HFE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)6.45266111
2response to muscle activity (GO:0014850)6.30555979
3actin-myosin filament sliding (GO:0033275)6.08319622
4muscle filament sliding (GO:0030049)6.08319622
5regulation of skeletal muscle contraction (GO:0014819)5.86538091
6skeletal muscle fiber development (GO:0048741)5.64091917
7NADH metabolic process (GO:0006734)5.27815032
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.20345358
9L-phenylalanine catabolic process (GO:0006559)5.20345358
10response to inactivity (GO:0014854)5.18441675
11carnitine shuttle (GO:0006853)5.17492038
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.11058913
13L-phenylalanine metabolic process (GO:0006558)5.11058913
14myotube cell development (GO:0014904)5.10634824
15fatty acid transmembrane transport (GO:1902001)5.02251211
16actin-mediated cell contraction (GO:0070252)4.96806448
17muscle contraction (GO:0006936)4.84791093
18lysine metabolic process (GO:0006553)4.83483725
19lysine catabolic process (GO:0006554)4.83483725
20fructose metabolic process (GO:0006000)4.83366388
21skeletal muscle contraction (GO:0003009)4.82590172
22sarcoplasmic reticulum calcium ion transport (GO:0070296)4.80493413
23sarcomere organization (GO:0045214)4.72183408
24kynurenine metabolic process (GO:0070189)4.70579587
252-oxoglutarate metabolic process (GO:0006103)4.68782214
26aromatic amino acid family catabolic process (GO:0009074)4.59270008
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.56737222
28glyoxylate metabolic process (GO:0046487)4.55744326
29drug catabolic process (GO:0042737)4.46874252
30cardiac muscle contraction (GO:0060048)4.43052791
31actomyosin structure organization (GO:0031032)4.39995948
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35993314
33exogenous drug catabolic process (GO:0042738)4.32091584
34muscle system process (GO:0003012)4.31717863
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.27395120
36alpha-linolenic acid metabolic process (GO:0036109)4.23231315
37cellular ketone body metabolic process (GO:0046950)4.20612142
38aspartate family amino acid catabolic process (GO:0009068)4.20057245
39indole-containing compound catabolic process (GO:0042436)4.15631573
40indolalkylamine catabolic process (GO:0046218)4.15631573
41tryptophan catabolic process (GO:0006569)4.15631573
42glycogen catabolic process (GO:0005980)4.14925411
43regulation of triglyceride catabolic process (GO:0010896)4.11052346
44gluconeogenesis (GO:0006094)4.10418992
45bile acid biosynthetic process (GO:0006699)4.08201337
46tricarboxylic acid cycle (GO:0006099)4.07258672
47regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.05459190
48fatty acid beta-oxidation (GO:0006635)4.04045557
49myofibril assembly (GO:0030239)4.02777194
50muscle fiber development (GO:0048747)4.01419183
51plasma membrane repair (GO:0001778)4.01241306
52epoxygenase P450 pathway (GO:0019373)3.99894378
53regulation of cell communication by electrical coupling (GO:0010649)3.98868070
54skeletal muscle adaptation (GO:0043501)3.98476105
55regulation of actin filament-based movement (GO:1903115)3.94471662
56creatine metabolic process (GO:0006600)3.93522353
57acetyl-CoA metabolic process (GO:0006084)3.93508152
58glucan catabolic process (GO:0009251)3.93420103
59carnitine transmembrane transport (GO:1902603)3.92946734
60amino-acid betaine metabolic process (GO:0006577)3.91384347
61skeletal muscle tissue development (GO:0007519)3.91127296
62tryptophan metabolic process (GO:0006568)3.89107334
63cardiac muscle hypertrophy (GO:0003300)3.86471831
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84167104
65negative regulation of fibrinolysis (GO:0051918)3.83192464
66striated muscle adaptation (GO:0014888)3.82774123
67response to mercury ion (GO:0046689)3.79658619
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.74672612
69hexose biosynthetic process (GO:0019319)3.74625372
70skeletal muscle tissue regeneration (GO:0043403)3.74620160
71regulation of sequestering of triglyceride (GO:0010889)3.71302651
72amino-acid betaine transport (GO:0015838)3.71020204
73carnitine transport (GO:0015879)3.71020204
74glycogen metabolic process (GO:0005977)3.70926682
75regulation of protein activation cascade (GO:2000257)3.70924113
76fatty acid oxidation (GO:0019395)3.70421399
77dicarboxylic acid biosynthetic process (GO:0043650)3.70045669
78regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.69806991
79serine family amino acid catabolic process (GO:0009071)3.69473325
80actin filament-based movement (GO:0030048)3.69305744
81sulfur amino acid catabolic process (GO:0000098)3.69025611
82complement activation, alternative pathway (GO:0006957)3.68934176
83fatty acid catabolic process (GO:0009062)3.68788017
84regulation of fibrinolysis (GO:0051917)3.68635316
