HHLA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10004004
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53713742
3ATP synthesis coupled proton transport (GO:0015986)4.47656333
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47656333
5protein complex biogenesis (GO:0070271)4.46913459
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.26980069
7mitochondrial respiratory chain complex assembly (GO:0033108)4.19161259
8chaperone-mediated protein transport (GO:0072321)4.14231567
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.12102493
10NADH dehydrogenase complex assembly (GO:0010257)4.12102493
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12102493
12regulation of mitochondrial translation (GO:0070129)4.08350999
13proteasome assembly (GO:0043248)3.99673400
14respiratory electron transport chain (GO:0022904)3.86810245
15electron transport chain (GO:0022900)3.83010840
16respiratory chain complex IV assembly (GO:0008535)3.76163602
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.73217547
18rRNA modification (GO:0000154)3.68660778
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62588177
20cytochrome complex assembly (GO:0017004)3.58419177
21peptidyl-histidine modification (GO:0018202)3.41604539
22water-soluble vitamin biosynthetic process (GO:0042364)3.37128302
23rRNA methylation (GO:0031167)3.30512294
24protein neddylation (GO:0045116)3.26709403
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25511326
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.25511326
27chromatin remodeling at centromere (GO:0031055)3.22799898
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.22090824
29termination of RNA polymerase III transcription (GO:0006386)3.22090824
30CENP-A containing nucleosome assembly (GO:0034080)3.19561673
31cullin deneddylation (GO:0010388)3.18600980
32pseudouridine synthesis (GO:0001522)3.18401207
33DNA deamination (GO:0045006)3.16067704
34cellular ketone body metabolic process (GO:0046950)3.13584121
35DNA double-strand break processing (GO:0000729)3.07658837
36nonmotile primary cilium assembly (GO:0035058)3.07381490
37platelet dense granule organization (GO:0060155)3.05153769
38synapsis (GO:0007129)3.03125371
39resolution of meiotic recombination intermediates (GO:0000712)3.02374369
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01135741
41maturation of 5.8S rRNA (GO:0000460)3.00260590
42mannosylation (GO:0097502)2.97596818
43protein targeting to mitochondrion (GO:0006626)2.92286415
44preassembly of GPI anchor in ER membrane (GO:0016254)2.92222179
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91799946
46ribosomal small subunit assembly (GO:0000028)2.88662572
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87116200
48protein K6-linked ubiquitination (GO:0085020)2.86358476
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83879134
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83879134
51protein deneddylation (GO:0000338)2.83778933
52branched-chain amino acid catabolic process (GO:0009083)2.83479189
53histone exchange (GO:0043486)2.82103596
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80834742
55regulation of mitotic spindle checkpoint (GO:1903504)2.80834742
56piRNA metabolic process (GO:0034587)2.79383611
57ATP biosynthetic process (GO:0006754)2.79151387
58ketone body metabolic process (GO:1902224)2.78952564
59aldehyde catabolic process (GO:0046185)2.78319131
60hydrogen ion transmembrane transport (GO:1902600)2.76700228
61regulation of cellular amino acid metabolic process (GO:0006521)2.75543461
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.75533987
63intracellular protein transmembrane import (GO:0044743)2.74606991
64establishment of protein localization to mitochondrion (GO:0072655)2.74170609
65negative regulation of ligase activity (GO:0051352)2.72322732
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72322732
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71712913
68oxidative phosphorylation (GO:0006119)2.71675818
697-methylguanosine mRNA capping (GO:0006370)2.69610431
70protein localization to mitochondrion (GO:0070585)2.68803285
