HEXIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.72255886
2blood coagulation, intrinsic pathway (GO:0007597)5.18746498
3neutrophil activation involved in immune response (GO:0002283)5.06689497
4cell wall macromolecule metabolic process (GO:0044036)4.99370440
5cell wall macromolecule catabolic process (GO:0016998)4.99370440
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.67698137
7sperm-egg recognition (GO:0035036)4.60975217
8multicellular organism reproduction (GO:0032504)4.54807295
9motile cilium assembly (GO:0044458)4.52850346
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40991434
11L-phenylalanine metabolic process (GO:0006558)4.40991434
12protein neddylation (GO:0045116)4.40478060
13binding of sperm to zona pellucida (GO:0007339)4.39030576
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.37452307
15negative regulation of thymocyte apoptotic process (GO:0070244)4.32504086
16regulation of cilium movement (GO:0003352)4.21101862
17protein maturation by protein folding (GO:0022417)4.16436264
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.11973798
19L-phenylalanine catabolic process (GO:0006559)4.11973798
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.07914780
21fusion of sperm to egg plasma membrane (GO:0007342)4.03052205
22male meiosis (GO:0007140)4.00280403
23DNA methylation involved in gamete generation (GO:0043046)3.99127708
24thrombin receptor signaling pathway (GO:0070493)3.98613680
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.96844632
26low-density lipoprotein particle remodeling (GO:0034374)3.96554579
27axonemal dynein complex assembly (GO:0070286)3.96207304
28cell-cell recognition (GO:0009988)3.95181582
29microtubule depolymerization (GO:0007019)3.94351166
30cilium or flagellum-dependent cell motility (GO:0001539)3.94139281
31epithelial cilium movement (GO:0003351)3.91845736
32leukocyte migration involved in inflammatory response (GO:0002523)3.91442648
33sperm motility (GO:0030317)3.91047015
34polyamine biosynthetic process (GO:0006596)3.89505558
35acrosome reaction (GO:0007340)3.87578754
36autophagic vacuole fusion (GO:0000046)3.86621347
37positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82120407
38protein insertion into membrane (GO:0051205)3.79411662
39deoxyribonucleotide catabolic process (GO:0009264)3.75229602
40lipoxygenase pathway (GO:0019372)3.72165296
41vocalization behavior (GO:0071625)3.71604053
42microtubule severing (GO:0051013)3.71350504
43regulation of cholesterol esterification (GO:0010872)3.58244477
44spermatid development (GO:0007286)3.57458011
45high-density lipoprotein particle remodeling (GO:0034375)3.51673703
46positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.51329447
47pyrimidine nucleotide catabolic process (GO:0006244)3.50442597
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.49649751
49reproduction (GO:0000003)3.45484300
50positive regulation of lipoprotein lipase activity (GO:0051006)3.44536379
51positive regulation of triglyceride lipase activity (GO:0061365)3.44536379
52deoxyribose phosphate catabolic process (GO:0046386)3.44181337
53neuron cell-cell adhesion (GO:0007158)3.43991052
54cilium movement (GO:0003341)3.41413845
55acrosome assembly (GO:0001675)3.40687899
56cullin deneddylation (GO:0010388)3.40632129
57negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.39789278
58chaperone-mediated protein transport (GO:0072321)3.38083272
59protein deneddylation (GO:0000338)3.36947341
60nucleotide salvage (GO:0043173)3.36502716
61positive regulation of systemic arterial blood pressure (GO:0003084)3.34166091
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.31152536
63platelet aggregation (GO:0070527)3.30133294
64purine nucleotide salvage (GO:0032261)3.27216383
65plasma membrane fusion (GO:0045026)3.25863840
66proline biosynthetic process (GO:0006561)3.23790965
67regulation of platelet aggregation (GO:0090330)3.18615997
68negative regulation of meiosis (GO:0045835)3.14420457
69adenosine receptor signaling pathway (GO:0001973)3.11810485
70single fertilization (GO:0007338)3.09042427
71reverse cholesterol transport (GO:0043691)3.07117187
72iron-sulfur cluster assembly (GO:0016226)3.05987878
73metallo-sulfur cluster assembly (GO:0031163)3.05987878
74prostanoid biosynthetic process (GO:0046457)3.05693901
75prostaglandin biosynthetic process (GO:0001516)3.05693901
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.05166453
77G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.04094569
78regulation of skeletal muscle contraction (GO:0014819)3.02949146
79regulation of platelet activation (GO:0010543)3.01030122
80protein localization to cilium (GO:0061512)2.98636153
81tyrosine metabolic process (GO:0006570)2.98269478
82calcium ion-dependent exocytosis (GO:0017156)2.97098843
83polyamine metabolic process (GO:0006595)2.97077768
84poly(A)+ mRNA export from nucleus (GO:0016973)2.96729223
85purine deoxyribonucleotide catabolic process (GO:0009155)2.96569021
86regulation of synaptic vesicle exocytosis (GO:2000300)2.96427795
87adult feeding behavior (GO:0008343)2.94977264
88pyrimidine nucleoside salvage (GO:0043097)2.94329184
89pyrimidine-containing compound salvage (GO:0008655)2.94329184
90urinary tract smooth muscle contraction (GO:0014848)2.93958582
91purine-containing compound salvage (GO:0043101)2.92967093
92platelet degranulation (GO:0002576)2.92865594
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92600721
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91921787
95regulation of mitochondrial translation (GO:0070129)2.91562976
96regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91465549
97synaptonemal complex organization (GO:0070193)2.90026100
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89663130
99regulation of protein kinase A signaling (GO:0010738)2.88353327
100regulation of meiosis I (GO:0060631)2.86877346
101pinocytosis (GO:0006907)2.86823780
102negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.84262209
103negative regulation of norepinephrine secretion (GO:0010700)2.83658936
104protein localization to synapse (GO:0035418)2.82580935
105purinergic nucleotide receptor signaling pathway (GO:0035590)2.82572982
106organelle membrane fusion (GO:0090174)2.80746965
107fatty acid elongation (GO:0030497)2.80618008
108pentose metabolic process (GO:0019321)2.80222375
109meiotic nuclear division (GO:0007126)2.78648523
110base-excision repair, AP site formation (GO:0006285)2.78578061
111neurotransmitter secretion (GO:0007269)2.75986792
112negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.75089989
113angiogenesis involved in wound healing (GO:0060055)2.74350009
114regulation of microtubule-based movement (GO:0060632)2.73153846
115synaptonemal complex assembly (GO:0007130)2.72913917
116regulation of synaptic vesicle transport (GO:1902803)2.72162621
