HHIPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.95480422
2glutamate secretion (GO:0014047)4.99795207
3regulation of synaptic vesicle exocytosis (GO:2000300)4.81618479
4neuronal action potential propagation (GO:0019227)4.42672277
5chondrocyte proliferation (GO:0035988)4.39906452
6collagen fibril organization (GO:0030199)4.33163322
7negative regulation of synaptic transmission, GABAergic (GO:0032229)4.13572467
8plasma membrane repair (GO:0001778)4.12047365
9regulation of synaptic vesicle transport (GO:1902803)4.08545190
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05966386
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00426140
12postsynaptic membrane organization (GO:0001941)3.96163054
13protein localization to synapse (GO:0035418)3.87072085
14protein heterotrimerization (GO:0070208)3.82480883
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.82035841
16synaptic vesicle exocytosis (GO:0016079)3.81202273
17apoptotic cell clearance (GO:0043277)3.79395146
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.75288900
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.74867086
20axon extension involved in axon guidance (GO:0048846)3.74867086
21gonadal mesoderm development (GO:0007506)3.73917930
22sequestering of extracellular ligand from receptor (GO:0035581)3.65018513
23negative regulation of complement activation (GO:0045916)3.60657765
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.57319961
25regulation of neuronal synaptic plasticity (GO:0048168)3.56438297
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54451489
27presynaptic membrane assembly (GO:0097105)3.53320371
28endodermal cell differentiation (GO:0035987)3.51929568
29glutamate receptor signaling pathway (GO:0007215)3.50809670
30synaptic transmission, glutamatergic (GO:0035249)3.49788739
31positive regulation of neurotransmitter secretion (GO:0001956)3.48510477
32positive regulation of neurotransmitter transport (GO:0051590)3.45254279
33neuron-neuron synaptic transmission (GO:0007270)3.41858396
34dendritic spine morphogenesis (GO:0060997)3.41716771
35neuronal ion channel clustering (GO:0045161)3.38979806
36opsonization (GO:0008228)3.37906400
37gamma-aminobutyric acid transport (GO:0015812)3.32378837
38presynaptic membrane organization (GO:0097090)3.31871237
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31365984
40skin morphogenesis (GO:0043589)3.26646201
41negative regulation of protein activation cascade (GO:2000258)3.25323742
42neurotransmitter secretion (GO:0007269)3.24767937
43basement membrane organization (GO:0071711)3.22076806
44neuron cell-cell adhesion (GO:0007158)3.18126213
45cell adhesion mediated by integrin (GO:0033627)3.18006770
46regulation of neurotransmitter secretion (GO:0046928)3.17847845
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.13859532
48auditory behavior (GO:0031223)3.13805073
49transmission of nerve impulse (GO:0019226)3.13561834
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13199854
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12465687
52cerebellar Purkinje cell layer development (GO:0021680)3.09437473
53L-amino acid import (GO:0043092)3.08898152
54dermatan sulfate biosynthetic process (GO:0030208)3.08642574
55regulation of postsynaptic membrane potential (GO:0060078)3.08129104
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07638178
57regulation of neurotransmitter transport (GO:0051588)3.06334067
58synaptic vesicle endocytosis (GO:0048488)3.06230047
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06135110
60central nervous system projection neuron axonogenesis (GO:0021952)3.05439946
61regulation of glutamate receptor signaling pathway (GO:1900449)3.05415122
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04873315
63positive regulation of membrane potential (GO:0045838)3.03791416
64exploration behavior (GO:0035640)3.03101044
65peptidyl-proline hydroxylation (GO:0019511)2.96463209
66cellular potassium ion homeostasis (GO:0030007)2.94021368
67regulation of female receptivity (GO:0045924)2.93252434
68layer formation in cerebral cortex (GO:0021819)2.92088130
69mesenchymal-epithelial cell signaling (GO:0060638)2.90467789
70cerebellar granule cell differentiation (GO:0021707)2.89684726
71collagen metabolic process (GO:0032963)2.87797574
72negative regulation of fatty acid transport (GO:2000192)2.86824226
73membrane depolarization during action potential (GO:0086010)2.86657645
74neuron recognition (GO:0008038)2.86088821
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85775021
76startle response (GO:0001964)2.85307315
77collagen catabolic process (GO:0030574)2.84514328
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.83802322
79negative regulation of fibrinolysis (GO:0051918)2.82774111
80positive regulation of dendritic spine development (GO:0060999)2.81160264
81dermatan sulfate metabolic process (GO:0030205)2.79467025
82righting reflex (GO:0060013)2.79362207
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77810952
84locomotory exploration behavior (GO:0035641)2.76949843
85dendritic spine organization (GO:0097061)2.75723434
86positive regulation of axon extension (GO:0045773)2.75513531
87serotonin metabolic process (GO:0042428)2.75044986
88tachykinin receptor signaling pathway (GO:0007217)2.73510990
89positive regulation of synapse assembly (GO:0051965)2.73348023
90vocalization behavior (GO:0071625)2.73155203
91cell communication by electrical coupling (GO:0010644)2.73125861
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.73052165
93multicellular organismal macromolecule metabolic process (GO:0044259)2.72930638
94bone trabecula formation (GO:0060346)2.72808153
95regulation of dendritic spine morphogenesis (GO:0061001)2.72617128
96melanin biosynthetic process (GO:0042438)2.72369380
97protein hydroxylation (GO:0018126)2.72032527
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71320491
99axonal fasciculation (GO:0007413)2.71152683
100regulation of synaptic plasticity (GO:0048167)2.70492353
