HHLA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of calcium ion-dependent exocytosis (GO:0045955)8.77355053
2regulation of posttranscriptional gene silencing (GO:0060147)7.51282363
3regulation of gene silencing by miRNA (GO:0060964)7.51282363
4regulation of gene silencing by RNA (GO:0060966)7.51282363
5superoxide anion generation (GO:0042554)6.57866550
6regulation of acrosome reaction (GO:0060046)6.50301453
7negative regulation of keratinocyte proliferation (GO:0010839)6.45938084
8pattern specification involved in kidney development (GO:0061004)6.40047706
9adenine nucleotide transport (GO:0051503)6.03409200
10purine ribonucleotide transport (GO:0015868)5.73948391
11negative regulation of telomerase activity (GO:0051974)5.57650922
12establishment of integrated proviral latency (GO:0075713)5.52591457
13pre-miRNA processing (GO:0031054)5.51464190
14purine nucleotide transport (GO:0015865)5.34477093
15opioid receptor signaling pathway (GO:0038003)4.79569259
16positive regulation of SMAD protein import into nucleus (GO:0060391)4.69375122
17heterochromatin organization (GO:0070828)4.62079625
18drug transmembrane transport (GO:0006855)4.57179524
19histone H2B ubiquitination (GO:0033523)4.55672253
20L-serine metabolic process (GO:0006563)4.51869612
21negative regulation of exocytosis (GO:0045920)4.43929106
22protein localization to kinetochore (GO:0034501)4.41876327
23protein complex localization (GO:0031503)4.40510640
24negative regulation of translation, ncRNA-mediated (GO:0040033)4.40430704
25regulation of translation, ncRNA-mediated (GO:0045974)4.40430704
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.40430704
27chromatin remodeling at centromere (GO:0031055)4.39413627
28regulation of histone H3-K9 methylation (GO:0051570)4.30314241
29IMP biosynthetic process (GO:0006188)4.29963000
30CENP-A containing nucleosome assembly (GO:0034080)4.26500832
31negative regulation of gene silencing (GO:0060969)4.21024985
32establishment of viral latency (GO:0019043)4.08682878
33DNA replication checkpoint (GO:0000076)4.05805138
34negative regulation of meiosis (GO:0045835)4.05690962
35regulation of cell fate specification (GO:0042659)4.02399071
36regulation of gene silencing (GO:0060968)4.00478213
37G-protein coupled receptor internalization (GO:0002031)4.00044979
38histone exchange (GO:0043486)3.98935770
39IMP metabolic process (GO:0046040)3.96637525
40regulation of mitotic spindle checkpoint (GO:1903504)3.95999794
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.95999794
42kinetochore assembly (GO:0051382)3.92912712
43righting reflex (GO:0060013)3.88427639
44DNA unwinding involved in DNA replication (GO:0006268)3.87088309
45mitotic metaphase plate congression (GO:0007080)3.83716907
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.82546797
47telomere maintenance via telomerase (GO:0007004)3.81334637
48DNA integration (GO:0015074)3.81025033
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.80223906
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.80223906
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.80223906
52negative regulation of sister chromatid segregation (GO:0033046)3.80223906
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.80223906
54negative regulation of chromosome segregation (GO:0051985)3.76979076
55DNA replication-independent nucleosome assembly (GO:0006336)3.76838404
56DNA replication-independent nucleosome organization (GO:0034724)3.76838404
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.70750366
58DNA strand elongation involved in DNA replication (GO:0006271)3.69904523
59negative regulation of reproductive process (GO:2000242)3.67978454
60purine nucleobase biosynthetic process (GO:0009113)3.66236496
61superoxide metabolic process (GO:0006801)3.62383932
62L-alpha-amino acid transmembrane transport (GO:1902475)3.60334648
63negative regulation of histone methylation (GO:0031061)3.59625561
64keratinocyte development (GO:0003334)3.57943684
65nucleobase biosynthetic process (GO:0046112)3.56866646
66regulation of chromatin silencing (GO:0031935)3.54277818
67paraxial mesoderm development (GO:0048339)3.53993651
68nuclear pore complex assembly (GO:0051292)3.53433604
69peripheral nervous system neuron development (GO:0048935)3.52533597
70DNA strand elongation (GO:0022616)3.50437013
71positive regulation of fibroblast migration (GO:0010763)3.46962981
72anterior/posterior axis specification, embryo (GO:0008595)3.45854230
73protein localization to chromosome, centromeric region (GO:0071459)3.44665981
74notochord development (GO:0030903)3.43786884
75homocysteine metabolic process (GO:0050667)3.42453642
76lysine metabolic process (GO:0006553)3.41322743
77lysine catabolic process (GO:0006554)3.41322743
78regulation of telomere maintenance via telomerase (GO:0032210)3.41238333
79histone arginine methylation (GO:0034969)3.36997342
80DNA replication-dependent nucleosome assembly (GO:0006335)3.36132231
81DNA replication-dependent nucleosome organization (GO:0034723)3.36132231
82mitotic spindle checkpoint (GO:0071174)3.34209958
83regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.33068041
84spindle checkpoint (GO:0031577)3.32932877
85lung-associated mesenchyme development (GO:0060484)3.32675325
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32045606
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32045606
88mitotic sister chromatid cohesion (GO:0007064)3.30905288
89negative regulation of androgen receptor signaling pathway (GO:0060766)3.29800602
90metanephric mesenchyme development (GO:0072075)3.29791448
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.29682652
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29682652
93reflex (GO:0060004)3.29481457
94nodal signaling pathway (GO:0038092)3.27956081
95regulation of mitotic sister chromatid separation (GO:0010965)3.27727022
96regulation of mitotic sister chromatid segregation (GO:0033047)3.27727022
97regulation of sister chromatid segregation (GO:0033045)3.27727022
98positive regulation of smooth muscle cell migration (GO:0014911)3.27431508
99regulation of SMAD protein import into nucleus (GO:0060390)3.26323619
100single strand break repair (GO:0000012)3.26109332
101cellular protein complex localization (GO:0034629)3.25914316
102nuclear pore organization (GO:0006999)3.25499239
103ATP-dependent chromatin remodeling (GO:0043044)3.24445561
104regulation of keratinocyte proliferation (GO:0010837)3.23583078
105regulation of DNA methylation (GO:0044030)3.21044275
106sulfate transport (GO:0008272)3.20467845
107mitotic spindle assembly checkpoint (GO:0007094)3.18477132
108ribosome assembly (GO:0042255)3.17568311
109regulation of chromosome segregation (GO:0051983)3.17350127
110cellular response to ATP (GO:0071318)3.17011729
111regulation of cell fate commitment (GO:0010453)3.15052609
112regulation of non-canonical Wnt signaling pathway (GO:2000050)3.15034855