117negative regulation of T cell apoptotic process (GO:0070233)2.71939401
118meiotic cell cycle (GO:0051321)2.71231451
119synaptic vesicle exocytosis (GO:0016079)2.70768577
120negative regulation of B cell apoptotic process (GO:0002903)2.70283023
121negative regulation of DNA-templated transcription, elongation (GO:0032785)2.70212386
122neutrophil activation (GO:0042119)2.68409925
123positive regulation of action potential (GO:0045760)2.67403583
124energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67397874
125ATP hydrolysis coupled proton transport (GO:0015991)2.67397874
126GDP-mannose metabolic process (GO:0019673)2.66891989
127beta-amyloid metabolic process (GO:0050435)2.66809668
128fertilization (GO:0009566)2.66375325
129regulation of mast cell degranulation (GO:0043304)2.66361829
130mitotic sister chromatid segregation (GO:0000070)2.65718224
131negative regulation of homotypic cell-cell adhesion (GO:0034111)2.65192036
132regulation of Golgi to plasma membrane protein transport (GO:0042996)2.64130214
133behavioral response to ethanol (GO:0048149)2.63969796
134regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60816310
135spermatogenesis (GO:0007283)2.60677387
136negative regulation of calcium ion transport into cytosol (GO:0010523)2.60507485
137positive regulation of endothelial cell differentiation (GO:0045603)2.60301889
138male gamete generation (GO:0048232)2.60285219
139protein carboxylation (GO:0018214)2.59195339
140peptidyl-glutamic acid carboxylation (GO:0017187)2.59195339
141negative regulation of lymphocyte apoptotic process (GO:0070229)2.58960892
142mitochondrial calcium ion transport (GO:0006851)2.58691983
143cell recognition (GO:0008037)2.57974918
144mitochondrial fission (GO:0000266)2.56294384
145platelet formation (GO:0030220)2.56150003
146regulation of release of cytochrome c from mitochondria (GO:0090199)2.56004859
147cellular metabolic compound salvage (GO:0043094)2.55298872
148regulation of T-helper 2 cell differentiation (GO:0045628)2.54863862
149striatum development (GO:0021756)2.54770745
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54415166
151gamete generation (GO:0007276)2.53864148
152pentose-phosphate shunt (GO:0006098)2.53513132
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53156937
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53099062
155citrulline biosynthetic process (GO:0019240)2.53018198
156proline metabolic process (GO:0006560)2.52137411
157positive regulation of TOR signaling (GO:0032008)2.52002810
158pigment granule transport (GO:0051904)2.51428133
159transferrin transport (GO:0033572)2.51323957
160positive regulation of cellular amine metabolic process (GO:0033240)2.50640860
161regulation of chromatin binding (GO:0035561)2.50402078
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.50285536
163peptidyl-arginine omega-N-methylation (GO:0035247)2.50076881
164retinal rod cell development (GO:0046548)2.50032239
165mitotic metaphase plate congression (GO:0007080)2.49707844
166intraciliary transport (GO:0042073)2.49665303
167deoxyribose phosphate metabolic process (GO:0019692)2.48522387
168cellular response to virus (GO:0098586)2.48351549
169glucose catabolic process (GO:0006007)2.48218584
170nucleoside salvage (GO:0043174)2.47340890
171establishment of pigment granule localization (GO:0051905)2.47107577
172regulation of synaptic transmission, GABAergic (GO:0032228)2.46732966
173negative regulation of stress fiber assembly (GO:0051497)2.46627841
174extracellular fibril organization (GO:0043206)2.46233842
175regulation of norepinephrine secretion (GO:0014061)2.45780440
176spermatid nucleus differentiation (GO:0007289)2.45445468
177proteasome assembly (GO:0043248)2.42964617
178positive regulation of mitochondrial fission (GO:0090141)2.42858235
179response to histamine (GO:0034776)2.42845691
180regulation of meiosis (GO:0040020)2.41603575
181protein K6-linked ubiquitination (GO:0085020)2.40642628
182positive regulation of uterine smooth muscle contraction (GO:0070474)2.39614919
183protein complex biogenesis (GO:0070271)2.38716359
184positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38486880
185G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38265023
186pigment granule localization (GO:0051875)2.37605391
187aggressive behavior (GO:0002118)2.37308774
188mitochondrial respiratory chain complex assembly (GO:0033108)2.36926121
189positive regulation of synapse assembly (GO:0051965)2.35605547
190regulation of inclusion body assembly (GO:0090083)2.34117925
191regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34038560
192synaptic vesicle docking involved in exocytosis (GO:0016081)2.33475075
193neurotransmitter transport (GO:0006836)2.33177579
194ferric iron transport (GO:0015682)2.33089272
195trivalent inorganic cation transport (GO:0072512)2.33089272
196microtubule polymerization or depolymerization (GO:0031109)2.32111629
197DNA replication initiation (GO:0006270)2.31745359
198negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31744634
199GTP biosynthetic process (GO:0006183)2.31288765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21967905
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.10558483
3E2F7_22180533_ChIP-Seq_HELA_Human2.67308667
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65106312
5* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59915160
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59053437
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55690202
8* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54095228
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38284910
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37306397
11VDR_21846776_ChIP-Seq_THP-1_Human2.33117060
12REST_21632747_ChIP-Seq_MESCs_Mouse2.32284725
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15508799
14GBX2_23144817_ChIP-Seq_PC3_Human2.14429133
15* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13078147
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.12828229
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05956853
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02877947
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01114695
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99097636
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96047436
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95987610
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93575154
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92815691
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92293647
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90511164
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86739681
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86114384
29LXR_22292898_ChIP-Seq_THP-1_Human1.85982480
