HFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.52720329
2male meiosis (GO:0007140)8.91244801
3synaptonemal complex organization (GO:0070193)8.18619053
4DNA methylation involved in gamete generation (GO:0043046)8.06281984
5synaptonemal complex assembly (GO:0007130)7.95642738
6fusion of sperm to egg plasma membrane (GO:0007342)7.21526768
7male meiosis I (GO:0007141)6.97309230
8sperm motility (GO:0030317)6.47657750
9axonemal dynein complex assembly (GO:0070286)6.35109746
10regulation of meiosis I (GO:0060631)6.29124036
11chromosome organization involved in meiosis (GO:0070192)6.22301181
12meiotic nuclear division (GO:0007126)5.96010574
13spermatid development (GO:0007286)5.81645961
14epithelial cilium movement (GO:0003351)5.77797657
15acrosome assembly (GO:0001675)5.76233792
16multicellular organism reproduction (GO:0032504)5.71269279
17meiosis I (GO:0007127)5.65597182
18plasma membrane fusion (GO:0045026)5.63176511
19acrosome reaction (GO:0007340)5.56967901
20sperm-egg recognition (GO:0035036)5.56827444
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.54998488
22motile cilium assembly (GO:0044458)5.33264697
23cilium movement (GO:0003341)5.11826872
24binding of sperm to zona pellucida (GO:0007339)5.07923020
25cell-cell recognition (GO:0009988)4.96253398
26microtubule depolymerization (GO:0007019)4.65467645
27synapsis (GO:0007129)4.62866553
28reproduction (GO:0000003)4.34441078
29meiotic cell cycle (GO:0051321)4.27449060
30germ cell development (GO:0007281)4.13990196
31single fertilization (GO:0007338)4.10463575
32gene silencing by RNA (GO:0031047)4.09228076
33* meiotic cell cycle process (GO:1903046)4.08231441
34pyrimidine nucleobase catabolic process (GO:0006208)4.05510708
35protein localization to cilium (GO:0061512)4.03457837
36cell wall macromolecule metabolic process (GO:0044036)4.02799912
37cell wall macromolecule catabolic process (GO:0016998)4.02799912
38fertilization (GO:0009566)4.00511572
39spermatogenesis (GO:0007283)3.93240883
40male gamete generation (GO:0048232)3.92157736
41regulation of cilium movement (GO:0003352)3.75733913
42cellular process involved in reproduction in multicellular organism (GO:0022412)3.75422485
43intraciliary transport (GO:0042073)3.73930698
44presynaptic membrane assembly (GO:0097105)3.70019530
45DNA alkylation (GO:0006305)3.69663798
46DNA methylation (GO:0006306)3.69663798
47gamete generation (GO:0007276)3.63627494
48positive regulation of meiosis (GO:0045836)3.47588667
49* resolution of meiotic recombination intermediates (GO:0000712)3.42906893
50monoubiquitinated protein deubiquitination (GO:0035520)3.40807829
51calcium ion-dependent exocytosis (GO:0017156)3.38584193
52sperm capacitation (GO:0048240)3.38073992
53sex differentiation (GO:0007548)3.34761356
54nonmotile primary cilium assembly (GO:0035058)3.33489489
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.33313152
56centriole replication (GO:0007099)3.32252439
57presynaptic membrane organization (GO:0097090)3.29749060
58negative regulation of meiosis (GO:0045835)3.28611297
59retinal ganglion cell axon guidance (GO:0031290)3.26541358
60nucleobase catabolic process (GO:0046113)3.25783567
61reciprocal meiotic recombination (GO:0007131)3.24458384
62reciprocal DNA recombination (GO:0035825)3.24458384
63ventricular system development (GO:0021591)3.24041575
64positive regulation of meiotic cell cycle (GO:0051446)3.21808480
65negative regulation of inclusion body assembly (GO:0090084)3.19819304
66cell recognition (GO:0008037)3.19190710
67neural tube formation (GO:0001841)3.18864788
68regulation of centriole replication (GO:0046599)3.14325851
69protein localization to synapse (GO:0035418)3.09223499
70meiotic chromosome segregation (GO:0045132)3.06707106
71neuron fate determination (GO:0048664)3.04861810
72microtubule severing (GO:0051013)3.03750920
73positive regulation of mitochondrial fission (GO:0090141)3.00433088
74sister chromatid cohesion (GO:0007062)2.99447768
75DNA double-strand break processing (GO:0000729)2.98028376
76protein polyglutamylation (GO:0018095)2.96777147
77regulation of inclusion body assembly (GO:0090083)2.96572590
78nuclear pore complex assembly (GO:0051292)2.95939387
79centriole assembly (GO:0098534)2.95588778
80cilium organization (GO:0044782)2.93024772
81sequestering of actin monomers (GO:0042989)2.92964406
82cilium assembly (GO:0042384)2.91045688
83neuron cell-cell adhesion (GO:0007158)2.89619081
84oogenesis (GO:0048477)2.89300239
85DNA methylation or demethylation (GO:0044728)2.87015052
86limb bud formation (GO:0060174)2.85515136
87axonal fasciculation (GO:0007413)2.83687820
88microtubule polymerization or depolymerization (GO:0031109)2.82388157
89negative regulation of organelle assembly (GO:1902116)2.81812911
90neuron recognition (GO:0008038)2.79972570
91gene silencing (GO:0016458)2.77758917
92protein K11-linked deubiquitination (GO:0035871)2.77422959
93multicellular organismal reproductive process (GO:0048609)2.76778590
94microtubule-based movement (GO:0007018)2.76284948
95behavioral response to nicotine (GO:0035095)2.75449647
96tongue development (GO:0043586)2.74297987
97postsynaptic membrane organization (GO:0001941)2.73124482
