HEY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.13023178
2* Notch signaling involved in heart development (GO:0061314)5.02917794
3presynaptic membrane assembly (GO:0097105)4.82354511
4postsynaptic membrane organization (GO:0001941)4.79096119
5endothelium development (GO:0003158)4.74676228
6locomotory exploration behavior (GO:0035641)4.40186273
7presynaptic membrane organization (GO:0097090)4.33857105
8layer formation in cerebral cortex (GO:0021819)4.05603172
9* heart valve formation (GO:0003188)4.03043469
10coronary vasculature morphogenesis (GO:0060977)4.01677259
11retina vasculature morphogenesis in camera-type eye (GO:0061299)3.92223826
12* ventricular trabecula myocardium morphogenesis (GO:0003222)3.85645380
13neuronal stem cell maintenance (GO:0097150)3.66407676
14vocalization behavior (GO:0071625)3.64501342
15dendritic spine morphogenesis (GO:0060997)3.62914545
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57343734
17vascular endothelial growth factor signaling pathway (GO:0038084)3.57155611
18synaptic vesicle maturation (GO:0016188)3.53646471
19glutamate secretion (GO:0014047)3.50024142
20synaptic vesicle exocytosis (GO:0016079)3.49553226
21negative regulation of oligodendrocyte differentiation (GO:0048715)3.49416569
22astrocyte differentiation (GO:0048708)3.44329935
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43779812
24* heart trabecula morphogenesis (GO:0061384)3.42542214
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39255869
26innervation (GO:0060384)3.31778897
27axonal fasciculation (GO:0007413)3.26413474
28cell migration involved in sprouting angiogenesis (GO:0002042)3.24056367
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23010655
30basement membrane organization (GO:0071711)3.21841122
31exploration behavior (GO:0035640)3.19701272
32nephron tubule formation (GO:0072079)3.19117199
33establishment of nucleus localization (GO:0040023)3.17951172
34positive regulation of vasculogenesis (GO:2001214)3.17491880
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16732415
36regulation of somitogenesis (GO:0014807)3.16702617
37cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.12779567
38neuron cell-cell adhesion (GO:0007158)3.12688263
39cellular potassium ion homeostasis (GO:0030007)3.12220662
40neuronal action potential propagation (GO:0019227)3.10487753
41lateral sprouting from an epithelium (GO:0060601)3.10286751
42neuronal ion channel clustering (GO:0045161)3.10062622
43regulation of glutamate receptor signaling pathway (GO:1900449)3.08325599
44neuron recognition (GO:0008038)3.05150169
45regulation of synapse structural plasticity (GO:0051823)3.05051563
46establishment of mitochondrion localization (GO:0051654)3.04473878
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.04336510
48* cell surface receptor signaling pathway involved in heart development (GO:0061311)3.04208523
49cardiac muscle cell proliferation (GO:0060038)3.04182907
50regulation of neuronal synaptic plasticity (GO:0048168)3.02738637
51striated muscle cell proliferation (GO:0014855)3.02307359
52cell-cell signaling involved in cell fate commitment (GO:0045168)2.99872015
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92354165
54negative regulation of astrocyte differentiation (GO:0048712)2.92076653
55axon extension involved in axon guidance (GO:0048846)2.88899098
56neuron projection extension involved in neuron projection guidance (GO:1902284)2.88899098
57* regulation of vasculogenesis (GO:2001212)2.88783283
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88645472
59proximal/distal pattern formation (GO:0009954)2.87456194
60transmission of nerve impulse (GO:0019226)2.86936013
61oligodendrocyte differentiation (GO:0048709)2.84833566
62protein localization to synapse (GO:0035418)2.84721548
63astrocyte development (GO:0014002)2.82397362
64long-term synaptic potentiation (GO:0060291)2.81500981
65* endocardial cushion morphogenesis (GO:0003203)2.79806538
66* endothelial cell differentiation (GO:0045446)2.78017386
67limb bud formation (GO:0060174)2.76804429
68central nervous system myelination (GO:0022010)2.76067675
69axon ensheathment in central nervous system (GO:0032291)2.76067675
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75312999
71regulation of axon extension involved in axon guidance (GO:0048841)2.75282642
72neurotransmitter-gated ion channel clustering (GO:0072578)2.75024036
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.74847499
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.74733523
75negative regulation of vascular permeability (GO:0043116)2.74719913
76* trabecula morphogenesis (GO:0061383)2.74042682
77cochlea development (GO:0090102)2.73487234
78developmental induction (GO:0031128)2.72881810
79muscle cell proliferation (GO:0033002)2.72733294
80cell communication by electrical coupling (GO:0010644)2.72629154
81dermatan sulfate biosynthetic process (GO:0030208)2.71091772
82auditory behavior (GO:0031223)2.70304363
83peripheral nervous system neuron development (GO:0048935)2.70260323
84photoreceptor cell differentiation (GO:0046530)2.69517040
85eye photoreceptor cell differentiation (GO:0001754)2.69517040
86positive regulation of synapse maturation (GO:0090129)2.69205883
87glutamate receptor signaling pathway (GO:0007215)2.68539768
