HHIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.68100292
2axon ensheathment in central nervous system (GO:0032291)9.68100292
3endothelium development (GO:0003158)9.37960469
4wound healing, spreading of epidermal cells (GO:0035313)7.26804494
5lateral sprouting from an epithelium (GO:0060601)6.68387296
6retina vasculature morphogenesis in camera-type eye (GO:0061299)6.68119102
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.47680663
8ensheathment of neurons (GO:0007272)6.37670195
9axon ensheathment (GO:0008366)6.37670195
10myelination (GO:0042552)6.37589234
11artery development (GO:0060840)6.33179929
12positive regulation of endothelial cell differentiation (GO:0045603)6.22312756
13fatty acid elongation (GO:0030497)6.18128236
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.34866288
15negative regulation of neurotransmitter secretion (GO:0046929)5.32764447
16long-chain fatty acid biosynthetic process (GO:0042759)5.06923212
17regulation of endothelial cell differentiation (GO:0045601)5.02685250
18negative regulation of nitric-oxide synthase activity (GO:0051001)4.93601924
19wound healing, spreading of cells (GO:0044319)4.89652956
20regulation of glomerular filtration (GO:0003093)4.88280244
21substrate-dependent cell migration (GO:0006929)4.81218608
22limb bud formation (GO:0060174)4.74663503
23positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)4.72256464
24branching involved in labyrinthine layer morphogenesis (GO:0060670)4.67372694
25endothelial tube morphogenesis (GO:0061154)4.66108441
26morphogenesis of an endothelium (GO:0003159)4.66108441
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.55911351
28peripheral nervous system axon ensheathment (GO:0032292)4.55249801
29myelination in peripheral nervous system (GO:0022011)4.55249801
30astrocyte development (GO:0014002)4.53895975
31negative regulation of neurotransmitter transport (GO:0051589)4.52882167
32positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.52632962
33mesenchymal-epithelial cell signaling (GO:0060638)4.47201638
34sprouting angiogenesis (GO:0002040)4.40925330
35negative regulation of blood vessel endothelial cell migration (GO:0043537)4.35252917
36cholesterol biosynthetic process (GO:0006695)4.34312690
37negative regulation of focal adhesion assembly (GO:0051895)4.33553017
38negative regulation of cell junction assembly (GO:1901889)4.33553017
39negative regulation of adherens junction organization (GO:1903392)4.33553017
40myelin maintenance (GO:0043217)4.32016732
41organ growth (GO:0035265)4.29602060
42cell adhesion mediated by integrin (GO:0033627)4.28787033
43regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.24541297
44asymmetric protein localization (GO:0008105)4.16803069
45oligodendrocyte differentiation (GO:0048709)4.10094583
46negative regulation of JUN kinase activity (GO:0043508)4.09375376
47apical protein localization (GO:0045176)4.08606480
48chondrocyte proliferation (GO:0035988)4.07985972
49otic vesicle formation (GO:0030916)4.04770955
50negative regulation of chondrocyte differentiation (GO:0032331)4.02122486
51embryonic heart tube development (GO:0035050)3.99897918
52venous blood vessel morphogenesis (GO:0048845)3.97906445
53regulation of collateral sprouting (GO:0048670)3.96531295
54eye photoreceptor cell differentiation (GO:0001754)3.95477229
55photoreceptor cell differentiation (GO:0046530)3.95477229
56endothelial cell differentiation (GO:0045446)3.93989740
57anatomical structure maturation (GO:0071695)3.93435169
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.92072447
59creatine metabolic process (GO:0006600)3.89366353
60positive regulation of interleukin-8 secretion (GO:2000484)3.87912088
61positive regulation of endothelial cell migration (GO:0010595)3.83553923
62negative regulation of endothelial cell proliferation (GO:0001937)3.80304059
63craniofacial suture morphogenesis (GO:0097094)3.79878407
64positive regulation of blood vessel endothelial cell migration (GO:0043536)3.79328760
65neuronal ion channel clustering (GO:0045161)3.78707972
66patterning of blood vessels (GO:0001569)3.73152077
67bone trabecula formation (GO:0060346)3.72895112
68mesenchymal cell proliferation (GO:0010463)3.72629595
69lymph vessel development (GO:0001945)3.72328426
70sterol biosynthetic process (GO:0016126)3.71821631
71regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.71033621
72endothelial cell proliferation (GO:0001935)3.69484859
73negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.69118964
74glycerophospholipid catabolic process (GO:0046475)3.67768779
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.65744444
76negative regulation of DNA biosynthetic process (GO:2000279)3.62640396
77presynaptic membrane organization (GO:0097090)3.62172726
78positive regulation of chondrocyte differentiation (GO:0032332)3.61956243
79positive regulation of fibroblast migration (GO:0010763)3.61855547
80regulation of blood vessel endothelial cell migration (GO:0043535)3.60443562
81regulation of chondrocyte differentiation (GO:0032330)3.59873948
82regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.58956736
83positive regulation of urine volume (GO:0035810)3.58765499
84branching involved in salivary gland morphogenesis (GO:0060445)3.57936070
85regulation of sarcomere organization (GO:0060297)3.57654096
86negative regulation of protein localization to cell surface (GO:2000009)3.57168707
87adhesion of symbiont to host cell (GO:0044650)3.56414500
88virion attachment to host cell (GO:0019062)3.56414500
89positive regulation of cartilage development (GO:0061036)3.55410879
90blood vessel remodeling (GO:0001974)3.53422257
91establishment of mitochondrion localization (GO:0051654)3.52784823
92cellular response to cholesterol (GO:0071397)3.52540108
93angiogenesis involved in wound healing (GO:0060055)3.52159224
94branching involved in prostate gland morphogenesis (GO:0060442)3.51877840
95regulation of chemokine-mediated signaling pathway (GO:0070099)3.45862321
96negative regulation of endothelial cell migration (GO:0010596)3.44618727
97presynaptic membrane assembly (GO:0097105)3.43090406
98cell proliferation involved in kidney development (GO:0072111)3.42669786