85striated muscle hypertrophy (GO:0014897)3.67800408
86cellular polysaccharide catabolic process (GO:0044247)3.67578631
87striated muscle contraction (GO:0006941)3.66006528
88high-density lipoprotein particle remodeling (GO:0034375)3.65684750
89short-chain fatty acid metabolic process (GO:0046459)3.65282647
90peptidyl-glutamic acid carboxylation (GO:0017187)3.64806461
91protein carboxylation (GO:0018214)3.64806461
92alpha-amino acid catabolic process (GO:1901606)3.64551243
93cysteine metabolic process (GO:0006534)3.64050866
94glucan metabolic process (GO:0044042)3.63306404
95cellular glucan metabolic process (GO:0006073)3.63306404
96lipid oxidation (GO:0034440)3.63186943
97regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.62447906
98urea cycle (GO:0000050)3.62201041
99urea metabolic process (GO:0019627)3.62201041
100ketone body metabolic process (GO:1902224)3.61958462
101positive regulation of fatty acid beta-oxidation (GO:0032000)3.54950340
102valine metabolic process (GO:0006573)3.54818098
103muscle cell cellular homeostasis (GO:0046716)3.54810175
104negative regulation of potassium ion transmembrane transport (GO:1901380)3.54280161
105monocarboxylic acid catabolic process (GO:0072329)3.52334558
106ethanol oxidation (GO:0006069)3.49311888
107acylglycerol homeostasis (GO:0055090)3.48602319
108triglyceride homeostasis (GO:0070328)3.48602319
109coenzyme catabolic process (GO:0009109)3.47365520
110regulation of complement activation (GO:0030449)3.46920113
111polysaccharide catabolic process (GO:0000272)3.46367015
112omega-hydroxylase P450 pathway (GO:0097267)3.46362941
113branched-chain amino acid catabolic process (GO:0009083)3.45066658
114homocysteine metabolic process (GO:0050667)3.41907261
115carnitine metabolic process (GO:0009437)3.41650723
116cardiac myofibril assembly (GO:0055003)3.41545965
117glucan biosynthetic process (GO:0009250)3.40302112
118glycogen biosynthetic process (GO:0005978)3.40302112
119muscle cell fate commitment (GO:0042693)3.39062676
120cellular amino acid catabolic process (GO:0009063)3.38766105
121bile acid metabolic process (GO:0008206)3.38139842
122oxaloacetate metabolic process (GO:0006107)3.37993506
123oxidative demethylation (GO:0070989)3.36614988
124nitrogen cycle metabolic process (GO:0071941)3.36231754
125response to activity (GO:0014823)3.33177323
126positive regulation of myotube differentiation (GO:0010831)3.33141396
127regulation of acyl-CoA biosynthetic process (GO:0050812)3.32890320
128muscle hypertrophy (GO:0014896)3.30738719
129aromatic amino acid family metabolic process (GO:0009072)3.30429284
130striated muscle atrophy (GO:0014891)3.30327010
131positive regulation of fatty acid oxidation (GO:0046321)3.30221066
132regulation of fatty acid oxidation (GO:0046320)3.30121519
133succinate metabolic process (GO:0006105)3.29648038
134monosaccharide biosynthetic process (GO:0046364)3.28853734
135pyrimidine nucleoside catabolic process (GO:0046135)3.28771895
136phospholipid homeostasis (GO:0055091)3.26938961
137blood coagulation, intrinsic pathway (GO:0007597)3.25235500
138organic acid catabolic process (GO:0016054)3.24109583
139carboxylic acid catabolic process (GO:0046395)3.24109583
140glutamate metabolic process (GO:0006536)3.23879750
141regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.21510063
142regulation of striated muscle contraction (GO:0006942)3.17535129
143muscle tissue morphogenesis (GO:0060415)3.15583023
144muscle organ development (GO:0007517)3.12489822
145muscle structure development (GO:0061061)3.11919963
146muscle organ morphogenesis (GO:0048644)3.11236054
147striated muscle cell development (GO:0055002)3.09174562
148muscle adaptation (GO:0043500)3.06837839
149positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.02377285
150cellular carbohydrate catabolic process (GO:0044275)3.01571607
151muscle atrophy (GO:0014889)3.00857503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.57221389
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.54735999
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.51728369
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.88603283
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.24338393
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45210271
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.30127264
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76817108
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.49118500
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.34221498
11EZH2_22144423_ChIP-Seq_EOC_Human3.00654696
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63122742
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.48704538
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17028857
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.05138391