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85171374
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.84201662
32* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83749483
33TAF15_26573619_Chip-Seq_HEK293_Human1.80999091
34* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80334914
35FUS_26573619_Chip-Seq_HEK293_Human1.79450243
36* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79387816
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78343013
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75533519
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75113013
40IGF1R_20145208_ChIP-Seq_DFB_Human1.74853143
41* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74055448
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.70959348
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70617782
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.70453180
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.69500246
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69435503
47* EST1_17652178_ChIP-ChIP_JURKAT_Human1.68975174
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68923466
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.68846737
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68040937
51P68_20966046_ChIP-Seq_HELA_Human1.66743220
52BCL6_27268052_Chip-Seq_Bcells_Human1.66575225
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66429425
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65937499
55RNF2_27304074_Chip-Seq_NSC_Mouse1.64224515
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61928066
57BCOR_27268052_Chip-Seq_Bcells_Human1.60848163
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.60433105
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60362915
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59568066
61MYC_22102868_ChIP-Seq_BL_Human1.58969015
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58396147
63* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57587964
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56641869
65UTX_26944678_Chip-Seq_JUKART_Human1.56633162
66ZNF263_19887448_ChIP-Seq_K562_Human1.56520349
67SCL_19346495_ChIP-Seq_HPC-7_Human1.55936948
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55693741
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.55620365
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55457452
71* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55044082
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.50959970
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.50229850
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49809727
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.49798151
76* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49017396
77SPI1_23127762_ChIP-Seq_K562_Human1.48864038
78* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47859425
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46883074
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46595519
81* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45358775
82CTCF_21964334_Chip-Seq_Bcells_Human1.41806555
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.41693398
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.41347251
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37439806
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37237633
87SPI1_20517297_ChIP-Seq_HL60_Human1.36568985
88VDR_24763502_ChIP-Seq_THP-1_Human1.35509660
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.35157440
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34904083
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.34308150
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34156991
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33923000
94* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33491963
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33132095
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32107103
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31170806
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30748746
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28992976
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28802507
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28514500
102* NCOR1_26117541_ChIP-Seq_K562_Human1.28497764
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28477209
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28461479
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28222146
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.27825068
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27078962
108* ETS1_20019798_ChIP-Seq_JURKAT_Human1.26884906
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26345503
110DCP1A_22483619_ChIP-Seq_HELA_Human1.25783836
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25634536
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24837165
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24524755
114CTCF_26484167_Chip-Seq_Bcells_Mouse1.24396044
115* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23893322
116SPI1_23547873_ChIP-Seq_NB4_Human1.23705444
117VDR_22108803_ChIP-Seq_LS180_Human1.23391296
118P300_19829295_ChIP-Seq_ESCs_Human1.21368480
119PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20946680
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.20208897
121* CIITA_25753668_ChIP-Seq_RAJI_Human1.20093011
122* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20017832
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19485456
124MAF_26560356_Chip-Seq_TH1_Human1.19312253
125IRF1_19129219_ChIP-ChIP_H3396_Human1.19305457
126* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17656959
127ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16856244
128PHF8_20622854_ChIP-Seq_HELA_Human1.15660523
129EWS_26573619_Chip-Seq_HEK293_Human1.14956515
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14606292
131* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14539730
132P300_27268052_Chip-Seq_Bcells_Human1.14250799
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13703376
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11014678
135GATA1_26923725_Chip-Seq_HPCs_Mouse1.10001412
136* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09918107
137XRN2_22483619_ChIP-Seq_HELA_Human1.09832571
138KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09569309
139FOXP1_21924763_ChIP-Seq_HESCs_Human1.09477789
140* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09009239
141RARA_24833708_ChIP-Seq_LIVER_Mouse1.08847287
142SMAD4_21799915_ChIP-Seq_A2780_Human1.08497587
143MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07732047
144SRF_21415370_ChIP-Seq_HL-1_Mouse1.07534593
145RARB_24833708_ChIP-Seq_LIVER_Mouse1.07510366
146NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07486860