71DNA replication checkpoint (GO:0000076)2.65933300
72regulation of helicase activity (GO:0051095)2.65414502
73regulation of meiosis I (GO:0060631)2.65246703
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64783252
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62939784
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62920983
77RNA capping (GO:0036260)2.61913050
787-methylguanosine RNA capping (GO:0009452)2.61913050
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61701217
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.61168591
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57994721
82tRNA processing (GO:0008033)2.56994955
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56727998
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56727998
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56727998
86protein-cofactor linkage (GO:0018065)2.56458390
87response to pheromone (GO:0019236)2.55631281
88spliceosomal snRNP assembly (GO:0000387)2.55501175
89C-terminal protein lipidation (GO:0006501)2.54873395
90proton transport (GO:0015992)2.54813127
91anterograde synaptic vesicle transport (GO:0048490)2.54769803
92positive regulation of ligase activity (GO:0051351)2.52706510
93recombinational repair (GO:0000725)2.52422694
94intraciliary transport (GO:0042073)2.52311513
95kinetochore assembly (GO:0051382)2.52194353
96regulation of cilium movement (GO:0003352)2.50827151
97epithelial cilium movement (GO:0003351)2.50718598
98iron-sulfur cluster assembly (GO:0016226)2.49355977
99metallo-sulfur cluster assembly (GO:0031163)2.49355977
100hydrogen transport (GO:0006818)2.48886273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77437184
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.13198491
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.81228830
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57761298
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24120089
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21103458
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97817720
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.94378760
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68870732
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60107909
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59415459
12ZNF274_21170338_ChIP-Seq_K562_Hela2.57139586
13ELK1_19687146_ChIP-ChIP_HELA_Human2.47583692
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.38777841
15VDR_23849224_ChIP-Seq_CD4+_Human2.36822130
16IGF1R_20145208_ChIP-Seq_DFB_Human2.28506934
17* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18830091
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.15069159
19FOXP3_21729870_ChIP-Seq_TREG_Human2.13361077
20VDR_22108803_ChIP-Seq_LS180_Human2.04721747
21EWS_26573619_Chip-Seq_HEK293_Human1.93222425
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92652852
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91471866
24MYC_18940864_ChIP-ChIP_HL60_Human1.87659439
25FUS_26573619_Chip-Seq_HEK293_Human1.87001169
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75443052
27GBX2_23144817_ChIP-Seq_PC3_Human1.73564336
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70944721
29E2F7_22180533_ChIP-Seq_HELA_Human1.67761197
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67048602
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66957933
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66670589
33TTF2_22483619_ChIP-Seq_HELA_Human1.63374570
34DCP1A_22483619_ChIP-Seq_HELA_Human1.62661249
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61770783
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60447890
37GABP_19822575_ChIP-Seq_HepG2_Human1.59494803
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57772171
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47724929
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45863958
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.42789321
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40878641
43* TP53_22573176_ChIP-Seq_HFKS_Human1.40293563
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38481006