16ZNF263_19887448_ChIP-Seq_K562_Human1.99938597
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99921409
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99444247
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94268438
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.89553399
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.89553399
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86797495
23CLOCK_20551151_ChIP-Seq_293T_Human1.84359854
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76659663
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74690849
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54165405
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.51314430
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51138934
29GATA1_22025678_ChIP-Seq_K562_Human1.47362603
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.46311820
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42847178
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38911603
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.32159885
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27500766
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25458657
36HTT_18923047_ChIP-ChIP_STHdh_Human1.24333037
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.21413002
38* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19208066
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16216584
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10872883
41SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09925242
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08521665
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.07146103
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.06796559
45IGF1R_20145208_ChIP-Seq_DFB_Human1.06656749
46DROSHA_22980978_ChIP-Seq_HELA_Human1.06159034
47PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05297846
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05111328
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04942865
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00040834
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99973331
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99880508
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99740775
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99466463
55* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99064792
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98104302
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97332971
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95644395
59OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95411948
60* GATA6_21074721_ChIP-Seq_CACO-2_Human0.95205233
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94534960
62ESR1_21235772_ChIP-Seq_MCF-7_Human0.90038115
63STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89510774
64LXR_22292898_ChIP-Seq_THP-1_Human0.87659057
65GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87129616
66* CTCF_27219007_Chip-Seq_Bcells_Human0.86660803
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85972867
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85371227
69RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84174787
70* PHF8_20622853_ChIP-Seq_HELA_Human0.83600552
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82814862
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82195243
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81378246
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80415994
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80415994
76CEBPB_22108803_ChIP-Seq_LS180_Human0.80178505
77OCT4_20526341_ChIP-Seq_ESCs_Human0.79832958
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78727111
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78382577
80* HNFA_21074721_ChIP-Seq_CACO-2_Human0.77950878
81* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77879556
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.76218284
83AR_21572438_ChIP-Seq_LNCaP_Human0.75789213
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75128455
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75114665
86* EZH2_27294783_Chip-Seq_ESCs_Mouse0.74962008
87ERG_21242973_ChIP-ChIP_JURKAT_Human0.71852744
88SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71401273
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71001021
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70832174
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70797259
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69081960
93MYC_27129775_Chip-Seq_CORNEA_Mouse0.68628934
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68602528
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.68419136
96* GATA3_21867929_ChIP-Seq_CD8_Mouse0.68331864