101retinal cone cell development (GO:0046549)2.70264708
102adherens junction assembly (GO:0034333)2.69909574
103neurotransmitter transport (GO:0006836)2.69387370
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.69386269
105membrane depolarization (GO:0051899)2.69361157
106regulation of dendritic spine development (GO:0060998)2.67878074
107adult walking behavior (GO:0007628)2.66926753
108regulation of tight junction assembly (GO:2000810)2.66389717
109establishment of nucleus localization (GO:0040023)2.66321458
110pyrimidine nucleobase catabolic process (GO:0006208)2.65017819
111establishment of mitochondrion localization (GO:0051654)2.64702342
112alanine transport (GO:0032328)2.63702309
113brain morphogenesis (GO:0048854)2.63025306
114amino acid import (GO:0043090)2.62397392
115regulation of neurotransmitter uptake (GO:0051580)2.61812529
116proline transport (GO:0015824)2.61375247
117stress fiber assembly (GO:0043149)2.61326433
118central nervous system neuron axonogenesis (GO:0021955)2.61097176
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61039384
120phosphorelay signal transduction system (GO:0000160)2.60261345
121multicellular organismal catabolic process (GO:0044243)2.58571152
122acidic amino acid transport (GO:0015800)2.57840657
123microtubule severing (GO:0051013)2.57511786
124regulation of voltage-gated calcium channel activity (GO:1901385)2.57081403
125central nervous system myelination (GO:0022010)2.57073285
126axon ensheathment in central nervous system (GO:0032291)2.57073285
127multicellular organismal metabolic process (GO:0044236)2.55815662
128C4-dicarboxylate transport (GO:0015740)2.55254365
129cell-substrate junction assembly (GO:0007044)2.54853918
130female mating behavior (GO:0060180)2.54416687
131dendrite morphogenesis (GO:0048813)2.53590140
132chondroitin sulfate catabolic process (GO:0030207)2.52487268
133regulation of fatty acid beta-oxidation (GO:0031998)2.52339088
134positive regulation of fibroblast migration (GO:0010763)2.50855167
135craniofacial suture morphogenesis (GO:0097094)2.50633583
136regulation of neurotransmitter levels (GO:0001505)2.50190860
137regulation of synaptic transmission (GO:0050804)2.50046610
138cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49823354
139synaptic vesicle maturation (GO:0016188)2.49420008
140intraspecies interaction between organisms (GO:0051703)2.49105470
141social behavior (GO:0035176)2.49105470
142neurotransmitter-gated ion channel clustering (GO:0072578)2.48704285
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48053611
144primary amino compound metabolic process (GO:1901160)2.47335776
145positive regulation of macrophage activation (GO:0043032)2.46919441
146urinary tract smooth muscle contraction (GO:0014848)2.46517238
147extracellular matrix disassembly (GO:0022617)2.45616347
148cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.44663425
149regulation of complement activation (GO:0030449)2.41419969
150vascular endothelial growth factor signaling pathway (GO:0038084)2.39962315
151cell-substrate adherens junction assembly (GO:0007045)2.39517982
152focal adhesion assembly (GO:0048041)2.39517982
153regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38715733
154heparan sulfate proteoglycan metabolic process (GO:0030201)2.38629506
155axon extension (GO:0048675)2.38055448
156positive regulation of fatty acid beta-oxidation (GO:0032000)2.36013722
157regulation of protein activation cascade (GO:2000257)2.35436413
158glial cell migration (GO:0008347)2.34412506
159cardiac myofibril assembly (GO:0055003)2.32733380
160insulin-like growth factor receptor signaling pathway (GO:0048009)2.32474637
161alpha-linolenic acid metabolic process (GO:0036109)2.31185290
162sodium ion export (GO:0071436)2.30956849
163negative regulation of catenin import into nucleus (GO:0035414)2.30147339
164protein targeting to plasma membrane (GO:0072661)2.29842770
165lung epithelium development (GO:0060428)2.29773121
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29725294
167melanin metabolic process (GO:0006582)2.27410900
168negative regulation of lipid transport (GO:0032369)2.27165251
169positive regulation of glycogen biosynthetic process (GO:0045725)2.26844534
170secondary metabolite biosynthetic process (GO:0044550)2.25464149
1714-hydroxyproline metabolic process (GO:0019471)2.25082341
172regulation of apoptotic cell clearance (GO:2000425)2.23057134
173regulation of fibrinolysis (GO:0051917)2.22443851
174extracellular fibril organization (GO:0043206)2.21481541
175regulation of plasminogen activation (GO:0010755)2.20444862
176regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.18743550
177positive regulation of endothelial cell apoptotic process (GO:2000353)2.17709917
178chondroitin sulfate biosynthetic process (GO:0030206)2.16502674
179regulation of synapse structural plasticity (GO:0051823)2.14897158
180cardiac muscle cell proliferation (GO:0060038)2.14569135
181semaphorin-plexin signaling pathway (GO:0071526)2.12888269
182endothelial cell morphogenesis (GO:0001886)2.12823386
183negative regulation of cell junction assembly (GO:1901889)2.12323490
184negative regulation of adherens junction organization (GO:1903392)2.12323490
185negative regulation of focal adhesion assembly (GO:0051895)2.12323490
186negative regulation of potassium ion transmembrane transport (GO:1901380)2.12001529
187positive regulation of p38MAPK cascade (GO:1900745)2.11809324
188neuron projection extension (GO:1990138)2.10030969
189cellular modified amino acid catabolic process (GO:0042219)2.09862547
190cell migration involved in sprouting angiogenesis (GO:0002042)2.09653107
191regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.09487337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.32417828
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.90163578
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.60637305
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50554159
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38450010