99regulation of establishment or maintenance of cell polarity (GO:0032878)3.40336547
100regulation of establishment of cell polarity (GO:2000114)3.35157815
101regulation of endothelial cell migration (GO:0010594)3.34570777
102cranial suture morphogenesis (GO:0060363)3.34092069
103positive regulation of odontogenesis (GO:0042482)3.33538563
104radial glial cell differentiation (GO:0060019)3.32601616
105branch elongation of an epithelium (GO:0060602)3.31999762
106renal system process involved in regulation of blood volume (GO:0001977)3.30855366
107positive regulation of collagen biosynthetic process (GO:0032967)3.30086837
108regulation of osteoblast proliferation (GO:0033688)3.29758034
109somite development (GO:0061053)3.28174137
110response to methylmercury (GO:0051597)3.28024239
111regulation of pigment cell differentiation (GO:0050932)3.27196303
112positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.24356327
113negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.24170402
114SMAD protein complex assembly (GO:0007183)3.23394185
115isoprenoid biosynthetic process (GO:0008299)3.23327551
116neuron projection extension involved in neuron projection guidance (GO:1902284)3.22572391
117axon extension involved in axon guidance (GO:0048846)3.22572391
118positive regulation of oligodendrocyte differentiation (GO:0048714)3.20941909
119regulation of non-canonical Wnt signaling pathway (GO:2000050)3.20500827
120positive regulation of epithelial cell migration (GO:0010634)3.20152717
121import into cell (GO:0098657)3.19323303
122response to lipoprotein particle (GO:0055094)3.18878361
123response to magnesium ion (GO:0032026)3.18214084
124negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.17974834
125cell migration involved in heart development (GO:0060973)3.16822040
126pharyngeal system development (GO:0060037)3.15892795
127L-amino acid import (GO:0043092)3.15706029
128peptidyl-tyrosine autophosphorylation (GO:0038083)3.15047752
129negative regulation of cell-substrate adhesion (GO:0010812)3.14690548
130positive regulation of muscle hypertrophy (GO:0014742)3.13797921
131positive regulation of cardiac muscle hypertrophy (GO:0010613)3.13797921
132glomerular filtration (GO:0003094)3.13282632
133positive regulation of BMP signaling pathway (GO:0030513)3.12257435
134nephron epithelium development (GO:0072009)3.11901445
135angiogenesis (GO:0001525)3.11627301
136vascular endothelial growth factor signaling pathway (GO:0038084)3.09696394
137semaphorin-plexin signaling pathway (GO:0071526)3.09571544
138positive regulation of collagen metabolic process (GO:0010714)3.08521381
139digestive tract morphogenesis (GO:0048546)3.08085957
140negative regulation of cell-matrix adhesion (GO:0001953)3.07882660
141regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.06517763
142substrate adhesion-dependent cell spreading (GO:0034446)3.06165979
143drinking behavior (GO:0042756)3.04296164
144regulation of cartilage development (GO:0061035)3.02208121
145ganglion development (GO:0061548)3.01936878
146inositol phosphate-mediated signaling (GO:0048016)3.00652764
147endochondral ossification (GO:0001958)3.00043789
148replacement ossification (GO:0036075)3.00043789
149substantia nigra development (GO:0021762)2.98876223
150heparin biosynthetic process (GO:0030210)2.97241155
151heparin metabolic process (GO:0030202)2.97241155
152regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.96733200
153regulation of plasminogen activation (GO:0010755)2.96394579
154negative regulation of monooxygenase activity (GO:0032769)2.94404655
155long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.94308314
156cell proliferation involved in metanephros development (GO:0072203)2.94213219
157negative regulation of fibrinolysis (GO:0051918)2.94133498
158renal filtration (GO:0097205)2.93259692
159regulation of systemic arterial blood pressure by hormone (GO:0001990)2.92215733
160regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.92215733
161endocrine process (GO:0050886)2.92215733
162negative regulation of platelet activation (GO:0010544)2.90453390
163membrane tubulation (GO:0097320)2.89907428
164negative chemotaxis (GO:0050919)2.89850270
165response to redox state (GO:0051775)2.88798519
166negative regulation of axonogenesis (GO:0050771)2.85816067
167negative regulation of osteoblast proliferation (GO:0033689)2.84916019
168cerebral cortex radially oriented cell migration (GO:0021799)2.83096283
169artery smooth muscle contraction (GO:0014824)2.82019710
170response to follicle-stimulating hormone (GO:0032354)2.76848894
171keratinocyte proliferation (GO:0043616)2.76009511
172amyloid precursor protein metabolic process (GO:0042982)2.75616095
173cellular response to sterol (GO:0036315)2.75483920
174protein palmitoylation (GO:0018345)2.73922775
175interleukin-6-mediated signaling pathway (GO:0070102)2.72890429
176long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72055868
177enteric nervous system development (GO:0048484)2.72042539
178mesodermal cell differentiation (GO:0048333)2.69571344
179axis elongation (GO:0003401)2.67658669
180magnesium ion transport (GO:0015693)2.65692573
181negative regulation of axon extension (GO:0030517)2.63871913
182tonic smooth muscle contraction (GO:0014820)2.63653545
183cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.62831362
184adhesion of symbiont to host (GO:0044406)2.60322107
185Leydig cell differentiation (GO:0033327)2.57767912
186nerve growth factor signaling pathway (GO:0038180)2.55375550
187regulation of lipoprotein metabolic process (GO:0050746)2.55173334
188axon development (GO:0061564)2.55012938
189vascular smooth muscle contraction (GO:0014829)2.54829481
190fatty-acyl-CoA biosynthetic process (GO:0046949)2.51899637
191glial cell development (GO:0021782)2.50544949
192peripheral nervous system development (GO:0007422)2.50203301
193neuron remodeling (GO:0016322)2.48937882
194mesenchymal cell differentiation (GO:0048762)2.47471593
195regulation of developmental pigmentation (GO:0048070)2.47005547
196blood vessel maturation (GO:0001955)10.9763622
197lymphangiogenesis (GO:0001946)10.2213923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GATA2_21666600_ChIP-Seq_HMVEC_Human5.17464952