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36771466
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.36312177
47* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35845544
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35429150
49* P300_19829295_ChIP-Seq_ESCs_Human1.33925076
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32646500
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.32641068
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29241743
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28705235
54* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26883357
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26617127
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25082644
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24649932
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24435591
59* XRN2_22483619_ChIP-Seq_HELA_Human1.22276330
60TAF15_26573619_Chip-Seq_HEK293_Human1.22021436
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.18392689
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17092775
63* NANOG_19829295_ChIP-Seq_ESCs_Human1.16629387
64* SOX2_19829295_ChIP-Seq_ESCs_Human1.16629387
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13330087
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10937973
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10763072
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.09405143
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08959522
70IRF1_19129219_ChIP-ChIP_H3396_Human1.07390797
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.05329126
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04550496
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04108784
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01997482
75HTT_18923047_ChIP-ChIP_STHdh_Human1.00123736
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99784650
77* FOXA1_25329375_ChIP-Seq_VCAP_Human0.97101531
78* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97101531
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96209932
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95017458
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94535988
82KDM5A_27292631_Chip-Seq_BREAST_Human0.92895882
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92894862
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92105919
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.92084937
86CBP_20019798_ChIP-Seq_JUKART_Human0.92055420
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92055420
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92018236
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90203996
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89991360
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89758512
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.87003806
93AR_20517297_ChIP-Seq_VCAP_Human0.85595098
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.85513077
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85466335
96HOXB7_26014856_ChIP-Seq_BT474_Human0.85307765
97AR_25329375_ChIP-Seq_VCAP_Human0.84953123
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84768656
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84468792
100NCOR_22424771_ChIP-Seq_293T_Human0.84448000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.35369118
2MP0006292_abnormal_olfactory_placode3.30072664
3MP0008058_abnormal_DNA_repair2.84921399
4MP0002938_white_spotting2.39142993
5MP0000372_irregular_coat_pigmentation2.34756807
6MP0001984_abnormal_olfaction2.14416573
7MP0003195_calcinosis2.11438168
8MP0009697_abnormal_copulation2.07563160
9MP0003718_maternal_effect1.98925478
10MP0005551_abnormal_eye_electrophysiolog1.98066308
11MP0003136_yellow_coat_color1.96365835
12MP0003122_maternal_imprinting1.94934264
13MP0003693_abnormal_embryo_hatching1.93583003
14MP0005379_endocrine/exocrine_gland_phen1.84816239
15MP0006072_abnormal_retinal_apoptosis1.83916272
16MP0002837_dystrophic_cardiac_calcinosis1.81927758
17MP0003186_abnormal_redox_activity1.79177739
18MP0001529_abnormal_vocalization1.79150362
19MP0003011_delayed_dark_adaptation1.78683907
