HHLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.26827315
2regulation of guanylate cyclase activity (GO:0031282)7.89778501
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.34934390
4intestinal absorption (GO:0050892)6.91753484
5positive regulation of guanylate cyclase activity (GO:0031284)6.12920640
6epoxygenase P450 pathway (GO:0019373)5.87788018
7lipoprotein transport (GO:0042953)5.42391196
8fat-soluble vitamin biosynthetic process (GO:0042362)5.29737210
9NADH metabolic process (GO:0006734)5.29115467
10regulation of bile acid biosynthetic process (GO:0070857)5.17376804
11cellular glucuronidation (GO:0052695)5.07038607
12glucuronate metabolic process (GO:0019585)4.99937885
13uronic acid metabolic process (GO:0006063)4.99937885
14regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.92154354
15endocrine process (GO:0050886)4.92154354
16regulation of systemic arterial blood pressure by hormone (GO:0001990)4.92154354
17regulation of cGMP biosynthetic process (GO:0030826)4.76848513
18digestion (GO:0007586)4.71381374
19receptor guanylyl cyclase signaling pathway (GO:0007168)4.70009654
20regulation of cellular extravasation (GO:0002691)4.58189345
21vitamin transmembrane transport (GO:0035461)4.57766608
22drug metabolic process (GO:0017144)4.52464109
23hormone catabolic process (GO:0042447)4.48224652
24bile acid and bile salt transport (GO:0015721)4.40101723
25maintenance of gastrointestinal epithelium (GO:0030277)4.39879332
26phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.38387765
27regulation of triglyceride catabolic process (GO:0010896)4.38130228
28regulation of systemic arterial blood pressure (GO:0003073)4.36330797
29glycine transport (GO:0015816)4.34226533
30flavonoid metabolic process (GO:0009812)4.15713609
31fructose metabolic process (GO:0006000)4.09474035
32positive regulation of respiratory burst (GO:0060267)4.07779105
33peptide catabolic process (GO:0043171)4.05236028
34peptide hormone processing (GO:0016486)4.00173313
35antibacterial humoral response (GO:0019731)3.99428241
36diacylglycerol metabolic process (GO:0046339)3.91678993
37sulfate transmembrane transport (GO:1902358)3.91185797
38calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.91100818
39renal system process involved in regulation of blood volume (GO:0001977)3.86612839
40cobalamin metabolic process (GO:0009235)3.86192618
41drinking behavior (GO:0042756)3.85294229
42regulation of cGMP metabolic process (GO:0030823)3.84860508
43antimicrobial humoral response (GO:0019730)3.81147404
44drug catabolic process (GO:0042737)3.74033020
45sulfur compound transport (GO:0072348)3.73935672
46O-glycan processing (GO:0016266)3.70788678
47transcytosis (GO:0045056)3.70356068
48exogenous drug catabolic process (GO:0042738)3.65626472
49regulation of vitamin metabolic process (GO:0030656)3.64921492
50adhesion of symbiont to host cell (GO:0044650)3.63973699
51virion attachment to host cell (GO:0019062)3.63973699
52digestive system process (GO:0022600)3.60787605
53vitamin A metabolic process (GO:0006776)3.59741491
54very-low-density lipoprotein particle assembly (GO:0034379)3.54638278
55arginine metabolic process (GO:0006525)3.52200163
56positive regulation of cGMP biosynthetic process (GO:0030828)3.51383710
57positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48070435
58ethanol oxidation (GO:0006069)3.45375885
59urea cycle (GO:0000050)3.42092965
60sphingomyelin metabolic process (GO:0006684)3.39363204
61oligosaccharide biosynthetic process (GO:0009312)3.37370434
62drug transmembrane transport (GO:0006855)3.36448821
63positive regulation of pseudopodium assembly (GO:0031274)3.34493303
64sulfate transport (GO:0008272)3.32513859
65vitamin transport (GO:0051180)3.30469369
66glycolipid catabolic process (GO:0019377)3.30223117
67bile acid metabolic process (GO:0008206)3.30025181
68urea metabolic process (GO:0019627)3.26700988
69citrulline biosynthetic process (GO:0019240)3.25665789
70phosphatidylserine acyl-chain remodeling (GO:0036150)3.21209915
71cellular response to pH (GO:0071467)3.20705163
72drug transport (GO:0015893)3.20493682
