

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 7.90075262 |
| 2 | actin-myosin filament sliding (GO:0033275) | 7.12680686 |
| 3 | muscle filament sliding (GO:0030049) | 7.12680686 |
| 4 | cardiac myofibril assembly (GO:0055003) | 6.76063132 |
| 5 | myofibril assembly (GO:0030239) | 6.73931359 |
| 6 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 6.59498391 |
| 7 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 6.53677273 |
| 8 | regulation of skeletal muscle contraction (GO:0014819) | 6.48644971 |
| 9 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.25470480 |
| 10 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.22414080 |
| 11 | plasma membrane repair (GO:0001778) | 6.15471398 |
| 12 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 5.90446534 |
| 13 | actin-mediated cell contraction (GO:0070252) | 5.85281495 |
| 14 | cardiac muscle contraction (GO:0060048) | 5.80420045 |
| 15 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.77126915 |
| 16 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.72283682 |
| 17 | regulation of actin filament-based movement (GO:1903115) | 5.46177311 |
| 18 | tricarboxylic acid cycle (GO:0006099) | 5.44803418 |
| 19 | regulation of relaxation of muscle (GO:1901077) | 5.41788322 |
| 20 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.31268084 |
| 21 | striated muscle contraction (GO:0006941) | 5.21012471 |
| 22 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.15883544 |
| 23 | regulation of cell communication by electrical coupling (GO:0010649) | 5.08335003 |
| 24 | actomyosin structure organization (GO:0031032) | 5.06128012 |
| 25 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.88338563 |
| 26 | cardiac muscle cell development (GO:0055013) | 4.87719450 |
| 27 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.71567900 |
| 28 | regulation of membrane repolarization (GO:0060306) | 4.70116478 |
| 29 | adult heart development (GO:0007512) | 4.68878395 |
| 30 | creatine metabolic process (GO:0006600) | 4.65667860 |
| 31 | skeletal muscle contraction (GO:0003009) | 4.63414005 |
| 32 | cardiac cell development (GO:0055006) | 4.58701838 |
| 33 | carnitine shuttle (GO:0006853) | 4.58670035 |
| 34 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.52614592 |
| 35 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.49285834 |
| 36 | regulation of striated muscle contraction (GO:0006942) | 4.48337993 |
| 37 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.46253982 |
| 38 | actin filament-based movement (GO:0030048) | 4.36319928 |
| 39 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.28683361 |
| 40 | detection of calcium ion (GO:0005513) | 4.24183274 |
| 41 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.23781850 |
| 42 | cardiac muscle hypertrophy (GO:0003300) | 4.21524743 |
| 43 | heart trabecula formation (GO:0060347) | 4.19536286 |
| 44 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.17972987 |
| 45 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.14286810 |
| 46 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.14245301 |
| 47 | muscle tissue morphogenesis (GO:0060415) | 4.12375508 |
| 48 | striated muscle hypertrophy (GO:0014897) | 4.08124974 |
| 49 | negative regulation of protein localization to cell surface (GO:2000009) | 4.05026817 |
| 50 | cell communication involved in cardiac conduction (GO:0086065) | 4.03531308 |
| 51 | regulation of coenzyme metabolic process (GO:0051196) | 4.02501679 |
| 52 | regulation of cofactor metabolic process (GO:0051193) | 4.02501679 |
| 53 | heart contraction (GO:0060047) | 3.94127420 |
| 54 | heart process (GO:0003015) | 3.94127420 |
| 55 | regulation of sarcomere organization (GO:0060297) | 3.93763289 |
| 56 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.90202665 |
| 57 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.83539697 |
| 58 | fatty acid transmembrane transport (GO:1902001) | 3.82168991 |
| 59 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.79880006 |
| 60 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.79880006 |
| 61 | respiratory electron transport chain (GO:0022904) | 3.77032268 |
| 62 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.75816380 |
| 63 | cell communication by electrical coupling (GO:0010644) | 3.75656149 |
| 64 | muscle contraction (GO:0006936) | 3.73413036 |
| 65 | skeletal muscle adaptation (GO:0043501) | 3.73144525 |
| 66 | relaxation of cardiac muscle (GO:0055119) | 3.67191492 |
| 67 | electron transport chain (GO:0022900) | 3.65156395 |
| 68 | regulation of the force of heart contraction (GO:0002026) | 3.63609577 |
| 69 | response to inactivity (GO:0014854) | 3.63456527 |
| 70 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.63297817 |
| 71 | cardiac muscle cell action potential (GO:0086001) | 3.61495880 |
| 72 | ATP synthesis coupled proton transport (GO:0015986) | 3.61481181 |
| 73 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.61481181 |
| 74 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.61247923 |
| 75 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.61247923 |
| 76 | regulation of cardiac muscle contraction (GO:0055117) | 3.60621682 |
| 77 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.58241750 |
| 78 | glycogen catabolic process (GO:0005980) | 3.55737122 |
| 79 | positive regulation of cation channel activity (GO:2001259) | 3.55269806 |
