HHIPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.85740295
2oligosaccharide biosynthetic process (GO:0009312)8.47353670
3sperm motility (GO:0030317)7.94087485
4alpha-linolenic acid metabolic process (GO:0036109)7.32506046
5pattern specification involved in kidney development (GO:0061004)7.26053987
6fusion of sperm to egg plasma membrane (GO:0007342)7.03092171
7fatty-acyl-CoA biosynthetic process (GO:0046949)6.98841309
8chromosome condensation (GO:0030261)6.87837061
9acrosome reaction (GO:0007340)6.85843760
10long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.77655315
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.67833291
12sperm capacitation (GO:0048240)6.65318862
13acyl-CoA biosynthetic process (GO:0071616)6.61785173
14thioester biosynthetic process (GO:0035384)6.61785173
15DNA packaging (GO:0006323)6.60817779
16pyrimidine-containing compound transmembrane transport (GO:0072531)6.43476765
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.17032799
18linoleic acid metabolic process (GO:0043651)6.06377506
19positive regulation of p38MAPK cascade (GO:1900745)5.85128640
20response to pheromone (GO:0019236)5.77013439
21regulation of sequestering of triglyceride (GO:0010889)5.51426074
22lactation (GO:0007595)5.50180508
23glycoside metabolic process (GO:0016137)5.37832480
24sperm-egg recognition (GO:0035036)5.35548928
25spermatid development (GO:0007286)5.23148784
26fatty acid transmembrane transport (GO:1902001)5.16163876
27plasma membrane fusion (GO:0045026)5.14754792
28carnitine shuttle (GO:0006853)5.09600249
29long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.08481427
30thyroid hormone generation (GO:0006590)5.06648542
31binding of sperm to zona pellucida (GO:0007339)4.94511593
32microtubule depolymerization (GO:0007019)4.92721815
33fatty-acyl-CoA metabolic process (GO:0035337)4.92654038
34acetyl-CoA metabolic process (GO:0006084)4.90430217
35multicellular organism reproduction (GO:0032504)4.90428672
36nucleoside transmembrane transport (GO:1901642)4.89180499
37protein targeting to Golgi (GO:0000042)4.85818164
38regulation of centriole replication (GO:0046599)4.84090040
39negative regulation of fatty acid transport (GO:2000192)4.83450326
40mammary gland epithelial cell differentiation (GO:0060644)4.80519833
41ectoderm development (GO:0007398)4.78369054
42rRNA methylation (GO:0031167)4.77121058
43primary alcohol catabolic process (GO:0034310)4.75956473
44positive regulation of extracellular matrix organization (GO:1903055)4.74458685
45secretion by tissue (GO:0032941)4.69044671
46retrograde transport, vesicle recycling within Golgi (GO:0000301)4.66310662
47biotin metabolic process (GO:0006768)4.64754084
48single strand break repair (GO:0000012)4.63108631
49reproduction (GO:0000003)4.59725523
50spermatid nucleus differentiation (GO:0007289)4.57591622
51establishment of protein localization to Golgi (GO:0072600)4.49463321
52sexual reproduction (GO:0019953)4.49228110
53short-term memory (GO:0007614)4.39530384
54cell-cell recognition (GO:0009988)4.26061509
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.23671607
56carnitine transmembrane transport (GO:1902603)4.23595684
57nuclear pore complex assembly (GO:0051292)4.22506453
58protein polyglutamylation (GO:0018095)4.16565661
59folic acid transport (GO:0015884)4.15332327
60triglyceride biosynthetic process (GO:0019432)4.14175513
61spermatogenesis (GO:0007283)4.11327777
62male gamete generation (GO:0048232)4.10151069
63COPI coating of Golgi vesicle (GO:0048205)4.06788671
64Golgi transport vesicle coating (GO:0048200)4.06788671
65rRNA modification (GO:0000154)4.04494633
66nucleobase catabolic process (GO:0046113)4.04473672
67iron ion import (GO:0097286)4.03179599
68neutral lipid biosynthetic process (GO:0046460)3.99237816
69acylglycerol biosynthetic process (GO:0046463)3.99237816
70regulation of p38MAPK cascade (GO:1900744)3.99103332
71body fluid secretion (GO:0007589)3.97840494
72amino-acid betaine transport (GO:0015838)3.93732131
73carnitine transport (GO:0015879)3.93732131
74progesterone metabolic process (GO:0042448)3.92258435
75type B pancreatic cell proliferation (GO:0044342)3.90095443
76tooth mineralization (GO:0034505)3.90001007
77phosphatidylethanolamine biosynthetic process (GO:0006646)3.88898878
78N-acetylneuraminate metabolic process (GO:0006054)3.84342878
79phagocytosis, recognition (GO:0006910)3.83269515
80protein hydroxylation (GO:0018126)3.81274324
81C21-steroid hormone metabolic process (GO:0008207)3.80478234
82microtubule polymerization or depolymerization (GO:0031109)3.79010106
83keratan sulfate catabolic process (GO:0042340)3.77816082
84intestinal cholesterol absorption (GO:0030299)3.76099138
85thyroid hormone metabolic process (GO:0042403)3.75254864
86musculoskeletal movement (GO:0050881)3.73732267
87multicellular organismal movement (GO:0050879)3.73732267
88segment specification (GO:0007379)3.73340343
89gamete generation (GO:0007276)3.73100426
90glycerol ether metabolic process (GO:0006662)3.72355765
91cell wall macromolecule catabolic process (GO:0016998)3.70587474
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69630381
93microtubule severing (GO:0051013)3.68979580
94single fertilization (GO:0007338)3.68070138
95low-density lipoprotein particle clearance (GO:0034383)3.63066091
96positive regulation of triglyceride metabolic process (GO:0090208)3.62175334
97cell wall macromolecule metabolic process (GO:0044036)3.61165843
98axonemal dynein complex assembly (GO:0070286)3.59624954
99regulation of triglyceride biosynthetic process (GO:0010866)3.57504590
100tRNA methylation (GO:0030488)3.56160216
101nucleoside transport (GO:0015858)3.55573708
102glomerular visceral epithelial cell development (GO:0072015)3.55155619
103embryonic process involved in female pregnancy (GO:0060136)3.54625079
104response to phenylpropanoid (GO:0080184)3.54029690
105coenzyme A biosynthetic process (GO:0015937)3.52652040
106chondrocyte development (GO:0002063)3.52398517