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68124035
98CBP_21632823_ChIP-Seq_H3396_Human0.68025636
99GATA1_19941826_ChIP-Seq_K562_Human0.67791734
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.66749124
101STAT1_20625510_ChIP-Seq_HELA_Human0.66600510
102RACK7_27058665_Chip-Seq_MCF-7_Human0.65517330
103* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.65461659
104EGR1_19032775_ChIP-ChIP_M12_Human0.64446171
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.63746774
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.63733418
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.63186362
108SPI1_20517297_ChIP-Seq_HL60_Human0.63049156
109SMC3_22415368_ChIP-Seq_MEFs_Mouse0.61645326
110* CTCF_21964334_Chip-Seq_Bcells_Human0.61476752
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61086117
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60676784
113BCL6_27268052_Chip-Seq_Bcells_Human0.60513119
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60399875
115TAF2_19829295_ChIP-Seq_ESCs_Human0.59460696
116P68_20966046_ChIP-Seq_HELA_Human0.59390157
117BCOR_27268052_Chip-Seq_Bcells_Human0.58910985
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58880587
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58390527
120CSB_26484114_Chip-Seq_FIBROBLAST_Human0.58073633
121CREB1_26743006_Chip-Seq_LNCaP_Human0.57919122
122* SA1_27219007_Chip-Seq_Bcells_Human0.57549891
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56898651
124* GATA2_19941826_ChIP-Seq_K562_Human0.56893790
125LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.56452824
126NANOG_20526341_ChIP-Seq_ESCs_Human0.55444944
127TP63_22573176_ChIP-Seq_HFKS_Human0.55421775
128BCAT_22108803_ChIP-Seq_LS180_Human0.54801943
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.54262619
130* RAC3_21632823_ChIP-Seq_H3396_Human0.53758359
131E2F1_20622854_ChIP-Seq_HELA_Human0.53713653
132P53_21459846_ChIP-Seq_SAOS-2_Human0.53649840
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.53360879
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.53239864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.01427110
2MP0003646_muscle_fatigue4.81473086
3MP0002837_dystrophic_cardiac_calcinosis4.36660440
4MP0005360_urolithiasis4.28659504
5MP0000751_myopathy4.06796926
6MP0005085_abnormal_gallbladder_physiolo4.05717365
7MP0000749_muscle_degeneration4.01967642
8MP0004145_abnormal_muscle_electrophysio3.82653814
9MP0005365_abnormal_bile_salt3.62818450
10MP0003806_abnormal_nucleotide_metabolis3.42835185
11MP0004036_abnormal_muscle_relaxation3.16306592
12MP0008875_abnormal_xenobiotic_pharmacok2.90426958
13MP0004130_abnormal_muscle_cell2.83298623
14MP0000747_muscle_weakness2.63035969
15MP0002269_muscular_atrophy2.54644476
16MP0004087_abnormal_muscle_fiber2.52507415
17MP0002106_abnormal_muscle_physiology2.52197751
18MP0004084_abnormal_cardiac_muscle2.49455419
19MP0003252_abnormal_bile_duct2.46688112
20MP0005330_cardiomyopathy2.35417780
21MP0005083_abnormal_biliary_tract2.26501818
22MP0010329_abnormal_lipoprotein_level2.23413650
23MP0005620_abnormal_muscle_contractility2.20559280
24MP0000759_abnormal_skeletal_muscle2.20015445
25MP0009840_abnormal_foam_cell2.19712131
26MP0000750_abnormal_muscle_regeneration2.16099284
27MP0004215_abnormal_myocardial_fiber2.11505080
28MP0006036_abnormal_mitochondrial_physio2.08075003
29MP0005369_muscle_phenotype2.06093361
30MP0003195_calcinosis2.02299257
31MP0005332_abnormal_amino_acid1.77072566
32MP0002972_abnormal_cardiac_muscle1.56475432
33MP0002332_abnormal_exercise_endurance1.54654329
34MP0002118_abnormal_lipid_homeostasis1.52533684
35MP0005319_abnormal_enzyme/_coenzyme1.51039155
36MP0001666_abnormal_nutrient_absorption1.47831024
37MP0004233_abnormal_muscle_weight1.43326412
38MP0010630_abnormal_cardiac_muscle1.41455056
39MP0003191_abnormal_cellular_cholesterol1.39444644
40MP0005666_abnormal_adipose_tissue1.38155233
41MP0000013_abnormal_adipose_tissue1.36197595
42* MP0000609_abnormal_liver_physiology1.34353782
43MP0005385_cardiovascular_system_phenoty1.33623167
44MP0001544_abnormal_cardiovascular_syste1.33623167
45MP0001661_extended_life_span1.33123552
46MP0002971_abnormal_brown_adipose1.30754447
47MP0006035_abnormal_mitochondrial_morpho1.26321380
48MP0003705_abnormal_hypodermis_morpholog1.25114319
49MP0005584_abnormal_enzyme/coenzyme_acti1.25107396
50MP0003221_abnormal_cardiomyocyte_apopto1.23982143
51MP0003137_abnormal_impulse_conducting1.23077772
52MP0008775_abnormal_heart_ventricle1.21693785
53MP0004484_altered_response_of1.21110536
54MP0005266_abnormal_metabolism1.20865180
55MP0004270_analgesia1.20004814
56MP0003656_abnormal_erythrocyte_physiolo1.19224661
57MP0005451_abnormal_body_composition1.17996492
58MP0005670_abnormal_white_adipose1.16557848
59MP0004185_abnormal_adipocyte_glucose1.13583659
60MP0002108_abnormal_muscle_morphology1.09165123