| 80 | muscle hypertrophy (GO:0014896) | 3.54073157 |
| 81 | negative regulation of potassium ion transport (GO:0043267) | 3.49147352 |
| 82 | carnitine transmembrane transport (GO:1902603) | 3.48949787 |
| 83 | NADH metabolic process (GO:0006734) | 3.45801261 |
| 84 | regulation of heart rate (GO:0002027) | 3.44926346 |
| 85 | muscle system process (GO:0003012) | 3.42903431 |
| 86 | response to epinephrine (GO:0071871) | 3.42510040 |
| 87 | relaxation of muscle (GO:0090075) | 3.37589035 |
| 88 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.31621357 |
| 89 | glucan catabolic process (GO:0009251) | 3.31069282 |
| 90 | regulation of ATPase activity (GO:0043462) | 3.29464510 |
| 91 | regulation of ATP catabolic process (GO:1903289) | 3.29464510 |
| 92 | striated muscle adaptation (GO:0014888) | 3.25741921 |
| 93 | cellular response to epinephrine stimulus (GO:0071872) | 3.25287032 |
| 94 | regulation of sequestering of triglyceride (GO:0010889) | 3.25276464 |
| 95 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.25103530 |
| 96 | oxygen transport (GO:0015671) | 3.22916543 |
| 97 | regulation of cation channel activity (GO:2001257) | 3.22565998 |
| 98 | regulation of heart contraction (GO:0008016) | 3.21812060 |
| 99 | 2-oxoglutarate metabolic process (GO:0006103) | 3.21652117 |
| 100 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.21640544 |
| 101 | regulation of sulfur metabolic process (GO:0042762) | 3.21401103 |
| 102 | positive regulation of sodium ion transport (GO:0010765) | 3.19673450 |
| 103 | amino-acid betaine transport (GO:0015838) | 3.19431614 |
| 104 | carnitine transport (GO:0015879) | 3.19431614 |
| 105 | response to muscle activity (GO:0014850) | 3.19026704 |
| 106 | muscle adaptation (GO:0043500) | 3.18753097 |
| 107 | striated muscle cell development (GO:0055002) | 3.17442359 |
| 108 | cardiac muscle adaptation (GO:0014887) | 3.17249237 |
| 109 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.17249237 |
| 110 | muscle hypertrophy in response to stress (GO:0003299) | 3.17249237 |
| 111 | potassium ion import (GO:0010107) | 3.16780522 |
| 112 | muscle fiber development (GO:0048747) | 3.16233460 |
| 113 | skeletal muscle fiber development (GO:0048741) | 3.14871352 |
| 114 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.13696262 |
| 115 | positive regulation of heart rate (GO:0010460) | 3.13674450 |
| 116 | regulation of muscle contraction (GO:0006937) | 3.11568495 |
| 117 | cardiac conduction (GO:0061337) | 3.11368812 |
| 118 | sodium ion export (GO:0071436) | 3.09638485 |
| 119 | regulation of sodium ion transmembrane transport (GO:1902305) | 3.08005461 |
| 120 | regulation of muscle system process (GO:0090257) | 3.07709068 |
| 121 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.07584201 |
| 122 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.04786020 |
| 123 | neuronal action potential propagation (GO:0019227) | 3.00417101 |
| 124 | cellular potassium ion homeostasis (GO:0030007) | 2.95910211 |
| 125 | activation of protein kinase A activity (GO:0034199) | 2.94550041 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.86408500 |
| 2 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.43206141 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.34624016 |
| 4 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 3.34065500 |
| 5 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.81367857 |
| 6 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.81367857 |
| 7 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.45067811 |
| 8 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.36218054 |
| 9 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.28451017 |
| 10 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.05507528 |
| 11 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.05358394 |
| 12 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.04798670 |
| 13 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.02583059 |
| 14 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.95095881 |
| 15 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.92563129 |
| 16 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.92240416 |
| 17 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.82624902 |
| 18 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.80934527 |
| 19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.74673447 |
| 20 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.74642405 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.73733949 |
| 22 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.71876870 |
| 23 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.71327961 |
| 24 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.64964914 |
| 25 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.64964914 |
| 26 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.62736782 |
| 27 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.52292684 |
| 28 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.49704634 |
| 29 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.47218698 |
| 30 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.43192938 |
| 31 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.36257904 |
| 32 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.35446113 |