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07379022
148YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07152742
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07106245
150* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07082527
151GATA1_19941826_ChIP-Seq_K562_Human1.06537972
152E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06351322
153ZNF274_21170338_ChIP-Seq_K562_Hela1.06201049
154* MAF_26560356_Chip-Seq_TH2_Human1.06117884
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03466792
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02438248
157GABP_19822575_ChIP-Seq_HepG2_Human1.00341330
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98914044
159MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98670332
160FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97472968
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.95982004
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95628688
163TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94809567
164GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94726579
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94211051
166SOX9_26525672_Chip-Seq_HEART_Mouse0.94132822
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93563407
168SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91850623
169AR_25329375_ChIP-Seq_VCAP_Human0.90891287
170CBP_20019798_ChIP-Seq_JUKART_Human0.90461332
171IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90461332
172POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88349206
173ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87870752
174EZH2_27304074_Chip-Seq_ESCs_Mouse0.87029790
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85760964
176REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84531403
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84292414
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.84256891
179NFE2_27457419_Chip-Seq_LIVER_Mouse0.83880850
180KDM2B_26808549_Chip-Seq_REH_Human0.83435102
181CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82862517
182MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82260853
183SOX2_16153702_ChIP-ChIP_HESCs_Human0.82159546
184* FOXP3_21729870_ChIP-Seq_TREG_Human0.81930570
185VDR_23849224_ChIP-Seq_CD4+_Human0.81919852
186JUN_21703547_ChIP-Seq_K562_Human0.81658967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.76829212
2MP0005410_abnormal_fertilization3.80874468
3MP0005058_abnormal_lysosome_morphology3.77446270
4MP0001529_abnormal_vocalization3.59524732
5MP0008877_abnormal_DNA_methylation3.32492337
6MP0008260_abnormal_autophagy3.10481041
7MP0005451_abnormal_body_composition2.88965071
8MP0002653_abnormal_ependyma_morphology2.83793064
9MP0003880_abnormal_central_pattern2.79592273
10MP0008004_abnormal_stomach_pH2.77219787
11MP0009046_muscle_twitch2.74838258
12MP0005083_abnormal_biliary_tract2.71300272
13MP0003191_abnormal_cellular_cholesterol2.48740106
14MP0001968_abnormal_touch/_nociception2.48062139
15MP0009840_abnormal_foam_cell2.43040674
16MP0004859_abnormal_synaptic_plasticity2.34229323
17MP0006072_abnormal_retinal_apoptosis2.34072996
18MP0003646_muscle_fatigue2.33522254
19MP0002736_abnormal_nociception_after2.30488529
20MP0003635_abnormal_synaptic_transmissio2.30347881
21MP0002132_abnormal_respiratory_system2.28499290
22MP0005423_abnormal_somatic_nervous2.28256494
23MP0006276_abnormal_autonomic_nervous2.19258458
24MP0005646_abnormal_pituitary_gland2.14864952
25MP0001929_abnormal_gametogenesis2.14820329
26MP0005645_abnormal_hypothalamus_physiol2.14800055
27MP0009745_abnormal_behavioral_response2.11566414
28MP0003698_abnormal_male_reproductive2.09958218
29MP0000465_gastrointestinal_hemorrhage2.09791392
30MP0006292_abnormal_olfactory_placode2.04980206
31MP0001986_abnormal_taste_sensitivity2.04516161
32MP0003787_abnormal_imprinting2.04010454
33MP0002735_abnormal_chemical_nociception2.03050733
34MP0002638_abnormal_pupillary_reflex2.02835035
35MP0002064_seizures2.01556463
36MP0002572_abnormal_emotion/affect_behav1.98644228
37MP0010094_abnormal_chromosome_stability1.97488344
38MP0003724_increased_susceptibility_to1.92868879
39MP0003806_abnormal_nucleotide_metabolis1.92376426
40MP0001984_abnormal_olfaction1.91836647
41MP0002332_abnormal_exercise_endurance1.91301683
42MP0002734_abnormal_mechanical_nocicepti1.82227083
43MP0002272_abnormal_nervous_system1.81609705
44MP0005551_abnormal_eye_electrophysiolog1.81252567
45MP0002063_abnormal_learning/memory/cond1.80259784
46MP0002102_abnormal_ear_morphology1.71931850
47MP0000751_myopathy1.69499700
48MP0009278_abnormal_bone_marrow1.64154269
49MP0002210_abnormal_sex_determination1.63970023
50MP0005386_behavior/neurological_phenoty1.63967239
51MP0004924_abnormal_behavior1.63967239
52MP0003693_abnormal_embryo_hatching1.63328064
53MP0003121_genomic_imprinting1.62497274
54MP0001835_abnormal_antigen_presentation1.61711462
55MP0010386_abnormal_urinary_bladder1.61193385
56MP0001188_hyperpigmentation1.60226155
57MP0001545_abnormal_hematopoietic_system1.59911218
58MP0005397_hematopoietic_system_phenotyp1.59911218
59MP0003122_maternal_imprinting1.59028963
60MP0002822_catalepsy1.58580600
61MP0003436_decreased_susceptibility_to1.57016874
62MP0002139_abnormal_hepatobiliary_system1.55718143
63MP0004036_abnormal_muscle_relaxation1.55363573
64MP0004233_abnormal_muscle_weight1.50803953
65MP0000358_abnormal_cell_content/1.50715219
66MP0003111_abnormal_nucleus_morphology1.50529053
67MP0004142_abnormal_muscle_tone1.49943803
68MP0000749_muscle_degeneration1.48936519
69MP0002557_abnormal_social/conspecific_i1.48828692
70MP0002067_abnormal_sensory_capabilities1.47647593
71MP0003123_paternal_imprinting1.45069030
72MP0004510_myositis1.43754494
73MP0008057_abnormal_DNA_replication1.43287650
74MP0003186_abnormal_redox_activity1.42746941
75MP0000343_altered_response_to1.42562875
76MP0002161_abnormal_fertility/fecundity1.41000722
77MP0001502_abnormal_circadian_rhythm1.40990659
78MP0001486_abnormal_startle_reflex1.40755650
79MP0005253_abnormal_eye_physiology1.37611607
80MP0002184_abnormal_innervation1.37267590
81MP0004130_abnormal_muscle_cell1.36334180
82MP0001440_abnormal_grooming_behavior1.34114617
83MP0005360_urolithiasis1.33771798
84MP0000653_abnormal_sex_gland1.32160122
85MP0000747_muscle_weakness1.30116521
86MP0006035_abnormal_mitochondrial_morpho1.26653513
87MP0005394_taste/olfaction_phenotype1.26332287
88MP0005499_abnormal_olfactory_system1.26332287
89MP0008058_abnormal_DNA_repair1.25330298
90MP0008789_abnormal_olfactory_epithelium1.25183850
91MP0010329_abnormal_lipoprotein_level1.23123362
92MP0003718_maternal_effect1.22094544
93MP0001145_abnormal_male_reproductive1.21688347
94MP0001905_abnormal_dopamine_level1.21634276
95MP0003638_abnormal_response/metabolism_1.20762171
96MP0000689_abnormal_spleen_morphology1.20141514
97MP0005365_abnormal_bile_salt1.19987504