61MP0002138_abnormal_hepatobiliary_system1.06574300
62MP0006138_congestive_heart_failure1.03751289
63MP0002078_abnormal_glucose_homeostasis0.93764433
64MP0000733_abnormal_muscle_development0.92119507
65MP0002876_abnormal_thyroid_physiology0.92090843
66MP0010368_abnormal_lymphatic_system0.87206529
67MP0003879_abnormal_hair_cell0.83775398
68MP0005375_adipose_tissue_phenotype0.82800990
69MP0003868_abnormal_feces_composition0.81115600
70MP0004085_abnormal_heartbeat0.81093009
71MP0005334_abnormal_fat_pad0.80859856
72MP0000003_abnormal_adipose_tissue0.80376484
73MP0004019_abnormal_vitamin_homeostasis0.80258840
74MP0001764_abnormal_homeostasis0.79851393
75MP0002127_abnormal_cardiovascular_syste0.75184789
76MP0003950_abnormal_plasma_membrane0.73966862
77MP0009697_abnormal_copulation0.72281835
78MP0009643_abnormal_urine_homeostasis0.71339317
79MP0005376_homeostasis/metabolism_phenot0.68256638
80MP0005535_abnormal_body_temperature0.66171833
81MP0003186_abnormal_redox_activity0.63228878
82MP0000230_abnormal_systemic_arterial0.62966701
83MP0004043_abnormal_pH_regulation0.62416008
84MP0000343_altered_response_to0.62403120
85MP0004147_increased_porphyrin_level0.61763557
86* MP0000598_abnormal_liver_morphology0.61253532
87MP0005187_abnormal_penis_morphology0.57920655
88MP0009780_abnormal_chondrocyte_physiolo0.56777031
89MP0003011_delayed_dark_adaptation0.55311049
90MP0004510_myositis0.54795104
91MP0003828_pulmonary_edema0.53919979
92* MP0009642_abnormal_blood_homeostasis0.53680723
93MP0002822_catalepsy0.52838650
94MP0005165_increased_susceptibility_to0.52207674
95MP0003045_fibrosis0.51754647
96MP0009763_increased_sensitivity_to0.50628212
97* MP0000266_abnormal_heart_morphology0.50200355
98MP0009672_abnormal_birth_weight0.47230368
99MP0005647_abnormal_sex_gland0.45864951
100MP0000372_irregular_coat_pigmentation0.45717166
101MP0005166_decreased_susceptibility_to0.44857665
102MP0009764_decreased_sensitivity_to0.44272234
103MP0002128_abnormal_blood_circulation0.43733197
104MP0008469_abnormal_protein_level0.42568940
105MP0009115_abnormal_fat_cell0.42300307
106MP0002234_abnormal_pharynx_morphology0.41459120
107MP0004142_abnormal_muscle_tone0.40801438
108MP0000604_amyloidosis0.40422591
109MP0008961_abnormal_basal_metabolism0.40415430
110MP0005448_abnormal_energy_balance0.40069590
111MP0004134_abnormal_chest_morphology0.39766477
112MP0005167_abnormal_blood-brain_barrier0.39454693
113* MP0005636_abnormal_mineral_homeostasis0.38435308
114MP0001853_heart_inflammation0.36106963
115MP0000579_abnormal_nail_morphology0.35912906
116MP0002249_abnormal_larynx_morphology0.35016950
117MP0008874_decreased_physiological_sensi0.33610622
118MP0005452_abnormal_adipose_tissue0.33593722
119MP0001299_abnormal_eye_distance/0.30526616
120MP0003959_abnormal_lean_body0.29198283
121MP0002638_abnormal_pupillary_reflex0.26077500
122MP0003948_abnormal_gas_homeostasis0.25795515

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.80014692
2Exercise-induced muscle cramps (HP:0003710)6.26413218
3Muscle fiber inclusion bodies (HP:0100299)6.08040514
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.85181480
5Muscle hypertrophy of the lower extremities (HP:0008968)5.59753648
6Calf muscle hypertrophy (HP:0008981)5.35811763
7Nemaline bodies (HP:0003798)5.35398873
8Myoglobinuria (HP:0002913)5.14773029
9Type 1 muscle fiber predominance (HP:0003803)4.56853491
10Muscle fiber splitting (HP:0003555)4.35875267
11Hyporeflexia of lower limbs (HP:0002600)4.29643115
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.26882406
13Distal arthrogryposis (HP:0005684)4.23806672
14Rhabdomyolysis (HP:0003201)4.20960378
15Difficulty running (HP:0009046)4.03469761
16Sudden death (HP:0001699)3.88881902
17Myopathic facies (HP:0002058)3.80945505
18EMG: myopathic abnormalities (HP:0003458)3.77375004
19Abnormality of the calf musculature (HP:0001430)3.76079300
20Round ear (HP:0100830)3.72236981
21Deep venous thrombosis (HP:0002625)3.63879209
22Intrahepatic cholestasis (HP:0001406)3.63549028
23Increased connective tissue (HP:0009025)3.61671880
24Muscle stiffness (HP:0003552)3.61390489
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47125710
26Xanthomatosis (HP:0000991)3.40012015
27Ketosis (HP:0001946)3.36572834
28Ulnar deviation of the wrist (HP:0003049)3.36231596
29Hypoalphalipoproteinemia (HP:0003233)3.29636986
30Hypoglycemic coma (HP:0001325)3.23768467
31Ventricular tachycardia (HP:0004756)3.20664114
32Hypobetalipoproteinemia (HP:0003563)3.20443998
33Myotonia (HP:0002486)3.19078780
34Subaortic stenosis (HP:0001682)3.16099325
35Abnormality of the left ventricular outflow tract (HP:0011103)3.16099325
36Hyperammonemia (HP:0001987)3.15151559
37Hypolipoproteinemia (HP:0010981)3.10539454
38Asymmetric septal hypertrophy (HP:0001670)3.07479432
39Ketoacidosis (HP:0001993)3.05084260