107regulation of triglyceride metabolic process (GO:0090207)3.50133543
108protein localization to Golgi apparatus (GO:0034067)3.48894553
1094-hydroxyproline metabolic process (GO:0019471)3.48301416
110phosphatidylethanolamine metabolic process (GO:0046337)3.45005010
111long-chain fatty acid transport (GO:0015909)3.43609884
112nuclear pore organization (GO:0006999)3.41261771
113cell aggregation (GO:0098743)3.40487996
114cartilage condensation (GO:0001502)3.40487996
115mitotic G1 DNA damage checkpoint (GO:0031571)3.40318254
116regulation of penile erection (GO:0060405)3.39872521
117regulation of triglyceride catabolic process (GO:0010896)3.37748512
118regulation of proton transport (GO:0010155)3.37651136
119fatty acid transport (GO:0015908)3.37444232
120ether metabolic process (GO:0018904)3.36285179
121thioester metabolic process (GO:0035383)3.35008725
122acyl-CoA metabolic process (GO:0006637)3.35008725
123positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.34978847
124motile cilium assembly (GO:0044458)3.34478092
125growth hormone receptor signaling pathway (GO:0060396)3.34396382
126retinal metabolic process (GO:0042574)3.33049524
127valine metabolic process (GO:0006573)3.31275452
128ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.30908114
129nucleoside bisphosphate biosynthetic process (GO:0033866)3.30908114
130purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.30908114
131COPII vesicle coating (GO:0048208)3.27215099
132glucose 6-phosphate metabolic process (GO:0051156)3.27039371
133regulation of apoptotic process involved in morphogenesis (GO:1902337)3.26287686
134glomerular epithelial cell development (GO:0072310)3.25671367
135negative regulation of gluconeogenesis (GO:0045721)3.25491326
136notochord development (GO:0030903)3.25024147
137G1 DNA damage checkpoint (GO:0044783)3.23364154
138regulation of Rab GTPase activity (GO:0032313)3.22871377
139positive regulation of Rab GTPase activity (GO:0032851)3.22871377
140nucleus organization (GO:0006997)3.22120346
141thyroid gland development (GO:0030878)3.21661590
142O-glycan processing (GO:0016266)3.19247704
143regulation of plasminogen activation (GO:0010755)3.18682346
144seminiferous tubule development (GO:0072520)3.18441120
145lipopolysaccharide biosynthetic process (GO:0009103)3.17713687
146peptidyl-proline hydroxylation (GO:0019511)3.16576095
147centriole replication (GO:0007099)3.14654762
148heme transport (GO:0015886)3.12477673
149fertilization (GO:0009566)3.12365246
150NADPH regeneration (GO:0006740)3.07959319
151calcium ion-dependent exocytosis (GO:0017156)3.07512288
152triglyceride metabolic process (GO:0006641)3.06713883
153urate metabolic process (GO:0046415)3.06640589
154multicellular organismal reproductive process (GO:0048609)3.06255583
155polyamine biosynthetic process (GO:0006596)3.06219164
156pore complex assembly (GO:0046931)3.04107077
157positive regulation of lipid storage (GO:0010884)3.03260551
158acylglycerol homeostasis (GO:0055090)3.01261403
159triglyceride homeostasis (GO:0070328)3.01261403
160regulation of extracellular matrix organization (GO:1903053)2.99415080
161copper ion transport (GO:0006825)2.98112123
162intracellular lipid transport (GO:0032365)2.94617816
163lipid storage (GO:0019915)2.93928433
164centriole assembly (GO:0098534)2.92832284
165transcytosis (GO:0045056)2.91509607
166germ cell development (GO:0007281)2.89208553
167regulation of cilium movement (GO:0003352)2.89077261
168acylglycerol metabolic process (GO:0006639)2.88917832
169zinc ion transport (GO:0006829)2.88044761
170galactose metabolic process (GO:0006012)2.87956867
171negative regulation of inclusion body assembly (GO:0090084)2.86854435
172neutral lipid metabolic process (GO:0006638)2.84614426
173folic acid metabolic process (GO:0046655)2.84450545
174pentose metabolic process (GO:0019321)2.84104290
175cellular response to growth hormone stimulus (GO:0071378)2.83611521
176membrane protein ectodomain proteolysis (GO:0006509)2.81994795
177positive regulation of triglyceride biosynthetic process (GO:0010867)2.81966090
178protein retention in ER lumen (GO:0006621)2.81622236
179peptide catabolic process (GO:0043171)2.81242744
180pentose-phosphate shunt (GO:0006098)2.80977564
181positive regulation of triglyceride lipase activity (GO:0061365)2.80005412
182positive regulation of lipoprotein lipase activity (GO:0051006)2.80005412
183regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.79031680
184cellular process involved in reproduction in multicellular organism (GO:0022412)2.77396332
185mitotic G1/S transition checkpoint (GO:0044819)2.76380228
186DNA conformation change (GO:0071103)2.74001018
187sulfate transmembrane transport (GO:1902358)2.73065618
188RNA methylation (GO:0001510)2.73060795
189membrane protein intracellular domain proteolysis (GO:0031293)2.72544174
190muscle cell fate commitment (GO:0042693)2.71138853
191regulation of transcription involved in cell fate commitment (GO:0060850)2.67211831
192Golgi to endosome transport (GO:0006895)2.66827450
193daunorubicin metabolic process (GO:0044597)10.8987456
194polyketide metabolic process (GO:0030638)10.8987456
195doxorubicin metabolic process (GO:0044598)10.8987456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse5.88353485
2ESR1_21235772_ChIP-Seq_MCF-7_Human5.21559824
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16146557
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.60163922
5ESR2_21235772_ChIP-Seq_MCF-7_Human4.39121944
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25983954
7ZNF263_19887448_ChIP-Seq_K562_Human4.00909364
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.76072991
9AR_21572438_ChIP-Seq_LNCaP_Human3.57500670
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.54357959
11TRIM28_21343339_ChIP-Seq_HEK293_Human3.41250921
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.31507196
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.21933155