113proximal/distal pattern formation (GO:0009954)3.14751033
114mitotic G2/M transition checkpoint (GO:0044818)3.13938179
115kidney mesenchyme development (GO:0072074)3.13403789
116long-chain fatty acid biosynthetic process (GO:0042759)3.13108820
117response to gravity (GO:0009629)3.12878013
118metaphase plate congression (GO:0051310)3.12151011
119spindle assembly checkpoint (GO:0071173)3.09329191
120telomere maintenance via semi-conservative replication (GO:0032201)3.08655753
121negative regulation of mitosis (GO:0045839)3.07600750
122regulation of activation of Janus kinase activity (GO:0010533)3.05604052
123behavioral response to ethanol (GO:0048149)3.04155301
124DNA replication initiation (GO:0006270)3.00898386
125positive regulation of chromosome segregation (GO:0051984)2.95713964
126regulation of stem cell maintenance (GO:2000036)2.94455622
127forebrain neuron differentiation (GO:0021879)2.94438418
128kinetochore organization (GO:0051383)2.92660395
129regulation of telomerase activity (GO:0051972)2.92462400
130positive regulation of calcium ion import (GO:0090280)2.91478523
131drug transport (GO:0015893)2.90996514
132response to X-ray (GO:0010165)2.89758929
133female gonad development (GO:0008585)2.88721776
134import into cell (GO:0098657)2.88605414
135DNA damage response, detection of DNA damage (GO:0042769)2.88314667
136serine family amino acid biosynthetic process (GO:0009070)2.88018793
137DNA double-strand break processing (GO:0000729)2.85886294
138dopaminergic neuron differentiation (GO:0071542)2.84268434
139negative regulation of DNA biosynthetic process (GO:2000279)2.84081337
140bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82785899
141regulation of centriole replication (GO:0046599)2.82242845
142regulation of megakaryocyte differentiation (GO:0045652)2.82131717
143telomere maintenance via telomere lengthening (GO:0010833)2.80298891
144folic acid-containing compound biosynthetic process (GO:0009396)2.79988170
145chromatin assembly or disassembly (GO:0006333)2.78290032
146interferon-gamma production (GO:0032609)2.76763310
147centrosome duplication (GO:0051298)2.75319937
148histone monoubiquitination (GO:0010390)2.74593777
149response to dietary excess (GO:0002021)2.72586489
150negative regulation of granulocyte differentiation (GO:0030853)2.69983055
151termination of G-protein coupled receptor signaling pathway (GO:0038032)2.63160708
152positive regulation of smoothened signaling pathway (GO:0045880)2.61268417
153sphingosine metabolic process (GO:0006670)2.59169254
154potassium ion export (GO:0071435)2.59106225
155amyloid precursor protein catabolic process (GO:0042987)2.57935008
156negative regulation of meiotic cell cycle (GO:0051447)2.57780870
157meiotic chromosome segregation (GO:0045132)2.56214115
158negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55988366
159mesenchymal-epithelial cell signaling (GO:0060638)2.55192772
160negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.54641822
161glycosylceramide metabolic process (GO:0006677)2.54410313
162negative regulation of lipase activity (GO:0060192)2.51128644
163tongue development (GO:0043586)2.50806748
164negative regulation of cell-matrix adhesion (GO:0001953)2.49892369
165detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47155687
166androgen metabolic process (GO:0008209)2.45432910
167positive regulation of protein kinase C signaling (GO:0090037)2.45421810
168phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44142256
169regulation of helicase activity (GO:0051095)2.43974038
170regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.43304002
171nucleoside transport (GO:0015858)2.43080900
172sulfate transmembrane transport (GO:1902358)2.42504913
173hair follicle development (GO:0001942)2.42061752
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40258744
175negative regulation by host of viral transcription (GO:0043922)2.39836638
176regulation of T cell chemotaxis (GO:0010819)2.39819772
177positive regulation of T cell chemotaxis (GO:0010820)2.39819772
178cellular response to exogenous dsRNA (GO:0071360)2.39719660
179regulation of platelet aggregation (GO:0090330)2.39432348
180vagina development (GO:0060068)2.39384488
181cranial nerve morphogenesis (GO:0021602)2.38991834
182positive regulation of interleukin-8 secretion (GO:2000484)2.38800828
183mesenchymal cell differentiation involved in kidney development (GO:0072161)2.38725193
184mesenchymal cell differentiation involved in renal system development (GO:2001012)2.38725193
185regulation of granulocyte differentiation (GO:0030852)2.38375743
186activated T cell proliferation (GO:0050798)2.37336335
187cell fate commitment involved in formation of primary germ layer (GO:0060795)2.36373308
188RNA-dependent DNA replication (GO:0006278)2.34854450
189modulation by virus of host process (GO:0019054)2.34763802
190regulation of lymphocyte chemotaxis (GO:1901623)2.34040484
191interferon-gamma secretion (GO:0072643)2.33932434
192negative regulation of osteoblast proliferation (GO:0033689)2.33486554
193segment specification (GO:0007379)2.31690414
194cellular anion homeostasis (GO:0030002)2.30654274
195pharyngeal system development (GO:0060037)2.30071860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18899401
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.87605575
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.87605575
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.87605575
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.81211928
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.76679591
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66352082
8EZH2_22144423_ChIP-Seq_EOC_Human3.45433446
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09080013
10GBX2_23144817_ChIP-Seq_PC3_Human2.93353567
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90357544
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89677342
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.72355400
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70161369
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62939247
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62775822
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.56709891
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.56388728
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53029879
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51619770
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48312977
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.46081084
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43033645
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35403970
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.34955268
26NANOG_16153702_ChIP-ChIP_HESCs_Human2.27092995
27IGF1R_20145208_ChIP-Seq_DFB_Human2.26047832
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21943514
