HHAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.96502112
2axonemal dynein complex assembly (GO:0070286)8.52470731
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.35639468
4cilium movement (GO:0003341)7.49063751
5epithelial cilium movement (GO:0003351)7.21714167
6axoneme assembly (GO:0035082)5.59395738
7protein K11-linked deubiquitination (GO:0035871)5.49233194
8motile cilium assembly (GO:0044458)5.39456828
9regulation of acrosome reaction (GO:0060046)4.92467855
10regulation of cilium movement (GO:0003352)4.69446504
11superoxide anion generation (GO:0042554)4.36059278
12amyloid precursor protein catabolic process (GO:0042987)4.19546577
13retinal cone cell development (GO:0046549)4.17123033
14piRNA metabolic process (GO:0034587)4.11967934
15regulation of timing of cell differentiation (GO:0048505)3.96412100
16thyroid hormone metabolic process (GO:0042403)3.91389022
17regulation of female gonad development (GO:2000194)3.87059438
18protein localization to cilium (GO:0061512)3.81387430
19left/right pattern formation (GO:0060972)3.78326505
20cilium morphogenesis (GO:0060271)3.77363417
21positive regulation of gastrulation (GO:2000543)3.76161859
22carnitine metabolic process (GO:0009437)3.72111675
23mesenchymal cell differentiation involved in kidney development (GO:0072161)3.71670326
24mesenchymal cell differentiation involved in renal system development (GO:2001012)3.71670326
25paraxial mesoderm development (GO:0048339)3.71478675
26meiotic cell cycle (GO:0051321)3.71163117
27angiogenesis involved in wound healing (GO:0060055)3.70256009
28intraciliary transport (GO:0042073)3.59556329
29G-protein coupled receptor internalization (GO:0002031)3.46282796
30regulation of development, heterochronic (GO:0040034)3.44774424
31female gonad development (GO:0008585)3.42712758
32thyroid hormone generation (GO:0006590)3.40103582
33cilium organization (GO:0044782)3.39813320
34multicellular organism reproduction (GO:0032504)3.32968109
35regulation of steroid hormone biosynthetic process (GO:0090030)3.29092346
36regulation of germinal center formation (GO:0002634)3.26322412
37amino-acid betaine metabolic process (GO:0006577)3.26203026
38cilium assembly (GO:0042384)3.25454229
39cell morphogenesis involved in neuron differentiation (GO:0048667)3.17751608
40negative regulation of keratinocyte proliferation (GO:0010839)3.14082181
41righting reflex (GO:0060013)3.13828314
42negative regulation of homotypic cell-cell adhesion (GO:0034111)3.09533877
43fibroblast migration (GO:0010761)3.08687259
44negative regulation of cAMP-mediated signaling (GO:0043951)3.07938738
45phospholipid scrambling (GO:0017121)3.05332218
46microtubule depolymerization (GO:0007019)3.04324624
47pyrimidine-containing compound transmembrane transport (GO:0072531)3.03879310
48germinal center formation (GO:0002467)3.02447239
49positive regulation of interleukin-1 beta secretion (GO:0050718)3.01503155
50microtubule bundle formation (GO:0001578)2.99305947
51detection of other organism (GO:0098543)2.98358688
52DNA integration (GO:0015074)2.98111616
53energy homeostasis (GO:0097009)2.97792116
54lung epithelium development (GO:0060428)2.97191973
55negative regulation of circadian rhythm (GO:0042754)2.96485259
56primary alcohol catabolic process (GO:0034310)2.96019337
57pyrimidine dimer repair (GO:0006290)2.94136507
58DNA strand renaturation (GO:0000733)2.93956206
59histone H2B ubiquitination (GO:0033523)2.93954949
60secondary metabolite biosynthetic process (GO:0044550)2.93622803
61cranial nerve morphogenesis (GO:0021602)2.92591179
62membrane protein intracellular domain proteolysis (GO:0031293)2.92149078
63cell differentiation involved in metanephros development (GO:0072202)2.87262804
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.87231269
65centriole assembly (GO:0098534)2.84904149
66superoxide metabolic process (GO:0006801)2.84640285
67dendritic cell chemotaxis (GO:0002407)2.82712427
68protein K48-linked deubiquitination (GO:0071108)2.80953181
69melanin biosynthetic process (GO:0042438)2.79994713
70detection of bacterium (GO:0016045)2.79369846
71myoblast fusion (GO:0007520)2.77242562
72cellular component assembly involved in morphogenesis (GO:0010927)2.75547718
73adult feeding behavior (GO:0008343)2.75275363
74serotonin receptor signaling pathway (GO:0007210)2.74484007
75positive regulation of interleukin-1 secretion (GO:0050716)2.74005113
76regulation of Cdc42 GTPase activity (GO:0043088)2.73960779
77regulation of memory T cell differentiation (GO:0043380)2.73219232
78positive regulation of uterine smooth muscle contraction (GO:0070474)2.72889134
79microtubule severing (GO:0051013)2.72510636
80striated muscle atrophy (GO:0014891)2.72129274
81cell projection assembly (GO:0030031)2.70063964
82negative regulation of hormone biosynthetic process (GO:0032353)2.69862019
83kinetochore assembly (GO:0051382)2.69473004
84spindle assembly involved in mitosis (GO:0090307)2.69240485
85regulation of interleukin-8 secretion (GO:2000482)2.68843834
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.67317143
87lens fiber cell development (GO:0070307)2.66470676
88ear development (GO:0043583)2.66266307
89sphingomyelin metabolic process (GO:0006684)2.66149096
90regulation of platelet aggregation (GO:0090330)2.65628245
91adenosine metabolic process (GO:0046085)2.64588758
92ventricular system development (GO:0021591)2.63363587
93cell proliferation in forebrain (GO:0021846)2.62867883
94inner ear receptor stereocilium organization (GO:0060122)2.62846014
95protein heterotetramerization (GO:0051290)2.61956691
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60661737
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.60661737
98regulation of translation, ncRNA-mediated (GO:0045974)2.60661737
99replicative senescence (GO:0090399)2.59232761
100regulation of microtubule-based movement (GO:0060632)2.58980200
101startle response (GO:0001964)2.58917036
102lymphoid progenitor cell differentiation (GO:0002320)2.58607736
103response to X-ray (GO:0010165)2.58535982
104organic cation transport (GO:0015695)2.58486021
105auditory receptor cell stereocilium organization (GO:0060088)2.58305323
106filopodium assembly (GO:0046847)2.57762522
