HGS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.46881835
2transcription from mitochondrial promoter (GO:0006390)8.17772643
3embryonic process involved in female pregnancy (GO:0060136)7.74537390
4positive regulation of protein homooligomerization (GO:0032464)6.91741190
5regulation of integrin activation (GO:0033623)6.77495106
6replication fork processing (GO:0031297)6.73165152
7establishment of apical/basal cell polarity (GO:0035089)6.43359143
8oxidative demethylation (GO:0070989)6.38320152
9regulation of protein homooligomerization (GO:0032462)6.38018328
10DNA deamination (GO:0045006)6.29242444
11establishment or maintenance of monopolar cell polarity (GO:0061339)5.74835696
12establishment of monopolar cell polarity (GO:0061162)5.74835696
13mitochondrial DNA metabolic process (GO:0032042)5.30291659
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.29974087
15mitotic G1 DNA damage checkpoint (GO:0031571)5.05483512
16poly(A)+ mRNA export from nucleus (GO:0016973)4.82130796
17embryonic placenta development (GO:0001892)4.78890394
18somatic diversification of immune receptors via somatic mutation (GO:0002566)4.76645943
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.76645943
20regulation of translational fidelity (GO:0006450)4.76162664
21cellular response to ATP (GO:0071318)4.75224469
22glutamine family amino acid biosynthetic process (GO:0009084)4.70295575
23DNA strand renaturation (GO:0000733)4.66544964
24negative regulation of protein oligomerization (GO:0032460)4.65607437
25mannose metabolic process (GO:0006013)4.56392718
26negative regulation of fatty acid biosynthetic process (GO:0045717)4.46382300
27mitotic G1/S transition checkpoint (GO:0044819)4.44489603
28COPI coating of Golgi vesicle (GO:0048205)4.44114966
29Golgi transport vesicle coating (GO:0048200)4.44114966
30mRNA cleavage (GO:0006379)4.40959940
31negative regulation of cell cycle arrest (GO:0071157)4.38077072
32G1 DNA damage checkpoint (GO:0044783)4.36397832
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.33781884
34negative regulation of Ras GTPase activity (GO:0034261)4.26730503
35negative regulation of erythrocyte differentiation (GO:0045647)4.21990012
36spliceosomal tri-snRNP complex assembly (GO:0000244)4.19623857
37cellular response to zinc ion (GO:0071294)4.14812405
38positive regulation of protein oligomerization (GO:0032461)4.13225189
39regulation of protein oligomerization (GO:0032459)4.09506484
40viral mRNA export from host cell nucleus (GO:0046784)4.05537049
41protein retention in ER lumen (GO:0006621)4.04654141
42embryonic camera-type eye development (GO:0031076)3.93227163
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90101749
44glial cell migration (GO:0008347)3.87557691
45activation of MAPKKK activity (GO:0000185)3.84496442
46negative regulation of cell size (GO:0045792)3.84487190
47convergent extension (GO:0060026)3.81047774
48sulfur amino acid catabolic process (GO:0000098)3.80468969
49NIK/NF-kappaB signaling (GO:0038061)3.79292933
50apoptotic process involved in morphogenesis (GO:0060561)3.78029027
51positive regulation of developmental pigmentation (GO:0048087)3.73785648
52DNA integration (GO:0015074)3.72373403
53semaphorin-plexin signaling pathway (GO:0071526)3.70786327
54barbed-end actin filament capping (GO:0051016)3.69907058
55formation of translation preinitiation complex (GO:0001731)3.68579538
56face development (GO:0060324)3.67338921
57anatomical structure regression (GO:0060033)3.65856703
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.64909040
59base-excision repair (GO:0006284)3.61577441
60labyrinthine layer development (GO:0060711)3.59921213
61dosage compensation (GO:0007549)3.59396918
62regulation of early endosome to late endosome transport (GO:2000641)3.55425047
63regulation of podosome assembly (GO:0071801)3.55031367
64trophectodermal cell differentiation (GO:0001829)3.54557734
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.52963938
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.51776439
67positive regulation by host of viral transcription (GO:0043923)3.49365476
68histone H4-K12 acetylation (GO:0043983)3.47949886
69UV protection (GO:0009650)3.41799087
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41413647
71signal complex assembly (GO:0007172)3.38940093
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38807943
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38807943
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.38807943
75GDP-mannose metabolic process (GO:0019673)3.33573554
76nodal signaling pathway (GO:0038092)3.33128123
77mitochondrial RNA metabolic process (GO:0000959)3.32044067
78regulation of cell size (GO:0008361)3.31603278
79regulation of cAMP-dependent protein kinase activity (GO:2000479)3.31532010
80regulation of hippo signaling (GO:0035330)3.29931672
81activation of Rac GTPase activity (GO:0032863)3.29688830
82double-strand break repair via nonhomologous end joining (GO:0006303)3.26897105
83non-recombinational repair (GO:0000726)3.26897105
84protein localization to endosome (GO:0036010)3.26439687
85regulation of sister chromatid cohesion (GO:0007063)3.23910927
86regulation of RNA export from nucleus (GO:0046831)3.21671649
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20927179
88positive regulation of receptor recycling (GO:0001921)3.19396200
89alkaloid metabolic process (GO:0009820)3.18410630
90DNA double-strand break processing (GO:0000729)3.18113680
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17613061
92regulation of ARF GTPase activity (GO:0032312)3.16956627
93positive regulation of Cdc42 GTPase activity (GO:0043089)3.16354328
94hypotonic response (GO:0006971)3.14417946
95base-excision repair, AP site formation (GO:0006285)3.13253739
96negative regulation of mRNA processing (GO:0050686)3.13117219
97negative regulation of tumor necrosis factor production (GO:0032720)3.11605809
98negative regulation of heart rate (GO:0010459)3.08801671
99intracellular estrogen receptor signaling pathway (GO:0030520)3.08536358
100stress fiber assembly (GO:0043149)3.03978566
101negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.00715696