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.20305870
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19557711
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.17814279
32SOX2_16153702_ChIP-ChIP_HESCs_Human2.17380473
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.15761354
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12384812
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11575888
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.11101981
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10293387
38TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09602791
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.09223000
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.07200959
41BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06766308
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06005407
43PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04784304
44NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04625232
45E2F1_21310950_ChIP-Seq_MCF-7_Human2.01649722
46SUZ12_27294783_Chip-Seq_NPCs_Mouse2.01010266
47GABP_17652178_ChIP-ChIP_JURKAT_Human2.00169601
48RNF2_27304074_Chip-Seq_NSC_Mouse2.00156149
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99474403
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99445784
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.99434132
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92143487
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.91129683
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90433636
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89890782
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.88360109
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87163211
58AR_21909140_ChIP-Seq_LNCAP_Human1.81749694
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81512539
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80522933
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80522933
62NMYC_18555785_Chip-Seq_ESCs_Mouse1.80052709
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.78134363
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78096393
65DROSHA_22980978_ChIP-Seq_HELA_Human1.76604461
66HTT_18923047_ChIP-ChIP_STHdh_Human1.76338555
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76299217
68P53_22387025_ChIP-Seq_ESCs_Mouse1.76047106
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75601503
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74904489
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74561932
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.73485136
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.72051705
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71884377
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70633311
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.69598523
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68913475
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67736779
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67041761
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.66659493
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.65581845
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.63639372
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.61432592
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61311046
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60765110
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60408762
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60366768
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.59823413
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59775312
90ELK1_19687146_ChIP-ChIP_HELA_Human1.56616711
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56072721
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56070230
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.55833183
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55810264
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55080700
96P300_18555785_Chip-Seq_ESCs_Mouse1.53026288
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51883726
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.51682791
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.51222073
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50980367
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50180974
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49149339
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48680959
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.45465189
105TTF2_22483619_ChIP-Seq_HELA_Human1.45461230
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45323259
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45143790
108PU1_27457419_Chip-Seq_LIVER_Mouse1.44859541
109FOXP3_21729870_ChIP-Seq_TREG_Human1.44822094
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.44719276
111TP53_18474530_ChIP-ChIP_U2OS_Human1.40881917
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40709946
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40646714
114SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38826806
115KDM2B_26808549_Chip-Seq_REH_Human1.37540411
116AR_21572438_ChIP-Seq_LNCaP_Human1.36027671
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35757981
118MYC_18940864_ChIP-ChIP_HL60_Human1.35109312
119STAT3_23295773_ChIP-Seq_U87_Human1.34893251
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33983801
121XRN2_22483619_ChIP-Seq_HELA_Human1.32501776
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31523166
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30618396
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30545741
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30489749
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.29961867
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28986185
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25979464
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24413521
130KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24329637
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24240985
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24001308
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20911876
134P300_19829295_ChIP-Seq_ESCs_Human1.19859137
135SALL1_21062744_ChIP-ChIP_HESCs_Human1.18939055
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17963544
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17889321
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17259571
139POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16445415
140* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15948766
141EWS_26573619_Chip-Seq_HEK293_Human1.15031875
142STAT1_17558387_ChIP-Seq_HELA_Human1.14269708
143SMAD4_21799915_ChIP-Seq_A2780_Human1.13426643
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12784061
145SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10793898
146RING1B_27294783_Chip-Seq_ESCs_Mouse1.10473806
147ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10193135
148FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09860813
149YY1_21170310_ChIP-Seq_MESCs_Mouse1.09778190
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09326913
151ER_23166858_ChIP-Seq_MCF-7_Human1.09092408
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08736263
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08661704
154FUS_26573619_Chip-Seq_HEK293_Human1.08110741
155NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07805711
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07670271
157TP63_19390658_ChIP-ChIP_HaCaT_Human1.07388270
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06644466
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06257463
160TP53_20018659_ChIP-ChIP_R1E_Mouse1.05763027
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05076988
162DCP1A_22483619_ChIP-Seq_HELA_Human1.04991328
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04593277
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04432530
165TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04360711
166TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02792220
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02728255
168HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02280603
169REST_21632747_ChIP-Seq_MESCs_Mouse1.01462137
170VDR_22108803_ChIP-Seq_LS180_Human1.01426436
171NANOG_21062744_ChIP-ChIP_HESCs_Human1.01331564
172HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01228823
173CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01034821
174SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01028053
175TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00791725
176CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00450840
177KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99114615
178MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98480067
179ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98443755
180NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98036415
181VDR_23849224_ChIP-Seq_CD4+_Human0.97083508
182SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95656297
183E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95410746
184TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94935334
185POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94478126
186GABP_19822575_ChIP-Seq_HepG2_Human0.94147805
187NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93762689
188POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92449566
189DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91615600
190NANOG_16518401_ChIP-PET_MESCs_Mouse0.91111735
191CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89043694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.79772398
2MP0003693_abnormal_embryo_hatching4.24311768
3MP0005360_urolithiasis4.01052716
4MP0000579_abnormal_nail_morphology3.91321651
5MP0004957_abnormal_blastocyst_morpholog3.88814108
6MP0005257_abnormal_intraocular_pressure3.85142221
7MP0002102_abnormal_ear_morphology3.68550003
8MP0003111_abnormal_nucleus_morphology3.41013564
9MP0008057_abnormal_DNA_replication3.40265279
10MP0010094_abnormal_chromosome_stability3.30609297
11MP0008877_abnormal_DNA_methylation3.29138546
12MP0005451_abnormal_body_composition3.24479681
13MP0003890_abnormal_embryonic-extraembry3.21603927
14MP0001188_hyperpigmentation2.97362721
15MP0000569_abnormal_digit_pigmentation2.94578991
16MP0008058_abnormal_DNA_repair2.89325223
17MP0005645_abnormal_hypothalamus_physiol2.70399344
18MP0009672_abnormal_birth_weight2.59608200
19MP0005085_abnormal_gallbladder_physiolo2.56923939
20MP0008932_abnormal_embryonic_tissue2.55416612
21MP0002735_abnormal_chemical_nociception2.54188556
22MP0003077_abnormal_cell_cycle2.49583856
23MP0003011_delayed_dark_adaptation2.46214630
24MP0003941_abnormal_skin_development2.44798842
25MP0003567_abnormal_fetal_cardiomyocyte2.32122751
26MP0005171_absent_coat_pigmentation2.12638908
27MP0004142_abnormal_muscle_tone2.11235588
28MP0001730_embryonic_growth_arrest2.11084686
29MP0002876_abnormal_thyroid_physiology2.04480701
30MP0003119_abnormal_digestive_system1.98329298
31MP0004484_altered_response_of1.94617367
32MP0001293_anophthalmia1.94191342
33MP0000383_abnormal_hair_follicle1.90721589
34MP0008007_abnormal_cellular_replicative1.89698068
35MP0004133_heterotaxia1.88409556
36MP0002938_white_spotting1.87658817
37MP0003938_abnormal_ear_development1.81134704
38MP0005409_darkened_coat_color1.75263641
39MP0009764_decreased_sensitivity_to1.71669322
40MP0004742_abnormal_vestibular_system1.70086198
41MP0005423_abnormal_somatic_nervous1.69767451
42MP0002085_abnormal_embryonic_tissue1.69695171
43MP0001346_abnormal_lacrimal_gland1.68538673
44MP0003283_abnormal_digestive_organ1.68263764
45MP0010352_gastrointestinal_tract_polyps1.65630786
46MP0000350_abnormal_cell_proliferation1.64513133
47MP0001502_abnormal_circadian_rhythm1.61919657
48MP0002084_abnormal_developmental_patter1.60504943
49MP0001672_abnormal_embryogenesis/_devel1.59032176
50MP0005380_embryogenesis_phenotype1.59032176
51MP0001968_abnormal_touch/_nociception1.58679158
52MP0003646_muscle_fatigue1.58397770
53MP0001486_abnormal_startle_reflex1.51006196
54MP0000026_abnormal_inner_ear1.49886158
55MP0002796_impaired_skin_barrier1.49730397
56MP0002697_abnormal_eye_size1.49610627
57MP0004859_abnormal_synaptic_plasticity1.47778990
58MP0000762_abnormal_tongue_morphology1.44908067
59MP0001697_abnormal_embryo_size1.42121372
60MP0003868_abnormal_feces_composition1.41789241
61MP0009703_decreased_birth_body1.39543117
62MP0002184_abnormal_innervation1.39151056
63MP0004197_abnormal_fetal_growth/weight/1.39139917
64MP0001986_abnormal_taste_sensitivity1.36329342
65MP0003984_embryonic_growth_retardation1.34883593
66MP0003252_abnormal_bile_duct1.33356706
67MP0003880_abnormal_central_pattern1.32678214
68MP0001963_abnormal_hearing_physiology1.31589299
69MP0002088_abnormal_embryonic_growth/wei1.31469873
70MP0004270_analgesia1.31372143
71MP0002277_abnormal_respiratory_mucosa1.29304642
72MP0002080_prenatal_lethality1.29051263
73MP0002734_abnormal_mechanical_nocicepti1.25963481
74MP0004019_abnormal_vitamin_homeostasis1.23569614
75MP0001286_abnormal_eye_development1.20780834
76MP0010678_abnormal_skin_adnexa1.20433329
77MP0000490_abnormal_crypts_of1.20301308
78MP0003787_abnormal_imprinting1.19226979
79MP0004782_abnormal_surfactant_physiolog1.19225806
80MP0000537_abnormal_urethra_morphology1.19113315
81MP0002234_abnormal_pharynx_morphology1.18503668
82MP0003136_yellow_coat_color1.18292475
83MP0002111_abnormal_tail_morphology1.16732755
84MP0001873_stomach_inflammation1.16721783
85MP0002736_abnormal_nociception_after1.14281519
86MP0001440_abnormal_grooming_behavior1.14152972