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.10727988
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.60280428
4GBX2_23144817_ChIP-Seq_PC3_Human3.26630145
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46234692
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45972656
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.40251987
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34961640
9* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.29517519
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27413178
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24255031
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.16710479
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11824162
14CJUN_26792858_Chip-Seq_BT549_Human2.11440676
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06021473
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04382216
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02878645
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02878645
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02325949
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00592985
21AR_21572438_ChIP-Seq_LNCaP_Human1.99307155
22TAF15_26573619_Chip-Seq_HEK293_Human1.97443091
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96907918
24EZH2_22144423_ChIP-Seq_EOC_Human1.93919534
25BRD4_25478319_ChIP-Seq_HGPS_Human1.89900451
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88875648
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85454934
28VDR_22108803_ChIP-Seq_LS180_Human1.84503843
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84290864
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78684496
31ER_23166858_ChIP-Seq_MCF-7_Human1.78431466
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.76460939
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73207456
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.72055996
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71763862
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71067365
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.69857134
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66628420
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65310609
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63295214
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.59884496
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57133328
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56293382
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.56126740
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55128596
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53658607
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49992471
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.49163428
49FUS_26573619_Chip-Seq_HEK293_Human1.48307089
50DROSHA_22980978_ChIP-Seq_HELA_Human1.47046952
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46845762
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.46770299
53* P300_19829295_ChIP-Seq_ESCs_Human1.42612187
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42055847
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39137169
56STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38462107
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38452470
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36958842
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36325155
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36325155
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36108419
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.34585496
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33853322
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33853322
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33853322
66AHR_22903824_ChIP-Seq_MCF-7_Human1.32981224
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.32713133
68SMAD4_21799915_ChIP-Seq_A2780_Human1.31829100
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29470677
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29410803
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28825828
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.27889436
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.27884165
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27562373
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27256290
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26697627
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25890812
78* STAT3_23295773_ChIP-Seq_U87_Human1.23533362
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23015281
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22961507
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22914506
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.21726037
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.21109368
84* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20685694
85* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18064553
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18063194
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17302433
88BCAT_22108803_ChIP-Seq_LS180_Human1.16946564
89TP53_18474530_ChIP-ChIP_U2OS_Human1.15502953
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14169110
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13661875
92TP53_16413492_ChIP-PET_HCT116_Human1.12433040
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10720951
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10210458
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.10206677
96* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08815440
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08310311
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08093818
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.07117432
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.06386734
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.06386734
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06318969
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04507258
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03859972