88regulation of axon guidance (GO:1902667)2.68517852
89sprouting angiogenesis (GO:0002040)2.68146115
90axon extension (GO:0048675)2.67974692
91lung epithelium development (GO:0060428)2.67565646
92regulation of synaptic vesicle exocytosis (GO:2000300)2.67080310
93cerebellar granule cell differentiation (GO:0021707)2.66619853
94regulation of dendritic spine morphogenesis (GO:0061001)2.65397259
95lens fiber cell development (GO:0070307)2.65277022
96negative regulation of axon guidance (GO:1902668)2.64471940
97nonmotile primary cilium assembly (GO:0035058)2.64094685
98dendritic spine organization (GO:0097061)2.62398306
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62229898
100response to auditory stimulus (GO:0010996)2.61612935
101synaptic transmission, glutamatergic (GO:0035249)2.61399519
102embryonic heart tube development (GO:0035050)2.60165648
103regulation of astrocyte differentiation (GO:0048710)2.59339146
104regulation of synaptic plasticity (GO:0048167)2.58637799
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57421107
106neurotransmitter secretion (GO:0007269)2.56996707
107sodium ion export (GO:0071436)2.56926012
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56892860
109regulation of cardioblast proliferation (GO:0003264)2.56329732
110regulation of secondary heart field cardioblast proliferation (GO:0003266)2.56329732
111mechanosensory behavior (GO:0007638)2.56274829
112negative regulation of axon extension (GO:0030517)2.56226112
113startle response (GO:0001964)2.55651342
114Notch receptor processing (GO:0007220)2.55038898
115dendrite morphogenesis (GO:0048813)2.54885202
116mesenchymal cell development (GO:0014031)2.54247302
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.53793992
118renal tubule morphogenesis (GO:0061333)2.53381617
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.52165040
120forebrain neuron differentiation (GO:0021879)2.51897364
121regulation of heart morphogenesis (GO:2000826)2.51585535
122neuron remodeling (GO:0016322)2.50851996
123potassium ion import (GO:0010107)2.49021154
124glial cell differentiation (GO:0010001)2.48607172
125establishment of tissue polarity (GO:0007164)2.48170091
126establishment of planar polarity (GO:0001736)2.48170091
127long-term memory (GO:0007616)2.47823444
128regulation of development, heterochronic (GO:0040034)2.47692419
129neuron-neuron synaptic transmission (GO:0007270)2.47166215
130cochlea morphogenesis (GO:0090103)2.46865957
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46808406
132neuron projection regeneration (GO:0031102)2.46711379
133dermatan sulfate metabolic process (GO:0030205)2.46311299
134L-amino acid import (GO:0043092)2.45552872
135patterning of blood vessels (GO:0001569)2.45354566
136ganglion development (GO:0061548)2.45246735
137retinal ganglion cell axon guidance (GO:0031290)2.44826280
138neuromuscular process controlling balance (GO:0050885)2.43728331
139negative regulation of glial cell differentiation (GO:0045686)2.43126286
140blood vessel endothelial cell migration (GO:0043534)2.42507636
141regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.42493468
142cranial nerve development (GO:0021545)2.42491280
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42374777
144synapse assembly (GO:0007416)2.41956529
145cell migration in hindbrain (GO:0021535)2.41624969
146proline transport (GO:0015824)2.41295904
147mechanoreceptor differentiation (GO:0042490)2.39989046
148regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.36524982
149collecting duct development (GO:0072044)2.35820138
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34726635
151synapse organization (GO:0050808)2.34597436
152neuroblast proliferation (GO:0007405)2.34555120
153regulation of voltage-gated calcium channel activity (GO:1901385)2.34018697
154central nervous system projection neuron axonogenesis (GO:0021952)2.32711436
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.32072206
156behavioral defense response (GO:0002209)2.31020861
157behavioral fear response (GO:0001662)2.31020861
158regulation of synaptic transmission, glutamatergic (GO:0051966)2.30334532
159regulation of synaptic vesicle transport (GO:1902803)2.29987106
160regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29164023
161membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.27190944
162prepulse inhibition (GO:0060134)2.25526489
163membrane repolarization (GO:0086009)2.25458908
164regulation of postsynaptic membrane potential (GO:0060078)2.25453272
165activation of protein kinase A activity (GO:0034199)2.25050211
166regulation of synapse maturation (GO:0090128)2.24905237
167fear response (GO:0042596)2.24449634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20450530
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18148439
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10949413
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.01688391
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.01688391
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00359614
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.91989422
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.82673524
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.79199091
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78052578