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38450010
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24028925
8REST_21632747_ChIP-Seq_MESCs_Mouse2.20953669
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.19031668
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14790620
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12805037
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10883942
13EZH2_22144423_ChIP-Seq_EOC_Human2.08855932
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06470369
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06243038
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06126756
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01086026
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96811739
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96793184
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96700246
21DROSHA_22980978_ChIP-Seq_HELA_Human1.90643143
22* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88656370
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88090614
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85708041
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82269154
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80891335
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80181386
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77344026
29CLOCK_20551151_ChIP-Seq_293T_Human1.75032236
30* EZH2_27304074_Chip-Seq_ESCs_Mouse1.74887487
31SMAD4_21799915_ChIP-Seq_A2780_Human1.73187055
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71650839
33P300_19829295_ChIP-Seq_ESCs_Human1.70151973
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.66450204
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.66048145
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.65060032
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.64108863
38* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63663325
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63251507
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59500423
41* EZH2_27294783_Chip-Seq_ESCs_Mouse1.59384167
42* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58593018
43GBX2_23144817_ChIP-Seq_PC3_Human1.56984239
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53401554
45* RXR_22158963_ChIP-Seq_LIVER_Mouse1.52394519
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49643855
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49477878
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48197156
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47936788
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.46333448
51TAF15_26573619_Chip-Seq_HEK293_Human1.45646862
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44801000
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44231007
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44080109
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43645819
56KDM2B_26808549_Chip-Seq_K562_Human1.39036318
57CJUN_26792858_Chip-Seq_BT549_Human1.38973469
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38591443
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38550254
60IGF1R_20145208_ChIP-Seq_DFB_Human1.38010962
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37203757
62AR_21572438_ChIP-Seq_LNCaP_Human1.36436569
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35113395
64* STAT3_23295773_ChIP-Seq_U87_Human1.35036354
65* LXR_22158963_ChIP-Seq_LIVER_Mouse1.33828969
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33322819
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.32318796
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32141281
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31884400
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31288450
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31205599
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30519709
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29841394
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29372983
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29120041
76TCF4_23295773_ChIP-Seq_U87_Human1.28377968
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27135697
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.26782738
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26342221
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26342221
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.24194018
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23664037
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.22867815
84AR_25329375_ChIP-Seq_VCAP_Human1.22746986
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.21435561
86RNF2_27304074_Chip-Seq_NSC_Mouse1.21394827
87TP53_18474530_ChIP-ChIP_U2OS_Human1.21313616
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20267780
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20016774
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20004007
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19376527
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19104808
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18692253
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17238948
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15760891
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15084131
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13564838
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13215501
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12507923
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12030732
101LXR_22292898_ChIP-Seq_THP-1_Human1.11427347
102FUS_26573619_Chip-Seq_HEK293_Human1.10865827
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10320760
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10131743
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09910572
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09910572
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09114285
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.08720571