14LXR_22158963_ChIP-Seq_LIVER_Mouse3.08119668
15CLOCK_20551151_ChIP-Seq_293T_Human3.04014455
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78892313
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74168432
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.48535414
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46125523
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40155138
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34809930
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34142349
23ARNT_22903824_ChIP-Seq_MCF-7_Human2.24640108
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22306232
25JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04825191
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.95588784
27JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79254202
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79002902
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75117360
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73878326
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72101049
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68378105
33SMC4_20622854_ChIP-Seq_HELA_Human1.66556872
34GATA6_25053715_ChIP-Seq_YYC3_Human1.66334936
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62898278
36RXR_22108803_ChIP-Seq_LS180_Human1.56666757
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56660962
38CBP_20019798_ChIP-Seq_JUKART_Human1.56660962
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53052126
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44561155
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42738428
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41936361
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.41673001
44RAC3_21632823_ChIP-Seq_H3396_Human1.40034198
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38598836
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37683572
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37343142
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35798221
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.35292940
50SOX2_20726797_ChIP-Seq_SW620_Human1.34457230
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33485137
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33485137
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33206995
54TP63_22573176_ChIP-Seq_HFKS_Human1.32240196
55* BRD4_25478319_ChIP-Seq_HGPS_Human1.31762182
56FUS_26573619_Chip-Seq_HEK293_Human1.30724112
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30477682
58ERA_21632823_ChIP-Seq_H3396_Human1.30275122
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28698268
60GATA1_22025678_ChIP-Seq_K562_Human1.28477144
61RACK7_27058665_Chip-Seq_MCF-7_Human1.27974812
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27451073
63ER_23166858_ChIP-Seq_MCF-7_Human1.26268030
64AR_21909140_ChIP-Seq_LNCAP_Human1.26237336
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25537495
66TP53_22127205_ChIP-Seq_IMR90_Human1.24249500
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23835454
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22322499
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.22177813
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.22177813
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21212351
72E2F1_20622854_ChIP-Seq_HELA_Human1.21122104
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20758247
74GATA4_25053715_ChIP-Seq_YYC3_Human1.19303108
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.17808589
76ERG_20517297_ChIP-Seq_VCAP_Human1.17560595
77BCOR_27268052_Chip-Seq_Bcells_Human1.17220606
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17007214
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15254697
80CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15097978
81CEBPB_22108803_ChIP-Seq_LS180_Human1.14725076
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12474101
83P68_20966046_ChIP-Seq_HELA_Human1.11052981
84ELF5_23300383_ChIP-Seq_T47D_Human1.10861679
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10347587
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09683437
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09459439
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08726183
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08357634
90* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08060677
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.06937407
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06490408
93TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06051671
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05666117
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.05253543
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.04799696
97* RBPJ_21746931_ChIP-Seq_IB4_Human1.04393733
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.03885142
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03306727
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.02285723
101ATF3_27146783_Chip-Seq_COLON_Human1.02112718
102LXR_22292898_ChIP-Seq_THP-1_Human1.01553867
103CTCF_20526341_ChIP-Seq_ESCs_Human1.00200484
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98977984
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.98851522
106* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98356766
107PHF8_20622854_ChIP-Seq_HELA_Human0.97602426
108OCT4_20526341_ChIP-Seq_ESCs_Human0.96952651
109TP53_18474530_ChIP-ChIP_U2OS_Human0.96553856
110NANOG_20526341_ChIP-Seq_ESCs_Human0.95918807
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95610651
112FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94927827
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94455646
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.94413209
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.94161615
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93556362
