HEY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cGMP-mediated signaling (GO:0019934)5.42111930
2tonic smooth muscle contraction (GO:0014820)5.41443850
3positive regulation of vascular permeability (GO:0043117)4.94396563
4vascular smooth muscle contraction (GO:0014829)4.77287929
5positive regulation of cardiac muscle hypertrophy (GO:0010613)4.75211759
6positive regulation of muscle hypertrophy (GO:0014742)4.75211759
7artery smooth muscle contraction (GO:0014824)4.67519876
8regulation of cardiac muscle cell contraction (GO:0086004)4.65734127
9endocardial cushion morphogenesis (GO:0003203)4.62829832
10regulation of actin filament-based movement (GO:1903115)4.62119399
11cardiac myofibril assembly (GO:0055003)4.56605860
12* ventricular trabecula myocardium morphogenesis (GO:0003222)4.51594958
13positive regulation of cardiac muscle cell differentiation (GO:2000727)4.47302318
14endothelium development (GO:0003158)4.30444744
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.25525077
16negative regulation of potassium ion transmembrane transport (GO:1901380)4.12962077
17negative regulation of vascular permeability (GO:0043116)4.09611009
18muscle cell proliferation (GO:0033002)3.96148944
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.92510075
20* heart trabecula morphogenesis (GO:0061384)3.89173099
21* negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.86201800
22* positive regulation of cardiac muscle tissue growth (GO:0055023)3.83207180
23gap junction assembly (GO:0016264)3.81197234
24mesenchyme morphogenesis (GO:0072132)3.78885395
25cardiac muscle cell proliferation (GO:0060038)3.69782394
26positive regulation of endothelial cell apoptotic process (GO:2000353)3.69220355
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69047924
28lymph vessel development (GO:0001945)3.68823313
29regulation of the force of heart contraction (GO:0002026)3.66525684
30* positive regulation of cardiac muscle tissue development (GO:0055025)3.64285444
31myofibril assembly (GO:0030239)3.59210218
32glomerulus development (GO:0032835)3.54706405
33cell proliferation involved in metanephros development (GO:0072203)3.51372652
34regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.50178559
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.49746261
36cell communication by electrical coupling (GO:0010644)3.49427422
37* positive regulation of heart growth (GO:0060421)3.41301173
38regulation of sarcomere organization (GO:0060297)3.40433738
39atrial cardiac muscle cell action potential (GO:0086014)3.39438082
40positive regulation of systemic arterial blood pressure (GO:0003084)3.38501900
41* ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.38351773
42positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.35221851
43cardiac muscle contraction (GO:0060048)3.34661032
44positive regulation of catenin import into nucleus (GO:0035413)3.31583896
45adult heart development (GO:0007512)3.30800393
46atrioventricular valve morphogenesis (GO:0003181)3.27153709
47* heart trabecula formation (GO:0060347)3.24134739
48* mesenchymal cell development (GO:0014031)3.23434671
49* cardiac cell development (GO:0055006)3.22839103
50lymphangiogenesis (GO:0001946)3.22482399
51embryonic heart tube development (GO:0035050)3.19319021
52actin-mediated cell contraction (GO:0070252)3.19166348
53cardiac muscle tissue development (GO:0048738)3.18966046
54striated muscle cell proliferation (GO:0014855)3.18200169
55* cardiac muscle tissue morphogenesis (GO:0055008)3.17838560
56somite development (GO:0061053)3.17643884
57* negative regulation of striated muscle cell apoptotic process (GO:0010664)3.17427007
58regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17314017
59* cardiac muscle cell development (GO:0055013)3.17088385
60negative regulation of androgen receptor signaling pathway (GO:0060766)3.16970771
61* ventricular cardiac muscle cell development (GO:0055015)3.16966339
62actin-myosin filament sliding (GO:0033275)3.15600931
63muscle filament sliding (GO:0030049)3.15600931
64* smooth muscle cell differentiation (GO:0051145)3.15023423
65regulation of cardiac muscle cell differentiation (GO:2000725)3.11522815
66potassium ion import (GO:0010107)3.09853247
67regulation of heart morphogenesis (GO:2000826)3.07133375
68neural crest cell development (GO:0014032)3.06904647
69enteric nervous system development (GO:0048484)3.06417068
70negative regulation of telomerase activity (GO:0051974)3.05627820
71sarcomere organization (GO:0045214)3.05396765
72outflow tract septum morphogenesis (GO:0003148)3.05340023
73corticosteroid receptor signaling pathway (GO:0031958)3.02060280
74paraxial mesoderm development (GO:0048339)3.01607992
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01237135
76* muscle tissue morphogenesis (GO:0060415)3.00941301
77outer ear morphogenesis (GO:0042473)2.99481887
78cell morphogenesis involved in neuron differentiation (GO:0048667)2.98691218
79* cardiac muscle hypertrophy (GO:0003300)2.96712662
80* regulation of cardiac muscle tissue growth (GO:0055021)2.96396407
81regulation of relaxation of muscle (GO:1901077)2.94713483
82negative regulation of protein localization to cell surface (GO:2000009)2.94679040
83regulation of striated muscle contraction (GO:0006942)2.92829411
84* positive regulation of heart rate (GO:0010460)2.92579972
85radial glial cell differentiation (GO:0060019)2.92413376
86notochord development (GO:0030903)2.91960999
87regulation of cardiac muscle contraction (GO:0055117)2.90682984
88regulation of cardioblast differentiation (GO:0051890)2.90448221
89dermatan sulfate biosynthetic process (GO:0030208)2.90125286