| 33 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.33817760 |
| 34 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.33343062 |
| 35 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.30936440 |
| 36 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.28649479 |
| 37 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.27936650 |
| 38 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.27810746 |
| 39 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26109325 |
| 40 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.25139299 |
| 41 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.23590050 |
| 42 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.23396161 |
| 43 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.22836616 |
| 44 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.22663336 |
| 45 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20481412 |
| 46 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.20408737 |
| 47 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.19422278 |
| 48 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.18394114 |
| 49 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.17609007 |
| 50 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.17200341 |
| 51 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.17005317 |
| 52 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.16229872 |
| 53 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.16224802 |
| 54 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.12721642 |
| 55 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.10867245 |
| 56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09595318 |
| 57 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.08985398 |
| 58 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.08552787 |
| 59 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.07368676 |
| 60 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.04442192 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.02759544 |
| 62 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.01183997 |
| 63 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.98970689 |
| 64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98111058 |
| 65 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.98020633 |
| 66 | GATA1_22025678_ChIP-Seq_K562_Human | 0.97629471 |
| 67 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.97593768 |
| 68 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.97151303 |
| 69 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.93566696 |
| 70 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.92095267 |
| 71 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.91935970 |
| 72 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.91364555 |
| 73 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.90530899 |
| 74 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.88529571 |
| 75 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.88212909 |
| 76 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.88074009 |
| 77 | * FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.87417135 |
| 78 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.87389961 |
| 79 | KDM2B_26808549_Chip-Seq_K562_Human | 0.87362655 |
| 80 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.87153181 |
| 81 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.86973758 |
| 82 | AR_19668381_ChIP-Seq_PC3_Human | 0.86563024 |
| 83 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.85903313 |
| 84 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.85760519 |
| 85 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.85695224 |
| 86 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.85223535 |
| 87 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.84464836 |
| 88 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.84269403 |
| 89 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.84257664 |
| 90 | * OCT4_20526341_ChIP-Seq_ESCs_Human | 0.83967895 |
| 91 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.82472207 |
| 92 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82268507 |
| 93 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.82147603 |
| 94 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.82136797 |
| 95 | GATA1_19941826_ChIP-Seq_K562_Human | 0.82108453 |
| 96 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.82030797 |
| 97 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.80380498 |
| 98 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.80153990 |
| 99 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.80009667 |
| 100 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.79895215 |
| 101 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.79745791 |
| 102 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.79682057 |
| 103 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.79603081 |
| 104 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.79106699 |
| 105 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.78789323 |
| 106 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.77847378 |
| 107 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.77685358 |
| 108 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.77424809 |
| 109 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.76949957 |
| 110 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.76761632 |