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08367184
110BCAT_22108803_ChIP-Seq_LS180_Human1.08123725
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06695718
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04657819
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.04428074
114* RUNX2_22187159_ChIP-Seq_PCA_Human1.03760605
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.03760148
116* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03464941
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03400372
118TP53_16413492_ChIP-PET_HCT116_Human1.03124827
119TCF4_22108803_ChIP-Seq_LS180_Human1.02965422
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02847498
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.02356519
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.02356519
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01996682
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01847695
125* KDM2B_26808549_Chip-Seq_REH_Human1.01288637
126ZNF274_21170338_ChIP-Seq_K562_Hela1.00867412
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00492254
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99541504
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99148868
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.99133838
131VDR_22108803_ChIP-Seq_LS180_Human0.98912320
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98883818
133* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98840038
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.98755449
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.98728856
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97433261
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.97262505
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97207071
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96984479
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96797336
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.96339381
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96190532
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.95562006
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95528827
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94676377
146AR_19668381_ChIP-Seq_PC3_Human0.94399552
147BRD4_25478319_ChIP-Seq_HGPS_Human0.94177170
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.93758667
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.93586996
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93432002
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.90452263
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.89807321
153RACK7_27058665_Chip-Seq_MCF-7_Human0.89216934
154SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88478733
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.88387583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.60062279
2MP0003705_abnormal_hypodermis_morpholog4.25639853
3MP0003880_abnormal_central_pattern3.93351391
4MP0005275_abnormal_skin_tensile3.70065136
5MP0003279_aneurysm3.69009481
6MP0005503_abnormal_tendon_morphology3.42865206
7MP0005623_abnormal_meninges_morphology2.87011540
8MP0001958_emphysema2.78871898
9MP0005171_absent_coat_pigmentation2.55735665
10MP0001486_abnormal_startle_reflex2.52590599
11MP0002064_seizures2.48848612
12MP0005423_abnormal_somatic_nervous2.48112113
13MP0009745_abnormal_behavioral_response2.47792466
14MP0003283_abnormal_digestive_organ2.41784844
15MP0001968_abnormal_touch/_nociception2.38819998
16MP0004859_abnormal_synaptic_plasticity2.38368713
17MP0002272_abnormal_nervous_system2.30762897
18MP0009046_muscle_twitch2.28391484
19MP0002572_abnormal_emotion/affect_behav2.26819759
20MP0001501_abnormal_sleep_pattern2.26399900
21MP0000751_myopathy2.24658711
22MP0006276_abnormal_autonomic_nervous2.23551444
23MP0006054_spinal_hemorrhage2.21128277
24MP0009384_cardiac_valve_regurgitation2.16202969
25MP0002734_abnormal_mechanical_nocicepti2.13131703
26MP0004272_abnormal_basement_membrane2.10620709
27MP0000013_abnormal_adipose_tissue2.09024488
28MP0004858_abnormal_nervous_system2.03299253
29MP0002736_abnormal_nociception_after2.01133477
30MP0005257_abnormal_intraocular_pressure1.95547644
31MP0003879_abnormal_hair_cell1.90797853
32MP0001970_abnormal_pain_threshold1.80842469
33MP0001984_abnormal_olfaction1.79240913
34MP0003787_abnormal_imprinting1.78089149
35MP0003566_abnormal_cell_adhesion1.75816603
36MP0003329_amyloid_beta_deposits1.75140464
37MP0000778_abnormal_nervous_system1.71858198
38MP0002295_abnormal_pulmonary_circulatio1.71226305
39MP0002735_abnormal_chemical_nociception1.66973059
40MP0003122_maternal_imprinting1.66076232
41MP0003091_abnormal_cell_migration1.64353346
42MP0005551_abnormal_eye_electrophysiolog1.63053399
43MP0004885_abnormal_endolymph1.62877983
44MP0005508_abnormal_skeleton_morphology1.52293851
45MP0002557_abnormal_social/conspecific_i1.48074711
46MP0002837_dystrophic_cardiac_calcinosis1.48024605
47MP0003633_abnormal_nervous_system1.47809557
48MP0002733_abnormal_thermal_nociception1.47041718
49MP0005646_abnormal_pituitary_gland1.45907314
50MP0001299_abnormal_eye_distance/1.45708053
51MP0008569_lethality_at_weaning1.42111357
52MP0002067_abnormal_sensory_capabilities1.40447048
53MP0001188_hyperpigmentation1.40092143
54MP0010030_abnormal_orbit_morphology1.37323957
55MP0005386_behavior/neurological_phenoty1.36622513
56MP0004924_abnormal_behavior1.36622513
57MP0005023_abnormal_wound_healing1.31537657
58MP0000733_abnormal_muscle_development1.28128692
59MP0001529_abnormal_vocalization1.26994900
60MP0002882_abnormal_neuron_morphology1.26387395
61MP0004084_abnormal_cardiac_muscle1.26177668
62MP0004811_abnormal_neuron_physiology1.25534290
63MP0002108_abnormal_muscle_morphology1.24194699
64MP0005360_urolithiasis1.23700971
65MP0002896_abnormal_bone_mineralization1.21415517
66MP0010386_abnormal_urinary_bladder1.21395393
67MP0003115_abnormal_respiratory_system1.20434257
68MP0002877_abnormal_melanocyte_morpholog1.19648635
69MP0002060_abnormal_skin_morphology1.19314715