98urinary tract smooth muscle contraction (GO:0014848)2.72035479
99axoneme assembly (GO:0035082)2.71997133
100replicative senescence (GO:0090399)2.70856745
101transmission of nerve impulse (GO:0019226)2.69885508
102histone exchange (GO:0043486)2.68869176
103rRNA catabolic process (GO:0016075)2.68465760
104genitalia morphogenesis (GO:0035112)2.67963345
105DNA synthesis involved in DNA repair (GO:0000731)2.66340939
106regulation of spindle checkpoint (GO:0090231)2.65764068
107translesion synthesis (GO:0019985)2.64895060
108regulation of chromatin binding (GO:0035561)2.64607809
109positive regulation of translational initiation (GO:0045948)2.62596500
110nuclear pore organization (GO:0006999)2.59460646
111seminiferous tubule development (GO:0072520)2.58207594
112histone H2A acetylation (GO:0043968)2.57769523
113regulation of microtubule-based movement (GO:0060632)2.56981345
114chromatin remodeling at centromere (GO:0031055)2.56819613
115cilium morphogenesis (GO:0060271)2.55928509
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.52222650
117regulation of collateral sprouting (GO:0048670)2.51851999
118regulation of protein polyubiquitination (GO:1902914)2.51227353
119central nervous system projection neuron axonogenesis (GO:0021952)2.50736968
120somite development (GO:0061053)2.50078685
121cellular component assembly involved in morphogenesis (GO:0010927)2.49713520
122regulation of meiosis (GO:0040020)2.49212195
123female gamete generation (GO:0007292)2.49133003
124olfactory bulb development (GO:0021772)2.47750349
125DNA damage response, detection of DNA damage (GO:0042769)2.45649867
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.43881309
127NADH dehydrogenase complex assembly (GO:0010257)2.43881309
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43881309
129gamma-aminobutyric acid transport (GO:0015812)2.42357174
130histone H4-K12 acetylation (GO:0043983)2.41644617
131striatum development (GO:0021756)2.41586782
132central nervous system neuron axonogenesis (GO:0021955)2.39862196
133regulation of development, heterochronic (GO:0040034)2.39346572
134CENP-A containing nucleosome assembly (GO:0034080)2.39130858
135replication fork processing (GO:0031297)2.36661906
136DNA integration (GO:0015074)2.36627579
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31570880
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.31570880
139mismatch repair (GO:0006298)2.31525963
140photoreceptor cell maintenance (GO:0045494)2.30328844
141regulation of timing of cell differentiation (GO:0048505)2.29826632
142microtubule anchoring (GO:0034453)2.28227827
143behavioral response to ethanol (GO:0048149)2.26871566
144recombinational repair (GO:0000725)2.25871845
145protein complex biogenesis (GO:0070271)2.25065635
146appendage development (GO:0048736)2.23638401
147limb development (GO:0060173)2.23638401
148C4-dicarboxylate transport (GO:0015740)2.22834386
149double-strand break repair via homologous recombination (GO:0000724)2.22550209
150calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20844110
151neurotransmitter-gated ion channel clustering (GO:0072578)2.19776612
152spinal cord motor neuron differentiation (GO:0021522)2.19091749
153forebrain neuron differentiation (GO:0021879)2.18076288
154mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.17656227
155cullin deneddylation (GO:0010388)2.16470495
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.16025599
157piRNA metabolic process (GO:0034587)11.1818643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95883247
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.87691122
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19255119
4GBX2_23144817_ChIP-Seq_PC3_Human3.08017561
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97469881
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.94456189
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93188326
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90183476
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77168382
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14195451
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11695500
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03633213
13* RNF2_27304074_Chip-Seq_NSC_Mouse1.99455301
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99307982
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.98885496
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98220931
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95937788
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.95400493
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88139032
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83427540
21REST_21632747_ChIP-Seq_MESCs_Mouse1.83207328
22FUS_26573619_Chip-Seq_HEK293_Human1.80554058
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80260678
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78971463
25* TAF15_26573619_Chip-Seq_HEK293_Human1.76034037
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72743584
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71523945
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71267978