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03859972
106* TCF4_23295773_ChIP-Seq_U87_Human1.03666086
107TP63_23658742_ChIP-Seq_EP156T_Human1.01853918
108TP53_23651856_ChIP-Seq_MEFs_Mouse1.01502777
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01422217
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01393309
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01157488
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99895158
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99895158
114* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99728929
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99717770
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99698583
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99375662
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.99127866
119* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98873421
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.98674825
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98554911
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98487041
123KDM2B_26808549_Chip-Seq_REH_Human0.98403371
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98164359
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97820399
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97638122
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97510431
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97505929
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97264805
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96424240
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96090758
132RXR_22108803_ChIP-Seq_LS180_Human0.95632096
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.95529425
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95331108
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.94974360
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.94685124
137* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94518186
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93635723
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.92831567
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.91424096
141P300_18555785_Chip-Seq_ESCs_Mouse0.90760189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system8.06145311
2MP0005167_abnormal_blood-brain_barrier5.20853112
3MP0001879_abnormal_lymphatic_vessel5.06288983
4MP0000920_abnormal_myelination4.77977154
5MP0003279_aneurysm3.45991083
6MP0000566_synostosis3.12412908
7MP0001299_abnormal_eye_distance/3.02904496
8MP0002938_white_spotting3.02748490
9MP0003136_yellow_coat_color2.82747925
10MP0003950_abnormal_plasma_membrane2.81445126
11MP0004134_abnormal_chest_morphology2.72450373
12MP0003828_pulmonary_edema2.71253201
13MP0001661_extended_life_span2.64440602
14MP0000462_abnormal_digestive_system2.63119605
15MP0003690_abnormal_glial_cell2.56058137
16MP0004885_abnormal_endolymph2.55768196
17MP0000465_gastrointestinal_hemorrhage2.54459800
18MP0005503_abnormal_tendon_morphology2.49651107
19MP0000767_abnormal_smooth_muscle2.46398102
20MP0002138_abnormal_hepatobiliary_system2.45943619
21MP0005409_darkened_coat_color2.34327938
22MP0009780_abnormal_chondrocyte_physiolo2.30386394
23MP0003566_abnormal_cell_adhesion2.27607047
24MP0003880_abnormal_central_pattern2.22135891
25MP0005171_absent_coat_pigmentation2.21274758
26MP0001346_abnormal_lacrimal_gland2.20227550
27MP0004272_abnormal_basement_membrane2.17299586
28MP0000383_abnormal_hair_follicle2.17204615
29MP0009250_abnormal_appendicular_skeleto2.16413743
30MP0004270_analgesia2.14229181
31MP0005595_abnormal_vascular_smooth2.13473854
32MP0000537_abnormal_urethra_morphology2.06779709
33MP0010678_abnormal_skin_adnexa2.05547845
34MP0004233_abnormal_muscle_weight1.98450555
35MP0005187_abnormal_penis_morphology1.96570631
36MP0003937_abnormal_limbs/digits/tail_de1.94470023
37MP0000647_abnormal_sebaceous_gland1.91100257
38MP0000778_abnormal_nervous_system1.90551201
39MP0003634_abnormal_glial_cell1.86011630
40MP0002877_abnormal_melanocyte_morpholog1.78666013
41MP0003938_abnormal_ear_development1.78132006
42MP0003091_abnormal_cell_migration1.77920398
43MP0001486_abnormal_startle_reflex1.77363936
44MP0006054_spinal_hemorrhage1.77056923
45MP0004742_abnormal_vestibular_system1.76335363
46MP0002272_abnormal_nervous_system1.75509983
47MP0008438_abnormal_cutaneous_collagen1.75441928
48MP0004381_abnormal_hair_follicle1.72857237
49MP0003868_abnormal_feces_composition1.72283389
50MP0000579_abnormal_nail_morphology1.69986289
51MP0001485_abnormal_pinna_reflex1.68694658
52MP0003705_abnormal_hypodermis_morpholog1.66826957
53MP0004145_abnormal_muscle_electrophysio1.65223250
54MP0003632_abnormal_nervous_system1.63763254
55MP0003329_amyloid_beta_deposits1.60919313
56MP0002108_abnormal_muscle_morphology1.60608184
57MP0001529_abnormal_vocalization1.57182818
58MP0003941_abnormal_skin_development1.54608135
59MP0006138_congestive_heart_failure1.53836549
60MP0000762_abnormal_tongue_morphology1.50554381
61MP0002295_abnormal_pulmonary_circulatio1.49560410
62MP0001177_atelectasis1.48371230
63MP0002127_abnormal_cardiovascular_syste1.47766154
64MP0001905_abnormal_dopamine_level1.43522656
65MP0002925_abnormal_cardiovascular_devel1.42953428
66MP0001614_abnormal_blood_vessel1.42661793
67MP0000428_abnormal_craniofacial_morphol1.42209375
68MP0001915_intracranial_hemorrhage1.39676643
69MP0000049_abnormal_middle_ear1.37834134
70MP0009697_abnormal_copulation1.37831369
71MP0010352_gastrointestinal_tract_polyps1.37070139
72MP0004142_abnormal_muscle_tone1.36512347
73MP0005257_abnormal_intraocular_pressure1.35674403
74MP0002064_seizures1.33329460
75MP0002933_joint_inflammation1.29252774
76MP0000249_abnormal_blood_vessel1.29094992
77MP0005248_abnormal_Harderian_gland1.27934141
78MP0005075_abnormal_melanosome_morpholog1.25655744
79MP0002102_abnormal_ear_morphology1.23869752
80MP0002128_abnormal_blood_circulation1.23126589
81MP0000427_abnormal_hair_cycle1.22732980
82MP0003724_increased_susceptibility_to1.21911485
83MP0009046_muscle_twitch1.21201207
84MP0002168_other_aberrant_phenotype1.20949548
85MP0000955_abnormal_spinal_cord1.19633148
86MP0003385_abnormal_body_wall1.16615175
87MP0003300_gastrointestinal_ulcer1.14852997