70MP0003385_abnormal_body_wall1.18957033
71MP0000604_amyloidosis1.17822353
72MP0008877_abnormal_DNA_methylation1.17613685
73MP0000372_irregular_coat_pigmentation1.14457631
74MP0000767_abnormal_smooth_muscle1.14119068
75MP0002066_abnormal_motor_capabilities/c1.13624546
76MP0003631_nervous_system_phenotype1.10788508
77MP0000955_abnormal_spinal_cord1.09238394
78MP0003045_fibrosis1.08660734
79MP0003252_abnormal_bile_duct1.08473094
80MP0009780_abnormal_chondrocyte_physiolo1.08304739
81MP0003136_yellow_coat_color1.05073894
82MP0001440_abnormal_grooming_behavior1.04997761
83MP0002184_abnormal_innervation1.04518685
84MP0000749_muscle_degeneration1.03808820
85MP0003635_abnormal_synaptic_transmissio1.03804190
86MP0004233_abnormal_muscle_weight1.03580165
87MP0002234_abnormal_pharynx_morphology1.03429828
88MP0005248_abnormal_Harderian_gland1.01587319
89MP0000003_abnormal_adipose_tissue1.01239713
90MP0004087_abnormal_muscle_fiber1.01132241
91MP0001502_abnormal_circadian_rhythm1.00328391
92MP0000534_abnormal_ureter_morphology1.00243859
93MP0001905_abnormal_dopamine_level0.99336119
94MP0000759_abnormal_skeletal_muscle0.99037262
95MP0002139_abnormal_hepatobiliary_system0.98391937
96MP0001963_abnormal_hearing_physiology0.97808732
97MP0010368_abnormal_lymphatic_system0.95585859
98MP0002282_abnormal_trachea_morphology0.94800293
99MP0000750_abnormal_muscle_regeneration0.94675165
100MP0009053_abnormal_anal_canal0.94625800
101MP0009250_abnormal_appendicular_skeleto0.94530994
102MP0001177_atelectasis0.94461871
103MP0004147_increased_porphyrin_level0.93560680
104MP0006138_congestive_heart_failure0.93250318
105MP0004036_abnormal_muscle_relaxation0.93246694
106MP0004742_abnormal_vestibular_system0.92958226
107MP0002089_abnormal_postnatal_growth/wei0.92022531
108MP0000428_abnormal_craniofacial_morphol0.90627845
109MP0002090_abnormal_vision0.90545373
110MP0001485_abnormal_pinna_reflex0.90037137
111MP0002229_neurodegeneration0.89599469
112MP0002254_reproductive_system_inflammat0.89341828
113MP0003690_abnormal_glial_cell0.88933996
114MP0004215_abnormal_myocardial_fiber0.88379790
115MP0002152_abnormal_brain_morphology0.88054117
116MP0005174_abnormal_tail_pigmentation0.85096173
117MP0002102_abnormal_ear_morphology0.84670896
118MP0003011_delayed_dark_adaptation0.83982575
119MP0000747_muscle_weakness0.83458888
120MP0005330_cardiomyopathy0.83448023
121MP0002168_other_aberrant_phenotype0.83386504
122MP0002752_abnormal_somatic_nervous0.82042858
123MP0004130_abnormal_muscle_cell0.81338690
124MP0004142_abnormal_muscle_tone0.81210281
125MP0002128_abnormal_blood_circulation0.80677082
126MP0009840_abnormal_foam_cell0.80168073
127MP0001243_abnormal_dermal_layer0.79918308
128MP0001542_abnormal_bone_strength0.79601228
129MP0000569_abnormal_digit_pigmentation0.79240442
130MP0005164_abnormal_response_to0.78627757
131MP0005595_abnormal_vascular_smooth0.76868431
132MP0002269_muscular_atrophy0.76350940
133MP0005620_abnormal_muscle_contractility0.73916623
134MP0003300_gastrointestinal_ulcer0.73910864
135MP0000920_abnormal_myelination0.73397714
136MP0000163_abnormal_cartilage_morphology0.73152414
137MP0002998_abnormal_bone_remodeling0.73088839
138MP0003942_abnormal_urinary_system0.69511372
139MP0002932_abnormal_joint_morphology0.69505634
140MP0003075_altered_response_to0.69261363
141MP0002115_abnormal_skeleton_extremities0.68905200
142MP0008775_abnormal_heart_ventricle0.68706480
143MP0005197_abnormal_uvea_morphology0.68509599
144MP0000026_abnormal_inner_ear0.68434715
145MP0000631_abnormal_neuroendocrine_gland0.67962096
146MP0005253_abnormal_eye_physiology0.67539723
147MP0000427_abnormal_hair_cycle0.66754107
148MP0000230_abnormal_systemic_arterial0.65669778
149MP0004043_abnormal_pH_regulation0.65466091
150MP0005394_taste/olfaction_phenotype0.64821089
151MP0005499_abnormal_olfactory_system0.64821089
152MP0005369_muscle_phenotype0.64663437
153MP0003172_abnormal_lysosome_physiology0.64034833
154MP0004883_abnormal_blood_vessel0.63623202
155MP0003121_genomic_imprinting0.63594178
156MP0002972_abnormal_cardiac_muscle0.62861715
157MP0005408_hypopigmentation0.61895497
158MP0002638_abnormal_pupillary_reflex0.61626785
159MP0003634_abnormal_glial_cell0.60859168
160MP0003632_abnormal_nervous_system0.60567931
161MP0005085_abnormal_gallbladder_physiolo0.60463942
162MP0003137_abnormal_impulse_conducting0.60276809
163MP0004085_abnormal_heartbeat0.60206037
164MP0005409_darkened_coat_color0.60084453
165MP0002069_abnormal_eating/drinking_beha0.59696480
166MP0010630_abnormal_cardiac_muscle0.58632641
167MP0001614_abnormal_blood_vessel0.58067609
168MP0002063_abnormal_learning/memory/cond0.57281371
169MP0004270_analgesia0.56936818
170MP0002909_abnormal_adrenal_gland0.56524458

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.52565247
2Protrusio acetabuli (HP:0003179)6.95427245
3Focal motor seizures (HP:0011153)5.25618766
4Focal seizures (HP:0007359)5.00600783
5Myokymia (HP:0002411)4.87698636
6Aortic dissection (HP:0002647)4.49778056
7Shallow orbits (HP:0000586)4.35309162
8Cerebral aneurysm (HP:0004944)4.30990232
9Febrile seizures (HP:0002373)4.25593819
10Ankle contracture (HP:0006466)4.15622179
11Broad metatarsal (HP:0001783)4.15291129
12Epileptic encephalopathy (HP:0200134)3.95634063
13Peritonitis (HP:0002586)3.90727373
14Soft skin (HP:0000977)3.66588984
15Progressive cerebellar ataxia (HP:0002073)3.63159703
16Bladder diverticulum (HP:0000015)3.58002545
17Action tremor (HP:0002345)3.46125015
18Atrophic scars (HP:0001075)3.39534020
19Fragile skin (HP:0001030)3.38352321
20Aortic aneurysm (HP:0004942)3.38018435
21Atonic seizures (HP:0010819)3.32698906
22Hemiparesis (HP:0001269)3.30374191
23Cervical subluxation (HP:0003308)3.23264733
24Dilatation of the ascending aorta (HP:0005111)3.10930783
25Type 1 muscle fiber predominance (HP:0003803)3.03241634
26Genu recurvatum (HP:0002816)3.03006039
27Increased connective tissue (HP:0009025)3.02328021
28Torticollis (HP:0000473)2.99434088
29Blue sclerae (HP:0000592)2.94311264
30Ankle clonus (HP:0011448)2.92730968