90negative regulation of catenin import into nucleus (GO:0035414)2.88072002
91striated muscle contraction (GO:0006941)2.87134797
92regulation of cardiac muscle hypertrophy (GO:0010611)2.85946129
93cell proliferation involved in kidney development (GO:0072111)2.85745224
94cardiac muscle cell action potential (GO:0086001)2.85502726
95central nervous system myelination (GO:0022010)2.84730453
96axon ensheathment in central nervous system (GO:0032291)2.84730453
97positive regulation of neurotransmitter secretion (GO:0001956)2.84031153
98regulation of helicase activity (GO:0051095)2.83951431
99* cardiac right ventricle morphogenesis (GO:0003215)2.83093764
100* stem cell development (GO:0048864)2.83036898
101positive regulation of uterine smooth muscle contraction (GO:0070474)2.82323366
102DNA damage response, detection of DNA damage (GO:0042769)2.81199952
103epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.80862735
104* striated muscle hypertrophy (GO:0014897)2.78091667
105regulation of somitogenesis (GO:0014807)2.77495772
106regulation of membrane repolarization (GO:0060306)2.77381578
107ventricular septum development (GO:0003281)2.77127587
108negative regulation of multicellular organism growth (GO:0040015)2.77078838
109DNA replication checkpoint (GO:0000076)2.76135074
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.74298317
111* trabecula morphogenesis (GO:0061383)2.74047602
112regulation of muscle hypertrophy (GO:0014743)2.74032378
113ventricular cardiac muscle cell action potential (GO:0086005)2.71715377
114* heart valve formation (GO:0003188)2.71374496
115cell communication involved in cardiac conduction (GO:0086065)2.71195342
116* trabecula formation (GO:0060343)2.70591522
117adrenergic receptor signaling pathway (GO:0071875)2.69510982
118* positive regulation of muscle tissue development (GO:1901863)2.69183010
119* atrial septum morphogenesis (GO:0060413)2.69047417
120cardiac septum development (GO:0003279)2.68454440
121kidney mesenchyme development (GO:0072074)2.67400812
122* positive regulation of striated muscle tissue development (GO:0045844)2.66077216
123* positive regulation of muscle organ development (GO:0048636)2.66077216
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65364139
125cellular sodium ion homeostasis (GO:0006883)2.64787212
126* ventricular septum morphogenesis (GO:0060412)2.64717596
127* regulation of cardiac muscle tissue development (GO:0055024)2.64195039
128* positive regulation of heart contraction (GO:0045823)2.64155802
129* positive regulation of cardiac muscle cell proliferation (GO:0060045)2.63805630
130* Notch signaling involved in heart development (GO:0061314)2.60412003
131* aorta morphogenesis (GO:0035909)2.55697603
132sulfation (GO:0051923)2.53338619
133cardiac chamber formation (GO:0003207)2.51885111
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51743949
135dermatan sulfate metabolic process (GO:0030205)2.49362615
136somatic hypermutation of immunoglobulin genes (GO:0016446)2.48057028
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48057028
138metanephric mesenchyme development (GO:0072075)2.47759692
139cochlea morphogenesis (GO:0090103)2.47161044
140anterior/posterior axis specification, embryo (GO:0008595)2.45604863
141* regulation of striated muscle cell apoptotic process (GO:0010662)2.45588565
142otic vesicle formation (GO:0030916)2.42247873
143bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42245698
144presynaptic membrane assembly (GO:0097105)2.41428514
145regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.38739847
146regulation of cardioblast proliferation (GO:0003264)2.37725898
147regulation of secondary heart field cardioblast proliferation (GO:0003266)2.37725898
148cardiac ventricle formation (GO:0003211)2.37038438
149actomyosin structure organization (GO:0031032)2.36804157
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.36619018
151regulation of catenin import into nucleus (GO:0035412)2.36073238
152positive regulation of SMAD protein import into nucleus (GO:0060391)2.35853598
153regulation of SMAD protein import into nucleus (GO:0060390)2.35680602
154negative regulation of DNA biosynthetic process (GO:2000279)2.34061301
155* cardiac muscle hypertrophy in response to stress (GO:0014898)2.32503548
156* muscle hypertrophy in response to stress (GO:0003299)2.32503548
157* cardiac muscle adaptation (GO:0014887)2.32503548
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.32469389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.40100019
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05224822
3* EED_16625203_ChIP-ChIP_MESCs_Mouse2.77125910
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.76835192
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.75577238
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67443965
7EZH2_22144423_ChIP-Seq_EOC_Human2.66537677
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64851355
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61718882
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.59952693
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57849977
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57849977
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57849977
14E2F7_22180533_ChIP-Seq_HELA_Human2.55922586
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51189761
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51189761
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49898865
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46975606
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34348394