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70622478
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64719594
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.54141861
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42531138
15GBX2_23144817_ChIP-Seq_PC3_Human2.34728660
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26458428
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25772983
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24605724
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20063770
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18176786
21DROSHA_22980978_ChIP-Seq_HELA_Human2.05710271
22AR_21572438_ChIP-Seq_LNCaP_Human1.96100441
23* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93123026
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85384279
25* RING1B_27294783_Chip-Seq_ESCs_Mouse1.74094904
26* RARB_27405468_Chip-Seq_BRAIN_Mouse1.69875044
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67134059
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.66915648
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66824007
30REST_21632747_ChIP-Seq_MESCs_Mouse1.65799345
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.64500231
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.63972152
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63907328
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.61729572
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.61637547
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57123020
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56024184
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50610385
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50294847
40TAF15_26573619_Chip-Seq_HEK293_Human1.48368613
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46905452
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42298337
43* TRIM28_21343339_ChIP-Seq_HEK293_Human1.41694334
44* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41158123
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.40456688
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40265320
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38835501
48* AHR_22903824_ChIP-Seq_MCF-7_Human1.38465331
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36238651
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35554400
51CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34733228
52EWS_26573619_Chip-Seq_HEK293_Human1.34524306
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.32181349
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.31124810
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29748561
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28874020
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.27411117
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.27257614
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27255365
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25673186
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.24925656
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24248178
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.24166491
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24035530
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23750750
66CLOCK_20551151_ChIP-Seq_293T_Human1.21684131
67* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20959420
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18816914
69P300_19829295_ChIP-Seq_ESCs_Human1.18466718
70KDM2B_26808549_Chip-Seq_K562_Human1.17977405
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.17901762
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17578076
73* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16815200
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16298293
75SOX9_26525672_Chip-Seq_HEART_Mouse1.15821719
76TP53_18474530_ChIP-ChIP_U2OS_Human1.14510241
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14404027
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14282797
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.14230869
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13256717
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13101878
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12672101
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12502869
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12073904
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11015276
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10450455
87BCAT_22108803_ChIP-Seq_LS180_Human1.09309018
88* ESR2_21235772_ChIP-Seq_MCF-7_Human1.08803864
89AR_19668381_ChIP-Seq_PC3_Human1.08766943
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08556144
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.07855841
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07759727
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07526588
94* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07259715
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07173832
96AR_25329375_ChIP-Seq_VCAP_Human1.06690672
97TP53_16413492_ChIP-PET_HCT116_Human1.06528569
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.05720985
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05415630