40Abnormality of monocarboxylic acid metabolism (HP:0010996)3.04065709
41Hyperlipoproteinemia (HP:0010980)3.02350143
42Absent phalangeal crease (HP:0006109)3.01823243
43Abnormality of fatty-acid metabolism (HP:0004359)2.89542111
44Prolonged partial thromboplastin time (HP:0003645)2.88120692
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79379700
46Fetal akinesia sequence (HP:0001989)2.74566194
47Hyperglycinuria (HP:0003108)2.71587707
48Generalized muscle weakness (HP:0003324)2.70197104
49Difficulty climbing stairs (HP:0003551)2.68976407
50Calcaneovalgus deformity (HP:0001848)2.67102820
51Abnormality of skeletal muscle fiber size (HP:0012084)2.66806760
52Hyperglycinemia (HP:0002154)2.66776113
53Cholelithiasis (HP:0001081)2.66505903
54Abnormality of serine family amino acid metabolism (HP:0010894)2.61753185
55Abnormality of glycine metabolism (HP:0010895)2.61753185
56Right ventricular cardiomyopathy (HP:0011663)2.59100211
57Complement deficiency (HP:0004431)2.55847664
58Mildly elevated creatine phosphokinase (HP:0008180)2.54934367
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53564691
60Dicarboxylic aciduria (HP:0003215)2.52298550
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52298550
62Abnormal gallbladder morphology (HP:0012437)2.51859627
63Lipoatrophy (HP:0100578)2.51631699
64Bulbar palsy (HP:0001283)2.51613990
65Increased variability in muscle fiber diameter (HP:0003557)2.50532414
66Cerebral edema (HP:0002181)2.48827275
67Gowers sign (HP:0003391)2.47682857
68Areflexia of lower limbs (HP:0002522)2.46482022
69Abnormal finger flexion creases (HP:0006143)2.44791765
70Palpitations (HP:0001962)2.42013477
71Abnormality of the calcaneus (HP:0008364)2.41604921
72Malignant hyperthermia (HP:0002047)2.41008039
73Weak cry (HP:0001612)2.40799680
74Deformed tarsal bones (HP:0008119)2.40558268
75Rimmed vacuoles (HP:0003805)2.35591681
76Dilated cardiomyopathy (HP:0001644)2.34736150
77Neck muscle weakness (HP:0000467)2.34013222
78Slender build (HP:0001533)2.32930521
79Fatigable weakness (HP:0003473)2.31579660
80Abnormality of the neuromuscular junction (HP:0003398)2.31579660
81Gout (HP:0001997)2.31107537
82Limb-girdle muscle atrophy (HP:0003797)2.29041902
83Metabolic acidosis (HP:0001942)2.27307696
84Epidermoid cyst (HP:0200040)2.26570020
85Distal lower limb amyotrophy (HP:0008944)2.25093904
86Distal lower limb muscle weakness (HP:0009053)2.21098002
87Scapular winging (HP:0003691)2.20150140
88Hyperkalemia (HP:0002153)2.13865489
89Bundle branch block (HP:0011710)2.09858312
90Hepatic necrosis (HP:0002605)2.09725275
91Atrial fibrillation (HP:0005110)2.09186963
92Hip contracture (HP:0003273)2.08770994
93Heart block (HP:0012722)2.08463602
94EMG: neuropathic changes (HP:0003445)2.08074694
95Frequent falls (HP:0002359)2.07086384
96Progressive muscle weakness (HP:0003323)2.06743025
97Hyperinsulinemic hypoglycemia (HP:0000825)2.05774472
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03938149
99Joint hemorrhage (HP:0005261)2.02860742
100Abnormality of methionine metabolism (HP:0010901)2.02497989
101Abnormality of serum amino acid levels (HP:0003112)2.01620928
102Lethargy (HP:0001254)2.01396239
103Atrioventricular block (HP:0001678)2.01160981
104Hyperglycemia (HP:0003074)2.01002707
105Abnormality of the common coagulation pathway (HP:0010990)1.99891599
106Spinal rigidity (HP:0003306)1.99080849
107Abnormality of purine metabolism (HP:0004352)1.98416800
108Increased purine levels (HP:0004368)1.96668986
109Hyperuricemia (HP:0002149)1.96668986
110Popliteal pterygium (HP:0009756)1.96522599
111Increased muscle lipid content (HP:0009058)1.95746677
112Acute encephalopathy (HP:0006846)1.95374289
113Abnormal atrioventricular conduction (HP:0005150)1.95181008
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.94485302
115Late onset (HP:0003584)1.94240915
116Hyperbilirubinemia (HP:0002904)1.92934470
117Primary atrial arrhythmia (HP:0001692)1.91017469
118Skin nodule (HP:0200036)1.90311922
119Abnormality of the Achilles tendon (HP:0005109)1.88384353
120Proximal amyotrophy (HP:0007126)1.83331319
121Waddling gait (HP:0002515)1.83085393
122Muscular dystrophy (HP:0003560)1.82993781
123Abnormality of the foot musculature (HP:0001436)1.81418362
124Metatarsus adductus (HP:0001840)1.79883933
125Long clavicles (HP:0000890)1.76044934
126Abnormality of the shoulder girdle musculature (HP:0001435)1.73904783
127Paralysis (HP:0003470)1.70708798
128Ragged-red muscle fibers (HP:0003200)1.68845266
129Foot dorsiflexor weakness (HP:0009027)1.68766911
130Exercise intolerance (HP:0003546)1.68159718
131Respiratory insufficiency due to muscle weakness (HP:0002747)1.68147304
132Lower limb amyotrophy (HP:0007210)1.65784830
133Type 2 muscle fiber atrophy (HP:0003554)1.63887096
134Nonprogressive disorder (HP:0003680)1.60406666