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32209878
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26698820
22GBX2_23144817_ChIP-Seq_PC3_Human2.24864948
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18468884
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14416305
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.13547324
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05135155
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96024183
28* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89918980
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89453669
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87386948
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.86532089
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.84439956
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.80980452
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79899121
35IGF1R_20145208_ChIP-Seq_DFB_Human1.79214606
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77800394
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.73721494
38FUS_26573619_Chip-Seq_HEK293_Human1.73323518
39BCAT_22108803_ChIP-Seq_LS180_Human1.70954804
40TAF15_26573619_Chip-Seq_HEK293_Human1.70866412
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70694587
42AR_21572438_ChIP-Seq_LNCaP_Human1.70152712
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.69261531
44EWS_26573619_Chip-Seq_HEK293_Human1.68251252
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67577852
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63809668
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.63623058
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62454758
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60361141
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59924346
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.59771783
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58410514
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57334784
54VDR_22108803_ChIP-Seq_LS180_Human1.54412903
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54361459
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53423129
57TP53_16413492_ChIP-PET_HCT116_Human1.53333441
58* ISL1_27105846_Chip-Seq_CPCs_Mouse1.52382451
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44786467
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43656221
61RNF2_27304074_Chip-Seq_NSC_Mouse1.42446649
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42068430
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41765933
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.41303380
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.40753384
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39826795
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37410021
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36753985
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35323485
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33445100
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32691896
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.32555871
73* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32403105
74SMAD4_21799915_ChIP-Seq_A2780_Human1.32343732
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31121047
76* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30959452
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30199335
78* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29325608
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27691048
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27271011
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27188388
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.26809108
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.26809108
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26065562
85P300_19829295_ChIP-Seq_ESCs_Human1.25695079
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.24684060
87TP53_18474530_ChIP-ChIP_U2OS_Human1.24457719
88CJUN_26792858_Chip-Seq_BT549_Human1.24441803
89* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24394992
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23410923
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23271090
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23215439
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.21889797
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21235431
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19756913
96* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19359262
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19288585
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19288585
99DROSHA_22980978_ChIP-Seq_HELA_Human1.18382017
100* TP53_20018659_ChIP-ChIP_R1E_Mouse1.17523163
101* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16683429
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16409760
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16314897
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15651751
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14331867
106* SOX9_26525672_Chip-Seq_HEART_Mouse1.14121412
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14047919
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13082005
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12801620
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11065605
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10822129
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.10749293
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10032201
114* AR_19668381_ChIP-Seq_PC3_Human1.09659741