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71267978
30VDR_22108803_ChIP-Seq_LS180_Human1.70269569
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69258407
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68630701
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.68609901
34* IGF1R_20145208_ChIP-Seq_DFB_Human1.64458352
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59696353
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.59526498
37ZNF274_21170338_ChIP-Seq_K562_Hela1.56865902
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51120645
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.51087857
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47204415
41* ELK1_19687146_ChIP-ChIP_HELA_Human1.46318786
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.44465661
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43512069
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43501267
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43263685
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41033455
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.40552068
48* TCF4_23295773_ChIP-Seq_U87_Human1.40469864
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38422068
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.35690748
51AR_25329375_ChIP-Seq_VCAP_Human1.34696614
52ER_23166858_ChIP-Seq_MCF-7_Human1.34348978
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32984750
54EWS_26573619_Chip-Seq_HEK293_Human1.32059938
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30105736
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.29518650
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.28085139
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27994650
59P300_19829295_ChIP-Seq_ESCs_Human1.27971032
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27285505
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26041499
62SOX9_26525672_Chip-Seq_HEART_Mouse1.25418140
63* STAT3_23295773_ChIP-Seq_U87_Human1.25223599
64* MYC_18940864_ChIP-ChIP_HL60_Human1.25100805
65BCAT_22108803_ChIP-Seq_LS180_Human1.23957907
66* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23798796
67RUNX2_22187159_ChIP-Seq_PCA_Human1.23436804
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22703674
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.22637966
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22599527
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.22254102
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.21887519
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21430013
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21309448
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21201232
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.20892372
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20811307
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.20589763
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.20566199
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19791178
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19756942
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.19156592
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18813001
84P53_22387025_ChIP-Seq_ESCs_Mouse1.18706554
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.17927966
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15414900
87KDM2B_26808549_Chip-Seq_REH_Human1.14462716
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14321328
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13793448
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13158203
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12782971
92IRF1_19129219_ChIP-ChIP_H3396_Human1.12356175
93* P300_18555785_Chip-Seq_ESCs_Mouse1.12338114
94WDR5_24793694_ChIP-Seq_LNCAP_Human1.12014994
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11756017
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11263538
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.11177552
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10633166
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10299329
100CBP_20019798_ChIP-Seq_JUKART_Human1.08989765
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08989765
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.08522073
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08140991
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08134246
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07218815
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06798649
107TP53_22573176_ChIP-Seq_HFKS_Human1.05188906
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05136702
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.05132951
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05039556
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04874524
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03950337
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.03312436
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.02831554
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.02674076
116TCF4_22108803_ChIP-Seq_LS180_Human1.02423278
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.02179894