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04571488
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04403522
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03232189
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02226560
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02226560
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02221478
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01995777
107* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01846436
108RNF2_27304074_Chip-Seq_NSC_Mouse1.01743963
109* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00857797
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99875850
111GATA1_26923725_Chip-Seq_HPCs_Mouse0.98961047
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98872721
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.97995628
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96196908
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95874088
116FUS_26573619_Chip-Seq_HEK293_Human0.95647166
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.95503166
118ZNF274_21170338_ChIP-Seq_K562_Hela0.94552760
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.94378465
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93984703
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93810498
122RXR_22108803_ChIP-Seq_LS180_Human0.93797794
123* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92135874
124* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91290396
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90564288
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89408800
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87335932
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.83800156
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83306054
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83077649
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83077649
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83077649
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82648045
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82113243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.99823710
2MP0003880_abnormal_central_pattern3.63007372
3MP0003136_yellow_coat_color3.44566019
4MP0003635_abnormal_synaptic_transmissio2.65092587
5MP0010030_abnormal_orbit_morphology2.64988245
6MP0000566_synostosis2.38387696
7MP0000778_abnormal_nervous_system2.34843296
8MP0009780_abnormal_chondrocyte_physiolo2.31224864
9MP0002063_abnormal_learning/memory/cond2.14651470
10MP0009745_abnormal_behavioral_response2.14005170
11MP0002653_abnormal_ependyma_morphology2.06655398
12MP0004270_analgesia2.04925265
13MP0001486_abnormal_startle_reflex1.93897750
14MP0002064_seizures1.93022087
15MP0004858_abnormal_nervous_system1.91585891
16MP0005394_taste/olfaction_phenotype1.87291021
17MP0005499_abnormal_olfactory_system1.87291021
18MP0004885_abnormal_endolymph1.78490993
19MP0008789_abnormal_olfactory_epithelium1.75587565
20MP0005423_abnormal_somatic_nervous1.72342040
21MP0005367_renal/urinary_system_phenotyp1.70037948
22MP0000516_abnormal_urinary_system1.70037948
23MP0000537_abnormal_urethra_morphology1.69844868
24MP0002572_abnormal_emotion/affect_behav1.68617133
25MP0001968_abnormal_touch/_nociception1.65274113
26MP0002697_abnormal_eye_size1.62692733
27MP0002272_abnormal_nervous_system1.62329759
28MP0000534_abnormal_ureter_morphology1.61977043
29MP0005167_abnormal_blood-brain_barrier1.61650120
30MP0005171_absent_coat_pigmentation1.56164527
31MP0003122_maternal_imprinting1.54074738
32MP0001984_abnormal_olfaction1.53576684
33MP0001485_abnormal_pinna_reflex1.50253716
34MP0000049_abnormal_middle_ear1.48660251
35MP0002184_abnormal_innervation1.44303204
36MP0000955_abnormal_spinal_cord1.43745814
37MP0002734_abnormal_mechanical_nocicepti1.43707429
38MP0010368_abnormal_lymphatic_system1.43481894
39MP0004272_abnormal_basement_membrane1.43039087
40MP0002249_abnormal_larynx_morphology1.42629475
41MP0005623_abnormal_meninges_morphology1.40924018
42MP0000026_abnormal_inner_ear1.40583494
43MP0009046_muscle_twitch1.40135790
44MP0001529_abnormal_vocalization1.38810286
45MP0005646_abnormal_pituitary_gland1.38779900
46MP0005248_abnormal_Harderian_gland1.38055296
47MP0003942_abnormal_urinary_system1.36343478
48MP0002822_catalepsy1.35965616
49MP0002877_abnormal_melanocyte_morpholog1.34263725
50MP0002557_abnormal_social/conspecific_i1.32367074
51MP0002736_abnormal_nociception_after1.31674664
52MP0009053_abnormal_anal_canal1.30440361
53MP0002067_abnormal_sensory_capabilities1.28993862
54MP0002092_abnormal_eye_morphology1.28072310
55MP0008569_lethality_at_weaning1.27238853
56MP0003879_abnormal_hair_cell1.23341339
57MP0002234_abnormal_pharynx_morphology1.22909987
58* MP0002882_abnormal_neuron_morphology1.22491085
59MP0003938_abnormal_ear_development1.21936504
60MP0001346_abnormal_lacrimal_gland1.19047317
61MP0005187_abnormal_penis_morphology1.18930045
62MP0009250_abnormal_appendicular_skeleto1.18381346
63MP0001501_abnormal_sleep_pattern1.16850086
64MP0002282_abnormal_trachea_morphology1.16113408
65MP0003385_abnormal_body_wall1.15423590
66MP0001299_abnormal_eye_distance/1.13135368
67MP0003115_abnormal_respiratory_system1.13055168
68MP0004811_abnormal_neuron_physiology1.11956064