88MP0001958_emphysema1.14001626
89MP0000569_abnormal_digit_pigmentation1.12259560
90MP0004484_altered_response_of1.11703815
91MP0002282_abnormal_trachea_morphology1.09478179
92MP0000639_abnormal_adrenal_gland1.07621020
93MP0001340_abnormal_eyelid_morphology1.07326837
94MP0002098_abnormal_vibrissa_morphology1.07052794
95* MP0003935_abnormal_craniofacial_develop1.06008320
96MP0003303_peritoneal_inflammation1.05758820
97* MP0002882_abnormal_neuron_morphology1.05723483
98MP0005084_abnormal_gallbladder_morpholo1.05504323
99MP0000013_abnormal_adipose_tissue1.05397793
100MP0004085_abnormal_heartbeat1.02248696
101MP0002229_neurodegeneration0.98301840
102MP0005451_abnormal_body_composition0.97983315
103MP0004782_abnormal_surfactant_physiolog0.97879137
104MP0003755_abnormal_palate_morphology0.96341772
105MP0005197_abnormal_uvea_morphology0.96279664
106MP0000751_myopathy0.96116258
107MP0008004_abnormal_stomach_pH0.95898509
108MP0000343_altered_response_to0.95690565
109MP0002332_abnormal_exercise_endurance0.95295081
110MP0005410_abnormal_fertilization0.94587493
111MP0003942_abnormal_urinary_system0.94276971
112MP0010030_abnormal_orbit_morphology0.93962431
113MP0001851_eye_inflammation0.93646718
114MP0003631_nervous_system_phenotype0.91902580
115MP0003635_abnormal_synaptic_transmissio0.90134576
116MP0002133_abnormal_respiratory_system0.89816316
117MP0005388_respiratory_system_phenotype0.89816316
118MP0000372_irregular_coat_pigmentation0.87656387
119MP0005508_abnormal_skeleton_morphology0.86152980
120MP0001348_abnormal_lacrimal_gland0.85457390
121MP0002177_abnormal_outer_ear0.85293124
122MP0005023_abnormal_wound_healing0.85001426
123MP0000747_muscle_weakness0.84872317
124MP0002116_abnormal_craniofacial_bone0.83744963
125MP0002752_abnormal_somatic_nervous0.83250964
126MP0003045_fibrosis0.83003073
127MP0001784_abnormal_fluid_regulation0.82739275
128MP0009745_abnormal_behavioral_response0.82013907
129MP0005623_abnormal_meninges_morphology0.79843240
130MP0004859_abnormal_synaptic_plasticity0.79449304
131MP0002160_abnormal_reproductive_system0.79168084
132MP0000516_abnormal_urinary_system0.78917579
133MP0005367_renal/urinary_system_phenotyp0.78917579
134MP0004084_abnormal_cardiac_muscle0.77450242
135MP0002896_abnormal_bone_mineralization0.76791149
136MP0002572_abnormal_emotion/affect_behav0.76610385
137MP0005551_abnormal_eye_electrophysiolog0.75882247
138MP0000534_abnormal_ureter_morphology0.75253395
139MP0003633_abnormal_nervous_system0.75227389
140MP0002734_abnormal_mechanical_nocicepti0.74888096
141MP0005386_behavior/neurological_phenoty0.74364457
142MP0004924_abnormal_behavior0.74364457
143MP0003984_embryonic_growth_retardation0.73176472
144MP0002932_abnormal_joint_morphology0.72943578
145MP0005195_abnormal_posterior_eye0.72718461
146MP0001963_abnormal_hearing_physiology0.71541649
147MP0000266_abnormal_heart_morphology0.71164894
148MP0001243_abnormal_dermal_layer0.70395708
149MP0000733_abnormal_muscle_development0.69855783
150MP0002066_abnormal_motor_capabilities/c0.69013607
151MP0000631_abnormal_neuroendocrine_gland0.66781204
152MP0002088_abnormal_embryonic_growth/wei0.66706290
153MP0005360_urolithiasis0.66177345
154MP0002109_abnormal_limb_morphology0.65809522
155* MP0001293_anophthalmia0.64887154
156MP0005395_other_phenotype0.64884243
157MP0005408_hypopigmentation0.64672546
158MP0003191_abnormal_cellular_cholesterol0.64137110
159MP0000026_abnormal_inner_ear0.63959616
160MP0000613_abnormal_salivary_gland0.63736228
161* MP0002092_abnormal_eye_morphology0.63498829
162MP0006276_abnormal_autonomic_nervous0.62894382
163MP0001849_ear_inflammation0.62866212
164MP0005165_increased_susceptibility_to0.62059178
165MP0004215_abnormal_myocardial_fiber0.61989566
166MP0004883_abnormal_blood_vessel0.59480245
167MP0003075_altered_response_to0.58406672
168MP0005166_decreased_susceptibility_to0.56827034
169MP0001544_abnormal_cardiovascular_syste0.55118795
170MP0005385_cardiovascular_system_phenoty0.55118795
171MP0002086_abnormal_extraembryonic_tissu0.54261262
172MP0005275_abnormal_skin_tensile0.53681967
173MP0000467_abnormal_esophagus_morphology0.53243718

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)7.28059646
2Spontaneous hematomas (HP:0007420)6.96497577
3Protrusio acetabuli (HP:0003179)5.91514274
4Abnormality of the parietal bone (HP:0002696)5.48697504
5Esophageal varix (HP:0002040)5.27087320
6Conjunctival telangiectasia (HP:0000524)5.12875887
7Midline defect of the nose (HP:0004122)5.10921780
8Wrist flexion contracture (HP:0001239)5.03570013
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.02886580
10Degeneration of the lateral corticospinal tracts (HP:0002314)5.02886580
11Arterial tortuosity (HP:0005116)4.93933234
12Polycythemia (HP:0001901)4.90784778
13Alacrima (HP:0000522)4.87381649
14Cerebral hemorrhage (HP:0001342)4.78556676
15Vascular tortuosity (HP:0004948)4.73161094
16Anteriorly placed anus (HP:0001545)4.62356851
17Nasolacrimal duct obstruction (HP:0000579)4.38225823
18Skull defect (HP:0001362)4.29417640
19Portal hypertension (HP:0001409)4.28973242
20Neurofibrillary tangles (HP:0002185)4.12588351
21Abnormality of the hepatic vasculature (HP:0006707)4.03041910
22Abnormality of the vasculature of the conjunctiva (HP:0008054)3.97982608
23Aplasia involving bones of the upper limbs (HP:0009823)3.96774663
24Aplasia of the phalanges of the hand (HP:0009802)3.96774663
25Aplasia involving bones of the extremities (HP:0009825)3.96774663
26Adactyly (HP:0009776)3.86801984
27Decreased lacrimation (HP:0000633)3.83728432
28Parakeratosis (HP:0001036)3.80883816
29Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.76706964
30Visceral angiomatosis (HP:0100761)3.70380340
31Sensory axonal neuropathy (HP:0003390)3.64386929
32Premature rupture of membranes (HP:0001788)3.64127959
33Aortic valve stenosis (HP:0001650)3.59323638
34Abnormality of the corticospinal tract (HP:0002492)3.58901217
35Overgrowth (HP:0001548)3.58391103
36White forelock (HP:0002211)3.58114974
37Coronal craniosynostosis (HP:0004440)3.56715079
38Hemangiomatosis (HP:0007461)3.55559147
39Humeroradial synostosis (HP:0003041)3.53429091
40Synostosis involving the elbow (HP:0003938)3.53429091
41Aortic dissection (HP:0002647)3.51111471