31Wrist flexion contracture (HP:0001239)2.91569479
32Mitral valve prolapse (HP:0001634)2.90180805
33Dialeptic seizures (HP:0011146)2.85396070
34Neonatal short-limb short stature (HP:0008921)2.80919995
35Polyphagia (HP:0002591)2.80424834
36Abnormality of dentin (HP:0010299)2.77776517
37Biconcave vertebral bodies (HP:0004586)2.77686454
38Generalized tonic-clonic seizures (HP:0002069)2.77578175
39Wormian bones (HP:0002645)2.77556775
40Spinal rigidity (HP:0003306)2.76083465
41Abnormal eating behavior (HP:0100738)2.74978455
42Supranuclear gaze palsy (HP:0000605)2.73261318
43Limb dystonia (HP:0002451)2.73034415
44Gait imbalance (HP:0002141)2.69523076
45Increased variability in muscle fiber diameter (HP:0003557)2.68224764
46Vertebral compression fractures (HP:0002953)2.66129143
47Vascular tortuosity (HP:0004948)2.65026197
48Hyperextensible skin (HP:0000974)2.62766693
49Arterial tortuosity (HP:0005116)2.61751594
50Abnormal delivery (HP:0001787)2.60185486
51Mild short stature (HP:0003502)2.59321181
52Gaze-evoked nystagmus (HP:0000640)2.56788521
53Genetic anticipation (HP:0003743)2.55742452
54Hyperventilation (HP:0002883)2.53847102
55Coronal craniosynostosis (HP:0004440)2.53674667
56Congenital stationary night blindness (HP:0007642)2.51716690
57Upper limb amyotrophy (HP:0009129)2.51270402
58Distal upper limb amyotrophy (HP:0007149)2.51270402
59Bowel diverticulosis (HP:0005222)2.50242702
60Absence seizures (HP:0002121)2.48276517
61Epileptiform EEG discharges (HP:0011182)2.48110868
62Ulnar bowing (HP:0003031)2.47869256
63Turricephaly (HP:0000262)2.45369223
64Spastic gait (HP:0002064)2.42430435
65Deep venous thrombosis (HP:0002625)2.41310865
66Focal dystonia (HP:0004373)2.40900550
67Aneurysm (HP:0002617)2.35850048
68Infantile muscular hypotonia (HP:0008947)2.34986833
69Urinary bladder sphincter dysfunction (HP:0002839)2.33107061
70Follicular hyperkeratosis (HP:0007502)2.32769665
71Aplasia of the phalanges of the hand (HP:0009802)2.28838012
72Aplasia involving bones of the extremities (HP:0009825)2.28838012
73Aplasia involving bones of the upper limbs (HP:0009823)2.28838012
74Abnormality of binocular vision (HP:0011514)2.28731591
75Diplopia (HP:0000651)2.28731591
76EEG with generalized epileptiform discharges (HP:0011198)2.28020547
77Overgrowth (HP:0001548)2.25581246
78Drooling (HP:0002307)2.25430748
79Progressive inability to walk (HP:0002505)2.24451839
80Mildly elevated creatine phosphokinase (HP:0008180)2.23535769
81Craniofacial dystonia (HP:0012179)2.22486449
82Abnormality of skeletal muscle fiber size (HP:0012084)2.20775164
83Scapular winging (HP:0003691)2.20381820
84Slender build (HP:0001533)2.20190564
85Hyporeflexia of lower limbs (HP:0002600)2.19963748
86Congenital primary aphakia (HP:0007707)2.18668409
87Lower limb amyotrophy (HP:0007210)2.17088495
88Wide anterior fontanel (HP:0000260)2.16828316
89Hypoventilation (HP:0002791)2.16518827
90Abnormality of the acetabulum (HP:0003170)2.15933242
91Impaired vibration sensation in the lower limbs (HP:0002166)2.14629697
92Hypsarrhythmia (HP:0002521)2.14387099
93Achilles tendon contracture (HP:0001771)2.14297085
94Lower limb muscle weakness (HP:0007340)2.12041461
95Medial flaring of the eyebrow (HP:0010747)2.10851674
96Difficulty climbing stairs (HP:0003551)2.10146103
97Spondylolisthesis (HP:0003302)2.10121900
98Nephrogenic diabetes insipidus (HP:0009806)2.09484814
99Abnormality of the Achilles tendon (HP:0005109)2.09028295
100Metaphyseal dysplasia (HP:0100255)2.08869635
101Radial bowing (HP:0002986)2.08496359
102Abnormality of the lower motor neuron (HP:0002366)2.07505354
103Truncal ataxia (HP:0002078)2.06094371
104Inability to walk (HP:0002540)2.03708176
105Asymmetric septal hypertrophy (HP:0001670)2.03000574
106Abnormality of the corticospinal tract (HP:0002492)2.01674663
107Deviation of the hallux (HP:0010051)1.99545347
108Elbow flexion contracture (HP:0002987)1.98494619
109Amblyopia (HP:0000646)1.97108682
110Protruding tongue (HP:0010808)1.96925666
111Excessive salivation (HP:0003781)1.96912837
112Status epilepticus (HP:0002133)1.96216291
113Striae distensae (HP:0001065)1.95561294
114Distal lower limb amyotrophy (HP:0008944)1.95274026
115Bowed forearm bones (HP:0003956)1.94118686
116Bowing of the arm (HP:0006488)1.94118686
117Round ear (HP:0100830)1.93201798
118Papilledema (HP:0001085)1.92793787
119Hand muscle atrophy (HP:0009130)1.91757955
120Cerebral hypomyelination (HP:0006808)1.91595962
121Buphthalmos (HP:0000557)1.91233881
122Absent speech (HP:0001344)1.91220429
123Joint laxity (HP:0001388)1.90179886
124Hallux valgus (HP:0001822)1.89671839
125Bronchomalacia (HP:0002780)1.88231430
126Narrow nasal bridge (HP:0000446)1.87538078
127Facial diplegia (HP:0001349)1.87299140
128Ectopia lentis (HP:0001083)1.87144660
129Broad-based gait (HP:0002136)1.86420928
130Mitral stenosis (HP:0001718)1.85171946
131Right ventricular cardiomyopathy (HP:0011663)1.85105305
132Cerebral inclusion bodies (HP:0100314)1.84886979
133Increased corneal curvature (HP:0100692)1.84388560
134Keratoconus (HP:0000563)1.84388560
135Tarsal synostosis (HP:0008368)1.84204074
136CNS hypomyelination (HP:0003429)1.83811419
137Camptodactyly of toe (HP:0001836)1.82736803
138Genital tract atresia (HP:0001827)1.81909764
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80041234
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.80041234
141Short nail (HP:0001799)1.79243095
142Aplasia/Hypoplasia of the lens (HP:0008063)1.77973373
143Difficulty running (HP:0009046)1.77846845
144Osteolytic defects of the hand bones (HP:0009699)1.77331046
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.77331046
146Retinal dysplasia (HP:0007973)1.77238036
147Visual hallucinations (HP:0002367)1.76810241
148Poor eye contact (HP:0000817)1.76621894
149Hemiplegia (HP:0002301)1.74346780
150Depression (HP:0000716)1.73661593
151Abnormality of midbrain morphology (HP:0002418)1.73047768
152Molar tooth sign on MRI (HP:0002419)1.73047768
153Hypoplasia of the iris (HP:0007676)1.72905790
154Bulbous nose (HP:0000414)1.72431197
