0003398)1.87817022
130Fatigable weakness (HP:0003473)1.87817022
131Abnormal atrioventricular conduction (HP:0005150)1.86439567
132Enlarged epiphyses (HP:0010580)1.86293882
133Myotonia (HP:0002486)1.84805562
134Hypoplasia of the iris (HP:0007676)1.84598595
135Axonal loss (HP:0003447)1.84411778
136Short hallux (HP:0010109)1.83863685
137Insidious onset (HP:0003587)1.83128146
138Termporal pattern (HP:0011008)1.83128146
139Rapidly progressive (HP:0003678)1.81760454
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81593795
141Aneurysm (HP:0002617)1.81561940
142Visceral angiomatosis (HP:0100761)1.81330609
143Striae distensae (HP:0001065)1.79887613
144Dysostosis multiplex (HP:0000943)1.79690223
145Increased connective tissue (HP:0009025)1.79601379
146Shallow orbits (HP:0000586)1.78814798
147Hyperactive renin-angiotensin system (HP:0000841)1.78764908
148Malignant hyperthermia (HP:0002047)1.78524152
149Increased variability in muscle fiber diameter (HP:0003557)1.78452796
150Basal cell carcinoma (HP:0002671)1.78199407
151Hemiplegia (HP:0002301)1.77829314
152Dysdiadochokinesis (HP:0002075)1.77550908
153Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76055343
154Epidermoid cyst (HP:0200040)1.75752202
155Dislocated radial head (HP:0003083)1.75464173
156Vascular tortuosity (HP:0004948)1.75314148
157Cholelithiasis (HP:0001081)1.75211833
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74370045
159Premature skin wrinkling (HP:0100678)1.74330479
160Capillary hemangiomas (HP:0005306)1.74175041
161Aplasia/Hypoplasia of the hallux (HP:0008362)1.73026431
162Hypoalphalipoproteinemia (HP:0003233)1.72930235
163Buphthalmos (HP:0000557)1.72498299
164Abnormality of renal resorption (HP:0011038)1.70829157
165Hemangiomatosis (HP:0007461)1.70473560
166Arterial tortuosity (HP:0005116)1.69861388
167Obstructive sleep apnea (HP:0002870)1.69739394
168Epistaxis (HP:0000421)1.69411384
169Right ventricular cardiomyopathy (HP:0011663)1.69274711
170Bony spicule pigmentary retinopathy (HP:0007737)1.69225959
171Hyperglycinemia (HP:0002154)1.69025182
172Rickets (HP:0002748)1.68844476
173Abnormality of the fingertips (HP:0001211)1.68473967
174Abnormality of the radial head (HP:0003995)1.68431634
175Clumsiness (HP:0002312)1.68071319
176Abnormality of nail color (HP:0100643)1.67714504
177Impaired platelet aggregation (HP:0003540)1.66908224
178Abnormal platelet function (HP:0011869)1.66908224
179Arnold-Chiari malformation (HP:0002308)1.66734565
180Abnormality of the common coagulation pathway (HP:0010990)1.65775369
181Acanthosis nigricans (HP:0000956)1.65317048
182Hypercortisolism (HP:0001578)1.64817305
183Diplopia (HP:0000651)1.64811464
184Abnormality of binocular vision (HP:0011514)1.64811464
185Heart block (HP:0012722)1.64808879
186Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64055324
187Abnormality of sulfur amino acid metabolism (HP:0004339)1.63654394
188Round ear (HP:0100830)1.63353542
189Hammertoe (HP:0001765)1.60960329
190Abnormality of chloride homeostasis (HP:0011422)1.59875165
191Delayed CNS myelination (HP:0002188)1.59420954
192Postural tremor (HP:0002174)1.59051308
193Dysmetria (HP:0001310)1.58816105
194Dysmetric saccades (HP:0000641)1.57825247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.31901826
2TRIB32.51207323
3EPHB12.49904734
4STK392.43327057
5RIPK12.40411975
6PRPF4B2.20573477
7MAP2K32.07392148
8CAMK1G2.01972029
9FGFR22.01538217
10BLK1.84823362
11ICK1.82390260
12MAP3K31.82274445
13CDK121.81379254
14OXSR11.79041961
15CAMK1D1.76363729
16PNCK1.67194463
17MAP3K91.64882359
18SIK11.64517525
19WNK41.61015115
20LATS11.59905841
21PTK61.53382697
22SIK31.52459958
23SMG11.48676353
24MST41.48010504
25GRK61.47158351
26FGR1.47146245
27DMPK1.46900392
28MET1.46673484
29TGFBR21.43627038
30MAP3K101.40996225
31ERN11.40108551
32PAK21.40034397
33TYRO31.38625326
34NME21.38289635
35MUSK1.37659290
36TAOK31.33492494
37ARAF1.32256443
38PRKD21.30026560
39BMX1.29900154
40PDGFRA1.27600334
41DDR21.27556874
42IRAK21.25185416
43GSK3A1.23428663
44RIPK41.23064521