| 111 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.76679086 |
| 112 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.76351884 |
| 113 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.76079946 |
| 114 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.75981937 |
| 115 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.75242602 |
| 116 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.74834190 |
| 117 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.74793937 |
| 118 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.74409170 |
| 119 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.74105851 |
| 120 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.74105851 |
| 121 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.74045837 |
| 122 | P68_20966046_ChIP-Seq_HELA_Human | 0.74000078 |
| 123 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.72610028 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.53492688 |
| 2 | MP0003646_muscle_fatigue | 6.05316929 |
| 3 | MP0000751_myopathy | 5.46809194 |
| 4 | MP0004084_abnormal_cardiac_muscle | 4.60145427 |
| 5 | MP0000749_muscle_degeneration | 4.42886985 |
| 6 | MP0004036_abnormal_muscle_relaxation | 4.22351318 |
| 7 | MP0004215_abnormal_myocardial_fiber | 4.10243738 |
| 8 | MP0004145_abnormal_muscle_electrophysio | 3.60195899 |
| 9 | MP0005330_cardiomyopathy | 3.29594828 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.04422275 |
| 11 | MP0002106_abnormal_muscle_physiology | 2.82383603 |
| 12 | MP0005620_abnormal_muscle_contractility | 2.77011740 |
| 13 | MP0002972_abnormal_cardiac_muscle | 2.74547699 |
| 14 | MP0000750_abnormal_muscle_regeneration | 2.70303967 |
| 15 | MP0003137_abnormal_impulse_conducting | 2.67568821 |
| 16 | MP0004130_abnormal_muscle_cell | 2.59914647 |
| 17 | MP0000747_muscle_weakness | 2.52782566 |
| 18 | MP0002269_muscular_atrophy | 2.50041294 |
| 19 | MP0005369_muscle_phenotype | 2.35252470 |
| 20 | MP0000759_abnormal_skeletal_muscle | 2.32151874 |
| 21 | MP0008775_abnormal_heart_ventricle | 2.24501557 |
| 22 | MP0004484_altered_response_of | 2.18377650 |
| 23 | MP0005385_cardiovascular_system_phenoty | 2.17504987 |
| 24 | MP0001544_abnormal_cardiovascular_syste | 2.17504987 |
| 25 | MP0010630_abnormal_cardiac_muscle | 2.10837212 |
| 26 | MP0006138_congestive_heart_failure | 1.98229663 |
| 27 | MP0004233_abnormal_muscle_weight | 1.93905442 |
| 28 | MP0004085_abnormal_heartbeat | 1.83473843 |
| 29 | MP0005451_abnormal_body_composition | 1.80759720 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.68498807 |
| 31 | MP0002332_abnormal_exercise_endurance | 1.62745711 |
| 32 | MP0003221_abnormal_cardiomyocyte_apopto | 1.51048524 |
| 33 | MP0003828_pulmonary_edema | 1.49555599 |
| 34 | MP0003950_abnormal_plasma_membrane | 1.47114935 |
| 35 | MP0005423_abnormal_somatic_nervous | 1.43789050 |
| 36 | MP0002127_abnormal_cardiovascular_syste | 1.38479011 |
| 37 | MP0005666_abnormal_adipose_tissue | 1.32700042 |
| 38 | MP0004510_myositis | 1.31609108 |
| 39 | MP0002108_abnormal_muscle_morphology | 1.15195124 |
| 40 | MP0003880_abnormal_central_pattern | 1.13424755 |
| 41 | MP0004185_abnormal_adipocyte_glucose | 1.07876188 |
| 42 | MP0004043_abnormal_pH_regulation | 1.07530591 |
| 43 | MP0004270_analgesia | 1.01708287 |
| 44 | MP0002234_abnormal_pharynx_morphology | 1.00056624 |
| 45 | MP0005670_abnormal_white_adipose | 1.00031284 |
| 46 | MP0003879_abnormal_hair_cell | 0.97060313 |
| 47 | MP0005375_adipose_tissue_phenotype | 0.96428283 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 0.95122167 |
| 49 | MP0000343_altered_response_to | 0.94655535 |
| 50 | MP0005165_increased_susceptibility_to | 0.93062917 |
| 51 | MP0002734_abnormal_mechanical_nocicepti | 0.91728811 |
| 52 | MP0004147_increased_porphyrin_level | 0.90903055 |
| 53 | MP0002063_abnormal_learning/memory/cond | 0.89838527 |
| 54 | MP0002909_abnormal_adrenal_gland | 0.89613745 |
| 55 | MP0000266_abnormal_heart_morphology | 0.86535131 |
| 56 | MP0003279_aneurysm | 0.84242383 |
| 57 | MP0008569_lethality_at_weaning | 0.82978737 |
| 58 | MP0000013_abnormal_adipose_tissue | 0.82565020 |
| 59 | MP0005623_abnormal_meninges_morphology | 0.82320143 |
| 60 | MP0005266_abnormal_metabolism | 0.80937709 |
| 61 | MP0000733_abnormal_muscle_development | 0.77667081 |
| 62 | MP0000230_abnormal_systemic_arterial | 0.76135447 |
| 63 | MP0005167_abnormal_blood-brain_barrier | 0.75521366 |
| 64 | MP0003329_amyloid_beta_deposits | 0.74612089 |
| 65 | MP0001984_abnormal_olfaction | 0.72527445 |
| 66 | MP0003045_fibrosis | 0.71613307 |
| 67 | MP0003567_abnormal_fetal_cardiomyocyte | 0.69301115 |
| 68 | MP0002638_abnormal_pupillary_reflex | 0.68196370 |
| 69 | MP0002572_abnormal_emotion/affect_behav | 0.68149796 |
| 70 | MP0002971_abnormal_brown_adipose | 0.66760450 |
| 71 | MP0000003_abnormal_adipose_tissue | 0.63934297 |
| 72 | MP0001501_abnormal_sleep_pattern | 0.62917440 |
| 73 | MP0003806_abnormal_nucleotide_metabolis | 0.61956405 |
| 74 | MP0001502_abnormal_circadian_rhythm | 0.60184315 |
| 75 | MP0009780_abnormal_chondrocyte_physiolo | 0.59667226 |
| 76 | MP0002128_abnormal_blood_circulation | 0.56683311 |
| 77 | MP0001299_abnormal_eye_distance/ | 0.56053702 |
| 78 | MP0002272_abnormal_nervous_system | 0.55517221 |
| 79 | MP0001485_abnormal_pinna_reflex | 0.55291441 |