115* AHR_22903824_ChIP-Seq_MCF-7_Human1.08759855
116* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08054243
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07837110
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07589314
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07167771
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06159605
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05778720
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05478859
123PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05342530
124* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05068245
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04881426
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.04185153
127RUNX2_22187159_ChIP-Seq_PCA_Human1.03278806
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02676957
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02617735
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02599795
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02510432
132ZNF274_21170338_ChIP-Seq_K562_Hela1.02312928
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.99654108
134* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99435388
135* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99179968
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.98966964
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97566430
138LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97444776
139* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97246545
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96905615
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96543797
142* STAT3_23295773_ChIP-Seq_U87_Human0.95184455
143* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95109354
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.95106523
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94888298
146CLOCK_20551151_ChIP-Seq_293T_Human0.94828776
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94689544
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93218800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.08962350
2MP0004215_abnormal_myocardial_fiber3.57546314
3MP0004084_abnormal_cardiac_muscle3.43193948
4MP0010368_abnormal_lymphatic_system3.37174936
5MP0005623_abnormal_meninges_morphology3.17578288
6MP0002009_preneoplasia2.86880792
7MP0003279_aneurysm2.81668759
8MP0004036_abnormal_muscle_relaxation2.74248434
9MP0000751_myopathy2.70341797
10* MP0002972_abnormal_cardiac_muscle2.40223096
11* MP0002127_abnormal_cardiovascular_syste2.14084475
12MP0003828_pulmonary_edema2.14049009
13* MP0009384_cardiac_valve_regurgitation2.13556722
14MP0003950_abnormal_plasma_membrane2.11469324
15MP0008775_abnormal_heart_ventricle2.10696580
16* MP0005620_abnormal_muscle_contractility2.04493978
17* MP0005330_cardiomyopathy2.03775637
18MP0005167_abnormal_blood-brain_barrier2.02288620
19MP0005367_renal/urinary_system_phenotyp1.97862954
20MP0000516_abnormal_urinary_system1.97862954
21MP0001879_abnormal_lymphatic_vessel1.95935930
22MP0003137_abnormal_impulse_conducting1.95859828
23MP0005377_hearing/vestibular/ear_phenot1.94403279
24MP0003878_abnormal_ear_physiology1.94403279
25MP0000749_muscle_degeneration1.92235909
26* MP0004085_abnormal_heartbeat1.89154163
27* MP0010630_abnormal_cardiac_muscle1.83552961
28MP0002837_dystrophic_cardiac_calcinosis1.81902730
29MP0003122_maternal_imprinting1.79669754
30MP0002938_white_spotting1.75806583
31MP0000767_abnormal_smooth_muscle1.72309837
32MP0004145_abnormal_muscle_electrophysio1.71008216
33MP0003646_muscle_fatigue1.63261492
34* MP0001544_abnormal_cardiovascular_syste1.61727880
35* MP0005385_cardiovascular_system_phenoty1.61727880
36MP0000537_abnormal_urethra_morphology1.60433485
37MP0001299_abnormal_eye_distance/1.60336417
38MP0004133_heterotaxia1.60296263
39* MP0006138_congestive_heart_failure1.59731619
40MP0003941_abnormal_skin_development1.52131118
41MP0001346_abnormal_lacrimal_gland1.48157824
42MP0003119_abnormal_digestive_system1.44200719
43MP0004484_altered_response_of1.42998476
44MP0005423_abnormal_somatic_nervous1.42134194
45MP0002295_abnormal_pulmonary_circulatio1.41277183
46MP0002282_abnormal_trachea_morphology1.38632207
47MP0005503_abnormal_tendon_morphology1.38580536
48MP0008058_abnormal_DNA_repair1.38157020
49MP0008932_abnormal_embryonic_tissue1.37435461
50MP0004233_abnormal_muscle_weight1.33471887
51MP0010030_abnormal_orbit_morphology1.33006741
52* MP0004087_abnormal_muscle_fiber1.31859995
53MP0003693_abnormal_embryo_hatching1.31326217
54MP0002877_abnormal_melanocyte_morpholog1.30607376
55MP0002697_abnormal_eye_size1.30552454
56MP0003937_abnormal_limbs/digits/tail_de1.29157813
57MP0002108_abnormal_muscle_morphology1.29018925
58MP0009250_abnormal_appendicular_skeleto1.28308502
59MP0005187_abnormal_penis_morphology1.27560921
60MP0005595_abnormal_vascular_smooth1.25691520
61MP0000049_abnormal_middle_ear1.20592503
62MP0003385_abnormal_body_wall1.18448835
63MP0009053_abnormal_anal_canal1.16267880
64MP0000372_irregular_coat_pigmentation1.15580968
65MP0005171_absent_coat_pigmentation1.13881803
66MP0001485_abnormal_pinna_reflex1.13811464
67MP0005165_increased_susceptibility_to1.13076668
68MP0005369_muscle_phenotype1.12503807
69MP0003283_abnormal_digestive_organ1.10541914
70MP0000534_abnormal_ureter_morphology1.08317030
71MP0003890_abnormal_embryonic-extraembry1.08233433
72MP0003136_yellow_coat_color1.07410824
73MP0002249_abnormal_larynx_morphology1.07231913
74MP0006054_spinal_hemorrhage1.07227278
75MP0003567_abnormal_fetal_cardiomyocyte1.06859628
76MP0002106_abnormal_muscle_physiology1.05580697