107regulation of interleukin-1 beta secretion (GO:0050706)2.57631385
108vitamin transmembrane transport (GO:0035461)2.57421576
109positive regulation of cellular amide metabolic process (GO:0034250)2.56787682
110mesenchymal cell differentiation (GO:0048762)2.55261705
111amyloid precursor protein metabolic process (GO:0042982)2.54468758
112glycerophospholipid catabolic process (GO:0046475)2.53358986
113G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.52900292
114negative regulation of hormone metabolic process (GO:0032351)2.52816881
115oocyte development (GO:0048599)2.51358312
116ceramide catabolic process (GO:0046514)2.51183965
117cell-cell junction maintenance (GO:0045217)2.50541370
118centriole replication (GO:0007099)2.50090148
119reproduction (GO:0000003)2.50045786
120single fertilization (GO:0007338)2.49887615
121melanin metabolic process (GO:0006582)2.49584400
122regulation of appetite (GO:0032098)2.49070840
123dendritic cell migration (GO:0036336)2.48634001
124pharyngeal system development (GO:0060037)2.48396570
125negative regulation of interleukin-8 production (GO:0032717)2.47801097
126head development (GO:0060322)2.47678209
127extracellular negative regulation of signal transduction (GO:1900116)2.46902808
128extracellular regulation of signal transduction (GO:1900115)2.46902808
129glomerular epithelial cell development (GO:0072310)2.46538361
130establishment of planar polarity (GO:0001736)2.46271534
131establishment of tissue polarity (GO:0007164)2.46271534
132daunorubicin metabolic process (GO:0044597)2.45983934
133polyketide metabolic process (GO:0030638)2.45983934
134doxorubicin metabolic process (GO:0044598)2.45983934
135regulation of integrin-mediated signaling pathway (GO:2001044)2.45914580
136diterpenoid biosynthetic process (GO:0016102)2.45849533
137left/right axis specification (GO:0070986)2.45307023
138preassembly of GPI anchor in ER membrane (GO:0016254)2.43888626
139androgen biosynthetic process (GO:0006702)2.43534266
140omega-hydroxylase P450 pathway (GO:0097267)2.43241651
141limb bud formation (GO:0060174)2.41890749
142nucleotide transmembrane transport (GO:1901679)2.41570822
143negative regulation of myoblast differentiation (GO:0045662)2.41185969
144positive regulation of embryonic development (GO:0040019)2.40998818
145sympathetic nervous system development (GO:0048485)2.40816843
146glucosamine-containing compound catabolic process (GO:1901072)2.40004635
147photoreceptor cell maintenance (GO:0045494)2.39662181
148modulation by virus of host process (GO:0019054)2.39492962
149positive regulation of smoothened signaling pathway (GO:0045880)2.38973864
150ganglion development (GO:0061548)2.38730680
151syncytium formation (GO:0006949)2.38610940
152sperm motility (GO:0030317)2.38575125
153glomerular basement membrane development (GO:0032836)2.38452135
154mesonephros development (GO:0001823)2.35908360
155negative regulation of T-helper cell differentiation (GO:0045623)2.35506991
156negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35506991
157microtubule-based movement (GO:0007018)2.35497317
158detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35434571
159reflex (GO:0060004)2.35417976
160dorsal/ventral neural tube patterning (GO:0021904)2.35391308
161neuron fate determination (GO:0048664)2.35209268
162syncytium formation by plasma membrane fusion (GO:0000768)2.35175792
163cornea development in camera-type eye (GO:0061303)2.34419866
164histone H3-K36 demethylation (GO:0070544)2.33687982
165sulfate transport (GO:0008272)2.33073826
166heparan sulfate proteoglycan metabolic process (GO:0030201)2.32744822
167Golgi to endosome transport (GO:0006895)2.32720881
168regulation of keratinocyte proliferation (GO:0010837)2.32361227
169activation of Rac GTPase activity (GO:0032863)2.31447638
170synapsis (GO:0007129)2.31351323
171dentate gyrus development (GO:0021542)2.30599365
172kidney morphogenesis (GO:0060993)2.30210522
173embryonic camera-type eye development (GO:0031076)2.29975821
174regulation of hormone biosynthetic process (GO:0046885)2.29796828
175sphingoid metabolic process (GO:0046519)2.29666378
176exogenous drug catabolic process (GO:0042738)2.29494007
177sulfate transmembrane transport (GO:1902358)2.29388978
178negative regulation of mast cell activation (GO:0033004)2.29325605
179face development (GO:0060324)2.28332272
180positive regulation of interleukin-1 beta production (GO:0032731)2.28202514
181cell differentiation involved in kidney development (GO:0061005)2.28055070
182regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.25425852
183negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.24066623
184facial nerve structural organization (GO:0021612)2.22652485
185positive regulation of CREB transcription factor activity (GO:0032793)2.22634546
186positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.21942907
187negative regulation of stem cell proliferation (GO:2000647)2.21303584
188positive regulation of protein kinase C signaling (GO:0090037)2.21241590
189keratinocyte development (GO:0003334)2.21029688
190postsynaptic membrane organization (GO:0001941)2.20395231
191response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20123971
192response to host immune response (GO:0052572)2.20123971
193positive regulation of interleukin-8 secretion (GO:2000484)2.19795892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.25934329
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.45434533
3* GBX2_23144817_ChIP-Seq_PC3_Human3.41134405
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.14930410
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.13607903
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06605328
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00691035
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.87518392
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80603140
10TP53_16413492_ChIP-PET_HCT116_Human2.72307598
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.70707725
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.69874696
13EZH2_22144423_ChIP-Seq_EOC_Human2.56947395
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.54326883
15* NFE2_27457419_Chip-Seq_LIVER_Mouse2.50572899
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41757588