| 80 | MP0004859_abnormal_synaptic_plasticity | 0.53897183 |
| 81 | MP0008874_decreased_physiological_sensi | 0.53018234 |
| 82 | MP0001970_abnormal_pain_threshold | 0.51407190 |
| 83 | MP0004924_abnormal_behavior | 0.51339766 |
| 84 | MP0005386_behavior/neurological_phenoty | 0.51339766 |
| 85 | MP0002822_catalepsy | 0.51241777 |
| 86 | MP0009046_muscle_twitch | 0.50425127 |
| 87 | MP0002078_abnormal_glucose_homeostasis | 0.50124885 |
| 88 | MP0005646_abnormal_pituitary_gland | 0.47958481 |
| 89 | MP0000920_abnormal_myelination | 0.47823162 |
| 90 | MP0001661_extended_life_span | 0.46483387 |
| 91 | MP0004858_abnormal_nervous_system | 0.46427076 |
| 92 | MP0010368_abnormal_lymphatic_system | 0.44792156 |
| 93 | MP0001440_abnormal_grooming_behavior | 0.44740952 |
| 94 | MP0004142_abnormal_muscle_tone | 0.44534262 |
| 95 | MP0005535_abnormal_body_temperature | 0.44506374 |
| 96 | MP0001529_abnormal_vocalization | 0.43748500 |
| 97 | MP0003705_abnormal_hypodermis_morpholog | 0.42565750 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.41165123 |
| 99 | MP0003633_abnormal_nervous_system | 0.41104968 |
| 100 | MP0003635_abnormal_synaptic_transmissio | 0.40511395 |
| 101 | MP0003631_nervous_system_phenotype | 0.40140528 |
| 102 | MP0005187_abnormal_penis_morphology | 0.38941253 |
| 103 | MP0003195_calcinosis | 0.38820100 |
| 104 | MP0009840_abnormal_foam_cell | 0.38335786 |
| 105 | MP0002733_abnormal_thermal_nociception | 0.38299000 |
| 106 | MP0005377_hearing/vestibular/ear_phenot | 0.36502652 |
| 107 | MP0003878_abnormal_ear_physiology | 0.36502652 |
| 108 | MP0008961_abnormal_basal_metabolism | 0.36362688 |
| 109 | MP0003690_abnormal_glial_cell | 0.36162968 |
| 110 | MP0002067_abnormal_sensory_capabilities | 0.36142534 |
| 111 | MP0005166_decreased_susceptibility_to | 0.35899916 |
| 112 | MP0003634_abnormal_glial_cell | 0.35260389 |
| 113 | MP0002064_seizures | 0.34555613 |
| 114 | MP0002735_abnormal_chemical_nociception | 0.34258785 |
| 115 | MP0001486_abnormal_startle_reflex | 0.34170441 |
| 116 | MP0002229_neurodegeneration | 0.32924685 |
| 117 | MP0003656_abnormal_erythrocyte_physiolo | 0.32817623 |
| 118 | MP0003948_abnormal_gas_homeostasis | 0.32763541 |
| 119 | MP0002066_abnormal_motor_capabilities/c | 0.32756674 |
| 120 | MP0000767_abnormal_smooth_muscle | 0.31716930 |
| 121 | MP0009745_abnormal_behavioral_response | 0.31295904 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 7.36522548 |
| 2 | Sudden death (HP:0001699) | 6.83553049 |
| 3 | Calf muscle hypertrophy (HP:0008981) | 6.73372518 |
| 4 | Exercise-induced muscle cramps (HP:0003710) | 6.72194564 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.65332215 |
| 6 | Muscle fiber splitting (HP:0003555) | 5.97318523 |
| 7 | Ventricular tachycardia (HP:0004756) | 5.58562515 |
| 8 | Abnormality of the calf musculature (HP:0001430) | 5.28863548 |
| 9 | Hyporeflexia of lower limbs (HP:0002600) | 5.27565838 |
| 10 | Myoglobinuria (HP:0002913) | 5.17016726 |
| 11 | Atrial fibrillation (HP:0005110) | 4.84575235 |
| 12 | Subaortic stenosis (HP:0001682) | 4.70970388 |
| 13 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.70970388 |
| 14 | Difficulty running (HP:0009046) | 4.68051869 |
| 15 | EMG: myopathic abnormalities (HP:0003458) | 4.53930775 |
| 16 | Primary atrial arrhythmia (HP:0001692) | 4.50867049 |
| 17 | Muscle fiber inclusion bodies (HP:0100299) | 4.34079987 |
| 18 | Supraventricular tachycardia (HP:0004755) | 4.33212569 |
| 19 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.32232380 |
| 20 | Lipoatrophy (HP:0100578) | 4.24935229 |
| 21 | Supraventricular arrhythmia (HP:0005115) | 4.23265889 |
| 22 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.22477114 |
| 23 | Bundle branch block (HP:0011710) | 4.11261896 |
| 24 | Increased connective tissue (HP:0009025) | 4.06432976 |
| 25 | Myotonia (HP:0002486) | 3.99734624 |
| 26 | Asymmetric septal hypertrophy (HP:0001670) | 3.86937304 |
| 27 | Prolonged QT interval (HP:0001657) | 3.81018435 |
| 28 | Syncope (HP:0001279) | 3.80125382 |
| 29 | Rhabdomyolysis (HP:0003201) | 3.75957077 |
| 30 | Dilated cardiomyopathy (HP:0001644) | 3.70452118 |
| 31 | Right ventricular cardiomyopathy (HP:0011663) | 3.63589917 |
| 32 | Palpitations (HP:0001962) | 3.63154562 |
| 33 | Type 1 muscle fiber predominance (HP:0003803) | 3.58990605 |
| 34 | Nemaline bodies (HP:0003798) | 3.57642021 |
| 35 | Muscle stiffness (HP:0003552) | 3.51272799 |
| 36 | Heart block (HP:0012722) | 3.36887497 |
| 37 | Ventricular arrhythmia (HP:0004308) | 3.29214190 |
| 38 | Ventricular fibrillation (HP:0001663) | 3.22579001 |
| 39 | Difficulty climbing stairs (HP:0003551) | 3.17065908 |
| 40 | Abnormal atrioventricular conduction (HP:0005150) | 3.15727687 |
| 41 | Atrioventricular block (HP:0001678) | 3.05108760 |
| 42 | Increased variability in muscle fiber diameter (HP:0003557) | 2.98631855 |
| 43 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.85676743 |
| 44 | Acute necrotizing encephalopathy (HP:0006965) | 2.81298318 |
| 45 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.78930021 |
| 46 | Abnormal EKG (HP:0003115) | 2.74669058 |
| 47 | Left ventricular hypertrophy (HP:0001712) | 2.72791849 |
| 48 | Neck muscle weakness (HP:0000467) | 2.71776055 |
| 49 | Distal arthrogryposis (HP:0005684) | 2.67174704 |
| 50 | Distal lower limb muscle weakness (HP:0009053) | 2.66858741 |
