HGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.39164813
2complement activation, alternative pathway (GO:0006957)4.42014113
3positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.29993814
4negative regulation of smooth muscle cell migration (GO:0014912)4.27386024
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.25240188
6regulation of protein activation cascade (GO:2000257)4.14810348
7extracellular matrix assembly (GO:0085029)4.14009190
8protein heterotrimerization (GO:0070208)4.08823115
9peptidyl-glutamic acid carboxylation (GO:0017187)4.04796431
10protein carboxylation (GO:0018214)4.04796431
11regulation of complement activation (GO:0030449)3.96849995
12alpha-linolenic acid metabolic process (GO:0036109)3.88952069
13negative regulation of fibrinolysis (GO:0051918)3.88906756
14low-density lipoprotein particle remodeling (GO:0034374)3.85860524
15endodermal cell differentiation (GO:0035987)3.83676815
16bile acid biosynthetic process (GO:0006699)3.74996210
17L-phenylalanine catabolic process (GO:0006559)3.72767916
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72767916
19sequestering of extracellular ligand from receptor (GO:0035581)3.71463236
20high-density lipoprotein particle remodeling (GO:0034375)3.69899300
21regulation of fibrinolysis (GO:0051917)3.68780937
22aromatic amino acid family catabolic process (GO:0009074)3.67916490
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61472511
24collagen fibril organization (GO:0030199)3.60833372
25urea metabolic process (GO:0019627)3.58649206
26urea cycle (GO:0000050)3.58649206
27hypotonic response (GO:0006971)3.57856959
28plasma lipoprotein particle remodeling (GO:0034369)3.56123805
29protein-lipid complex remodeling (GO:0034368)3.56123805
30macromolecular complex remodeling (GO:0034367)3.56123805
31indole-containing compound catabolic process (GO:0042436)3.54673456
32indolalkylamine catabolic process (GO:0046218)3.54673456
33tryptophan catabolic process (GO:0006569)3.54673456
34phospholipid efflux (GO:0033700)3.53678388
35pinocytosis (GO:0006907)3.50186264
36regulation of macrophage cytokine production (GO:0010935)3.50070161
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.48681571
38positive regulation by symbiont of host defense response (GO:0052509)3.46970761
39modulation by symbiont of host defense response (GO:0052031)3.46970761
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46970761
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46970761
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.46970761
43modulation by symbiont of host immune response (GO:0052553)3.46970761
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44473030
45L-phenylalanine metabolic process (GO:0006558)3.44473030
46reverse cholesterol transport (GO:0043691)3.43609221
47type B pancreatic cell proliferation (GO:0044342)3.42169810
48collagen metabolic process (GO:0032963)3.40040992
49skin morphogenesis (GO:0043589)3.39778135
50regulation of interferon-beta biosynthetic process (GO:0045357)3.39729636
51tryptophan metabolic process (GO:0006568)3.38978971
52blood vessel maturation (GO:0001955)3.38433829
53apoptotic cell clearance (GO:0043277)3.37638008
54definitive hemopoiesis (GO:0060216)3.36493439
55bone trabecula formation (GO:0060346)3.33931233
56regulation of cholesterol esterification (GO:0010872)3.33890914
57lung vasculature development (GO:0060426)3.31849742
58collagen catabolic process (GO:0030574)3.30909509
59phospholipid homeostasis (GO:0055091)3.27948303
60plasma lipoprotein particle clearance (GO:0034381)3.27925702
61production of molecular mediator involved in inflammatory response (GO:0002532)3.27526871
62chondroitin sulfate biosynthetic process (GO:0030206)3.27234135
63regulation of response to osmotic stress (GO:0047484)3.24388975
64extracellular fibril organization (GO:0043206)3.21788499
65nitrogen cycle metabolic process (GO:0071941)3.21725031
66cell migration involved in heart development (GO:0060973)3.21442885
67positive regulation of blood coagulation (GO:0030194)3.20199363
68positive regulation of hemostasis (GO:1900048)3.20199363
69regulation of triglyceride catabolic process (GO:0010896)3.20019286
70adhesion of symbiont to host cell (GO:0044650)3.19758061
71virion attachment to host cell (GO:0019062)3.19758061
72sulfur amino acid catabolic process (GO:0000098)3.19510039
73keratan sulfate catabolic process (GO:0042340)3.18477664
74kynurenine metabolic process (GO:0070189)3.17727728
75positive regulation of macrophage cytokine production (GO:0060907)3.16253626
76plasma lipoprotein particle assembly (GO:0034377)3.15940452
77fibril organization (GO:0097435)3.15874159
78glyoxylate metabolic process (GO:0046487)3.13742079
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.12431968
80acute-phase response (GO:0006953)3.12029999
81positive regulation of coagulation (GO:0050820)3.11536125
82opsonization (GO:0008228)3.11506300
83response to interferon-beta (GO:0035456)3.11056220
84positive regulation of B cell differentiation (GO:0045579)3.10771186
85basement membrane organization (GO:0071711)3.10749445
86multicellular organismal macromolecule metabolic process (GO:0044259)3.10475906
87bile acid metabolic process (GO:0008206)3.08677400
88adhesion of symbiont to host (GO:0044406)3.08117246
89fibrinolysis (GO:0042730)3.07553692
90chondrocyte proliferation (GO:0035988)3.06330799
91negative regulation of biomineral tissue development (GO:0070168)3.05636217
92cholesterol efflux (GO:0033344)3.04982397
93regulation of smooth muscle cell migration (GO:0014910)3.04858549
94plasma lipoprotein particle organization (GO:0071827)3.02918237
95cell adhesion mediated by integrin (GO:0033627)3.00827934
96blood coagulation, intrinsic pathway (GO:0007597)2.99205561
97aldehyde catabolic process (GO:0046185)2.99198707