117KLF5_25053715_ChIP-Seq_YYC3_Human0.93302898
118BCL6_27268052_Chip-Seq_Bcells_Human0.93146491
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92737612
120* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92282118
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91493586
122* CJUN_26792858_Chip-Seq_BT549_Human0.91346542
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91036593
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90644873
125CREB1_26743006_Chip-Seq_LNCaP_Human0.88014030
126KDM2B_26808549_Chip-Seq_K562_Human0.87738419
127P53_21459846_ChIP-Seq_SAOS-2_Human0.87135542
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.84932958
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83697061
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83024432
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82954348
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79059808
133GATA2_19941826_ChIP-Seq_K562_Human0.78133078
134* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76042812
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74841478
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74403160
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73470397
138TCF4_22108803_ChIP-Seq_LS180_Human0.73315104
139AHR_22903824_ChIP-Seq_MCF-7_Human0.71708364
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.69977855
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.69944175
142CBP_21632823_ChIP-Seq_H3396_Human0.69877091
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.69787076
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.69298338
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68911201
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68895444
147TP63_23658742_ChIP-Seq_EP156T_Human0.68834773
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68650235
149CSB_26484114_Chip-Seq_FIBROBLAST_Human0.68596015
150GATA1_19941826_ChIP-Seq_K562_Human0.67316509
151ZFP281_27345836_Chip-Seq_ESCs_Mouse0.66649170
152VDR_24787735_ChIP-Seq_THP-1_Human0.66149892
153* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66085239
154JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.65404301
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.65401178
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.64853072
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64484163
158SMC1_22415368_ChIP-Seq_MEFs_Mouse0.64135898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.85119817
2MP0005451_abnormal_body_composition3.57119673
3MP0003878_abnormal_ear_physiology3.27473640
4MP0005377_hearing/vestibular/ear_phenot3.27473640
5MP0002282_abnormal_trachea_morphology3.25207639
6MP0000627_abnormal_mammary_gland3.15908634
7MP0000681_abnormal_thyroid_gland3.10451400
8MP0002254_reproductive_system_inflammat3.08266560
9MP0005360_urolithiasis3.04858851
10MP0005083_abnormal_biliary_tract3.00513620
11MP0001348_abnormal_lacrimal_gland2.92219658
12MP0003705_abnormal_hypodermis_morpholog2.87579211
13MP0003698_abnormal_male_reproductive2.85285193
14MP0002139_abnormal_hepatobiliary_system2.77958903
15MP0003303_peritoneal_inflammation2.65335612
16MP0001929_abnormal_gametogenesis2.64010528
17MP0008875_abnormal_xenobiotic_pharmacok2.55521023
18MP0003300_gastrointestinal_ulcer2.53649401
19MP0005085_abnormal_gallbladder_physiolo2.46788776
20MP0004130_abnormal_muscle_cell2.42690142
21MP0004233_abnormal_muscle_weight2.36130541
22MP0004019_abnormal_vitamin_homeostasis2.17874193
23MP0002933_joint_inflammation2.07709481
24MP0003950_abnormal_plasma_membrane2.03207171
25MP0000678_abnormal_parathyroid_gland2.01247562
26MP0001881_abnormal_mammary_gland10.6229786
27MP0003011_delayed_dark_adaptation1.97117965
28MP0003718_maternal_effect1.89525612
29MP0003136_yellow_coat_color1.88348225
30MP0005670_abnormal_white_adipose1.88244145
31MP0001873_stomach_inflammation1.81001477
32MP0004134_abnormal_chest_morphology1.73026686
33MP0002161_abnormal_fertility/fecundity1.71014486
34MP0002909_abnormal_adrenal_gland1.70707844
35MP0008004_abnormal_stomach_pH1.68492246
36MP0001270_distended_abdomen1.60436330
37MP0004782_abnormal_surfactant_physiolog1.56483417
38MP0010329_abnormal_lipoprotein_level1.55610683
39MP0002796_impaired_skin_barrier1.52973182
40MP0002249_abnormal_larynx_morphology1.52944820
41MP0000534_abnormal_ureter_morphology1.50458753
42MP0004272_abnormal_basement_membrane1.48100161
43MP0005503_abnormal_tendon_morphology1.47290266
44MP0003123_paternal_imprinting1.47009481
45MP0003077_abnormal_cell_cycle1.46347376
46MP0003091_abnormal_cell_migration1.42649692
47MP0010368_abnormal_lymphatic_system1.42419780
48MP0002896_abnormal_bone_mineralization1.40963668
49MP0002118_abnormal_lipid_homeostasis1.40458261
50MP0005408_hypopigmentation1.40134169
51MP0000163_abnormal_cartilage_morphology1.39952927
52MP0002098_abnormal_vibrissa_morphology1.38570354
53MP0004147_increased_porphyrin_level1.38310049
54MP0004264_abnormal_extraembryonic_tissu1.38300018
55MP0009053_abnormal_anal_canal1.36090470
56MP0005666_abnormal_adipose_tissue1.33784765
57MP0000377_abnormal_hair_follicle1.33411255
58MP0001666_abnormal_nutrient_absorption1.32949073
59MP0002876_abnormal_thyroid_physiology1.31042555
60MP0005395_other_phenotype1.26145758
61MP0000383_abnormal_hair_follicle1.24808197
62MP0001485_abnormal_pinna_reflex1.24153837
63MP0003656_abnormal_erythrocyte_physiolo1.22548412
64MP0001663_abnormal_digestive_system1.18896411
65MP0002210_abnormal_sex_determination1.18856641
66MP0003566_abnormal_cell_adhesion1.18421906
67MP0000733_abnormal_muscle_development1.17792008
68MP0000762_abnormal_tongue_morphology1.16677468
69MP0000639_abnormal_adrenal_gland1.13769139
70MP0003646_muscle_fatigue1.12628486
71MP0008438_abnormal_cutaneous_collagen1.09516915
72MP0005410_abnormal_fertilization1.08139685
73MP0003806_abnormal_nucleotide_metabolis1.07525818
74MP0003936_abnormal_reproductive_system1.07155252
75MP0005375_adipose_tissue_phenotype1.07147366
76MP0010307_abnormal_tumor_latency1.07088364