102regulation of mitochondrial depolarization (GO:0051900)2.99802153
103basement membrane organization (GO:0071711)2.99033606
104regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.98260457
105hemidesmosome assembly (GO:0031581)2.97014592
106very-low-density lipoprotein particle assembly (GO:0034379)2.96662660
107adherens junction assembly (GO:0034333)2.96605074
108mitotic nuclear envelope reassembly (GO:0007084)2.96351861
109nuclear envelope reassembly (GO:0031468)2.96351861
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95917676
111modulation by symbiont of host cellular process (GO:0044068)2.95775352
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95045628
113regulation of response to reactive oxygen species (GO:1901031)2.94119864
114cell-substrate junction assembly (GO:0007044)2.91767127
115cell-substrate adherens junction assembly (GO:0007045)2.90671777
116focal adhesion assembly (GO:0048041)2.90671777
117positive regulation of DNA repair (GO:0045739)2.90315824
118regulation of posttranscriptional gene silencing (GO:0060147)2.88645019
119regulation of gene silencing by miRNA (GO:0060964)2.88645019
120regulation of gene silencing by RNA (GO:0060966)2.88645019
121synaptic vesicle endocytosis (GO:0048488)2.87254525
122termination of RNA polymerase II transcription (GO:0006369)2.86656905
123pinocytosis (GO:0006907)2.86566598
124negative regulation of chondrocyte differentiation (GO:0032331)2.86056453
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85968494
126N-glycan processing (GO:0006491)2.85098624
127regulation of double-strand break repair (GO:2000779)2.84699158
128regulation of monocyte differentiation (GO:0045655)2.81076439
129modulation by virus of host process (GO:0019054)2.80938551
130positive regulation of nuclease activity (GO:0032075)2.80284191
131response to peptidoglycan (GO:0032494)2.79768956
132positive regulation of histone deacetylation (GO:0031065)2.78397006
133cell-cell junction maintenance (GO:0045217)2.77775302
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75093327
135negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.74749943
136retrograde transport, endosome to Golgi (GO:0042147)2.72533532
137negative regulation of viral release from host cell (GO:1902187)2.71157061
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70671898
139cellular response to virus (GO:0098586)2.69595818
140regulation of glucose import in response to insulin stimulus (GO:2001273)2.67999468
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.67671839
142histone H4 deacetylation (GO:0070933)2.63053803
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62049921
144endoplasmic reticulum unfolded protein response (GO:0030968)2.58231407
145response to muramyl dipeptide (GO:0032495)2.57297012
146pyrimidine-containing compound salvage (GO:0008655)2.55316929
147pyrimidine nucleoside salvage (GO:0043097)2.55316929
148cell volume homeostasis (GO:0006884)2.54856741
149positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51263115
150glucose 6-phosphate metabolic process (GO:0051156)2.49328443
151protein maturation by protein folding (GO:0022417)2.48631633
152regulation of nuclease activity (GO:0032069)2.48084352
153negative regulation of necroptotic process (GO:0060546)2.47609743
154pentose-phosphate shunt (GO:0006098)2.47518272
155snRNA metabolic process (GO:0016073)2.45169457
156glucose catabolic process (GO:0006007)2.45166450
157atrioventricular valve morphogenesis (GO:0003181)2.45136360
158maintenance of protein localization in organelle (GO:0072595)2.44046097
159hyaluronan catabolic process (GO:0030214)2.44030160
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42727957
161positive regulation of odontogenesis (GO:0042482)2.39937899
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39494328
163regulation of necrotic cell death (GO:0010939)2.39053819
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38798988
165ER-nucleus signaling pathway (GO:0006984)2.36764858
166regulation of extracellular matrix disassembly (GO:0010715)2.36316482
167regulation of leukocyte degranulation (GO:0043300)2.36316458
168negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36019719
169maternal placenta development (GO:0001893)2.35886598
170response to laminar fluid shear stress (GO:0034616)2.35830299
171cellular response to unfolded protein (GO:0034620)2.35418996
172regulation of defense response to virus by virus (GO:0050690)2.33276379
173peptidyl-proline hydroxylation (GO:0019511)2.32636183
174endothelial cell chemotaxis (GO:0035767)2.32251287
1753-UTR-mediated mRNA stabilization (GO:0070935)2.31731070
176activation of JUN kinase activity (GO:0007257)2.31477835
177regulation of necroptotic process (GO:0060544)2.30827455
178skin morphogenesis (GO:0043589)2.30450338
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29332882
180actin filament bundle organization (GO:0061572)2.27299800
181actin filament bundle assembly (GO:0051017)2.27299800
182regulation of NFAT protein import into nucleus (GO:0051532)2.26520414
183lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25731895
184endocytic recycling (GO:0032456)2.25513924
185cellular response to topologically incorrect protein (GO:0035967)2.25358232
186embryo implantation (GO:0007566)2.24458763
187proline biosynthetic process (GO:0006561)11.1688474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.33199543
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.14443578
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.70729301
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67039435
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.60669588
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.60669588
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.60669588
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56032214
9LXR_22292898_ChIP-Seq_THP-1_Human2.50512559
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49788973
11VDR_21846776_ChIP-Seq_THP-1_Human2.45243500
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33949919
13KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.31577091