77MP0009672_abnormal_birth_weight1.04317945
78MP0000428_abnormal_craniofacial_morphol1.03192768
79MP0000750_abnormal_muscle_regeneration1.03088990
80* MP0002925_abnormal_cardiovascular_devel1.02869588
81MP0003121_genomic_imprinting1.02174857
82MP0004885_abnormal_endolymph1.02067508
83MP0003755_abnormal_palate_morphology1.01074670
84MP0001968_abnormal_touch/_nociception1.00347389
85MP0001270_distended_abdomen1.00190857
86MP0002085_abnormal_embryonic_tissue0.99584413
87MP0004957_abnormal_blastocyst_morpholog0.98150387
88MP0001286_abnormal_eye_development0.98123758
89MP0002128_abnormal_blood_circulation0.97875649
90MP0010094_abnormal_chromosome_stability0.95374846
91MP0005084_abnormal_gallbladder_morpholo0.95345614
92MP0010386_abnormal_urinary_bladder0.95162367
93MP0003942_abnormal_urinary_system0.93265968
94MP0001293_anophthalmia0.91485989
95* MP0000266_abnormal_heart_morphology0.89458050
96MP0003935_abnormal_craniofacial_develop0.88054537
97MP0002751_abnormal_autonomic_nervous0.87687158
98MP0002269_muscular_atrophy0.87620200
99MP0003718_maternal_effect0.86869469
100MP0002254_reproductive_system_inflammat0.86159038
101MP0000230_abnormal_systemic_arterial0.85986607
102MP0005409_darkened_coat_color0.85377480
103MP0003300_gastrointestinal_ulcer0.85312025
104MP0000747_muscle_weakness0.83674527
105MP0005380_embryogenesis_phenotype0.83244402
106MP0001672_abnormal_embryogenesis/_devel0.83244402
107MP0000759_abnormal_skeletal_muscle0.83238762
108MP0002233_abnormal_nose_morphology0.82839861
109MP0002332_abnormal_exercise_endurance0.82508245
110* MP0001614_abnormal_blood_vessel0.81909452
111MP0000778_abnormal_nervous_system0.81767676
112MP0003861_abnormal_nervous_system0.81161730
113MP0000163_abnormal_cartilage_morphology0.80572496
114MP0002084_abnormal_developmental_patter0.79141674
115MP0006072_abnormal_retinal_apoptosis0.78964229
116MP0003984_embryonic_growth_retardation0.78501310
117MP0000566_synostosis0.77133641
118MP0003077_abnormal_cell_cycle0.76683917
119MP0000462_abnormal_digestive_system0.76418252
120MP0001486_abnormal_startle_reflex0.76106748
121MP0002088_abnormal_embryonic_growth/wei0.75804356
122MP0003705_abnormal_hypodermis_morpholog0.75742396
123MP0003880_abnormal_central_pattern0.75120246
124MP0003787_abnormal_imprinting0.75104508
125MP0002234_abnormal_pharynx_morphology0.74873363
126MP0002111_abnormal_tail_morphology0.74612898
127MP0001784_abnormal_fluid_regulation0.74158428
128MP0000762_abnormal_tongue_morphology0.73654136
129MP0009780_abnormal_chondrocyte_physiolo0.73378089
130MP0002133_abnormal_respiratory_system0.69776938
131MP0005388_respiratory_system_phenotype0.69776938
132MP0005508_abnormal_skeleton_morphology0.69248860
133MP0001661_extended_life_span0.68746862
134MP0002116_abnormal_craniofacial_bone0.68587696
135MP0006276_abnormal_autonomic_nervous0.65970671
136MP0002736_abnormal_nociception_after0.65523085
137MP0002089_abnormal_postnatal_growth/wei0.65473356
138MP0005253_abnormal_eye_physiology0.64205612
139MP0000026_abnormal_inner_ear0.62898163

Predicted human phenotypes

RankGene SetZ-score
1Subaortic stenosis (HP:0001682)6.04295410
2Abnormality of the left ventricular outflow tract (HP:0011103)6.04295410
3Sudden death (HP:0001699)4.31503325
4Calf muscle hypertrophy (HP:0008981)4.18552607
5Abnormality of the calf musculature (HP:0001430)4.03533146
6Abnormality of the parietal bone (HP:0002696)3.84010040
7Muscle hypertrophy of the lower extremities (HP:0008968)3.77068788
8Short 4th metacarpal (HP:0010044)3.55516255
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.55516255
10Midline defect of the nose (HP:0004122)3.41065786
11Hypoplastic left heart (HP:0004383)3.30559664
12Aortic aneurysm (HP:0004942)3.26085331
13Pulmonary artery stenosis (HP:0004415)3.19217376
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.17753939
15Atrial fibrillation (HP:0005110)3.12678653
16Trigonocephaly (HP:0000243)3.03084314
17Ventricular tachycardia (HP:0004756)3.00239898
18Short hallux (HP:0010109)3.00014478
19Hemiparesis (HP:0001269)2.95894157
20Primary atrial arrhythmia (HP:0001692)2.94445922
21Lipoatrophy (HP:0100578)2.93896925
22Mesangial abnormality (HP:0001966)2.93154627
23Esophageal atresia (HP:0002032)2.92253833
24Syncope (HP:0001279)2.92104012
25Supraventricular arrhythmia (HP:0005115)2.91335312
26Supraventricular tachycardia (HP:0004755)2.81616329
27Prolonged QT interval (HP:0001657)2.79485281
28Aplasia/Hypoplasia of the hallux (HP:0008362)2.78625737
29Synostosis involving the elbow (HP:0003938)2.78074622
30Humeroradial synostosis (HP:0003041)2.78074622
31Bone cyst (HP:0012062)2.76156251
32Ventricular arrhythmia (HP:0004308)2.76110970
33Broad metatarsal (HP:0001783)2.70403444
34Exercise-induced muscle cramps (HP:0003710)2.67978198
35Median cleft lip (HP:0000161)2.66776826
36Nemaline bodies (HP:0003798)2.66709952
37Muscle fiber inclusion bodies (HP:0100299)2.63828142
38Septo-optic dysplasia (HP:0100842)2.63310795
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62169201
40Abnormality of the 4th metacarpal (HP:0010012)2.61872986
41Aortic dissection (HP:0002647)2.60235963
42Aplasia involving bones of the extremities (HP:0009825)2.59751760
43Aplasia involving bones of the upper limbs (HP:0009823)2.59751760
44Aplasia of the phalanges of the hand (HP:0009802)2.59751760
45Maternal diabetes (HP:0009800)2.58049343
46Hypoplastic ischia (HP:0003175)2.57418601
47Abnormal ventriculo-arterial connection (HP:0011563)2.56345730
48Transposition of the great arteries (HP:0001669)2.56345730
49Abnormal connection of the cardiac segments (HP:0011545)2.56345730
50Preauricular pit (HP:0004467)2.54334876