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01318775
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01006306
120* TBL1_22424771_ChIP-Seq_293T_Human1.00725913
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00249074
122SOX2_18555785_Chip-Seq_ESCs_Mouse0.99824476
123NMYC_18555785_Chip-Seq_ESCs_Mouse0.99477017
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99449773
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.99433474
126AR_21572438_ChIP-Seq_LNCaP_Human0.99326309
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.96677272
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96260017
129CTCF_18555785_Chip-Seq_ESCs_Mouse0.94779521
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94504683
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93919882
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93265695
133NANOG_19829295_ChIP-Seq_ESCs_Human0.93091632
134SOX2_19829295_ChIP-Seq_ESCs_Human0.93091632
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92960460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.43217448
2MP0005410_abnormal_fertilization6.33417898
3MP0003698_abnormal_male_reproductive3.79617231
4MP0001929_abnormal_gametogenesis3.53396557
5MP0002210_abnormal_sex_determination3.23108558
6MP0003880_abnormal_central_pattern2.84026397
7MP0004859_abnormal_synaptic_plasticity2.81719866
8MP0001145_abnormal_male_reproductive2.55279969
9MP0002735_abnormal_chemical_nociception2.48549631
10MP0002653_abnormal_ependyma_morphology2.48281513
11MP0008057_abnormal_DNA_replication2.27183446
12MP0000653_abnormal_sex_gland2.25922216
13MP0006292_abnormal_olfactory_placode2.08227741
14MP0002161_abnormal_fertility/fecundity2.07853986
15MP0008995_early_reproductive_senescence2.06908546
16MP0002822_catalepsy2.04377618
17MP0009046_muscle_twitch1.93159854
18MP0002160_abnormal_reproductive_system1.92268108
19MP0003890_abnormal_embryonic-extraembry1.87365501
20MP0002938_white_spotting1.84780037
21MP0003635_abnormal_synaptic_transmissio1.80609056
22MP0000778_abnormal_nervous_system1.79251591
23MP0010094_abnormal_chromosome_stability1.78108945
24MP0003787_abnormal_imprinting1.76511632
25MP0001968_abnormal_touch/_nociception1.75206962
26MP0004133_heterotaxia1.74076876
27MP0002736_abnormal_nociception_after1.73375587
28MP0008058_abnormal_DNA_repair1.68996638
29MP0001529_abnormal_vocalization1.66998545
30MP0001188_hyperpigmentation1.63126936
31MP0000566_synostosis1.59666643
32MP0001440_abnormal_grooming_behavior1.56730636
33MP0002063_abnormal_learning/memory/cond1.56338975
34MP0001984_abnormal_olfaction1.55421260
35MP0009745_abnormal_behavioral_response1.53313186
36MP0002102_abnormal_ear_morphology1.49321169
37MP0002572_abnormal_emotion/affect_behav1.46338776
38MP0003937_abnormal_limbs/digits/tail_de1.45831332
39MP0002272_abnormal_nervous_system1.44780420
40MP0005551_abnormal_eye_electrophysiolog1.44368635
41MP0000049_abnormal_middle_ear1.44333016
42MP0003786_premature_aging1.41397597
43MP0005645_abnormal_hypothalamus_physiol1.39801739
44MP0001293_anophthalmia1.39763667
45MP0002233_abnormal_nose_morphology1.39493374
46MP0003119_abnormal_digestive_system1.35583352
47MP0001486_abnormal_startle_reflex1.35093958
48MP0002064_seizures1.34403642
49MP0003121_genomic_imprinting1.33509696
50MP0010030_abnormal_orbit_morphology1.33362611
51MP0004270_analgesia1.32394016
52MP0005253_abnormal_eye_physiology1.30877115
53MP0005248_abnormal_Harderian_gland1.29231207
54MP0003567_abnormal_fetal_cardiomyocyte1.27794101
55MP0004142_abnormal_muscle_tone1.27644373
56MP0003938_abnormal_ear_development1.27139793
57MP0001485_abnormal_pinna_reflex1.25647047
58MP0006276_abnormal_autonomic_nervous1.24847899
59MP0002751_abnormal_autonomic_nervous1.24103517
60MP0002876_abnormal_thyroid_physiology1.22949624
61MP0001986_abnormal_taste_sensitivity1.21739823
62MP0002557_abnormal_social/conspecific_i1.20072783
63MP0002734_abnormal_mechanical_nocicepti1.15920958
64MP0005389_reproductive_system_phenotype1.15897565
65MP0000955_abnormal_spinal_cord1.13744695
66MP0002184_abnormal_innervation1.13648938
67MP0002067_abnormal_sensory_capabilities1.10672024
68MP0004885_abnormal_endolymph1.10255243
69MP0003122_maternal_imprinting1.08203699
70MP0006072_abnormal_retinal_apoptosis1.08190558
71MP0005187_abnormal_penis_morphology1.07906663
72MP0008007_abnormal_cellular_replicative1.07196898
73MP0002638_abnormal_pupillary_reflex1.04529541
74MP0005647_abnormal_sex_gland1.03016728
75MP0003111_abnormal_nucleus_morphology1.02036226
76MP0002882_abnormal_neuron_morphology1.01908478
77MP0001286_abnormal_eye_development1.01843376
78MP0004742_abnormal_vestibular_system1.01716685
79MP0003878_abnormal_ear_physiology1.01004598
80MP0005377_hearing/vestibular/ear_phenot1.01004598
81MP0004215_abnormal_myocardial_fiber0.99336272
82MP0000372_irregular_coat_pigmentation0.98480862
83MP0002697_abnormal_eye_size0.98074228
84MP0004145_abnormal_muscle_electrophysio0.97856872
85MP0005171_absent_coat_pigmentation0.97626209
86MP0004811_abnormal_neuron_physiology0.97128269
87MP0005623_abnormal_meninges_morphology0.96346180
88MP0003861_abnormal_nervous_system0.95551472