77MP0002108_abnormal_muscle_morphology1.04380722
78MP0010678_abnormal_skin_adnexa1.03362548
79MP0001664_abnormal_digestion1.02744629
80MP0001145_abnormal_male_reproductive1.01675808
81MP0000467_abnormal_esophagus_morphology1.01509412
82MP0005275_abnormal_skin_tensile1.01425725
83MP0000750_abnormal_muscle_regeneration1.00675748
84MP0005381_digestive/alimentary_phenotyp1.00374643
85MP0003252_abnormal_bile_duct0.99952178
86MP0002115_abnormal_skeleton_extremities0.99614988
87MP0004084_abnormal_cardiac_muscle0.98760521
88MP0000427_abnormal_hair_cycle0.97694419
89MP0009384_cardiac_valve_regurgitation0.97212854
90MP0005623_abnormal_meninges_morphology0.97208136
91MP0002089_abnormal_postnatal_growth/wei0.96567515
92MP0004185_abnormal_adipocyte_glucose0.95951236
93MP0003115_abnormal_respiratory_system0.95015582
94MP0001849_ear_inflammation0.94663675
95MP0000609_abnormal_liver_physiology0.92868831
96MP0005365_abnormal_bile_salt0.92792167
97MP0000653_abnormal_sex_gland0.91835605
98MP0003959_abnormal_lean_body0.90403734
99MP0005332_abnormal_amino_acid0.89986706
100MP0005023_abnormal_wound_healing0.89927887
101MP0005076_abnormal_cell_differentiation0.87804218
102MP0005248_abnormal_Harderian_gland0.85370404
103MP0005334_abnormal_fat_pad0.84037354
104MP0002113_abnormal_skeleton_development0.84010891
105MP0004957_abnormal_blastocyst_morpholog0.83540459
106MP0008932_abnormal_embryonic_tissue0.82530924
107MP0001533_abnormal_skeleton_physiology0.82439107
108MP0004742_abnormal_vestibular_system0.82408487
109MP0001879_abnormal_lymphatic_vessel0.81068095
110MP0009780_abnormal_chondrocyte_physiolo0.80055296
111MP0010352_gastrointestinal_tract_polyps0.79296865
112MP0002970_abnormal_white_adipose0.79184282
113MP0001765_abnormal_ion_homeostasis0.78982244
114MP0009250_abnormal_appendicular_skeleto0.78198993
115MP0003755_abnormal_palate_morphology0.77466320
116MP0003935_abnormal_craniofacial_develop0.77246582
117MP0008770_decreased_survivor_rate0.76846135
118MP0002168_other_aberrant_phenotype0.76291134
119MP0002971_abnormal_brown_adipose0.76256606
120MP0005165_increased_susceptibility_to0.75106217
121MP0005584_abnormal_enzyme/coenzyme_acti0.73539896
122MP0003795_abnormal_bone_structure0.72684931
123MP0000751_myopathy0.70845341
124MP0005501_abnormal_skin_physiology0.70753671
125MP0008057_abnormal_DNA_replication0.70687171
126MP0003045_fibrosis0.70245717
127MP0003448_altered_tumor_morphology0.69584021
128MP0002109_abnormal_limb_morphology0.68730301
129MP0005164_abnormal_response_to0.68400876
130MP0000003_abnormal_adipose_tissue0.68278369
131MP0000013_abnormal_adipose_tissue0.67683976
132MP0003638_abnormal_response/metabolism_0.67103353
133MP0001216_abnormal_epidermal_layer0.66900585
134MP0003943_abnormal_hepatobiliary_system0.66606560
135MP0002932_abnormal_joint_morphology0.64627038
136MP0002877_abnormal_melanocyte_morpholog0.64519034
137MP0005390_skeleton_phenotype0.63737034
138MP0005319_abnormal_enzyme/_coenzyme0.62443254
139MP0003195_calcinosis0.62424892
140MP0000343_altered_response_to0.61755690
141MP0000371_diluted_coat_color0.61460574
142MP0000049_abnormal_middle_ear0.60331800
143MP0002086_abnormal_extraembryonic_tissu0.59710293
144MP0000470_abnormal_stomach_morphology0.58829341
145MP0005084_abnormal_gallbladder_morpholo0.58606683
146MP0002396_abnormal_hematopoietic_system0.58481331
147MP0000432_abnormal_head_morphology0.57012292
148MP0002998_abnormal_bone_remodeling0.56166748
149MP0001177_atelectasis0.54344762
150MP0000490_abnormal_crypts_of0.52935080
151MP0005636_abnormal_mineral_homeostasis0.52744562
152MP0009115_abnormal_fat_cell0.51921404
153MP0000858_altered_metastatic_potential0.51717304
154MP0009840_abnormal_foam_cell0.51316207
155MP0002060_abnormal_skin_morphology0.50145740
156MP0005508_abnormal_skeleton_morphology0.49781917
157MP0009643_abnormal_urine_homeostasis0.49502964

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.06339538
2Irregular epiphyses (HP:0010582)6.67472629
3Vitreoretinal degeneration (HP:0000655)5.54401193
4Hypoplastic ischia (HP:0003175)4.99605625
5Abnormal tarsal ossification (HP:0008369)4.95996747
6Flat acetabular roof (HP:0003180)4.82896070
7Cupped ribs (HP:0000887)4.72085987
8Small epiphyses (HP:0010585)4.69738519
9Flat capital femoral epiphysis (HP:0003370)4.52178136
10Abnormality of the ischium (HP:0003174)4.42255645
11Cone-rod dystrophy (HP:0000548)4.39173701
12Genu varum (HP:0002970)4.29851839
13Delayed epiphyseal ossification (HP:0002663)4.26019697
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.24477445
15Tubulointerstitial nephritis (HP:0001970)4.13461342
16Protuberant abdomen (HP:0001538)4.04597258
17Asymmetric septal hypertrophy (HP:0001670)4.03295640
18Short nail (HP:0001799)3.99100481
19Attenuation of retinal blood vessels (HP:0007843)3.97188165
20Abnormal foot bone ossification (HP:0010675)3.68465208
21Amelogenesis imperfecta (HP:0000705)3.61329127
22Neonatal short-limb short stature (HP:0008921)3.54299484
23Goiter (HP:0000853)3.48705794
24Absent/shortened dynein arms (HP:0200106)3.46792592
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.46792592
26Hyperkalemia (HP:0002153)3.43246464
27Osteoarthritis (HP:0002758)3.43210363
28Severe visual impairment (HP:0001141)3.41372074
29Abnormality of purine metabolism (HP:0004352)3.37736391
30Metaphyseal dysplasia (HP:0100255)3.37633276
31Overgrowth (HP:0001548)3.27574847
32Conjugated hyperbilirubinemia (HP:0002908)3.26817800
33Flattened epiphyses (HP:0003071)3.23379016
34Abnormal vertebral ossification (HP:0100569)3.22074024
35Abnormality of the vertebral endplates (HP:0005106)3.20216457
36Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.19892300
37Abnormality of femoral epiphyses (HP:0006499)3.19892300
38Metaphyseal irregularity (HP:0003025)3.17676530
39Spinal cord compression (HP:0002176)3.11213353
40Renovascular hypertension (HP:0100817)3.09219362
41Gout (HP:0001997)3.05714957
42Menstrual irregularities (HP:0000858)3.02413469