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.31022134
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.22415994
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.18359648
17* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09504005
18POU5F1_16518401_ChIP-PET_MESCs_Mouse2.07548245
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.07395062
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.00630222
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84619142
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82522263
23ZNF263_19887448_ChIP-Seq_K562_Human1.80142802
24TET1_21451524_ChIP-Seq_MESCs_Mouse1.79468031
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78809699
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78488817
27TCF3_18692474_ChIP-Seq_MESCs_Mouse1.76027711
28RACK7_27058665_Chip-Seq_MCF-7_Human1.75465423
29PU.1_20513432_ChIP-Seq_Bcells_Mouse1.70977624
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69040439
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69007753
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68320924
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67468955
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.67169998
35MYC_22102868_ChIP-Seq_BL_Human1.65273395
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65218645
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.62616642
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62499172
39KDM2B_26808549_Chip-Seq_DND41_Human1.58437424
40VDR_24763502_ChIP-Seq_THP-1_Human1.57176775
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56795619
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56129242
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54053600
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53349873
45SMC4_20622854_ChIP-Seq_HELA_Human1.52716935
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50524671
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49847672
48MAF_26560356_Chip-Seq_TH2_Human1.48220530
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.47835923
50MAF_26560356_Chip-Seq_TH1_Human1.47168928
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.47019171
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46388260
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45900098
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45615755
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44997964
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43331984
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39177089
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39058799
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38729478
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38062772
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.37940278
62TP53_22127205_ChIP-Seq_IMR90_Human1.37450578
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.36874775
64ATF3_27146783_Chip-Seq_COLON_Human1.36260647
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36039894
66POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.35513140
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35043831
68UTX_26944678_Chip-Seq_JUKART_Human1.34828513
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.34239438
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34071770
71NCOR1_26117541_ChIP-Seq_K562_Human1.33632873
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.33067892
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32743420
74RARB_24833708_ChIP-Seq_LIVER_Mouse1.32244954
75BCOR_27268052_Chip-Seq_Bcells_Human1.31163307
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30710135
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30128204
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29567551
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29108730
80ETS1_21867929_ChIP-Seq_TH2_Mouse1.28620104
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27243868
82PHF8_20622854_ChIP-Seq_HELA_Human1.26932582
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.26723543
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25993137
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25867551
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.25726408
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24839213
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24744925
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24291611
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24291356
91KDM2B_26808549_Chip-Seq_K562_Human1.24030288
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23301902
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21352003
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21117168
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20777883
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20729805
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20247014
98P68_20966046_ChIP-Seq_HELA_Human1.19466676
99E2F1_20622854_ChIP-Seq_HELA_Human1.19451573
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19078379
101FOXM1_23109430_ChIP-Seq_U2OS_Human1.18881614
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18568553
103* RXR_22158963_ChIP-Seq_LIVER_Mouse1.18198609
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18059966
105SPI1_26923725_Chip-Seq_HPCs_Mouse1.17521472
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17455661
107NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17320251
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16550527
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15956823
110BCL6_27268052_Chip-Seq_Bcells_Human1.15670179
111SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14641912
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14334532
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13424724
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.13000768
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11224208
116TP63_17297297_ChIP-ChIP_HaCaT_Human1.11007827
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10638664
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10432451