89MP0002282_abnormal_trachea_morphology0.94923632
90MP0002152_abnormal_brain_morphology0.94721304
91MP0000647_abnormal_sebaceous_gland0.94082386
92MP0003879_abnormal_hair_cell0.91804215
93MP0001502_abnormal_circadian_rhythm0.91233831
94MP0003755_abnormal_palate_morphology0.90949896
95MP0002234_abnormal_pharynx_morphology0.89847223
96MP0002752_abnormal_somatic_nervous0.89664763
97MP0003123_paternal_imprinting0.87424488
98MP0001299_abnormal_eye_distance/0.85629611
99MP0003718_maternal_effect0.83912319
100MP0000631_abnormal_neuroendocrine_gland0.82509830
101MP0000569_abnormal_digit_pigmentation0.81500626
102MP0001119_abnormal_female_reproductive0.81149114
103MP0001324_abnormal_eye_pigmentation0.80921527
104MP0005499_abnormal_olfactory_system0.80541300
105MP0005394_taste/olfaction_phenotype0.80541300
106MP0003693_abnormal_embryo_hatching0.79493829
107MP0002229_neurodegeneration0.78799987
108MP0000015_abnormal_ear_pigmentation0.78081378
109MP0004147_increased_porphyrin_level0.77905988
110MP0002837_dystrophic_cardiac_calcinosis0.76794064
111MP0002733_abnormal_thermal_nociception0.75678952
112MP0002066_abnormal_motor_capabilities/c0.75353797
113MP0005386_behavior/neurological_phenoty0.73020435
114MP0004924_abnormal_behavior0.73020435
115MP0001963_abnormal_hearing_physiology0.72446401
116MP0003136_yellow_coat_color0.71910894
117MP0003183_abnormal_peptide_metabolism0.71287017
118MP0005195_abnormal_posterior_eye0.71163952
119MP0001970_abnormal_pain_threshold0.71068854
120MP0005409_darkened_coat_color0.69590316
121MP0004134_abnormal_chest_morphology0.68998230
122MP0005391_vision/eye_phenotype0.67754020
123MP0003011_delayed_dark_adaptation0.67411696
124MP0000026_abnormal_inner_ear0.67390124
125MP0003699_abnormal_female_reproductive0.66841981
126MP0008789_abnormal_olfactory_epithelium0.65633625
127MP0003077_abnormal_cell_cycle0.65330590
128MP0003646_muscle_fatigue0.64576373
129MP0000427_abnormal_hair_cycle0.63677674
130MP0003632_abnormal_nervous_system0.62978989
131MP0005423_abnormal_somatic_nervous0.61766091
132MP0001177_atelectasis0.59347564
133MP0005646_abnormal_pituitary_gland0.59089377

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.48637297
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.23561436
3Absent/shortened dynein arms (HP:0200106)8.23561436
4Abnormal respiratory motile cilium physiology (HP:0012261)5.77590622
5Abnormal respiratory motile cilium morphology (HP:0005938)5.63277299
6Abnormal respiratory epithelium morphology (HP:0012253)5.63277299
7Rhinitis (HP:0012384)4.71368916
8Abnormal ciliary motility (HP:0012262)4.67273660
9Nephronophthisis (HP:0000090)4.66289104
10Chronic bronchitis (HP:0004469)3.98558631
11Abnormality of the lower motor neuron (HP:0002366)3.85037206
12Infertility (HP:0000789)3.68524169
13Abnormality of the renal medulla (HP:0100957)3.43537892
14Medial flaring of the eyebrow (HP:0010747)3.42871123
15Tubulointerstitial nephritis (HP:0001970)3.33075636
16True hermaphroditism (HP:0010459)3.03741578
17Abnormal spermatogenesis (HP:0008669)3.00531877
18Molar tooth sign on MRI (HP:0002419)2.99355465
19Abnormality of midbrain morphology (HP:0002418)2.99355465
20Azoospermia (HP:0000027)2.99222520
21Chronic hepatic failure (HP:0100626)2.92806795
22Amyotrophic lateral sclerosis (HP:0007354)2.91026375
23Supernumerary spleens (HP:0009799)2.89096122
24Gait imbalance (HP:0002141)2.84960075
25Volvulus (HP:0002580)2.83925740
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70233963
27Oligodactyly (hands) (HP:0001180)2.65764545
28Pancreatic fibrosis (HP:0100732)2.65365095
29Congenital primary aphakia (HP:0007707)2.63783828
30Focal motor seizures (HP:0011153)2.61407432
31Nephroblastoma (Wilms tumor) (HP:0002667)2.55600143
32Oligodactyly (HP:0012165)2.55454374
33Chromsome breakage (HP:0040012)2.51574156
34Intestinal atresia (HP:0011100)2.51241443
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.50095571
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50095571
37Postaxial foot polydactyly (HP:0001830)2.48971047
38Gaze-evoked nystagmus (HP:0000640)2.42262081
39Impulsivity (HP:0100710)2.41604180
40Nephrogenic diabetes insipidus (HP:0009806)2.41475087
41Fibular hypoplasia (HP:0003038)2.40814780
42Embryonal renal neoplasm (HP:0011794)2.39765364
43Colon cancer (HP:0003003)2.39329766
44Bifid tongue (HP:0010297)2.36794843
45Bronchiectasis (HP:0002110)2.34656395
46Hyperventilation (HP:0002883)2.27537066
47Myokymia (HP:0002411)2.25092602
48Acute necrotizing encephalopathy (HP:0006965)2.24269709
49Vaginal atresia (HP:0000148)2.22722557
50Genital tract atresia (HP:0001827)2.22181277
51Poor coordination (HP:0002370)2.20593237
52* Gonadotropin excess (HP:0000837)2.19261962
53Upper motor neuron abnormality (HP:0002127)2.19081277
54Drooling (HP:0002307)2.15710208
55Pancreatic cysts (HP:0001737)2.15094458
56Abnormal biliary tract physiology (HP:0012439)2.12204533
57Bile duct proliferation (HP:0001408)2.12204533
58Broad foot (HP:0001769)2.11447136
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10947218
60Congenital hepatic fibrosis (HP:0002612)2.10030696
61Hyperglycinemia (HP:0002154)2.09194965
62Stage 5 chronic kidney disease (HP:0003774)2.08986107
63Rimmed vacuoles (HP:0003805)2.08759821