17IGF1R_20145208_ChIP-Seq_DFB_Human2.38393314
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.31947924
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.30706376
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.22341713
21* EZH2_27294783_Chip-Seq_NPCs_Mouse2.21386401
22AHR_22903824_ChIP-Seq_MCF-7_Human2.20467414
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09977971
24ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09959558
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.07514102
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05965745
27* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.03115380
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.03080208
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00434794
30* NANOG_18555785_Chip-Seq_ESCs_Mouse1.99209292
31* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.98274926
32* STAT3_18555785_Chip-Seq_ESCs_Mouse1.96645641
33* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.95481460
34* P53_22387025_ChIP-Seq_ESCs_Mouse1.92858091
35* E2F1_18555785_Chip-Seq_ESCs_Mouse1.91808130
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.91045150
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89417288
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.88598638
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87999478
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.86946478
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85834974
42* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.85245568
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.83710374
44* NMYC_18555785_Chip-Seq_ESCs_Mouse1.82447042
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81262162
46* CMYC_18555785_Chip-Seq_ESCs_Mouse1.78095132
47* P300_18555785_Chip-Seq_ESCs_Mouse1.77960630
48TAF15_26573619_Chip-Seq_HEK293_Human1.76074806
49* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.75042216
50* OCT4_18555785_Chip-Seq_ESCs_Mouse1.74611044
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.74271132
52CJUN_26792858_Chip-Seq_BT549_Human1.71960270
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71713036
54RNF2_27304074_Chip-Seq_NSC_Mouse1.70019272
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68655773
56* ZFX_18555785_Chip-Seq_ESCs_Mouse1.68534324
57* SOX2_18555785_Chip-Seq_ESCs_Mouse1.65591432
58* P300_19829295_ChIP-Seq_ESCs_Human1.64345337
59* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.63921453
60* PU1_27457419_Chip-Seq_LIVER_Mouse1.63537443
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.61051220
62* KLF4_18555785_Chip-Seq_ESCs_Mouse1.60722280
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.58888680
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58070263
65* DROSHA_22980978_ChIP-Seq_HELA_Human1.57856180
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57702019
67* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.57447390
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56654997
69* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56208249
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56088445
71* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55802319
72* CTCF_18555785_Chip-Seq_ESCs_Mouse1.55643442
73* CRX_20693478_ChIP-Seq_RETINA_Mouse1.55086598
74* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.53675379
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53573304
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53475046
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.52221162
78* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50830688
79* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.49734414
80* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48988968
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46291537
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46159551
83VDR_22108803_ChIP-Seq_LS180_Human1.45813439
84AR_25329375_ChIP-Seq_VCAP_Human1.45680751
85* TP63_23658742_ChIP-Seq_EP156T_Human1.45299776
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.45163692
87* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.43825803
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.42680581
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42179006
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41242750
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40661496
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38640695
93BCAT_22108803_ChIP-Seq_LS180_Human1.37035907
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.36792083
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33671653
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33671653
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.33345617
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32862838
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31856368
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29852029
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29821177
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28597200
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27891554
104TCF4_22108803_ChIP-Seq_LS180_Human1.27544445
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27038854
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27038854
107FUS_26573619_Chip-Seq_HEK293_Human1.27033969
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26895630
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26853510
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26727217
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26465488
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26140004
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26140004
114EWS_26573619_Chip-Seq_HEK293_Human1.24744245
115* EZH2_27294783_Chip-Seq_ESCs_Mouse1.23638612
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23524359
117ER_23166858_ChIP-Seq_MCF-7_Human1.22890068
118* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22618271
119ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22363327
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22008972
121CBP_20019798_ChIP-Seq_JUKART_Human1.22008972
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22006839