51Periauricular skin pits (HP:0100277)2.54334876
52Colon cancer (HP:0003003)2.47198363
53Neoplasm of the heart (HP:0100544)2.46598458
54Adactyly (HP:0009776)2.45497471
55Mesomelia (HP:0003027)2.43449183
56Abnormality of the ischium (HP:0003174)2.42241392
57Hypoplastic heart (HP:0001961)2.42211447
58Double outlet right ventricle (HP:0001719)2.40729497
59Congenital malformation of the right heart (HP:0011723)2.40729497
60Abnormality of the aortic arch (HP:0012303)2.39962226
61Hemiplegia (HP:0002301)2.39591545
62Chorioretinal atrophy (HP:0000533)2.39299001
63Potter facies (HP:0002009)2.36202040
64Facial shape deformation (HP:0011334)2.36202040
65Gastrointestinal atresia (HP:0002589)2.33667312
66EMG: myopathic abnormalities (HP:0003458)2.29067769
67Areflexia of lower limbs (HP:0002522)2.28430810
68Abnormal atrioventricular conduction (HP:0005150)2.27707774
69Recurrent corneal erosions (HP:0000495)2.27090499
70Skull defect (HP:0001362)2.19457045
71Aplasia cutis congenita (HP:0001057)2.17501751
72Skin pits (HP:0100276)2.14239993
73Dilated cardiomyopathy (HP:0001644)2.12906800
74Depressed nasal tip (HP:0000437)2.11616801
75Vitreoretinal degeneration (HP:0000655)2.09243884
76Ventricular fibrillation (HP:0001663)2.08413282
77Right ventricular cardiomyopathy (HP:0011663)2.04429588
78Atrioventricular block (HP:0001678)2.03466592
79Increased serum pyruvate (HP:0003542)2.02677720
80Alacrima (HP:0000522)1.99485591
81Medulloblastoma (HP:0002885)1.99414085
82Birth length less than 3rd percentile (HP:0003561)1.99245666
83Anophthalmia (HP:0000528)1.97512762
84Bilateral microphthalmos (HP:0007633)1.96357258
85Rimmed vacuoles (HP:0003805)1.94776643
86Preaxial foot polydactyly (HP:0001841)1.92081558
87Scapular winging (HP:0003691)1.90948250
88Hypoplasia of the iris (HP:0007676)1.90619945
89Hypoplastic pelvis (HP:0008839)1.90319459
90Intestinal polyposis (HP:0200008)1.89332542
91Hyporeflexia of lower limbs (HP:0002600)1.88977590
92Absent phalangeal crease (HP:0006109)1.88858146
93Shallow orbits (HP:0000586)1.88748907
94Exostoses (HP:0100777)1.88089353
95Abnormality of glycolysis (HP:0004366)1.87051503
96Atonic seizures (HP:0010819)1.83887756
97Occipital encephalocele (HP:0002085)1.82845486
98Intestinal polyp (HP:0005266)1.82816840
99Choanal stenosis (HP:0000452)1.82778543
100Ependymoma (HP:0002888)1.81906917
101Abnormality of the nasal septum (HP:0000419)1.81238699
102Vertebral arch anomaly (HP:0008438)1.80847649
103Broad ribs (HP:0000885)1.79948087
104Metaphyseal dysplasia (HP:0100255)1.79384052
105Cutaneous finger syndactyly (HP:0010554)1.78586511
106Left ventricular hypertrophy (HP:0001712)1.78257506
107Asymmetry of the thorax (HP:0001555)1.78011825
108Venous insufficiency (HP:0005293)1.77525087
109Spastic diplegia (HP:0001264)1.77089988
110Benign neoplasm of the central nervous system (HP:0100835)1.76996174
111Hydroureter (HP:0000072)1.76104055
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.74881986
113Bell-shaped thorax (HP:0001591)1.74837501
114Abnormality of the pubic bones (HP:0003172)1.74774479
115Absent toe (HP:0010760)1.74332707
116Calcaneovalgus deformity (HP:0001848)1.73890137
117Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.72862388
118Diaphragmatic weakness (HP:0009113)1.72656928
119Type 1 muscle fiber predominance (HP:0003803)1.72119450
120Coarctation of aorta (HP:0001680)1.72052990
121EMG: neuropathic changes (HP:0003445)1.71957198
122Cutaneous syndactyly (HP:0012725)1.71146959
123Abnormal lung lobation (HP:0002101)1.69059953
124Renal hypoplasia (HP:0000089)1.68912780
125Sprengel anomaly (HP:0000912)1.68618189
126Heart block (HP:0012722)1.68222644
127Myotonia (HP:0002486)1.68072562
128Lymphangioma (HP:0100764)1.67819537
129Childhood onset (HP:0011463)1.67423265
130Nasolacrimal duct obstruction (HP:0000579)1.67088935
131Bicuspid aortic valve (HP:0001647)1.66751860
132Abnormality of the fetal cardiovascular system (HP:0010948)1.66369614
133Abnormal umbilical cord blood vessels (HP:0011403)1.66369614
134Single umbilical artery (HP:0001195)1.66369614
135Abnormal EKG (HP:0003115)1.65315959
136Glioma (HP:0009733)1.64468101
137Hip contracture (HP:0003273)1.64146102
138Scotoma (HP:0000575)1.63397721
139Neoplasm of the oral cavity (HP:0100649)1.62969202
140Hyperglycinuria (HP:0003108)1.62744678
141Abnormality of the diencephalon (HP:0010662)1.61415944
142Bundle branch block (HP:0011710)1.61093924
143Absent septum pellucidum (HP:0001331)1.61036862
144Distal arthrogryposis (HP:0005684)1.60867960
145Supernumerary ribs (HP:0005815)1.60579240
146Intestinal atresia (HP:0011100)1.58694940
147Bifid tongue (HP:0010297)1.58670195
148Astrocytoma (HP:0009592)1.58218784
149Abnormality of the astrocytes (HP:0100707)1.58218784
150Steppage gait (HP:0003376)1.56947545
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56927157
152Muscle fiber splitting (HP:0003555)1.56854320
153Ectopic anus (HP:0004397)1.56226283
154Vascular tortuosity (HP:0004948)1.56055102
155Anencephaly (HP:0002323)1.55974121
156Abnormal number of incisors (HP:0011064)1.55480481
157Abnormality of the shoulder girdle musculature (HP:0001435)1.55049322
158Meckel diverticulum (HP:0002245)1.53997763
159Broad toe (HP:0001837)1.53608698
160Nephroblastoma (Wilms tumor) (HP:0002667)1.51919728
161Abnormality of chromosome segregation (HP:0002916)1.50933440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK7.28305455
2PNCK4.39428663
3DMPK3.56132844
4TSSK63.53093627
5ZAK3.21932015
6TAF13.16540668
7VRK23.07401556
8WEE12.87253296
9DDR22.77953540
10STK38L2.77697921
11NUAK12.64992008
12PAK22.59158068
13STK242.42244222
14TAOK22.40856708
15CDC72.35920959
16MKNK22.33481152
17TIE12.20550087