43Abnormality of macular pigmentation (HP:0008002)3.02100292
44Hypoalphalipoproteinemia (HP:0003233)2.97923382
45Hypophosphatemic rickets (HP:0004912)2.95851849
46Premature rupture of membranes (HP:0001788)2.95585414
47Exostoses (HP:0100777)2.90171164
48Abnormality of the epiphysis of the femoral head (HP:0010574)2.89789840
49Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.89431348
50Absent epiphyses (HP:0010577)2.89431348
51Resting tremor (HP:0002322)2.85206141
52Bony spicule pigmentary retinopathy (HP:0007737)2.82299388
53Broad face (HP:0000283)2.81050853
54Bell-shaped thorax (HP:0001591)2.75141161
55Focal segmental glomerulosclerosis (HP:0000097)2.74601392
56Enlarged epiphyses (HP:0010580)2.74467889
57Stridor (HP:0010307)2.72907595
58Short femoral neck (HP:0100864)2.62315154
59Cervical subluxation (HP:0003308)2.60551437
60Glomerulosclerosis (HP:0000096)2.58710877
61Thoracolumbar scoliosis (HP:0002944)2.57708027
62Abnormality of carpal bone ossification (HP:0006257)2.56303766
63Barrel-shaped chest (HP:0001552)2.55014406
64Male infertility (HP:0003251)2.54291701
65Coxa vara (HP:0002812)2.54235810
66Arthropathy (HP:0003040)2.54071361
67Abnormality of the femoral head (HP:0003368)2.53030583
68Axonal loss (HP:0003447)2.50755281
69Thyroid-stimulating hormone excess (HP:0002925)2.47926922
70Abnormality of cochlea (HP:0000375)2.47074621
71Abnormality of the proximal phalanges of the hand (HP:0009834)2.46706879
72Carpal bone hypoplasia (HP:0001498)2.46432235
73Platyspondyly (HP:0000926)2.45474678
74Hypoplasia of the odontoid process (HP:0003311)2.44959364
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.44939219
76Osteolytic defects of the hand bones (HP:0009699)2.44939219
77Abnormality of the vitreous humor (HP:0004327)2.44253164
78Abnormality of dentin (HP:0010299)2.43871358
79Vertebral hypoplasia (HP:0008417)2.43164093
80Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.43164093
81Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.42670996
82Congenital sensorineural hearing impairment (HP:0008527)2.42351212
83Thin ribs (HP:0000883)2.42162512
84Abnormality of the acetabulum (HP:0003170)2.36889337
85Abnormal sex determination (HP:0012244)2.32714264
86Sex reversal (HP:0012245)2.32714264
87Abnormality of dental color (HP:0011073)2.31888587
88Glossoptosis (HP:0000162)2.31854269
89Limited hip movement (HP:0008800)2.31249531
90Chronic hepatic failure (HP:0100626)2.29261878
91Irregular vertebral endplates (HP:0003301)2.28023285
92Wormian bones (HP:0002645)2.25891480
93Ulnar deviation of the wrist (HP:0003049)2.23545271
94Abnormality of the lumbar spine (HP:0100712)2.21217106
95Unilateral renal agenesis (HP:0000122)2.21215454
96Ovoid vertebral bodies (HP:0003300)2.20950615
97Anterior segment dysgenesis (HP:0007700)2.19998572
98Rickets (HP:0002748)2.18917435
99Beaking of vertebral bodies (HP:0004568)2.18524669
100Stage 5 chronic kidney disease (HP:0003774)2.17771423
101Deep venous thrombosis (HP:0002625)2.16923359
102Prolonged neonatal jaundice (HP:0006579)2.16330242
103Metaphyseal cupping (HP:0003021)2.16184778
104Right ventricular cardiomyopathy (HP:0011663)2.15677966
105Congenital ichthyosiform erythroderma (HP:0007431)2.15159170
106Abnormal ciliary motility (HP:0012262)2.13411670
107Abnormality of the pubic bones (HP:0003172)2.12031969
108Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11918241
109Fibular hypoplasia (HP:0003038)2.11675807
110Back pain (HP:0003418)2.11527779
111Abdominal distention (HP:0003270)2.11425546
112Hip contracture (HP:0003273)2.09732924
113Vertebral clefting (HP:0008428)2.09168986
114Lumbar hyperlordosis (HP:0002938)2.08237465
115Ectopia lentis (HP:0001083)2.08026722
116Vertebral compression fractures (HP:0002953)2.06920513
117Abnormal rod and cone electroretinograms (HP:0008323)2.05836283
118Elfin facies (HP:0004428)2.05797765
119Mild short stature (HP:0003502)2.05662266
120Abnormal hand bone ossification (HP:0010660)2.05298338
121Cerebellar dysplasia (HP:0007033)2.03954172
122Abnormality of nucleobase metabolism (HP:0010932)2.03190769
123Hyperacusis (HP:0010780)2.02785958
124Abnormal ossification of hand bones (HP:0005921)2.02045614
125Aplasia/hypoplasia of the femur (HP:0005613)2.01337522
126Abnormality of the odontoid process (HP:0003310)1.99024746
127Abnormal respiratory motile cilium physiology (HP:0012261)1.98930968
128Cortical dysplasia (HP:0002539)1.97338435
129Hypolipoproteinemia (HP:0010981)1.97128284
130Aortic aneurysm (HP:0004942)1.96828082
131Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.95951238
132Mitral stenosis (HP:0001718)1.95587510
133Termporal pattern (HP:0011008)1.95249439
134Insidious onset (HP:0003587)1.95249439
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.94859190
136Abnormal cartilage morphology (HP:0002763)1.93393232
137Femoral bowing (HP:0002980)1.92824455
138Nasal polyposis (HP:0100582)1.92399412
139Spastic paraparesis (HP:0002313)1.91509169
140Limited elbow extension (HP:0001377)1.91024256
141Stillbirth (HP:0003826)1.89299198
142Spondylolisthesis (HP:0003302)1.86399103
143Abnormality of the 2nd finger (HP:0004100)1.86173548
144Cardiovascular calcification (HP:0011915)1.85535702
145Waddling gait (HP:0002515)1.84269641
146Xanthomatosis (HP:0000991)1.84239707
147Protrusio acetabuli (HP:0003179)1.80787254
148Infertility (HP:0000789)1.80055720
149Facial shape deformation (HP:0011334)1.79652944
150Potter facies (HP:0002009)1.79652944
151Pili torti (HP:0003777)1.78447401
152Relative macrocephaly (HP:0004482)1.77874725
153Abnormality of the nasal septum (HP:0000419)1.77845363
154Premature skin wrinkling (HP:0100678)1.77159528
155Impulsivity (HP:0100710)1.76739528
156Cranial hyperostosis (HP:0004437)1.76445481
157Vascular calcification (HP:0004934)1.75355475
158Autoamputation (HP:0001218)1.74642970
159Severe Myopia (HP:0011003)1.74484287
160Natal tooth (HP:0000695)1.74289087
161Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.73723145