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19817821
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19537149
125* RNF2_27304074_Chip-Seq_ESCs_Mouse1.19368855
126AR_21572438_ChIP-Seq_LNCaP_Human1.18672152
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18663695
128* TP53_18474530_ChIP-ChIP_U2OS_Human1.18056340
129KDM2B_26808549_Chip-Seq_REH_Human1.15279209
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14908506
131* STAT3_23295773_ChIP-Seq_U87_Human1.14470188
132CDX2_22108803_ChIP-Seq_LS180_Human1.14015883
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12910307
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12768171
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12187687
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11928836
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11859559
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10794179
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10466476
140BRD4_25478319_ChIP-Seq_HGPS_Human1.07705967
141* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07593919
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.07240172
143RUNX2_22187159_ChIP-Seq_PCA_Human1.06841979
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06569444
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06245497
146* TCF4_23295773_ChIP-Seq_U87_Human1.05133554
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03346025
148FOXA2_19822575_ChIP-Seq_HepG2_Human1.01622285
149RXR_22108803_ChIP-Seq_LS180_Human1.00858745
150GATA3_21878914_ChIP-Seq_MCF-7_Human1.00091590
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.99782402
152FOXA1_25552417_ChIP-Seq_VCAP_Human0.99631082
153* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95966715
154ZNF274_21170338_ChIP-Seq_K562_Hela0.93130853
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91017545
156GATA4_25053715_ChIP-Seq_YYC3_Human0.90004034
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89693368
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89152475
159SOX2_20726797_ChIP-Seq_SW620_Human0.86302154
160Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85375818
161FLI1_21867929_ChIP-Seq_TH2_Mouse0.85039043
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83337145
163GATA3_24758297_ChIP-Seq_MCF-7_Human0.83081129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.85930747
2MP0008875_abnormal_xenobiotic_pharmacok4.61179351
3MP0001188_hyperpigmentation4.35090641
4MP0000566_synostosis4.17551719
5MP0010030_abnormal_orbit_morphology4.04177754
6MP0002102_abnormal_ear_morphology3.82095734
7MP0006292_abnormal_olfactory_placode3.52142892
8MP0005408_hypopigmentation3.44961663
9MP0009780_abnormal_chondrocyte_physiolo3.14911573
10MP0002277_abnormal_respiratory_mucosa2.65467596
11MP0005645_abnormal_hypothalamus_physiol2.53054192
12MP0003136_yellow_coat_color2.47688075
13MP0003718_maternal_effect2.34030250
14MP0003941_abnormal_skin_development2.31610799
15MP0001986_abnormal_taste_sensitivity2.27827297
16MP0003195_calcinosis2.27278810
17MP0005379_endocrine/exocrine_gland_phen2.24847400
18MP0005646_abnormal_pituitary_gland2.14321383
19MP0003950_abnormal_plasma_membrane2.13671011
20MP0002249_abnormal_larynx_morphology2.07597061
21MP0004381_abnormal_hair_follicle2.07153377
22MP0005409_darkened_coat_color2.06774905
23MP0005451_abnormal_body_composition2.06529761
24MP0010678_abnormal_skin_adnexa2.03129875
25MP0005395_other_phenotype2.00709451
26MP0004043_abnormal_pH_regulation1.98412482
27MP0008058_abnormal_DNA_repair1.96528214
28MP0004272_abnormal_basement_membrane1.94206587
29MP0002168_other_aberrant_phenotype1.91970524
30MP0000049_abnormal_middle_ear1.86160975
31MP0002653_abnormal_ependyma_morphology1.83522903
32MP0000015_abnormal_ear_pigmentation1.82924178
33MP0003724_increased_susceptibility_to1.81811033
34MP0005171_absent_coat_pigmentation1.79634941
35MP0003787_abnormal_imprinting1.79118957
36MP0000383_abnormal_hair_follicle1.78563308
37MP0002139_abnormal_hepatobiliary_system1.73074166
38MP0005503_abnormal_tendon_morphology1.68215711
39MP0008995_early_reproductive_senescence1.64279426
40MP0006054_spinal_hemorrhage1.62718077
41MP0009697_abnormal_copulation1.60284305
42MP0005257_abnormal_intraocular_pressure1.59886915
43MP0002160_abnormal_reproductive_system1.57605977
44MP0000569_abnormal_digit_pigmentation1.56780509
45MP0005360_urolithiasis1.55262676
46MP0005174_abnormal_tail_pigmentation1.54545152
47MP0000026_abnormal_inner_ear1.54338100
48MP0002132_abnormal_respiratory_system1.53520538
49MP0010386_abnormal_urinary_bladder1.50666107
50MP0002938_white_spotting1.48878027
51MP0001324_abnormal_eye_pigmentation1.48641468
52MP0000579_abnormal_nail_morphology1.47228462
53MP0001346_abnormal_lacrimal_gland1.47143779
54MP0005058_abnormal_lysosome_morphology1.45997470
55MP0002876_abnormal_thyroid_physiology1.41522278
56MP0002163_abnormal_gland_morphology1.40967894
57MP0000678_abnormal_parathyroid_gland1.39952198
58MP0001835_abnormal_antigen_presentation1.37242643
59MP0000613_abnormal_salivary_gland1.30722735
60MP0009250_abnormal_appendicular_skeleto1.29867244
61MP0004742_abnormal_vestibular_system1.28534918
62MP0003045_fibrosis1.28427322
63MP0008961_abnormal_basal_metabolism1.28355478
64MP0004133_heterotaxia1.25586723
65MP0003938_abnormal_ear_development1.25347146
66MP0001299_abnormal_eye_distance/1.24344345
67MP0002095_abnormal_skin_pigmentation1.24283683
68MP0002177_abnormal_outer_ear1.20098515
69MP0002396_abnormal_hematopoietic_system1.19327713
70MP0008260_abnormal_autophagy1.19325502
71MP0002928_abnormal_bile_duct1.18709315
72MP0000647_abnormal_sebaceous_gland1.17906895
73MP0000631_abnormal_neuroendocrine_gland1.17737804
74MP0005387_immune_system_phenotype1.16418418
75MP0001790_abnormal_immune_system1.16418418
76MP0002638_abnormal_pupillary_reflex1.16118983
77MP0000681_abnormal_thyroid_gland1.14949613
78MP0003191_abnormal_cellular_cholesterol1.14303266
79MP0005389_reproductive_system_phenotype1.12953631
80MP0002735_abnormal_chemical_nociception1.08413902
81MP0003252_abnormal_bile_duct1.06049817
82MP0005670_abnormal_white_adipose1.05937616
83MP0002108_abnormal_muscle_morphology1.05718613
84MP0008789_abnormal_olfactory_epithelium1.05277664