42Abnormality of the nasal mucosa (HP:0000433)3.48840525
43Menorrhagia (HP:0000132)3.44784774
44Partial duplication of thumb phalanx (HP:0009944)3.44653559
45Abnormality of the lacrimal duct (HP:0011481)3.37875927
46Trigonocephaly (HP:0000243)3.35569596
47Short 4th metacarpal (HP:0010044)3.32275238
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32275238
49Patchy hypopigmentation of hair (HP:0011365)3.31054944
50Infantile muscular hypotonia (HP:0008947)3.29866389
51Aortic aneurysm (HP:0004942)3.25958807
52Abnormality of the intrinsic pathway (HP:0010989)3.24793724
53Abnormality of the nasolacrimal system (HP:0000614)3.24342573
54Spinal rigidity (HP:0003306)3.22425026
55Partial duplication of the phalanx of hand (HP:0009999)3.20284518
56Vertebral clefting (HP:0008428)3.19352296
57Broad metatarsal (HP:0001783)3.09589700
58Mitral valve prolapse (HP:0001634)3.08763448
59Premature skin wrinkling (HP:0100678)3.08262194
60Large earlobe (HP:0009748)3.00733040
61Mucosal telangiectasiae (HP:0100579)3.00577759
62Neoplasm of the heart (HP:0100544)2.95839916
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.88585649
64Hip contracture (HP:0003273)2.87490726
65Abnormality of the nasal septum (HP:0000419)2.82910517
66Lymphangioma (HP:0100764)2.80237779
67Nonimmune hydrops fetalis (HP:0001790)2.80029529
68Cerebral inclusion bodies (HP:0100314)2.79872470
69Myotonia (HP:0002486)2.78200703
70Abnormal vertebral ossification (HP:0100569)2.76199753
71Abnormality of the middle phalanges of the toes (HP:0010183)2.75510673
72Venous insufficiency (HP:0005293)2.75015261
73Cavernous hemangioma (HP:0001048)2.71517693
74Joint hemorrhage (HP:0005261)2.68386208
75Bell-shaped thorax (HP:0001591)2.67329407
76Neonatal death (HP:0003811)2.65411762
77Abnormality of the distal phalanx of the thumb (HP:0009617)2.62229968
78Cervical subluxation (HP:0003308)2.60904905
79Peripheral hypomyelination (HP:0007182)2.58993843
80Abnormality of incisor morphology (HP:0011063)2.58259592
81Pulmonary hypertension (HP:0002092)2.58192995
82Depressed nasal tip (HP:0000437)2.58179485
83Limited hip movement (HP:0008800)2.57820959
84Flexion contracture of toe (HP:0005830)2.56792135
85Joint contractures involving the joints of the feet (HP:0100492)2.56792135
86Absent hand (HP:0004050)2.56786424
87Onion bulb formation (HP:0003383)2.56257743
88Toxemia of pregnancy (HP:0100603)2.54985103
89Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51530142
90High pitched voice (HP:0001620)2.49732244
91Recurrent corneal erosions (HP:0000495)2.49675022
92Turricephaly (HP:0000262)2.46416291
93Cupped ear (HP:0000378)2.46313856
94Abnormality of the diencephalon (HP:0010662)2.45997695
95Shallow orbits (HP:0000586)2.40791990
96Aqueductal stenosis (HP:0002410)2.40687996
97Broad face (HP:0000283)2.40163408
98Insidious onset (HP:0003587)2.39075281
99Termporal pattern (HP:0011008)2.39075281
100Thickened helices (HP:0000391)2.37208734
101Spastic gait (HP:0002064)2.36619108
102Cerebral aneurysm (HP:0004944)2.36224429
103Concave nail (HP:0001598)2.35580674
104Abnormality of the 4th metacarpal (HP:0010012)2.33312138
105Conical tooth (HP:0000698)2.31785118
106Mixed hearing impairment (HP:0000410)2.28664509
107Wormian bones (HP:0002645)2.28022468
108Abnormal platelet function (HP:0011869)2.27782414
109Impaired platelet aggregation (HP:0003540)2.27782414
110Absent septum pellucidum (HP:0001331)2.26298066
111Porencephaly (HP:0002132)2.25777818
112Meningioma (HP:0002858)2.25624309
113Rectal fistula (HP:0100590)2.23435126
114Rectovaginal fistula (HP:0000143)2.23435126
115Aplasia cutis congenita (HP:0001057)2.23419148
116Ectopia lentis (HP:0001083)2.18693444
117Intention tremor (HP:0002080)2.17097129
118Abnormal auditory evoked potentials (HP:0006958)2.16886628
119Pigmentary retinal degeneration (HP:0001146)2.13046042
120Flat face (HP:0012368)2.12800200
121Venous abnormality (HP:0002624)2.11541426
122Subcapsular cataract (HP:0000523)2.11540405
123Bulbous nose (HP:0000414)2.11517147
124Abnormality of the anterior chamber (HP:0000593)2.10160581
125Sparse lateral eyebrow (HP:0005338)2.09906237
126Abnormality of the incisor (HP:0000676)2.09814877
127Abnormality of the labia minora (HP:0012880)2.08764328
128Vitreoretinal degeneration (HP:0000655)2.07518153
129Camptodactyly of toe (HP:0001836)2.05954112
130Duplication of thumb phalanx (HP:0009942)2.05823739
131Supranuclear gaze palsy (HP:0000605)2.04363007
132Neoplasm of the oral cavity (HP:0100649)2.03919052
133Split foot (HP:0001839)2.02827454
134Intestinal polyposis (HP:0200008)1.99684794
135Abnormality of the salivary glands (HP:0010286)1.99650555
136Supernumerary ribs (HP:0005815)1.97007089
137Short phalanx of the thumb (HP:0009660)1.95500758
138Bronchomalacia (HP:0002780)1.94113947
139Abnormality of the acetabulum (HP:0003170)1.93099643
140Pulmonic stenosis (HP:0001642)1.92713448
141Incomplete penetrance (HP:0003829)1.90981103
142Hypoplasia of the iris (HP:0007676)1.90732292
143Coxa vara (HP:0002812)1.89905894
144Full cheeks (HP:0000293)1.89602751
145Intestinal polyp (HP:0005266)1.89064999
146Reduced subcutaneous adipose tissue (HP:0003758)1.88602028
147Bifid uvula (HP:0000193)1.88312753
148Abnormality of the septum pellucidum (HP:0007375)1.88188079
149Short hallux (HP:0010109)1.86925775
150Stenosis of the external auditory canal (HP:0000402)1.86325321
151Bifid scrotum (HP:0000048)1.85885025
152Intestinal fistula (HP:0100819)1.85630993
153Dysmetria (HP:0001310)1.85094277
154Hypoplastic pelvis (HP:0008839)1.84807334
155Disproportionate tall stature (HP:0001519)1.84505430
156Vaginal fistula (HP:0004320)1.84228738
157Preaxial foot polydactyly (HP:0001841)1.83124817
158Abnormality of the proximal phalanges of the hand (HP:0009834)1.82940424
159Xerostomia (HP:0000217)1.82289628
160Blue irides (HP:0000635)1.81306533
161Microglossia (HP:0000171)1.81223207
162Esophageal atresia (HP:0002032)1.81077382
163Short nail (HP:0001799)1.80152709
164Glossoptosis (HP:0000162)1.79673969
165Stroke (HP:0001297)1.79455652
166Scanning speech (HP:0002168)1.79311239
167Benign neoplasm of the central nervous system (HP:0100835)1.79162493
168Megalencephaly (HP:0001355)1.79098576
169Fibular aplasia (HP:0002990)1.78996918
170Abnormality of the antihelix (HP:0009738)1.78545401