73pyrimidine-containing compound transmembrane transport (GO:0072531)3.19100573
74cilium or flagellum-dependent cell motility (GO:0001539)3.17676280
75plasma lipoprotein particle assembly (GO:0034377)3.16012450
76cGMP biosynthetic process (GO:0006182)3.14493892
77thrombin receptor signaling pathway (GO:0070493)3.13864745
78sperm capacitation (GO:0048240)3.13507287
79vitamin biosynthetic process (GO:0009110)3.13201340
80fat-soluble vitamin metabolic process (GO:0006775)3.12093809
81alkaloid metabolic process (GO:0009820)3.11652011
82axonemal dynein complex assembly (GO:0070286)3.09826042
83nitrogen cycle metabolic process (GO:0071941)3.09648435
84glycosylceramide metabolic process (GO:0006677)3.07418653
85transepithelial transport (GO:0070633)3.06552628
86positive regulation of glycoprotein metabolic process (GO:1903020)3.05940106
87glycerol metabolic process (GO:0006071)3.03958193
88homocysteine metabolic process (GO:0050667)3.03763431
89auditory receptor cell differentiation (GO:0042491)3.01883579
90excretion (GO:0007588)3.01620606
91sodium ion homeostasis (GO:0055078)2.99665457
92leukotriene metabolic process (GO:0006691)2.99141281
93cGMP-mediated signaling (GO:0019934)2.99127542
94phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.99084152
95nucleoside diphosphate biosynthetic process (GO:0009133)2.98654191
96L-fucose catabolic process (GO:0042355)2.94774820
97fucose catabolic process (GO:0019317)2.94774820
98L-fucose metabolic process (GO:0042354)2.94774820
99epithelial structure maintenance (GO:0010669)2.94634780
100cellular response to nitric oxide (GO:0071732)2.94258139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.52097656
2EZH2_22144423_ChIP-Seq_EOC_Human3.61764959
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07717832
4GATA4_25053715_ChIP-Seq_YYC3_Human2.98917815
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.73837393
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.64060901
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.61131454
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47438986
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34640009
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34189360
11GATA6_25053715_ChIP-Seq_YYC3_Human2.30866474
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15040772
13VDR_22108803_ChIP-Seq_LS180_Human2.08748129
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07020441
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98994880
16SOX2_20726797_ChIP-Seq_SW620_Human1.95584163
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95208313
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.87510506
19CDX2_22108803_ChIP-Seq_LS180_Human1.86295480
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.85854946
21* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.77038830
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74461338
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72703716
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72442969
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66430821
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.61499266
27* NANOG_20526341_ChIP-Seq_ESCs_Human1.61413643
28DROSHA_22980978_ChIP-Seq_HELA_Human1.60516904
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60224074
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.57433501
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55131845
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.53219423
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51358498
34FOXA1_25552417_ChIP-Seq_VCAP_Human1.50814864
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49929829
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44540905
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.43682989
38CEBPB_22108803_ChIP-Seq_LS180_Human1.41819224
39BCAT_22108803_ChIP-Seq_LS180_Human1.41397809
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39989619
41CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.35773128
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32106782
43* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31556589