| 51 | Areflexia of lower limbs (HP:0002522) | 2.66547737 |
| 52 | Ketoacidosis (HP:0001993) | 2.62276066 |
| 53 | Hepatic necrosis (HP:0002605) | 2.55155946 |
| 54 | Round ear (HP:0100830) | 2.51814348 |
| 55 | Myopathic facies (HP:0002058) | 2.48580559 |
| 56 | Acute encephalopathy (HP:0006846) | 2.46829966 |
| 57 | Hepatocellular necrosis (HP:0001404) | 2.39493290 |
| 58 | Limb-girdle muscle atrophy (HP:0003797) | 2.37603570 |
| 59 | Hypoplastic ischia (HP:0003175) | 2.37426397 |
| 60 | Progressive macrocephaly (HP:0004481) | 2.35487222 |
| 61 | Bulbar palsy (HP:0001283) | 2.30639212 |
| 62 | Pheochromocytoma (HP:0002666) | 2.29202807 |
| 63 | Gowers sign (HP:0003391) | 2.28977451 |
| 64 | Mitochondrial inheritance (HP:0001427) | 2.25720904 |
| 65 | Abnormality of the foot musculature (HP:0001436) | 2.22121447 |
| 66 | Foot dorsiflexor weakness (HP:0009027) | 2.22000280 |
| 67 | Rimmed vacuoles (HP:0003805) | 2.21117022 |
| 68 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.20458733 |
| 69 | EMG: neuropathic changes (HP:0003445) | 2.19609655 |
| 70 | Calcaneovalgus deformity (HP:0001848) | 2.18112628 |
| 71 | Muscular dystrophy (HP:0003560) | 2.14506557 |
| 72 | Palmoplantar keratoderma (HP:0000982) | 2.13208791 |
| 73 | Abnormality of the ischium (HP:0003174) | 2.11149684 |
| 74 | Testicular atrophy (HP:0000029) | 2.11141905 |
| 75 | Increased muscle lipid content (HP:0009058) | 2.10316837 |
| 76 | Large for gestational age (HP:0001520) | 2.09615696 |
| 77 | Exercise intolerance (HP:0003546) | 2.08547737 |
| 78 | Absent phalangeal crease (HP:0006109) | 2.07864184 |
| 79 | Distal lower limb amyotrophy (HP:0008944) | 2.07496318 |
| 80 | Myokymia (HP:0002411) | 2.07180777 |
| 81 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.06010956 |
| 82 | Increased CSF lactate (HP:0002490) | 2.03600423 |
| 83 | Neuroendocrine neoplasm (HP:0100634) | 2.01948928 |
| 84 | Weak cry (HP:0001612) | 2.01041639 |
| 85 | Cerebral edema (HP:0002181) | 2.00975950 |
| 86 | Generalized muscle weakness (HP:0003324) | 1.96671833 |
| 87 | Steppage gait (HP:0003376) | 1.92419272 |
| 88 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.90930365 |
| 89 | Scapular winging (HP:0003691) | 1.90782754 |
| 90 | Sudden cardiac death (HP:0001645) | 1.90699168 |
| 91 | Ketosis (HP:0001946) | 1.90420247 |
| 92 | Hypoglycemic coma (HP:0001325) | 1.89382571 |
| 93 | Dicarboxylic aciduria (HP:0003215) | 1.88853002 |
| 94 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.88853002 |
| 95 | Progressive muscle weakness (HP:0003323) | 1.88637676 |
| 96 | Deformed tarsal bones (HP:0008119) | 1.88438246 |
| 97 | Respiratory failure (HP:0002878) | 1.86252233 |
| 98 | Lactic acidosis (HP:0003128) | 1.86234551 |
| 99 | Facial diplegia (HP:0001349) | 1.85989449 |
| 100 | Increased intramyocellular lipid droplets (HP:0012240) | 1.85265763 |
| 101 | Proximal amyotrophy (HP:0007126) | 1.83780463 |
| 102 | Dysmetric saccades (HP:0000641) | 1.82697514 |
| 103 | Fetal akinesia sequence (HP:0001989) | 1.81361342 |
| 104 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.81171256 |
| 105 | Malignant hyperthermia (HP:0002047) | 1.80580736 |
| 106 | Ulnar deviation of the wrist (HP:0003049) | 1.78076789 |
| 107 | Hyperkalemia (HP:0002153) | 1.74479197 |
| 108 | Focal motor seizures (HP:0011153) | 1.73855015 |
| 109 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.73523764 |
| 110 | Conjunctival hamartoma (HP:0100780) | 1.73321891 |
| 111 | Waddling gait (HP:0002515) | 1.73251990 |
| 112 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.72576902 |
| 113 | Athetosis (HP:0002305) | 1.72377063 |
| 114 | Lower limb amyotrophy (HP:0007210) | 1.72227880 |
| 115 | Ragged-red muscle fibers (HP:0003200) | 1.71771712 |
| 116 | Frequent falls (HP:0002359) | 1.70975891 |
| 117 | Ankle clonus (HP:0011448) | 1.70961685 |
| 118 | Limb-girdle muscle weakness (HP:0003325) | 1.69127233 |
| 119 | Abnormal finger flexion creases (HP:0006143) | 1.64914586 |
| 120 | Hip contracture (HP:0003273) | 1.57759452 |
| 121 | Spinal rigidity (HP:0003306) | 1.55324027 |
| 122 | Abnormality of the neuromuscular junction (HP:0003398) | 1.53090051 |
| 123 | Fatigable weakness (HP:0003473) | 1.53090051 |
| 124 | Rapidly progressive (HP:0003678) | 1.49321236 |
| 125 | Congestive heart failure (HP:0001635) | 1.48664406 |
| 126 | Slow progression (HP:0003677) | 1.48413030 |
| 127 | Hypoplastic heart (HP:0001961) | 1.46568661 |
| 128 | Hypoplastic left heart (HP:0004383) | 1.46561856 |
| 129 | Abnormality of the tricuspid valve (HP:0001702) | 1.45598654 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 5.84213106 |
| 2 | PHKG2 | 5.44393777 |
| 3 | PHKG1 | 5.44393777 |
| 4 | OBSCN | 4.55645724 |
| 5 | LMTK2 | 3.82550441 |
| 6 | PDK3 | 2.99021106 |
| 7 | PDK4 | 2.99021106 |
| 8 | DMPK | 2.65134558 |
| 9 | MUSK | 2.63631805 |
| 10 | MYLK | 2.53844375 |
| 11 | PINK1 | 2.45138771 |
| 12 | MARK1 | 2.30272548 |
| 13 | TRIB3 | 2.21684507 |
| 14 | PIK3CA | 2.02353127 |
| 15 | BCKDK | 1.95701206 |
| 16 | NEK1 | 1.84601495 |
| 17 | PDK2 | 1.84230530 |
| 18 | PKN2 | 1.54600513 |
| 19 | NME1 | 1.35551637 |
| 20 | DAPK2 | 1.31318993 |
| 21 | WNK4 | 1.31045370 |
| 22 | PAK3 | 1.29089390 |
| 23 | TIE1 | 1.26486777 |
| 24 | CAMK2D | 1.24251352 |
| 25 | MAP3K7 | 1.23249204 |
| 26 | LIMK1 | 1.21331126 |