87MP0000681_abnormal_thyroid_gland1.13842076
88MP0002282_abnormal_trachea_morphology1.13561670
89MP0005165_increased_susceptibility_to1.13166769
90MP0010307_abnormal_tumor_latency1.12926881
91MP0003635_abnormal_synaptic_transmissio1.12750865
92MP0003121_genomic_imprinting1.11693840
93MP0004510_myositis1.08807950
94MP0009697_abnormal_copulation1.08799663
95MP0002396_abnormal_hematopoietic_system1.06718077
96MP0003123_paternal_imprinting1.03227267
97MP0000049_abnormal_middle_ear1.03014660
98MP0001177_atelectasis1.02706030
99MP0002139_abnormal_hepatobiliary_system1.01585824
100MP0006035_abnormal_mitochondrial_morpho1.01106771
101MP0008874_decreased_physiological_sensi1.00574150
102MP0001905_abnormal_dopamine_level1.00452124
103MP0002086_abnormal_extraembryonic_tissu0.99079876
104MP0003861_abnormal_nervous_system0.98657070
105MP0002249_abnormal_larynx_morphology0.96737156
106MP0002090_abnormal_vision0.95906926
107MP0005670_abnormal_white_adipose0.95710090
108MP0002067_abnormal_sensory_capabilities0.95375397
109MP0000313_abnormal_cell_death0.94159165
110MP0006292_abnormal_olfactory_placode0.94066522
111MP0002089_abnormal_postnatal_growth/wei0.93878339
112MP0000467_abnormal_esophagus_morphology0.92982687
113MP0000639_abnormal_adrenal_gland0.92274731
114MP0000428_abnormal_craniofacial_morphol0.92077601
115MP0002733_abnormal_thermal_nociception0.90966023
116MP0001299_abnormal_eye_distance/0.89152232
117MP0000432_abnormal_head_morphology0.88731986
118MP0002932_abnormal_joint_morphology0.85309609
119MP0008260_abnormal_autophagy0.84646477
120MP0005167_abnormal_blood-brain_barrier0.83670403
121MP0003718_maternal_effect0.83648353
122MP0001849_ear_inflammation0.83411083
123MP0005395_other_phenotype0.82223833
124MP0010030_abnormal_orbit_morphology0.81824929
125MP0000767_abnormal_smooth_muscle0.81794332
126MP0002572_abnormal_emotion/affect_behav0.79944803
127MP0005501_abnormal_skin_physiology0.79859813
128MP0009278_abnormal_bone_marrow0.79345354
129MP0006276_abnormal_autonomic_nervous0.78334271
130MP0005248_abnormal_Harderian_gland0.77170344
131MP0009046_muscle_twitch0.76281220
132MP0002210_abnormal_sex_determination0.76202055
133MP0005647_abnormal_sex_gland0.75931535
134MP0004185_abnormal_adipocyte_glucose0.75786552
135MP0001727_abnormal_embryo_implantation0.75371724
136MP0002177_abnormal_outer_ear0.75056263
137MP0008770_decreased_survivor_rate0.74751266
138MP0001145_abnormal_male_reproductive0.74703087
139MP0002233_abnormal_nose_morphology0.74354372
140MP0006072_abnormal_retinal_apoptosis0.74064887
141MP0001663_abnormal_digestive_system0.73727860
142MP0002751_abnormal_autonomic_nervous0.71695194
143MP0002295_abnormal_pulmonary_circulatio0.69992070
144MP0003937_abnormal_limbs/digits/tail_de0.68786423
145MP0002148_abnormal_hypersensitivity_rea0.68753797
146MP0002272_abnormal_nervous_system0.68244484
147MP0009379_abnormal_foot_pigmentation0.67213744
148MP0004233_abnormal_muscle_weight0.66780290
149MP0004272_abnormal_basement_membrane0.66263284
150MP0000343_altered_response_to0.65721551
151MP0001929_abnormal_gametogenesis0.65597781
152MP0008872_abnormal_physiological_respon0.65370136
153MP0004264_abnormal_extraembryonic_tissu0.65201949
154MP0001485_abnormal_pinna_reflex0.65179220
155MP0000678_abnormal_parathyroid_gland0.64555497
156MP0002138_abnormal_hepatobiliary_system0.63310259
157MP0002063_abnormal_learning/memory/cond0.63297750
158MP0000653_abnormal_sex_gland0.62410750
159MP0009745_abnormal_behavioral_response0.60989878
160MP0001348_abnormal_lacrimal_gland0.60248304
161MP0003566_abnormal_cell_adhesion0.59865257
162MP0003315_abnormal_perineum_morphology0.59574743
163MP0002254_reproductive_system_inflammat0.59061214
164MP0005377_hearing/vestibular/ear_phenot0.58670695
165MP0003878_abnormal_ear_physiology0.58670695
166MP0002723_abnormal_immune_serum0.58151491
167MP0001119_abnormal_female_reproductive0.58000916
168MP0003786_premature_aging0.55403438
169MP0009053_abnormal_anal_canal0.55194430
170MP0003115_abnormal_respiratory_system0.55170496
171MP0002081_perinatal_lethality0.54919263
172MP0003755_abnormal_palate_morphology0.53749191
173MP0003935_abnormal_craniofacial_develop0.53180760
174MP0000647_abnormal_sebaceous_gland0.52768581
175MP0003698_abnormal_male_reproductive0.51551817
176MP0002161_abnormal_fertility/fecundity0.51460671
177MP0003186_abnormal_redox_activity0.50792610
178MP0000631_abnormal_neuroendocrine_gland0.50536412
179MP0001984_abnormal_olfaction0.49768854
180MP0000358_abnormal_cell_content/0.48940663

Predicted human phenotypes

RankGene SetZ-score
1Mesomelia (HP:0003027)4.99684613
2Abnormality of the labia minora (HP:0012880)4.90101703
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57985494
4Intrahepatic cholestasis (HP:0001406)4.53699693
5Colon cancer (HP:0003003)4.46631030
6Upper limb muscle weakness (HP:0003484)4.41959834
7Chromsome breakage (HP:0040012)4.13565673
8Recurrent cutaneous fungal infections (HP:0011370)3.84835284
9Chronic mucocutaneous candidiasis (HP:0002728)3.84835284
10Birth length less than 3rd percentile (HP:0003561)3.75730485
11Septo-optic dysplasia (HP:0100842)3.69160747
12Panhypogammaglobulinemia (HP:0003139)3.65957297
13Increased corneal curvature (HP:0100692)3.55765010
14Keratoconus (HP:0000563)3.55765010
15Decreased central vision (HP:0007663)3.55177403
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.50546127
17Nephroblastoma (Wilms tumor) (HP:0002667)3.50178226
18Hepatoblastoma (HP:0002884)3.43880742
19Optic nerve hypoplasia (HP:0000609)3.43607578
20Erythroderma (HP:0001019)3.42453278
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38122762
22Aplasia cutis congenita (HP:0001057)3.35922966
23Distal lower limb amyotrophy (HP:0008944)3.35526776
24Obstructive lung disease (HP:0006536)3.32666375
25Chronic obstructive pulmonary disease (HP:0006510)3.32666375
26Embryonal renal neoplasm (HP:0011794)3.29939970
27Multiple enchondromatosis (HP:0005701)3.29450082
28Spastic diplegia (HP:0001264)3.26671419
29Tetany (HP:0001281)3.17435448
30Lower limb amyotrophy (HP:0007210)3.16946769
31Distal lower limb muscle weakness (HP:0009053)3.11745357
32Bilateral microphthalmos (HP:0007633)3.10537194
33Choanal stenosis (HP:0000452)3.01359384
34Selective tooth agenesis (HP:0001592)2.96405047
35Prostate neoplasm (HP:0100787)2.95080148
36Febrile seizures (HP:0002373)2.94668714
37Unilateral renal agenesis (HP:0000122)2.93651031
38Cutaneous melanoma (HP:0012056)2.92686109
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.89993880
40Double outlet right ventricle (HP:0001719)2.88883547
41Congenital malformation of the right heart (HP:0011723)2.88883547
42Abnormal lung lobation (HP:0002101)2.88617913
43Prolonged neonatal jaundice (HP:0006579)2.87791005
44Ependymoma (HP:0002888)2.83992707
45Chin dimple (HP:0010751)2.83960973
46Chronic bronchitis (HP:0004469)2.80604023
47Focal motor seizures (HP:0011153)2.75829067
48Meckel diverticulum (HP:0002245)2.74297618