20MP0002254_reproductive_system_inflammat1.78177383
21MP0005646_abnormal_pituitary_gland1.75727412
22MP0008789_abnormal_olfactory_epithelium1.74334189
23MP0006036_abnormal_mitochondrial_physio1.69644631
24MP0004147_increased_porphyrin_level1.69439187
25MP0002822_catalepsy1.67952176
26MP0004957_abnormal_blastocyst_morpholog1.67783580
27MP0005499_abnormal_olfactory_system1.61837183
28MP0005394_taste/olfaction_phenotype1.61837183
29MP0003786_premature_aging1.61575535
30MP0010094_abnormal_chromosome_stability1.55965455
31MP0003787_abnormal_imprinting1.54689146
32MP0002163_abnormal_gland_morphology1.53614819
33MP0005253_abnormal_eye_physiology1.51747326
34MP0003121_genomic_imprinting1.49208419
35MP0001968_abnormal_touch/_nociception1.48939587
36MP0006035_abnormal_mitochondrial_morpho1.45633557
37MP0001293_anophthalmia1.43888806
38MP0002736_abnormal_nociception_after1.43018615
39MP0009046_muscle_twitch1.41227377
40MP0004142_abnormal_muscle_tone1.41114290
41MP0005410_abnormal_fertilization1.38493986
42MP0003806_abnormal_nucleotide_metabolis1.37985783
43MP0001764_abnormal_homeostasis1.37858777
44MP0001485_abnormal_pinna_reflex1.36668275
45MP0008995_early_reproductive_senescence1.36528969
46MP0004133_heterotaxia1.35591589
47MP0002090_abnormal_vision1.34888119
48MP0002102_abnormal_ear_morphology1.34764636
49MP0002210_abnormal_sex_determination1.34160445
50MP0003111_abnormal_nucleus_morphology1.34057216
51MP0008875_abnormal_xenobiotic_pharmacok1.33099337
52MP0001929_abnormal_gametogenesis1.30973175
53MP0001905_abnormal_dopamine_level1.29154724
54MP0000631_abnormal_neuroendocrine_gland1.28970351
55MP0008872_abnormal_physiological_respon1.25316972
56MP0003890_abnormal_embryonic-extraembry1.24310079
57MP0009745_abnormal_behavioral_response1.22828689
58MP0008932_abnormal_embryonic_tissue1.21145777
59MP0005084_abnormal_gallbladder_morpholo1.20384077
60MP0001188_hyperpigmentation1.19152201
61MP0005075_abnormal_melanosome_morpholog1.17700648
62MP0009379_abnormal_foot_pigmentation1.15999178
63MP0003698_abnormal_male_reproductive1.15022695
64MP0005645_abnormal_hypothalamus_physiol1.14322626
65MP0000653_abnormal_sex_gland1.14138700
66MP0001486_abnormal_startle_reflex1.11524073
67MP0001145_abnormal_male_reproductive1.10533513
68MP0003880_abnormal_central_pattern1.10478348
69MP0005332_abnormal_amino_acid1.09319420
70MP0005367_renal/urinary_system_phenotyp1.09277946
71MP0000516_abnormal_urinary_system1.09277946
72MP0002272_abnormal_nervous_system1.08944448
73MP0002160_abnormal_reproductive_system1.08604193
74MP0005389_reproductive_system_phenotype1.07218096
75MP0008007_abnormal_cellular_replicative1.04621342
76MP0001919_abnormal_reproductive_system1.04138570
77MP0002638_abnormal_pupillary_reflex1.04083882
78MP0006276_abnormal_autonomic_nervous1.02982595
79MP0002095_abnormal_skin_pigmentation1.01446418
80MP0000647_abnormal_sebaceous_gland1.01021827
81MP0004742_abnormal_vestibular_system1.00931018
82MP0000427_abnormal_hair_cycle1.00280003
83MP0002735_abnormal_chemical_nociception0.99504142
84MP0003077_abnormal_cell_cycle0.92837441
85MP0005174_abnormal_tail_pigmentation0.91624307
86MP0002557_abnormal_social/conspecific_i0.90409233
87MP0003119_abnormal_digestive_system0.89051977
88MP0004885_abnormal_endolymph0.89036561
89MP0001986_abnormal_taste_sensitivity0.88835503
90MP0006054_spinal_hemorrhage0.88409429
91MP0001324_abnormal_eye_pigmentation0.83086859
92MP0001963_abnormal_hearing_physiology0.82972637
93MP0002064_seizures0.80633931
94MP0005195_abnormal_posterior_eye0.80601049
95MP0002234_abnormal_pharynx_morphology0.80333956
96MP0001727_abnormal_embryo_implantation0.80305001
97MP0002233_abnormal_nose_morphology0.79272013
98MP0001970_abnormal_pain_threshold0.79005023
99MP0005391_vision/eye_phenotype0.78530714
100MP0003941_abnormal_skin_development0.78346822

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.35253055
2Mitochondrial inheritance (HP:0001427)3.95825895
3Acute encephalopathy (HP:0006846)3.93969729
4Abnormal mitochondria in muscle tissue (HP:0008316)3.85710357
5Progressive macrocephaly (HP:0004481)3.73991201
6Increased CSF lactate (HP:0002490)3.62500835
7Increased hepatocellular lipid droplets (HP:0006565)3.36210018