45WNK11.20133831
46TBK11.19039922
47ZAP701.14525536
48PDGFRB1.14121230
49IRAK31.13035381
50NTRK11.13025879
51PRKD11.11615956
52MAP2K21.11463183
53FGFR41.10715876
54TAOK21.09560109
55PKN21.08880011
56STK101.08764954
57PAK61.07853602
58KSR21.07842279
59LATS21.03630798
60CDK61.03040686
61PTK2B1.02210027
62EEF2K0.99558554
63ALK0.99252652
64HIPK20.97958509
65RET0.97647404
66TESK20.97514825
67MARK20.91374064
68STK110.89663021
69MELK0.88486478
70PRKCH0.88250542
71MAP3K70.86723763
72MAPKAPK30.85865209
73LRRK20.83762833
74PDK20.81742497
75MAP3K10.78737738
76PTK20.78656139
77MTOR0.78136958
78IKBKE0.76711121
79RPS6KA20.76219714
80MAP4K10.75674662
81IKBKB0.75563858
82CSK0.75304467
83TLK10.75032104
84FER0.74757260
85BRD40.74756387
86ROCK20.73916066
87DYRK30.72926255
88PRKAA20.72148817
89CDK40.71989893
90EPHA20.71291610
91PKN10.71010427
92MAP3K140.70947125
93PAK30.69711919
94GRK10.68843495
95RPS6KL10.68405922
96RPS6KC10.68405922
97TIE10.67693670
98RPS6KB20.67199628
99MAP3K20.66022507
100CHUK0.65818201
101MAP3K110.65300381
102STK380.64434934
103CDK90.64108732
104CDC42BPA0.63901315
105EPHA40.63242123
106SIK20.59562821
107UHMK10.59046049
108PAK40.58968075
109ERBB40.58165434
110INSR0.57863056
111PDPK10.56513136
112MARK30.56023416
113RPS6KA60.55179580
114EPHB20.54243863
115TAOK10.53803805
116ITK0.53406528
117PAK10.52878849
118ADRBK10.52053211
119MST1R0.51814954
120STK30.51740046
121IRAK40.49380927
122SGK30.48676643
123NEK20.48260478
124STK160.47961905
125DYRK1B0.47549075
126DAPK20.46190224
127MAPK70.45619578
128TTN0.45506386
129MAP3K130.44776738
130CSNK1D0.44763036
131PRKG20.44630820
132MAPK120.44108076
133ABL10.43978123
134PRKCQ0.43357044
135MAPK100.41899200
136MAPK110.41486004
137FGFR30.41239793
138PHKG20.40890654
139PHKG10.40890654
140DAPK30.39633313
141PRKD30.39072024
142PIM20.38404525
143YES10.38193157
144JAK20.38158799
145CDK50.37767642
146MAP2K10.36543708
147PDK10.36355525

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.03146400
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.73987356
3Nitrogen metabolism_Homo sapiens_hsa009103.71592921
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76947508
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.72824244
6Other glycan degradation_Homo sapiens_hsa005112.47400924
7Arginine biosynthesis_Homo sapiens_hsa002202.16755625
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.07086711
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06839847
10Fructose and mannose metabolism_Homo sapiens_hsa000511.91774419
11Sphingolipid metabolism_Homo sapiens_hsa006001.90004641
12Butanoate metabolism_Homo sapiens_hsa006501.88482014
13Bile secretion_Homo sapiens_hsa049761.85511908
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65990968
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63357402
16Notch signaling pathway_Homo sapiens_hsa043301.59897233
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59345124
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57931127
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57000516
20PPAR signaling pathway_Homo sapiens_hsa033201.55526911
21mTOR signaling pathway_Homo sapiens_hsa041501.45464083
22Sulfur metabolism_Homo sapiens_hsa009201.42201828
23Complement and coagulation cascades_Homo sapiens_hsa046101.39458491
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39167252
25Circadian rhythm_Homo sapiens_hsa047101.38507790
26Tryptophan metabolism_Homo sapiens_hsa003801.37878399
27Acute myeloid leukemia_Homo sapiens_hsa052211.36383669
28Chronic myeloid leukemia_Homo sapiens_hsa052201.35209475
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33397769
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.32794205
31Propanoate metabolism_Homo sapiens_hsa006401.29869778
32Histidine metabolism_Homo sapiens_hsa003401.28796347
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28695534
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25849982
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.22455730