98MP0001501_abnormal_sleep_pattern1.19903551
99MP0002163_abnormal_gland_morphology1.19743601
100MP0004270_analgesia1.19266317
101MP0000372_irregular_coat_pigmentation1.17435569
102MP0000858_altered_metastatic_potential1.17178317
103MP0002398_abnormal_bone_marrow1.17131112
104MP0001661_extended_life_span1.16758481
105MP0009697_abnormal_copulation1.16435889
106MP0008875_abnormal_xenobiotic_pharmacok1.15243334
107MP0005167_abnormal_blood-brain_barrier1.14940229
108MP0003303_peritoneal_inflammation1.14474390
109MP0001970_abnormal_pain_threshold1.14206606
110MP0003077_abnormal_cell_cycle1.13825509
111MP0003828_pulmonary_edema1.13617842
112MP0005666_abnormal_adipose_tissue1.12753865
113MP0005584_abnormal_enzyme/coenzyme_acti1.12636087
114MP0000631_abnormal_neuroendocrine_gland1.12299880
115MP0004957_abnormal_blastocyst_morpholog1.11612319
116MP0002106_abnormal_muscle_physiology1.11542776
117MP0002733_abnormal_thermal_nociception1.10673564
118MP0003656_abnormal_erythrocyte_physiolo1.09355787
119MP0008874_decreased_physiological_sensi1.08451832
120MP0002723_abnormal_immune_serum1.07558531
121MP0002160_abnormal_reproductive_system1.06857367
122MP0005025_abnormal_response_to1.06215918
123MP0002882_abnormal_neuron_morphology1.04547567
124MP0004811_abnormal_neuron_physiology1.04473105
125MP0005330_cardiomyopathy1.04258909
126MP0002722_abnormal_immune_system1.03186751
127MP0001764_abnormal_homeostasis1.02564015
128MP0002429_abnormal_blood_cell1.02254252
129MP0003879_abnormal_hair_cell1.02038177
130MP0008569_lethality_at_weaning1.00700050
131MP0009763_increased_sensitivity_to1.00326090
132MP0000955_abnormal_spinal_cord0.99562704
133MP0003566_abnormal_cell_adhesion0.98983271
134MP0001800_abnormal_humoral_immune0.97603958
135MP0002152_abnormal_brain_morphology0.97193404
136MP0009642_abnormal_blood_homeostasis0.97027515
137MP0005000_abnormal_immune_tolerance0.96215023
138MP0002419_abnormal_innate_immunity0.95592340
139MP0002066_abnormal_motor_capabilities/c0.95530566
140MP0000685_abnormal_immune_system0.94430724
141MP0002752_abnormal_somatic_nervous0.94205892
142MP0002148_abnormal_hypersensitivity_rea0.93914038
143MP0002229_neurodegeneration0.92214288
144MP0009333_abnormal_splenocyte_physiolog0.91791928
145MP0008872_abnormal_physiological_respon0.91381024
146MP0002420_abnormal_adaptive_immunity0.91220475
147MP0001819_abnormal_immune_cell0.90680548
148MP0002452_abnormal_antigen_presenting0.90645921
149MP0005375_adipose_tissue_phenotype0.89424817
150MP0005501_abnormal_skin_physiology0.88980153
151MP0008932_abnormal_embryonic_tissue0.88320373
152MP0005670_abnormal_white_adipose0.87844412
153MP0000778_abnormal_nervous_system0.87695051
154MP0002972_abnormal_cardiac_muscle0.87477422
155MP0005389_reproductive_system_phenotype0.87250512
156MP0004087_abnormal_muscle_fiber0.87215398
157MP0000759_abnormal_skeletal_muscle0.86770832
158MP0003329_amyloid_beta_deposits0.86180203
159MP0002118_abnormal_lipid_homeostasis0.85964618
160MP0000230_abnormal_systemic_arterial0.85658934
161MP0000716_abnormal_immune_system0.84941985
162MP0003075_altered_response_to0.84694235
163MP0005266_abnormal_metabolism0.84427758
164MP0004084_abnormal_cardiac_muscle0.84319938
165MP0000003_abnormal_adipose_tissue0.84309637
166MP0003183_abnormal_peptide_metabolism0.84138055
167MP0000490_abnormal_crypts_of0.83195363
168MP0003172_abnormal_lysosome_physiology0.82659085
169MP0002019_abnormal_tumor_incidence0.80885474
170MP0001963_abnormal_hearing_physiology0.79556118
171MP0006138_congestive_heart_failure0.79346452
172MP0000598_abnormal_liver_morphology0.78719959
173MP0003861_abnormal_nervous_system0.77276843
174MP0000015_abnormal_ear_pigmentation0.77073811
175MP0005379_endocrine/exocrine_gland_phen0.76894696
176MP0003699_abnormal_female_reproductive0.76831812
177MP0003890_abnormal_embryonic-extraembry0.76213367
178MP0005384_cellular_phenotype0.75807445
179MP0001119_abnormal_female_reproductive0.74873825
180MP0001533_abnormal_skeleton_physiology0.74763195
181MP0000249_abnormal_blood_vessel0.74339543
182MP0002751_abnormal_autonomic_nervous0.73762659
183MP0003866_abnormal_defecation0.73703482
184MP0001919_abnormal_reproductive_system0.71031338
185MP0000026_abnormal_inner_ear0.70549515
186MP0002277_abnormal_respiratory_mucosa0.69225327
187MP0002837_dystrophic_cardiac_calcinosis0.68696258
188MP0006036_abnormal_mitochondrial_physio0.68169472

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.30141340
2Menorrhagia (HP:0000132)7.25288035
3Purpura (HP:0000979)6.72670268
4Petechiae (HP:0000967)6.29763783
5Increased mean platelet volume (HP:0011877)6.03276876
6Abnormal platelet volume (HP:0011876)5.80528775
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.33397970
8Absent/shortened dynein arms (HP:0200106)5.33397970
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.30662741
10Epistaxis (HP:0000421)5.05864603
11Abnormal respiratory motile cilium physiology (HP:0012261)4.53545106
12Abnormal respiratory motile cilium morphology (HP:0005938)4.49963828
13Abnormal respiratory epithelium morphology (HP:0012253)4.49963828
14Gingival bleeding (HP:0000225)4.28143594
15Rhinitis (HP:0012384)4.06841563
16Abnormal ciliary motility (HP:0012262)3.95805291
17Hyperlipoproteinemia (HP:0010980)3.86886179
18Abnormal hair whorl (HP:0010721)3.78334949
19Nemaline bodies (HP:0003798)3.64899140
20Paralysis (HP:0003470)3.63393585
21Severe visual impairment (HP:0001141)3.63079717
22Exercise-induced myalgia (HP:0003738)3.62267322
23Focal motor seizures (HP:0011153)3.61460614
24Gait imbalance (HP:0002141)3.60172029
25Impaired platelet aggregation (HP:0003540)3.50130737
26Abnormal platelet function (HP:0011869)3.50130737
27Muscle fiber inclusion bodies (HP:0100299)3.49591422
28Congenital primary aphakia (HP:0007707)3.45179624
29Medial flaring of the eyebrow (HP:0010747)3.42894213
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.35569535
31Nephrogenic diabetes insipidus (HP:0009806)3.28466498
32Birth length less than 3rd percentile (HP:0003561)3.28383958
33Ragged-red muscle fibers (HP:0003200)3.26008630
34Hemorrhage of the eye (HP:0011885)3.25822055
35Abnormality of lateral ventricle (HP:0030047)3.25128915
36Febrile seizures (HP:0002373)3.08783732
37Rhabdomyolysis (HP:0003201)3.02754618
38Infertility (HP:0000789)2.96625119
39Increased serum ferritin (HP:0003281)2.96230141
40Hyperventilation (HP:0002883)2.92913449
41Distal lower limb amyotrophy (HP:0008944)2.88421493
42Joint hemorrhage (HP:0005261)2.86325063
43Abnormal pupillary function (HP:0007686)2.85729549
44Atonic seizures (HP:0010819)2.83610818
45Increased intramyocellular lipid droplets (HP:0012240)2.80635375
46Abnormality of the common coagulation pathway (HP:0010990)2.79246215
47Distal lower limb muscle weakness (HP:0009053)2.76508705
48Myopathic facies (HP:0002058)2.75836035
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74858949