8Hepatocellular necrosis (HP:0001404)3.31734521
9Hepatic necrosis (HP:0002605)3.22980161
10Lipid accumulation in hepatocytes (HP:0006561)3.20140320
11True hermaphroditism (HP:0010459)3.19379664
12Pancreatic fibrosis (HP:0100732)3.13602253
13Medial flaring of the eyebrow (HP:0010747)3.12832890
14Renal Fanconi syndrome (HP:0001994)3.03376434
15Pancreatic cysts (HP:0001737)3.01966816
16Cerebral edema (HP:0002181)2.99290474
17Abnormality of the labia minora (HP:0012880)2.99181324
18Methylmalonic acidemia (HP:0002912)2.88260073
19Hyperglycinemia (HP:0002154)2.87381097
20Gait imbalance (HP:0002141)2.75853604
21Congenital primary aphakia (HP:0007707)2.75495715
22Colon cancer (HP:0003003)2.73919274
233-Methylglutaconic aciduria (HP:0003535)2.71369785
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69568484
25Molar tooth sign on MRI (HP:0002419)2.61063667
26Abnormality of midbrain morphology (HP:0002418)2.61063667
27Nephrogenic diabetes insipidus (HP:0009806)2.58372784
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53527992
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53527992
30Hyperglycinuria (HP:0003108)2.52565171
31Methylmalonic aciduria (HP:0012120)2.51507391
32Increased serum lactate (HP:0002151)2.50049012
33Lactic acidosis (HP:0003128)2.39595481
34Abnormality of glycine metabolism (HP:0010895)2.38034493
35Abnormality of serine family amino acid metabolism (HP:0010894)2.38034493
36Abnormal glycosylation (HP:0012345)2.33649596
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33649596
38Abnormal protein N-linked glycosylation (HP:0012347)2.33649596
39Abnormal protein glycosylation (HP:0012346)2.33649596
40Type I transferrin isoform profile (HP:0003642)2.31737729
41Respiratory failure (HP:0002878)2.28498585
42Nephronophthisis (HP:0000090)2.28446297
43Sclerocornea (HP:0000647)2.26605410
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22127204
45Reticulocytopenia (HP:0001896)2.20580988
46Vaginal atresia (HP:0000148)2.19549323
47Genital tract atresia (HP:0001827)2.18985807
48Degeneration of anterior horn cells (HP:0002398)2.17560728
49Abnormality of the anterior horn cell (HP:0006802)2.17560728
50Lethargy (HP:0001254)2.16625616
51Increased intramyocellular lipid droplets (HP:0012240)2.13554693
52Male pseudohermaphroditism (HP:0000037)2.02948435
53Optic disc pallor (HP:0000543)2.02759279
54Glycosuria (HP:0003076)1.98863650
55Abnormality of urine glucose concentration (HP:0011016)1.98863650
56Abnormality of renal resorption (HP:0011038)1.98558189
57Leukodystrophy (HP:0002415)1.96369394
58Abnormal number of erythroid precursors (HP:0012131)1.94580767
59Exertional dyspnea (HP:0002875)1.94109602
60Exercise intolerance (HP:0003546)1.93473180
61Hypomagnesemia (HP:0002917)1.91390613
62Generalized aminoaciduria (HP:0002909)1.89568957
63Abolished electroretinogram (ERG) (HP:0000550)1.89151907
64Abnormality of serum amino acid levels (HP:0003112)1.88775475
65Meckel diverticulum (HP:0002245)1.88045164
66Poor coordination (HP:0002370)1.87824912
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.87379971
68Aplasia/Hypoplasia of the uvula (HP:0010293)1.86058712
69Abnormality of the renal medulla (HP:0100957)1.81672031
70Abnormality of the ileum (HP:0001549)1.81241185
71Abnormality of the renal cortex (HP:0011035)1.78990607
72Polydipsia (HP:0001959)1.78730176
73Abnormal drinking behavior (HP:0030082)1.78730176
74Sensory axonal neuropathy (HP:0003390)1.77726301
75Intestinal atresia (HP:0011100)1.77725370
76Absent thumb (HP:0009777)1.77430861
77Abnormality of cells of the erythroid lineage (HP:0012130)1.77065515
78Aplasia/hypoplasia of the uterus (HP:0008684)1.76850369
79Progressive inability to walk (HP:0002505)1.76355498
80Septo-optic dysplasia (HP:0100842)1.76351432
81Aplastic anemia (HP:0001915)1.76175949
82Cystic liver disease (HP:0006706)1.75651847
83Abnormal biliary tract physiology (HP:0012439)1.75324809
84Bile duct proliferation (HP:0001408)1.75324809
85Abnormality of vitamin B metabolism (HP:0004340)1.74960096
86Increased muscle lipid content (HP:0009058)1.74546322
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73852008