119CTCF_27219007_Chip-Seq_Bcells_Human1.10060527
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08519182
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.07769087
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07319478
123TCF7_22412390_ChIP-Seq_EML_Mouse1.07314433
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07070145
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07052844
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.06399324
127CLOCK_20551151_ChIP-Seq_293T_Human1.06266593
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06233304
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06089535
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06014857
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05988870
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05970177
133CTCF_26484167_Chip-Seq_Bcells_Mouse1.05887473
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05844364
135* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05472531
136CTCF_21964334_Chip-Seq_Bcells_Human1.04372898
137* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04246046
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04105580
139RUNX1_27514584_Chip-Seq_MCF-7_Human1.03596208
140FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02885843
141CREB1_26743006_Chip-Seq_LNCaP_Human1.01727247
142* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01427332
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01265002
144TP63_22573176_ChIP-Seq_HFKS_Human1.01261963
145UBF1/2_26484160_Chip-Seq_HMECs_Human1.00934638
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00401757
147STAT1_20625510_ChIP-Seq_HELA_Human0.99529510
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.99386697
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99313123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.01267992
2MP0009278_abnormal_bone_marrow4.88340402
3MP0010030_abnormal_orbit_morphology4.24708087
4MP0005171_absent_coat_pigmentation4.02867594
5MP0004233_abnormal_muscle_weight3.74500927
6MP0003283_abnormal_digestive_organ3.05702945
7MP0005451_abnormal_body_composition2.81951481
8MP0001849_ear_inflammation2.79167532
9MP0002009_preneoplasia2.77623490
10MP0002653_abnormal_ependyma_morphology2.76781810
11MP0008260_abnormal_autophagy2.67947951
12MP0003303_peritoneal_inflammation2.58339206
13MP0004858_abnormal_nervous_system2.51586240
14MP0003436_decreased_susceptibility_to2.48595306
15MP0008995_early_reproductive_senescence2.43769765
16MP0001545_abnormal_hematopoietic_system2.41945085
17MP0005397_hematopoietic_system_phenotyp2.41945085
18MP0002877_abnormal_melanocyte_morpholog2.40546279
19MP0003890_abnormal_embryonic-extraembry2.28265157
20MP0005076_abnormal_cell_differentiation2.25322550
21MP0004133_heterotaxia2.23155466
22MP0003191_abnormal_cellular_cholesterol2.21826172
23MP0010352_gastrointestinal_tract_polyps2.11285281
24MP0008438_abnormal_cutaneous_collagen2.10963880
25MP0002282_abnormal_trachea_morphology2.07392889
26MP0003453_abnormal_keratinocyte_physiol2.02343624
27MP0003172_abnormal_lysosome_physiology2.01426708
28MP0002249_abnormal_larynx_morphology2.00716791
29MP0005058_abnormal_lysosome_morphology1.90237067
30MP0005257_abnormal_intraocular_pressure1.87836319
31MP0000858_altered_metastatic_potential1.85853209
32MP0004947_skin_inflammation1.83772168
33MP0000003_abnormal_adipose_tissue1.82423612
34MP0000678_abnormal_parathyroid_gland1.79265249
35MP0003091_abnormal_cell_migration1.76557041
36MP0001348_abnormal_lacrimal_gland1.70519907
37MP0005174_abnormal_tail_pigmentation1.69976508
38MP0003279_aneurysm1.68849454
39MP0004510_myositis1.68169596
40MP0000751_myopathy1.63834139
41MP0010234_abnormal_vibrissa_follicle1.62986840
42MP0003705_abnormal_hypodermis_morpholog1.57670747
43MP0000579_abnormal_nail_morphology1.55584444
44MP0000371_diluted_coat_color1.54854580
45MP0002269_muscular_atrophy1.54259232
46MP0006072_abnormal_retinal_apoptosis1.52447388
47MP0004185_abnormal_adipocyte_glucose1.52168429
48MP0003786_premature_aging1.51188971
49MP0010094_abnormal_chromosome_stability1.50199235
50MP0005365_abnormal_bile_salt1.49160658
51MP0003329_amyloid_beta_deposits1.48737409
52MP0005085_abnormal_gallbladder_physiolo1.48720174
53MP0008877_abnormal_DNA_methylation1.48281534
54* MP0002086_abnormal_extraembryonic_tissu1.45457308
55MP0004197_abnormal_fetal_growth/weight/1.43510970
56MP0001293_anophthalmia1.40053212
57* MP0002084_abnormal_developmental_patter1.39166449
58MP0009333_abnormal_splenocyte_physiolog1.38121205
59MP0003300_gastrointestinal_ulcer1.36115304
60MP0005375_adipose_tissue_phenotype1.35876612
61MP0005409_darkened_coat_color1.34870652
62MP0000462_abnormal_digestive_system1.32984651
63* MP0001697_abnormal_embryo_size1.30150603
64MP0000639_abnormal_adrenal_gland1.28895045
65* MP0002085_abnormal_embryonic_tissue1.28135190
66MP0002796_impaired_skin_barrier1.27568494
67MP0003045_fibrosis1.23826653
68MP0003656_abnormal_erythrocyte_physiolo1.17258528
69MP0000490_abnormal_crypts_of1.16639197
70MP0001958_emphysema1.16461250
71MP0000750_abnormal_muscle_regeneration1.15981263
72MP0004957_abnormal_blastocyst_morpholog1.15731027
73MP0002419_abnormal_innate_immunity1.15580978
74MP0000470_abnormal_stomach_morphology1.15213765
75MP0000013_abnormal_adipose_tissue1.15114453
76MP0000733_abnormal_muscle_development1.14881174
77MP0002998_abnormal_bone_remodeling1.14385855
78MP0001340_abnormal_eyelid_morphology1.13472964
79MP0005025_abnormal_response_to1.13266295
80MP0001672_abnormal_embryogenesis/_devel1.13048888
81MP0005380_embryogenesis_phenotype1.13048888
82MP0009115_abnormal_fat_cell1.12631113
83MP0001533_abnormal_skeleton_physiology1.12594864
84MP0005666_abnormal_adipose_tissue1.11523221
85MP0003111_abnormal_nucleus_morphology1.11268943
86MP0002111_abnormal_tail_morphology1.10679460
87MP0002933_joint_inflammation1.08599078
88MP0000015_abnormal_ear_pigmentation1.08215762
89* MP0003119_abnormal_digestive_system1.04382851
90MP0004272_abnormal_basement_membrane1.04292365
91MP0002932_abnormal_joint_morphology1.03487272
92MP0003566_abnormal_cell_adhesion1.03305347
93MP0003763_abnormal_thymus_physiology1.02585790