171Supernumerary bones of the axial skeleton (HP:0009144)1.78270574
172Pheochromocytoma (HP:0002666)1.78227337
173Abnormality of the middle phalanges of the hand (HP:0009833)1.78155982
174Congenital hip dislocation (HP:0001374)1.77657226
175Focal seizures (HP:0007359)1.77500540
176Aneurysm (HP:0002617)1.76309078
177Abnormal number of incisors (HP:0011064)1.74393759
178Anophthalmia (HP:0000528)1.73855702
179Tetraparesis (HP:0002273)1.73249007
180Microcytic anemia (HP:0001935)1.72550254
181Atonic seizures (HP:0010819)1.71265954
182Congenital glaucoma (HP:0001087)1.69805444
183Anterior segment dysgenesis (HP:0007700)1.69679942
184Hemorrhage of the eye (HP:0011885)1.68749362
185Spondylolisthesis (HP:0003302)1.68347593
186Long eyelashes (HP:0000527)1.67584009
187Blue sclerae (HP:0000592)1.66840130
188Fused cervical vertebrae (HP:0002949)1.66819701
189Ankyloglossia (HP:0010296)1.65880377
190Coxa valga (HP:0002673)1.65547873
191Abnormality of the right ventricle (HP:0001707)1.65389499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.13360618
2TGFBR25.52451540
3OXSR14.23207119
4FGFR24.21311003
5EPHB13.35299788
6TGFBR13.18181193
7KDR2.95249611
8BCR2.76065365
9PRPF4B2.67405506
10MET2.23293140
11WNK42.21457066
12PKN12.20865547
13FES2.19401560
14LATS12.12227492
15PBK2.09457290
16MAPKAPK52.08670341
17WNK12.08145562
18PTK22.07596220
19PTK2B2.04942501
20CSNK1A1L2.03445942
21TIE112.8487679
22FER1.97410444
23CDK191.92070207
24TNIK1.90397283
25PNCK1.81095260
26CSNK1G31.65361415
27CSNK1G11.50042851
28ICK1.48371772
29LIMK11.46679534
30TEC1.44564361
31NEK61.40706726
32DDR21.39502737
33UHMK11.38552077
34NTRK11.37331817
35ROCK21.36573086
36NUAK11.35954840
37CLK11.33406657
38CSNK1G21.23708357
39PAK61.20323362
40CAMK2B1.16993870
41EPHA41.12682740
42MAPK151.12659601
43PRKG21.07335915
44CASK1.06685473
45FGR1.05461577
46CAMK2D1.04269059
47CAMK1G1.02024256
48MST41.01509559
49MARK21.00363150
50PRKD31.00152512
51DYRK21.00096476
52PRKCQ0.98572368
53SGK4940.97890681
54SGK2230.97890681
55MAPKAPK30.97185078
56PIK3CA0.95062729
57LATS20.94970330
58BMPR1B0.93308958
59TYRO30.89722362
60RIPK10.89651441
61TESK20.85380758
62BMX0.84915120
63CDK80.83434824
64PAK30.80853973
65FGFR10.80193303
66PDGFRB0.77974132
67ERBB40.77829539
68MOS0.75618198
69MARK10.72618494
70PRKD10.70219930
71CAMK2G0.69658296
72MAP3K120.69145201
73PRKCE0.69019975
74NLK0.68668212
75PDGFRA0.68105012
76EPHA30.67202006
77PLK20.66752732
78DMPK0.64576957
79CDK50.63995584
80TTN0.61833064
81CAMK2A0.60305937
82GSK3A0.60052825
83CDK140.59959689
84CSNK1D0.56053560
85FYN0.54900977
86MAP3K130.52183734
87PHKG20.51896798
88PHKG10.51896798
89NEK90.48869133
90STK380.48258766
91CDK150.47969293
92FLT30.47737988
93PAK40.47725221
94MYLK0.47011597
95NTRK30.46837847
96RPS6KA20.45905323
97RPS6KA50.45590157
98DAPK30.45402972
99IRAK20.45179894
100PRKG10.44803452
101PRKCH0.43845359
102INSR0.42502736
103CDK180.42479755
104SGK20.42136241
105MAP2K20.42107996
106FRK0.41547712
107PDPK10.41517782
108CSNK1A10.41320497
109MELK0.39957519
110CDK11A0.39948568
111PRKACB0.38918370
112PTK60.38583588
113CAMK1D0.38577913
114MAPK70.38478290
115TRPM70.38382965
116STK110.38335277
117EPHA20.38008306
118DAPK20.36759108
119NTRK20.36307341
120STK30.35943698
121SRC0.35849020
122IRAK10.35017009
123ROCK10.34874491
124MAPK130.34602530
125SGK30.33849944
126MKNK10.33647195
127PAK20.32694451
128EGFR0.31514692
129EPHB20.31229951
130SIK10.28531750
131CDK90.28478454
132CSK0.27710528
133ITK0.27258189
134GRK50.26893082
135TAF10.26179463
136DAPK10.26049625
137PRKAA20.25317382
138MAP3K20.25204083
139IGF1R0.25194222
140CDK30.24558646
141MAPK100.24203167
142BRD40.23462883
143TNK20.23180345
144MAPK120.23150951
145MAP2K10.22697190
146HCK0.22202376
147GRK10.20615740
148PDK20.18036499
149STK100.16928255
150KSR10.16489434
151CAMKK20.15789713
152MTOR0.15291585
153ZAP700.14939431
154EEF2K0.14666212
155PINK10.14440473

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.07865280
2Steroid biosynthesis_Homo sapiens_hsa001005.02635582
3Fatty acid elongation_Homo sapiens_hsa000623.74688865
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48730819
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.19796640
6Ether lipid metabolism_Homo sapiens_hsa005652.92626396
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82061364
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20732006
9Adherens junction_Homo sapiens_hsa045202.14015161
10Axon guidance_Homo sapiens_hsa043602.11487065
11Sulfur metabolism_Homo sapiens_hsa009202.02878410
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.97902412
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87642012
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86371577
15Histidine metabolism_Homo sapiens_hsa003401.78330292
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.74843860
17* Hedgehog signaling pathway_Homo sapiens_hsa043401.73613061
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69976095
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61295849
20* Basal cell carcinoma_Homo sapiens_hsa052171.60689400
21Sphingolipid metabolism_Homo sapiens_hsa006001.50845096
22Butanoate metabolism_Homo sapiens_hsa006501.46000611
23Platelet activation_Homo sapiens_hsa046111.35602121
24ECM-receptor interaction_Homo sapiens_hsa045121.32163884
25Protein export_Homo sapiens_hsa030601.30429285
26Linoleic acid metabolism_Homo sapiens_hsa005911.29867289
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28685250
28Complement and coagulation cascades_Homo sapiens_hsa046101.26811789
29Small cell lung cancer_Homo sapiens_hsa052221.26088906
30Renal cell carcinoma_Homo sapiens_hsa052111.23959816
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15210192
32Bladder cancer_Homo sapiens_hsa052191.13883767
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11684502
34Serotonergic synapse_Homo sapiens_hsa047261.10074275
35Vitamin B6 metabolism_Homo sapiens_hsa007501.09327492
36Oxidative phosphorylation_Homo sapiens_hsa001901.07458420
37Wnt signaling pathway_Homo sapiens_hsa043101.06984159
38Tight junction_Homo sapiens_hsa045301.05815641
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05503511
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04947989