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74858949
51Abnormality of the labia minora (HP:0012880)2.73542599
52Chronic bronchitis (HP:0004469)2.72413444
53Progressive muscle weakness (HP:0003323)2.72205263
54Poor coordination (HP:0002370)2.72045441
55Hepatosplenomegaly (HP:0001433)2.71999327
56Absence seizures (HP:0002121)2.71426068
57Increased muscle lipid content (HP:0009058)2.67835571
58Epileptic encephalopathy (HP:0200134)2.65209685
59Microvesicular hepatic steatosis (HP:0001414)2.64735020
60Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62066924
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59597904
62Generalized aminoaciduria (HP:0002909)2.59506606
63Obstructive lung disease (HP:0006536)2.58674011
64Chronic obstructive pulmonary disease (HP:0006510)2.58674011
65Dialeptic seizures (HP:0011146)2.58650620
66Poor suck (HP:0002033)2.57434917
67Upper limb muscle weakness (HP:0003484)2.56542054
68Central scotoma (HP:0000603)2.53653642
69Acute necrotizing encephalopathy (HP:0006965)2.52926730
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50524581
71Abnormality of alanine metabolism (HP:0010916)2.50524581
72Hyperalaninemia (HP:0003348)2.50524581
73Abnormality of iron homeostasis (HP:0011031)2.49214077
74Congenital stationary night blindness (HP:0007642)2.45860842
75Abnormality of macrophages (HP:0004311)2.44584529
76Mitochondrial inheritance (HP:0001427)2.41984995
77Abnormal mitochondria in muscle tissue (HP:0008316)2.41365159
78Renal Fanconi syndrome (HP:0001994)2.40617582
79Hepatic necrosis (HP:0002605)2.38951677
80Visual hallucinations (HP:0002367)2.36388734
81Xanthomatosis (HP:0000991)2.34487645
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34210939
83Polyphagia (HP:0002591)2.33275118
84Breast hypoplasia (HP:0003187)2.32378609
85Nephronophthisis (HP:0000090)2.31791397
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.31181981
87Myoglobinuria (HP:0002913)2.30840872
88Exercise-induced muscle cramps (HP:0003710)2.29153851
89Microretrognathia (HP:0000308)2.27611567
90Acute hepatic failure (HP:0006554)2.26268563
91Agammaglobulinemia (HP:0004432)2.21526713
92Abnormality of glycolysis (HP:0004366)2.20436873
93Increased serum pyruvate (HP:0003542)2.20436873
94Abnormality of macular pigmentation (HP:0008002)2.20072892
95Cholecystitis (HP:0001082)2.19850014
96Abnormal gallbladder physiology (HP:0012438)2.19850014
97Molar tooth sign on MRI (HP:0002419)2.16520842
98Abnormality of midbrain morphology (HP:0002418)2.16520842
99Broad foot (HP:0001769)2.15456444
100Focal seizures (HP:0007359)2.15405196
101Aplasia/Hypoplasia of the lens (HP:0008063)2.14969866
102Abnormality of transition element cation homeostasis (HP:0011030)2.13398542
103Pheochromocytoma (HP:0002666)2.11813856
104Hypoplasia of the fovea (HP:0007750)2.11671923
105Aplasia/Hypoplasia of the fovea (HP:0008060)2.11671923
106Chromsome breakage (HP:0040012)2.10271722
107Pancreatic fibrosis (HP:0100732)2.10250629
108Type 2 muscle fiber atrophy (HP:0003554)2.09368182
109Increased CSF lactate (HP:0002490)2.09180790
110Vaginal atresia (HP:0000148)2.08901388
111Genital tract atresia (HP:0001827)2.08182477
112Exercise intolerance (HP:0003546)2.07424616
113Increased hepatocellular lipid droplets (HP:0006565)2.04730040
114Centrally nucleated skeletal muscle fibers (HP:0003687)2.03821666
115Progressive macrocephaly (HP:0004481)2.03261418
116Deep venous thrombosis (HP:0002625)2.02972520
117Bony spicule pigmentary retinopathy (HP:0007737)2.02500153
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02386749
1193-Methylglutaconic aciduria (HP:0003535)2.02134539
120Scotoma (HP:0000575)2.01601493
121Poikilocytosis (HP:0004447)2.01531720
122Male infertility (HP:0003251)2.01357060
123Acanthocytosis (HP:0001927)2.01096840
124Fatigue (HP:0012378)2.01015224
125Abnormality of the fovea (HP:0000493)1.99456104
126Muscle stiffness (HP:0003552)1.97848892
127Pendular nystagmus (HP:0012043)1.96034657
128Dysostosis multiplex (HP:0000943)1.94292292
129Eczematoid dermatitis (HP:0000976)1.93157886
130Muscle fiber splitting (HP:0003555)1.93137944
131Abnormal rod and cone electroretinograms (HP:0008323)1.92697889
132Progressive inability to walk (HP:0002505)1.91142089
133Impulsivity (HP:0100710)1.89903262
134Progressive cerebellar ataxia (HP:0002073)1.89660911
135Neuroendocrine neoplasm (HP:0100634)1.89645094
136Spontaneous abortion (HP:0005268)1.89133748
137Nausea (HP:0002018)1.88861932
138Rimmed vacuoles (HP:0003805)1.88423539
139Aganglionic megacolon (HP:0002251)1.87625466
140Bruising susceptibility (HP:0000978)1.87408481
141Cellulitis (HP:0100658)1.87023654
142Areflexia of lower limbs (HP:0002522)1.86555494
143Muscle fibrillation (HP:0010546)1.86317676
144Optic disc pallor (HP:0000543)1.86272737
145Inability to walk (HP:0002540)1.85903662
146Acute encephalopathy (HP:0006846)1.85122726
147Unsteady gait (HP:0002317)1.85101413
148Abnormality of the Achilles tendon (HP:0005109)1.84742416
149Hepatocellular necrosis (HP:0001404)1.83188113
150Tongue fasciculations (HP:0001308)1.82521559
151Lower limb amyotrophy (HP:0007210)1.82401660
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82134267
153Astigmatism (HP:0000483)1.81062866
154Specific learning disability (HP:0001328)1.80840834
155Median cleft lip (HP:0000161)1.80036520
156Rough bone trabeculation (HP:0100670)1.78738078
157Abnormality of skeletal muscle fiber size (HP:0012084)1.78272840
158Recurrent abscess formation (HP:0002722)1.77434370
159Episodic fever (HP:0001954)1.76872679
160Postaxial hand polydactyly (HP:0001162)1.76868320
161Amyotrophic lateral sclerosis (HP:0007354)1.76675359
162Prolonged partial thromboplastin time (HP:0003645)1.76601557
163Lissencephaly (HP:0001339)1.76029765
164Abnormality of fatty-acid metabolism (HP:0004359)1.76004972
165Delusions (HP:0000746)1.75326316
166Oligomenorrhea (HP:0000876)1.75127257
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.74719352
168Dyschromatopsia (HP:0007641)1.73745901
169Muscle fiber atrophy (HP:0100295)1.73346478
170Patellar aplasia (HP:0006443)1.73148303
171Type I transferrin isoform profile (HP:0003642)1.72852140
172Generalized tonic-clonic seizures (HP:0002069)1.72215671
173Bronchiectasis (HP:0002110)1.72140900
174Abolished electroretinogram (ERG) (HP:0000550)1.72132441
175Abnormality of dental color (HP:0011073)1.71717753
176Limb dystonia (HP:0002451)1.71502789
177Hypertriglyceridemia (HP:0002155)1.71496831
178EMG: myopathic abnormalities (HP:0003458)1.70504637
179Aplasia/Hypoplasia of the macula (HP:0008059)1.70411455
180Bulbar palsy (HP:0001283)1.69523528
181Myokymia (HP:0002411)1.69187411
182Increased serum lactate (HP:0002151)1.69156586
183Pancreatic cysts (HP:0001737)1.68416232
184Progressive external ophthalmoplegia (HP:0000590)1.67471559
185Abnormality of the preputium (HP:0100587)1.67008634