85MP0005197_abnormal_uvea_morphology1.04832960
86MP0002138_abnormal_hepatobiliary_system1.03541531
87MP0005623_abnormal_meninges_morphology1.03234629
88MP0003937_abnormal_limbs/digits/tail_de1.03153858
89MP0000462_abnormal_digestive_system1.02310726
90MP0009785_altered_susceptibility_to1.01547012
91MP0002148_abnormal_hypersensitivity_rea1.01088648
92MP0005075_abnormal_melanosome_morpholog1.00228660
93MP0002233_abnormal_nose_morphology0.99733145
94MP0006072_abnormal_retinal_apoptosis0.99631463
95MP0005671_abnormal_response_to0.99429836
96MP0003566_abnormal_cell_adhesion0.99173668
97MP0004084_abnormal_cardiac_muscle0.98767291
98MP0004019_abnormal_vitamin_homeostasis0.98108449
99MP0000733_abnormal_muscle_development0.97707983
100MP0003315_abnormal_perineum_morphology0.96968153
101MP0004782_abnormal_surfactant_physiolog0.96127271
102MP0002098_abnormal_vibrissa_morphology0.95971062
103MP0001963_abnormal_hearing_physiology0.95841119
104MP0001879_abnormal_lymphatic_vessel0.95077139
105MP0008438_abnormal_cutaneous_collagen0.94718059
106MP0002092_abnormal_eye_morphology0.92702176
107MP0002089_abnormal_postnatal_growth/wei0.91809175
108MP0009384_cardiac_valve_regurgitation0.90536506
109MP0001119_abnormal_female_reproductive0.90520711
110MP0000470_abnormal_stomach_morphology0.90445037
111MP0000490_abnormal_crypts_of0.89549025
112MP0002896_abnormal_bone_mineralization0.89299660
113MP0005248_abnormal_Harderian_gland0.88859809
114MP0001186_pigmentation_phenotype0.88577333
115MP0001756_abnormal_urination0.87438126
116MP0003942_abnormal_urinary_system0.87112753
117MP0003786_premature_aging0.86515659
118MP0005391_vision/eye_phenotype0.84888947
119MP0001929_abnormal_gametogenesis0.84800317
120MP0004134_abnormal_chest_morphology0.83349481
121MP0002909_abnormal_adrenal_gland0.82543643
122MP0000639_abnormal_adrenal_gland0.81989601
123MP0000372_irregular_coat_pigmentation0.81969252
124MP0002116_abnormal_craniofacial_bone0.81874349
125MP0001293_anophthalmia0.81562352
126MP0001486_abnormal_startle_reflex0.81546650
127MP0000003_abnormal_adipose_tissue0.81162334
128MP0005310_abnormal_salivary_gland0.80922717
129MP0000427_abnormal_hair_cycle0.80733905
130MP0000762_abnormal_tongue_morphology0.80690700
131MP0002751_abnormal_autonomic_nervous0.79539663
132MP0005508_abnormal_skeleton_morphology0.79490548
133MP0000432_abnormal_head_morphology0.78977744
134MP0005253_abnormal_eye_physiology0.78929866
135MP0006276_abnormal_autonomic_nervous0.78590242
136MP0008775_abnormal_heart_ventricle0.77210771
137MP0002136_abnormal_kidney_physiology0.77071624
138MP0003755_abnormal_palate_morphology0.76889899
139MP0010234_abnormal_vibrissa_follicle0.76061401
140MP0005195_abnormal_posterior_eye0.75990947
141MP0002090_abnormal_vision0.75719598
142MP0002419_abnormal_innate_immunity0.74582254
143MP0002234_abnormal_pharynx_morphology0.74246941
144MP0005023_abnormal_wound_healing0.74038547
145MP0002933_joint_inflammation0.73648695
146MP0003091_abnormal_cell_migration0.73598655
147MP0005499_abnormal_olfactory_system0.73386137
148MP0005394_taste/olfaction_phenotype0.73386137
149MP0002135_abnormal_kidney_morphology0.73007930
150MP0001984_abnormal_olfaction0.72910132
151MP0009764_decreased_sensitivity_to0.72023762
152MP0005551_abnormal_eye_electrophysiolog0.71472829
153MP0001286_abnormal_eye_development0.71443807
154MP0009643_abnormal_urine_homeostasis0.70729471
155MP0002282_abnormal_trachea_morphology0.70547202
156MP0005647_abnormal_sex_gland0.70144874
157MP0005423_abnormal_somatic_nervous0.69392154
158MP0000538_abnormal_urinary_bladder0.66258487
159MP0001270_distended_abdomen0.66172740
160* MP0002109_abnormal_limb_morphology0.65673889
161MP0001919_abnormal_reproductive_system0.64874107

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)7.11310064
2Chromsome breakage (HP:0040012)6.30055749
3Rhinitis (HP:0012384)6.08716685
4Chronic bronchitis (HP:0004469)4.77181838
5Bronchiectasis (HP:0002110)4.12728947
6Duplicated collecting system (HP:0000081)4.06152218
7Abnormality of the renal collecting system (HP:0004742)4.03599317
8Upper limb muscle weakness (HP:0003484)3.98154189
9Prostate neoplasm (HP:0100787)3.87737475
10Thyroid-stimulating hormone excess (HP:0002925)3.44852835
11Congenital stationary night blindness (HP:0007642)3.17611138
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.15118623
13Nasal polyposis (HP:0100582)3.08947223
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05347485
15Abnormality of DNA repair (HP:0003254)3.02817708
16Short nail (HP:0001799)3.02431810
17Febrile seizures (HP:0002373)2.99289544
18Abnormality of the preputium (HP:0100587)2.94108367
19Septo-optic dysplasia (HP:0100842)2.93563836
20Tubulointerstitial nephritis (HP:0001970)2.93551474
21Renal cortical cysts (HP:0000803)2.83698702
22Meckel diverticulum (HP:0002245)2.83334458
23Infertility (HP:0000789)2.76236120
24Clubbing of toes (HP:0100760)2.74258482
25Occipital encephalocele (HP:0002085)2.74066663
26Abnormality of the ileum (HP:0001549)2.68036920
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.67960089
28Congenital sensorineural hearing impairment (HP:0008527)2.63630797
29Aplasia cutis congenita (HP:0001057)2.63539254
30Nephroblastoma (Wilms tumor) (HP:0002667)2.63467888
31Ectopic kidney (HP:0000086)2.63458928
32Cystic liver disease (HP:0006706)2.61765376
33Hyperactive renin-angiotensin system (HP:0000841)2.58021705
34True hermaphroditism (HP:0010459)2.55895163
35Popliteal pterygium (HP:0009756)2.55107850
36Abnormality of the nasal septum (HP:0000419)2.49850325
37Embryonal renal neoplasm (HP:0011794)2.49164624
38Duplication of thumb phalanx (HP:0009942)2.43458880
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.40714318
40Absent/shortened dynein arms (HP:0200106)2.40714318
41Abnormality of chromosome stability (HP:0003220)2.40637024
42Tubular atrophy (HP:0000092)2.40185936
43Osteomalacia (HP:0002749)2.39067678
44White forelock (HP:0002211)2.34058971
45Abnormality of the nasal mucosa (HP:0000433)2.33186879
46Male infertility (HP:0003251)2.32011058
47Mesomelia (HP:0003027)2.26828857
48Abnormal ciliary motility (HP:0012262)2.24291680
49Patchy hypopigmentation of hair (HP:0011365)2.22778332
50Atelectasis (HP:0100750)2.20633542
51Cone-rod dystrophy (HP:0000548)2.20399951