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27256414
45STAT1_20625510_ChIP-Seq_HELA_Human1.27231331
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.25755851
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.24219317
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24219317
49AR_20517297_ChIP-Seq_VCAP_Human1.23716137
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22128052
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22033664
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17446734
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16296141
54KLF5_25053715_ChIP-Seq_YYC3_Human1.15300006
55NCOR_22424771_ChIP-Seq_293T_Human1.14915286
56TCF4_22108803_ChIP-Seq_LS180_Human1.12812734
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.11181316
58TAF2_19829295_ChIP-Seq_ESCs_Human1.10664348
59* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10295308
60CBP_21632823_ChIP-Seq_H3396_Human1.09600828
61BCOR_27268052_Chip-Seq_Bcells_Human1.09385678
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09345642
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.08191262
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07090810
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06806756
66RBPJ_21746931_ChIP-Seq_IB4_Human1.06566812
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05798448
68ETV1_20927104_ChIP-Seq_GIST48_Human1.04996061
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04488539
70* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04424180
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03937844
72MYC_19829295_ChIP-Seq_ESCs_Human1.03591138
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03152047
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02676044
75* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02528976
76P53_21459846_ChIP-Seq_SAOS-2_Human1.02210862
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01859546
78BCL6_27268052_Chip-Seq_Bcells_Human1.01847407
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.01472659
80GATA2_19941826_ChIP-Seq_K562_Human1.01439898
81* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00653933
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00388279
83RXR_22108803_ChIP-Seq_LS180_Human0.99475250
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.99468324
85* TP63_23658742_ChIP-Seq_EP156T_Human0.99244216
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99151696
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98998488
88CBP_20019798_ChIP-Seq_JUKART_Human0.97410541
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97410541
90P300_27268052_Chip-Seq_Bcells_Human0.97339924
91PHF8_20622853_ChIP-Seq_HELA_Human0.97146129
92NFYA_21822215_ChIP-Seq_K562_Human0.95972399
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95958998
94ERG_20517297_ChIP-Seq_VCAP_Human0.92267610
95NANOG_19829295_ChIP-Seq_ESCs_Human0.91994603
96SOX2_19829295_ChIP-Seq_ESCs_Human0.91994603
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91773007
98SOX2_21211035_ChIP-Seq_LN229_Human0.91671532
99NFYB_21822215_ChIP-Seq_K562_Human0.91460890
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.90981981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.77896685
2MP0002139_abnormal_hepatobiliary_system5.02708531
3MP0005085_abnormal_gallbladder_physiolo4.65135776
4MP0001666_abnormal_nutrient_absorption4.59850623
5MP0003183_abnormal_peptide_metabolism3.92138998
6MP0010234_abnormal_vibrissa_follicle3.68737051
7MP0005365_abnormal_bile_salt3.44911761
8MP0004019_abnormal_vitamin_homeostasis3.38667940
9MP0003718_maternal_effect3.37814660
10MP0004147_increased_porphyrin_level3.36561839
11MP0009379_abnormal_foot_pigmentation3.28440351
12MP0004264_abnormal_extraembryonic_tissu2.82430186
13MP0009840_abnormal_foam_cell2.78436894
14MP0010155_abnormal_intestine_physiology2.49814118
15MP0001664_abnormal_digestion2.43407963
16MP0004043_abnormal_pH_regulation2.26471140
17MP0003866_abnormal_defecation2.16509815
18MP0001765_abnormal_ion_homeostasis1.98768119
19MP0002138_abnormal_hepatobiliary_system1.98022975
20MP0003252_abnormal_bile_duct1.94696753