135Limb-girdle muscle weakness (HP:0003325)1.53274236
136Abnormality of complement system (HP:0005339)1.53073840
137Ulnar deviation of finger (HP:0009465)1.49868960
138Muscle fiber atrophy (HP:0100295)1.49466038
139Reduced antithrombin III activity (HP:0001976)1.48558980
140Ventricular arrhythmia (HP:0004308)1.48111120
141Facial diplegia (HP:0001349)1.47192891
142Abnormality of the musculature of the pelvis (HP:0001469)1.45633607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.17739237
2TTN5.86108065
3PHKG24.51369741
4PHKG14.51369741
5BCKDK4.31229834
6PIK3CG2.83446371
7PDK32.67305423
8PDK42.67305423
9TRIB32.64395494
10PINK12.49511550
11MAP2K32.31710097
12PKN22.23528651
13NEK12.11447440
14NME12.00130079
15MAP3K71.97630878
16PIK3CA1.81155964
17SIK11.78879454
18MAP2K41.73950483
19PDK21.62426133
20DMPK1.61848660
21MAPK121.56378294
22FGFR41.54354087
23MUSK1.50544039
24ERN11.41356650
25INSRR1.40293132
26NEK91.20237549
27MYLK1.19427890
28PRKAA21.17800465
29TIE11.15965737
30LMTK21.14766662
31MAP2K61.06122562
32MAPK111.03180034
33PRKAA11.02088185
34FLT30.98585725
35EEF2K0.97861813
36MAP3K30.96417818
37MARK10.95702759
38STK240.91607295
39MOS0.91352662
40CCNB10.88416613
41LIMK10.85015439
42PTK60.79949207
43EPHB10.72198481
44CAMK2G0.71787877
45RIPK10.71254993
46MAPKAPK30.67400821
47LATS10.66000453
48MAP3K50.65276941
49PRKD10.61097772
50ERBB30.60435325
51STK38L0.59750005
52MAP3K110.58387666
53TYK20.58187917
54PKN10.57027578
55ERBB40.56655099
56MAP3K130.56414140
57TAOK20.54578034
58KSR20.54572250
59KDR0.51057287
60PAK30.50801546
61CAMK2D0.50564439
62GRK70.49670567
63TRPM70.49077238
64MAP3K100.46805961
65AKT20.46449015
66JAK20.43734515
67TGFBR20.43659014
68PDPK10.43293655
69MST1R0.42837407
70MAPK40.42780049
71ILK0.42549114
72PRKACG0.42199714
73CAMK2B0.40340979
74PRKACB0.40057269
75CAMK40.39192023
76ROCK10.36983133
77ZAK0.36657507
78TAOK30.36311188
79ICK0.36296644
80MAPK70.36026907
81PRPF4B0.35615641
82JAK10.34440161
83CAMK10.33159309
84ABL20.33016211
85PDK10.31177121
86PRKACA0.30379979
87RPS6KB10.29969676
88SGK30.29361934
89PDGFRA0.29133562
90MAP3K10.27925645
91SGK20.27340342
92TAOK10.26123323
93MAP3K60.25845310
94MAP2K10.25733024
95MAPK100.24605830
96TBK10.24456806
97RPS6KA30.23824889
98PRKG10.23274756
99DYRK1B0.23190036
100MTOR0.22403157
101CAMK2A0.22357384
102DAPK20.22012648
103ARAF0.21148405
104STK380.20981669
105SGK10.18176087
106LATS20.17380840
107RET0.17081055
108MAPK130.16911637
109ZAP700.16544134
110GSK3A0.16251803
111RPS6KA10.15668594
112FGFR30.15202789
113EPHA30.13844676
114RPS6KB20.13798154
115PTK2B0.13468000
116PRKCQ0.13106027
117SGK4940.12642473
118SGK2230.12642473
119RPS6KL10.12094620
120RPS6KC10.12094620
121CAMK1D0.11673103
122RAF10.11219909
123MARK20.11042946
124CAMK1G0.10511672
125TNK20.09114094
126RPS6KA60.07926864
127CSNK1D0.07899766
128NLK0.06553734
129STK110.05760709
130MAPK30.04712739
131PRKCA0.04317497
132CDK190.03269794
133MAPK90.02767668
134MAP2K20.02659866

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.00158298
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.36979998
3Fatty acid degradation_Homo sapiens_hsa000713.08533797
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06499162
5Propanoate metabolism_Homo sapiens_hsa006402.96508292
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.92561775
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84394127
8Arginine biosynthesis_Homo sapiens_hsa002202.77060247
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70145159
10Nitrogen metabolism_Homo sapiens_hsa009102.66840645
11Tryptophan metabolism_Homo sapiens_hsa003802.36128814
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27702467
13Fatty acid metabolism_Homo sapiens_hsa012122.26356372
14Butanoate metabolism_Homo sapiens_hsa006502.16036508
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13303012
16Carbon metabolism_Homo sapiens_hsa012002.04276986
17Complement and coagulation cascades_Homo sapiens_hsa046101.93176755
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91008719
19Pyruvate metabolism_Homo sapiens_hsa006201.89583935
20Starch and sucrose metabolism_Homo sapiens_hsa005001.88502288
21PPAR signaling pathway_Homo sapiens_hsa033201.87190667
22Peroxisome_Homo sapiens_hsa041461.84881448
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66176860
24beta-Alanine metabolism_Homo sapiens_hsa004101.64161867
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62641536
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58544427
27Biosynthesis of amino acids_Homo sapiens_hsa012301.55067967
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47879549
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47294659
30Fatty acid elongation_Homo sapiens_hsa000621.45209882
31Cardiac muscle contraction_Homo sapiens_hsa042601.40625685
32Phenylalanine metabolism_Homo sapiens_hsa003601.37833294