52Pancreatic fibrosis (HP:0100732)2.18871850
53Abnormality of the prostate (HP:0008775)2.18816309
54Abnormality of the carotid arteries (HP:0005344)2.18540460
55Absent frontal sinuses (HP:0002688)2.18255932
56Lip pit (HP:0100267)2.15097488
57Medial flaring of the eyebrow (HP:0010747)2.14283850
58Optic nerve hypoplasia (HP:0000609)2.14269403
59Abnormality of incisor morphology (HP:0011063)2.14045359
60Bronchitis (HP:0012387)2.09178214
61Disproportionate short-trunk short stature (HP:0003521)2.07956584
62Decreased circulating renin level (HP:0003351)2.07206483
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.06847880
64Hypoplasia of the fovea (HP:0007750)2.06847880
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.06466613
66Retrobulbar optic neuritis (HP:0100654)2.06128950
67Optic neuritis (HP:0100653)2.06128950
68Decreased central vision (HP:0007663)2.05052428
69Abnormal respiratory motile cilium physiology (HP:0012261)2.02933071
70Abnormality of dentin (HP:0010299)2.01897752
71Congenital hepatic fibrosis (HP:0002612)2.01248211
72Congenital primary aphakia (HP:0007707)2.00760309
73Oligohydramnios (HP:0001562)1.99916214
74Cardiovascular calcification (HP:0011915)1.99570024
75Vascular calcification (HP:0004934)1.99041152
76Abnormality of the renal medulla (HP:0100957)1.98294121
77Preaxial hand polydactyly (HP:0001177)1.96678409
78Lower limb hyperreflexia (HP:0002395)1.95702793
79Stomach cancer (HP:0012126)1.93645699
80Metaphyseal dysplasia (HP:0100255)1.93640870
81Genital tract atresia (HP:0001827)1.92867056
82Morphological abnormality of the middle ear (HP:0008609)1.92703923
83Hypoplastic ischia (HP:0003175)1.90196345
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89702529
85Alveolar cell carcinoma (HP:0006519)1.89382253
86Loss of speech (HP:0002371)1.89376597
87Hypothermia (HP:0002045)1.89217222
88Median cleft lip (HP:0000161)1.89062642
89Abnormality of the renal cortex (HP:0011035)1.88701106
90Short thumb (HP:0009778)1.87944569
91Postaxial foot polydactyly (HP:0001830)1.87057119
92Chronic hepatic failure (HP:0100626)1.86974116
93Facial cleft (HP:0002006)1.86884579
94Broad distal phalanx of finger (HP:0009836)1.86757085
95Hand muscle atrophy (HP:0009130)1.86072403
96Duodenal stenosis (HP:0100867)1.86030958
97Small intestinal stenosis (HP:0012848)1.86030958
98Increased number of teeth (HP:0011069)1.85621271
99Abnormality of the parathyroid morphology (HP:0011766)1.85502813
100Chronic obstructive pulmonary disease (HP:0006510)1.83913516
101Obstructive lung disease (HP:0006536)1.83913516
102Nephronophthisis (HP:0000090)1.83153451
103Ovoid vertebral bodies (HP:0003300)1.81853736
104Gait imbalance (HP:0002141)1.81243042
105Distal lower limb muscle weakness (HP:0009053)1.81064621
106Aortic dissection (HP:0002647)1.80541637
107Renal dysplasia (HP:0000110)1.80070676
108Abnormal respiratory motile cilium morphology (HP:0005938)1.79830173
109Abnormal respiratory epithelium morphology (HP:0012253)1.79830173
110Aplasia/Hypoplasia of the macula (HP:0008059)1.79346529
111Renal agenesis (HP:0000104)1.79051833
112Anterior segment dysgenesis (HP:0007700)1.77549722
113Short thorax (HP:0010306)1.77188127
114Triphalangeal thumb (HP:0001199)1.77129576
115Spinal cord compression (HP:0002176)1.76902827
116Hypoplasia of the iris (HP:0007676)1.76680047
117Abnormal delayed hypersensitivity skin test (HP:0002963)1.75728670
118Flat acetabular roof (HP:0003180)1.75502825
119Hypergonadotropic hypogonadism (HP:0000815)1.75403745
120Pancreatic cysts (HP:0001737)1.74896992
121Bell-shaped thorax (HP:0001591)1.74749087
122Recurrent cutaneous fungal infections (HP:0011370)1.74282823
123Chronic mucocutaneous candidiasis (HP:0002728)1.74282823
124Hyperkalemia (HP:0002153)1.73966521
125Hyperaldosteronism (HP:0000859)1.73211434
126Nephrogenic diabetes insipidus (HP:0009806)1.72603951
127Entropion (HP:0000621)1.71454969
128Chronic sinusitis (HP:0011109)1.71366253
129Nasolacrimal duct obstruction (HP:0000579)1.70833025
130Chronic diarrhea (HP:0002028)1.70442882
131Embryonal neoplasm (HP:0002898)1.70189999
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69452836
133Mitral stenosis (HP:0001718)1.69351910
134Metaphyseal irregularity (HP:0003025)1.68755833
135Abnormality of the dental pulp (HP:0006479)1.68426188
136Anomalous pulmonary venous return (HP:0010772)1.68414270
137Xerostomia (HP:0000217)1.67867360
138Abnormality of the lacrimal duct (HP:0011481)1.67200911
139Microvesicular hepatic steatosis (HP:0001414)1.66908643
140Recurrent pneumonia (HP:0006532)1.66730430
141Vaginal atresia (HP:0000148)1.66710810
142Conical tooth (HP:0000698)1.66345599
143Submucous cleft hard palate (HP:0000176)1.66075549
144Abnormality of midbrain morphology (HP:0002418)1.65932116
145Molar tooth sign on MRI (HP:0002419)1.65932116
146Hypoplasia of the odontoid process (HP:0003311)1.65850046
147Meningitis (HP:0001287)1.64940071
148Cervical subluxation (HP:0003308)1.64608648
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64282804
150Keratoconus (HP:0000563)1.63615268
151Increased corneal curvature (HP:0100692)1.63615268
152Adrenal hypoplasia (HP:0000835)1.63159005
153Abnormality of the right ventricle (HP:0001707)1.63089374
154Absent septum pellucidum (HP:0001331)1.63055616
155Aplasia/Hypoplasia affecting the retina (HP:0008061)1.63036023
156Polydipsia (HP:0001959)1.62999865
157Abnormal drinking behavior (HP:0030082)1.62999865
158Attenuation of retinal blood vessels (HP:0007843)1.62663215
159Bone marrow hypocellularity (HP:0005528)1.62255582
160Abnormality of the distal phalanges of the toes (HP:0010182)1.62218490
161Poikiloderma (HP:0001029)1.60633591
162Abnormality of glycolipid metabolism (HP:0010969)1.60331556
163Abnormality of liposaccharide metabolism (HP:0010968)1.60331556
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.60331556
165Severe short stature (HP:0003510)1.59877787
166Supernumerary spleens (HP:0009799)1.58950294
167Abnormality of the fovea (HP:0000493)1.57323760
168Aplasia/Hypoplasia of the lens (HP:0008063)1.57242563
169Furrowed tongue (HP:0000221)1.56874696
170Postaxial hand polydactyly (HP:0001162)1.54166082
171Hypoplasia of the uterus (HP:0000013)1.53500034
172Short tibia (HP:0005736)1.53445546