94MP0008932_abnormal_embryonic_tissue1.01859693
95MP0009053_abnormal_anal_canal1.00533578
96MP0000767_abnormal_smooth_muscle0.99952606
97MP0002089_abnormal_postnatal_growth/wei0.99648080
98MP0001873_stomach_inflammation0.99640849
99MP0001730_embryonic_growth_arrest0.97874255
100MP0005000_abnormal_immune_tolerance0.97597928
101MP0003567_abnormal_fetal_cardiomyocyte0.95171833
102MP0009384_cardiac_valve_regurgitation0.94993201
103MP0004264_abnormal_extraembryonic_tissu0.94578353
104* MP0005621_abnormal_cell_physiology0.93307464
105MP0000343_altered_response_to0.93306369
106MP0000747_muscle_weakness0.93283798
107MP0001216_abnormal_epidermal_layer0.91938849
108MP0001324_abnormal_eye_pigmentation0.91192884
109MP0008058_abnormal_DNA_repair0.91128600
110MP0000681_abnormal_thyroid_gland0.90975074
111MP0000350_abnormal_cell_proliferation0.90193102
112MP0000604_amyloidosis0.89725676
113MP0009931_abnormal_skin_appearance0.89612389
114MP0005075_abnormal_melanosome_morpholog0.88619652
115MP0005023_abnormal_wound_healing0.88459214
116MP0000759_abnormal_skeletal_muscle0.86245538
117MP0003755_abnormal_palate_morphology0.85095424
118* MP0002080_prenatal_lethality0.84934548
119MP0004808_abnormal_hematopoietic_stem0.84679924
120MP0004019_abnormal_vitamin_homeostasis0.84561927
121MP0010307_abnormal_tumor_latency0.84235837
122MP0006082_CNS_inflammation0.83951750
123MP0005410_abnormal_fertilization0.83862052
124MP0002060_abnormal_skin_morphology0.83807576
125MP0000685_abnormal_immune_system0.83598929
126MP0003984_embryonic_growth_retardation0.83335565
127MP0003935_abnormal_craniofacial_develop0.82754558
128MP0003806_abnormal_nucleotide_metabolis0.82722848
129MP0003828_pulmonary_edema0.82371537
130MP0005390_skeleton_phenotype0.82184328
131MP0005464_abnormal_platelet_physiology0.81386386
132MP0002019_abnormal_tumor_incidence0.81361900
133MP0002723_abnormal_immune_serum0.80445686
134MP0005266_abnormal_metabolism0.80354214
135MP0005645_abnormal_hypothalamus_physiol0.79391464
136MP0002088_abnormal_embryonic_growth/wei0.78951011
137MP0005508_abnormal_skeleton_morphology0.78619102
138MP0005501_abnormal_skin_physiology0.78552058
139MP0002452_abnormal_antigen_presenting0.78320997
140MP0010155_abnormal_intestine_physiology0.78234189
141MP0002116_abnormal_craniofacial_bone0.78209596
142MP0003448_altered_tumor_morphology0.77809350
143MP0008874_decreased_physiological_sensi0.77703674
144MP0001853_heart_inflammation0.77247511
145MP0002970_abnormal_white_adipose0.76966507
146MP0000762_abnormal_tongue_morphology0.76471062
147MP0002114_abnormal_axial_skeleton0.76142167
148MP0005360_urolithiasis0.75945021
149MP0003075_altered_response_to0.75835730
150MP0003137_abnormal_impulse_conducting0.75523738
151MP0001819_abnormal_immune_cell0.75466726
152MP0001145_abnormal_male_reproductive0.74845093
153MP0002420_abnormal_adaptive_immunity0.73661691
154MP0000467_abnormal_esophagus_morphology0.73540271
155MP0003634_abnormal_glial_cell0.73040731
156MP0009840_abnormal_foam_cell0.72928009
157MP0000516_abnormal_urinary_system0.72838864
158MP0005367_renal/urinary_system_phenotyp0.72838864
159MP0005083_abnormal_biliary_tract0.72730900
160MP0010630_abnormal_cardiac_muscle0.72213681
161MP0004381_abnormal_hair_follicle0.71612489
162MP0000537_abnormal_urethra_morphology0.71259089
163MP0002075_abnormal_coat/hair_pigmentati0.70724973
164MP0001790_abnormal_immune_system0.70145478
165MP0005387_immune_system_phenotype0.70145478
166MP0002405_respiratory_system_inflammati0.70096242
167MP0002148_abnormal_hypersensitivity_rea0.70026893
168MP0003795_abnormal_bone_structure0.69790707
169MP0005670_abnormal_white_adipose0.69120478
170MP0001243_abnormal_dermal_layer0.68180543
171MP0002429_abnormal_blood_cell0.67698454
172MP0002332_abnormal_exercise_endurance0.65816746
173MP0005330_cardiomyopathy0.65085245
174MP0001929_abnormal_gametogenesis0.64757345
175MP0005623_abnormal_meninges_morphology0.63985575

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.18192870
2Pustule (HP:0200039)5.13016774
3Annular pancreas (HP:0001734)5.08325685
4Turricephaly (HP:0000262)5.06763493
5Concave nail (HP:0001598)4.98253225
6Alopecia of scalp (HP:0002293)4.88068410
7Increased IgM level (HP:0003496)4.53775293
8Facial hemangioma (HP:0000329)4.47284966
9Ulnar bowing (HP:0003031)4.44826880
10Rectovaginal fistula (HP:0000143)4.35588443
11Rectal fistula (HP:0100590)4.35588443
12Male infertility (HP:0003251)4.19741433
13Vaginal fistula (HP:0004320)4.06086402
14Poikiloderma (HP:0001029)4.04882368
15Coronal craniosynostosis (HP:0004440)4.04661367
16Intestinal fistula (HP:0100819)3.97866412
17Hypochromic microcytic anemia (HP:0004840)3.94410602
18Tongue fasciculations (HP:0001308)3.94091231
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.93391130
20Short humerus (HP:0005792)3.83801717
21Muscle fibrillation (HP:0010546)3.72767114
22Aplasia/hypoplasia of the humerus (HP:0006507)3.64052355
23Urinary glycosaminoglycan excretion (HP:0003541)3.54581280
24Mucopolysacchariduria (HP:0008155)3.54581280
25Hyperacusis (HP:0010780)3.51676757
26Orthostatic hypotension (HP:0001278)3.48637152
27Upper limb amyotrophy (HP:0009129)3.47104465
28Distal upper limb amyotrophy (HP:0007149)3.47104465
29Broad face (HP:0000283)3.45206546
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.43059652
31Vertebral hypoplasia (HP:0008417)3.43059652
32Distal lower limb amyotrophy (HP:0008944)3.34487599
33Abnormality of the aortic arch (HP:0012303)3.32995662
34Cerebral aneurysm (HP:0004944)3.26785444
35Abnormality of polysaccharide metabolism (HP:0011012)3.25371659
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25371659
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25371659
38Premature rupture of membranes (HP:0001788)3.21600923
39Dysostosis multiplex (HP:0000943)3.20452452
40Congenital hip dislocation (HP:0001374)3.18310057
41Abnormal hemoglobin (HP:0011902)3.17000446
42Diaphragmatic weakness (HP:0009113)3.13257169
43Growth hormone excess (HP:0000845)3.10475467
44Cervical subluxation (HP:0003308)3.09875310
45Anteriorly placed anus (HP:0001545)3.06226668
46Vertebral compression fractures (HP:0002953)3.05518201
47Protrusio acetabuli (HP:0003179)3.04918511