162Thin bony cortex (HP:0002753)1.73449497
163Abnormal delivery (HP:0001787)1.72550340
164Nephritis (HP:0000123)1.72468139
165Tubulointerstitial abnormality (HP:0001969)1.72442137
166Abnormal respiratory motile cilium morphology (HP:0005938)1.71577022
167Abnormal respiratory epithelium morphology (HP:0012253)1.71577022
168Hyponatremia (HP:0002902)1.70764626
169Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.70570805
170Curly hair (HP:0002212)1.69674715
171Disproportionate short-trunk short stature (HP:0003521)1.69401890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK16.44684353
2PLK44.83682244
3PKN24.30731121
4CAMK1D3.91089793
5TRIB33.46047026
6MATK3.33491819
7MAP3K33.24765889
8PBK3.20555792
9CDK123.16080480
10CAMK1G3.11277370
11STK38L3.08991387
12PDK32.81455448
13PDK42.81455448
14INSRR2.71734125
15NME22.71628533
16LATS12.71410639
17EEF2K2.67312022
18DDR22.47226451
19ERN12.35883450
20NME12.28374017
21BRD42.13459833
22PNCK2.12607046
23EPHB12.11769158
24PDK22.11453659
25BCKDK1.99603532
26MOS1.94117568
27PTK61.85468947
28EPHA31.76827400
29IRAK31.70093654
30NEK61.45847764
31CASK1.45464039
32CDK71.45195189
33TLK11.36690613
34PDGFRB1.36465708
35RIPK11.33459562
36PIK3CA1.29112509
37MAPK151.15699268
38STK31.13170574
39PRKAA21.09329726
40CDK81.09222454
41RET1.09207256
42WNK41.05484679
43DAPK21.04270288
44ZAP701.03601483
45STK241.03193520
46EPHA21.01623553
47NEK10.97366782
48FER0.96505586
49BRSK20.96025216
50FGFR40.95392843
51MAP2K20.95073530
52TAOK10.94461271
53STK380.91946018
54STK390.89915200
55WNK10.89472030
56GSK3A0.84687250
57MAP3K90.82994214
58PHKG20.82409047
59PHKG10.82409047
60LRRK20.81647586
61MAPKAPK30.80620617
62MAP3K70.78780903
63BRSK10.77185936
64ERBB20.76427186
65MAP2K10.75459200
66BMX0.74891090
67NUAK10.74410590
68EIF2AK10.74349836
69MAPK120.70497050
70PRKAA10.70242906
71PTK20.61783225
72NTRK10.61749465
73LATS20.60306295
74RPS6KB20.59351042
75TGFBR20.57330575
76MTOR0.55880842
77CSF1R0.54651001
78MAP3K80.52732057
79MELK0.51688123
80AKT30.51043447
81MAPK40.49537240
82RPS6KA10.49509944
83PRKD30.49111474
84TESK10.48474488
85MAPK70.47631149
86FGFR10.47468182
87PTK2B0.47461849
88ICK0.45351095
89CDK10.45126885
90JAK10.44744694
91CHEK20.42783604
92PRKCZ0.42406690
93CDK20.41850721
94MST40.40588836
95MAPK140.40354879
96MAP4K20.39954281
97TRPM70.38953239
98FGFR30.37735306
99FRK0.36466106
100MAPK10.36271994
101MAP3K20.36061382
102MAPK110.35336599
103NLK0.35152794
104IGF1R0.33854745
105RPS6KL10.33771102
106RPS6KC10.33771102
107PDK10.33656028
108PDPK10.32914956
109RPS6KB10.32602809
110MET0.31251541
111GSK3B0.30845559
112EGFR0.30626236
113TTK0.29779167
114CDK40.29522497
115MST1R0.28096767
116JAK20.27785642
117PAK20.26396028
118ERBB30.25875006
119RPS6KA20.25248057
120PAK40.25147232
121MAPK100.24878225
122AURKA0.24603523
123CSNK1A10.24468636
124PRKG20.24365246
125RPS6KA60.23365977
126MUSK0.23142508
127CHEK10.22761193
128MAPK80.22442648
129CAMK10.21846343
130PDGFRA0.21187559
131CAMKK10.20789896
132PIM10.20559989
133PRKCI0.20341182
134AURKB0.20274133
135PRKD10.20163103
136SGK2230.19640172
137SGK4940.19640172
138DYRK1A0.19571730
139MAP3K60.18534002
140ROCK10.18418324
141MAP3K10.18330829
142AKT20.18174108
143NEK90.17759868
144PLK20.17059245
145CAMK2G0.16911242
146CDK60.16512153
147ILK0.16296497
148EIF2AK20.16095259
149PIK3CG0.15877363
150SGK30.15689112
151PRKACG0.15550600
152ERBB40.14517302
153ABL20.14140762
154LMTK20.14058646
155TTN0.13659717
156TSSK60.13554066
157FLT30.13518731

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.92678706
2Caffeine metabolism_Homo sapiens_hsa002327.30600932
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.71263888
4Galactose metabolism_Homo sapiens_hsa000523.28109408
5Fatty acid metabolism_Homo sapiens_hsa012122.82963902
6Thyroid hormone synthesis_Homo sapiens_hsa049182.70467786
7Propanoate metabolism_Homo sapiens_hsa006402.57518682
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54678110
9Pyruvate metabolism_Homo sapiens_hsa006202.46076706
10ABC transporters_Homo sapiens_hsa020102.41776110
11PPAR signaling pathway_Homo sapiens_hsa033202.08354938
12Glutathione metabolism_Homo sapiens_hsa004801.93836999
13Steroid biosynthesis_Homo sapiens_hsa001001.83239776
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.79283347
15Tyrosine metabolism_Homo sapiens_hsa003501.66967174
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63225921
17Prolactin signaling pathway_Homo sapiens_hsa049171.61785985
18Fatty acid degradation_Homo sapiens_hsa000711.56035623
19Non-homologous end-joining_Homo sapiens_hsa034501.42355725
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41665291
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39457374
22RNA transport_Homo sapiens_hsa030131.36840968
23Base excision repair_Homo sapiens_hsa034101.35112701
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33917181
25ECM-receptor interaction_Homo sapiens_hsa045121.33395928
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28055902
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27556330
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.26455941
29Olfactory transduction_Homo sapiens_hsa047401.16472540
30Vitamin B6 metabolism_Homo sapiens_hsa007501.16452349
31Carbon metabolism_Homo sapiens_hsa012001.11660004
32Sulfur relay system_Homo sapiens_hsa041221.10054493
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08967470
34Fatty acid elongation_Homo sapiens_hsa000621.07014870
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.06862087
36Sulfur metabolism_Homo sapiens_hsa009201.03055139
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99697837
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99184141
39Arginine biosynthesis_Homo sapiens_hsa002200.98893302
40Peroxisome_Homo sapiens_hsa041460.98127815
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97637440
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.97217554
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.96901543