18CDC42BPA2.14242646
19VRK11.96093728
20TNIK1.96025459
21PDGFRA1.87464101
22PKN21.81777858
23PAK31.81587363
24OBSCN1.80665694
25LMTK21.76477361
26WNK31.73253545
27STK391.70320705
28LATS11.70183915
29BUB11.63443699
30PLK31.61243638
31NME11.56952570
32ROCK11.54622499
33PBK1.49112481
34MST41.46383837
35ILK1.44411423
36TTK1.42115731
37MARK21.40912843
38MKNK11.40742623
39MAP3K101.37771107
40PTK2B1.36206707
41PIK3CA1.33246679
42AKT31.33131345
43PRKD11.32673105
44MUSK1.32460865
45PLK41.31364022
46WNK41.30867123
47PHKG11.28439721
48PHKG21.28439721
49NTRK21.26766981
50DAPK31.22452050
51KDR1.19871454
52EPHB21.17396790
53DYRK21.13634477
54ICK1.13244125
55STK381.12206180
56LATS21.11789560
57STK41.04361078
58PRKCE1.02838586
59EPHB11.00881731
60RAF10.99520189
61PDK20.94240495
62RET0.93895728
63NTRK10.93359729
64CASK0.89308425
65UHMK10.87880945
66CDK60.87470282
67MAP3K120.86907209
68PKN10.85809647
69MAPK120.83288416
70BRSK10.81283096
71TLK10.80962419
72FGFR10.76413573
73PRKD30.76056023
74STK160.75949159
75RIPK10.74951603
76OXSR10.73630029
77WNK10.72967032
78CDK90.71647239
79CDK30.69437601
80TRIB30.69399753
81SMG10.68980995
82YES10.68645667
83ROCK20.68574346
84CSNK1G10.68168234
85MINK10.67606177
86INSRR0.66482400
87IGF1R0.65539465
88MAPK70.65228939
89MELK0.64577061
90TRPM70.63719391
91PRKCQ0.63337255
92PLK10.63205632
93CAMK10.63059953
94PDGFRB0.62621863
95TTN0.62277704
96MET0.61908383
97PRKAA20.61279301
98CAMK2D0.61141267
99MAPKAPK30.61131826
100PTK20.60856269
101BRSK20.59418615
102PRKACB0.59209615
103CAMK2A0.58631860
104FGFR20.58228781
105MAP2K40.56787642
106EPHA40.55116116
107PRKCG0.55099138
108CHEK20.53363373
109EIF2AK30.53338315
110PAK60.52716625
111BMPR1B0.52715526
112MAP3K50.51157743
113LIMK10.50933833
114KSR20.48811314
115ABL20.48222516
116ADRBK10.47968771
117AURKB0.47144100
118FGR0.46780397
119PRKACA0.46170959
120EEF2K0.46011786
121AKT20.45974197
122GSK3A0.44180139
123CSNK1G20.44097008
124GRK10.42424192
125CDK50.42402624
126STK110.41913081
127MAP3K20.41575118
128MAP3K90.41124343
129PRKCH0.40858508
130ERBB40.40438059
131PRKG10.40280015
132CAMK1G0.40036316
133CDK140.39927836
134AURKA0.39208371
135CDK150.38465333
136BMX0.37600289
137PINK10.37370490
138MAPKAPK50.37340933
139PLK20.37320471
140NLK0.37211739
141MAPK150.37140716
142NEK90.36609880
143CSNK1G30.35708238
144DYRK1A0.35400437
145FER0.34767859
146CDK180.34633005
147RPS6KA10.33744881
148PRKAA10.33607351
149TGFBR10.33437281
150CDK70.33263478
151NTRK30.33010229
152PRKDC0.32887774
153NEK10.32767461
154MAPK40.32403830
155SRC0.31865594
156ATR0.31612003
157SGK10.30380988
158INSR0.30183459
159CSNK1E0.29648411
160MAP2K60.29119027
161CAMK2G0.28772648

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.65515659
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.15099867
3Cardiac muscle contraction_Homo sapiens_hsa042603.04934747
4Renin secretion_Homo sapiens_hsa049242.81710623
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68425977
6cGMP-PKG signaling pathway_Homo sapiens_hsa040222.17794226
7Vascular smooth muscle contraction_Homo sapiens_hsa042702.09174584
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91166029
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84035221
10Basal cell carcinoma_Homo sapiens_hsa052171.77960148
11Focal adhesion_Homo sapiens_hsa045101.77630460
12Sulfur relay system_Homo sapiens_hsa041221.76823312
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.72220809
14cAMP signaling pathway_Homo sapiens_hsa040241.69267553
15ECM-receptor interaction_Homo sapiens_hsa045121.68606417
16Adherens junction_Homo sapiens_hsa045201.62234058
17Mismatch repair_Homo sapiens_hsa034301.60469804
18RNA polymerase_Homo sapiens_hsa030201.59714487
19Gap junction_Homo sapiens_hsa045401.49487750
20Basal transcription factors_Homo sapiens_hsa030221.48835978
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47080867
22Hedgehog signaling pathway_Homo sapiens_hsa043401.45864380
23Ribosome_Homo sapiens_hsa030101.45609341
24Oxytocin signaling pathway_Homo sapiens_hsa049211.43758590
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43729326
26Dorso-ventral axis formation_Homo sapiens_hsa043201.42844701
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40741347
28DNA replication_Homo sapiens_hsa030301.38283447
29Calcium signaling pathway_Homo sapiens_hsa040201.37439154
30Parkinsons disease_Homo sapiens_hsa050121.37015152
31Circadian entrainment_Homo sapiens_hsa047131.36722264
32Pyruvate metabolism_Homo sapiens_hsa006201.36661761
33TGF-beta signaling pathway_Homo sapiens_hsa043501.36190847
34Salivary secretion_Homo sapiens_hsa049701.36155320
35Fanconi anemia pathway_Homo sapiens_hsa034601.32890750
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29104577
37GABAergic synapse_Homo sapiens_hsa047271.29011932
38Morphine addiction_Homo sapiens_hsa050321.28200233
39One carbon pool by folate_Homo sapiens_hsa006701.27536787
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27522051
41Glutamatergic synapse_Homo sapiens_hsa047241.26280762
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26277004
43Oxidative phosphorylation_Homo sapiens_hsa001901.24695163
44Tight junction_Homo sapiens_hsa045301.24385245
45Notch signaling pathway_Homo sapiens_hsa043301.23305115
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19319066
47Alzheimers disease_Homo sapiens_hsa050101.18175337
48Fatty acid biosynthesis_Homo sapiens_hsa000611.16160826
49Proteoglycans in cancer_Homo sapiens_hsa052051.15113009
50Insulin secretion_Homo sapiens_hsa049111.13425346
51Spliceosome_Homo sapiens_hsa030401.13022782
52Fatty acid metabolism_Homo sapiens_hsa012121.11491437