186Abnormal protein glycosylation (HP:0012346)1.66544961
187Abnormal glycosylation (HP:0012345)1.66544961
188Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66544961
189Abnormal protein N-linked glycosylation (HP:0012347)1.66544961
190Neck muscle weakness (HP:0000467)1.65240730
191Abnormality of renal resorption (HP:0011038)1.62768191
192Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62199086
193EEG with generalized epileptiform discharges (HP:0011198)1.61619393
194Abnormality of the renal medulla (HP:0100957)1.61513950
195Decreased testicular size (HP:0008734)1.61108278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.62381112
2CASK3.46690120
3PIM22.93637832
4PRPF4B2.92782943
5MAP3K112.91068343
6MAP2K32.85076647
7MAP2K72.64313955
8MAP3K42.58984609
9BRAF2.53464616
10PDK42.52885084
11PDK32.52885084
12BMX2.46286144
13MAP3K122.44754574
14BCKDK2.40755507
15VRK22.37670704
16MST42.31278602
17PRKD32.23486368
18ARAF2.22842929
19NTRK32.22681864
20AKT32.19325158
21TNIK2.14455890
22MAP3K92.07416001
23MAPK131.95326848
24SIK31.92544667
25RIPK41.87479313
26NTRK21.86999200
27GRK61.84123434
28MARK11.80896679
29BMPR21.75181078
30OBSCN1.74229937
31TAOK21.73490132
32BRSK11.72159314
33CCNB11.68856732
34NME21.67890778
35CDC71.67515673
36WEE11.66284055
37NME11.63049412
38ERN11.62416013
39TAOK11.52789543
40PNCK1.52385712
41MAP3K61.50318594
42PIK3CG1.45708733
43CDK81.44640466
44PBK1.43861038
45MAPKAPK31.40917055
46VRK11.37051074
47MAP3K31.35011694
48BTK1.34697680
49YES11.32227481
50CHEK21.31455827
51CSF1R1.31355230
52PDK21.29338891
53STK38L1.28105423
54PLK41.25358677
55LATS21.25286698
56MINK11.24261890
57ZAP701.18111108
58PLK31.15441459
59BRSK21.15303372
60MAPK111.15017837
61PHKG11.14140095
62PHKG21.14140095
63TSSK61.14107443
64MAP2K41.13080017
65PLK21.12893365
66EPHB11.12031954
67BLK1.11211397
68ERBB41.10153081
69BUB11.09570256
70PAK11.08861358
71AURKA1.08462711
72TTK1.08011205
73KDR1.07507567
74SYK1.07178812
75PLK11.07069663
76TBK11.06693647
77ILK1.06285460
78IRAK31.04945617
79DAPK31.02274464
80SMG10.99071496
81MAP4K10.98620710
82TRIM280.93539218
83PTK2B0.93311814
84CDK90.93234676
85MAPK120.93225193
86MAP4K20.93092735
87TTN0.92445162
88KSR10.90049315
89STK160.89737305
90WNK40.89580398
91PRKCG0.88816658
92WNK30.87703112
93MAP3K10.86883175
94MKNK20.85878924
95SGK20.85122142
96IKBKB0.84982840
97MELK0.84378592
98MAP3K50.83540902
99OXSR10.83465645
100DYRK20.82292588
101STK380.81800384
102ABL20.81765976
103PAK60.79477262
104CDK30.78691900
105MOS0.77406346
106GRK70.76988257
107TESK10.76271024
108PDPK10.74108000
109TAOK30.73861556
110ZAK0.73464528
111MATK0.70940191
112EPHA20.70352412
113EIF2AK10.70133099
114FGR0.68746392
115HCK0.67708986
116MYLK0.66748359
117LMTK20.65697217
118CDK180.65659698
119RAF10.65122392
120BMPR1B0.63277930
121PRKD10.63231445
122TLK10.63029485
123PKN10.62538316
124SGK4940.60854767
125SGK2230.60854767
126DYRK1B0.60030577
127CDK150.59421373
128CDK120.59310891
129MARK30.59303761
130NEK20.59173761
131CDK70.58049214
132DAPK10.57891283
133UHMK10.57751256
134GRK50.57559188
135PDK10.57417019
136SIK20.57336188
137LYN0.56906952
138ADRBK20.56843676
139STK390.56654872
140BRD40.54251454
141CDK140.54200024
142EPHA30.53986030
143MAPK150.53801445
144CHEK10.53464835
145RPS6KB10.53098202
146CDK11A0.52046609
147EPHA40.51769085
148SRPK10.51753784
149CSNK1G30.51390111
150MUSK0.51314917
151LIMK10.50899338
152FLT30.50676437
153TRIB30.50219252
154NEK10.50153413
155DYRK1A0.49830035
156RPS6KA50.49480562
157CDK50.49382209
158ATR0.49379629
159EEF2K0.48453846
160TNK20.48291536
161RET0.48126412
162TEC0.47826464
163CAMK2G0.45233997
164PINK10.44146630
165CAMK2A0.43480879
166CDK190.43410537
167FGFR40.43210826
168SIK10.42587020
169SGK30.41958050
170PRKD20.41775036
171KSR20.40290771
172STK240.40092916
173CDK10.39581954
174NTRK10.38092852
175ATM0.37309851

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.48066897
2Sulfur relay system_Homo sapiens_hsa041223.45841424
3Nicotine addiction_Homo sapiens_hsa050333.32226572
4Fatty acid elongation_Homo sapiens_hsa000622.96513156
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.95050815
6Oxidative phosphorylation_Homo sapiens_hsa001902.77998499
7Platelet activation_Homo sapiens_hsa046112.76368813
8Collecting duct acid secretion_Homo sapiens_hsa049662.62658680
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59070321
10Basal transcription factors_Homo sapiens_hsa030222.56114496
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.54141417
12Huntingtons disease_Homo sapiens_hsa050162.38726026
13Systemic lupus erythematosus_Homo sapiens_hsa053222.37877675
14Proteasome_Homo sapiens_hsa030502.23238463
15Parkinsons disease_Homo sapiens_hsa050122.14631866
16GABAergic synapse_Homo sapiens_hsa047272.05283605
17RNA polymerase_Homo sapiens_hsa030202.02565775
18DNA replication_Homo sapiens_hsa030301.96492885
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94947815
20Vitamin B6 metabolism_Homo sapiens_hsa007501.93733832
21Sulfur metabolism_Homo sapiens_hsa009201.91257387
22Galactose metabolism_Homo sapiens_hsa000521.90736960
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89692538
24Cell cycle_Homo sapiens_hsa041101.88495845
25Phototransduction_Homo sapiens_hsa047441.82422305
26Morphine addiction_Homo sapiens_hsa050321.75177961
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73122548
28RNA transport_Homo sapiens_hsa030131.72585127
29Fanconi anemia pathway_Homo sapiens_hsa034601.72047083
30Oocyte meiosis_Homo sapiens_hsa041141.71963938
31Glutathione metabolism_Homo sapiens_hsa004801.71897283
32Olfactory transduction_Homo sapiens_hsa047401.64941522
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61569963
34Alzheimers disease_Homo sapiens_hsa050101.57026203
35Other glycan degradation_Homo sapiens_hsa005111.53110853
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.51577247
37RNA degradation_Homo sapiens_hsa030181.51371953
38Tyrosine metabolism_Homo sapiens_hsa003501.47218828
39Mismatch repair_Homo sapiens_hsa034301.45239295
40Taste transduction_Homo sapiens_hsa047421.44116234
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42006384
42Phenylalanine metabolism_Homo sapiens_hsa003601.40687003
43Serotonergic synapse_Homo sapiens_hsa047261.40488144
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40408262
45Spliceosome_Homo sapiens_hsa030401.36080441
46Insulin secretion_Homo sapiens_hsa049111.35928265
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35556471
48Homologous recombination_Homo sapiens_hsa034401.35238781
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34974162
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34306747
51Circadian entrainment_Homo sapiens_hsa047131.33601805
52Pyrimidine metabolism_Homo sapiens_hsa002401.33501537
53Base excision repair_Homo sapiens_hsa034101.33257396