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96188807
45Inositol phosphate metabolism_Homo sapiens_hsa005620.95753948
46Fat digestion and absorption_Homo sapiens_hsa049750.95707799
47Selenocompound metabolism_Homo sapiens_hsa004500.94505341
48Other glycan degradation_Homo sapiens_hsa005110.94079157
49Pentose phosphate pathway_Homo sapiens_hsa000300.93801591
50N-Glycan biosynthesis_Homo sapiens_hsa005100.92429519
51Biosynthesis of amino acids_Homo sapiens_hsa012300.91606767
52AMPK signaling pathway_Homo sapiens_hsa041520.90416301
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89307555
54Insulin resistance_Homo sapiens_hsa049310.87792990
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86958298
56Protein digestion and absorption_Homo sapiens_hsa049740.85199937
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.82914166
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82605395
59Butanoate metabolism_Homo sapiens_hsa006500.79753919
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78749103
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77110965
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74728246
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74359582
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74133510
65Sphingolipid metabolism_Homo sapiens_hsa006000.73451502
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73401330
67Glycerolipid metabolism_Homo sapiens_hsa005610.70691966
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.69721310
69Protein export_Homo sapiens_hsa030600.69067792
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67702675
71Mineral absorption_Homo sapiens_hsa049780.64914599
72Bladder cancer_Homo sapiens_hsa052190.64403949
73Glucagon signaling pathway_Homo sapiens_hsa049220.64188790
74Tryptophan metabolism_Homo sapiens_hsa003800.63234243
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61720618
76Retinol metabolism_Homo sapiens_hsa008300.61363593
77One carbon pool by folate_Homo sapiens_hsa006700.60164172
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58441877
79Focal adhesion_Homo sapiens_hsa045100.58376867
80Bile secretion_Homo sapiens_hsa049760.55933521
81Pancreatic cancer_Homo sapiens_hsa052120.55344373
82Arginine and proline metabolism_Homo sapiens_hsa003300.54609899
83Salivary secretion_Homo sapiens_hsa049700.53607616
84Starch and sucrose metabolism_Homo sapiens_hsa005000.53532778
85Endocytosis_Homo sapiens_hsa041440.52226801
86Hedgehog signaling pathway_Homo sapiens_hsa043400.52162750
87Small cell lung cancer_Homo sapiens_hsa052220.52050778
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51180718
89Folate biosynthesis_Homo sapiens_hsa007900.49692853
90Thyroid cancer_Homo sapiens_hsa052160.49213300
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48366358
92HIF-1 signaling pathway_Homo sapiens_hsa040660.47455299
93Insulin signaling pathway_Homo sapiens_hsa049100.47115567
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46973721
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.46749694
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46529995
97beta-Alanine metabolism_Homo sapiens_hsa004100.45828890
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45600624
99Lysine degradation_Homo sapiens_hsa003100.44738629
100Pyrimidine metabolism_Homo sapiens_hsa002400.44359446
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44143210
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43543655
103mTOR signaling pathway_Homo sapiens_hsa041500.43039194
104Complement and coagulation cascades_Homo sapiens_hsa046100.42995600
105Estrogen signaling pathway_Homo sapiens_hsa049150.41970530
106Purine metabolism_Homo sapiens_hsa002300.41529638
107Nitrogen metabolism_Homo sapiens_hsa009100.41215137
108Vibrio cholerae infection_Homo sapiens_hsa051100.41054786
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38797270
110Renin-angiotensin system_Homo sapiens_hsa046140.35942594
111Vitamin digestion and absorption_Homo sapiens_hsa049770.34660221
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34373255
113Adherens junction_Homo sapiens_hsa045200.34282230
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33914166
115Endometrial cancer_Homo sapiens_hsa052130.33873278
116Collecting duct acid secretion_Homo sapiens_hsa049660.32272087
117Circadian rhythm_Homo sapiens_hsa047100.31196090
118mRNA surveillance pathway_Homo sapiens_hsa030150.30902649
119Amoebiasis_Homo sapiens_hsa051460.30463083
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29226142
121MicroRNAs in cancer_Homo sapiens_hsa052060.28031555
122Dorso-ventral axis formation_Homo sapiens_hsa043200.26610396
123Proteoglycans in cancer_Homo sapiens_hsa052050.23841525
124Acute myeloid leukemia_Homo sapiens_hsa052210.21428840
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20369355
126Phagosome_Homo sapiens_hsa041450.20161671
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.19905454
128Renal cell carcinoma_Homo sapiens_hsa052110.19070822
129Fructose and mannose metabolism_Homo sapiens_hsa000510.18892711
130Metabolic pathways_Homo sapiens_hsa011000.18772179
131ErbB signaling pathway_Homo sapiens_hsa040120.18642483
132Chemical carcinogenesis_Homo sapiens_hsa052040.18614667
133Histidine metabolism_Homo sapiens_hsa003400.17400960
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17312884
135Malaria_Homo sapiens_hsa051440.14167351
136Hippo signaling pathway_Homo sapiens_hsa043900.13026314
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12759740
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12691972
139Phenylalanine metabolism_Homo sapiens_hsa003600.12589182
140TGF-beta signaling pathway_Homo sapiens_hsa043500.11714897
141Chronic myeloid leukemia_Homo sapiens_hsa052200.11452796
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09874770
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09772318

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