53Viral myocarditis_Homo sapiens_hsa054161.11154162
54Melanogenesis_Homo sapiens_hsa049161.11090094
55Arginine and proline metabolism_Homo sapiens_hsa003301.09804334
56Hippo signaling pathway_Homo sapiens_hsa043901.08839146
57Gastric acid secretion_Homo sapiens_hsa049711.06377565
58Wnt signaling pathway_Homo sapiens_hsa043101.04425929
59Axon guidance_Homo sapiens_hsa043601.04367208
60Serotonergic synapse_Homo sapiens_hsa047261.04097597
61Non-homologous end-joining_Homo sapiens_hsa034501.03083807
62Melanoma_Homo sapiens_hsa052181.03037717
63Nitrogen metabolism_Homo sapiens_hsa009101.01460618
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00515618
65Fatty acid degradation_Homo sapiens_hsa000710.99717977
66Folate biosynthesis_Homo sapiens_hsa007900.99534436
67Bile secretion_Homo sapiens_hsa049760.99517111
68Cholinergic synapse_Homo sapiens_hsa047250.99016496
69Homologous recombination_Homo sapiens_hsa034400.98474724
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97747375
71Rap1 signaling pathway_Homo sapiens_hsa040150.97088536
72Base excision repair_Homo sapiens_hsa034100.96817272
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96517736
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95800196
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93610970
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.92773253
77Steroid biosynthesis_Homo sapiens_hsa001000.92510116
78Cell cycle_Homo sapiens_hsa041100.92280235
79Amoebiasis_Homo sapiens_hsa051460.92112920
80Huntingtons disease_Homo sapiens_hsa050160.91479326
81Propanoate metabolism_Homo sapiens_hsa006400.91434337
82beta-Alanine metabolism_Homo sapiens_hsa004100.89359744
83RNA degradation_Homo sapiens_hsa030180.87588063
84Phenylalanine metabolism_Homo sapiens_hsa003600.87380465
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86986025
86Pathways in cancer_Homo sapiens_hsa052000.83105382
87Ras signaling pathway_Homo sapiens_hsa040140.82472132
88mRNA surveillance pathway_Homo sapiens_hsa030150.82445398
89Estrogen signaling pathway_Homo sapiens_hsa049150.82281171
90RNA transport_Homo sapiens_hsa030130.80697929
91Ovarian steroidogenesis_Homo sapiens_hsa049130.80519385
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78913241
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77927494
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77836955
95Selenocompound metabolism_Homo sapiens_hsa004500.77692363
96Renal cell carcinoma_Homo sapiens_hsa052110.77212787
97Purine metabolism_Homo sapiens_hsa002300.75468202
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74914878
99Dopaminergic synapse_Homo sapiens_hsa047280.74582844
100Biosynthesis of amino acids_Homo sapiens_hsa012300.72958600
101Amphetamine addiction_Homo sapiens_hsa050310.72179482
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71939102
103Histidine metabolism_Homo sapiens_hsa003400.71024458
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70172598
105Platelet activation_Homo sapiens_hsa046110.69223067
106Circadian rhythm_Homo sapiens_hsa047100.68885835
107Small cell lung cancer_Homo sapiens_hsa052220.68253583
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68083367
109Nucleotide excision repair_Homo sapiens_hsa034200.66266208
110Tyrosine metabolism_Homo sapiens_hsa003500.65661306
111Glucagon signaling pathway_Homo sapiens_hsa049220.65657156
112Protein digestion and absorption_Homo sapiens_hsa049740.65535282
113Oocyte meiosis_Homo sapiens_hsa041140.65345805
114Cocaine addiction_Homo sapiens_hsa050300.64454656
115Carbon metabolism_Homo sapiens_hsa012000.64235128
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.63523734
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62468068
118Long-term depression_Homo sapiens_hsa047300.62467605
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61715575
120Pancreatic secretion_Homo sapiens_hsa049720.61475270
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.61327767
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60601934
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60585060
124Proteasome_Homo sapiens_hsa030500.60207709
125Long-term potentiation_Homo sapiens_hsa047200.59250249
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58237412
127Taste transduction_Homo sapiens_hsa047420.58138110
128PPAR signaling pathway_Homo sapiens_hsa033200.56717161
129Insulin resistance_Homo sapiens_hsa049310.55937498
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55557975
131MicroRNAs in cancer_Homo sapiens_hsa052060.53450805
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.51358246
133GnRH signaling pathway_Homo sapiens_hsa049120.51252237
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50987581
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50962984
136Nicotine addiction_Homo sapiens_hsa050330.50568939
137Glioma_Homo sapiens_hsa052140.49517674
138Olfactory transduction_Homo sapiens_hsa047400.49398665
139MAPK signaling pathway_Homo sapiens_hsa040100.49221038
140HIF-1 signaling pathway_Homo sapiens_hsa040660.49070679
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48086685
142Vitamin digestion and absorption_Homo sapiens_hsa049770.47810812
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47180211
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46055282
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45934068
146Type II diabetes mellitus_Homo sapiens_hsa049300.44621828
147Fatty acid elongation_Homo sapiens_hsa000620.44620851
148Thyroid hormone synthesis_Homo sapiens_hsa049180.43461533
149Prostate cancer_Homo sapiens_hsa052150.41778617

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