155Vaginal atresia (HP:0000148)1.71893350
156Tubulointerstitial nephritis (HP:0001970)1.71193791
157Short foot (HP:0001773)1.71069364
158Megalencephaly (HP:0001355)1.70920333
159Muscle fiber splitting (HP:0003555)1.69492449
160Absent frontal sinuses (HP:0002688)1.68224809
161Urinary urgency (HP:0000012)1.68097830
162Bell-shaped thorax (HP:0001591)1.67693334
163Synostosis involving bones of the lower limbs (HP:0009138)1.67202958
164Synostosis involving bones of the feet (HP:0009140)1.67202958
165Ulnar claw (HP:0001178)1.65464074
166Short hallux (HP:0010109)1.65112416
167Skin nodule (HP:0200036)1.64740347
168Neurofibrillary tangles (HP:0002185)1.64345689
169Sleep apnea (HP:0010535)1.64193900
170Congenital glaucoma (HP:0001087)1.62555192
171Decreased central vision (HP:0007663)1.61466575
172Enlarged penis (HP:0000040)1.61213795
173Mesomelia (HP:0003027)1.61078787
174Tibial bowing (HP:0002982)1.59970443
175Disproportionate tall stature (HP:0001519)1.59859319
176Flat cornea (HP:0007720)1.57977690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.21370751
2TTN3.63974408
3FRK3.36945962
4DDR23.18849217
5PDGFRA3.09283519
6PKN22.99943151
7LATS22.87133029
8LMTK22.57561501
9SIK12.32962260
10CASK2.21496417
11MST1R2.18045799
12BMX2.10760559
13ERN11.97406040
14INSRR1.93306702
15NTRK31.90925281
16RIPK11.88470760
17GRK11.86600226
18EPHA41.80910503
19MAPK131.79664284
20PRKD31.70872034
21NTRK11.70043554
22MET1.69445460
23PAK61.66049894
24LATS11.63165923
25MAP2K71.62446337
26PHKG21.61610004
27PHKG11.61610004
28EPHB21.56631721
29GRK51.53478624
30PINK11.52073186
31PAK31.51129767
32CAMKK11.42834437
33TAOK11.40113466
34MAP3K61.36600850
35MAP3K91.36496362
36ADRBK21.27695705
37PTK21.24881199
38PAK21.23984438
39DMPK1.22395341
40PRKCH1.20896033
41TNIK1.20706719
42UHMK11.20096909
43ARAF1.18896667
44CSNK1G21.11124401
45PTK2B1.10807458
46STK381.08593608
47RET1.08528732
48PTK61.06886562
49ADRBK11.06073063
50CAMK11.05898963
51KSR20.99791747
52PDGFRB0.98451150
53PRKCE0.97486022
54TRIM280.97098788
55TYRO30.95152601
56CSNK1A1L0.93912012
57CAMK2A0.91919786
58MINK10.90901895
59ROCK10.90471955
60FER0.86833079
61MAP3K100.86174371
62FGFR10.85734612
63CAMK2B0.84369517
64SGK2230.84078829
65SGK4940.84078829
66STK38L0.83337559
67MARK10.83193705
68DYRK20.82242328
69LIMK10.82137890
70TGFBR20.82118699
71CSNK1G10.81157660
72PRKD20.79715219
73DYRK1A0.79265473
74MOS0.79191683
75CDC42BPA0.78598361
76EPHA30.77711502
77TIE10.77478227
78DAPK20.77355632
79PIK3CG0.76810459
80MAP3K20.75813488
81PKN10.75627300
82CSNK1G30.75443451
83RAF10.74419546
84EEF2K0.74367977
85WNK30.73238842
86KSR10.72656329
87MTOR0.71993279
88MAP3K70.71506634
89MAP2K10.71144135
90PLK20.70124694
91SGK20.69879507
92BMPR1B0.69471436
93NEK10.69162391
94NTRK20.66849765
95BCR0.66026816
96CAMK1D0.65141279
97ICK0.64760449
98CDK50.64628955
99PRKD10.61687668
100MAP2K40.61469145
101SIK20.61424986
102PIM20.61281733
103FGFR20.60623733
104CDK190.60594987
105ILK0.60308958
106CAMK1G0.60251604
107ROCK20.60078866
108PAK40.59364858
109MAPK120.58654166
110CDK150.58311418
111STK110.57960496
112CAMK2G0.57789651
113ALK0.57629686
114LRRK20.56200563
115TNK20.54941792
116CAMKK20.54138984
117MYLK0.53167091
118OXSR10.51774819
119CDK180.51641223
120SRC0.51144083
121PIK3CA0.49778121
122TRPM70.49413772
123STK240.48589351
124SGK30.47822385
125PRKG20.46576063
126SGK10.45493192
127ERBB40.44648670
128PRKCZ0.44379077
129CSNK1D0.43975856
130CDK11A0.43883617
131NUAK10.43845894
132MAPK70.43686983
133CDK140.43427082
134PDPK10.43286372
135AKT20.43187298
136RPS6KA30.42622864
137INSR0.42575867
138MAP3K40.42286820
139ERBB30.42215013
140TAOK20.41933230
141FES0.41429637
142DAPK10.40411313
143PRKG10.40219056
144PRKCG0.39875661
145MARK20.39762999
146STK30.39370841
147SCYL20.39289974
148DAPK30.37118374
149ERBB20.36952538

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.12425492
2ECM-receptor interaction_Homo sapiens_hsa045122.24248718
3Primary bile acid biosynthesis_Homo sapiens_hsa001201.96327737
4Long-term potentiation_Homo sapiens_hsa047201.93840193
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89790764
6Dilated cardiomyopathy_Homo sapiens_hsa054141.78618818
7Focal adhesion_Homo sapiens_hsa045101.70821186
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62647057
9Long-term depression_Homo sapiens_hsa047301.59343919
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58821927
11Calcium signaling pathway_Homo sapiens_hsa040201.56667076
12Phototransduction_Homo sapiens_hsa047441.56278747
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55902296
14Taste transduction_Homo sapiens_hsa047421.53909795
15Arginine biosynthesis_Homo sapiens_hsa002201.53487922
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53138464
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43354114
18Serotonergic synapse_Homo sapiens_hsa047261.43228441
19Complement and coagulation cascades_Homo sapiens_hsa046101.42280549
20cAMP signaling pathway_Homo sapiens_hsa040241.38271209
21Caffeine metabolism_Homo sapiens_hsa002321.37566484
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33822490
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31125271
24Fatty acid degradation_Homo sapiens_hsa000711.29872367
25Proteoglycans in cancer_Homo sapiens_hsa052051.29583665
26Fatty acid metabolism_Homo sapiens_hsa012121.29382677
27Bile secretion_Homo sapiens_hsa049761.23753097
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.21770567
29PPAR signaling pathway_Homo sapiens_hsa033201.21519712
30Fatty acid biosynthesis_Homo sapiens_hsa000611.17260281
31Amoebiasis_Homo sapiens_hsa051461.17006147
32Dorso-ventral axis formation_Homo sapiens_hsa043201.15537473
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15501872
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09968754
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07788492
36Axon guidance_Homo sapiens_hsa043601.05969813
37GABAergic synapse_Homo sapiens_hsa047271.04652755
38Glioma_Homo sapiens_hsa052141.03864063
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03064608