48Dysautonomia (HP:0002459)3.04649140
49Difficulty climbing stairs (HP:0003551)3.03317205
50Albinism (HP:0001022)2.98449456
51Abnormality of male internal genitalia (HP:0000022)2.96720150
52Abnormality of the lower motor neuron (HP:0002366)2.95518216
53Alacrima (HP:0000522)2.89825614
54Thin bony cortex (HP:0002753)2.89738135
55Polycythemia (HP:0001901)2.89284418
56Achilles tendon contracture (HP:0001771)2.87427738
57Large for gestational age (HP:0001520)2.84937945
58Intestinal atresia (HP:0011100)2.84295489
59Stridor (HP:0010307)2.74887074
60Joint stiffness (HP:0001387)2.74559879
61Premature skin wrinkling (HP:0100678)2.74469773
62Increased connective tissue (HP:0009025)2.73558425
63Short chin (HP:0000331)2.71720147
64Obstructive sleep apnea (HP:0002870)2.69336281
65J-shaped sella turcica (HP:0002680)2.69249509
66Hypotrichosis (HP:0001006)2.68192566
67Distal lower limb muscle weakness (HP:0009053)2.67221208
68Broad alveolar ridges (HP:0000187)2.65013419
69Hand muscle atrophy (HP:0009130)2.64814130
70Absent radius (HP:0003974)2.64402180
71Bowing of the arm (HP:0006488)2.63732773
72Bowed forearm bones (HP:0003956)2.63732773
73Hemorrhage of the eye (HP:0011885)2.60865952
74Hypercortisolism (HP:0001578)2.60198247
75Squamous cell carcinoma (HP:0002860)2.60197536
76Choanal stenosis (HP:0000452)2.55722299
77Clumsiness (HP:0002312)2.54964502
78Pancreatic islet-cell hyperplasia (HP:0004510)2.52000021
79Asymmetric septal hypertrophy (HP:0001670)2.51799575
80Absent forearm bone (HP:0003953)2.50429771
81Aplasia involving forearm bones (HP:0009822)2.50429771
82Aplasia of the musculature (HP:0100854)2.48255564
83Abnormality of the Achilles tendon (HP:0005109)2.47230615
84Hamartoma (HP:0010566)2.47181169
85Basal cell carcinoma (HP:0002671)2.45679483
86Selective tooth agenesis (HP:0001592)2.42104973
87Long palpebral fissure (HP:0000637)2.41595704
88Abnormality of liposaccharide metabolism (HP:0010968)2.38572873
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.38572873
90Abnormality of glycolipid metabolism (HP:0010969)2.38572873
91Lower limb amyotrophy (HP:0007210)2.38406580
92Vertebral fusion (HP:0002948)2.33374331
93Atrophic scars (HP:0001075)2.32116578
94Hypotelorism (HP:0000601)2.31414013
95Interstitial pulmonary disease (HP:0006530)2.31109307
96Bulbar palsy (HP:0001283)2.30364207
97Axonal loss (HP:0003447)2.28768560
98Patellar aplasia (HP:0006443)2.27712769
99Bifid uvula (HP:0000193)2.27267592
100Supranuclear gaze palsy (HP:0000605)2.21932916
101Absent thumb (HP:0009777)2.21500446
102Nuclear cataract (HP:0100018)2.21161071
103Abnormality of the distal phalanges of the toes (HP:0010182)2.21080897
104Insomnia (HP:0100785)2.18311480
105Abnormality of the astrocytes (HP:0100707)2.17422635
106Astrocytoma (HP:0009592)2.17422635
107Biconcave vertebral bodies (HP:0004586)2.16954637
108Hypochromic anemia (HP:0001931)2.16556675
109Bilateral sensorineural hearing impairment (HP:0008619)2.15798568
110Hypokinesia (HP:0002375)2.15628426
111Narrow nasal bridge (HP:0000446)2.15202098
112Cellulitis (HP:0100658)2.14495906
113Mitral regurgitation (HP:0001653)2.11791746
114Popliteal pterygium (HP:0009756)2.10099607
115Spinal muscular atrophy (HP:0007269)2.09921604
116Short nail (HP:0001799)2.09102356
117Spinal rigidity (HP:0003306)2.08445458
118Increased cerebral lipofuscin (HP:0011813)2.08074963
119Aplasia/Hypoplasia of the patella (HP:0006498)2.06947784
120Hypertensive crisis (HP:0100735)2.06947302
121Lower limb hyperreflexia (HP:0002395)2.06792971
122Split hand (HP:0001171)2.05767845
123Generalized amyotrophy (HP:0003700)2.05752393
124Capillary hemangiomas (HP:0005306)2.03254260
125Fragile skin (HP:0001030)2.02607650
126Disproportionate tall stature (HP:0001519)2.02547024
127Abnormal respiratory epithelium morphology (HP:0012253)2.02000111
128Abnormal respiratory motile cilium morphology (HP:0005938)2.02000111
129Infertility (HP:0000789)2.01310784
130Decreased lacrimation (HP:0000633)2.01065008
131Gastrointestinal dysmotility (HP:0002579)2.00238456
132Abnormality of the thoracic spine (HP:0100711)1.99878603
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.99864368
134Elbow flexion contracture (HP:0002987)1.98492522
135Short 5th finger (HP:0009237)1.96966831
136Reticulocytosis (HP:0001923)1.95253900
137Atelectasis (HP:0100750)1.94230091
138Cerebral inclusion bodies (HP:0100314)1.93776250
139Loss of speech (HP:0002371)1.93639278
140Flat acetabular roof (HP:0003180)1.92105466
141Easy fatigability (HP:0003388)1.90368209
142Hypertriglyceridemia (HP:0002155)1.89017789
143Blue sclerae (HP:0000592)1.88658853
144IgA deficiency (HP:0002720)1.88237911
145Premature graying of hair (HP:0002216)1.87126705
146Cholecystitis (HP:0001082)1.86692293
147Abnormal gallbladder physiology (HP:0012438)1.86692293
148Neurofibrillary tangles (HP:0002185)1.86324375
149Myocardial infarction (HP:0001658)1.86323942
150Mildly elevated creatine phosphokinase (HP:0008180)1.85574541
151Abnormality of the labia minora (HP:0012880)1.84811847
152Amelogenesis imperfecta (HP:0000705)1.84633237
153Shallow orbits (HP:0000586)1.84076535
154Increased CSF protein (HP:0002922)1.81487731
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80969653
156Myopathic facies (HP:0002058)1.80657875
157Entropion (HP:0000621)1.80497009
158Neuronal loss in central nervous system (HP:0002529)1.79913467
159Upper motor neuron abnormality (HP:0002127)1.79071847
160Increased number of teeth (HP:0011069)1.79027986
161Increased neuronal autofluorescent lipopigment (HP:0002074)1.77215338
162Thoracic kyphosis (HP:0002942)1.77029225
163Eczematoid dermatitis (HP:0000976)1.76476994
164Volvulus (HP:0002580)1.76069230
165Flattened epiphyses (HP:0003071)1.76036291
166Pointed chin (HP:0000307)1.75773798
167Genu recurvatum (HP:0002816)1.73212629
168Aneurysm (HP:0002617)1.71944704
169Supernumerary nipples (HP:0002558)1.70825742
170Ragged-red muscle fibers (HP:0003200)1.70607352
171Fatigue (HP:0012378)1.69165274
172Syringomyelia (HP:0003396)1.66910543
173Spinal cord lesions (HP:0100561)1.66910543
174Wormian bones (HP:0002645)1.64611931
175Trismus (HP:0000211)1.64015382
176Natal tooth (HP:0000695)1.62488151