69MP0002751_abnormal_autonomic_nervous1.11651654
70* MP0002152_abnormal_brain_morphology1.10567033
71MP0002233_abnormal_nose_morphology1.09951927
72* MP0003861_abnormal_nervous_system1.09885877
73MP0005377_hearing/vestibular/ear_phenot1.09444606
74MP0003878_abnormal_ear_physiology1.09444606
75MP0001440_abnormal_grooming_behavior1.09119424
76MP0002638_abnormal_pupillary_reflex1.08865396
77MP0000631_abnormal_neuroendocrine_gland1.08124073
78MP0001963_abnormal_hearing_physiology1.07211530
79* MP0003935_abnormal_craniofacial_develop1.06340428
80MP0004924_abnormal_behavior1.03536597
81MP0005386_behavior/neurological_phenoty1.03536597
82MP0006276_abnormal_autonomic_nervous1.03156811
83MP0005391_vision/eye_phenotype1.02882750
84MP0000762_abnormal_tongue_morphology1.02539506
85MP0002909_abnormal_adrenal_gland1.01142796
86MP0001879_abnormal_lymphatic_vessel1.01039877
87MP0003315_abnormal_perineum_morphology1.00796229
88MP0004085_abnormal_heartbeat0.97499871
89MP0001177_atelectasis0.97330174
90MP0000428_abnormal_craniofacial_morphol0.96551694
91MP0010234_abnormal_vibrissa_follicle0.95709254
92MP0001502_abnormal_circadian_rhythm0.95266094
93MP0004742_abnormal_vestibular_system0.94766788
94MP0001286_abnormal_eye_development0.94691778
95MP0008961_abnormal_basal_metabolism0.94285135
96MP0002733_abnormal_thermal_nociception0.93269710
97MP0003937_abnormal_limbs/digits/tail_de0.92695218
98MP0003283_abnormal_digestive_organ0.91220604
99MP0005503_abnormal_tendon_morphology0.89816706
100MP0001293_anophthalmia0.89408502
101MP0003755_abnormal_palate_morphology0.89239733
102MP0003634_abnormal_glial_cell0.89035680
103* MP0002752_abnormal_somatic_nervous0.87623948
104MP0002116_abnormal_craniofacial_bone0.87516975
105MP0001905_abnormal_dopamine_level0.87499916
106MP0001915_intracranial_hemorrhage0.87341733
107MP0003329_amyloid_beta_deposits0.86764009
108MP0002081_perinatal_lethality0.86695716
109MP0003690_abnormal_glial_cell0.86408505
110MP0000647_abnormal_sebaceous_gland0.86204757
111MP0003119_abnormal_digestive_system0.85957326
112MP0001970_abnormal_pain_threshold0.85638957
113MP0001188_hyperpigmentation0.85250740
114MP0002066_abnormal_motor_capabilities/c0.85173095
115MP0003941_abnormal_skin_development0.84491742
116MP0002735_abnormal_chemical_nociception0.82872730
117MP0002938_white_spotting0.82369284
118MP0005084_abnormal_gallbladder_morpholo0.82220526
119MP0001270_distended_abdomen0.81998558
120MP0002932_abnormal_joint_morphology0.81953189
121MP0005595_abnormal_vascular_smooth0.76556091
122MP0000733_abnormal_muscle_development0.76222227
123MP0005197_abnormal_uvea_morphology0.74570894
124MP0005508_abnormal_skeleton_morphology0.73998132
125MP0000767_abnormal_smooth_muscle0.72318844

Predicted human phenotypes

RankGene SetZ-score
1Hemiplegia (HP:0002301)4.86304067
2Hypoplasia of the iris (HP:0007676)3.92108374
3Aplasia involving bones of the extremities (HP:0009825)3.90258341
4Aplasia involving bones of the upper limbs (HP:0009823)3.90258341
5Aplasia of the phalanges of the hand (HP:0009802)3.90258341
6Focal motor seizures (HP:0011153)3.79063222
7Myokymia (HP:0002411)3.78236894
8Hemiparesis (HP:0001269)3.64151671
9Megalencephaly (HP:0001355)3.59163549
10Synostosis involving the elbow (HP:0003938)3.24420500
11Humeroradial synostosis (HP:0003041)3.24420500
12Focal seizures (HP:0007359)2.91170356
13Mixed hearing impairment (HP:0000410)2.79231786
14Exotropia (HP:0000577)2.72160756
15Occipital encephalocele (HP:0002085)2.64292243
16Bronchomalacia (HP:0002780)2.63237001
17Cerebral aneurysm (HP:0004944)2.60806561
18Broad distal phalanx of finger (HP:0009836)2.59776327
19Gastrointestinal atresia (HP:0002589)2.59591138
20Abnormality of the middle phalanges of the toes (HP:0010183)2.58797808
21Adactyly (HP:0009776)2.54106057
22Alacrima (HP:0000522)2.51243751
23Progressive cerebellar ataxia (HP:0002073)2.50458702
24Tetraparesis (HP:0002273)2.40797964
25Action tremor (HP:0002345)2.39549861
26Double outlet right ventricle (HP:0001719)2.37813833
27Congenital malformation of the right heart (HP:0011723)2.37813833
28Renal dysplasia (HP:0000110)2.35204858
29Thickened helices (HP:0000391)2.33100998
30Abnormality of the lower motor neuron (HP:0002366)2.31981842
31Atonic seizures (HP:0010819)2.29834593
32Vertebral arch anomaly (HP:0008438)2.29499798
33Pheochromocytoma (HP:0002666)2.29204309
34Epileptic encephalopathy (HP:0200134)2.28298144
35Cortical dysplasia (HP:0002539)2.27370908
36Oligodactyly (HP:0012165)2.27241575
37Anophthalmia (HP:0000528)2.26382828
38Elfin facies (HP:0004428)2.24857317
39Abnormal number of incisors (HP:0011064)2.22961271
40Annular pancreas (HP:0001734)2.20459726
41Abnormality of the phalanges of the hallux (HP:0010057)2.19337147
42Visual hallucinations (HP:0002367)2.19077233
43Coronal craniosynostosis (HP:0004440)2.17354750
44Split foot (HP:0001839)2.16670947
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16248780
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.11695131
47Midline defect of the nose (HP:0004122)2.11565119
48Transposition of the great arteries (HP:0001669)2.09946219
49Abnormal connection of the cardiac segments (HP:0011545)2.09946219
50Abnormal ventriculo-arterial connection (HP:0011563)2.09946219
51Short 4th metacarpal (HP:0010044)2.09171351
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09171351