| 27 | MAPK12 | 1.19242605 |
| 28 | PRKD1 | 1.15394836 |
| 29 | STK24 | 1.12165832 |
| 30 | WNK1 | 1.12019126 |
| 31 | STK39 | 1.05093575 |
| 32 | GRK7 | 1.02882238 |
| 33 | PKN1 | 1.01780591 |
| 34 | PIK3CG | 0.90960923 |
| 35 | ROCK1 | 0.90026452 |
| 36 | MAP2K3 | 0.89774247 |
| 37 | EPHB1 | 0.88526566 |
| 38 | MAPKAPK3 | 0.86132506 |
| 39 | PRKAA1 | 0.85297584 |
| 40 | CDC42BPA | 0.84788101 |
| 41 | PRKD3 | 0.83077990 |
| 42 | ROCK2 | 0.80770645 |
| 43 | ILK | 0.80357696 |
| 44 | RIPK1 | 0.79825405 |
| 45 | PRKAA2 | 0.78192509 |
| 46 | MAP2K4 | 0.77009530 |
| 47 | INSRR | 0.75889837 |
| 48 | TRPM7 | 0.75022687 |
| 49 | CAMK2G | 0.72931075 |
| 50 | CAMK2A | 0.70222752 |
| 51 | PRPF4B | 0.69635210 |
| 52 | STK38 | 0.67275915 |
| 53 | EEF2K | 0.66826383 |
| 54 | NTRK2 | 0.64308223 |
| 55 | MAPK4 | 0.62884424 |
| 56 | DDR2 | 0.62811364 |
| 57 | CDK5 | 0.58452271 |
| 58 | ARAF | 0.58390679 |
| 59 | DAPK3 | 0.58370570 |
| 60 | SIK1 | 0.58089238 |
| 61 | MAP3K4 | 0.57912973 |
| 62 | PDPK1 | 0.55380174 |
| 63 | MAP3K5 | 0.54897581 |
| 64 | MAP3K9 | 0.54842250 |
| 65 | MAP2K1 | 0.53283763 |
| 66 | ICK | 0.53026420 |
| 67 | CAMK4 | 0.52587503 |
| 68 | PRKACB | 0.52426583 |
| 69 | PRKCH | 0.52106837 |
| 70 | MAP3K6 | 0.51961722 |
| 71 | PRKCE | 0.51232491 |
| 72 | PDGFRA | 0.50489809 |
| 73 | PAK6 | 0.50425299 |
| 74 | MAPK10 | 0.49508980 |
| 75 | PTK2B | 0.48601392 |
| 76 | NTRK3 | 0.47204274 |
| 77 | PRKACA | 0.46252010 |
| 78 | MAP3K13 | 0.46054567 |
| 79 | MOS | 0.45628420 |
| 80 | CCNB1 | 0.42833071 |
| 81 | EPHA4 | 0.42180764 |
| 82 | GRK5 | 0.41836396 |
| 83 | PDK1 | 0.40353712 |
| 84 | STK38L | 0.39586164 |
| 85 | CAMK1 | 0.39133737 |
| 86 | SGK494 | 0.37563118 |
| 87 | SGK223 | 0.37563118 |
| 88 | UHMK1 | 0.35953768 |
| 89 | MAPK13 | 0.35243692 |
| 90 | SGK3 | 0.34463410 |
| 91 | PRKACG | 0.34342702 |
| 92 | SGK1 | 0.32845638 |
| 93 | RPS6KL1 | 0.32414466 |
| 94 | RPS6KC1 | 0.32414466 |
| 95 | MAP2K6 | 0.32312005 |
| 96 | DYRK1B | 0.31705940 |
| 97 | CAMKK1 | 0.31597040 |
| 98 | STK4 | 0.30683613 |
| 99 | PRKG1 | 0.30456856 |
| 100 | AKT2 | 0.29631350 |
| 101 | KSR2 | 0.29500544 |
| 102 | MAP3K1 | 0.29324072 |
| 103 | CAMK2B | 0.28510046 |
| 104 | LATS2 | 0.28102921 |
| 105 | MAPK15 | 0.27613114 |
| 106 | RPS6KA3 | 0.26653154 |
| 107 | NEK9 | 0.25995994 |
| 108 | MAP3K3 | 0.25816364 |
| 109 | FER | 0.25359316 |
| 110 | RPS6KA6 | 0.25318557 |
| 111 | ZAK | 0.25067399 |
| 112 | EPHA3 | 0.24353574 |
| 113 | NTRK1 | 0.24295791 |
| 114 | RET | 0.23176542 |
| 115 | RPS6KA1 | 0.23086910 |
| 116 | MINK1 | 0.22791346 |
| 117 | MAP3K11 | 0.22327256 |
| 118 | SGK2 | 0.20622377 |
| 119 | TAOK1 | 0.20227617 |
| 120 | PRKG2 | 0.20195204 |
| 121 | MARK2 | 0.18430552 |
| 122 | MAPK7 | 0.18341720 |
| 123 | WNK3 | 0.17867998 |
| 124 | STK11 | 0.17160616 |
| 125 | CAMK1G | 0.17062357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.98094114 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.13970498 |
| 3 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.60439573 |
| 4 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.39213300 |
| 5 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.31566263 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.08849506 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.05256738 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.97873581 |
| 9 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.70565056 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.42799604 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.41640138 |
| 12 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.37220297 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.08408050 |
| 14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.03962109 |
| 15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.01890597 |
| 16 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.00380378 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.88184352 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.86111142 |
| 19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.74922547 |
| 20 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.47397844 |
| 21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.34242239 |
| 22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.32364006 |
| 23 | Viral myocarditis_Homo sapiens_hsa05416 | 1.28865259 |
| 24 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.19833951 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.16879937 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.14260813 |
| 27 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.13514213 |
| 28 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.13297742 |
| 29 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.08791643 |
| 30 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.08218458 |
| 31 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.04438302 |
| 32 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04261584 |
| 33 | Insulin resistance_Homo sapiens_hsa04931 | 1.03270443 |
| 34 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.99863969 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.99057848 |
| 36 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.98389808 |
| 37 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.98219352 |
| 38 | Insulin secretion_Homo sapiens_hsa04911 | 0.93537279 |