21MP0003868_abnormal_feces_composition1.92608426
22MP0010329_abnormal_lipoprotein_level1.90707461
23MP0003879_abnormal_hair_cell1.83253214
24MP0005332_abnormal_amino_acid1.82021476
25MP0000678_abnormal_parathyroid_gland1.73808174
26MP0009643_abnormal_urine_homeostasis1.73566876
27MP0002876_abnormal_thyroid_physiology1.67157329
28MP0005636_abnormal_mineral_homeostasis1.65832575
29MP0005409_darkened_coat_color1.58838804
30MP0001764_abnormal_homeostasis1.54954826
31MP0008875_abnormal_xenobiotic_pharmacok1.54714902
32MP0000490_abnormal_crypts_of1.54232441
33MP0010352_gastrointestinal_tract_polyps1.53267789
34MP0001188_hyperpigmentation1.47709860
35MP0005670_abnormal_white_adipose1.46074828
36MP0000477_abnormal_intestine_morphology1.42729841
37MP0001873_stomach_inflammation1.36856696
38MP0005395_other_phenotype1.31020070
39MP0001501_abnormal_sleep_pattern1.26921061
40MP0005166_decreased_susceptibility_to1.25840470
41MP0003806_abnormal_nucleotide_metabolis1.25766819
42MP0001663_abnormal_digestive_system1.24666893
43MP0002136_abnormal_kidney_physiology1.23752864
44MP0002822_catalepsy1.21521391
45MP0002118_abnormal_lipid_homeostasis1.15330701
46MP0000230_abnormal_systemic_arterial1.11006379
47MP0008872_abnormal_physiological_respon1.09410113
48MP0001756_abnormal_urination1.09065262
49MP0000538_abnormal_urinary_bladder1.08856121
50MP0004782_abnormal_surfactant_physiolog1.01544635
51MP0005410_abnormal_fertilization0.95909177
52MP0005381_digestive/alimentary_phenotyp0.94303904
53MP0005448_abnormal_energy_balance0.92802834
54MP0001485_abnormal_pinna_reflex0.92415315
55MP0002796_impaired_skin_barrier0.89972444
56MP0005319_abnormal_enzyme/_coenzyme0.89431546
57MP0002098_abnormal_vibrissa_morphology0.85575172
58MP0000465_gastrointestinal_hemorrhage0.85443824
59MP0003693_abnormal_embryo_hatching0.85117599
60MP0010678_abnormal_skin_adnexa0.83778237
61MP0004270_analgesia0.83645650
62MP0005535_abnormal_body_temperature0.78947284
63MP0000609_abnormal_liver_physiology0.76642767
64MP0003195_calcinosis0.76547420
65MP0009642_abnormal_blood_homeostasis0.70264395
66MP0003953_abnormal_hormone_level0.69325819
67MP0008004_abnormal_stomach_pH0.68832071
68MP0002277_abnormal_respiratory_mucosa0.66469423
69MP0009115_abnormal_fat_cell0.65717004
70MP0001845_abnormal_inflammatory_respons0.65330195
71MP0008789_abnormal_olfactory_epithelium0.62591799
72MP0000462_abnormal_digestive_system0.61977847
73MP0009785_altered_susceptibility_to0.58476207
74MP0002971_abnormal_brown_adipose0.57891756
75MP0005584_abnormal_enzyme/coenzyme_acti0.57260592
76MP0005501_abnormal_skin_physiology0.57038759
77MP0000015_abnormal_ear_pigmentation0.56834569
78MP0002078_abnormal_glucose_homeostasis0.56795667
79MP0005310_abnormal_salivary_gland0.56532893
80MP0002132_abnormal_respiratory_system0.56110865
81MP0008469_abnormal_protein_level0.53901027
82MP0000566_synostosis0.53660646
83MP0004858_abnormal_nervous_system0.53203921
84MP0000427_abnormal_hair_cycle0.52985381
85MP0003724_increased_susceptibility_to0.52332268
86MP0001881_abnormal_mammary_gland0.52189350
87MP0005174_abnormal_tail_pigmentation0.50382280
88MP0006082_CNS_inflammation0.45420821
89MP0001986_abnormal_taste_sensitivity0.43644342
90MP0002396_abnormal_hematopoietic_system0.43214594
91MP0009333_abnormal_splenocyte_physiolog0.42669571
92MP0001929_abnormal_gametogenesis0.42560088
93MP0000470_abnormal_stomach_morphology0.42467290
94MP0005334_abnormal_fat_pad0.40914188
95MP0008775_abnormal_heart_ventricle0.40609765
96MP0000681_abnormal_thyroid_gland0.40123703
97MP0004215_abnormal_myocardial_fiber0.39479347
98MP0004484_altered_response_of0.39353176
99MP0005394_taste/olfaction_phenotype0.38798378
100MP0005499_abnormal_olfactory_system0.38798378

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.59601189
2Malnutrition (HP:0004395)6.48453024
3Abnormality of proline metabolism (HP:0010907)6.00474571
4Hydroxyprolinuria (HP:0003080)6.00474571
5Hyperactive renin-angiotensin system (HP:0000841)5.64340993
6Decreased circulating renin level (HP:0003351)5.24353347
7Abnormality of the vitamin B12 metabolism (HP:0004341)5.00997323
8Abnormality of vitamin B metabolism (HP:0004340)4.73864350