49Homocystinuria (HP:0002156)2.71035029
50Abnormality of homocysteine metabolism (HP:0010919)2.71035029
51Absent septum pellucidum (HP:0001331)2.63327368
52Status epilepticus (HP:0002133)2.58960078
53Abnormality of the ileum (HP:0001549)2.56943323
54Hyperglycinuria (HP:0003108)2.55832504
55Hyperglycinemia (HP:0002154)2.55572735
56Flat cornea (HP:0007720)2.55166107
57Prolonged bleeding time (HP:0003010)2.54173426
58Absent radius (HP:0003974)2.52477069
59Stenosis of the external auditory canal (HP:0000402)2.51010177
60Metabolic alkalosis (HP:0200114)2.49296789
61Attenuation of retinal blood vessels (HP:0007843)2.48430279
62Abnormality of chromosome stability (HP:0003220)2.48172361
63Rhabdomyosarcoma (HP:0002859)2.47916357
64Gastrointestinal stroma tumor (HP:0100723)2.46058770
65Maternal diabetes (HP:0009800)2.45475329
66Abnormality of serum amino acid levels (HP:0003112)2.43512200
67Cortical dysplasia (HP:0002539)2.40281892
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.38342291
69Recurrent fungal infections (HP:0002841)2.37754709
70Absent forearm bone (HP:0003953)2.37258561
71Aplasia involving forearm bones (HP:0009822)2.37258561
72Abnormality of serine family amino acid metabolism (HP:0010894)2.35828862
73Abnormality of glycine metabolism (HP:0010895)2.35828862
74Elfin facies (HP:0004428)2.35048600
75Breast aplasia (HP:0100783)2.32142818
76Fat malabsorption (HP:0002630)2.30189638
77Hypoglycemic seizures (HP:0002173)2.28418713
78Elevated erythrocyte sedimentation rate (HP:0003565)2.27441961
79Anomalous pulmonary venous return (HP:0010772)2.26341605
80Abnormal ciliary motility (HP:0012262)2.25416900
81Onion bulb formation (HP:0003383)2.25360408
82Biliary tract neoplasm (HP:0100574)2.24711121
83Hypoplasia of the pons (HP:0012110)2.24449436
84Recurrent skin infections (HP:0001581)2.23585099
85Neoplasm of the adrenal cortex (HP:0100641)2.23266646
86Sensory axonal neuropathy (HP:0003390)2.21825189
87Fragile nails (HP:0001808)2.18786087
88Short hallux (HP:0010109)2.17721054
89Genetic anticipation (HP:0003743)2.17408587
90Ectopic kidney (HP:0000086)2.15884563
91White forelock (HP:0002211)2.15864845
92Vasculitis (HP:0002633)2.15566299
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.15239350
94Aplasia/Hypoplasia of the breasts (HP:0010311)2.15217556
95Congenital stationary night blindness (HP:0007642)2.15040568
96Abnormality of the prostate (HP:0008775)2.15027281
97Agnosia (HP:0010524)2.14387388
98Fetal akinesia sequence (HP:0001989)2.13478380
99Carpal bone hypoplasia (HP:0001498)2.13104551
100Facial cleft (HP:0002006)2.12556762
101Abnormality of the preputium (HP:0100587)2.12444749
102Abnormality of the septum pellucidum (HP:0007375)2.12134919
103Congenital ichthyosiform erythroderma (HP:0007431)2.11287215
104Renovascular hypertension (HP:0100817)2.11086224
105Azoospermia (HP:0000027)2.10779653
106Medulloblastoma (HP:0002885)2.10387270
107Renal duplication (HP:0000075)2.10132175
108Generalized tonic-clonic seizures (HP:0002069)2.08852987
109Increased nuchal translucency (HP:0010880)2.08778360
110Abnormal hair whorl (HP:0010721)2.07138077
111Reduced antithrombin III activity (HP:0001976)2.06220527
112Inflammation of the large intestine (HP:0002037)2.05966582
113Abdominal situs inversus (HP:0003363)2.05333852
114Abnormality of abdominal situs (HP:0011620)2.05333852
115Aplasia/Hypoplasia of the hallux (HP:0008362)2.05039469
116Congenital sensorineural hearing impairment (HP:0008527)2.05023709
117Sensorimotor neuropathy (HP:0007141)2.05022194
118Aplasia/Hypoplasia of the uvula (HP:0010293)2.04740289
119Neoplasm of the colon (HP:0100273)2.04179147
120Impulsivity (HP:0100710)2.04028118
121Osteomalacia (HP:0002749)2.03608523
122Malignant gastrointestinal tract tumors (HP:0006749)2.03285391
123Gastrointestinal carcinoma (HP:0002672)2.03285391
124Broad palm (HP:0001169)2.02951774
125Abnormal number of incisors (HP:0011064)2.01759553
126Premature ovarian failure (HP:0008209)2.01710006
127Abnormality of the pons (HP:0007361)2.01278155
128Esophageal atresia (HP:0002032)2.00245593
129Pancreatic islet-cell hyperplasia (HP:0004510)2.00158469
130Tubulointerstitial nephritis (HP:0001970)1.99517033
131Chronic hepatic failure (HP:0100626)1.98890560
132Atelectasis (HP:0100750)1.98560244
133Syncope (HP:0001279)1.97649759
134Embryonal neoplasm (HP:0002898)1.96820967
135Overriding aorta (HP:0002623)1.96005425
136Type I transferrin isoform profile (HP:0003642)1.94641538
137Pruritus (HP:0000989)1.94416747
138Cellular immunodeficiency (HP:0005374)1.93201275
139Horseshoe kidney (HP:0000085)1.92748811
140Glioma (HP:0009733)1.92531861
141Myelomeningocele (HP:0002475)1.92061357
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91942007
143Duodenal stenosis (HP:0100867)1.91387179
144Small intestinal stenosis (HP:0012848)1.91387179
145Dysmetric saccades (HP:0000641)1.91149752
146Aqueductal stenosis (HP:0002410)1.90718240
147Abnormality of the pulmonary veins (HP:0011718)1.90576087
148Hypokalemic alkalosis (HP:0001949)1.90311782
149Skull defect (HP:0001362)1.89359334
150Abnormality of the duodenum (HP:0002246)1.89242749
151Absent speech (HP:0001344)1.89156066
152Squamous cell carcinoma (HP:0002860)1.89009853
153Rectal fistula (HP:0100590)1.88836016
154Rectovaginal fistula (HP:0000143)1.88836016
155Uterine neoplasm (HP:0010784)1.88760158
156Absent eyebrow (HP:0002223)1.88565035
157Abnormality of the clitoris (HP:0000056)1.88066207
158Chorioretinal coloboma (HP:0000567)1.88038173
159Decreased subcutaneous fat (HP:0001002)1.87456246
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87105114
161Hypoplastic female external genitalia (HP:0012815)1.86540502
162Midline defect of the nose (HP:0004122)1.85991952
163Corneal erosion (HP:0200020)1.85987284
164Reticulocytopenia (HP:0001896)1.85630456
165External ophthalmoplegia (HP:0000544)1.84432210
166Abnormality of the parietal bone (HP:0002696)1.84422544
167Renal cortical cysts (HP:0000803)1.84344431
168Interstitial pulmonary disease (HP:0006530)1.83217857
169Chorioretinal atrophy (HP:0000533)1.82758178
170Emphysema (HP:0002097)1.82594640
171Intestinal fistula (HP:0100819)1.81819668
172Hypoparathyroidism (HP:0000829)1.81785493
173Abnormal number of erythroid precursors (HP:0012131)1.80145561
174Abnormality of T cell physiology (HP:0011840)1.79366338
175Peripheral demyelination (HP:0011096)1.78379465
176Progressive external ophthalmoplegia (HP:0000590)1.78146998
177Volvulus (HP:0002580)1.77923720
178Clitoromegaly (HP:0000057)1.77831553
179Abnormality of the diencephalon (HP:0010662)1.77566743
180Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77147235
181Basal ganglia calcification (HP:0002135)1.77124859
182Abnormality of the lacrimal duct (HP:0011481)1.76779146
183Agammaglobulinemia (HP:0004432)1.76408199
184Bifid tongue (HP:0010297)1.75777063
185Viral hepatitis (HP:0006562)1.75354645