98neutrophil activation involved in immune response (GO:0002283)2.99039386
99myeloid leukocyte mediated immunity (GO:0002444)2.98940842
100very-low-density lipoprotein particle assembly (GO:0034379)2.98811578
101multicellular organismal catabolic process (GO:0044243)2.97868906
102hyaluronan catabolic process (GO:0030214)2.97702418
103homocysteine metabolic process (GO:0050667)2.96468891
104negative regulation of fatty acid transport (GO:2000192)2.95382884
105protein activation cascade (GO:0072376)2.95094293
106response to peptidoglycan (GO:0032494)2.94499104
107imidazole-containing compound metabolic process (GO:0052803)2.93969386
108negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.93896090
109modulation of growth of symbiont involved in interaction with host (GO:0044144)2.93896090
110regulation of growth of symbiont in host (GO:0044126)2.93896090
111negative regulation of growth of symbiont in host (GO:0044130)2.93896090
112mannose metabolic process (GO:0006013)2.93604488
113regulation of humoral immune response (GO:0002920)2.92624234
114positive regulation of lipid catabolic process (GO:0050996)2.92312782
115* mesenchymal-epithelial cell signaling (GO:0060638)2.91536801
116multicellular organismal metabolic process (GO:0044236)2.91524010
117cortical actin cytoskeleton organization (GO:0030866)2.91199625
118protein-lipid complex assembly (GO:0065005)2.90722735
119response to interferon-alpha (GO:0035455)2.89625941
120protein-lipid complex subunit organization (GO:0071825)2.89115834
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87025049
122extracellular matrix disassembly (GO:0022617)2.85304845
123neutrophil mediated immunity (GO:0002446)2.84737545
124regulation of apoptotic cell clearance (GO:2000425)2.83486829
125immunoglobulin mediated immune response (GO:0016064)2.83348821
126regulation of chemokine biosynthetic process (GO:0045073)2.83225393
127cysteine metabolic process (GO:0006534)2.83092781
128regulation of heterotypic cell-cell adhesion (GO:0034114)2.81691920
129complement activation (GO:0006956)2.81313723
130positive regulation of extracellular matrix organization (GO:1903055)2.81047561
131positive regulation of phagocytosis (GO:0050766)2.80921516
132lipoprotein metabolic process (GO:0042157)2.80740597
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.79943379
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79288573
135detection of molecule of bacterial origin (GO:0032490)2.78207672
136NAD biosynthetic process (GO:0009435)2.76986529
137phagocytosis, engulfment (GO:0006911)2.76795348
138response to muramyl dipeptide (GO:0032495)2.76293643
139positive regulation of interferon-alpha production (GO:0032727)2.76117780
140microglial cell activation (GO:0001774)2.75296767
141cellular response to vitamin (GO:0071295)2.74370230
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73660121
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73660121
144UV protection (GO:0009650)2.73230558
145mature B cell differentiation involved in immune response (GO:0002313)2.71921609
146killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.71542566
147disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.71542566
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67672723
149respiratory tube development (GO:0030323)2.66943401
150platelet dense granule organization (GO:0060155)2.66888641
151cellular glucuronidation (GO:0052695)2.66768405
152negative regulation of cholesterol transport (GO:0032375)2.65625428
153negative regulation of sterol transport (GO:0032372)2.65625428
154mesodermal cell differentiation (GO:0048333)2.65230097
155nicotinamide nucleotide biosynthetic process (GO:0019359)2.64613597
156pyridine nucleotide biosynthetic process (GO:0019363)2.64613597
157positive regulation of smooth muscle cell migration (GO:0014911)2.64321825
158amino-acid betaine metabolic process (GO:0006577)2.63366232
159macrophage activation involved in immune response (GO:0002281)2.62428137
160bile acid and bile salt transport (GO:0015721)2.61976124
161detection of external biotic stimulus (GO:0098581)2.61707021
162cellular extravasation (GO:0045123)2.61569756
163regulation of leukocyte degranulation (GO:0043300)2.60153802
164vascular endothelial growth factor signaling pathway (GO:0038084)2.59631913
165positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.56606563
166negative regulation of interleukin-8 production (GO:0032717)2.56476369
167phagocytosis, recognition (GO:0006910)2.55460258
168positive regulation of Rho protein signal transduction (GO:0035025)2.54405472
169tooth mineralization (GO:0034505)2.54313239
170cortical cytoskeleton organization (GO:0030865)2.51781389
171glial cell migration (GO:0008347)2.51117357
172lung lobe morphogenesis (GO:0060463)2.50684002
173regulation of phagocytosis (GO:0050764)2.49404814
174substrate-dependent cell migration (GO:0006929)2.48848848
175dermatan sulfate metabolic process (GO:0030205)2.47534998
176dermatan sulfate biosynthetic process (GO:0030208)2.47369327
177regulation of mast cell degranulation (GO:0043304)2.45710591
178positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.45099659
179interleukin-1-mediated signaling pathway (GO:0070498)2.41810212
180negative regulation of erythrocyte differentiation (GO:0045647)2.40630677
181barbed-end actin filament capping (GO:0051016)2.39855707
182positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39773337
183positive regulation of osteoblast proliferation (GO:0033690)2.39583141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.73760961
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.10562486
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.06781677
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.77003387
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.55090528
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00460849
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.90936527
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.73300050
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.36670171
10SCL_19346495_ChIP-Seq_HPC-7_Human3.28461296
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11697487
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05425431
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.02650180
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02246721
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83478928
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83140244
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82502101
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82261004
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78074911
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76831012
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70027268
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61131981
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.58220605
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24501581
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.21699847
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20255688
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.08055639
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07869123
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07448758
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05256695
31* BRD4_25478319_ChIP-Seq_HGPS_Human2.04469064
32GATA1_22025678_ChIP-Seq_K562_Human2.02643393
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01362369
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97115764
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97048480
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93184610
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.84521545
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82949184
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82890124
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.80633405
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78567014
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.73029691
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66847699
44* SPI1_23547873_ChIP-Seq_NB4_Human1.64602764
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63251020
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59382753
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.57815237
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54553889
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53113807
50* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49731666
51* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48888190
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43558150
53PU_27001747_Chip-Seq_BMDM_Mouse1.42579121
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41829453
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41828335
56VDR_24763502_ChIP-Seq_THP-1_Human1.37612233
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37573252
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37468971
59* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37461608
60RUNX_20019798_ChIP-Seq_JUKART_Human1.36775570
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36748395
62LXR_22292898_ChIP-Seq_THP-1_Human1.36477018
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35050193
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33396724
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30762769
66MYC_22102868_ChIP-Seq_BL_Human1.29334211
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28357910
68TCF7_22412390_ChIP-Seq_EML_Mouse1.28319038
69SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27815372
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26792036
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25542259
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.24820255
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24510621
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24252293
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23795806
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23541123
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23405765
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22928751
79TP53_22127205_ChIP-Seq_IMR90_Human1.19598137
80VDR_24787735_ChIP-Seq_THP-1_Human1.19386498
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.17231771
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15251756
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14503631
84* MYB_26560356_Chip-Seq_TH2_Human1.14404243
85KDM2B_26808549_Chip-Seq_DND41_Human1.12514862
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12247660
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12247660
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12027831
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10358610
90* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10221783
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09675883
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09387325
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09311617
94MYB_26560356_Chip-Seq_TH1_Human1.08340535
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08322569
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07698426
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06996843
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.04742810
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.04742810
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04670137
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04227296
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03767512
103* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02955726
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01563794
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.01105955
106UTX_26944678_Chip-Seq_JUKART_Human1.00883197
107SPI1_23127762_ChIP-Seq_K562_Human1.00831783
108CLOCK_20551151_ChIP-Seq_293T_Human0.99878871
109* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99810865
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97673962
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97248602
112VDR_21846776_ChIP-Seq_THP-1_Human0.96098152
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95517548
114* TP53_16413492_ChIP-PET_HCT116_Human0.94496337
115* TP53_18474530_ChIP-ChIP_U2OS_Human0.93929737
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92036394
117HTT_18923047_ChIP-ChIP_STHdh_Human0.91895871
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.91633741
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91616095
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89029347
121MAF_26560356_Chip-Seq_TH1_Human0.86958035
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86929626
123GATA2_19941826_ChIP-Seq_K562_Human0.84132552
124GATA3_26560356_Chip-Seq_TH2_Human0.83684008
125* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82868870
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81104416
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.81031664
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80906509
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80492841
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78020507
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77611800
132CJUN_26792858_Chip-Seq_BT549_Human0.76943530
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76905721
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74651272
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.74621103
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73502614
137SOX2_20726797_ChIP-Seq_SW620_Human0.70746484
138GATA3_27048872_Chip-Seq_THYMUS_Human0.68091272
139HNF4A_19822575_ChIP-Seq_HepG2_Human0.67904000
140GATA1_19941826_ChIP-Seq_K562_Human0.66312000
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65866966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.22062918
2MP0005360_urolithiasis3.89369801
3MP0005365_abnormal_bile_salt3.42409326
4MP0005085_abnormal_gallbladder_physiolo3.24707686
5MP0003436_decreased_susceptibility_to2.96854197
6MP0008438_abnormal_cutaneous_collagen2.83645488
7MP0009840_abnormal_foam_cell2.80333312
8MP0001835_abnormal_antigen_presentation2.62751390
9MP0003252_abnormal_bile_duct2.58461743
10MP0003724_increased_susceptibility_to2.56352416
11MP0005464_abnormal_platelet_physiology2.39746268
12MP0008875_abnormal_xenobiotic_pharmacok2.36851365
13MP0009785_altered_susceptibility_to2.33681230
14MP0003191_abnormal_cellular_cholesterol2.30359241
15MP0010329_abnormal_lipoprotein_level2.28641123
16MP0002419_abnormal_innate_immunity2.25135678
17MP0001542_abnormal_bone_strength2.23482122
18MP0005058_abnormal_lysosome_morphology2.09052192
19MP0004272_abnormal_basement_membrane2.07697895
20MP0005083_abnormal_biliary_tract1.97683549
21MP0002148_abnormal_hypersensitivity_rea1.91168815
22MP0005025_abnormal_response_to1.90606134
23MP0006082_CNS_inflammation1.84948803
24MP0009764_decreased_sensitivity_to1.84021614
25MP0003279_aneurysm1.80339062
26MP0003806_abnormal_nucleotide_metabolis1.78345650
27MP0002396_abnormal_hematopoietic_system1.75882854
28MP0005000_abnormal_immune_tolerance1.65982874
29MP0003091_abnormal_cell_migration1.63286088
30MP0003195_calcinosis1.61700858
31MP0001533_abnormal_skeleton_physiology1.58699422
32MP0000685_abnormal_immune_system1.58552421
33MP0008469_abnormal_protein_level1.56853367
34MP0003566_abnormal_cell_adhesion1.56358995
35MP0003172_abnormal_lysosome_physiology1.54203140
36MP0001853_heart_inflammation1.54120220
37MP0001545_abnormal_hematopoietic_system1.53775469
38MP0005397_hematopoietic_system_phenotyp1.53775469
39MP0003303_peritoneal_inflammation1.51622826
40MP0001986_abnormal_taste_sensitivity1.51428542
41MP0005257_abnormal_intraocular_pressure1.49085103
42* MP0000609_abnormal_liver_physiology1.47915610
43MP0005508_abnormal_skeleton_morphology1.46791687
44MP0003868_abnormal_feces_composition1.45662869
45MP0003705_abnormal_hypodermis_morpholog1.45036465
46MP0006054_spinal_hemorrhage1.44923816
47MP0003300_gastrointestinal_ulcer1.44125136
48MP0000569_abnormal_digit_pigmentation1.42692039
49MP0009278_abnormal_bone_marrow1.42619473
50MP0009697_abnormal_copulation1.41493999
51MP0002452_abnormal_antigen_presenting1.40014375
52MP0003448_altered_tumor_morphology1.38666007
53MP0002254_reproductive_system_inflammat1.36414340
54MP0000465_gastrointestinal_hemorrhage1.36156251
55MP0005171_absent_coat_pigmentation1.36041261
56MP0002877_abnormal_melanocyte_morpholog1.35694089
57MP0009763_increased_sensitivity_to1.33777923
58MP0002166_altered_tumor_susceptibility1.33048312
59MP0002723_abnormal_immune_serum1.32000748
60MP0001800_abnormal_humoral_immune1.31085108
61MP0002295_abnormal_pulmonary_circulatio1.31077695
62MP0003075_altered_response_to1.30587729
63MP0000343_altered_response_to1.29833320
64MP0005332_abnormal_amino_acid1.29830663
65MP0001666_abnormal_nutrient_absorption1.28488952
66MP0005319_abnormal_enzyme/_coenzyme1.27205860
67MP0001845_abnormal_inflammatory_respons1.26302434
68MP0004883_abnormal_blood_vessel1.25494777
69MP0000858_altered_metastatic_potential1.25478183
70MP0004808_abnormal_hematopoietic_stem1.21593738
71MP0002118_abnormal_lipid_homeostasis1.20246800
72MP0002006_tumorigenesis1.19469675
73MP0005275_abnormal_skin_tensile1.16690480
74MP0005076_abnormal_cell_differentiation1.15416055
75MP0003950_abnormal_plasma_membrane1.15399097
76MP0001819_abnormal_immune_cell1.13598659
77MP0002420_abnormal_adaptive_immunity1.13231249
78MP0000767_abnormal_smooth_muscle1.12712885
79MP0000598_abnormal_liver_morphology1.12676042
80MP0000751_myopathy1.12616971
81MP0005671_abnormal_response_to1.12504114
82MP0002009_preneoplasia1.12011235
83MP0003690_abnormal_glial_cell1.11504405
84MP0003656_abnormal_erythrocyte_physiolo1.10759923
85MP0010155_abnormal_intestine_physiology1.08503902
86MP0001790_abnormal_immune_system1.08272216
87MP0005387_immune_system_phenotype1.08272216
88MP0003186_abnormal_redox_activity1.07291932
89MP0002896_abnormal_bone_mineralization1.06923032
90MP0005023_abnormal_wound_healing1.06904987
91MP0005595_abnormal_vascular_smooth1.06828397
92MP0001958_emphysema1.06317783
93MP0002108_abnormal_muscle_morphology1.06300735
94MP0009384_cardiac_valve_regurgitation1.04491803
95MP0005174_abnormal_tail_pigmentation1.02810512
96MP0002998_abnormal_bone_remodeling1.01339132
97MP0010386_abnormal_urinary_bladder1.00246886
98MP0001243_abnormal_dermal_layer1.00011166
99MP0010368_abnormal_lymphatic_system0.99976249
100MP0002405_respiratory_system_inflammati0.97552008
101MP0004947_skin_inflammation0.96676981
102MP0004019_abnormal_vitamin_homeostasis0.96155801
103MP0001764_abnormal_homeostasis0.95660850
104MP0005623_abnormal_meninges_morphology0.94582938
105MP0005166_decreased_susceptibility_to0.94101405
106MP0005390_skeleton_phenotype0.91420882
107MP0000604_amyloidosis0.91351919
108MP0003795_abnormal_bone_structure0.90642310
109MP0002060_abnormal_skin_morphology0.89895641
110MP0005584_abnormal_enzyme/coenzyme_acti0.89398587
111MP0003828_pulmonary_edema0.88821688
112MP0002168_other_aberrant_phenotype0.86950663
113MP0000689_abnormal_spleen_morphology0.86511613
114MP0000733_abnormal_muscle_development0.86472194
115MP0008004_abnormal_stomach_pH0.86431350
116MP0005164_abnormal_response_to0.85962403
117MP0000716_abnormal_immune_system0.85420901
118MP0003045_fibrosis0.84915157
119MP0005503_abnormal_tendon_morphology0.84770868
120MP0002398_abnormal_bone_marrow0.81099303
121MP0001915_intracranial_hemorrhage0.80596864
122MP0000249_abnormal_blood_vessel0.80592690
123MP0002933_joint_inflammation0.80110428
124MP0003011_delayed_dark_adaptation0.78256227
125MP0009765_abnormal_xenobiotic_induced0.78179134
126MP0001661_extended_life_span0.77409247
127MP0008874_decreased_physiological_sensi0.76504266
128MP0010352_gastrointestinal_tract_polyps0.75920709
129MP0003943_abnormal_hepatobiliary_system0.75847941
130* MP0002429_abnormal_blood_cell0.75036754
131MP0005165_increased_susceptibility_to0.72048735
132MP0004130_abnormal_muscle_cell0.71917051
133MP0005220_abnormal_exocrine_pancreas0.71675921
134MP0009643_abnormal_urine_homeostasis0.71354874
135MP0003763_abnormal_thymus_physiology0.69980169
136MP0004134_abnormal_chest_morphology0.69881131
137MP0000681_abnormal_thyroid_gland0.68139443
138MP0005451_abnormal_body_composition0.65645667

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)4.79757575
2Deep venous thrombosis (HP:0002625)4.73894523
3Follicular hyperkeratosis (HP:0007502)4.72929833
4Aortic aneurysm (HP:0004942)4.67166973
5Aortic dissection (HP:0002647)4.61073761
6Joint hemorrhage (HP:0005261)4.60693893
7Recurrent gram-negative bacterial infections (HP:0005420)4.59920268
8Complement deficiency (HP:0004431)4.59583582
9Prolonged partial thromboplastin time (HP:0003645)4.34945330
10Intrahepatic cholestasis (HP:0001406)4.32213479
11Spondylolisthesis (HP:0003302)4.26505883
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24798602
13Systemic lupus erythematosus (HP:0002725)4.22857524
14Xanthomatosis (HP:0000991)4.18707587
15Type 1 muscle fiber predominance (HP:0003803)4.16559973
16Soft skin (HP:0000977)3.89652386
17Vascular tortuosity (HP:0004948)3.89309307
18Slender build (HP:0001533)3.87588714
19Abnormality of complement system (HP:0005339)3.81803554
20Recurrent bacterial skin infections (HP:0005406)3.76935312
21Recurrent abscess formation (HP:0002722)3.67117789
22Abnormality of the common coagulation pathway (HP:0010990)3.65486421
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.64680956
24Gingival bleeding (HP:0000225)3.63666572
25Arterial tortuosity (HP:0005116)3.62183172
26Wormian bones (HP:0002645)3.56428905
27Hypobetalipoproteinemia (HP:0003563)3.53767415
28Hyperlipoproteinemia (HP:0010980)3.41874471
29Eczematoid dermatitis (HP:0000976)3.38721841
30Glomerulonephritis (HP:0000099)3.23788735
31Bladder diverticulum (HP:0000015)3.19203238
32Spontaneous hematomas (HP:0007420)3.15543114
33Myocardial infarction (HP:0001658)3.14191543
34Increased variability in muscle fiber diameter (HP:0003557)3.14025126
35Genu recurvatum (HP:0002816)3.05466749
36Absent frontal sinuses (HP:0002688)3.04918114
37Epidermoid cyst (HP:0200040)3.04776576
38Epistaxis (HP:0000421)3.03085203
39Spinal rigidity (HP:0003306)2.98423481
40Dilatation of the ascending aorta (HP:0005111)2.97539129
41Broad metatarsal (HP:0001783)2.95809534
42Cerebral aneurysm (HP:0004944)2.93958307
43Hypercholesterolemia (HP:0003124)2.93257360
44Delayed closure of the anterior fontanelle (HP:0001476)2.93044796
45Hypolipoproteinemia (HP:0010981)2.92758726
46Abnormality of dentin (HP:0010299)2.89758776
47Blue sclerae (HP:0000592)2.89472465
48Overgrowth (HP:0001548)2.89130877
49Prolonged bleeding time (HP:0003010)2.88883356
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87032415
51Menorrhagia (HP:0000132)2.85900151
52Abnormality of skeletal muscle fiber size (HP:0012084)2.82408082
53Vacuolated lymphocytes (HP:0001922)2.82059222
54Hypoalphalipoproteinemia (HP:0003233)2.81820501
55Protrusio acetabuli (HP:0003179)2.81585479
56Peritonitis (HP:0002586)2.79068731
57Myositis (HP:0100614)2.76057977
58Abnormality of the intrinsic pathway (HP:0010989)2.72342329
59Purpura (HP:0000979)2.71594908
60Aneurysm (HP:0002617)2.71306568
61Periodontitis (HP:0000704)2.70990086
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.68103035
63Mitral valve prolapse (HP:0001634)2.63742352
64Fat malabsorption (HP:0002630)2.63113006
65Abnormal platelet volume (HP:0011876)2.62696071
66Atrophic scars (HP:0001075)2.62606304
67Joint laxity (HP:0001388)2.61567433
68Fragile skin (HP:0001030)2.61403731
69Broad ribs (HP:0000885)2.60164373
70Axonal loss (HP:0003447)2.59075194
71Biconcave vertebral bodies (HP:0004586)2.58255849
72Elbow flexion contracture (HP:0002987)2.58048465
73Increased cerebral lipofuscin (HP:0011813)2.55624544
74Recurrent skin infections (HP:0001581)2.55381917
75Elevated erythrocyte sedimentation rate (HP:0003565)2.54378117
76Abnormality of the lumbar spine (HP:0100712)2.52640190
77Nephritis (HP:0000123)2.52539570
78Abnormality of liposaccharide metabolism (HP:0010968)2.51945835
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.51945835
80Abnormality of glycolipid metabolism (HP:0010969)2.51945835
81Skin nodule (HP:0200036)2.51281285
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.51210598
83Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.50659477
84Spontaneous abortion (HP:0005268)2.45076445
85Thrombocytosis (HP:0001894)2.44689088
86Autoimmune thrombocytopenia (HP:0001973)2.43853240
87Thrombophlebitis (HP:0004418)2.43490335
88Abnormality of methionine metabolism (HP:0010901)2.43157839
89Increased mean platelet volume (HP:0011877)2.42964621
90Hypoventilation (HP:0002791)2.42054474
91Abnormal platelet function (HP:0011869)2.39922422
92Impaired platelet aggregation (HP:0003540)2.39922422
93Pulmonary embolism (HP:0002204)2.39875229
94Mitral stenosis (HP:0001718)2.33795773
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32899359
96Hyperammonemia (HP:0001987)2.32255223
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.30021371
98Abnormality of macrophages (HP:0004311)2.24359353
99Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23364853
100Petechiae (HP:0000967)2.22746354
101Conjunctival telangiectasia (HP:0000524)2.22187898
102Delayed cranial suture closure (HP:0000270)2.20478596
103Thoracic kyphosis (HP:0002942)2.19787619
104Urticaria (HP:0001025)2.19411117
105Joint stiffness (HP:0001387)2.18246188
106Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.18103255
107Mildly elevated creatine phosphokinase (HP:0008180)2.17961281
108Abnormality of polysaccharide metabolism (HP:0011012)2.17720604
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17720604
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17720604
111Spinal cord lesions (HP:0100561)2.16192581
112Syringomyelia (HP:0003396)2.16192581
113Shallow orbits (HP:0000586)2.16017054
114Hyperextensible skin (HP:0000974)2.15971576
115Arterial thrombosis (HP:0004420)2.15451181
116Ovoid vertebral bodies (HP:0003300)2.14615091
117Aortic regurgitation (HP:0001659)2.13976724
118Abnormality of the prostate (HP:0008775)2.11847347
119Hematochezia (HP:0002573)2.11481178
120Abnormality of pyrimidine metabolism (HP:0004353)2.10820347
121Vertebral compression fractures (HP:0002953)2.10205403
122Microcytic anemia (HP:0001935)2.08369714
123Conjugated hyperbilirubinemia (HP:0002908)2.07178432
124Steatorrhea (HP:0002570)2.06690269
125Orchitis (HP:0100796)2.05112666
126Long toe (HP:0010511)2.04340117
127Amyloidosis (HP:0011034)2.03780494
128Cellulitis (HP:0100658)2.03735939
129Bruising susceptibility (HP:0000978)2.03673131
130Abnormality of iron homeostasis (HP:0011031)2.03074955
131Generalized amyotrophy (HP:0003700)2.02142076
132Cervical subluxation (HP:0003308)2.01788704
133Neonatal short-limb short stature (HP:0008921)2.00769109
134Premature rupture of membranes (HP:0001788)2.00762904
135Hyperbilirubinemia (HP:0002904)2.00552479
136Thoracolumbar scoliosis (HP:0002944)1.99764107
137Urinary glycosaminoglycan excretion (HP:0003541)1.99672905
138Mucopolysacchariduria (HP:0008155)1.99672905
139Esophageal varix (HP:0002040)1.99520108
140Ketosis (HP:0001946)1.99270726
141Abnormality of the acetabulum (HP:0003170)1.99026870
142Dysostosis multiplex (HP:0000943)1.98924286
143Gingivitis (HP:0000230)1.98499210
144Abnormality of skull ossification (HP:0002703)1.97921252
145Hypoglycemic coma (HP:0001325)1.97109172
146Achilles tendon contracture (HP:0001771)1.95253307
147Mediastinal lymphadenopathy (HP:0100721)1.94356721
148Nausea (HP:0002018)1.93213242
149Aplastic anemia (HP:0001915)1.92037392
150Cupped ribs (HP:0000887)1.91781111
151Abnormality of the frontal sinuses (HP:0002687)1.91510427
152Hepatocellular carcinoma (HP:0001402)1.89644233
153Venous abnormality (HP:0002624)1.88251284
154Disproportionate tall stature (HP:0001519)1.87265001
155Craniofacial hyperostosis (HP:0004493)1.87243900
156Interstitial pulmonary disease (HP:0006530)1.86753861
157Redundant skin (HP:0001582)1.86483591
158Wide anterior fontanel (HP:0000260)1.86166010
159Spastic diplegia (HP:0001264)1.86111130
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.85627570
161Osteolytic defects of the hand bones (HP:0009699)1.85627570
162Abnormality of the peritoneum (HP:0002585)1.81805803
163Wrist flexion contracture (HP:0001239)1.80238756
164Abnormal delivery (HP:0001787)1.79621476
165Abnormality of the Achilles tendon (HP:0005109)1.75938511
166Persistence of primary teeth (HP:0006335)1.72448709
167Flared iliac wings (HP:0002869)1.71925999
168Polycythemia (HP:0001901)1.70791858
169Asymmetric septal hypertrophy (HP:0001670)1.70289491
170Short clavicles (HP:0000894)1.67918622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.35973531
2MYLK2.85464434
3BLK2.68443369
4ERN12.55411412
5TEC2.45592156
6IRAK42.33577349
7TAOK32.31832834
8TYK22.30590066
9NEK92.28499630
10SIK12.23040010
11CSF1R2.19804650
12BTK2.18406830
13PRPF4B2.14284417
14TGFBR22.13889520
15TBK12.11529291
16FRK2.00596481
17PAK21.96780301
18MAP4K11.90706431
19JAK31.90534150
20IRAK31.87526444
21TRIB31.79419787
22FLT31.77875995
23CAMK1D1.75900898
24BCKDK1.68906181
25MAP2K31.64015320
26RIPK41.61803692
27IKBKE1.58261705
28PKN21.57556585
29JAK11.53439805
30PRKD21.49973383
31GRK51.45052110
32FGFR41.44326670
33TXK1.43595577
34MATK1.38558895
35RIPK11.36667424
36AKT31.36597347
37MAP3K141.36583471
38FGFR31.35420080
39IKBKB1.33993983
40PIK3CG1.32613641
41NTRK11.29895511
42MAP3K131.28505842
43LYN1.28336356
44TGFBR11.27282674
45TRPM71.20995447
46MUSK1.20941420
47ZAP701.17144340
48MOS1.15659966
49EPHA31.13377310
50CDC42BPA1.12918615
51DDR21.11430649
52CAMKK21.10518091
53SYK1.08797482
54ADRBK21.07864377
55CSK1.07432025
56ADRBK11.07195602
57HCK1.06106656
58TIE11.05587224
59FES1.04265253
60LRRK21.00689283
61GSK3A1.00600079
62ABL20.98712092
63JAK20.95420598
64BMPR20.94317327
65PTK20.94253836
66CDK60.93345519
67EEF2K0.91858315
68KDR0.89434383
69EIF2AK20.87852963
70LCK0.87326444
71NME20.84358758
72MAPK70.84321664
73PTK60.83255332
74MAPK110.81337985
75MAP3K60.80676010
76EPHB20.80473938
77MTOR0.79755470
78CAMK1G0.79204129
79ERBB40.77936508
80PRKG20.77426854
81MAPKAPK50.76851746
82RPS6KA20.76346924
83TTN0.75750178
84ITK0.74766912
85RPS6KA40.73605405
86PDPK10.72077822
87MST1R0.71911264
88TAOK20.71482381
89INSRR0.71394475
90GRK10.69967110
91MAPK40.69215271
92CHUK0.68878875
93SCYL20.68551137
94EPHB10.66301294
95PRKAA20.66057671
96PIM20.65179823
97ICK0.64947536
98RPS6KC10.64544969
99RPS6KL10.64544969
100IRAK10.64532656
101HIPK20.64062166
102MKNK10.63799750
103MAP3K30.60119752
104IRAK20.59940206
105STK380.59613471
106IGF1R0.59607845
107PDGFRA0.59337642
108MAP3K10.59234272
109YES10.56941086
110MARK20.56274578
111MAPKAPK20.55713456
112EGFR0.54388729
113NUAK10.53730753
114CDK120.53180935
115TNIK0.52974899
116PIM10.52868751
117MAP3K70.52474899
118CDK40.51368522
119ABL10.50892653
120RPS6KA60.49721950
121CAMKK10.49468691
122MAP3K50.49170745
123CDK80.48868146
124CAMK40.46874088
125EIF2AK30.46758972
126GRK70.46142370
127LATS20.45563234
128MAPK120.45344806
129PRKCD0.45330990
130STK100.44473742
131PAK40.44224802
132GRK60.44095065
133PRKD10.42726660
134PIK3CA0.38059444
135TNK20.37520864
136FGR0.36268566
137CLK10.35473272
138STK30.33845709
139PDGFRB0.33035566
140EIF2AK10.32676775
141DMPK0.31971329

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13158809
2Staphylococcus aureus infection_Homo sapiens_hsa051503.75084966
3Complement and coagulation cascades_Homo sapiens_hsa046103.62199187
4Nitrogen metabolism_Homo sapiens_hsa009103.21038969
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82886788
6ECM-receptor interaction_Homo sapiens_hsa045122.48099866
7Caffeine metabolism_Homo sapiens_hsa002322.45500108
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36604983
9Arginine biosynthesis_Homo sapiens_hsa002202.05908660
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05057460
11Tryptophan metabolism_Homo sapiens_hsa003801.99087725
12Fatty acid degradation_Homo sapiens_hsa000711.97265145
13* Focal adhesion_Homo sapiens_hsa045101.90769603
14Peroxisome_Homo sapiens_hsa041461.83066688
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67776362
16Histidine metabolism_Homo sapiens_hsa003401.67734440
17PPAR signaling pathway_Homo sapiens_hsa033201.65942315
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.61456147
19Chronic myeloid leukemia_Homo sapiens_hsa052201.60607304
20Leishmaniasis_Homo sapiens_hsa051401.57583640
21Folate biosynthesis_Homo sapiens_hsa007901.55419651
22Acute myeloid leukemia_Homo sapiens_hsa052211.50669787
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47983221
24Chemical carcinogenesis_Homo sapiens_hsa052041.47786587
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43812938
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43588252
27* Malaria_Homo sapiens_hsa051441.41750316
28Renin-angiotensin system_Homo sapiens_hsa046141.41374724
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39206174
30Bladder cancer_Homo sapiens_hsa052191.37524652
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.37143417
32Starch and sucrose metabolism_Homo sapiens_hsa005001.36425602
33ABC transporters_Homo sapiens_hsa020101.35851812
34Fatty acid metabolism_Homo sapiens_hsa012121.34224959
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32985921
36Protein digestion and absorption_Homo sapiens_hsa049741.32248213
37Retinol metabolism_Homo sapiens_hsa008301.31334638
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30097638
39beta-Alanine metabolism_Homo sapiens_hsa004101.29968040
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27137612
41Pertussis_Homo sapiens_hsa051331.26095650
42Selenocompound metabolism_Homo sapiens_hsa004501.25737983
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21096311
44Small cell lung cancer_Homo sapiens_hsa052221.20153148
45Pancreatic cancer_Homo sapiens_hsa052121.16316440
46Legionellosis_Homo sapiens_hsa051341.15506586
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.13507504
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12984096
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09881698
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09302067
51* Proteoglycans in cancer_Homo sapiens_hsa052051.07355810
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05971165
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05560620
54Propanoate metabolism_Homo sapiens_hsa006401.03721262
55Steroid biosynthesis_Homo sapiens_hsa001001.03690854
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.03439000
57Osteoclast differentiation_Homo sapiens_hsa043801.02756103
58* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01798525
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01392697
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97655947
61Shigellosis_Homo sapiens_hsa051310.95797299
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.95748213
63* Melanoma_Homo sapiens_hsa052180.95703633
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94643752
65Tuberculosis_Homo sapiens_hsa051520.94054476
66Vitamin digestion and absorption_Homo sapiens_hsa049770.93031534
67Non-small cell lung cancer_Homo sapiens_hsa052230.91876481
68Lysosome_Homo sapiens_hsa041420.88396462
69N-Glycan biosynthesis_Homo sapiens_hsa005100.86537538
70Prostate cancer_Homo sapiens_hsa052150.86325933
71Prolactin signaling pathway_Homo sapiens_hsa049170.86210111
72MicroRNAs in cancer_Homo sapiens_hsa052060.85322512
73Butanoate metabolism_Homo sapiens_hsa006500.85106797
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84284036
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.84140515
76Pentose phosphate pathway_Homo sapiens_hsa000300.84012619
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.83745952
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83071531
79Measles_Homo sapiens_hsa051620.82425955
80Bile secretion_Homo sapiens_hsa049760.82118321
81Viral myocarditis_Homo sapiens_hsa054160.79764804
82Sulfur relay system_Homo sapiens_hsa041220.78792753
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77781074
84GnRH signaling pathway_Homo sapiens_hsa049120.76594581
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76528011
86Dilated cardiomyopathy_Homo sapiens_hsa054140.76331542
87Glioma_Homo sapiens_hsa052140.76296323
88One carbon pool by folate_Homo sapiens_hsa006700.76245890
89VEGF signaling pathway_Homo sapiens_hsa043700.75985528
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75438790
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75365567
92Fatty acid elongation_Homo sapiens_hsa000620.73404880
93Phenylalanine metabolism_Homo sapiens_hsa003600.72698193
94Hematopoietic cell lineage_Homo sapiens_hsa046400.72563144
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71906584
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70981413
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70608371
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70372820
99Phagosome_Homo sapiens_hsa041450.70021714
100TNF signaling pathway_Homo sapiens_hsa046680.69727591
101Fatty acid biosynthesis_Homo sapiens_hsa000610.67000703
102Apoptosis_Homo sapiens_hsa042100.66193740
103Other glycan degradation_Homo sapiens_hsa005110.65943113
104* Pathways in cancer_Homo sapiens_hsa052000.65845462
105* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65138995
106Rheumatoid arthritis_Homo sapiens_hsa053230.64614946
107Graft-versus-host disease_Homo sapiens_hsa053320.64128667
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63725804
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.62972780
110Platelet activation_Homo sapiens_hsa046110.62823650
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.62582418
112Choline metabolism in cancer_Homo sapiens_hsa052310.61059007
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.60932084
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60128155
115Estrogen signaling pathway_Homo sapiens_hsa049150.60126285
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59977733
117Lysine degradation_Homo sapiens_hsa003100.59630275
118Influenza A_Homo sapiens_hsa051640.58953855
119HTLV-I infection_Homo sapiens_hsa051660.58813884
120Tyrosine metabolism_Homo sapiens_hsa003500.58467679
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58446455
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58308776
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.56673970
124Notch signaling pathway_Homo sapiens_hsa043300.56171852
125Asthma_Homo sapiens_hsa053100.54589802
126African trypanosomiasis_Homo sapiens_hsa051430.53253587
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53222806
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.52699214
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52308049
130Chemokine signaling pathway_Homo sapiens_hsa040620.51669045
131Herpes simplex infection_Homo sapiens_hsa051680.51472076
132Biosynthesis of amino acids_Homo sapiens_hsa012300.50935182
133Sulfur metabolism_Homo sapiens_hsa009200.50471123
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50248231
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.50044674
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49928602
137Dorso-ventral axis formation_Homo sapiens_hsa043200.48620890
138* Renal cell carcinoma_Homo sapiens_hsa052110.47782811
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47755499
140B cell receptor signaling pathway_Homo sapiens_hsa046620.47333845
141Prion diseases_Homo sapiens_hsa050200.46643100
142Salmonella infection_Homo sapiens_hsa051320.46583142
143Allograft rejection_Homo sapiens_hsa053300.46272607
144Amoebiasis_Homo sapiens_hsa051460.45602369
145mTOR signaling pathway_Homo sapiens_hsa041500.45436767
146MAPK signaling pathway_Homo sapiens_hsa040100.45093632
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.45082438
148Vitamin B6 metabolism_Homo sapiens_hsa007500.44660607
149Antigen processing and presentation_Homo sapiens_hsa046120.44039510
150Galactose metabolism_Homo sapiens_hsa000520.42739192
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42556138
152Toxoplasmosis_Homo sapiens_hsa051450.42553776
153Carbon metabolism_Homo sapiens_hsa012000.42152953
154Hepatitis C_Homo sapiens_hsa051600.41572647
155Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40297213
156Fat digestion and absorption_Homo sapiens_hsa049750.39264088
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37219215
158Hepatitis B_Homo sapiens_hsa051610.35665144

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