9Ileus (HP:0002595)4.59017982
10Fat malabsorption (HP:0002630)4.52105351
11Chronic diarrhea (HP:0002028)4.50753942
12Abnormality of renin-angiotensin system (HP:0000847)4.38032782
13Metabolic alkalosis (HP:0200114)3.92502902
14Abnormality of vitamin metabolism (HP:0100508)3.75170009
15Congenital sensorineural hearing impairment (HP:0008527)3.74748001
16Hypobetalipoproteinemia (HP:0003563)3.71077750
17Glycosuria (HP:0003076)3.56911139
18Abnormality of urine glucose concentration (HP:0011016)3.56911139
19Proximal tubulopathy (HP:0000114)3.52866359
20Confusion (HP:0001289)3.51796103
21Alkalosis (HP:0001948)3.48964211
22Widely patent fontanelles and sutures (HP:0004492)3.45990195
23Hyperglycinuria (HP:0003108)3.40433156
24Abnormal ciliary motility (HP:0012262)3.31455103
25Acanthocytosis (HP:0001927)3.30918171
26Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29604263
27Steatorrhea (HP:0002570)3.24547939
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18906971
29Abnormal respiratory motile cilium physiology (HP:0012261)3.14939993
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.14812672
31Absent/shortened dynein arms (HP:0200106)3.14812672
32Nausea (HP:0002018)3.13916982
33Pigmentary retinal degeneration (HP:0001146)3.05710380
34Abnormality of glycine metabolism (HP:0010895)3.03749175
35Abnormality of serine family amino acid metabolism (HP:0010894)3.03749175
36Abnormal respiratory epithelium morphology (HP:0012253)3.02172989
37Abnormal respiratory motile cilium morphology (HP:0005938)3.02172989
38Hyperaldosteronism (HP:0000859)2.97752890
39Posterior subcapsular cataract (HP:0007787)2.96602035
40Rhinitis (HP:0012384)2.94622291
41Chronic bronchitis (HP:0004469)2.70416226
42Nephrolithiasis (HP:0000787)2.55401766
43Abdominal distention (HP:0003270)2.54433745
44Intrahepatic cholestasis (HP:0001406)2.53154421
45Abnormality of chloride homeostasis (HP:0011422)2.52370539
46Abnormality of magnesium homeostasis (HP:0004921)2.51045047
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50906071
48Megaloblastic anemia (HP:0001889)2.49101517
49Increased purine levels (HP:0004368)2.48681797
50Hyperuricemia (HP:0002149)2.48681797
51Bronchiectasis (HP:0002110)2.48180402
52Hyperphosphatemia (HP:0002905)2.42268985
53Systemic lupus erythematosus (HP:0002725)2.41528392
54Male infertility (HP:0003251)2.41180226
55Potter facies (HP:0002009)2.40700618
56Facial shape deformation (HP:0011334)2.40700618
57Hyperammonemia (HP:0001987)2.38872867
58Hypokalemia (HP:0002900)2.38439605
59Hypophosphatemia (HP:0002148)2.36759495
60Hypophosphatemic rickets (HP:0004912)2.36006083
61Abnormal urine phosphate concentration (HP:0012599)2.33248574
62Dicarboxylic aciduria (HP:0003215)2.33033080
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33033080
64Nasal polyposis (HP:0100582)2.29673584
65Abnormality of potassium homeostasis (HP:0011042)2.27644711
66Abnormality of small intestinal villus morphology (HP:0011472)2.27628503
67Villous atrophy (HP:0011473)2.27628503
68Flat acetabular roof (HP:0003180)2.26495681
69Abnormality of the nasal mucosa (HP:0000433)2.25213213
70Metabolic acidosis (HP:0001942)2.24142068
71Subcapsular cataract (HP:0000523)2.20503332
72Wide cranial sutures (HP:0010537)2.19098569
73Hyponatremia (HP:0002902)2.18377017
74Abnormal biliary tract morphology (HP:0012440)2.17265714
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.16451449
76Hypotension (HP:0002615)2.15622438
77Pancreatitis (HP:0001733)2.14786616
78Infertility (HP:0000789)2.14245359
79Abnormality of purine metabolism (HP:0004352)2.13812006
80Generalized aminoaciduria (HP:0002909)2.10222523
81Dehydration (HP:0001944)2.07355298
82Xanthomatosis (HP:0000991)2.07088530
83Conjugated hyperbilirubinemia (HP:0002908)2.06066156
84Hyperphosphaturia (HP:0003109)2.04696414
85Hyperkalemia (HP:0002153)2.03506234
86Abnormality of sulfur amino acid metabolism (HP:0004339)1.99149833
87Enlarged epiphyses (HP:0010580)1.99051598
88Biliary tract neoplasm (HP:0100574)1.97790329
89Hemorrhage of the eye (HP:0011885)1.96768326
90Metaphyseal irregularity (HP:0003025)1.95446846