88Abnormality of alanine metabolism (HP:0010916)1.73852008
89Hyperalaninemia (HP:0003348)1.73852008
90Pendular nystagmus (HP:0012043)1.73173472
91Anencephaly (HP:0002323)1.72352681
92CNS demyelination (HP:0007305)1.72169813
93Respiratory difficulties (HP:0002880)1.69905676
94Abnormal lung lobation (HP:0002101)1.66638019
95Adrenal hypoplasia (HP:0000835)1.66517771
96Cerebral hypomyelination (HP:0006808)1.66395673
97Abnormality of chromosome stability (HP:0003220)1.66316367
98Abnormality of methionine metabolism (HP:0010901)1.63516898
99Chromsome breakage (HP:0040012)1.63501243
100Dicarboxylic aciduria (HP:0003215)1.62876754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.98137666
2MST43.37735713
3FRK2.84742686
4ZAK2.76433467
5WNK32.75761924
6DYRK32.72774779
7BRSK22.51761158
8BUB12.49045009
9MAP4K22.46226921
10NUAK12.32899421
11TRIM282.27093399
12WEE12.24122002
13STK162.13817081
14TNIK2.04176241
15BMPR1B2.00107656
16PBK1.98672825
17PLK41.92322016
18CDC71.83891278
19TAF11.81594647
20WNK41.78834731
21EIF2AK31.74699813
22BCKDK1.73776436
23VRK11.70449256
24BRSK11.68745902
25PLK31.55198930
26ACVR1B1.52059555
27PINK11.41415819
28ADRBK21.39110420
29GRK11.38247472
30MAP3K41.36991354
31MKNK21.36504443
32TTK1.31013691
33NME11.29576472
34CSNK1G11.29121659
35PLK11.28346186
36CSNK1G31.28012281
37DYRK21.27269438
38STK391.23753499
39PDK21.22968081
40MAP2K71.18134420
41CDK191.17676054
42CSNK1G21.16665059
43NEK11.16169996
44OXSR11.12885476
45MKNK11.07022869
46CSNK1A1L1.06554109
47INSRR1.03919908
48PLK21.01700184
49SRPK10.97842418
50EIF2AK10.87987086
51CASK0.81801054
52MAPK130.78996150
53PNCK0.77436979
54MAPKAPK50.75890229
55PAK30.73525420
56TLK10.72260776
57EIF2AK20.71065995
58ATR0.70078712
59ERBB30.69289113
60PRKCG0.69090111
61AURKA0.67497951
62STK30.65979497
63CHEK20.64646921
64MAP3K120.60428653
65PASK0.58790315
66NME20.55570098
67TSSK60.55024803
68PRKCE0.54673358
69CSNK2A10.54407116
70FGFR20.54363174
71STK38L0.53570232
72AURKB0.50758150
73RPS6KA50.47655196
74PRKCI0.46903413
75STK40.44263101
76CSNK2A20.44246545
77ATM0.42623194
78NEK20.41797487
79MAPKAPK30.40695238
80DAPK10.39936581
81PRKD30.38858085
82RPS6KA40.38413368
83TXK0.37778080
84LIMK10.37673896
85BCR0.36405868
86PHKG20.35527440
87PHKG10.35527440
88CHEK10.34916401
89CSNK1E0.34866806
90GRK50.33949799
91ABL20.31697772
92CSNK1A10.31643307
93PIM20.30997226
94FLT30.29951495
95ADRBK10.26807593
96CSNK1D0.26483654
97STK240.25930322
98CAMK2A0.23845730
99PRKACA0.23180882
100PRKACB0.21506153

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.48433165
2Proteasome_Homo sapiens_hsa030503.35009097
3Protein export_Homo sapiens_hsa030602.92363801
4Parkinsons disease_Homo sapiens_hsa050122.86783796
5Ribosome_Homo sapiens_hsa030102.63241863
6RNA polymerase_Homo sapiens_hsa030202.56570655
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54368404
8Mismatch repair_Homo sapiens_hsa034302.36068672
9Homologous recombination_Homo sapiens_hsa034402.31219854
10Huntingtons disease_Homo sapiens_hsa050162.16162580
11Basal transcription factors_Homo sapiens_hsa030222.05642087
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03113874
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98076290
14Propanoate metabolism_Homo sapiens_hsa006401.90430072
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90318691
16Alzheimers disease_Homo sapiens_hsa050101.84366610
17Fatty acid elongation_Homo sapiens_hsa000621.79142719
18DNA replication_Homo sapiens_hsa030301.78524800
19One carbon pool by folate_Homo sapiens_hsa006701.76046099
20Fanconi anemia pathway_Homo sapiens_hsa034601.74143335
21Butanoate metabolism_Homo sapiens_hsa006501.71095950
22Selenocompound metabolism_Homo sapiens_hsa004501.66901082
23RNA degradation_Homo sapiens_hsa030181.64882265
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59406558
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49524084
26Base excision repair_Homo sapiens_hsa034101.48589826
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.48040896
28Non-homologous end-joining_Homo sapiens_hsa034501.46607039
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45836370
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45094208