54mRNA surveillance pathway_Homo sapiens_hsa030151.31292968
55Dopaminergic synapse_Homo sapiens_hsa047281.30767377
56Shigellosis_Homo sapiens_hsa051311.28864502
57Nucleotide excision repair_Homo sapiens_hsa034201.28706685
58Amphetamine addiction_Homo sapiens_hsa050311.24769667
59Long-term potentiation_Homo sapiens_hsa047201.22069114
60Cardiac muscle contraction_Homo sapiens_hsa042601.20406060
61Purine metabolism_Homo sapiens_hsa002301.20389045
62Primary immunodeficiency_Homo sapiens_hsa053401.18348916
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18082940
64Vibrio cholerae infection_Homo sapiens_hsa051101.16218409
65Glutamatergic synapse_Homo sapiens_hsa047241.12662233
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09641262
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06601278
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06417730
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05525932
70Type I diabetes mellitus_Homo sapiens_hsa049401.05240342
71Viral carcinogenesis_Homo sapiens_hsa052031.02110089
72Calcium signaling pathway_Homo sapiens_hsa040201.00319635
73Arginine and proline metabolism_Homo sapiens_hsa003300.99305003
74Complement and coagulation cascades_Homo sapiens_hsa046100.97204571
75Alcoholism_Homo sapiens_hsa050340.96610208
76Hematopoietic cell lineage_Homo sapiens_hsa046400.96503591
77Peroxisome_Homo sapiens_hsa041460.95212648
78Arachidonic acid metabolism_Homo sapiens_hsa005900.94919229
79Fatty acid metabolism_Homo sapiens_hsa012120.94886144
80B cell receptor signaling pathway_Homo sapiens_hsa046620.93790579
81Pyruvate metabolism_Homo sapiens_hsa006200.93400453
82Folate biosynthesis_Homo sapiens_hsa007900.91958051
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91149955
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91043521
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88699124
86Endocytosis_Homo sapiens_hsa041440.88651123
87Circadian rhythm_Homo sapiens_hsa047100.88559431
88Cocaine addiction_Homo sapiens_hsa050300.86992634
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86325154
90Non-homologous end-joining_Homo sapiens_hsa034500.85852875
91PPAR signaling pathway_Homo sapiens_hsa033200.85851986
92Long-term depression_Homo sapiens_hsa047300.83988738
93Cholinergic synapse_Homo sapiens_hsa047250.81566231
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.81260075
95Fructose and mannose metabolism_Homo sapiens_hsa000510.80126688
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79746723
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77765219
98Lysosome_Homo sapiens_hsa041420.76700913
99Glucagon signaling pathway_Homo sapiens_hsa049220.75521978
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73745583
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73721741
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73686001
103Renin secretion_Homo sapiens_hsa049240.72709503
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.72534020
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71810143
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71198571
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71130827
108Regulation of autophagy_Homo sapiens_hsa041400.69726551
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69600205
110Acute myeloid leukemia_Homo sapiens_hsa052210.69560874
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69422644
112Biosynthesis of amino acids_Homo sapiens_hsa012300.69254194
113Pentose phosphate pathway_Homo sapiens_hsa000300.69217626
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68374195
115Phagosome_Homo sapiens_hsa041450.66842045
116Apoptosis_Homo sapiens_hsa042100.63368170
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.61477958
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.61286601
119Staphylococcus aureus infection_Homo sapiens_hsa051500.60548224
120Starch and sucrose metabolism_Homo sapiens_hsa005000.60370522
121Salivary secretion_Homo sapiens_hsa049700.58689114
122Non-small cell lung cancer_Homo sapiens_hsa052230.57094686
123Epstein-Barr virus infection_Homo sapiens_hsa051690.57038194
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.56941269
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56890233
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.56351587
127Fatty acid degradation_Homo sapiens_hsa000710.55877720
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55717243
129Oxytocin signaling pathway_Homo sapiens_hsa049210.53868672
130Pancreatic cancer_Homo sapiens_hsa052120.53565924
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52555820
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52370735
133Arginine biosynthesis_Homo sapiens_hsa002200.51021845
134Insulin signaling pathway_Homo sapiens_hsa049100.48901652
135One carbon pool by folate_Homo sapiens_hsa006700.47969934
136Rheumatoid arthritis_Homo sapiens_hsa053230.46677445
137Estrogen signaling pathway_Homo sapiens_hsa049150.46270620
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46163262
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45776148
140Glycerolipid metabolism_Homo sapiens_hsa005610.44997642
141Dorso-ventral axis formation_Homo sapiens_hsa043200.42211405
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41687072
143Herpes simplex infection_Homo sapiens_hsa051680.41457285
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41212773
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41060424
146Inositol phosphate metabolism_Homo sapiens_hsa005620.39945102
147Ovarian steroidogenesis_Homo sapiens_hsa049130.39038788
148Steroid biosynthesis_Homo sapiens_hsa001000.39013276
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38426312
150Gap junction_Homo sapiens_hsa045400.37800862
151Salmonella infection_Homo sapiens_hsa051320.37558313
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37145831
153Fat digestion and absorption_Homo sapiens_hsa049750.36843396
154Gastric acid secretion_Homo sapiens_hsa049710.35122538
155cAMP signaling pathway_Homo sapiens_hsa040240.34966689
156Carbon metabolism_Homo sapiens_hsa012000.34064465
157Metabolic pathways_Homo sapiens_hsa011000.33904473
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33781183
159Melanoma_Homo sapiens_hsa052180.33746789
160N-Glycan biosynthesis_Homo sapiens_hsa005100.31783012
161Fatty acid biosynthesis_Homo sapiens_hsa000610.31314444
162p53 signaling pathway_Homo sapiens_hsa041150.30936481
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30875916
164GnRH signaling pathway_Homo sapiens_hsa049120.28895560
165Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28728537
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28509108
167MAPK signaling pathway_Homo sapiens_hsa040100.25588970
168ErbB signaling pathway_Homo sapiens_hsa040120.23795168

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »