HGH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.86036585
2DNA deamination (GO:0045006)7.79258621
3transcription from mitochondrial promoter (GO:0006390)7.29716171
4proline metabolic process (GO:0006560)6.56505974
5replication fork processing (GO:0031297)6.44989686
6embryonic process involved in female pregnancy (GO:0060136)6.05876795
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.65242948
8mitochondrial DNA metabolic process (GO:0032042)5.18383267
9positive regulation of protein homooligomerization (GO:0032464)5.17998564
10formation of translation preinitiation complex (GO:0001731)5.12288938
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.95773164
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.95773164
13viral mRNA export from host cell nucleus (GO:0046784)4.94652275
14telomere maintenance via semi-conservative replication (GO:0032201)4.87403660
15establishment of apical/basal cell polarity (GO:0035089)4.82369619
16oxidative demethylation (GO:0070989)4.80123684
17DNA unwinding involved in DNA replication (GO:0006268)4.74552787
18DNA strand renaturation (GO:0000733)4.66930731
19mitotic G1 DNA damage checkpoint (GO:0031571)4.55580214
20regulation of integrin activation (GO:0033623)4.51529319
21regulation of translational fidelity (GO:0006450)4.45919409
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.43934438
23regulation of protein homooligomerization (GO:0032462)4.38531767
24ribosomal small subunit biogenesis (GO:0042274)4.37899392
25mitotic chromosome condensation (GO:0007076)4.32503570
26DNA strand elongation involved in DNA replication (GO:0006271)4.32430974
27base-excision repair (GO:0006284)4.28761612
28nucleotide-excision repair, DNA gap filling (GO:0006297)4.25379386
29poly(A)+ mRNA export from nucleus (GO:0016973)4.23937418
30regulation of translational termination (GO:0006449)4.20040834
31mRNA cleavage (GO:0006379)4.19465808
32peptidyl-arginine omega-N-methylation (GO:0035247)4.12357867
33establishment or maintenance of monopolar cell polarity (GO:0061339)4.11452312
34establishment of monopolar cell polarity (GO:0061162)4.11452312
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.09635091
36DNA strand elongation (GO:0022616)4.07168512
37mitochondrial RNA metabolic process (GO:0000959)4.04874328
38telomere maintenance via recombination (GO:0000722)3.99259492
39mitotic G1/S transition checkpoint (GO:0044819)3.99168696
40G1 DNA damage checkpoint (GO:0044783)3.96347804
41negative regulation of cell cycle arrest (GO:0071157)3.93331859
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.87959280
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.85427381
44negative regulation of mRNA processing (GO:0050686)3.85066413
45termination of RNA polymerase II transcription (GO:0006369)3.83997666
46negative regulation of JAK-STAT cascade (GO:0046426)3.79585361
47regulation of double-strand break repair via homologous recombination (GO:0010569)3.78662079
48COPI coating of Golgi vesicle (GO:0048205)3.70750488
49Golgi transport vesicle coating (GO:0048200)3.70750488
50negative regulation of RNA splicing (GO:0033119)3.68860717
51non-recombinational repair (GO:0000726)3.61536474
52double-strand break repair via nonhomologous end joining (GO:0006303)3.61536474
53maturation of 5.8S rRNA (GO:0000460)3.59857146
54DNA double-strand break processing (GO:0000729)3.58773674
55base-excision repair, AP site formation (GO:0006285)3.53456662
56peptidyl-arginine methylation (GO:0018216)3.53122164
57peptidyl-arginine N-methylation (GO:0035246)3.53122164
58telomere maintenance via telomere lengthening (GO:0010833)3.52331069
59DNA integration (GO:0015074)3.51217476
60meiotic chromosome segregation (GO:0045132)3.48173931
61pseudouridine synthesis (GO:0001522)3.47882691
62dosage compensation (GO:0007549)3.47400476
63embryonic placenta development (GO:0001892)3.47267596
64mitotic recombination (GO:0006312)3.45074143
65nuclear pore complex assembly (GO:0051292)3.44447997
66positive regulation of developmental pigmentation (GO:0048087)3.44319688
67kinetochore assembly (GO:0051382)3.44027036
68protein maturation by protein folding (GO:0022417)3.42741682
69regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41044741
70DNA topological change (GO:0006265)3.39314181
71mitochondrial DNA replication (GO:0006264)3.39164320
72ribosome biogenesis (GO:0042254)3.38844106
73histone arginine methylation (GO:0034969)3.32857831
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.32503578
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32503578
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32503578
77histone H4-K12 acetylation (GO:0043983)3.31837106
78pentose-phosphate shunt (GO:0006098)3.30347699
79glutamine family amino acid biosynthetic process (GO:0009084)3.28271749
80regulation of sister chromatid cohesion (GO:0007063)3.27201456
81positive regulation by host of viral transcription (GO:0043923)3.26489411
82GDP-mannose metabolic process (GO:0019673)3.26047381
83positive regulation of protein oligomerization (GO:0032461)3.24620558
84cellular response to zinc ion (GO:0071294)3.24506320
85DNA ligation (GO:0006266)3.23556287
86ribonucleoprotein complex biogenesis (GO:0022613)3.19822752
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18391145
88pyrimidine nucleotide catabolic process (GO:0006244)3.18219164
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18071449
90negative regulation of mRNA metabolic process (GO:1903312)3.17319701
91regulation of double-strand break repair (GO:2000779)3.17144401
92trophectodermal cell differentiation (GO:0001829)3.15391561
93regulation of DNA damage checkpoint (GO:2000001)3.14414133
94nodal signaling pathway (GO:0038092)3.12824464
95regulation of RNA export from nucleus (GO:0046831)3.10617284
96maturation of SSU-rRNA (GO:0030490)3.08838384
97positive regulation of DNA repair (GO:0045739)3.08270734
98UV protection (GO:0009650)3.05414906
99rRNA transcription (GO:0009303)3.05395397
100protein complex localization (GO:0031503)3.05123936
101cellular response to ATP (GO:0071318)3.00469996
102kinetochore organization (GO:0051383)3.00101233
103positive regulation of chromosome segregation (GO:0051984)2.99612752
104regulation of gene silencing by RNA (GO:0060966)2.99381924
105regulation of posttranscriptional gene silencing (GO:0060147)2.99381924
106regulation of gene silencing by miRNA (GO:0060964)2.99381924
107mRNA export from nucleus (GO:0006406)2.98679043
108cullin deneddylation (GO:0010388)2.95550142
109rRNA processing (GO:0006364)2.94988721
110folic acid metabolic process (GO:0046655)2.93275365
111mitotic sister chromatid segregation (GO:0000070)2.92529981
112activation of Rac GTPase activity (GO:0032863)2.92436116
113regulation of early endosome to late endosome transport (GO:2000641)2.91669272
114negative regulation of gene silencing (GO:0060969)2.91248424
115spliceosomal snRNP assembly (GO:0000387)2.90448623
116nuclear envelope reassembly (GO:0031468)2.90249323
117mitotic nuclear envelope reassembly (GO:0007084)2.90249323
118single strand break repair (GO:0000012)2.89658582
119negative regulation of fatty acid biosynthetic process (GO:0045717)2.89561710
120NADPH regeneration (GO:0006740)2.88977418
121apoptotic process involved in morphogenesis (GO:0060561)2.88276929
122regulation of protein oligomerization (GO:0032459)2.86478477
123RNA export from nucleus (GO:0006405)2.85441968
124protein export from nucleus (GO:0006611)2.85291965
125DNA replication initiation (GO:0006270)2.84948783
126translational initiation (GO:0006413)2.84932763
127snRNA metabolic process (GO:0016073)2.82182515
128glucose catabolic process (GO:0006007)2.80672097
129mitochondrial fusion (GO:0008053)2.79933195
1303-UTR-mediated mRNA stabilization (GO:0070935)2.79922868
131negative regulation of cell size (GO:0045792)2.79811466
132chromosome condensation (GO:0030261)2.78821923
133regulation of cell cycle checkpoint (GO:1901976)2.76230708
134cellular protein complex localization (GO:0034629)2.74323268
135protein localization to chromosome, centromeric region (GO:0071459)2.74282882
136negative regulation of viral release from host cell (GO:1902187)2.73120770
137nuclear pore organization (GO:0006999)2.70596706
138viral transcription (GO:0019083)2.67252353
139regulation of nucleobase-containing compound transport (GO:0032239)2.64610133
140maternal placenta development (GO:0001893)2.63383873
141nucleobase-containing small molecule interconversion (GO:0015949)2.60585969
142ncRNA 3-end processing (GO:0043628)2.60044053
143pentose metabolic process (GO:0019321)2.59728831
144pinocytosis (GO:0006907)2.59391317
145negative regulation of erythrocyte differentiation (GO:0045647)2.59357707
146intracellular estrogen receptor signaling pathway (GO:0030520)2.59291229
147regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.58174180
148mitotic nuclear envelope disassembly (GO:0007077)2.57048302
149mitotic metaphase plate congression (GO:0007080)2.55119467
150chaperone mediated protein folding requiring cofactor (GO:0051085)2.55111270
151heterochromatin organization (GO:0070828)2.53496298
152DNA duplex unwinding (GO:0032508)2.51840881
153positive regulation of DNA-templated transcription, elongation (GO:0032786)2.50257642
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49428113
155translational termination (GO:0006415)2.48332449
156inner cell mass cell proliferation (GO:0001833)2.47255451
157negative regulation of DNA-templated transcription, elongation (GO:0032785)2.46034588
158translational elongation (GO:0006414)2.44472761
159pore complex assembly (GO:0046931)2.41986721
160RNA stabilization (GO:0043489)2.40406867
161mRNA stabilization (GO:0048255)2.40406867
162snRNA processing (GO:0016180)2.40127413
163positive regulation of keratinocyte differentiation (GO:0045618)2.38949506
164regulation of translational elongation (GO:0006448)2.36194030
165DNA conformation change (GO:0071103)2.35021796
166nuclear envelope disassembly (GO:0051081)2.34985468
167membrane disassembly (GO:0030397)2.34985468
168peptidyl-arginine modification (GO:0018195)2.34514885
169DNA replication checkpoint (GO:0000076)2.33827526
170tRNA methylation (GO:0030488)2.33358208
171DNA geometric change (GO:0032392)2.31199392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.53268549
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89569496
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35341541
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84988403
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76784289
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68338620
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61950541
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47168373
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.40662941
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39771434
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34238401
12VDR_21846776_ChIP-Seq_THP-1_Human2.30002167
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17508459
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.12596015
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.11656981
16MYC_22102868_ChIP-Seq_BL_Human2.05870608
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02710246
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02710246
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02710246
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.98603130
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98318552
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85517476
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83218221
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82836184
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81000412
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80024827
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76177168
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75257412
29GABP_19822575_ChIP-Seq_HepG2_Human1.75102052
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74561258
31XRN2_22483619_ChIP-Seq_HELA_Human1.73828807
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.72432572
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72237559
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71486853
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68184769
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68098371
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.67894752
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.67230265
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66962070
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65621083
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65437203
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64800055
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.62502216
44DCP1A_22483619_ChIP-Seq_HELA_Human1.61929608
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60605890
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56872979
47PU.1_20513432_ChIP-Seq_Bcells_Mouse1.54429796
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53341674
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52916262
50TCF7_22412390_ChIP-Seq_EML_Mouse1.51461456
51TTF2_22483619_ChIP-Seq_HELA_Human1.50585583
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49156585
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47420221
54POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45598846
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.45595379
56VDR_23849224_ChIP-Seq_CD4+_Human1.43971375
57LXR_22292898_ChIP-Seq_THP-1_Human1.43456443
58KDM5A_27292631_Chip-Seq_BREAST_Human1.43373392
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42285536
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42019585
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41716037
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40318655
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40113938
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39799209
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39500457
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39451718
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.38376616
68KDM2B_26808549_Chip-Seq_DND41_Human1.37573777
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36723482
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36069036
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35953616
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34518657
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.33363371
74P68_20966046_ChIP-Seq_HELA_Human1.33250033
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33196477
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33105057
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32391626
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31974831
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.31111253
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31077145
81MAF_26560356_Chip-Seq_TH1_Human1.30401615
82CIITA_25753668_ChIP-Seq_RAJI_Human1.27962432
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27428315
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27311076
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26299479
86VDR_24763502_ChIP-Seq_THP-1_Human1.23400147
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.22511231
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21742346
89NCOR1_26117541_ChIP-Seq_K562_Human1.20000862
90ZNF263_19887448_ChIP-Seq_K562_Human1.18600626
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18464598
92AR_21909140_ChIP-Seq_LNCAP_Human1.18185374
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18089516
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17289870
95ATF3_27146783_Chip-Seq_COLON_Human1.16838733
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16609459
97MAF_26560356_Chip-Seq_TH2_Human1.15862601
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15589626
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.15582088
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15480078
101FOXP3_21729870_ChIP-Seq_TREG_Human1.15226847
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15208978
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15051458
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13737636
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.11867630
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11784253
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10056858
108TFEB_21752829_ChIP-Seq_HELA_Human1.09711114
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09615773
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09180603
111SMC4_20622854_ChIP-Seq_HELA_Human1.08954207
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08946587
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08742817
114UTX_26944678_Chip-Seq_JUKART_Human1.08704893
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07541194
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.06602386
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05677763
118ETS1_21867929_ChIP-Seq_TH2_Mouse1.04771544
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04517900
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04074037
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03663700
122RACK7_27058665_Chip-Seq_MCF-7_Human1.03446863
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.03278592
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02545476
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02516784
126SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02267931
127CREB1_26743006_Chip-Seq_LNCaP_Human1.02056492
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.02037765
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01851413
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01514988
131OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01509913
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.00881558
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00353097
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99936946
135SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99922185
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99319079
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.99209068
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98987546
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98777105
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98378924
141CTCF_26484167_Chip-Seq_Bcells_Mouse0.98303420
142RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96894011
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96297220
144FOXP1_21924763_ChIP-Seq_HESCs_Human0.95929360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.11228852
2MP0009278_abnormal_bone_marrow3.73200450
3MP0005451_abnormal_body_composition3.71688260
4MP0010030_abnormal_orbit_morphology3.60061515
5MP0003705_abnormal_hypodermis_morpholog3.55388070
6MP0010094_abnormal_chromosome_stability3.46052406
7MP0004957_abnormal_blastocyst_morpholog3.08478113
8MP0005171_absent_coat_pigmentation2.99288840
9MP0004185_abnormal_adipocyte_glucose2.96091427
10MP0003693_abnormal_embryo_hatching2.84273317
11MP0003111_abnormal_nucleus_morphology2.83335234
12MP0008260_abnormal_autophagy2.71534303
13MP0004233_abnormal_muscle_weight2.62486484
14MP0008058_abnormal_DNA_repair2.53135222
15MP0005174_abnormal_tail_pigmentation2.49540897
16MP0002009_preneoplasia2.48895739
17MP0001545_abnormal_hematopoietic_system2.42404829
18MP0005397_hematopoietic_system_phenotyp2.42404829
19MP0001849_ear_inflammation2.38115532
20MP0003786_premature_aging2.33477341
21MP0008995_early_reproductive_senescence2.31063616
22MP0003077_abnormal_cell_cycle2.29476489
23MP0003890_abnormal_embryonic-extraembry2.21775002
24MP0008877_abnormal_DNA_methylation2.15504383
25MP0008932_abnormal_embryonic_tissue2.07403346
26MP0002877_abnormal_melanocyte_morpholog2.04071932
27MP0004133_heterotaxia2.00782928
28MP0000490_abnormal_crypts_of1.87367920
29MP0003119_abnormal_digestive_system1.85102940
30MP0005075_abnormal_melanosome_morpholog1.80975528
31MP0010352_gastrointestinal_tract_polyps1.79525242
32MP0001697_abnormal_embryo_size1.77391970
33MP0010234_abnormal_vibrissa_follicle1.77387270
34MP0000015_abnormal_ear_pigmentation1.76809773
35MP0003283_abnormal_digestive_organ1.75377492
36MP0002653_abnormal_ependyma_morphology1.68699939
37MP0002086_abnormal_extraembryonic_tissu1.67533370
38MP0002084_abnormal_developmental_patter1.67452385
39MP0000678_abnormal_parathyroid_gland1.67195014
40MP0006072_abnormal_retinal_apoptosis1.63447261
41MP0000350_abnormal_cell_proliferation1.59158982
42MP0002085_abnormal_embryonic_tissue1.56519215
43MP0001730_embryonic_growth_arrest1.56159516
44MP0001293_anophthalmia1.55902497
45MP0000537_abnormal_urethra_morphology1.54214651
46MP0003566_abnormal_cell_adhesion1.53747515
47MP0002396_abnormal_hematopoietic_system1.51161270
48MP0005380_embryogenesis_phenotype1.50480146
49MP0001672_abnormal_embryogenesis/_devel1.50480146
50MP0002249_abnormal_larynx_morphology1.49091106
51MP0003567_abnormal_fetal_cardiomyocyte1.44094524
52MP0004197_abnormal_fetal_growth/weight/1.43373455
53MP0005076_abnormal_cell_differentiation1.39996884
54MP0003172_abnormal_lysosome_physiology1.37071640
55MP0009840_abnormal_foam_cell1.36534937
56MP0003436_decreased_susceptibility_to1.36098075
57MP0003453_abnormal_keratinocyte_physiol1.35446268
58MP0002019_abnormal_tumor_incidence1.34951419
59MP0004808_abnormal_hematopoietic_stem1.33653646
60MP0002080_prenatal_lethality1.30312021
61MP0005666_abnormal_adipose_tissue1.29991247
62MP0004858_abnormal_nervous_system1.28900269
63MP0000371_diluted_coat_color1.28194901
64MP0000003_abnormal_adipose_tissue1.27312775
65MP0008007_abnormal_cellular_replicative1.26936511
66MP0004947_skin_inflammation1.25701439
67MP0000858_altered_metastatic_potential1.25487221
68MP0000750_abnormal_muscle_regeneration1.25325813
69MP0003984_embryonic_growth_retardation1.23445379
70MP0009672_abnormal_birth_weight1.22081547
71MP0008438_abnormal_cutaneous_collagen1.21744307
72MP0001661_extended_life_span1.20404663
73MP0002282_abnormal_trachea_morphology1.20304763
74MP0010307_abnormal_tumor_latency1.19845856
75MP0002088_abnormal_embryonic_growth/wei1.18617440
76MP0000313_abnormal_cell_death1.17444753
77MP0001216_abnormal_epidermal_layer1.15974482
78MP0009333_abnormal_splenocyte_physiolog1.15536188
79MP0005375_adipose_tissue_phenotype1.14327514
80MP0001243_abnormal_dermal_layer1.14290252
81MP0003718_maternal_effect1.13503076
82MP0000685_abnormal_immune_system1.12302452
83MP0002111_abnormal_tail_morphology1.10223419
84MP0002089_abnormal_postnatal_growth/wei1.10081600
85MP0000470_abnormal_stomach_morphology1.09639963
86MP0005621_abnormal_cell_physiology1.07244912
87MP0001881_abnormal_mammary_gland1.06533404
88MP0001915_intracranial_hemorrhage1.05093679
89MP0009931_abnormal_skin_appearance1.05020746
90MP0001348_abnormal_lacrimal_gland1.04874877
91MP0002269_muscular_atrophy1.04599660
92MP0005623_abnormal_meninges_morphology1.02886447
93MP0003941_abnormal_skin_development1.00090987
94MP0002075_abnormal_coat/hair_pigmentati0.98623121
95MP0003763_abnormal_thymus_physiology0.97513761
96MP0003806_abnormal_nucleotide_metabolis0.97482474
97MP0005058_abnormal_lysosome_morphology0.95980485
98MP0006035_abnormal_mitochondrial_morpho0.92950473
99MP0002405_respiratory_system_inflammati0.91894747
100MP0003300_gastrointestinal_ulcer0.91836185
101MP0001145_abnormal_male_reproductive0.91251116
102MP0000689_abnormal_spleen_morphology0.91129867
103MP0000579_abnormal_nail_morphology0.88356733
104MP0000733_abnormal_muscle_development0.87728023
105MP0002254_reproductive_system_inflammat0.86863467
106MP0005384_cellular_phenotype0.85063510
107MP0003656_abnormal_erythrocyte_physiolo0.84718949
108MP0004264_abnormal_extraembryonic_tissu0.84393092
109MP0001727_abnormal_embryo_implantation0.84033598
110MP0000747_muscle_weakness0.83652778
111MP0001186_pigmentation_phenotype0.83108396
112MP0002932_abnormal_joint_morphology0.82566898
113MP0005023_abnormal_wound_healing0.82328219
114MP0005266_abnormal_metabolism0.82189952
115MP0000759_abnormal_skeletal_muscle0.81615078
116MP0003091_abnormal_cell_migration0.81238984
117MP0002970_abnormal_white_adipose0.79796324
118MP0000703_abnormal_thymus_morphology0.78902247
119MP0010630_abnormal_cardiac_muscle0.78541996
120MP0005257_abnormal_intraocular_pressure0.78509442
121MP0002429_abnormal_blood_cell0.78032529
122MP0000627_abnormal_mammary_gland0.77624638
123MP0002114_abnormal_axial_skeleton0.77502370
124MP0005083_abnormal_biliary_tract0.77308444
125MP0000377_abnormal_hair_follicle0.75588050
126MP0001853_heart_inflammation0.75137114
127MP0002210_abnormal_sex_determination0.74950020
128MP0001929_abnormal_gametogenesis0.74648966
129MP0002398_abnormal_bone_marrow0.74185102
130MP0001340_abnormal_eyelid_morphology0.74156152
131MP0002722_abnormal_immune_system0.74150717
132MP0000462_abnormal_digestive_system0.74015013
133MP0005464_abnormal_platelet_physiology0.73204267
134MP0005501_abnormal_skin_physiology0.71319322
135MP0002796_impaired_skin_barrier0.70898367
136MP0002166_altered_tumor_susceptibility0.70682145
137MP0003935_abnormal_craniofacial_develop0.68969423
138MP0000477_abnormal_intestine_morphology0.67603755
139MP0000653_abnormal_sex_gland0.67278062
140MP0001873_stomach_inflammation0.64923438
141MP0000049_abnormal_middle_ear0.64643402
142MP0000358_abnormal_cell_content/0.64291188
143MP0000639_abnormal_adrenal_gland0.63014738
144MP0000432_abnormal_head_morphology0.62700485
145MP0000762_abnormal_tongue_morphology0.62596421
146MP0002116_abnormal_craniofacial_bone0.60707669
147MP0002060_abnormal_skin_morphology0.60051262
148MP0009053_abnormal_anal_canal0.59510935
149MP0003755_abnormal_palate_morphology0.59337383
150MP0001324_abnormal_eye_pigmentation0.58097947
151MP0003943_abnormal_hepatobiliary_system0.58076732
152MP0003828_pulmonary_edema0.57216291

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.17188045
2Poikiloderma (HP:0001029)4.86073288
3Facial hemangioma (HP:0000329)4.82157797
4Concave nail (HP:0001598)4.69036644
5Pustule (HP:0200039)4.59615236
6Annular pancreas (HP:0001734)4.45154234
7Rectal fistula (HP:0100590)4.38248510
8Rectovaginal fistula (HP:0000143)4.38248510
9Hyperacusis (HP:0010780)4.33501274
10Tongue fasciculations (HP:0001308)4.10718634
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.07971835
12Increased IgM level (HP:0003496)4.04646073
13Intestinal fistula (HP:0100819)3.96895107
14Vaginal fistula (HP:0004320)3.83385661
15Muscle fibrillation (HP:0010546)3.69002073
16Squamous cell carcinoma (HP:0002860)3.64102780
17Alopecia of scalp (HP:0002293)3.59227182
18Intestinal atresia (HP:0011100)3.58506785
19Aplasia/hypoplasia of the humerus (HP:0006507)3.54837558
20Short humerus (HP:0005792)3.49493339
21Absent thumb (HP:0009777)3.48847467
22Ulnar bowing (HP:0003031)3.46886457
23Absent radius (HP:0003974)3.45423356
24Selective tooth agenesis (HP:0001592)3.43468383
25Achilles tendon contracture (HP:0001771)3.34814470
26Hypochromic microcytic anemia (HP:0004840)3.34009654
27Turricephaly (HP:0000262)3.32558878
28Basal cell carcinoma (HP:0002671)3.29720949
29Albinism (HP:0001022)3.25900162
30Abnormal hemoglobin (HP:0011902)3.25282450
31Aplasia involving forearm bones (HP:0009822)3.22175757
32Absent forearm bone (HP:0003953)3.22175757
33Orthostatic hypotension (HP:0001278)3.17787514
34Patellar aplasia (HP:0006443)3.14641445
35Ragged-red muscle fibers (HP:0003200)3.13739251
36Microvesicular hepatic steatosis (HP:0001414)3.11712919
37Male infertility (HP:0003251)3.10726067
38Premature graying of hair (HP:0002216)3.07199121
39Abnormality of male internal genitalia (HP:0000022)2.98234814
40Progressive muscle weakness (HP:0003323)2.95908055
41Broad alveolar ridges (HP:0000187)2.95159716
42Abnormality of the Achilles tendon (HP:0005109)2.93861667
43Aplasia/Hypoplasia of the patella (HP:0006498)2.88875723
44Short chin (HP:0000331)2.88791810
45Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85574927
46Vertebral hypoplasia (HP:0008417)2.85574927
47Deep palmar crease (HP:0006191)2.83506003
48Coronal craniosynostosis (HP:0004440)2.81418014
49Congenital hip dislocation (HP:0001374)2.80699051
50Volvulus (HP:0002580)2.79097498
51Trismus (HP:0000211)2.77867267
52Anteriorly placed anus (HP:0001545)2.75602968
53Abnormality of the aortic arch (HP:0012303)2.74999786
54Abnormal number of erythroid precursors (HP:0012131)2.72679712
55Hypochromic anemia (HP:0001931)2.72191331
56Abnormality of cells of the erythroid lineage (HP:0012130)2.66145635
57Dysautonomia (HP:0002459)2.66059072
58Increased connective tissue (HP:0009025)2.58938670
59Large for gestational age (HP:0001520)2.57853835
60Abnormality of the distal phalanges of the toes (HP:0010182)2.54657253
61Broad face (HP:0000283)2.53805388
62Muscle fiber atrophy (HP:0100295)2.53242377
63Acute lymphatic leukemia (HP:0006721)2.52314349
64Alacrima (HP:0000522)2.48736621
65Hypoplasia of the radius (HP:0002984)2.48719740
66Urinary glycosaminoglycan excretion (HP:0003541)2.47307209
67Mucopolysacchariduria (HP:0008155)2.47307209
68Insomnia (HP:0100785)2.46326662
69Bifid uvula (HP:0000193)2.46059446
70Asymmetry of the thorax (HP:0001555)2.45897736
71Premature skin wrinkling (HP:0100678)2.44898848
72IgA deficiency (HP:0002720)2.44591576
73Joint stiffness (HP:0001387)2.42594626
74Pancreatic islet-cell hyperplasia (HP:0004510)2.40889861
75Capillary hemangiomas (HP:0005306)2.40779145
76Sparse lateral eyebrow (HP:0005338)2.39481847
77Glossoptosis (HP:0000162)2.39028566
78Broad distal phalanx of finger (HP:0009836)2.38874485
79Vertebral compression fractures (HP:0002953)2.37805305
80Type 2 muscle fiber atrophy (HP:0003554)2.36888939
81Premature rupture of membranes (HP:0001788)2.36666389
82Long palpebral fissure (HP:0000637)2.35634292
83Spinal cord lesions (HP:0100561)2.35559244
84Syringomyelia (HP:0003396)2.35559244
85Ankle contracture (HP:0006466)2.35341817
86Hypotelorism (HP:0000601)2.32366851
87Popliteal pterygium (HP:0009756)2.30370904
88Cutaneous melanoma (HP:0012056)2.27002673
89Abnormal number of incisors (HP:0011064)2.26934564
90Overriding aorta (HP:0002623)2.23291109
91Diaphragmatic weakness (HP:0009113)2.23185748
92Dysostosis multiplex (HP:0000943)2.22358623
93Reticulocytosis (HP:0001923)2.20719542
94Abnormality of the ileum (HP:0001549)2.20572140
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18792979
96Abnormality of polysaccharide metabolism (HP:0011012)2.18792979
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18792979
98Myopathic facies (HP:0002058)2.16804481
99Breast hypoplasia (HP:0003187)2.16020399
100Spinal muscular atrophy (HP:0007269)2.15178584
101Centrally nucleated skeletal muscle fibers (HP:0003687)2.14004115
102Exertional dyspnea (HP:0002875)2.13796975
103Abnormality of the anterior horn cell (HP:0006802)2.13376091
104Degeneration of anterior horn cells (HP:0002398)2.13376091
105Polycythemia (HP:0001901)2.13048415
106Hypotrichosis (HP:0001006)2.11653959
107Vertebral fusion (HP:0002948)2.11086519
108Hamartoma (HP:0010566)2.09371268
109Hypokinesia (HP:0002375)2.08870061
110Elbow flexion contracture (HP:0002987)2.07772319
111Patellar dislocation (HP:0002999)2.06709175
112Progressive external ophthalmoplegia (HP:0000590)2.06687404
113Growth hormone excess (HP:0000845)2.05830029
114Elfin facies (HP:0004428)2.05824173
115Increased number of teeth (HP:0011069)2.05712084
116Neoplasm of the oral cavity (HP:0100649)2.04974902
117Rough bone trabeculation (HP:0100670)2.03552622
118Distal lower limb amyotrophy (HP:0008944)2.03515278
119Abnormality of reticulocytes (HP:0004312)2.03485827
120Abnormality of the labia minora (HP:0012880)2.03381715
121Gastrointestinal atresia (HP:0002589)2.03145317
122Choanal stenosis (HP:0000452)2.02664455
123Axonal loss (HP:0003447)2.02555724
124Abnormality of the umbilical cord (HP:0010881)2.01201692
125Distal upper limb amyotrophy (HP:0007149)2.00098209
126Upper limb amyotrophy (HP:0009129)2.00098209
127Astrocytoma (HP:0009592)1.99418021
128Abnormality of the astrocytes (HP:0100707)1.99418021
129Bulbar palsy (HP:0001283)1.98867259
130Abnormality of subcutaneous fat tissue (HP:0001001)1.98805195
131Redundant skin (HP:0001582)1.98522803
132Bowed forearm bones (HP:0003956)1.96791680
133Bowing of the arm (HP:0006488)1.96791680
134Generalized amyotrophy (HP:0003700)1.95560865
135Short thumb (HP:0009778)1.95157884
136Distal lower limb muscle weakness (HP:0009053)1.95036544
137Biconcave vertebral bodies (HP:0004586)1.94706955
138Cholecystitis (HP:0001082)1.94596631
139Abnormal gallbladder physiology (HP:0012438)1.94596631
140Cellulitis (HP:0100658)1.94351252
141Decreased lacrimation (HP:0000633)1.93789744
142Fragile skin (HP:0001030)1.93597327
143Multiple enchondromatosis (HP:0005701)1.93458744
144Short 5th finger (HP:0009237)1.92026100
145Cheilitis (HP:0100825)1.91993106
146Clumsiness (HP:0002312)1.91405238
147Easy fatigability (HP:0003388)1.91314078
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90080665
149Split hand (HP:0001171)1.87623067
150Hypertensive crisis (HP:0100735)1.87166882
151Protrusio acetabuli (HP:0003179)1.86173971
152Disproportionate tall stature (HP:0001519)1.83812866
153Stridor (HP:0010307)1.83747480
154Testicular atrophy (HP:0000029)1.83138274
155Self-mutilation (HP:0000742)1.82364908
156Renal duplication (HP:0000075)1.81228570
157Decreased subcutaneous fat (HP:0001002)1.80716984
158Hypertriglyceridemia (HP:0002155)1.77222378
159Increased variability in muscle fiber diameter (HP:0003557)1.76758335
160Abnormality of skeletal muscle fiber size (HP:0012084)1.76674138
161Abnormality of the thoracic spine (HP:0100711)1.75794322
162Short nail (HP:0001799)1.74919820
163Thin bony cortex (HP:0002753)1.74766296
164Deviation of the thumb (HP:0009603)1.74303407
165Hypoparathyroidism (HP:0000829)1.69447442
166Premature ovarian failure (HP:0008209)1.69163325
167Proximal placement of thumb (HP:0009623)1.68621932
168Nonimmune hydrops fetalis (HP:0001790)1.68192560
169Increased nuchal translucency (HP:0010880)1.68087683
170Renovascular hypertension (HP:0100817)1.67667892
171Reticulocytopenia (HP:0001896)1.67103540
172Recurrent viral infections (HP:0004429)1.65386229
173Back pain (HP:0003418)1.65355907
174Progressive hearing impairment (HP:0001730)1.63653909
175Aplasia/Hypoplasia of the thymus (HP:0010515)1.63044193
176Truncus arteriosus (HP:0001660)1.62009414
177Colitis (HP:0002583)1.61441050
178Spinal rigidity (HP:0003306)1.61230901
179Entropion (HP:0000621)1.60623990
180Abnormality of the tricuspid valve (HP:0001702)1.60092495
181B lymphocytopenia (HP:0010976)1.58815746
182Polygenic inheritance (HP:0010982)1.57678240
183Hyperthyroidism (HP:0000836)1.57168302
184Flared metaphyses (HP:0003015)1.55719823
185Seborrheic dermatitis (HP:0001051)1.55642459
186Reduced subcutaneous adipose tissue (HP:0003758)1.55603015
187Upper motor neuron abnormality (HP:0002127)1.55403444
188Spinal cord compression (HP:0002176)1.55040742
189Deep philtrum (HP:0002002)1.54878720
190Abnormal trabecular bone morphology (HP:0100671)1.54212966
191Mildly elevated creatine phosphokinase (HP:0008180)1.53566786
192Panhypogammaglobulinemia (HP:0003139)1.51874580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.52737583
2MAPK154.41537330
3MAP3K64.28548977
4DDR24.27494194
5SMG13.80266893
6MAP3K113.61453570
7PIM23.00285773
8IRAK32.98776061
9PINK12.82914837
10ERN12.79432508
11IRAK42.74552622
12MATK2.72144834
13DAPK12.44076258
14FGR2.40816309
15SIK12.34505997
16TYRO32.32430894
17CDK72.18056029
18UHMK12.00404843
19PRKD21.95576550
20BMX1.95237023
21TAF11.91460517
22YES11.89760052
23CSK1.81315401
24BUB11.79695663
25DYRK1B1.79050130
26MST1R1.67258140
27PIM11.67045034
28WEE11.62510160
29ILK1.60988991
30DYRK31.60415909
31BRAF1.59238371
32PKN21.51230453
33PDGFRA1.51082659
34TTN1.49716849
35MAP3K101.47571717
36VRK21.43197887
37CDK61.37673331
38CHEK21.36273885
39PTK21.31243636
40PLK11.30503441
41NEK21.23627391
42CDC71.22667788
43AKT31.19781802
44TRPM71.15888889
45RPS6KL11.14943560
46RPS6KC11.14943560
47MET1.13423418
48LATS21.11563785
49RPS6KB21.07960182
50TESK11.06786491
51LRRK21.06530215
52ATR1.05757918
53MAPK111.01266493
54PTK60.99818883
55RPS6KA60.99251259
56MAP2K20.98984247
57TAOK20.93841907
58GSK3A0.85894066
59FGFR40.85400650
60TSSK60.83961564
61RAF10.82915919
62NME20.81899041
63ARAF0.81522290
64RIPK10.79164929
65IRAK20.77778505
66MAP3K130.77428960
67EPHA20.76857907
68TTK0.76801266
69CDK120.74316911
70AURKA0.74316657
71CDC42BPA0.70729608
72MTOR0.69084063
73CDK40.68683235
74HIPK20.68497253
75RPS6KA10.68313397
76CDK20.66221655
77MAP4K10.65668492
78AURKB0.65239312
79EIF2AK10.63660912
80TESK20.62526564
81TLK10.62326475
82CDK90.61474578
83CSNK2A10.61152720
84CHEK10.61099300
85CLK10.61032928
86ABL20.60685113
87MUSK0.58933201
88EPHB10.58911235
89RPS6KA40.58792634
90PRKD30.58291678
91KSR20.55770101
92RPS6KA20.55485494
93PHKG20.55184794
94PHKG10.55184794
95PDPK10.54678801
96LMTK20.53600072
97MAPKAPK30.53282785
98CSNK2A20.51304176
99PIK3CG0.50672753
100PBK0.50527136
101TBK10.49319206
102RPS6KB10.48217796
103SRPK10.48047641
104ATM0.47534883
105ACVR1B0.47195792
106LYN0.46490873
107STK100.46454889
108BRSK10.45028833
109MAP3K10.44640371
110PRKAA10.43188027
111MARK30.42993985
112EEF2K0.42951352
113ALK0.42647020
114PRPF4B0.42487043
115TAOK10.42203040
116PAK40.42188895
117NEK10.41665349
118DYRK20.41402614
119STK40.41261912
120MAP3K80.39486495
121NME10.37836020
122FLT30.37723434
123CDK80.37641162
124EGFR0.35289705
125CDK10.34207601
126MAPK30.33787230
127BRSK20.32933620
128MAPK10.32365495
129SCYL20.32133870
130PAK10.31719704
131MAP2K30.31305429
132TRIB30.30691922
133PAK20.29521558
134MAPK40.28965752
135MAPK140.28275180
136MAPKAPK20.27193723
137PRKCI0.26689447
138STK30.22881565
139BCKDK0.22710829
140KDR0.22048182
141ZAP700.21066289
142CSNK1G10.20929591
143AKT20.20428580

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.15033519
2DNA replication_Homo sapiens_hsa030304.96872412
3Base excision repair_Homo sapiens_hsa034104.69507603
4Fatty acid biosynthesis_Homo sapiens_hsa000613.43321021
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27040001
6Spliceosome_Homo sapiens_hsa030402.94039606
7Nucleotide excision repair_Homo sapiens_hsa034202.77785546
8RNA transport_Homo sapiens_hsa030132.69399230
9Ribosome_Homo sapiens_hsa030102.57412092
10Homologous recombination_Homo sapiens_hsa034402.55817253
11Fanconi anemia pathway_Homo sapiens_hsa034602.14130997
12mRNA surveillance pathway_Homo sapiens_hsa030152.04101569
13Cell cycle_Homo sapiens_hsa041101.95586484
14Sulfur relay system_Homo sapiens_hsa041221.87261260
15Proteasome_Homo sapiens_hsa030501.81462643
16One carbon pool by folate_Homo sapiens_hsa006701.79510038
17RNA polymerase_Homo sapiens_hsa030201.78798719
18p53 signaling pathway_Homo sapiens_hsa041151.77116354
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72614683
20Non-small cell lung cancer_Homo sapiens_hsa052231.69289998
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58747012
22Other glycan degradation_Homo sapiens_hsa005111.53933031
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51554800
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49703301
25Biosynthesis of amino acids_Homo sapiens_hsa012301.49626697
26Folate biosynthesis_Homo sapiens_hsa007901.44740072
27Pyrimidine metabolism_Homo sapiens_hsa002401.43785050
28Vitamin B6 metabolism_Homo sapiens_hsa007501.42567016
29Notch signaling pathway_Homo sapiens_hsa043301.40237557
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38065902
31Pancreatic cancer_Homo sapiens_hsa052121.33959702
32mTOR signaling pathway_Homo sapiens_hsa041501.30331573
33Arginine and proline metabolism_Homo sapiens_hsa003301.25849294
34Circadian rhythm_Homo sapiens_hsa047101.20972725
35Hippo signaling pathway_Homo sapiens_hsa043901.20567245
36Carbon metabolism_Homo sapiens_hsa012001.17976662
37Fatty acid elongation_Homo sapiens_hsa000621.17090280
38Hedgehog signaling pathway_Homo sapiens_hsa043401.14568144
39RNA degradation_Homo sapiens_hsa030181.13504444
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10698808
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08792520
42Primary immunodeficiency_Homo sapiens_hsa053401.03126370
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01310254
44Bladder cancer_Homo sapiens_hsa052191.00678608
45Basal transcription factors_Homo sapiens_hsa030220.99659561
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99565529
47Fructose and mannose metabolism_Homo sapiens_hsa000510.96108552
48Shigellosis_Homo sapiens_hsa051310.95564352
49Oocyte meiosis_Homo sapiens_hsa041140.93160231
50Glioma_Homo sapiens_hsa052140.91550352
51Adherens junction_Homo sapiens_hsa045200.91200131
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.89891881
53Renal cell carcinoma_Homo sapiens_hsa052110.88800400
54TGF-beta signaling pathway_Homo sapiens_hsa043500.87014497
55Non-homologous end-joining_Homo sapiens_hsa034500.85341372
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83227143
57Selenocompound metabolism_Homo sapiens_hsa004500.81285327
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77784007
59Prostate cancer_Homo sapiens_hsa052150.77014897
60Epstein-Barr virus infection_Homo sapiens_hsa051690.75935167
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.75779203
62Hepatitis C_Homo sapiens_hsa051600.74045017
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73706106
64Thyroid cancer_Homo sapiens_hsa052160.71891164
65Viral carcinogenesis_Homo sapiens_hsa052030.71857046
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71499030
67Basal cell carcinoma_Homo sapiens_hsa052170.69754589
68Colorectal cancer_Homo sapiens_hsa052100.69604259
69Wnt signaling pathway_Homo sapiens_hsa043100.68470082
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68374586
71ErbB signaling pathway_Homo sapiens_hsa040120.65621052
72Prion diseases_Homo sapiens_hsa050200.65318774
73Herpes simplex infection_Homo sapiens_hsa051680.65277689
74VEGF signaling pathway_Homo sapiens_hsa043700.64726104
75Lysine degradation_Homo sapiens_hsa003100.64174204
76Acute myeloid leukemia_Homo sapiens_hsa052210.61453346
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59923174
78MicroRNAs in cancer_Homo sapiens_hsa052060.58620539
79Legionellosis_Homo sapiens_hsa051340.58325716
80Proteoglycans in cancer_Homo sapiens_hsa052050.57233035
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57068713
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.57019778
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56693577
84Galactose metabolism_Homo sapiens_hsa000520.55414341
85Influenza A_Homo sapiens_hsa051640.54423130
86Small cell lung cancer_Homo sapiens_hsa052220.54044599
87Chronic myeloid leukemia_Homo sapiens_hsa052200.53693253
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53551485
89Prolactin signaling pathway_Homo sapiens_hsa049170.53179434
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51571925
91Glutathione metabolism_Homo sapiens_hsa004800.50002924
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49649860
93N-Glycan biosynthesis_Homo sapiens_hsa005100.49241317
94Leishmaniasis_Homo sapiens_hsa051400.48827575
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48341327
96Fatty acid metabolism_Homo sapiens_hsa012120.48227827
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.48116056
98Toxoplasmosis_Homo sapiens_hsa051450.46909770
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46424998
100HTLV-I infection_Homo sapiens_hsa051660.46357964
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.46317321
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.45297703
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.44868516
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44711404
105Melanoma_Homo sapiens_hsa052180.43546407
106Antigen processing and presentation_Homo sapiens_hsa046120.41643209
107Purine metabolism_Homo sapiens_hsa002300.41272625
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40958690
109Focal adhesion_Homo sapiens_hsa045100.39956168
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.38834709
111Viral myocarditis_Homo sapiens_hsa054160.33896722
112Systemic lupus erythematosus_Homo sapiens_hsa053220.29371482
113Pentose phosphate pathway_Homo sapiens_hsa000300.29123780
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28585601
115Hepatitis B_Homo sapiens_hsa051610.28423195
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27634278
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27389381
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27323478
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26293965
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23037047
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.23001947
122AMPK signaling pathway_Homo sapiens_hsa041520.22534763
123Insulin signaling pathway_Homo sapiens_hsa049100.21070824
124Tight junction_Homo sapiens_hsa045300.20579325
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20285485
126Measles_Homo sapiens_hsa051620.17803028
127HIF-1 signaling pathway_Homo sapiens_hsa040660.17557402
128B cell receptor signaling pathway_Homo sapiens_hsa046620.17241531
129Endometrial cancer_Homo sapiens_hsa052130.15602840
130Apoptosis_Homo sapiens_hsa042100.15463409
131Pathways in cancer_Homo sapiens_hsa052000.14336821
132Gap junction_Homo sapiens_hsa045400.12450443
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12163060
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11911871

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