64Acute encephalopathy (HP:0006846)2.07510096
65Male pseudohermaphroditism (HP:0000037)2.07127133
66Tubular atrophy (HP:0000092)2.06111514
67Ectopic kidney (HP:0000086)2.05749023
68Abnormal hair whorl (HP:0010721)2.03780297
69Anophthalmia (HP:0000528)2.02302798
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.01953559
71Anencephaly (HP:0002323)2.01090817
72Abnormality of the renal cortex (HP:0011035)1.99440718
73Postaxial hand polydactyly (HP:0001162)1.99352879
74Limb dystonia (HP:0002451)1.98666078
75Nasal polyposis (HP:0100582)1.98203716
76Narrow forehead (HP:0000341)1.97780380
77Febrile seizures (HP:0002373)1.97277104
78Tubulointerstitial abnormality (HP:0001969)1.96982344
79Abnormality of the corticospinal tract (HP:0002492)1.96880032
80Progressive macrocephaly (HP:0004481)1.95675179
81Bronchitis (HP:0012387)1.95233206
82Cortical dysplasia (HP:0002539)1.95146758
83Renal hypoplasia (HP:0000089)1.95045400
8411 pairs of ribs (HP:0000878)1.94812547
85Renal dysplasia (HP:0000110)1.93766906
86Polyphagia (HP:0002591)1.92146139
87Absent septum pellucidum (HP:0001331)1.90003393
88Cystic liver disease (HP:0006706)1.88750554
89Excessive salivation (HP:0003781)1.88545018
90Male infertility (HP:0003251)1.88397004
91Decreased testicular size (HP:0008734)1.87984497
92Abnormal mitochondria in muscle tissue (HP:0008316)1.87141805
93Aplasia/Hypoplasia of the sternum (HP:0006714)1.85220968
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83815650
95Papillary thyroid carcinoma (HP:0002895)1.79645762
96Gastrointestinal atresia (HP:0002589)1.79301738
97Increased CSF lactate (HP:0002490)1.78798372
98Micropenis (HP:0000054)1.78585249
99Aplasia/Hypoplasia of the lens (HP:0008063)1.78468133
100Aganglionic megacolon (HP:0002251)1.78239016
101Preaxial hand polydactyly (HP:0001177)1.77167152
102Broad-based gait (HP:0002136)1.76631732
103Specific learning disability (HP:0001328)1.75191172
104Focal seizures (HP:0007359)1.74634742
105Triphalangeal thumb (HP:0001199)1.73729924
106Absent speech (HP:0001344)1.72700729
107Breast carcinoma (HP:0003002)1.71419735
108Optic nerve hypoplasia (HP:0000609)1.71054542
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.70766282
110Oculomotor apraxia (HP:0000657)1.70675544
111Abnormality of dentin (HP:0010299)1.70594409
112Abnormality of the labia minora (HP:0012880)1.70312433
113Multicystic kidney dysplasia (HP:0000003)1.70220802
114Epileptic encephalopathy (HP:0200134)1.70051465
115Progressive cerebellar ataxia (HP:0002073)1.69789889
116Abnormal lung lobation (HP:0002101)1.69638621
117Mitochondrial inheritance (HP:0001427)1.66480325
118Duplicated collecting system (HP:0000081)1.66112752
119Abnormality of alanine metabolism (HP:0010916)1.66044218
120Hyperalaninemia (HP:0003348)1.66044218
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66044218
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.65750037
123Hypothermia (HP:0002045)1.65447791
124Occipital encephalocele (HP:0002085)1.65172453
125Atonic seizures (HP:0010819)1.65145512
126Methylmalonic acidemia (HP:0002912)1.64868480
127Facial cleft (HP:0002006)1.64862666
128Recurrent sinusitis (HP:0011108)1.64716885
129Shoulder girdle muscle weakness (HP:0003547)1.64441851
130Septo-optic dysplasia (HP:0100842)1.63924834
131Prominent nasal bridge (HP:0000426)1.63477520
132Impaired vibration sensation in the lower limbs (HP:0002166)1.62515170
133Congenital stationary night blindness (HP:0007642)1.62018661
134Short tibia (HP:0005736)1.60260794
135Pachygyria (HP:0001302)1.60149424
136Astigmatism (HP:0000483)1.59039168
137Lissencephaly (HP:0001339)1.58878009
138Meckel diverticulum (HP:0002245)1.58711990
139Aplasia/Hypoplasia of the fibula (HP:0006492)1.58437719
140Abnormality of chromosome stability (HP:0003220)1.58376748
141Duodenal stenosis (HP:0100867)1.57670675
142Small intestinal stenosis (HP:0012848)1.57670675
143Median cleft lip (HP:0000161)1.57348745
144Capillary hemangiomas (HP:0005306)1.56965442
145Decreased motor nerve conduction velocity (HP:0003431)1.56339792
146Sloping forehead (HP:0000340)1.54914370
147Dysdiadochokinesis (HP:0002075)1.54114966
148Sclerocornea (HP:0000647)1.53606125
149Absent eyebrow (HP:0002223)1.52289963
150Cutaneous finger syndactyly (HP:0010554)1.50755454
151Abnormality of the ileum (HP:0001549)1.50517778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.55685268
2PDK45.55685268
3PRPF4B3.88964353
4PDK23.56116096
5EPHA43.29138124
6CASK3.03322881
7CDK192.84668253
8PRKD32.78036145
9TRIM282.72060971
10CDC72.64225138
11NTRK32.41210545
12MARK12.11060791
13MAP4K22.10975327
14FRK2.05959444
15NEK22.04157748
16BRD41.80945067
17PNCK1.80716557
18STK391.74382160
19NUAK11.61733812
20MAPK131.59939652
21EPHA31.57307890
22MAP3K41.56713566
23TNIK1.56598086
24ZAK1.53140345
25RPS6KA41.52439474
26KSR11.50494679
27ICK1.50203028
28WNK41.35265619
29SIK31.35205885
30VRK11.32776773
31CSNK1G21.26657749
32TESK11.25016040
33CSNK1G11.24538750
34MAP2K71.23786344
35MAP2K41.22283925
36BCR1.20214528
37BCKDK1.18349904
38ADRBK21.17883982
39PTK2B1.17551146
40ACVR1B1.15305444
41WNK31.14094930
42CSNK1G31.10641820
43CCNB11.06212742
44OBSCN1.04761108
45WNK11.03761027
46NTRK21.01649435