53Wide anterior fontanel (HP:0000260)2.06983498
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.06853715
55Trigonocephaly (HP:0000243)2.06055542
56Esophageal atresia (HP:0002032)2.05812713
57Shallow orbits (HP:0000586)2.05240234
58Abnormality of the fetal cardiovascular system (HP:0010948)2.04936775
59Abnormal umbilical cord blood vessels (HP:0011403)2.04936775
60Single umbilical artery (HP:0001195)2.04936775
61Aqueductal stenosis (HP:0002410)2.04824140
62Porencephaly (HP:0002132)2.04451758
63Arterial tortuosity (HP:0005116)2.04093135
64Missing ribs (HP:0000921)2.03438827
65Hyperventilation (HP:0002883)2.02715314
66Oligodactyly (hands) (HP:0001180)2.02693367
67Abnormality of the ischium (HP:0003174)2.00170663
68Absence seizures (HP:0002121)1.99814212
69Periauricular skin pits (HP:0100277)1.99069387
70Preauricular pit (HP:0004467)1.99069387
71Decreased lacrimation (HP:0000633)1.97292780
72Germ cell neoplasia (HP:0100728)1.94403938
73Abnormality of the lacrimal duct (HP:0011481)1.92236427
74Neoplasm of the heart (HP:0100544)1.92138120
75Neurofibrillary tangles (HP:0002185)1.92003296
76Broad-based gait (HP:0002136)1.91443065
77Calcaneovalgus deformity (HP:0001848)1.91402677
78Bilateral microphthalmos (HP:0007633)1.90111231
79Hypopigmentation of the fundus (HP:0007894)1.89420120
80Thin ribs (HP:0000883)1.88908320
81Skull defect (HP:0001362)1.88556357
82Down-sloping shoulders (HP:0200021)1.87353765
83Scotoma (HP:0000575)1.86858587
84Retinal dysplasia (HP:0007973)1.84965650
85Neuroendocrine neoplasm (HP:0100634)1.83326812
86Amblyopia (HP:0000646)1.82948054
87Nonimmune hydrops fetalis (HP:0001790)1.82719082
88Bifid scrotum (HP:0000048)1.82529933
89Aplasia cutis congenita (HP:0001057)1.82039515
90Vascular tortuosity (HP:0004948)1.81772307
91Labial hypoplasia (HP:0000066)1.80411446
92Potter facies (HP:0002009)1.79490186
93Facial shape deformation (HP:0011334)1.79490186
94Ulnar bowing (HP:0003031)1.78757579
95Pulmonary artery stenosis (HP:0004415)1.77167915
96Cupped ear (HP:0000378)1.75562114
97Generalized tonic-clonic seizures (HP:0002069)1.75272150
98Vertebral hypoplasia (HP:0008417)1.75253773
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.75253773
100Abnormality of the antihelix (HP:0009738)1.75071220
101Abnormality of the vitreous humor (HP:0004327)1.74755841
102Genetic anticipation (HP:0003743)1.74041735
103Abnormality of the aortic arch (HP:0012303)1.72660464
104Nasolacrimal duct obstruction (HP:0000579)1.72341089
105Abnormality of the nasolacrimal system (HP:0000614)1.71978721
106Hypoplastic nipples (HP:0002557)1.71777788
107Abnormality of the pulmonary veins (HP:0011718)1.71707356
108Hydroureter (HP:0000072)1.71014465
109Spastic diplegia (HP:0001264)1.70687712
110Abnormality of the parietal bone (HP:0002696)1.69473712
111Short middle phalanx of the 5th finger (HP:0004220)1.68800691
112Abnormality of the anterior chamber (HP:0000593)1.68233013
113Deformed tarsal bones (HP:0008119)1.67202248
114Abnormality of the 4th metacarpal (HP:0010012)1.67130151
115Sacral dimple (HP:0000960)1.66783593
116Large earlobe (HP:0009748)1.66598224
117Overriding aorta (HP:0002623)1.66479744
118Preaxial hand polydactyly (HP:0001177)1.65987449
119Anxiety (HP:0000739)1.65855361
120Short hallux (HP:0010109)1.65695210
121Febrile seizures (HP:0002373)1.64995618
122Cutaneous finger syndactyly (HP:0010554)1.64824443
123Abnormality of the left ventricular outflow tract (HP:0011103)1.64763832
124Subaortic stenosis (HP:0001682)1.64763832
125Morphological abnormality of the middle ear (HP:0008609)1.63471696
126Anterior segment dysgenesis (HP:0007700)1.63256667
127Preaxial foot polydactyly (HP:0001841)1.63147475
128Incomplete penetrance (HP:0003829)1.62783592
129Radioulnar synostosis (HP:0002974)1.62266407
130Abnormality of chromosome segregation (HP:0002916)1.62068105
131Anomalous pulmonary venous return (HP:0010772)1.61969971
132Abnormality of the pubic bones (HP:0003172)1.61933278
133Vertebral clefting (HP:0008428)1.60480034
134Drooling (HP:0002307)1.60465059
135Excessive salivation (HP:0003781)1.60465059
136Renal hypoplasia (HP:0000089)1.60182434
137Broad toe (HP:0001837)1.59743488
138Absent hand (HP:0004050)1.59610342
139Cerebral inclusion bodies (HP:0100314)1.59477161
140Supernumerary ribs (HP:0005815)1.59240729
141Fibular hypoplasia (HP:0003038)1.58985475
142Arnold-Chiari malformation (HP:0002308)1.58852320
143Dialeptic seizures (HP:0011146)1.58757052
144Partial duplication of thumb phalanx (HP:0009944)1.58559094
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.57979295
146High anterior hairline (HP:0009890)1.57525049
147Abnormality of the right ventricle (HP:0001707)1.56950050
148Obstructive sleep apnea (HP:0002870)1.56788654
149Morphological abnormality of the inner ear (HP:0011390)1.55690971
150Hemivertebrae (HP:0002937)1.55128393
151Anencephaly (HP:0002323)1.54984330
152Hypoplastic female external genitalia (HP:0012815)1.54641925
153Skin pits (HP:0100276)1.54525910
154Absent toe (HP:0010760)1.54313088
155Absent phalangeal crease (HP:0006109)1.54204808
156Limb dystonia (HP:0002451)1.53743497
157Broad metatarsal (HP:0001783)1.53737067
158Aplasia/Hypoplasia of the hallux (HP:0008362)1.52735484
159Narrow nasal bridge (HP:0000446)1.51556503
160Anosmia (HP:0000458)1.50353785