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44565139
32Glutathione metabolism_Homo sapiens_hsa004801.44420649
33Nucleotide excision repair_Homo sapiens_hsa034201.38934935
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37278669
35RNA transport_Homo sapiens_hsa030131.31686202
36Folate biosynthesis_Homo sapiens_hsa007901.31510390
37Pyrimidine metabolism_Homo sapiens_hsa002401.28768080
38Phototransduction_Homo sapiens_hsa047441.28292478
39Regulation of autophagy_Homo sapiens_hsa041401.27148436
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.25704011
41Peroxisome_Homo sapiens_hsa041461.24860447
42Spliceosome_Homo sapiens_hsa030401.19070932
43Cardiac muscle contraction_Homo sapiens_hsa042601.17614937
44Vitamin B6 metabolism_Homo sapiens_hsa007501.12576401
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11416017
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.06026544
47Collecting duct acid secretion_Homo sapiens_hsa049661.05403590
48Sulfur metabolism_Homo sapiens_hsa009201.03648756
49Purine metabolism_Homo sapiens_hsa002301.03498915
50Steroid biosynthesis_Homo sapiens_hsa001001.00474770
51beta-Alanine metabolism_Homo sapiens_hsa004101.00301033
52Pyruvate metabolism_Homo sapiens_hsa006200.99175057
53Tryptophan metabolism_Homo sapiens_hsa003800.97707461
54Metabolic pathways_Homo sapiens_hsa011000.90649320
55Fatty acid metabolism_Homo sapiens_hsa012120.88755968
56Nicotine addiction_Homo sapiens_hsa050330.86972250
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83719417
58Sulfur relay system_Homo sapiens_hsa041220.83315081
59Chemical carcinogenesis_Homo sapiens_hsa052040.81094493
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80460931
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78088707
62Nitrogen metabolism_Homo sapiens_hsa009100.77789198
63Linoleic acid metabolism_Homo sapiens_hsa005910.77333540
64Olfactory transduction_Homo sapiens_hsa047400.74279287
65Retinol metabolism_Homo sapiens_hsa008300.71241444
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70032531
67Fatty acid degradation_Homo sapiens_hsa000710.68617676
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64628293
69Caffeine metabolism_Homo sapiens_hsa002320.64163689
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62038843
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61862666
72Cell cycle_Homo sapiens_hsa041100.61153007
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60404282
74Arginine and proline metabolism_Homo sapiens_hsa003300.59852128
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51987496
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.51776726
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51629332
78Carbon metabolism_Homo sapiens_hsa012000.50875000
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49895839
80Ether lipid metabolism_Homo sapiens_hsa005650.48390553
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47385481
82mRNA surveillance pathway_Homo sapiens_hsa030150.46891357
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44184455
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43772140
85Oocyte meiosis_Homo sapiens_hsa041140.42862425
86Arachidonic acid metabolism_Homo sapiens_hsa005900.41493150
87Taste transduction_Homo sapiens_hsa047420.40446233
88N-Glycan biosynthesis_Homo sapiens_hsa005100.40084678
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37151118
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36455782
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34776044
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33218263
93Fat digestion and absorption_Homo sapiens_hsa049750.32716809
94Basal cell carcinoma_Homo sapiens_hsa052170.30302646
95Morphine addiction_Homo sapiens_hsa050320.28522570
96Tyrosine metabolism_Homo sapiens_hsa003500.28210925
97Vitamin digestion and absorption_Homo sapiens_hsa049770.27925912
98Biosynthesis of amino acids_Homo sapiens_hsa012300.27917076
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27175691
100GABAergic synapse_Homo sapiens_hsa047270.27167153

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