47BMPR1B0.95915872
48BRSK20.94813675
49SGK20.93351266
50SRPK10.91938210
51CDK30.90191789
52INSRR0.89416288
53TSSK60.88711672
54CSNK1A1L0.88617584
55PAK30.87839308
56MINK10.86555289
57EPHB20.86246082
58PLK40.86080497
59AKT30.84589833
60CHEK20.83632967
61FGFR20.82624009
62ATR0.82272349
63STK160.81577209
64CDK120.81390850
65SGK4940.81355401
66SGK2230.81355401
67TTK0.77669511
68PHKG20.77008948
69PHKG10.77008948
70DYRK30.76695566
71DYRK20.76010009
72PRKCG0.75520763
73CHEK10.75016389
74PRKCE0.73358464
75BRAF0.71708773
76YES10.69821361
77GRK10.67518374
78PLK10.63865445
79STK380.63676980
80MAPK150.62821842
81TYRO30.62317330
82PINK10.61076246
83LATS10.59330955
84DYRK1A0.59174013
85PLK20.58626175
86PRKD20.58277263
87ATM0.56987765
88PLK30.55701392
89ERBB30.54637466
90DYRK1B0.51054419
91BRSK10.50817294
92NEK60.50204974
93PAK60.49929658
94MAP3K90.49560862
95BUB10.49495579
96VRK20.49252090
97CAMK2A0.48902411
98PIK3CA0.48657561
99RPS6KA50.48638112
100TGFBR10.48015738
101MAP3K60.46573707
102TAOK20.46239623
103CDC42BPA0.45389809
104CAMK10.45129223
105CAMK40.42242676
106FGFR10.41908166
107MAPK100.41178485
108PKN10.40638044
109CDK10.40393107
110CAMK1G0.39459949
111CAMKK20.39433899
112PRKACB0.38944532
113SGK30.38237262
114GSK3B0.37681256
115MKNK20.37303481
116SGK10.36953423
117CSNK1A10.36695783
118CDK50.36313003
119PRKACA0.36170132
120STK38L0.35923248
121OXSR10.35894948
122ERBB20.35147622
123PRKDC0.34896485
124TIE10.34740283
125UHMK10.34516262
126WEE10.33987056
127CDK180.33714773
128LMTK20.32975293
129MKNK10.31822458
130CAMK2B0.31126957
131NEK10.30545821
132PASK0.29971484
133CDK20.29512952
134PRKCZ0.29433368
135STK110.27994626
136STK30.27907645
137RPS6KA30.27111786
138EIF2AK20.26684021

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66740844
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14581674
3Fanconi anemia pathway_Homo sapiens_hsa034603.11435178
4Protein export_Homo sapiens_hsa030602.88556578
5Amphetamine addiction_Homo sapiens_hsa050312.36050539
6Basal transcription factors_Homo sapiens_hsa030222.35596149
7Oxidative phosphorylation_Homo sapiens_hsa001902.34650086
8Glutamatergic synapse_Homo sapiens_hsa047242.31478336
9Oocyte meiosis_Homo sapiens_hsa041142.30924081
10mRNA surveillance pathway_Homo sapiens_hsa030152.27496639
11Long-term potentiation_Homo sapiens_hsa047202.27169762
12Non-homologous end-joining_Homo sapiens_hsa034502.24771511
13Parkinsons disease_Homo sapiens_hsa050122.23446775
14Morphine addiction_Homo sapiens_hsa050322.18137380
15Olfactory transduction_Homo sapiens_hsa047402.17524631
16Dorso-ventral axis formation_Homo sapiens_hsa043202.15071224
17Butanoate metabolism_Homo sapiens_hsa006502.09768073
18Steroid biosynthesis_Homo sapiens_hsa001002.05367436
19Taste transduction_Homo sapiens_hsa047421.90849960
20Synaptic vesicle cycle_Homo sapiens_hsa047211.83320297
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80322694
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72180293
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68396751
24Axon guidance_Homo sapiens_hsa043601.64450669
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63520986
26Renin secretion_Homo sapiens_hsa049241.62987836
27Circadian entrainment_Homo sapiens_hsa047131.62571445
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54438576
29Glucagon signaling pathway_Homo sapiens_hsa049221.52698734
30Homologous recombination_Homo sapiens_hsa034401.50176114
31Pyruvate metabolism_Homo sapiens_hsa006201.48003100
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46615437
33Vitamin B6 metabolism_Homo sapiens_hsa007501.44025595
34Calcium signaling pathway_Homo sapiens_hsa040201.43848995
35Fatty acid elongation_Homo sapiens_hsa000621.41325630
36Serotonergic synapse_Homo sapiens_hsa047261.40065703
37GABAergic synapse_Homo sapiens_hsa047271.40013893
38Dopaminergic synapse_Homo sapiens_hsa047281.39485911
39Cell cycle_Homo sapiens_hsa041101.38426501
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37939246
41Phototransduction_Homo sapiens_hsa047441.35409562
42RNA polymerase_Homo sapiens_hsa030201.31882443
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.29236949
44Ether lipid metabolism_Homo sapiens_hsa005651.28229674
45RNA transport_Homo sapiens_hsa030131.28007334
46Spliceosome_Homo sapiens_hsa030401.26327583
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21199504
48Alzheimers disease_Homo sapiens_hsa050101.17351336
49Proteasome_Homo sapiens_hsa030501.11409937
50Mismatch repair_Homo sapiens_hsa034301.09328108
51RNA degradation_Homo sapiens_hsa030181.05697281
52Ribosome_Homo sapiens_hsa030101.05471136
53Cocaine addiction_Homo sapiens_hsa050301.05168254
54Insulin secretion_Homo sapiens_hsa049111.04387526
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03088469
56Oxytocin signaling pathway_Homo sapiens_hsa049211.03061071
57beta-Alanine metabolism_Homo sapiens_hsa004100.98399984
58Wnt signaling pathway_Homo sapiens_hsa043100.98189136
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97508315
60Huntingtons disease_Homo sapiens_hsa050160.96800907
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95082356
62Purine metabolism_Homo sapiens_hsa002300.93616826