186Abnormality of methionine metabolism (HP:0010901)1.75010000
187Pustule (HP:0200039)1.74833701
188Patchy hypopigmentation of hair (HP:0011365)1.74818076
189Aplasia of the musculature (HP:0100854)1.74620616
190Encephalitis (HP:0002383)1.73278417
191Facial hemangioma (HP:0000329)1.72758218
192Patellar dislocation (HP:0002999)1.70011126
193Colitis (HP:0002583)1.69863376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK9.71977706
2CDC74.39038165
3STK38L3.86528635
4BUB13.53292471
5STK243.21945438
6TNIK3.03606402
7VRK23.01453845
8TAF12.98408190
9TSSK62.81774994
10SIK22.80349453
11MKNK12.78919234
12EIF2AK22.61466826
13PLK32.52048377
14CDK192.44660140
15MST42.37434620
16SRPK12.33536542
17PBK2.27623614
18ZAK2.27289166
19SIK32.13732367
20MUSK1.97129563
21MAP3K61.96282160
22PLK41.95467909
23MAP3K101.83433915
24CDK121.71278933
25IRAK31.69369594
26ADRBK21.66648811
27SMG11.62510057
28PRKD21.57030609
29IRAK21.55570399
30STK31.50238974
31ALK1.47428514
32PKN11.42816733
33BRAF1.38626180
34DYRK31.38477357
35PASK1.37784388
36NEK21.35475859
37BRSK21.34436509
38SIK11.33644324
39CHEK21.32045363
40BRD41.29211536
41FGR1.27186441
42ACVR1B1.25117125
43PIK3CG1.24733628
44VRK11.23788086
45NEK11.22270232
46TRIM281.22050546
47IRAK41.19099127
48NME11.17571020
49TXK1.16760689
50OXSR11.14034909
51WEE11.13485361
52MAP3K91.13428789
53GRK11.10790511
54FGFR11.08929507
55CSNK1A1L1.07865773
56ATR1.05744884
57NTRK31.04547125
58STK161.03555564
59BMPR1B1.02609078
60KIT1.02543939
61PRPF4B1.01264528
62MAP2K70.99499743
63PAK60.98559409
64FGFR20.96105765
65CHEK10.93527680
66BMX0.91007177
67CSNK1G30.90170488
68ATM0.86933364
69MST1R0.86720483
70NTRK10.86367969
71TTK0.85919538
72STK390.85188107
73JAK10.84968632
74CDK70.82225359
75OBSCN0.81373999
76CAMK10.80882814
77INSRR0.78759761
78AURKB0.77647012
79MARK30.76804031
80LATS20.74548918
81ERBB40.73816581
82CSF1R0.73545074
83STK110.73389699
84CAMK1D0.71654752
85EEF2K0.69641197
86AKT20.68684564
87LATS10.67878363
88PAK40.66847755
89TIE10.65340545
90PIM10.65288025
91MAPK110.64334414
92TBK10.64198756
93MET0.63125616
94CSNK1E0.63082115
95CSNK1G10.61820137
96CDK10.61701312
97STK40.59794128
98JAK30.59189919
99CAMK2A0.58642262
100CDK20.58339118
101PNCK0.58332498
102MARK10.57079112
103MAP3K40.57045791
104BRSK10.56613889
105GRK70.56296787
106PRKDC0.56260222
107CLK10.56248910
108PAK30.55587519
109EIF2AK30.55500557
110PRKAA20.54642805
111CSNK1G20.53954007
112KDR0.53145438
113MAPK130.53095633
114DMPK0.52256315
115MARK20.51980712
116FES0.51183680
117TEC0.50560512
118ARAF0.49066186
119CSNK2A10.48512909
120WNK30.47372965
121PLK10.46850162
122MKNK20.46724056
123MAP3K80.46481963
124FRK0.45644477
125FLT30.45372406
126MAP3K50.45103455
127PIM20.44761144
128CDK40.43411802
129PRKCE0.43392087
130DAPK10.43047545
131RPS6KB20.43031181
132CAMK1G0.42865292
133IKBKE0.42821753
134IRAK10.42120074
135TGFBR10.42001794
136AURKA0.41717408
137EGFR0.41607701
138TGFBR20.41503339
139CSNK2A20.40881816
140PRKCH0.39993089
141DYRK20.39838863
142CDK30.39514355
143RPS6KA40.38433305
144NTRK20.38166468
145RET0.37990898
146WNK40.37788975
147CDK50.35359854
148MELK0.34355975
149DYRK1A0.34166933
150DDR20.33879632
151GSK3B0.33510484
152MAP3K140.32570716
153CDK90.32138110
154PLK20.31832240
155PRKCQ0.30861086
156YES10.28685576
157MAPK140.27641931
158EIF2AK10.27565368
159PRKCG0.27225000
160MOS0.27170384
161PRKG20.26323324
162EPHB10.25915744
163CAMK2G0.25755721
164BLK0.24931524
165PAK10.24919152
166PDK10.24805421
167PRKAA10.24652995
168LYN0.24593457
169MAP3K70.24450414
170PRKG10.24059348
171PRKACA0.23837990
172NLK0.22825608
173NUAK10.22224696
174CAMK2B0.21203728
175FER0.21142171

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.88442876
2Mismatch repair_Homo sapiens_hsa034303.87888110
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35224606
4Nicotine addiction_Homo sapiens_hsa050333.30470776
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.14741123
6Non-homologous end-joining_Homo sapiens_hsa034502.92764309
7Homologous recombination_Homo sapiens_hsa034402.86584550
8RNA polymerase_Homo sapiens_hsa030202.70098645
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67633048
10RNA transport_Homo sapiens_hsa030132.61512902
11Proteasome_Homo sapiens_hsa030502.59542021
12Spliceosome_Homo sapiens_hsa030402.55725913
13Selenocompound metabolism_Homo sapiens_hsa004502.54134242
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.44584732
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.41485220
16Base excision repair_Homo sapiens_hsa034102.38245736
17Cell cycle_Homo sapiens_hsa041102.30135523
18Steroid biosynthesis_Homo sapiens_hsa001002.29798265
19Morphine addiction_Homo sapiens_hsa050322.19445899
20Basal transcription factors_Homo sapiens_hsa030222.01549160
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99958770
22mRNA surveillance pathway_Homo sapiens_hsa030151.90620356
23Ovarian steroidogenesis_Homo sapiens_hsa049131.87655973
24ABC transporters_Homo sapiens_hsa020101.87492797
25RNA degradation_Homo sapiens_hsa030181.83118604
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71295307
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69881826
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69231785
29Retinol metabolism_Homo sapiens_hsa008301.69170139
30Nucleotide excision repair_Homo sapiens_hsa034201.67525790
31Ribosome_Homo sapiens_hsa030101.66419877
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63639704
33Vitamin B6 metabolism_Homo sapiens_hsa007501.62113361
34Phototransduction_Homo sapiens_hsa047441.54899935
35Cocaine addiction_Homo sapiens_hsa050301.54776158
36Staphylococcus aureus infection_Homo sapiens_hsa051501.51797342
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50494772
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49861946
39Glutamatergic synapse_Homo sapiens_hsa047241.48089959
40Vitamin digestion and absorption_Homo sapiens_hsa049771.46907378
41Biosynthesis of amino acids_Homo sapiens_hsa012301.45797462
42Pyruvate metabolism_Homo sapiens_hsa006201.41635150
43Primary immunodeficiency_Homo sapiens_hsa053401.41160043
44Histidine metabolism_Homo sapiens_hsa003401.37537223
45Axon guidance_Homo sapiens_hsa043601.36619070
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.36613553
47Pyrimidine metabolism_Homo sapiens_hsa002401.30339978
48Propanoate metabolism_Homo sapiens_hsa006401.29520081
49beta-Alanine metabolism_Homo sapiens_hsa004101.28986234
50Amphetamine addiction_Homo sapiens_hsa050311.28847980
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28307243
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26202266
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25858319
54Linoleic acid metabolism_Homo sapiens_hsa005911.23422007
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22657251
56Protein export_Homo sapiens_hsa030601.21524019
57Ether lipid metabolism_Homo sapiens_hsa005651.19176050