41MicroRNAs in cancer_Homo sapiens_hsa052061.03806312
42Glutamatergic synapse_Homo sapiens_hsa047241.03421271
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03407438
44Taste transduction_Homo sapiens_hsa047421.02725433
45Arginine and proline metabolism_Homo sapiens_hsa003301.02033396
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00763348
47Ras signaling pathway_Homo sapiens_hsa040140.97112753
48Nitrogen metabolism_Homo sapiens_hsa009100.96784148
49GABAergic synapse_Homo sapiens_hsa047270.96416121
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92829902
51Long-term depression_Homo sapiens_hsa047300.92578515
52Ovarian steroidogenesis_Homo sapiens_hsa049130.91971242
53Prion diseases_Homo sapiens_hsa050200.85852159
54Estrogen signaling pathway_Homo sapiens_hsa049150.85700833
55Nicotine addiction_Homo sapiens_hsa050330.85355559
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.85056638
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84371489
58Morphine addiction_Homo sapiens_hsa050320.83184545
59Glioma_Homo sapiens_hsa052140.82807503
60Long-term potentiation_Homo sapiens_hsa047200.81118542
61Selenocompound metabolism_Homo sapiens_hsa004500.79821889
62Alzheimers disease_Homo sapiens_hsa050100.79447357
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.79268577
64Cocaine addiction_Homo sapiens_hsa050300.79155994
65GnRH signaling pathway_Homo sapiens_hsa049120.78998063
66Endocytosis_Homo sapiens_hsa041440.77311321
67ErbB signaling pathway_Homo sapiens_hsa040120.76731494
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76218484
69Oxytocin signaling pathway_Homo sapiens_hsa049210.74394644
70African trypanosomiasis_Homo sapiens_hsa051430.73995113
71TGF-beta signaling pathway_Homo sapiens_hsa043500.72810928
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72415698
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.71848782
74Shigellosis_Homo sapiens_hsa051310.71844849
75Hippo signaling pathway_Homo sapiens_hsa043900.71496788
76Vitamin digestion and absorption_Homo sapiens_hsa049770.69864319
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69422776
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68375157
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.67025602
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66862561
81Renin secretion_Homo sapiens_hsa049240.66186403
82Pancreatic cancer_Homo sapiens_hsa052120.65867423
83Prostate cancer_Homo sapiens_hsa052150.65408497
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64556988
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63456390
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63347726
87Melanoma_Homo sapiens_hsa052180.62765955
88Thyroid hormone synthesis_Homo sapiens_hsa049180.62067582
89Salmonella infection_Homo sapiens_hsa051320.62037144
90Insulin secretion_Homo sapiens_hsa049110.61703009
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61689794
92Arachidonic acid metabolism_Homo sapiens_hsa005900.61151835
93VEGF signaling pathway_Homo sapiens_hsa043700.61149818
94Parkinsons disease_Homo sapiens_hsa050120.60863031
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60781043
96p53 signaling pathway_Homo sapiens_hsa041150.59916235
97Pertussis_Homo sapiens_hsa051330.59754554
98Chronic myeloid leukemia_Homo sapiens_hsa052200.59119786
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58703813
100Dorso-ventral axis formation_Homo sapiens_hsa043200.57972911
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57793701
102HIF-1 signaling pathway_Homo sapiens_hsa040660.57710598
103Cholinergic synapse_Homo sapiens_hsa047250.57491618
104Synaptic vesicle cycle_Homo sapiens_hsa047210.55865900
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55710487
106Mineral absorption_Homo sapiens_hsa049780.55650078
107Circadian entrainment_Homo sapiens_hsa047130.54483021
108Fatty acid metabolism_Homo sapiens_hsa012120.54367647
109Vibrio cholerae infection_Homo sapiens_hsa051100.54340726
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53739356
111Retinol metabolism_Homo sapiens_hsa008300.53701889
112* Pathways in cancer_Homo sapiens_hsa052000.53545900
113MAPK signaling pathway_Homo sapiens_hsa040100.52691887
114Calcium signaling pathway_Homo sapiens_hsa040200.52353299
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51954092
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51181278
117Glutathione metabolism_Homo sapiens_hsa004800.50441121
118Folate biosynthesis_Homo sapiens_hsa007900.50342928
119Salivary secretion_Homo sapiens_hsa049700.50256160
120Protein digestion and absorption_Homo sapiens_hsa049740.50168812
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50165002
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49778143
123* cAMP signaling pathway_Homo sapiens_hsa040240.49469068
124Autoimmune thyroid disease_Homo sapiens_hsa053200.49342711
125Focal adhesion_Homo sapiens_hsa045100.49038293
126Rap1 signaling pathway_Homo sapiens_hsa040150.47345767
127N-Glycan biosynthesis_Homo sapiens_hsa005100.45795371
128Melanogenesis_Homo sapiens_hsa049160.45160786
129Choline metabolism in cancer_Homo sapiens_hsa052310.44175503
130Dilated cardiomyopathy_Homo sapiens_hsa054140.44093259
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44051767
132Propanoate metabolism_Homo sapiens_hsa006400.43785075
133Malaria_Homo sapiens_hsa051440.43660727
134Gastric acid secretion_Homo sapiens_hsa049710.41847474
135Gap junction_Homo sapiens_hsa045400.39804843
136Dopaminergic synapse_Homo sapiens_hsa047280.38856137
137Proteoglycans in cancer_Homo sapiens_hsa052050.38282447
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.37842807
139Pancreatic secretion_Homo sapiens_hsa049720.37738466
140Phototransduction_Homo sapiens_hsa047440.37280851
141Rheumatoid arthritis_Homo sapiens_hsa053230.37037177
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36620069
143Chemical carcinogenesis_Homo sapiens_hsa052040.35764734
144Amoebiasis_Homo sapiens_hsa051460.34453396
145Peroxisome_Homo sapiens_hsa041460.33741389
146Tyrosine metabolism_Homo sapiens_hsa003500.33332545

Most similar genes based on co-expression Upload to Enrichr

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