91Focal segmental glomerulosclerosis (HP:0000097)1.95048016
92Abnormality of nucleobase metabolism (HP:0010932)1.92909831
93Methylmalonic aciduria (HP:0012120)1.90222721
94Increased circulating renin level (HP:0000848)1.88864860
95Chronic sinusitis (HP:0011109)1.88018352
96Cerebral palsy (HP:0100021)1.84267049
97Hyperparathyroidism (HP:0000843)1.82353009
98Renal tubular acidosis (HP:0001947)1.82063555
99Thin bony cortex (HP:0002753)1.82001919
100Adrenal overactivity (HP:0002717)1.81667095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.29317680
2MST1R4.38387143
3MST43.76474654
4EPHA23.60907890
5STK392.94135557
6PRKG22.93326551
7FRK2.78361316
8OXSR12.71770292
9ERN12.45006317
10STK242.43043636
11MET2.23897285
12TNIK2.14923321
13RIPK12.08274151
14PIK3CA1.98401272
15LMTK21.69357435
16CDK191.66395114
17PDK21.58164305
18MAP3K101.45541288
19TAOK31.40491071
20MAP3K121.37704362
21MAP3K21.33671320
22NEK61.27829968
23GRK11.20377352
24INSRR1.14916222
25TESK21.12017484
26MATK1.10297331
27WNK41.09997276
28MAPK151.07466208
29PRKCI1.04852799
30BMPR20.96051008
31MAP3K130.95083628
32ADRBK20.92022804
33RIPK40.90553692
34EPHB20.89891017
35BMPR1B0.86552743
36FER0.86439509
37MYLK0.86333772
38EPHA30.84045397
39GRK60.83585701
40PTK60.81540254
41NLK0.80981529
42PRKAA20.80355625
43PDPK10.73703621
44TESK10.73657613
45MAP3K10.72184564
46TRIM280.71861244
47PRKCZ0.68940633
48MAPKAPK30.68214596
49DDR20.68208401
50ERBB20.67885056
51PRKCA0.67745446
52TTK0.67474086
53PDK10.65461280
54EPHA40.63725799
55AKT30.62406894
56TYK20.61830802
57PIM10.60028284
58EPHB10.59455081
59STK30.58840394
60PRKACG0.58407854
61MAP2K60.57599938
62MAP2K20.54863697
63NUAK10.52971124
64MAP4K10.50633172
65NME10.47078420
66FGFR30.46903951
67MAPK110.45877568
68ABL20.45797241
69CDK90.44248611
70CAMK2D0.42797184
71IRAK10.42201790
72CDC42BPA0.41943383
73TLK10.41111865
74PRKCQ0.40943369
75MAP4K20.40728183
76MELK0.40362619
77CSF1R0.39750288
78ARAF0.37310580
79PRKACA0.36895728
80CAMK2A0.36419449
81PRKG10.35942175
82PRKCE0.34760410
83TEC0.34326544
84SRC0.34249653
85TAOK10.33682081
86KSR20.32362434
87BRAF0.30790635
88BRSK20.29194467
89PRKCD0.28865063
90DYRK1B0.28384242
91EIF2AK30.26610362
92MAP3K80.24586407
93IGF1R0.23507692
94CSNK1A10.22827864
95MAP3K90.22387831
96CASK0.22214199
97PINK10.18968776
98MAP3K50.18899229
99LYN0.18468552
100DAPK20.17886425

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.48704254
2Fat digestion and absorption_Homo sapiens_hsa049754.25666694
3Vitamin digestion and absorption_Homo sapiens_hsa049773.88785573
4Renin-angiotensin system_Homo sapiens_hsa046143.36023850
5Caffeine metabolism_Homo sapiens_hsa002323.11921485
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.76319581
7Mineral absorption_Homo sapiens_hsa049782.60554334
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.46176919
9Protein digestion and absorption_Homo sapiens_hsa049742.41494998
10Histidine metabolism_Homo sapiens_hsa003402.39419293
11Sulfur metabolism_Homo sapiens_hsa009202.25294108
12Starch and sucrose metabolism_Homo sapiens_hsa005002.24981418
13Linoleic acid metabolism_Homo sapiens_hsa005912.21208984
14Chemical carcinogenesis_Homo sapiens_hsa052042.20246549
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17278278
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12804055
17Retinol metabolism_Homo sapiens_hsa008302.08166107
18Arginine biosynthesis_Homo sapiens_hsa002202.03591411
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03146663
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99737123
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97110865
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.96578344
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.83763587
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76052133
25Bile secretion_Homo sapiens_hsa049761.64276250
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.63884897
27Fructose and mannose metabolism_Homo sapiens_hsa000511.54319718
28Arachidonic acid metabolism_Homo sapiens_hsa005901.50598605
29PPAR signaling pathway_Homo sapiens_hsa033201.50289815
30Galactose metabolism_Homo sapiens_hsa000521.45534256
31Glycerolipid metabolism_Homo sapiens_hsa005611.36920968
32Arginine and proline metabolism_Homo sapiens_hsa003301.34368295
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34113670
34Pancreatic secretion_Homo sapiens_hsa049721.32437533
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26993220
36Fatty acid degradation_Homo sapiens_hsa000711.26719793
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25353399
38Asthma_Homo sapiens_hsa053101.22564413
39Tryptophan metabolism_Homo sapiens_hsa003801.22220961
40Ether lipid metabolism_Homo sapiens_hsa005651.20930164
41Nitrogen metabolism_Homo sapiens_hsa009101.18605360
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17848471
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.14994373
44Glutathione metabolism_Homo sapiens_hsa004800.95234086
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92777408
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83740483
47Allograft rejection_Homo sapiens_hsa053300.77859917
48Phenylalanine metabolism_Homo sapiens_hsa003600.74454667
49Sphingolipid metabolism_Homo sapiens_hsa006000.73657042
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73339766
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73018794
52Autoimmune thyroid disease_Homo sapiens_hsa053200.71448792
53Graft-versus-host disease_Homo sapiens_hsa053320.71132941
54Peroxisome_Homo sapiens_hsa041460.68716065
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.68410010
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68203506
57Type I diabetes mellitus_Homo sapiens_hsa049400.66264167
58ABC transporters_Homo sapiens_hsa020100.64229537
59Butanoate metabolism_Homo sapiens_hsa006500.63264683
60Propanoate metabolism_Homo sapiens_hsa006400.53420607
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52419751
62Folate biosynthesis_Homo sapiens_hsa007900.52001591
63Ovarian steroidogenesis_Homo sapiens_hsa049130.48789579
64Fatty acid metabolism_Homo sapiens_hsa012120.48097392
65Tyrosine metabolism_Homo sapiens_hsa003500.47679807
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.40980930
67Staphylococcus aureus infection_Homo sapiens_hsa051500.38372092
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38187871
69Metabolic pathways_Homo sapiens_hsa011000.35985308
70Fatty acid biosynthesis_Homo sapiens_hsa000610.34638321
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34037483
72Fatty acid elongation_Homo sapiens_hsa000620.31274089
73Renin secretion_Homo sapiens_hsa049240.28939633
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28915077
75Insulin secretion_Homo sapiens_hsa049110.28695233
76Tight junction_Homo sapiens_hsa045300.27129100
77Serotonergic synapse_Homo sapiens_hsa047260.24899990
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24123411
79beta-Alanine metabolism_Homo sapiens_hsa004100.23359258
80Antigen processing and presentation_Homo sapiens_hsa046120.17158311
81Insulin resistance_Homo sapiens_hsa049310.16139972
82Sulfur relay system_Homo sapiens_hsa041220.16073335
83Thyroid hormone synthesis_Homo sapiens_hsa049180.15258238
84Pyruvate metabolism_Homo sapiens_hsa006200.13762356
85Cocaine addiction_Homo sapiens_hsa050300.09683061
86Taste transduction_Homo sapiens_hsa047420.08828265
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.07663583
88Salivary secretion_Homo sapiens_hsa049700.06723314
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06484551
90Hematopoietic cell lineage_Homo sapiens_hsa046400.04295330
91Hepatitis C_Homo sapiens_hsa051600.03151431
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.01101231
93Phototransduction_Homo sapiens_hsa047440.00889191
94Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0331446
95Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0323286
96Collecting duct acid secretion_Homo sapiens_hsa04966-0.0299149
97SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0265593
98Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0224235
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0075083
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0035742

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