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02964028
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02686415
42Melanogenesis_Homo sapiens_hsa049161.01616305
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00595718
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00511873
45Butanoate metabolism_Homo sapiens_hsa006500.99414495
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.98494964
47Vitamin B6 metabolism_Homo sapiens_hsa007500.98156100
48Protein digestion and absorption_Homo sapiens_hsa049740.97516479
49Circadian entrainment_Homo sapiens_hsa047130.95003077
50Gap junction_Homo sapiens_hsa045400.94714255
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93389639
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92274940
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91320405
54Synaptic vesicle cycle_Homo sapiens_hsa047210.90879249
55Salivary secretion_Homo sapiens_hsa049700.89786900
56GnRH signaling pathway_Homo sapiens_hsa049120.89724434
57Collecting duct acid secretion_Homo sapiens_hsa049660.88868083
58Starch and sucrose metabolism_Homo sapiens_hsa005000.88296791
59Bladder cancer_Homo sapiens_hsa052190.87017960
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85658872
61Gastric acid secretion_Homo sapiens_hsa049710.85423539
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84636276
63Estrogen signaling pathway_Homo sapiens_hsa049150.84118634
64Ras signaling pathway_Homo sapiens_hsa040140.82261315
65Biosynthesis of amino acids_Homo sapiens_hsa012300.81892704
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81492415
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80110552
68Glutamatergic synapse_Homo sapiens_hsa047240.79907871
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79013819
70Cocaine addiction_Homo sapiens_hsa050300.78923541
71Nicotine addiction_Homo sapiens_hsa050330.78490981
72Basal cell carcinoma_Homo sapiens_hsa052170.78201446
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78170776
74Ovarian steroidogenesis_Homo sapiens_hsa049130.77438441
75Oxytocin signaling pathway_Homo sapiens_hsa049210.77259708
76Hippo signaling pathway_Homo sapiens_hsa043900.75712323
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74533004
78Rap1 signaling pathway_Homo sapiens_hsa040150.74328141
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73993655
80Pancreatic secretion_Homo sapiens_hsa049720.73556878
81Prion diseases_Homo sapiens_hsa050200.72111822
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70114910
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69901928
84Olfactory transduction_Homo sapiens_hsa047400.69682850
85Adherens junction_Homo sapiens_hsa045200.68415582
86Cholinergic synapse_Homo sapiens_hsa047250.68223830
87Glucagon signaling pathway_Homo sapiens_hsa049220.67931662
88Malaria_Homo sapiens_hsa051440.67843740
89Tryptophan metabolism_Homo sapiens_hsa003800.67736831
90Thyroid hormone synthesis_Homo sapiens_hsa049180.67734100
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66181354
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.66008311
93Inositol phosphate metabolism_Homo sapiens_hsa005620.65801222
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65210113
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65014972
96Morphine addiction_Homo sapiens_hsa050320.64878524
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.64811075
98Propanoate metabolism_Homo sapiens_hsa006400.64371028
99Insulin secretion_Homo sapiens_hsa049110.64151465
100Type II diabetes mellitus_Homo sapiens_hsa049300.64024556
101Melanoma_Homo sapiens_hsa052180.62525905
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.61953909
103Circadian rhythm_Homo sapiens_hsa047100.61539931
104Carbon metabolism_Homo sapiens_hsa012000.61215816
105Dopaminergic synapse_Homo sapiens_hsa047280.60678389
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60184242
107Insulin signaling pathway_Homo sapiens_hsa049100.59072721
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58867498
109Lysine degradation_Homo sapiens_hsa003100.57021569
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.56936452
111MicroRNAs in cancer_Homo sapiens_hsa052060.56261441
112Arginine and proline metabolism_Homo sapiens_hsa003300.55629129
113Hedgehog signaling pathway_Homo sapiens_hsa043400.55545796
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55441391
115Chronic myeloid leukemia_Homo sapiens_hsa052200.55265044
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55109338
117MAPK signaling pathway_Homo sapiens_hsa040100.54794506
118ErbB signaling pathway_Homo sapiens_hsa040120.54566415
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.54465831
120Insulin resistance_Homo sapiens_hsa049310.53718108
121Oocyte meiosis_Homo sapiens_hsa041140.53485791
122Amphetamine addiction_Homo sapiens_hsa050310.53262377
123Renin secretion_Homo sapiens_hsa049240.53262274
124Lysosome_Homo sapiens_hsa041420.51888373
125AMPK signaling pathway_Homo sapiens_hsa041520.51160725
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50813991
127Vibrio cholerae infection_Homo sapiens_hsa051100.49906254
128Renal cell carcinoma_Homo sapiens_hsa052110.49818450
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49466275
130Choline metabolism in cancer_Homo sapiens_hsa052310.49138185
131Tight junction_Homo sapiens_hsa045300.47644181
132Sphingolipid metabolism_Homo sapiens_hsa006000.47183938
133Wnt signaling pathway_Homo sapiens_hsa043100.46239723
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.45410860
135Ether lipid metabolism_Homo sapiens_hsa005650.44915135
136Platelet activation_Homo sapiens_hsa046110.43695013
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43074094
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40762652
139Cardiac muscle contraction_Homo sapiens_hsa042600.40519144
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36944708
141VEGF signaling pathway_Homo sapiens_hsa043700.34008837

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