58Collecting duct acid secretion_Homo sapiens_hsa049661.18655040
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17270366
60Taste transduction_Homo sapiens_hsa047421.16727211
61Purine metabolism_Homo sapiens_hsa002301.16194462
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15707706
63Tryptophan metabolism_Homo sapiens_hsa003801.15068268
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14993524
65Lysine degradation_Homo sapiens_hsa003101.14653406
66Salivary secretion_Homo sapiens_hsa049701.14475210
67Complement and coagulation cascades_Homo sapiens_hsa046101.14021377
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13587699
69ECM-receptor interaction_Homo sapiens_hsa045121.13528733
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12984650
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12646173
72Hematopoietic cell lineage_Homo sapiens_hsa046401.12196884
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11551117
74Adherens junction_Homo sapiens_hsa045201.10594955
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10217200
76Butanoate metabolism_Homo sapiens_hsa006501.09674635
77African trypanosomiasis_Homo sapiens_hsa051431.08128919
78Tight junction_Homo sapiens_hsa045301.04198262
79Amoebiasis_Homo sapiens_hsa051461.02978023
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01390423
81p53 signaling pathway_Homo sapiens_hsa041151.00603819
82Olfactory transduction_Homo sapiens_hsa047401.00183484
83Oocyte meiosis_Homo sapiens_hsa041140.99970922
84Arginine and proline metabolism_Homo sapiens_hsa003300.99870766
85Chemokine signaling pathway_Homo sapiens_hsa040620.95795376
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94379333
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93400698
88Basal cell carcinoma_Homo sapiens_hsa052170.92538548
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91808302
90Carbon metabolism_Homo sapiens_hsa012000.90868117
91GABAergic synapse_Homo sapiens_hsa047270.90515196
92Thyroid cancer_Homo sapiens_hsa052160.90069344
93Synaptic vesicle cycle_Homo sapiens_hsa047210.89170910
94Chemical carcinogenesis_Homo sapiens_hsa052040.89113262
95Huntingtons disease_Homo sapiens_hsa050160.88688481
96Hippo signaling pathway_Homo sapiens_hsa043900.87649984
97Galactose metabolism_Homo sapiens_hsa000520.86272250
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86110417
99Phenylalanine metabolism_Homo sapiens_hsa003600.86097231
100Calcium signaling pathway_Homo sapiens_hsa040200.84934735
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.82162006
102Phagosome_Homo sapiens_hsa041450.80774581
103Serotonergic synapse_Homo sapiens_hsa047260.79902329
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79012450
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78144795
106Arachidonic acid metabolism_Homo sapiens_hsa005900.77190376
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74914525
108Dilated cardiomyopathy_Homo sapiens_hsa054140.71720660
109Fanconi anemia pathway_Homo sapiens_hsa034600.71357954
110Parkinsons disease_Homo sapiens_hsa050120.67433953
111Rheumatoid arthritis_Homo sapiens_hsa053230.66717010
112Ras signaling pathway_Homo sapiens_hsa040140.66517605
113Renin secretion_Homo sapiens_hsa049240.66018555
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65928389
115Dorso-ventral axis formation_Homo sapiens_hsa043200.65523957
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.65020886
117Glutathione metabolism_Homo sapiens_hsa004800.64820243
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64424161
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.64334733
120Folate biosynthesis_Homo sapiens_hsa007900.63395048
121Notch signaling pathway_Homo sapiens_hsa043300.61340869
122Fatty acid elongation_Homo sapiens_hsa000620.60663942
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59390992
124Small cell lung cancer_Homo sapiens_hsa052220.59385946
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58927744
126Inositol phosphate metabolism_Homo sapiens_hsa005620.58621534
127Regulation of autophagy_Homo sapiens_hsa041400.58408672
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58100648
129Insulin secretion_Homo sapiens_hsa049110.57760172
130Hedgehog signaling pathway_Homo sapiens_hsa043400.57741942
131MicroRNAs in cancer_Homo sapiens_hsa052060.57398457
132cAMP signaling pathway_Homo sapiens_hsa040240.56707027
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56368541
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55961715
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53271283
136Sulfur relay system_Homo sapiens_hsa041220.52323166
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51562865
138Wnt signaling pathway_Homo sapiens_hsa043100.51205140
139Tyrosine metabolism_Homo sapiens_hsa003500.50924405
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50611521
141Metabolic pathways_Homo sapiens_hsa011000.50127291
142Oxytocin signaling pathway_Homo sapiens_hsa049210.50001735
143TGF-beta signaling pathway_Homo sapiens_hsa043500.49818014
144Pathways in cancer_Homo sapiens_hsa052000.49734998
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48878194
146Graft-versus-host disease_Homo sapiens_hsa053320.47780067
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.46445269
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46335012
149Oxidative phosphorylation_Homo sapiens_hsa001900.46059403
150One carbon pool by folate_Homo sapiens_hsa006700.45853956
151Protein digestion and absorption_Homo sapiens_hsa049740.45610721
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45410693
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44707223
154Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44562053
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44244742
156Arginine biosynthesis_Homo sapiens_hsa002200.43709910
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41778542
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41351787
159Colorectal cancer_Homo sapiens_hsa052100.39038085
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36302016
161Fatty acid degradation_Homo sapiens_hsa000710.36139762
162Melanoma_Homo sapiens_hsa052180.36118603
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.34389116
164Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33405867
165Epstein-Barr virus infection_Homo sapiens_hsa051690.26876686
166Prostate cancer_Homo sapiens_hsa052150.24911598
167Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22672502
168Starch and sucrose metabolism_Homo sapiens_hsa005000.21049954
169Alzheimers disease_Homo sapiens_hsa050100.20026595
170Fat digestion and absorption_Homo sapiens_hsa049750.18905666
171Pentose phosphate pathway_Homo sapiens_hsa000300.17958763
172Fatty acid metabolism_Homo sapiens_hsa012120.16695968
173Cardiac muscle contraction_Homo sapiens_hsa042600.13435849

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