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33832201
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33301489
35Chemical carcinogenesis_Homo sapiens_hsa052041.31060322
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26904762
37Caffeine metabolism_Homo sapiens_hsa002321.25685246
38Histidine metabolism_Homo sapiens_hsa003401.21233130
39Arginine and proline metabolism_Homo sapiens_hsa003301.20773801
40Dilated cardiomyopathy_Homo sapiens_hsa054141.17192353
41Tyrosine metabolism_Homo sapiens_hsa003501.16944130
42Bile secretion_Homo sapiens_hsa049761.15520913
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.12206439
44Staphylococcus aureus infection_Homo sapiens_hsa051501.06945003
45Selenocompound metabolism_Homo sapiens_hsa004501.06612367
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.04911263
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04629492
48Retinol metabolism_Homo sapiens_hsa008301.04121557
49Sulfur metabolism_Homo sapiens_hsa009201.02956879
50Fat digestion and absorption_Homo sapiens_hsa049750.98715508
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97459117
52Parkinsons disease_Homo sapiens_hsa050120.95668729
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95140618
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.93678523
55ABC transporters_Homo sapiens_hsa020100.93007520
56Oxidative phosphorylation_Homo sapiens_hsa001900.90008838
57Insulin resistance_Homo sapiens_hsa049310.88790132
58Lysine degradation_Homo sapiens_hsa003100.84566924
59Glucagon signaling pathway_Homo sapiens_hsa049220.83857624
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82478889
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.80419177
62Galactose metabolism_Homo sapiens_hsa000520.73221779
63Alzheimers disease_Homo sapiens_hsa050100.72176590
64Sulfur relay system_Homo sapiens_hsa041220.71279485
65Fatty acid biosynthesis_Homo sapiens_hsa000610.69541000
66Pentose phosphate pathway_Homo sapiens_hsa000300.67599296
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65445304
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65007359
69Folate biosynthesis_Homo sapiens_hsa007900.63850877
70Insulin signaling pathway_Homo sapiens_hsa049100.63130533
71Fructose and mannose metabolism_Homo sapiens_hsa000510.62052570
72AMPK signaling pathway_Homo sapiens_hsa041520.55284003
73Glycerolipid metabolism_Homo sapiens_hsa005610.52379995
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51356926
75Vitamin B6 metabolism_Homo sapiens_hsa007500.49150146
76Metabolic pathways_Homo sapiens_hsa011000.46811716
77Arachidonic acid metabolism_Homo sapiens_hsa005900.40335424
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40065597
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.40050800
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39206399
81Glutathione metabolism_Homo sapiens_hsa004800.34952545
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.34510737
83Huntingtons disease_Homo sapiens_hsa050160.34114653
84Circadian rhythm_Homo sapiens_hsa047100.32390101
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28644917
86Steroid biosynthesis_Homo sapiens_hsa001000.28586150
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27548750
88Tight junction_Homo sapiens_hsa045300.27540126
89Vitamin digestion and absorption_Homo sapiens_hsa049770.27252803
90Viral myocarditis_Homo sapiens_hsa054160.23953707
91Gastric acid secretion_Homo sapiens_hsa049710.22723026
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22156637
93Renin secretion_Homo sapiens_hsa049240.21892380
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.18546801
95Linoleic acid metabolism_Homo sapiens_hsa005910.14293591
96Prion diseases_Homo sapiens_hsa050200.14091012
97FoxO signaling pathway_Homo sapiens_hsa040680.12114212
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.11703817
99Long-term potentiation_Homo sapiens_hsa047200.10565189
100GnRH signaling pathway_Homo sapiens_hsa049120.10370443
101Calcium signaling pathway_Homo sapiens_hsa040200.10299303
102Oxytocin signaling pathway_Homo sapiens_hsa049210.10128593
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08977174
104Amoebiasis_Homo sapiens_hsa051460.08525947
105Pertussis_Homo sapiens_hsa051330.06355047
106Insulin secretion_Homo sapiens_hsa049110.05650039
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05223824
108One carbon pool by folate_Homo sapiens_hsa006700.04102115
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02313562
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02070763
111Type II diabetes mellitus_Homo sapiens_hsa049300.01758488
112Focal adhesion_Homo sapiens_hsa04510-0.0571111
113Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0006949

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