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22231806
37Inositol phosphate metabolism_Homo sapiens_hsa005621.18457796
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17908873
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16756061
40Non-small cell lung cancer_Homo sapiens_hsa052231.16294513
41Fatty acid degradation_Homo sapiens_hsa000711.12534768
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12223032
43Hepatitis C_Homo sapiens_hsa051601.11291034
44Small cell lung cancer_Homo sapiens_hsa052221.10554086
45Endometrial cancer_Homo sapiens_hsa052131.09904640
46Fatty acid metabolism_Homo sapiens_hsa012121.09759448
47Osteoclast differentiation_Homo sapiens_hsa043801.09724912
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09032574
49B cell receptor signaling pathway_Homo sapiens_hsa046621.08327346
50Lysine degradation_Homo sapiens_hsa003101.07850710
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07768748
52Lysosome_Homo sapiens_hsa041421.06704611
53TNF signaling pathway_Homo sapiens_hsa046681.05712495
54ABC transporters_Homo sapiens_hsa020101.02898243
55Dorso-ventral axis formation_Homo sapiens_hsa043201.01670690
56Endocytosis_Homo sapiens_hsa041441.01454625
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99361231
58Glycerolipid metabolism_Homo sapiens_hsa005610.98545545
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97832855
60Renal cell carcinoma_Homo sapiens_hsa052110.97767154
61Apoptosis_Homo sapiens_hsa042100.97554260
62Pancreatic cancer_Homo sapiens_hsa052120.94918220
63Gastric acid secretion_Homo sapiens_hsa049710.94662524
64Estrogen signaling pathway_Homo sapiens_hsa049150.94478897
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94458301
66ECM-receptor interaction_Homo sapiens_hsa045120.94238091
67FoxO signaling pathway_Homo sapiens_hsa040680.93502967
68Fatty acid biosynthesis_Homo sapiens_hsa000610.93494118
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93045173
70Hepatitis B_Homo sapiens_hsa051610.92122346
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89618853
72Influenza A_Homo sapiens_hsa051640.87055989
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86434608
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.86003705
75Focal adhesion_Homo sapiens_hsa045100.85241788
76Toxoplasmosis_Homo sapiens_hsa051450.83978209
77Fatty acid elongation_Homo sapiens_hsa000620.83755957
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83583789
79Renin secretion_Homo sapiens_hsa049240.83324673
80Arginine and proline metabolism_Homo sapiens_hsa003300.83021408
81Insulin resistance_Homo sapiens_hsa049310.82652246
82Thyroid cancer_Homo sapiens_hsa052160.82182905
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81733209
84Protein digestion and absorption_Homo sapiens_hsa049740.80877311
85Prion diseases_Homo sapiens_hsa050200.79750614
86Hematopoietic cell lineage_Homo sapiens_hsa046400.79220805
87Sulfur relay system_Homo sapiens_hsa041220.79042666
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.78089561
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77336439
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.77245912
91Fat digestion and absorption_Homo sapiens_hsa049750.76408453
92Insulin signaling pathway_Homo sapiens_hsa049100.74235278
93T cell receptor signaling pathway_Homo sapiens_hsa046600.73606696
94GnRH signaling pathway_Homo sapiens_hsa049120.73363324
95Axon guidance_Homo sapiens_hsa043600.73027800
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72663124
97Vitamin digestion and absorption_Homo sapiens_hsa049770.72480405
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72419235
99Salivary secretion_Homo sapiens_hsa049700.71954043
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.70899102
101VEGF signaling pathway_Homo sapiens_hsa043700.70633369
102Cocaine addiction_Homo sapiens_hsa050300.70416223
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69751289
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68881828
105beta-Alanine metabolism_Homo sapiens_hsa004100.68373777