173Short femoral neck (HP:0100864)1.52481952
174Bicornuate uterus (HP:0000813)1.51827568
175Enlarged penis (HP:0000040)1.50301155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.99456207
2EPHA23.24023309
3CASK3.23235213
4GRK13.18627886
5ZAK3.03315113
6INSRR2.92733646
7NEK92.92624408
8MST42.84885041
9TXK2.69492917
10TNIK2.69092121
11STK162.65087982
12EIF2AK22.53442952
13IRAK32.46596422
14MET2.34937089
15BLK2.33814560
16MAP3K142.31705618
17MKNK22.19848871
18NUAK12.07716938
19IRAK41.97980546
20NEK61.79372454
21TAOK31.79223176
22ADRBK21.76146882
23BMPR1B1.66875553
24ICK1.62446997
25SRPK11.61212577
26MAP3K21.61065655
27MAPKAPK31.57935577
28SIK31.49359194
29EPHB21.45934106
30PTK21.45373916
31YES11.43982182
32MAP2K71.43953021
33TEC1.43282267
34FLT31.42606913
35TRIM281.42473933
36TNK21.37417510
37NTRK31.34547460
38CDK81.32973885
39IRAK11.32682821
40SIK21.30170497
41SIK11.28109672
42CLK11.27768800
43IRAK21.26502859
44EPHA41.25377720
45MKNK11.25294534
46IKBKE1.24307296
47CDK31.24084223
48STK38L1.22667754
49DDR21.19681601
50MAPK151.18833062
51BMPR21.18668771
52MAPK131.15895632
53EPHA31.15665963
54LATS11.15491360
55MOS1.11409922
56EIF2AK31.10449387
57MUSK1.10103591
58MAP3K31.09352100
59LIMK11.09183125
60MAP3K71.08118446
61PTK2B1.05986102
62MELK1.05342981
63MARK21.00321870
64IKBKB0.99970707
65EEF2K0.98986604
66MAP3K130.98713096
67SGK20.98563573
68STK390.97303391
69BRD40.96424503
70PRPF4B0.95682972
71CDK120.95482445
72LRRK20.93392632
73ERBB20.93154146
74PLK40.91871135
75FER0.90988947
76NLK0.88658105
77GRK70.88221124
78AKT30.86716454
79MAPK110.85666315
80JAK30.85000410
81TESK10.81313530
82STK380.81270498
83ARAF0.81054629
84TRPM70.79184019
85CHUK0.77902655
86TLK10.77254938
87PRKCE0.75470498
88ADRBK10.73447032
89PKN10.73306094
90NTRK10.71727475
91JAK10.66161372
92MST1R0.65779571
93TAOK20.65138975
94BTK0.64448353
95TIE10.63708311
96PIK3CG0.62697963
97TGFBR10.62466730
98PIK3CA0.61874438
99CDK70.61103265
100ATR0.61084142
101LYN0.60560690
102EPHB10.60295122
103PRKCI0.59524793
104PAK20.58922334
105MTOR0.58045662
106MAP3K90.56523952
107CHEK20.56370011
108PRKD20.56309356
109DMPK0.56167399
110VRK10.55582162
111PRKAA20.55536706
112TBK10.55347260
113CSNK1G20.54813443
114LMTK20.53589953
115KIT0.53205269
116ERBB30.52392255
117MAP3K40.52270450
118RPS6KA50.51605824
119WNK30.50157823
120CSNK1G30.49765164
121IGF1R0.49199106
122WNK40.49113717
123PRKD30.48659123
124PRKAA10.47575887
125ERBB40.45438517
126PINK10.44879612
127ERN10.44660612
128STK40.43839473
129TRIB30.43717100
130MYLK0.43390251
131AKT20.43345754
132STK240.42628758
133TGFBR20.42574022
134STK30.42460646
135SGK10.42455225
136CAMK1D0.41808295
137SGK2230.40555444
138SGK4940.40555444
139PRKG10.39973706
140OBSCN0.38712612
141CDC42BPA0.38500823
142MAPK70.38264699
143CAMK10.38066661
144BCR0.36497733
145PIM20.36433729
146PRKCQ0.35367023
147MAPKAPK50.34571197
148CDK90.33896725
149HCK0.33720944
150CAMK1G0.33528540
151INSR0.33215917
152RPS6KA20.32531921
153AKT10.32420281
154LCK0.32162195
155MARK30.31817412
156CSNK1A1L0.31661856
157ATM0.31568772
158FGFR20.30985680
159HIPK20.30805170
160PRKCZ0.30744057
161CAMK40.30396396
162TTK0.30154362
163AURKA0.30091862

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.26017543
2Caffeine metabolism_Homo sapiens_hsa002322.77676568
3Sulfur relay system_Homo sapiens_hsa041222.66919558
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.57880231
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.42132097
6Histidine metabolism_Homo sapiens_hsa003402.34173183
7Phototransduction_Homo sapiens_hsa047442.16375868
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09407279
9Homologous recombination_Homo sapiens_hsa034402.04937473
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03786309
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99987613
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98768270
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94178867
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93526172
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.92187312
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87635970
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84643606
18Chemical carcinogenesis_Homo sapiens_hsa052041.81737940
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70689825
20Sphingolipid metabolism_Homo sapiens_hsa006001.67613604
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66306546
22Non-homologous end-joining_Homo sapiens_hsa034501.64809896
23Nicotine addiction_Homo sapiens_hsa050331.64674259
24Autoimmune thyroid disease_Homo sapiens_hsa053201.58532101
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.58475820
26Graft-versus-host disease_Homo sapiens_hsa053321.53963093
27Allograft rejection_Homo sapiens_hsa053301.53456643
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53305611
29Selenocompound metabolism_Homo sapiens_hsa004501.53171184
30Lysosome_Homo sapiens_hsa041421.52036472
31Asthma_Homo sapiens_hsa053101.50736938
32Hematopoietic cell lineage_Homo sapiens_hsa046401.50723604
33Basal transcription factors_Homo sapiens_hsa030221.46550332
34N-Glycan biosynthesis_Homo sapiens_hsa005101.43142328
35Tyrosine metabolism_Homo sapiens_hsa003501.42860532
36Measles_Homo sapiens_hsa051621.38402264
37Dorso-ventral axis formation_Homo sapiens_hsa043201.38081794
38Primary immunodeficiency_Homo sapiens_hsa053401.33308381
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.31562691
40Taste transduction_Homo sapiens_hsa047421.28663845
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27023659
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24116368
43Arachidonic acid metabolism_Homo sapiens_hsa005901.22188278
44Other glycan degradation_Homo sapiens_hsa005111.20163098
45Small cell lung cancer_Homo sapiens_hsa052221.19912542
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.18509791
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16809797
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16550804
49Glutathione metabolism_Homo sapiens_hsa004801.15696516
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15298558
51Hedgehog signaling pathway_Homo sapiens_hsa043401.13094769
52Malaria_Homo sapiens_hsa051441.11981812