177Increased IgE level (HP:0003212)1.62487886
178Long toe (HP:0010511)1.62313511
179Testicular atrophy (HP:0000029)1.62097184
180Patellar dislocation (HP:0002999)1.61276326
181Aortic regurgitation (HP:0001659)1.60984358
182Bladder diverticulum (HP:0000015)1.60656849
183Nail dystrophy (HP:0008404)1.60460371
184Emphysema (HP:0002097)1.59918138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.42267971
2DDR25.05669245
3MAPK154.82584082
4MAP3K64.11110139
5MAP3K113.43962338
6IRAK33.21395178
7NME23.11256898
8PINK13.10574138
9TYRO33.03001158
10MATK2.90590081
11FGR2.65993730
12SMG12.65919888
13DAPK12.44274252
14BMX2.36655324
15PDGFRA2.30165096
16UHMK12.27685581
17MST1R2.25955229
18PIM22.24999538
19DYRK1B2.20732045
20PRKD22.09425504
21CSK1.97690119
22EEF2K1.93932220
23MAP2K31.79065827
24LATS21.77321542
25YES11.65807143
26TRIB31.61619250
27EPHB11.57159688
28TTN1.49437264
29ARAF1.46787101
30CDK71.41140069
31MAP3K101.39955668
32TRPM71.36593896
33PKN21.36063751
34CDK61.33636467
35MAP3K31.33090945
36MAP4K11.32261465
37AKT31.26424617
38FGFR41.24748044
39TBK11.23076040
40CDC42BPA1.18571094
41RPS6KC11.15238459
42RPS6KL11.15238459
43PIM11.15124632
44PHKG11.14459800
45PHKG21.14459800
46MAPK111.10564940
47LMTK21.06339304
48MAP3K11.02418956
49GSK3A1.00727853
50ZAP700.99458575
51RPS6KA60.98920905
52SIK30.98443742
53RPS6KA20.98329496
54RIPK10.96245123
55PTK60.89971735
56MAP3K130.89517191
57PDPK10.85900909
58DYRK30.84975542
59MTOR0.84587247
60MET0.83956321
61GRK60.80789944
62MAP3K90.80709889
63EPHA20.79253986
64KDR0.78957864
65NTRK10.78454272
66TAOK20.77401086
67CHEK20.76294826
68IRAK20.74262673
69MAP3K140.73702104
70RPS6KA10.71898939
71TAOK10.71706529
72PRPF4B0.71397985
73PRKAA10.71277526
74MARK30.69587122
75HIPK20.69192530
76IRAK40.68404191
77MOS0.66231596
78LIMK10.65462504
79JAK30.61890477
80PLK10.61822561
81CDK120.60717751
82TYK20.59402776
83STK100.59017681
84RIPK40.58324526
85MAPKAPK30.57860866
86ABL20.57788556
87PTK20.57224412
88MAP3K80.54798399
89ERN10.53508400
90BLK0.52759161
91MAP2K20.51015947
92MAP2K60.50090384
93STK380.48960168
94BRAF0.48597253
95KSR20.47955408
96ILK0.46657649
97MAPK120.46232819
98CAMKK10.44930066
99SIK10.44780178
100CDK40.44614919
101DYRK20.44586669
102PRKD30.43869492
103PRKG20.43854064
104ERBB30.42250079
105RAF10.40927214
106NEK20.40317206
107PDK10.39863694
108CHUK0.39759422
109PRKCI0.39551896
110RPS6KB20.38896305
111LRRK20.38801105
112CDK80.38736799
113MAP3K70.38574699
114PDGFRB0.36929538
115PDK30.35807791
116PDK40.35807791
117CDK20.35509333
118CAMK2G0.34353642
119AURKA0.33456718
120SCYL20.33455945
121RPS6KB10.32172698
122PAK60.31762837
123MAPK10.31300987
124PRKCZ0.29908285
125SIK20.29311443
126ALK0.28992994
127NEK10.28781804
128MAPK40.28429138
129MAPK30.27558299
130ATR0.27326117
131CAMK2B0.26798125
132PAK40.26586342
133MAPKAPK20.25729353
134CSNK2A10.25102586
135CDK150.24966223
136PAK20.24675145
137MAPK100.24464272
138CDK11A0.23995082
139TESK20.23943608
140TNK20.23255590
141STK30.23232192
142LYN0.22510393
143PAK10.22117163
144INSR0.21920808
145CDK180.21410394
146TESK10.21060321
147MARK20.20719399
148MAPK140.20590657
149PRKAA20.19425595
150NTRK20.19385169
151PRKD10.18763962
152EPHB20.17967870
153* EGFR0.16423365
154CDK140.14008016
155CHEK10.13562721

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.20602184
2Base excision repair_Homo sapiens_hsa034104.06728504
3Other glycan degradation_Homo sapiens_hsa005113.79019204
4Mismatch repair_Homo sapiens_hsa034303.60818747
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.71590726
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.45790859
7mTOR signaling pathway_Homo sapiens_hsa041502.44425007
8DNA replication_Homo sapiens_hsa030302.34160020
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29970386
10Notch signaling pathway_Homo sapiens_hsa043302.18669763
11Hippo signaling pathway_Homo sapiens_hsa043902.09377918
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06292227
13Hedgehog signaling pathway_Homo sapiens_hsa043402.05555154
14Arginine and proline metabolism_Homo sapiens_hsa003302.05027534
15Biosynthesis of amino acids_Homo sapiens_hsa012301.97874117
16Circadian rhythm_Homo sapiens_hsa047101.95128049
17Adherens junction_Homo sapiens_hsa045201.88204426
18Sulfur relay system_Homo sapiens_hsa041221.85546125
19Fatty acid metabolism_Homo sapiens_hsa012121.84613656
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77923336
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.70437399
22Bladder cancer_Homo sapiens_hsa052191.68253887
23mRNA surveillance pathway_Homo sapiens_hsa030151.62060523
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57335437
25Osteoclast differentiation_Homo sapiens_hsa043801.53608012
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.53107547
27Arginine biosynthesis_Homo sapiens_hsa002201.51487949
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48196707
29Shigellosis_Homo sapiens_hsa051311.46455870
30p53 signaling pathway_Homo sapiens_hsa041151.45288261
31Fructose and mannose metabolism_Homo sapiens_hsa000511.44768430
32TNF signaling pathway_Homo sapiens_hsa046681.40181289
33RNA transport_Homo sapiens_hsa030131.39597087
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32808138
35Non-small cell lung cancer_Homo sapiens_hsa052231.32782660
36B cell receptor signaling pathway_Homo sapiens_hsa046621.31213603
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.30733744
38VEGF signaling pathway_Homo sapiens_hsa043701.29903794
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28010016
40TGF-beta signaling pathway_Homo sapiens_hsa043501.27990936
41Folate biosynthesis_Homo sapiens_hsa007901.27429415
42Pentose phosphate pathway_Homo sapiens_hsa000301.26572575
43Nucleotide excision repair_Homo sapiens_hsa034201.25462394
44Apoptosis_Homo sapiens_hsa042101.25261686
45Lysine degradation_Homo sapiens_hsa003101.24091836
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.21397778
47Spliceosome_Homo sapiens_hsa030401.15656067
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.15433145
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15285571
50Basal cell carcinoma_Homo sapiens_hsa052171.14530372