| 39 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.93374532 |
| 40 | Nicotine addiction_Homo sapiens_hsa05033 | 0.86608233 |
| 41 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.82116605 |
| 42 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.81933364 |
| 43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79937843 |
| 44 | Circadian rhythm_Homo sapiens_hsa04710 | 0.79334049 |
| 45 | Circadian entrainment_Homo sapiens_hsa04713 | 0.75881479 |
| 46 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.75755798 |
| 47 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.72987652 |
| 48 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.72650140 |
| 49 | Renin secretion_Homo sapiens_hsa04924 | 0.72298181 |
| 50 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.68520844 |
| 51 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.67985112 |
| 52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.67090256 |
| 53 | Cocaine addiction_Homo sapiens_hsa05030 | 0.66090784 |
| 54 | Histidine metabolism_Homo sapiens_hsa00340 | 0.65783507 |
| 55 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.64232733 |
| 56 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.64138158 |
| 57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.63707815 |
| 58 | Tight junction_Homo sapiens_hsa04530 | 0.63337209 |
| 59 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.63051670 |
| 60 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.62002363 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.60365270 |
| 62 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.58161766 |
| 63 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.56297509 |
| 64 | Focal adhesion_Homo sapiens_hsa04510 | 0.55014559 |
| 65 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.53505336 |
| 66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.52120823 |
| 67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49856859 |
| 68 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.49843491 |
| 69 | GABAergic synapse_Homo sapiens_hsa04727 | 0.49652471 |
| 70 | Long-term depression_Homo sapiens_hsa04730 | 0.49469285 |
| 71 | Peroxisome_Homo sapiens_hsa04146 | 0.48298700 |
| 72 | Taste transduction_Homo sapiens_hsa04742 | 0.47669231 |
| 73 | Salivary secretion_Homo sapiens_hsa04970 | 0.47492644 |
| 74 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.46061755 |
| 75 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.45794350 |
| 76 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.45161189 |
| 77 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.44642527 |
| 78 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44563364 |
| 79 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.44513381 |
| 80 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.43052975 |
| 81 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.42814895 |
| 82 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.42179947 |
| 83 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.42098607 |
| 84 | Prion diseases_Homo sapiens_hsa05020 | 0.41916225 |
| 85 | Lysine degradation_Homo sapiens_hsa00310 | 0.38969374 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.38654826 |
| 87 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.38557959 |
| 88 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.38440582 |
| 89 | Gap junction_Homo sapiens_hsa04540 | 0.38100197 |
| 90 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.38089413 |
| 91 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.38072297 |
| 92 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.36898336 |
| 93 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.35998126 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.34826390 |
| 95 | Glioma_Homo sapiens_hsa05214 | 0.34660036 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.32970731 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32548961 |
| 98 | Long-term potentiation_Homo sapiens_hsa04720 | 0.32263882 |
| 99 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.30738445 |
| 100 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.30732379 |
| 101 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.26976717 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.25689540 |
| 103 | Metabolic pathways_Homo sapiens_hsa01100 | 0.24330675 |
| 104 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.24194284 |
| 105 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.23690994 |
| 106 | Bile secretion_Homo sapiens_hsa04976 | 0.23681519 |
| 107 | Melanogenesis_Homo sapiens_hsa04916 | 0.22745125 |
| 108 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22249760 |
| 109 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.21558811 |
| 110 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.21426417 |
| 111 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.20912794 |
| 112 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.20471138 |
| 113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.20001475 |
| 114 | Amoebiasis_Homo sapiens_hsa05146 | 0.19366649 |
| 115 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.19134450 |
| 116 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.18935322 |
| 117 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.16654859 |
| 118 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.15633503 |