161Dysdiadochokinesis (HP:0002075)1.50071502
162Fibular aplasia (HP:0002990)1.49710388
163Scanning speech (HP:0002168)1.49019247
164Broad hallux (HP:0010055)1.47414482
165Absent eyebrow (HP:0002223)1.47267774
166Cutaneous syndactyly (HP:0012725)1.46518078
167Neonatal short-limb short stature (HP:0008921)1.46356615
168Abnormality of the diencephalon (HP:0010662)1.46109689
169Partial duplication of the phalanx of hand (HP:0009999)1.44965903
170Abnormal eating behavior (HP:0100738)1.43501614
171Termporal pattern (HP:0011008)1.42935517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.36780513
2EPHA43.89320340
3EPHB23.08514245
4NTRK33.01085845
5MAPK152.98466273
6INSRR2.83439133
7KSR12.75169877
8PRKD32.53221693
9MAP3K42.40330324
10TSSK62.29448431
11MINK12.16546046
12WEE12.14489408
13NTRK22.14449037
14MAP3K92.11008680
15CASK1.90969573
16PAK61.86221563
17MOS1.84569338
18TYRO31.73330775
19DAPK21.69557746
20NTRK11.68767469
21DDR21.67694292
22TNIK1.67281716
23TIE11.66044640
24UHMK11.65746405
25MARK11.65542943
26PLK21.64909265
27CAMKK11.64118559
28KSR21.62796154
29MAP2K71.53757454
30BCR1.52658908
31LATS21.47856120
32DMPK1.42439999
33PTK2B1.40078409
34MAPK131.34757628
35FER1.34181439
36MAP3K21.30556938
37PAK31.29451712
38ARAF1.26030249
39CDK51.25874088
40TRIM281.25714629
41LMTK21.25221817
42SGK4941.17782153
43SGK2231.17782153
44SIK31.13926723
45ROCK21.11128222
46YES11.10858327
47MKNK21.08676302
48PKN11.07402216
49ERBB21.06998119
50STK381.06091449
51FGFR21.05066648
52MAP2K41.03895284
53SGK21.02900981
54PHKG21.02796764
55PHKG11.02796764
56TRIB31.01912278
57CDK30.98845174
58MKNK10.97975552
59PRPF4B0.96465612
60RIPK10.95767192
61PNCK0.94051755
62RET0.93885988
63CDK180.93806006
64CDK140.93791492
65CSNK1G30.93676809
66NEK60.92907011
67SIK20.90849786
68BRD40.89171701
69TAOK10.88658016
70RPS6KA40.85275193
71CDK150.85226246
72FGFR10.84840466
73CAMK2A0.84691612
74PDGFRA0.83610400
75NEK20.80801306
76CSNK1G10.79453078
77RAF10.79407224
78MAP3K100.76503460
79CDK120.76405742
80ROCK10.75859411
81PRKCG0.74197634
82CDK11A0.73591860
83LATS10.72116484
84DYRK1A0.71933158
85DYRK20.70635388
86SGK30.68598886
87CSNK1G20.67465154
88GRK50.67040445
89CDC70.66041038
90SRPK10.65262116
91MAP3K120.65056198
92CCNB10.63587266
93BUB10.62174194
94STK160.61376847
95MAP2K10.61121348
96SGK10.60974274
97CDK190.60625123
98WNK30.60310240
99MAPKAPK50.59448440
100MELK0.56860773
101CDC42BPA0.56823514
102PRKCE0.56368856
103AKT20.56013739
104DAPK10.55984330
105PRKCZ0.55739634
106BMPR1B0.54258944
107CAMK10.53261138
108BRSK10.53046589
109STK390.52535477
110CAMK1G0.52421848
111CAMK2B0.52345479
112SIK10.52223097
113FGFR30.52047821
114BMPR20.51824114
115PRKCH0.51601841
116ICK0.50249632
117PKN20.50215583
118PLK30.50125115
119PTK20.49204216
120EPHA30.49185228
121ERBB40.48572708
122STK110.47495896
123RIPK40.45967641
124PLK40.45647897
125CAMK1D0.45442623
126CSNK1A1L0.44972819
127ERBB30.43997804
128FES0.43797549
129BCKDK0.43528405
130FGR0.42950230
131AURKA0.42220036
132MAPK100.41750379
133NEK10.41061251
134PAK40.40394283
135VRK10.40252235
136BMX0.39867380
137MAP3K70.39048492
138RPS6KA30.38052825
139OXSR10.37528290
140CAMK2D0.37415333
141MATK0.37362169
142CAMK2G0.37292983
143CDK80.36659122
144FYN0.35656304
145PAK20.35418009
146MAP3K10.34744933
147DYRK30.31183088
148IRAK20.31027070
149CSNK1E0.30256264
150PDGFRB0.28871308

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.54803505
2Circadian entrainment_Homo sapiens_hsa047132.16922217
3Synaptic vesicle cycle_Homo sapiens_hsa047212.13842361
4Glutamatergic synapse_Homo sapiens_hsa047242.11697821
5Amphetamine addiction_Homo sapiens_hsa050312.07028699
6Long-term potentiation_Homo sapiens_hsa047202.06485864
7Olfactory transduction_Homo sapiens_hsa047402.03917828
8GABAergic synapse_Homo sapiens_hsa047272.00658705
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94500173
10Salivary secretion_Homo sapiens_hsa049701.91238409
11Axon guidance_Homo sapiens_hsa043601.90636957
12Gastric acid secretion_Homo sapiens_hsa049711.87956497
13Morphine addiction_Homo sapiens_hsa050321.82291924
14Dopaminergic synapse_Homo sapiens_hsa047281.78061275
15Cholinergic synapse_Homo sapiens_hsa047251.71604351
16Sulfur relay system_Homo sapiens_hsa041221.67315589
17Dorso-ventral axis formation_Homo sapiens_hsa043201.67284718
18Basal cell carcinoma_Homo sapiens_hsa052171.63700241
19Melanogenesis_Homo sapiens_hsa049161.61893707
20Renin secretion_Homo sapiens_hsa049241.60662981
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57360177
22Cocaine addiction_Homo sapiens_hsa050301.56504540
23Gap junction_Homo sapiens_hsa045401.53375408
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53064374
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51456327
26Oxytocin signaling pathway_Homo sapiens_hsa049211.50434363
27Long-term depression_Homo sapiens_hsa047301.48708584
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44486806
29Insulin secretion_Homo sapiens_hsa049111.43932613
30Nitrogen metabolism_Homo sapiens_hsa009101.42709000
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42304916
32Hippo signaling pathway_Homo sapiens_hsa043901.41683801
33Hedgehog signaling pathway_Homo sapiens_hsa043401.40005998
34Notch signaling pathway_Homo sapiens_hsa043301.37503637
35Spliceosome_Homo sapiens_hsa030401.32986373