51Hepatitis C_Homo sapiens_hsa051601.12697135
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10322227
53Toxoplasmosis_Homo sapiens_hsa051451.09181428
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.08132426
55Wnt signaling pathway_Homo sapiens_hsa043101.06776429
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05585842
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05537952
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02872774
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01442355
60Leishmaniasis_Homo sapiens_hsa051401.01294060
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97678642
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97568464
63Oocyte meiosis_Homo sapiens_hsa041140.97182035
64Vibrio cholerae infection_Homo sapiens_hsa051100.95756908
65Colorectal cancer_Homo sapiens_hsa052100.95713996
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93405699
67Influenza A_Homo sapiens_hsa051640.92875367
68Dorso-ventral axis formation_Homo sapiens_hsa043200.91536986
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.91354504
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.90687523
71Tuberculosis_Homo sapiens_hsa051520.89779431
72AMPK signaling pathway_Homo sapiens_hsa041520.88283338
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87155465
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86310611
75Chronic myeloid leukemia_Homo sapiens_hsa052200.86040457
76Glioma_Homo sapiens_hsa052140.84138389
77Galactose metabolism_Homo sapiens_hsa000520.83431584
78Pertussis_Homo sapiens_hsa051330.83184716
79Tight junction_Homo sapiens_hsa045300.82383859
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.81733081
81Herpes simplex infection_Homo sapiens_hsa051680.81392151
82Cell cycle_Homo sapiens_hsa041100.80867883
83Amoebiasis_Homo sapiens_hsa051460.80733730
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.79802260
85GnRH signaling pathway_Homo sapiens_hsa049120.79430260
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78239098
87N-Glycan biosynthesis_Homo sapiens_hsa005100.76235584
88Insulin signaling pathway_Homo sapiens_hsa049100.76037847
89HTLV-I infection_Homo sapiens_hsa051660.73436182
90ErbB signaling pathway_Homo sapiens_hsa040120.72074455
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71898560
92Legionellosis_Homo sapiens_hsa051340.70479377
93Acute myeloid leukemia_Homo sapiens_hsa052210.70441998
94Malaria_Homo sapiens_hsa051440.70433907
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69416750
96MicroRNAs in cancer_Homo sapiens_hsa052060.69082512
97Fanconi anemia pathway_Homo sapiens_hsa034600.68444814
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.67947425
99Gap junction_Homo sapiens_hsa045400.67869480
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67380253
101Synaptic vesicle cycle_Homo sapiens_hsa047210.66158383
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64517843
103Viral myocarditis_Homo sapiens_hsa054160.64453899
104Choline metabolism in cancer_Homo sapiens_hsa052310.63577901
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63576321
106Prolactin signaling pathway_Homo sapiens_hsa049170.63103332
107Epstein-Barr virus infection_Homo sapiens_hsa051690.62833265
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62778533
109Renal cell carcinoma_Homo sapiens_hsa052110.60445000
110Inositol phosphate metabolism_Homo sapiens_hsa005620.60153911
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60133898
112Insulin resistance_Homo sapiens_hsa049310.59380246
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57992873
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57348422
115ECM-receptor interaction_Homo sapiens_hsa045120.56980143
116Endometrial cancer_Homo sapiens_hsa052130.56055020
117T cell receptor signaling pathway_Homo sapiens_hsa046600.56050958
118Selenocompound metabolism_Homo sapiens_hsa004500.52804253
119Proteoglycans in cancer_Homo sapiens_hsa052050.52637817
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52242187
121Small cell lung cancer_Homo sapiens_hsa052220.50462660
122Measles_Homo sapiens_hsa051620.49812757
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.49325320
124Sphingolipid metabolism_Homo sapiens_hsa006000.49015461
125Fat digestion and absorption_Homo sapiens_hsa049750.48187627
126Viral carcinogenesis_Homo sapiens_hsa052030.47465067
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47118934
128* Phagosome_Homo sapiens_hsa041450.46312603
129Lysosome_Homo sapiens_hsa041420.46215130
130Homologous recombination_Homo sapiens_hsa034400.44968911
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44763046
132Thyroid cancer_Homo sapiens_hsa052160.44714966
133Glutathione metabolism_Homo sapiens_hsa004800.44220747
134Focal adhesion_Homo sapiens_hsa045100.38225586
135Mineral absorption_Homo sapiens_hsa049780.37470282
136Estrogen signaling pathway_Homo sapiens_hsa049150.33397284
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32471949
138Glycerolipid metabolism_Homo sapiens_hsa005610.32271238
139MAPK signaling pathway_Homo sapiens_hsa040100.32136757
140* Endocytosis_Homo sapiens_hsa041440.31575022
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29945243
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.29772277
143Glucagon signaling pathway_Homo sapiens_hsa049220.28389988
144Pancreatic cancer_Homo sapiens_hsa052120.26703299
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26369682
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26226515
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25238727
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24553300
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23587512
150HIF-1 signaling pathway_Homo sapiens_hsa040660.22165992
151Hepatitis B_Homo sapiens_hsa051610.21917628
152Prion diseases_Homo sapiens_hsa050200.21106931
153Salmonella infection_Homo sapiens_hsa051320.18981870
154Carbon metabolism_Homo sapiens_hsa012000.16341591
155Steroid biosynthesis_Homo sapiens_hsa001000.16082551
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.14893836

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