63Linoleic acid metabolism_Homo sapiens_hsa005910.93520985
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91267604
65Folate biosynthesis_Homo sapiens_hsa007900.89394670
66Hedgehog signaling pathway_Homo sapiens_hsa043400.88992178
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88049800
68Cholinergic synapse_Homo sapiens_hsa047250.87961208
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86880848
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86672221
71Tryptophan metabolism_Homo sapiens_hsa003800.86121561
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86109450
73cAMP signaling pathway_Homo sapiens_hsa040240.85633259
74Alcoholism_Homo sapiens_hsa050340.85551371
75Regulation of autophagy_Homo sapiens_hsa041400.83993854
76Salivary secretion_Homo sapiens_hsa049700.82557192
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82350793
78Cardiac muscle contraction_Homo sapiens_hsa042600.81637551
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81024172
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80106903
81Peroxisome_Homo sapiens_hsa041460.79555952
82Circadian rhythm_Homo sapiens_hsa047100.76941495
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.76235995
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.74970717
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74749990
86Gastric acid secretion_Homo sapiens_hsa049710.74636106
87ErbB signaling pathway_Homo sapiens_hsa040120.72916794
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72836877
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71977271
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71184183
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71015071
92Pyrimidine metabolism_Homo sapiens_hsa002400.70343660
93Collecting duct acid secretion_Homo sapiens_hsa049660.69809239
94Nucleotide excision repair_Homo sapiens_hsa034200.69020502
95Fatty acid metabolism_Homo sapiens_hsa012120.69016547
96Sulfur relay system_Homo sapiens_hsa041220.68892695
97Long-term depression_Homo sapiens_hsa047300.68829570
98Hippo signaling pathway_Homo sapiens_hsa043900.68725769
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.67083926
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65456402
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64399544
102Metabolic pathways_Homo sapiens_hsa011000.62202454
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62014230
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60328530
105Fatty acid biosynthesis_Homo sapiens_hsa000610.60116819
106Fatty acid degradation_Homo sapiens_hsa000710.59871575
107Basal cell carcinoma_Homo sapiens_hsa052170.59651992
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58714111
109Estrogen signaling pathway_Homo sapiens_hsa049150.58569391
110Type II diabetes mellitus_Homo sapiens_hsa049300.57437319
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56887131
112Nitrogen metabolism_Homo sapiens_hsa009100.55522069
113MAPK signaling pathway_Homo sapiens_hsa040100.54870642
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54288138
115Glycerolipid metabolism_Homo sapiens_hsa005610.54275342
116Mineral absorption_Homo sapiens_hsa049780.53453729
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.52921079
118TGF-beta signaling pathway_Homo sapiens_hsa043500.52299150
119Ras signaling pathway_Homo sapiens_hsa040140.52282969
120Retinol metabolism_Homo sapiens_hsa008300.50709203
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48359866
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48265263
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.47642442
124VEGF signaling pathway_Homo sapiens_hsa043700.46323459
125Choline metabolism in cancer_Homo sapiens_hsa052310.45887904
126Lysine degradation_Homo sapiens_hsa003100.45007454
127Inositol phosphate metabolism_Homo sapiens_hsa005620.44865069
128Gap junction_Homo sapiens_hsa045400.44813496
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44084722
130Melanogenesis_Homo sapiens_hsa049160.42889502
131Ovarian steroidogenesis_Homo sapiens_hsa049130.42755445
132Base excision repair_Homo sapiens_hsa034100.42090846
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.41946388
134Colorectal cancer_Homo sapiens_hsa052100.41485895
135Systemic lupus erythematosus_Homo sapiens_hsa053220.39894084
136Chemical carcinogenesis_Homo sapiens_hsa052040.39701267
137DNA replication_Homo sapiens_hsa030300.39159073
138Glutathione metabolism_Homo sapiens_hsa004800.38706133
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38388397
140N-Glycan biosynthesis_Homo sapiens_hsa005100.37876478
141Caffeine metabolism_Homo sapiens_hsa002320.37283853
142Endometrial cancer_Homo sapiens_hsa052130.37176284
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37050007
144Selenocompound metabolism_Homo sapiens_hsa004500.36582677
145p53 signaling pathway_Homo sapiens_hsa041150.34135417
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33574616
147Pancreatic secretion_Homo sapiens_hsa049720.32440662
148Sphingolipid metabolism_Homo sapiens_hsa006000.32322377
149Propanoate metabolism_Homo sapiens_hsa006400.31366949

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