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.67243189
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66534265
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.65613595
109Choline metabolism in cancer_Homo sapiens_hsa052310.65603518
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65578453
111Thyroid hormone synthesis_Homo sapiens_hsa049180.65468490
112Malaria_Homo sapiens_hsa051440.64344323
113Measles_Homo sapiens_hsa051620.64174694
114Staphylococcus aureus infection_Homo sapiens_hsa051500.63754171
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63414998
116Prolactin signaling pathway_Homo sapiens_hsa049170.62243505
117Amoebiasis_Homo sapiens_hsa051460.62204845
118Ovarian steroidogenesis_Homo sapiens_hsa049130.62103415
119HTLV-I infection_Homo sapiens_hsa051660.61687485
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61678139
121Long-term depression_Homo sapiens_hsa047300.61270570
122ErbB signaling pathway_Homo sapiens_hsa040120.61088452
123Peroxisome_Homo sapiens_hsa041460.60600218
124Phenylalanine metabolism_Homo sapiens_hsa003600.60201906
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60069934
126Tight junction_Homo sapiens_hsa045300.59898185
127Bladder cancer_Homo sapiens_hsa052190.59003794
128MicroRNAs in cancer_Homo sapiens_hsa052060.58364295
129Hippo signaling pathway_Homo sapiens_hsa043900.58322348
130Prostate cancer_Homo sapiens_hsa052150.57798262
131Pathways in cancer_Homo sapiens_hsa052000.57795692
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57427245
133Leishmaniasis_Homo sapiens_hsa051400.56841131
134Melanogenesis_Homo sapiens_hsa049160.56336196
135Tuberculosis_Homo sapiens_hsa051520.56239261
136Proteoglycans in cancer_Homo sapiens_hsa052050.55767223
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54853619
138Tyrosine metabolism_Homo sapiens_hsa003500.54703619
139Glioma_Homo sapiens_hsa052140.54606049
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54512720
141Rap1 signaling pathway_Homo sapiens_hsa040150.54321315
142Chemical carcinogenesis_Homo sapiens_hsa052040.54208026
143Caffeine metabolism_Homo sapiens_hsa002320.53023248
144Oxytocin signaling pathway_Homo sapiens_hsa049210.52755991
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52312504
146Galactose metabolism_Homo sapiens_hsa000520.52248853
147Type II diabetes mellitus_Homo sapiens_hsa049300.52161454
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.51484113
149Mineral absorption_Homo sapiens_hsa049780.51103379
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.50347286
151Adherens junction_Homo sapiens_hsa045200.50336790
152Herpes simplex infection_Homo sapiens_hsa051680.50229664
153Viral carcinogenesis_Homo sapiens_hsa052030.50135112
154Hedgehog signaling pathway_Homo sapiens_hsa043400.48874390
155MAPK signaling pathway_Homo sapiens_hsa040100.48652495
156AMPK signaling pathway_Homo sapiens_hsa041520.48506976
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48146607
158Chemokine signaling pathway_Homo sapiens_hsa040620.47719542
159Glutathione metabolism_Homo sapiens_hsa004800.47446963
160Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47374229
161Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47282349
162Long-term potentiation_Homo sapiens_hsa047200.47192791
163Leukocyte transendothelial migration_Homo sapiens_hsa046700.47177084
164Glutamatergic synapse_Homo sapiens_hsa047240.47037187
165Starch and sucrose metabolism_Homo sapiens_hsa005000.46992304
166Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46732971
167Glucagon signaling pathway_Homo sapiens_hsa049220.46605931
168Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46479808
169Basal cell carcinoma_Homo sapiens_hsa052170.45933243
170cAMP signaling pathway_Homo sapiens_hsa040240.45655321
171Gap junction_Homo sapiens_hsa045400.45342413
172Platelet activation_Homo sapiens_hsa046110.44753202
173PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44083888

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