53Butanoate metabolism_Homo sapiens_hsa006501.06349229
54Adherens junction_Homo sapiens_hsa045201.04699407
55Herpes simplex infection_Homo sapiens_hsa051681.03629832
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.03092404
57Rheumatoid arthritis_Homo sapiens_hsa053231.02837943
58Tryptophan metabolism_Homo sapiens_hsa003801.01547288
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00915576
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00906131
61Vitamin B6 metabolism_Homo sapiens_hsa007501.00041625
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.97959836
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92577159
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91077303
65TNF signaling pathway_Homo sapiens_hsa046680.90761771
66Lysine degradation_Homo sapiens_hsa003100.90620427
67Vitamin digestion and absorption_Homo sapiens_hsa049770.90130216
68Ether lipid metabolism_Homo sapiens_hsa005650.89631084
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89118068
70Hippo signaling pathway_Homo sapiens_hsa043900.88356125
71Morphine addiction_Homo sapiens_hsa050320.88246083
72Basal cell carcinoma_Homo sapiens_hsa052170.86453431
73Linoleic acid metabolism_Homo sapiens_hsa005910.86134739
74ABC transporters_Homo sapiens_hsa020100.85400253
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84206824
76Serotonergic synapse_Homo sapiens_hsa047260.83998424
77Influenza A_Homo sapiens_hsa051640.83938147
78Peroxisome_Homo sapiens_hsa041460.82642849
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80532972
80Ovarian steroidogenesis_Homo sapiens_hsa049130.79391877
81Leishmaniasis_Homo sapiens_hsa051400.78248021
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78042020
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76708733
84Folate biosynthesis_Homo sapiens_hsa007900.75924204
85p53 signaling pathway_Homo sapiens_hsa041150.75665873
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75647902
87African trypanosomiasis_Homo sapiens_hsa051430.74808281
88Focal adhesion_Homo sapiens_hsa045100.74767218
89Complement and coagulation cascades_Homo sapiens_hsa046100.73408144
90Glycerolipid metabolism_Homo sapiens_hsa005610.73335022
91Chemokine signaling pathway_Homo sapiens_hsa040620.72434011
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70709889
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70534127
94Proteoglycans in cancer_Homo sapiens_hsa052050.69344203
95Arginine and proline metabolism_Homo sapiens_hsa003300.69032129
96Fatty acid degradation_Homo sapiens_hsa000710.66660708
97Calcium signaling pathway_Homo sapiens_hsa040200.66033208
98Osteoclast differentiation_Homo sapiens_hsa043800.65843590
99Melanoma_Homo sapiens_hsa052180.65114831
100Staphylococcus aureus infection_Homo sapiens_hsa051500.64353130
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63104254
102Prostate cancer_Homo sapiens_hsa052150.61320758
103Tight junction_Homo sapiens_hsa045300.60327581
104Notch signaling pathway_Homo sapiens_hsa043300.60160990
105Insulin resistance_Homo sapiens_hsa049310.60070029
106ECM-receptor interaction_Homo sapiens_hsa045120.59591879
107Base excision repair_Homo sapiens_hsa034100.58521199
108Type I diabetes mellitus_Homo sapiens_hsa049400.58496731
109Retinol metabolism_Homo sapiens_hsa008300.56169073
110Purine metabolism_Homo sapiens_hsa002300.55980578
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55785134
112Wnt signaling pathway_Homo sapiens_hsa043100.55344576
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55263478
114Pyrimidine metabolism_Homo sapiens_hsa002400.55155797
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53811911
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53060792
117Thyroid hormone synthesis_Homo sapiens_hsa049180.50749660
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50568324
119Phagosome_Homo sapiens_hsa041450.50552271
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50530165
121Nucleotide excision repair_Homo sapiens_hsa034200.49642097
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49389960
123Axon guidance_Homo sapiens_hsa043600.49288536
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48336076
125Dilated cardiomyopathy_Homo sapiens_hsa054140.47695480
126RNA degradation_Homo sapiens_hsa030180.47125502
127RNA polymerase_Homo sapiens_hsa030200.47108733
128Non-small cell lung cancer_Homo sapiens_hsa052230.46762340
129MicroRNAs in cancer_Homo sapiens_hsa052060.46563378
130Ras signaling pathway_Homo sapiens_hsa040140.46116798
131Phenylalanine metabolism_Homo sapiens_hsa003600.45865632
132cAMP signaling pathway_Homo sapiens_hsa040240.45461379
133beta-Alanine metabolism_Homo sapiens_hsa004100.44982970
134Mismatch repair_Homo sapiens_hsa034300.42654904
135Circadian rhythm_Homo sapiens_hsa047100.42325631
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41339196
137Hepatitis B_Homo sapiens_hsa051610.40989357
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.40738810
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40586260
140Glutamatergic synapse_Homo sapiens_hsa047240.40469631
141Hepatitis C_Homo sapiens_hsa051600.40205485
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39973333
143Prolactin signaling pathway_Homo sapiens_hsa049170.38899842
144Protein digestion and absorption_Homo sapiens_hsa049740.38536677
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38048835
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38027597
147Pathways in cancer_Homo sapiens_hsa052000.37959749
148Inositol phosphate metabolism_Homo sapiens_hsa005620.37437270
149PPAR signaling pathway_Homo sapiens_hsa033200.35741279
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35131148
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.34445739
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32191121
153Choline metabolism in cancer_Homo sapiens_hsa052310.31744159
154Metabolic pathways_Homo sapiens_hsa011000.30448924
155Starch and sucrose metabolism_Homo sapiens_hsa005000.29280497
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28425700
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25871748
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25069648

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