36Estrogen signaling pathway_Homo sapiens_hsa049151.30797523
37GnRH signaling pathway_Homo sapiens_hsa049121.30375840
38Calcium signaling pathway_Homo sapiens_hsa040201.27694488
39Taste transduction_Homo sapiens_hsa047421.25851566
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25158665
41Glioma_Homo sapiens_hsa052141.24846785
42Serotonergic synapse_Homo sapiens_hsa047261.23629321
43Wnt signaling pathway_Homo sapiens_hsa043101.22361725
44Dilated cardiomyopathy_Homo sapiens_hsa054141.21867627
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18950721
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18891365
47cAMP signaling pathway_Homo sapiens_hsa040241.18763798
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18413516
49Protein digestion and absorption_Homo sapiens_hsa049741.17743887
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15291988
51Folate biosynthesis_Homo sapiens_hsa007901.13253503
52Protein export_Homo sapiens_hsa030601.08599949
53ErbB signaling pathway_Homo sapiens_hsa040121.07946682
54Steroid biosynthesis_Homo sapiens_hsa001001.07334692
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05482056
56Collecting duct acid secretion_Homo sapiens_hsa049661.03451405
57Cardiac muscle contraction_Homo sapiens_hsa042601.03321935
58Renal cell carcinoma_Homo sapiens_hsa052111.01374072
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00520540
60Rap1 signaling pathway_Homo sapiens_hsa040151.00448208
61Tight junction_Homo sapiens_hsa045300.99355151
62Oocyte meiosis_Homo sapiens_hsa041140.97967821
63Adherens junction_Homo sapiens_hsa045200.96817066
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95846520
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95452722
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94165950
67Circadian rhythm_Homo sapiens_hsa047100.93695814
68TGF-beta signaling pathway_Homo sapiens_hsa043500.92523023
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92066950
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91533322
71Endometrial cancer_Homo sapiens_hsa052130.91515703
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87926064
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.86732299
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86332172
75MAPK signaling pathway_Homo sapiens_hsa040100.85734163
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84890466
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84238975
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81993635
79Alzheimers disease_Homo sapiens_hsa050100.81970494
80Colorectal cancer_Homo sapiens_hsa052100.81875111
81Parkinsons disease_Homo sapiens_hsa050120.81661850
82Proteoglycans in cancer_Homo sapiens_hsa052050.80103939
83mRNA surveillance pathway_Homo sapiens_hsa030150.79705952
84Cell cycle_Homo sapiens_hsa041100.77694048
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77578281
86VEGF signaling pathway_Homo sapiens_hsa043700.77524847
87Ras signaling pathway_Homo sapiens_hsa040140.77521123
88Choline metabolism in cancer_Homo sapiens_hsa052310.76754726
89Huntingtons disease_Homo sapiens_hsa050160.76710319
90Focal adhesion_Homo sapiens_hsa045100.75037857
91HIF-1 signaling pathway_Homo sapiens_hsa040660.74405856
92Vibrio cholerae infection_Homo sapiens_hsa051100.74103727
93Small cell lung cancer_Homo sapiens_hsa052220.73818454
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71266865
95Melanoma_Homo sapiens_hsa052180.71092027
96Thyroid hormone synthesis_Homo sapiens_hsa049180.71042398
97Type II diabetes mellitus_Homo sapiens_hsa049300.70155606
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67327296
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66661370
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66232280
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.66197873
102MicroRNAs in cancer_Homo sapiens_hsa052060.65320754
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64443528
104Non-small cell lung cancer_Homo sapiens_hsa052230.64343188
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62285367
106AMPK signaling pathway_Homo sapiens_hsa041520.60587195
107Pancreatic secretion_Homo sapiens_hsa049720.60192937
108Bladder cancer_Homo sapiens_hsa052190.58546765
109Prion diseases_Homo sapiens_hsa050200.58536012
110Pathways in cancer_Homo sapiens_hsa052000.57668047
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56176969
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.55946137
113ECM-receptor interaction_Homo sapiens_hsa045120.55803579
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54196551
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53865472
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51572108
117Bile secretion_Homo sapiens_hsa049760.51029170
118Endocytosis_Homo sapiens_hsa041440.50270772
119Glucagon signaling pathway_Homo sapiens_hsa049220.48963944
120Pancreatic cancer_Homo sapiens_hsa052120.48219113
121Chronic myeloid leukemia_Homo sapiens_hsa052200.48063778
122Prostate cancer_Homo sapiens_hsa052150.47644490
123Alcoholism_Homo sapiens_hsa050340.47264708
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46522739
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45635701
126RNA polymerase_Homo sapiens_hsa030200.45130340

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